Hub : Genes

PLA2G15

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0440 0.0210 0.00160 0.032 0.019 0.019 0.020 0.028 8.6e-05 0.0018 0.00190 0.0017 0.00019
2 GTEx Artery Aorta 0.1060 0.0450 0.00050 0.033 NA 0.047 NA 0.068 6.5e-03 NA 0.00130 NA 0.00014
3 GTEx Skin Sun Exposed Lower leg 0.0740 0.0280 0.00001 0.026 NA 0.036 NA 0.034 3.1e-03 NA 0.00060 NA 0.00076
4 GTEx Thyroid 0.0550 0.0250 0.00210 0.037 NA 0.039 NA 0.036 7.2e-04 NA 0.00057 NA 0.00094
5 METSIM Adipose 0.0318 0.0201 0.00760 0.014 0.012 0.001 0.011 0.011 2.7e-03 0.0048 0.19000 0.0068 0.00760

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.9 3.1 6.6 -1.7 0.8 1.4 1.9 2.6
Bipolar Disorder or Schizophrenia 0.6 1.5 3.0 -1.3 -1.7 1.7 0.5 0.0
Depressed Affect (Nagel 2018) 2.7 5.7 11.7 1.4 -3.2 -0.4 -2.0 -3.4
Depression (Nagel 2018) 4.1 6.1 13.4 1.5 -3.1 -0.3 -2.3 -3.7
Intelligence (Savage-Jansen 2018) 4.6 14.2 29.3 -1.8 5.2 0.2 3.3 5.4
Neuroticism (Nagel 2018) 4.2 9.8 17.8 2.2 -4.1 -1.0 -2.9 -4.2
Schizophrenia (2018) 1.3 2.8 8.1 -0.3 -2.8 1.0 -0.8 -2.0
Schizophrenia vs Biploar Disorder 3.0 4.0 6.7 -1.3 -2.6 2.2 0.3 -2.5
Worry (Nagel 2018) 3.5 7.5 11.1 2.3 -3.3 -1.3 -2.8 -3.3
Alzheimer’s Disease (in mother) 0.5 0.6 1.7 -0.4 -1.0 0.4 0.0 -1.3
Alzheimer’s Disease (in father) 0.4 0.4 0.7 0.8 -0.0 -0.7 -0.8 -0.4
Alzheimer’s Disease (including proxy) 0.5 0.7 1.7 0.4 -0.9 -0.5 -0.6 -1.3
Crohns Disease (2017) 1.4 3.0 6.7 -0.4 2.6 -0.8 1.6 2.2
Irritable Bowel Disease (IBD) 0.3 0.7 2.2 0.7 1.0 -1.5 0.0 0.3
Ulcerative Colitis (UC) 0.5 0.9 1.8 0.8 -0.9 -0.8 -0.9 -1.3
Major Depression (MDD) 1.4 1.7 3.1 -1.5 0.6 1.1 1.8 1.2
Reaction Time 0.3 0.6 1.0 -1.0 0.2 0.8 0.9 0.6
Verbal and Numeric Reasoning (VNR) 2.6 6.2 11.9 -1.5 3.3 0.3 2.5 3.4
Breast Cancer 0.5 1.2 2.9 1.2 1.2 -1.7 -0.6 0.2
Ovarian Cancer 3.0 3.9 6.8 2.5 1.5 -2.6 -2.1 0.3
Prostate Cancer 1.6 2.2 3.5 1.9 -1.2 -1.3 -1.8 -1.1
Age at First Birth 4.6 6.7 15.2 -1.4 3.3 0.1 2.4 3.9
Bipolar Disorder (2011) 4.5 4.3 10.0 -1.8 1.4 1.2 2.2 3.2
Body Mass Index (BMI) (2010) 3.3 4.6 7.7 -2.6 1.3 1.8 2.8 1.9
Coronary Artery Disease (CAD) 0.2 0.3 0.8 0.3 0.9 -0.4 -0.0 0.6
Crohns Disease (2012) 1.9 3.1 5.5 -1.6 1.8 0.8 1.9 2.3
Mean Putamen Volume 1.1 1.2 3.0 1.4 0.4 -1.7 -1.1 -0.0
Fasting Glucose 2.6 3.1 7.3 0.9 2.7 -1.9 0.2 1.8
HbA1C 3.6 4.0 5.3 -2.3 1.8 1.5 2.0 2.2
HDL Cholesterol 20.5 34.1 84.5 -2.4 -9.2 5.2 -0.3 -7.3
LDL Cholesterol 0.8 1.2 1.9 1.4 -0.7 -1.2 -1.4 -0.7
Lupus 1.5 2.3 7.5 0.1 -2.7 1.0 -0.6 -1.6
Neuroticism (2016) 3.3 4.7 9.3 1.6 -3.0 -0.6 -2.0 -2.7
Primary Biliary Cirrhosis 4.3 6.1 15.2 -1.3 -3.9 2.8 -0.2 -2.4
Rheumatoid Arthritis 0.9 1.2 3.1 1.3 0.2 -1.8 -1.1 -0.0
Schizophrenia (2014) 1.8 4.0 9.7 -1.1 -3.1 2.2 -0.3 -2.0
Triglycerides 0.7 1.2 3.0 0.3 1.7 -0.4 0.1 1.7
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.1 0.1 1.1 -0.2 0.4 1.4
Ulcerative Colitis 1.3 1.9 2.5 1.6 -0.4 -1.5 -1.5 -1.5
Blood Eosinophil Count 5.6 42.9 78.7 4.9 -7.3 -2.7 -7.1 -8.9
Blood Platelet Count 0.3 3.3 7.9 -2.2 -1.0 2.8 1.5 0.6
Blood Red Count 2.9 28.0 57.2 -5.8 -5.5 7.6 3.8 -2.4
Blood White Count 0.4 2.6 5.6 0.5 -2.4 -0.5 -1.2 -2.4
Heel T-Score 0.2 1.5 5.4 -0.2 1.1 -0.1 0.9 2.3
BMI 2.5 14.4 23.4 -4.0 2.1 3.6 4.8 3.8
Height 0.6 11.2 20.2 -4.2 -0.9 4.5 4.2 -0.1
Waist Hip Ratio (WHR) 1.0 4.4 6.7 1.9 -1.9 -1.7 -2.2 -2.6
Systolic Blood Pressure 0.6 2.9 5.8 -0.9 2.4 -0.2 1.9 2.1
Smoking Status 0.3 0.8 2.2 -0.2 -1.0 0.7 -0.3 -1.5
Allergy or Eczema 1.6 4.2 6.8 1.6 2.6 -2.4 -1.2 2.2
Cardiovascular Disease 0.2 0.5 1.5 -0.6 -0.1 0.7 1.2 -0.4
Hypothyroidism (self reported) 0.5 1.2 4.1 -0.5 -2.0 1.0 0.1 -0.8
Respiratory disease 1.9 4.1 7.8 1.3 2.3 -2.3 -0.9 2.8
Type 2 Diabetes (T2D) (2018) 0.6 1.1 4.2 0.6 -1.0 -0.2 -0.5 -2.0
Lung FEV1/FVC ratio 1.8 9.1 18.7 -2.6 -3.5 4.3 1.6 -2.1
Lung FVC 1.8 9.2 21.4 -1.4 4.6 -0.3 2.2 4.2
Neuroticism 3.6 8.8 14.2 2.3 -3.8 -1.0 -3.1 -3.7
Chronotype (morning person) 1.6 3.7 7.7 -1.3 2.4 0.8 1.7 2.8
Hair Pigment 0.1 2.3 4.4 -2.0 -0.7 2.1 1.6 -0.1
Tanning 0.1 0.8 2.7 -0.7 -0.5 1.6 0.1 -0.6
Hand grip strength (left) 0.0 0.1 0.2 -0.5 -0.1 -0.1 0.5 -0.2
Number of treatments/medications taken 1.5 2.7 6.2 0.6 -2.3 0.6 -1.0 -2.5
Average weekly spirits intake 0.7 0.9 2.5 1.1 0.6 -1.6 -0.7 0.1
Sensitivity / hurt feelings 1.0 1.6 3.7 -0.7 -1.9 1.5 -0.1 -1.3
Frequency of depressed mood in last 2 weeks 1.5 2.0 4.5 0.9 -1.7 -0.1 -1.4 -2.1
Hearing difficulty/problems: Yes 1.3 2.0 3.6 1.8 0.7 -1.9 -1.6 0.6
Relative age of first facial hair 0.3 0.6 0.7 -0.8 0.9 0.8 0.7 0.8
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 0.9 -0.3 0.5 0.4 0.5 1.0
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.1 -0.6 -0.5 1.0 0.3 0.4
Ever had hysterectomy (womb removed) 0.4 0.5 1.0 -0.9 -0.5 1.0 0.6 0.2
Systolic blood pressure, automated reading 1.8 5.1 9.8 -1.5 3.1 0.5 2.4 2.7
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.5 -0.5 0.2 0.7 0.2 -0.5
Angina 0.3 0.4 0.7 0.7 -0.2 -0.8 -0.8 -0.2
Medication for hormone replacement therapy 0.8 0.9 2.0 -1.4 0.5 0.9 1.0 0.7
Vitamin and mineral supplements 1.0 1.3 2.7 -0.8 1.4 0.0 1.6 1.2
Supplements: Zinc 1.1 1.2 1.8 1.1 -1.2 -0.5 -1.3 -1.1
Medication: Co-codamol 0.7 0.8 1.5 -0.5 -1.2 1.0 0.2 -1.2
Medication: Metformin 0.4 0.6 1.3 0.9 -0.5 -0.8 -0.4 -1.1
Diabetes (father) 1.5 1.8 3.6 -1.3 -1.5 1.9 0.8 -1.1
Diabetes (mother) 12.7 16.2 32.5 3.1 -4.4 -1.2 -4.3 -5.7
Severe depression (siblings) 1.7 1.9 2.9 1.0 -1.6 -0.1 -1.7 -1.7
Pack years adult smoking proportion 0.6 0.9 1.4 0.8 -0.9 -0.6 -1.1 -1.2
Impedance of leg (right) 2.8 13.4 21.1 2.6 -4.5 -0.8 -4.2 -4.6
Leg fat-free mass (left) 2.9 15.4 29.9 -4.3 2.4 3.1 5.5 3.6
Trunk fat percentage 1.4 5.4 11.2 -2.0 -2.9 3.3 1.1 -1.5
Hand grip strength (right) 0.2 0.4 1.1 -1.1 -0.0 0.4 0.8 -0.3
Townsend deprivation index at recruitment 0.8 1.1 2.2 1.1 -0.4 -1.3 -1.5 -0.6
Current tobacco smoking 0.5 0.9 1.9 -0.4 -1.3 0.7 0.2 -1.4
Average weekly fortified wine intake 0.6 0.7 1.4 0.3 1.2 -1.1 0.1 0.9
Maternal smoking around birth 0.1 0.2 0.6 -0.4 -0.1 0.5 0.8 0.2
Fed-up feelings 2.4 4.4 9.1 1.6 -2.3 -0.6 -2.1 -3.0
Frequency of unenthusiasm / disinterest in last 2 weeks 6.2 8.3 15.8 2.2 -3.4 -0.6 -3.0 -4.0
Relative age voice broke 1.3 2.0 2.7 -1.3 1.6 1.1 1.5 1.4
Taking other prescription medications 3.2 5.0 6.3 2.5 -2.4 -1.5 -2.3 -2.3
Age when periods started (menarche) 0.3 0.8 1.4 -1.0 0.2 1.0 1.2 0.8
Bilateral oophorectomy (both ovaries removed) 3.1 3.6 9.3 -2.4 -0.7 3.0 1.5 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 3.5 -1.1 1.0 1.1 1.3 1.9
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.9 0.8 -0.7 -0.3 -1.4 -0.6
Qualifications: CSEs or equivalent 0.0 0.0 0.0 -0.0 0.0 -0.0 0.0 -0.0
Serious illness, injury or assault to yourself 0.2 0.2 0.5 -0.7 0.2 0.6 0.5 0.3
High blood pressure 0.1 0.3 0.7 -0.5 0.5 0.4 0.9 -0.4
Hayfever, allergic rhinitis or eczema 1.1 2.4 4.0 1.9 1.4 -2.0 -1.6 0.7
Multivitamins +/- minerals 0.6 0.8 2.1 0.2 -1.4 0.7 -0.9 -0.7
Stomach or abdominal pain in last month 0.7 0.9 2.7 0.1 -1.7 0.7 -0.5 -1.1
Supplements: Glucosamine 1.3 1.7 2.3 -1.3 1.3 0.9 1.4 1.5
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 3.0 1.7 -0.6 -1.2 -1.7 -0.7
Medication: Atenolol 2.2 2.7 5.1 -2.0 0.3 2.1 2.3 -0.0
Medication: Levothyroxine sodium 0.2 0.3 0.5 0.6 -0.7 -0.3 -0.7 -0.0
Sitting height 1.7 12.0 21.3 -4.0 1.1 3.5 4.6 2.9
Chronic bronchitis/emphysema (father) 0.3 0.4 1.0 -0.9 -0.1 1.0 0.3 0.3
High blood pressure (mother) 1.1 1.5 2.4 1.2 -1.6 -0.4 -1.3 -1.3
Body mass index (BMI) 1.6 6.8 11.8 -3.0 1.2 2.7 3.4 2.1
Impedance of leg (left) 3.1 14.9 26.2 2.3 -5.1 -0.2 -4.1 -5.1
Leg predicted mass (left) 2.8 14.8 29.1 -4.2 2.2 3.1 5.4 3.5
Trunk fat mass 1.8 7.9 17.1 -3.3 -1.8 4.1 3.0 -0.1
Waist circumference 1.5 5.5 10.2 -2.9 0.2 2.8 3.2 0.8
Number of incorrect matches in round 1.6 2.7 5.6 1.1 -1.9 -0.2 -1.8 -2.4
Past tobacco smoking 0.2 0.5 0.8 -0.4 0.9 0.0 0.9 0.7
Alcohol usually taken with meals 0.2 0.3 0.8 -0.9 -0.1 0.6 0.5 0.4
Nervous feelings 2.8 5.3 9.0 2.6 -1.6 -1.7 -3.0 -2.2
Frequency of tenseness / restlessness in last 2 weeks 5.3 8.2 16.8 1.5 -4.1 0.2 -2.5 -4.0
Hearing difficulty/problems with background noise 0.5 0.7 1.2 1.1 -0.0 -1.1 -1.0 0.6
Hair/balding pattern: Pattern 2 2.0 2.6 4.9 -1.9 -0.1 1.7 2.2 1.2
Had menopause 0.8 0.9 1.7 0.9 -0.9 -0.5 -1.1 -1.3
Had other major operations 0.2 0.3 0.5 0.1 -0.7 0.1 -0.7 -0.7
Forced vital capacity (FVC) 1.6 6.3 11.8 -1.5 3.3 0.3 2.5 3.4
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 4.8 -0.6 1.2 0.5 1.0 2.2
Ever unenthusiastic/disinterested for a whole week 1.6 1.9 5.6 0.4 -2.4 0.5 -1.1 -1.5
Qualifications: None of the above 2.6 5.6 9.0 2.3 -2.0 -1.5 -3.0 -2.7
Financial difficulties in last 2 years 0.4 0.6 1.3 -0.7 -1.1 0.5 0.4 -0.9
Mouth/teeth dental problems 1.8 2.8 4.8 -2.1 0.7 1.6 2.2 1.2
Heart attack 4.1 5.3 10.6 1.9 -2.4 -0.9 -2.4 -3.3
Allergy 1.3 3.1 5.6 -2.0 -1.2 2.4 1.8 -1.0
Pain all over the body in last month 2.0 2.1 3.2 1.4 -1.3 -1.0 -1.7 -1.8
Diabetes (self-reported) 0.4 0.7 3.0 0.3 -0.6 -0.2 0.0 -1.7
Hayfever/allergic rhinitis (self-reported) 3.2 4.2 7.5 2.4 -1.6 -2.0 -2.7 -1.3
Medication: Ramipril 0.9 1.2 2.5 0.9 -1.1 -0.4 -1.0 -1.6
Medication: Simvastatin 1.4 2.1 4.3 -0.4 -2.0 1.3 -0.0 -2.1
Fluid intelligence score 2.6 5.3 9.9 -1.6 3.1 0.7 2.0 3.1
Illnesses of siblings 0.2 0.2 0.5 0.2 0.6 -0.4 0.1 0.7
Neuroticism score 4.7 9.9 14.1 2.7 -3.6 -1.5 -3.6 -3.8
Weight 2.7 13.5 24.7 -4.4 1.0 4.1 5.0 2.3
Impedance of arm (right) 3.0 13.9 24.3 2.2 -4.9 -0.4 -4.2 -4.8
Arm fat percentage (right) 1.3 4.9 11.0 -2.7 -0.8 3.3 2.3 0.4
Trunk fat-free mass 3.8 21.9 41.9 -5.0 3.3 3.6 6.5 4.3
Hip circumference 1.3 5.4 10.2 -2.8 0.7 2.6 3.2 1.3
Time employed in main current job 0.1 0.2 0.4 0.5 -0.3 -0.6 -0.4 0.1
Alcohol intake versus 10 years previously 1.3 2.0 3.6 -1.9 0.2 1.8 1.5 0.8
Father’s age at death 0.4 0.5 1.5 -0.8 -0.4 1.2 0.6 0.0
Worrier / anxious feelings 1.5 2.8 4.6 1.5 -2.1 -0.7 -2.0 -1.7
Frequency of tiredness / lethargy in last 2 weeks 3.1 5.1 7.3 2.1 -2.3 -1.2 -2.6 -2.7
Falls in the last year 0.8 1.1 2.7 0.6 1.1 -1.0 -0.4 1.6
Hair/balding pattern: Pattern 3 2.5 3.7 10.0 0.6 3.2 -1.4 0.3 2.5
Number of live births 0.8 1.1 3.6 0.2 -1.9 0.4 -0.7 -1.1
Forced expiratory volume in 1-second (FEV1) 1.5 5.1 7.7 -2.2 1.7 1.6 2.8 2.7
Pulse rate 0.3 0.5 1.1 -0.7 -1.1 0.9 0.2 -0.6
Happiness 0.2 0.3 0.5 -0.3 -0.7 0.3 0.4 -0.7
Noisy workplace 1.0 1.2 2.8 0.9 -1.2 -0.2 -1.7 -0.9
Qualifications: A levels/AS levels or equivalent 0.9 2.0 4.9 -0.5 1.7 0.0 1.4 2.2
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.4 0.6 0.5 -0.7 -0.4 0.3
Mouth/teeth dental problems: Dentures 3.8 6.4 10.5 2.9 -1.4 -2.2 -3.2 -2.5
Asthma 1.8 3.6 5.8 1.3 2.4 -2.1 -0.7 2.4
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.5 0.3 -1.2 -0.2 -0.8 -1.2
Medication: Cholesterol lowering 1.8 2.8 6.5 1.1 -2.0 -0.6 -1.4 -2.5
Depression (self-reported) 1.4 1.6 2.5 1.3 -1.3 -0.6 -1.6 -1.4
Medication: Lansoprazole 0.4 0.5 1.2 -0.3 -0.9 0.4 0.3 -1.1
Prospective memory result 1.3 1.6 3.6 -0.3 -1.9 0.9 -0.2 -1.9
Lung cancer (father) 0.2 0.2 0.5 -0.3 -0.6 0.5 0.2 -0.7
Illnesses of mother 2.0 2.5 5.1 -0.9 2.3 -0.1 1.3 2.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.1 8.0 -2.2 2.0 1.3 2.6 2.8
Pulse wave Arterial Stiffness index 2.2 2.6 5.5 -1.0 -2.2 1.2 0.4 -2.4
Impedance of arm (left) 2.8 12.8 21.2 2.4 -4.6 -0.7 -4.2 -4.4
Arm fat mass (right) 2.4 10.0 16.3 -3.9 -0.1 4.0 4.0 1.4
Trunk predicted mass 3.8 21.6 41.3 -5.0 3.3 3.5 6.4 4.3
Standing height 1.0 9.7 17.8 -3.9 -0.3 3.8 4.2 0.9
Length of working week for main job 0.4 0.5 0.9 -0.6 -0.9 0.6 -0.1 -0.9
Exposure to tobacco smoke at home 1.5 1.7 3.0 1.6 -0.9 -1.5 -1.7 -0.2
Breastfed as a baby 0.4 0.5 1.6 0.2 0.9 -0.6 0.2 1.3
Tense / ‘highly strung’ 3.4 5.6 10.2 1.8 -3.1 -0.4 -2.2 -3.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 4.4 0.7 -2.1 0.4 -1.4 -1.7
Hair/balding pattern: Pattern 4 1.7 4.1 8.1 -2.7 0.4 2.1 2.8 -0.2
Birth weight of first child 1.2 2.3 3.7 1.9 -0.7 -1.8 -1.7 -0.9
Peak expiratory flow (PEF) 2.4 5.5 9.5 -2.5 1.3 1.8 3.1 2.6
Pulse wave reflection index 0.2 0.2 0.5 -0.7 0.1 0.3 0.6 -0.5
Ever highly irritable/argumentative for 2 days 5.6 6.8 16.4 0.2 -3.6 1.0 -1.9 -4.0
Loud music exposure frequency 0.5 0.6 0.9 -0.9 0.3 0.8 0.8 0.8
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.5 -0.7 0.3 0.4 0.9 1.2
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.1 -0.8 -1.4 1.5 0.5 -0.5
Blood clot in the leg (DVT) 1.6 2.1 6.5 0.0 -2.6 0.4 -0.9 -1.7
Medication: Paracetamol 0.9 1.5 4.1 -0.0 -1.6 0.4 -0.6 -2.0
Headache pain in last month 0.6 1.1 2.0 -0.9 -1.2 1.4 0.5 0.9
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.0 -0.8 0.1 1.0 0.1 0.8
Glaucoma (self-reported) 0.0 0.0 0.1 -0.1 0.2 -0.1 0.4 0.1
Gout (self-reported) 4.4 6.0 9.7 3.1 -1.1 -2.6 -3.1 -1.7
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.8 -0.1 -1.7 0.6 -0.3 -0.6
Medication: Amlodipine 0.4 0.6 1.3 0.7 1.1 -0.7 -0.1 0.9
Medication: Ventolin 100micrograms inhaler 1.4 1.8 2.9 1.2 1.3 -1.6 -0.6 1.7
Birth weight 2.3 4.9 9.1 3.0 1.4 -2.9 -2.2 0.5
Chronic bronchitis/emphysema (mother) 2.1 2.4 4.4 1.9 -1.4 -1.4 -2.1 -0.9
High blood pressure (siblings) 1.1 1.5 2.8 -1.5 0.3 1.7 1.5 0.5
Forced vital capacity (FVC), Best measure 1.6 5.9 10.9 -1.6 3.2 0.3 2.3 3.3
Body fat percentage 1.1 4.5 10.0 -2.0 -2.4 3.2 1.3 -1.1
Leg fat percentage (right) 0.6 2.3 5.4 -1.5 -1.4 2.3 1.2 -0.6
Arm fat-free mass (right) 3.2 16.6 32.5 -4.4 2.4 3.5 5.7 3.6
Exposure to tobacco smoke outside home 2.4 3.2 4.0 1.9 -2.0 -1.6 -1.8 -1.5
Comparative body size at age 10 4.9 13.5 22.9 -4.8 0.2 4.5 4.8 1.2
Number of full brothers 1.8 2.2 6.7 1.6 1.2 -2.6 -0.7 -0.3
Worry too long after embarrassment 2.2 3.7 6.4 1.8 -2.3 -0.9 -2.5 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.3 0.7 -0.8 -0.1 -1.1 -0.5
Wheeze or whistling in the chest in last year 2.8 5.0 8.4 2.9 -0.5 -2.8 -2.8 -1.1
Number of children fathered 0.3 0.3 1.0 -0.0 0.8 -0.1 0.2 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.8 -0.9 1.3 0.3 1.0 1.2
Age at first live birth 3.2 5.7 10.1 -1.9 2.8 0.8 2.6 3.2
Pulse wave peak to peak time 1.9 2.2 5.6 0.5 2.2 -0.8 0.0 2.4
Health satisfaction 0.5 0.7 1.7 -0.1 -1.3 0.9 -0.4 -0.9
Shortness of breath walking on level ground 0.7 0.8 1.3 0.8 -1.1 -0.6 -1.1 -0.9
Qualifications: College or University degree 3.7 11.5 17.3 -3.2 3.1 2.0 4.2 4.0
Eye problems/disorders: None of the above 1.6 1.8 3.6 0.7 1.8 -1.3 0.1 1.9
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.2 1.0 -0.8 -0.8 -1.1 -0.7
Emphysema/chronic bronchitis 2.0 2.3 4.0 1.9 1.0 -2.0 -1.7 0.3
Medication for pain relief, constipation, heartburn 1.8 3.1 7.4 -0.5 2.4 -0.1 1.4 2.7
Neck or shoulder pain in last month 1.1 1.5 4.3 -0.5 -2.1 1.4 -0.0 -1.1
Medication: Blood pressure 0.7 1.2 3.8 -0.1 1.9 -0.6 1.1 0.9
Angina (self-reported) 0.3 0.4 0.7 0.8 -0.1 -0.9 -0.8 -0.1
Migraine (self-reported) 5.2 6.4 10.7 -3.2 1.2 2.8 3.3 1.5
Medication: Ibuprofen 0.6 0.7 1.2 0.5 -1.0 -0.3 -1.0 -1.1
Medication: Allopurinol 2.7 3.6 6.0 2.4 -0.8 -2.2 -2.4 -0.9
Medication: Omeprazole 1.5 1.7 4.0 -0.3 -2.0 1.2 0.1 -1.8
Medication: Seretide 50 evohaler 3.6 4.2 8.8 1.6 2.6 -3.0 -0.4 1.6
Mean time to correctly identify matches 0.0 0.1 0.3 -0.2 -0.1 0.2 0.2 0.5
Heart disease (mother) 0.6 0.7 1.6 -0.7 -0.9 1.3 0.2 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.9 1.4 0.1 -1.2 -0.8 -0.4
Whole body fat mass 1.8 7.7 16.0 -3.3 -1.5 4.0 3.1 0.2
Leg fat mass (right) 2.0 7.7 13.7 -3.4 -0.5 3.7 3.5 0.9
Arm predicted mass (right) 3.6 18.4 36.1 -4.7 2.4 3.8 6.0 3.7
Pulse rate, automated reading 0.2 0.7 1.2 0.1 -1.1 0.0 -1.0 -1.1
Alcohol intake frequency. 0.4 0.8 2.0 0.1 -1.4 0.3 -0.5 -1.4
Comparative height size at age 10 1.1 5.8 10.4 -2.7 -1.8 3.2 2.4 -1.5
Number of full sisters 0.4 0.5 0.9 0.6 -0.9 -0.5 -0.8 -0.8
Suffer from ‘nerves’ 4.4 6.9 9.6 2.7 -2.9 -1.4 -3.1 -2.7
Overall health rating 1.9 4.0 8.7 1.3 -3.0 -0.1 -1.7 -2.6
Chest pain or discomfort 4.9 7.1 12.3 3.2 -0.8 -3.0 -3.5 -1.8
Had major operations 0.8 1.0 2.6 0.6 1.1 -0.8 0.0 1.6
Age at last live birth 1.1 1.6 2.7 -1.6 0.3 1.6 1.5 0.7
Family relationship satisfaction 1.0 1.2 2.7 -1.4 -0.9 1.6 0.8 -0.0
Leg pain on walking 0.3 0.3 0.7 0.3 -0.8 -0.2 -0.5 -0.8
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 3.5 -1.6 1.0 0.7 1.9 1.3
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.2 -0.5 1.1 0.2 0.4 0.8
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 4.5 0.0 2.1 -0.6 0.5 2.1
Medication: Aspirin 1.8 2.4 7.0 0.2 -1.9 0.3 -1.1 -2.7
Supplements: Vitamin C 0.4 0.5 1.3 0.5 -0.5 -0.3 -0.9 -1.1
Knee pain experienced in last month 1.6 2.4 5.7 1.0 -1.7 -0.3 -1.5 -2.4
Hypertension (Self-reported) 0.2 0.5 1.4 -0.5 0.8 0.4 1.2 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.1 -0.1 0.3 0.2 0.2 -0.1
Illnesses of father: Heart disease 0.1 0.2 0.7 -0.1 0.1 0.9 0.1 0.3
Illnesses of siblings: Diabetes 1.9 2.4 4.5 2.1 -0.5 -1.7 -2.0 -0.7
Smoking status: Previous 0.2 0.3 1.0 0.7 0.0 -0.3 -1.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 1.8 -1.0 0.1 1.0 1.4 0.8
Whole body fat-free mass 3.4 19.4 37.9 -4.8 2.8 3.5 6.2 4.0
Leg fat-free mass (right) 2.7 14.6 28.5 -4.2 2.4 3.0 5.3 3.4
Arm fat percentage (left) 1.2 4.9 11.0 -2.7 -0.8 3.3 2.3 0.4
Average weekly red wine intake 2.3 3.3 8.3 2.1 0.9 -2.9 -1.7 0.7
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.7 0.7 0.3 -0.4 -0.8 0.0
Mood swings 2.0 3.6 8.1 0.2 -2.8 0.8 -1.1 -2.8
Loneliness, isolation 4.3 5.9 10.5 1.9 -2.9 -1.0 -2.4 -3.2
Long-standing illness, disability or infirmity 0.6 0.9 1.6 1.3 -0.7 -1.1 -0.8 -0.6
Ever had bowel cancer screening 0.2 0.3 0.5 0.5 0.7 -0.6 -0.2 0.4
Diabetes diagnosed by doctor 1.2 2.0 7.1 0.7 -1.5 -0.3 -0.6 -2.7
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 -0.3 -0.8 0.4 0.0 -0.5
Friendships satisfaction 0.1 0.2 0.4 -0.6 -0.1 0.3 0.6 -0.3
Qualifications: nursing, teaching 0.2 0.3 0.5 -0.4 -0.2 0.5 0.7 0.6
Commuting to job workplace: Walk 0.4 0.4 0.8 -0.7 0.5 0.4 0.6 0.9
Eye problems/disorders: Cataract 0.9 1.0 1.6 -0.9 -1.3 1.2 0.3 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 1.2 -1.0 0.7 1.1 1.0 1.0
Medication for cholesterol 1.4 2.1 3.8 1.9 0.6 -1.9 -1.5 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 3.3 1.4 -1.1 -0.7 -1.8 -1.0
Back pain experienced in last month 1.1 1.7 4.7 -0.4 -2.2 0.9 -0.2 -1.6
Mineral and other dietary supplements 0.9 1.2 2.0 0.8 -1.4 -0.7 -0.9 -1.3
Breast cancer (self-reported) 0.4 0.5 0.7 0.8 -0.4 -0.8 -0.8 -0.7
Asthma (self-reported) 2.0 3.9 6.8 1.2 2.6 -2.1 -0.6 2.5
Osteoporosis (self-reported) 0.9 1.1 2.2 1.3 0.5 -1.5 -1.2 -0.0
Osteoarthritis (self-reported) 0.7 1.0 1.7 -1.1 -0.6 1.3 0.9 -0.9
Medication: Aspirin 2.0 2.7 6.9 0.3 -2.1 0.5 -1.2 -2.6
Medication: Gliclazide 1.2 1.3 2.0 1.4 -0.3 -1.2 -1.1 -1.4
Illnesses of father: None of the above (group 1) 0.3 0.4 0.8 -0.1 0.8 -0.9 0.6 0.3
Smoking status: Current 0.4 0.7 1.7 -0.4 -1.3 0.5 0.1 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 2.5 -1.6 0.6 1.5 1.4 1.5
Whole body water mass 3.5 20.2 38.9 -4.9 2.9 3.6 6.2 4.1
Leg predicted mass (right) 2.7 14.5 28.5 -4.2 2.4 3.0 5.3 3.4
Arm fat mass (left) 2.6 10.7 18.1 -4.1 -0.0 4.3 4.1 1.5
Number of self-reported non-cancer illnesses 0.8 1.5 2.7 1.6 -1.0 -0.7 -1.4 -1.1
Average weekly champagne plus white wine intake 2.2 3.0 7.1 -1.7 -1.8 2.7 0.8 -1.0
Miserableness 1.9 3.3 5.6 1.5 -2.2 -0.5 -1.9 -2.4
Guilty feelings 2.7 4.0 6.5 2.2 -1.2 -1.9 -2.5 -1.8
Wears glasses or contact lenses 0.7 0.9 1.8 -1.1 -0.4 1.3 1.1 0.2
Ever taken oral contraceptive pill 1.0 1.2 2.3 1.5 0.1 -1.1 -1.3 0.8
Hearing aid user 0.4 0.4 1.0 0.2 1.0 -0.7 0.1 0.9
Mother’s age at death 0.8 1.0 1.9 -1.1 -0.9 1.4 0.6 -0.8
Financial situation satisfaction 0.4 0.5 1.1 0.2 -1.1 0.4 -0.7 -0.7
Tinnitus: Yes, now most or all of the time 0.3 0.4 0.7 0.6 -0.1 -0.8 -0.3 0.8
Commuting to job workplace: Public transport 0.4 0.5 0.9 -0.6 0.7 1.0 0.6 0.6
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 -0.3 -0.2 0.5 0.4 -0.4
Medication: Blood pressure 0.8 1.6 3.3 -1.4 -0.7 1.8 1.3 -0.6
Pain type(s) experienced in last month: Hip pain 1.1 1.3 2.9 0.9 -1.7 -0.1 -1.2 -1.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.8 0.9 0.7 -0.5 -0.9 0.3
High cholesterol (Self-reported) 1.6 2.9 7.6 0.5 -2.3 0.4 -1.0 -2.8
Medication: Bendroflumethiazide 1.4 2.2 4.0 -1.6 0.9 1.7 2.0 0.6
Medication: Paracetamol 0.7 1.0 2.3 0.5 -1.2 0.1 -1.0 -1.5
Medication: Lisinopril 0.6 0.7 2.5 -0.3 1.6 -0.4 1.0 0.1
Medication: Atorvastatin 0.9 1.1 2.4 0.7 -1.1 -0.6 -1.0 -1.6
Illnesses of father: High blood pressure 0.2 0.3 0.9 -0.4 -0.5 0.9 0.2 0.2
Alcohol drinker status: Never 1.6 1.9 3.3 1.8 -0.3 -1.8 -1.6 -0.8
Ever smoked 0.6 1.0 2.8 -0.2 -1.7 0.9 -0.6 -1.2
Basal metabolic rate 3.5 19.2 37.3 -4.9 2.5 3.8 6.1 3.7
Leg fat percentage (left) 1.0 3.4 8.1 -1.9 -1.6 2.9 1.5 -0.7
Arm fat-free mass (left) 3.8 19.4 37.5 -4.9 2.5 4.0 6.1 3.6
Number of operations (self-reported) 0.9 1.3 2.4 -1.4 -0.3 1.6 1.0 1.1
Average weekly beer plus cider intake 0.9 1.3 2.6 1.6 -0.3 -1.3 -1.4 -0.3
Irritability 2.0 3.4 7.1 -0.0 -2.6 1.2 -1.2 -2.7
Risk taking 0.6 0.9 1.7 -1.3 0.2 1.0 0.8 0.9
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.4 1.2 -0.0 -0.9 -1.2 -0.1
Fractured/broken bones in last 5 years 0.4 0.5 1.1 -1.1 0.3 0.7 0.7 0.4
Age started oral contraceptive pill 0.8 1.0 2.6 -0.1 1.3 -0.6 0.7 1.6
Diastolic blood pressure, automated reading 2.0 6.3 10.0 -2.8 1.5 2.6 3.2 2.0
Ever depressed for a whole week 1.0 1.3 3.5 -0.4 -1.9 1.1 -0.0 -1.2
Unable to work because of sickness or disability 0.5 0.7 1.4 1.0 -0.0 -1.2 -0.9 -0.4
Commuting to job workplace: Cycle 0.1 0.2 0.3 0.5 0.4 -0.6 -0.2 -0.4
Myopia 1.1 1.6 3.0 -0.9 1.4 0.8 1.2 1.7
Vascular/heart problems diagnosed by doctor 0.1 0.3 1.2 -0.0 0.4 -0.2 -0.2 1.1
Cholesterol lowering medication 1.2 1.8 4.5 -0.4 -1.8 1.0 -0.2 -2.1
Medication: Omeprazole (e.g. Zanprol) 1.5 1.9 3.2 -1.0 -1.8 1.7 0.6 -1.4
Pain experienced in last month 1.1 1.9 6.2 0.3 2.5 -1.0 0.4 1.4
Supplements: Calcium 1.2 1.3 2.5 1.6 -0.2 -1.6 -1.2 -0.4
Basal cell carcinoma (self-reported) 1.1 1.3 2.7 0.4 1.5 -1.2 0.5 1.6
Heart attack/myocardial infarction (self-reported) 5.0 6.5 13.7 2.0 -2.9 -0.7 -2.5 -3.7
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 7.7 0.2 -2.8 0.3 -1.1 -2.1
Heart disease (siblings) 1.8 2.3 4.3 1.0 -2.1 -0.4 -1.7 -1.7
Alcohol drinker status: Previous 2.3 2.6 6.2 0.0 -2.1 1.0 -1.2 -2.5
Pack years of smoking 0.4 0.5 1.0 0.5 -0.8 -0.4 -0.8 -1.0
Impedance of whole body 3.9 19.8 31.2 3.2 -5.5 -1.0 -5.2 -5.6
Leg fat mass (left) 2.2 8.7 15.9 -3.6 -0.6 4.0 3.7 0.9
Arm predicted mass (left) 3.9 19.6 38.1 -5.0 2.5 4.0 6.2 3.6