[Hub]/) : Traits : LDL Cholesterol : ←

chr20:39,270,768-40,683,594

Best TWAS P=1.16e-19 · Best GWAS P=3.36e-19 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LPIN3 0.06 0.01 enet 27 0.03 5.4e-05 6.1 5.3 1.5e-07 0.49 0.44 0.46 FALSE
2 GTEx Artery Aorta LPIN3 0.08 0.08 enet 4 0.08 5.4e-05 6.1 6.7 2.3e-11 0.62 0.30 0.61 FALSE
3 GTEx Artery Tibial LPIN3 0.17 0.13 lasso 6 0.15 6.5e-12 6.8 8.1 8.1e-16 0.70 0.06 0.94 FALSE
4 GTEx Stomach LPIN3 0.11 0.05 lasso 3 0.05 1.4e-03 6.1 6.4 1.7e-10 0.56 0.08 0.39 FALSE
5 ROSMAP Brain Pre-frontal Cortex LPIN3 0.11 0.10 lasso 8 0.12 2.5e-15 6.1 7.1 1.2e-12 0.61 0.94 0.06 FALSE
6 The Cancer Genome Atlas Breast Invasive Carcinoma ZHX3 0.03 0.03 lasso 4 0.02 1.2e-05 8.3 -8.3 1.5e-16 -0.72 0.49 0.48 FALSE
7 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PRO0628 0.05 0.01 lasso 2 0.02 4.5e-03 4.3 6.9 4.0e-12 0.66 0.01 0.51 FALSE
8 The Cancer Genome Atlas Brain Lower Grade Glioma LPIN3 0.03 0.04 lasso 2 0.03 5.5e-04 6.8 7.0 2.0e-12 0.66 0.22 0.11 FALSE
9 The Cancer Genome Atlas Pancreatic Adenocarcinoma LPIN3 0.10 0.02 lasso 5 0.07 6.1e-04 6.7 7.2 8.6e-13 0.72 0.01 0.70 FALSE
10 The Cancer Genome Atlas Prostate Adenocarcinoma PLCG1 0.03 0.00 blup 35 0.02 3.5e-03 8.8 -6.9 5.8e-12 -0.88 0.01 0.83 FALSE
11 The Cancer Genome Atlas Prostate Adenocarcinoma ZHX3 0.05 0.06 lasso 2 0.05 2.6e-06 9.0 -9.1 1.2e-19 -1.00 0.00 1.00 TRUE
12 The Cancer Genome Atlas Thyroid Carcinoma LPIN3 0.04 0.03 blup 45 0.04 9.3e-05 6.8 5.8 6.1e-09 0.42 0.10 0.12 FALSE