[Hub]/) : Traits : Intelligence (Savage-Jansen 2018) :

chr17:55,681,549-57,989,860

Best TWAS P=8.85e-14 · Best GWAS P=1.87e-13 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TEX14 0.11 0.06 bslmm 368 0.09 2.3e-11 -6.9 6.3 3.2e-10 -0.78 0.10 0.90 FALSE
2 GTEx Adipose Subcutaneous TRIM37 0.18 0.22 enet 25 0.24 6.9e-20 -7.1 7.1 1.5e-12 -0.95 0.03 0.97 FALSE
3 GTEx Adipose Subcutaneous SMG8 0.04 0.05 lasso 2 0.04 2.4e-04 -4.8 5.8 5.4e-09 -0.79 0.05 0.83 FALSE
4 GTEx Adipose Subcutaneous SKA2 0.06 0.03 lasso 6 0.03 1.3e-03 -7.3 -6.0 2.5e-09 0.92 0.04 0.95 FALSE
5 GTEx Adipose Subcutaneous AC099850.1 0.04 0.06 lasso 1 0.05 5.2e-05 -7.1 7.1 1.0e-12 -1.00 0.04 0.95 FALSE
6 GTEx Adipose Visceral Omentum TRIM37 0.19 0.25 lasso 5 0.25 3.1e-13 -6.9 6.9 3.9e-12 -0.98 0.05 0.95 FALSE
7 GTEx Artery Aorta TRIM37 0.06 0.03 enet 9 0.04 2.4e-03 -7.0 6.6 5.5e-11 -0.87 0.06 0.92 FALSE
8 GTEx Artery Tibial BZRAP1 0.10 0.08 lasso 3 0.06 1.2e-05 -5.6 5.6 1.8e-08 -0.77 0.12 0.84 FALSE
9 GTEx Artery Tibial SKA2 0.07 0.07 lasso 5 0.08 1.4e-06 2.8 -5.4 5.7e-08 0.75 0.14 0.85 FALSE
10 GTEx Brain Putamen basal ganglia SUPT4H1 0.30 0.30 lasso 7 0.26 6.5e-07 5.1 -5.7 1.2e-08 0.37 0.25 0.40 FALSE
11 GTEx Breast Mammary Tissue TRIM37 0.26 0.17 enet 33 0.17 3.7e-09 -7.2 6.3 3.6e-10 -0.87 0.05 0.95 FALSE
12 GTEx Breast Mammary Tissue (Female) TRIM37 0.18 0.08 lasso 1 0.02 8.2e-02 -7.2 7.2 6.3e-13 -0.96 0.05 0.79 FALSE
13 GTEx Cells EBV-transformed lymphocytes RAD51C 0.21 0.10 lasso 6 0.17 2.8e-06 3.7 6.1 8.4e-10 -0.65 0.27 0.70 FALSE
14 GTEx Cells Transformed fibroblasts RP11-112H10.4 0.04 0.02 lasso 2 0.02 1.9e-02 -7.4 7.3 3.8e-13 -1.00 0.03 0.92 FALSE
15 GTEx Colon Transverse TRIM37 0.14 0.15 lasso 6 0.17 1.5e-08 -7.0 6.8 9.9e-12 -0.89 0.05 0.95 FALSE
16 GTEx Esophagus Gastroesophageal Junction TRIM37 0.15 0.06 lasso 5 0.10 2.4e-04 -6.7 6.0 1.6e-09 -0.83 0.10 0.86 FALSE
17 GTEx Esophagus Muscularis TRIM37 0.11 0.05 lasso 5 0.09 2.7e-06 -7.0 6.3 2.7e-10 -0.86 0.05 0.95 FALSE
18 GTEx Esophagus Muscularis AC099850.1 0.06 0.00 enet 22 0.00 1.7e-01 -7.2 7.1 1.2e-12 -0.89 0.04 0.82 FALSE
19 GTEx Liver BZRAP1 0.16 0.01 lasso 1 0.00 2.6e-01 -5.6 5.6 2.1e-08 -0.80 0.04 0.63 FALSE
20 GTEx Lung TRIM37 0.05 0.04 enet 7 0.05 5.3e-05 -7.2 6.6 4.4e-11 -0.96 0.05 0.95 FALSE
21 GTEx Muscle Skeletal TRIM37 0.14 0.09 enet 23 0.15 6.7e-15 -7.3 5.7 1.6e-08 -0.83 0.05 0.95 FALSE
22 GTEx Muscle Skeletal SMG8 0.05 0.02 enet 7 0.02 5.9e-03 -4.8 6.3 2.6e-10 -0.82 0.04 0.94 FALSE
23 GTEx Nerve Tibial BZRAP1 0.11 0.08 enet 7 0.09 3.6e-07 -4.1 5.2 1.9e-07 -0.77 0.15 0.85 FALSE
24 GTEx Nerve Tibial TRIM37 0.18 0.16 lasso 11 0.23 4.3e-16 4.1 6.3 3.6e-10 -0.88 0.07 0.93 FALSE
25 GTEx Nerve Tibial SMG8 0.08 0.06 lasso 7 0.05 1.0e-04 -7.2 7.0 2.2e-12 -0.99 0.05 0.93 FALSE
26 GTEx Pancreas TRIM37 0.08 0.05 lasso 7 0.02 3.2e-02 -7.3 7.5 8.9e-14 -0.96 0.05 0.84 TRUE
27 GTEx Skin Sun Exposed Lower leg BZRAP1 0.09 0.04 enet 10 0.05 1.2e-04 -4.1 5.8 5.0e-09 -0.67 0.53 0.32 FALSE
28 GTEx Spleen TRIM37 0.13 0.08 enet 16 0.18 2.8e-05 -7.2 6.8 9.7e-12 -0.87 0.04 0.87 FALSE
29 GTEx Stomach TRIM37 0.13 0.08 enet 16 0.09 4.5e-05 -7.3 5.9 4.4e-09 -0.84 0.05 0.93 FALSE
30 GTEx Testis TRIM37 0.17 0.23 lasso 6 0.19 6.3e-09 -6.7 -6.7 1.6e-11 0.91 0.09 0.91 FALSE
31 GTEx Thyroid RAD51C 0.12 0.11 lasso 5 0.08 6.8e-07 3.6 5.4 5.1e-08 -0.60 0.96 0.04 FALSE
32 GTEx Thyroid TRIM37 0.04 0.04 enet 7 0.06 2.4e-05 -7.2 6.4 1.8e-10 -0.82 0.08 0.89 FALSE
33 GTEx Thyroid SKA2 0.05 0.00 enet 11 0.02 2.2e-02 1.3 -5.2 2.2e-07 0.72 0.07 0.62 FALSE
34 GTEx Whole Blood TRIM37 0.12 0.18 enet 21 0.18 1.8e-16 -7.0 7.2 8.5e-13 -0.97 0.05 0.95 FALSE
35 GTEx Whole Blood AC099850.1 0.04 0.04 lasso 3 0.05 3.2e-05 -7.1 6.1 1.4e-09 -0.89 0.04 0.94 FALSE
36 METSIM Adipose TRIM37 0.11 0.11 bslmm 328 0.12 2.0e-17 -7.4 6.8 7.8e-12 -0.95 0.04 0.96 FALSE
37 NTR Blood TRIM37 0.02 0.03 lasso 4 0.03 6.4e-11 -7.4 7.3 2.3e-13 -0.97 0.04 0.96 FALSE
38 The Cancer Genome Atlas Bladder Urothelial Carcinoma SKA2 0.04 0.01 blup 42 0.02 1.7e-02 3.0 -5.5 4.1e-08 0.83 0.02 0.61 FALSE
39 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TRIM37 0.12 0.05 blup 62 0.09 1.3e-10 -7.3 6.2 4.7e-10 -0.89 0.02 0.98 FALSE
40 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma PPM1E 0.12 0.02 blup 88 0.07 7.0e-04 -6.9 -6.2 4.7e-10 0.77 0.03 0.65 FALSE
41 The Cancer Genome Atlas Prostate Adenocarcinoma TEX14 0.04 0.02 blup 77 0.04 4.1e-05 -7.2 6.1 1.0e-09 -0.86 0.02 0.98 FALSE
42 The Cancer Genome Atlas Prostate Adenocarcinoma TRIM37 0.05 0.03 blup 62 0.05 3.1e-06 -7.2 6.3 3.1e-10 -0.91 0.02 0.98 FALSE
43 The Cancer Genome Atlas Soft Tissue Sarcoma MTMR4 0.07 0.00 blup 40 0.03 6.6e-03 6.4 -7.3 4.2e-13 0.82 0.01 0.61 FALSE
44 The Cancer Genome Atlas Thyroid Carcinoma RAD51C 0.10 0.08 lasso 5 0.10 7.7e-10 3.3 5.4 6.3e-08 -0.62 0.38 0.61 FALSE
45 The Cancer Genome Atlas Thyroid Carcinoma TRIM37 0.05 0.03 blup 62 0.05 2.7e-05 -7.0 6.2 7.5e-10 -0.87 0.02 0.95 FALSE