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chr17:55,681,549-57,989,860

Best TWAS P=8.85e-14 · Best GWAS P=1.87e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TEX14	0.11	0.06	bslmm	368	0.09	2.3e-11	-6.9	6.3	3.2e-10	-0.78	0.10	0.90	FALSE
2	GTEx	Adipose Subcutaneous	TRIM37	0.18	0.22	enet	25	0.24	6.9e-20	-7.1	7.1	1.5e-12	-0.95	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	SMG8	0.04	0.05	lasso	2	0.04	2.4e-04	-4.8	5.8	5.4e-09	-0.79	0.05	0.83	FALSE
4	GTEx	Adipose Subcutaneous	SKA2	0.06	0.03	lasso	6	0.03	1.3e-03	-7.3	-6.0	2.5e-09	0.92	0.04	0.95	FALSE
5	GTEx	Adipose Subcutaneous	AC099850.1	0.04	0.06	lasso	1	0.05	5.2e-05	-7.1	7.1	1.0e-12	-1.00	0.04	0.95	FALSE
6	GTEx	Adipose Visceral Omentum	TRIM37	0.19	0.25	lasso	5	0.25	3.1e-13	-6.9	6.9	3.9e-12	-0.98	0.05	0.95	FALSE
7	GTEx	Artery Aorta	TRIM37	0.06	0.03	enet	9	0.04	2.4e-03	-7.0	6.6	5.5e-11	-0.87	0.06	0.92	FALSE
8	GTEx	Artery Tibial	BZRAP1	0.10	0.08	lasso	3	0.06	1.2e-05	-5.6	5.6	1.8e-08	-0.77	0.12	0.84	FALSE
9	GTEx	Artery Tibial	SKA2	0.07	0.07	lasso	5	0.08	1.4e-06	2.8	-5.4	5.7e-08	0.75	0.14	0.85	FALSE
10	GTEx	Brain Putamen basal ganglia	SUPT4H1	0.30	0.30	lasso	7	0.26	6.5e-07	5.1	-5.7	1.2e-08	0.37	0.25	0.40	FALSE
11	GTEx	Breast Mammary Tissue	TRIM37	0.26	0.17	enet	33	0.17	3.7e-09	-7.2	6.3	3.6e-10	-0.87	0.05	0.95	FALSE
12	GTEx	Breast Mammary Tissue (Female)	TRIM37	0.18	0.08	lasso	1	0.02	8.2e-02	-7.2	7.2	6.3e-13	-0.96	0.05	0.79	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	RAD51C	0.21	0.10	lasso	6	0.17	2.8e-06	3.7	6.1	8.4e-10	-0.65	0.27	0.70	FALSE
14	GTEx	Cells Transformed fibroblasts	RP11-112H10.4	0.04	0.02	lasso	2	0.02	1.9e-02	-7.4	7.3	3.8e-13	-1.00	0.03	0.92	FALSE
15	GTEx	Colon Transverse	TRIM37	0.14	0.15	lasso	6	0.17	1.5e-08	-7.0	6.8	9.9e-12	-0.89	0.05	0.95	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	TRIM37	0.15	0.06	lasso	5	0.10	2.4e-04	-6.7	6.0	1.6e-09	-0.83	0.10	0.86	FALSE
17	GTEx	Esophagus Muscularis	TRIM37	0.11	0.05	lasso	5	0.09	2.7e-06	-7.0	6.3	2.7e-10	-0.86	0.05	0.95	FALSE
18	GTEx	Esophagus Muscularis	AC099850.1	0.06	0.00	enet	22	0.00	1.7e-01	-7.2	7.1	1.2e-12	-0.89	0.04	0.82	FALSE
19	GTEx	Liver	BZRAP1	0.16	0.01	lasso	1	0.00	2.6e-01	-5.6	5.6	2.1e-08	-0.80	0.04	0.63	FALSE
20	GTEx	Lung	TRIM37	0.05	0.04	enet	7	0.05	5.3e-05	-7.2	6.6	4.4e-11	-0.96	0.05	0.95	FALSE
21	GTEx	Muscle Skeletal	TRIM37	0.14	0.09	enet	23	0.15	6.7e-15	-7.3	5.7	1.6e-08	-0.83	0.05	0.95	FALSE
22	GTEx	Muscle Skeletal	SMG8	0.05	0.02	enet	7	0.02	5.9e-03	-4.8	6.3	2.6e-10	-0.82	0.04	0.94	FALSE
23	GTEx	Nerve Tibial	BZRAP1	0.11	0.08	enet	7	0.09	3.6e-07	-4.1	5.2	1.9e-07	-0.77	0.15	0.85	FALSE
24	GTEx	Nerve Tibial	TRIM37	0.18	0.16	lasso	11	0.23	4.3e-16	4.1	6.3	3.6e-10	-0.88	0.07	0.93	FALSE
25	GTEx	Nerve Tibial	SMG8	0.08	0.06	lasso	7	0.05	1.0e-04	-7.2	7.0	2.2e-12	-0.99	0.05	0.93	FALSE
26	GTEx	Pancreas	TRIM37	0.08	0.05	lasso	7	0.02	3.2e-02	-7.3	7.5	8.9e-14	-0.96	0.05	0.84	TRUE
27	GTEx	Skin Sun Exposed Lower leg	BZRAP1	0.09	0.04	enet	10	0.05	1.2e-04	-4.1	5.8	5.0e-09	-0.67	0.53	0.32	FALSE
28	GTEx	Spleen	TRIM37	0.13	0.08	enet	16	0.18	2.8e-05	-7.2	6.8	9.7e-12	-0.87	0.04	0.87	FALSE
29	GTEx	Stomach	TRIM37	0.13	0.08	enet	16	0.09	4.5e-05	-7.3	5.9	4.4e-09	-0.84	0.05	0.93	FALSE
30	GTEx	Testis	TRIM37	0.17	0.23	lasso	6	0.19	6.3e-09	-6.7	-6.7	1.6e-11	0.91	0.09	0.91	FALSE
31	GTEx	Thyroid	RAD51C	0.12	0.11	lasso	5	0.08	6.8e-07	3.6	5.4	5.1e-08	-0.60	0.96	0.04	FALSE
32	GTEx	Thyroid	TRIM37	0.04	0.04	enet	7	0.06	2.4e-05	-7.2	6.4	1.8e-10	-0.82	0.08	0.89	FALSE
33	GTEx	Thyroid	SKA2	0.05	0.00	enet	11	0.02	2.2e-02	1.3	-5.2	2.2e-07	0.72	0.07	0.62	FALSE
34	GTEx	Whole Blood	TRIM37	0.12	0.18	enet	21	0.18	1.8e-16	-7.0	7.2	8.5e-13	-0.97	0.05	0.95	FALSE
35	GTEx	Whole Blood	AC099850.1	0.04	0.04	lasso	3	0.05	3.2e-05	-7.1	6.1	1.4e-09	-0.89	0.04	0.94	FALSE
36	METSIM	Adipose	TRIM37	0.11	0.11	bslmm	328	0.12	2.0e-17	-7.4	6.8	7.8e-12	-0.95	0.04	0.96	FALSE
37	NTR	Blood	TRIM37	0.02	0.03	lasso	4	0.03	6.4e-11	-7.4	7.3	2.3e-13	-0.97	0.04	0.96	FALSE
38	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SKA2	0.04	0.01	blup	42	0.02	1.7e-02	3.0	-5.5	4.1e-08	0.83	0.02	0.61	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM37	0.12	0.05	blup	62	0.09	1.3e-10	-7.3	6.2	4.7e-10	-0.89	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PPM1E	0.12	0.02	blup	88	0.07	7.0e-04	-6.9	-6.2	4.7e-10	0.77	0.03	0.65	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	TEX14	0.04	0.02	blup	77	0.04	4.1e-05	-7.2	6.1	1.0e-09	-0.86	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRIM37	0.05	0.03	blup	62	0.05	3.1e-06	-7.2	6.3	3.1e-10	-0.91	0.02	0.98	FALSE
43	The Cancer Genome Atlas	Soft Tissue Sarcoma	MTMR4	0.07	0.00	blup	40	0.03	6.6e-03	6.4	-7.3	4.2e-13	0.82	0.01	0.61	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	RAD51C	0.10	0.08	lasso	5	0.10	7.7e-10	3.3	5.4	6.3e-08	-0.62	0.38	0.61	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM37	0.05	0.03	blup	62	0.05	2.7e-05	-7.0	6.2	7.5e-10	-0.87	0.02	0.95	FALSE