[Hub]/) : Traits : Neuroticism (Nagel 2018) :

chr3:49,598,064-51,234,774

Best TWAS P=4.38e-08 · Best GWAS P=4.4e-08 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Cells Transformed fibroblasts SEMA3B-AS1 0.15 0.01 enet 3 0.00 3.9e-01 4.9 5.2 1.7e-07 0.95 0.02 0.94 FALSE
2 GTEx Esophagus Gastroesophageal Junction HYAL1 0.30 0.13 lasso 9 0.10 2.1e-04 5.1 5.2 2.5e-07 0.97 0.01 0.97 FALSE
3 GTEx Esophagus Mucosa CYB561D2 0.07 0.02 lasso 4 0.02 3.1e-02 5.4 -5.1 3.0e-07 -0.93 0.02 0.92 FALSE
4 GTEx Esophagus Muscularis HYAL1 0.11 0.08 lasso 5 0.05 3.3e-04 5.1 5.3 1.2e-07 0.99 0.01 0.99 FALSE
5 GTEx Muscle Skeletal HYAL1 0.08 0.08 lasso 3 0.06 7.6e-07 5.4 5.5 4.4e-08 1.00 0.01 0.99 TRUE
6 GTEx Nerve Tibial U73166.2 0.07 0.03 lasso 3 0.03 2.8e-03 5.4 -5.4 7.6e-08 -0.98 0.01 0.98 FALSE
7 GTEx Thyroid U73166.2 0.05 0.02 enet 6 0.01 5.9e-02 5.0 -5.2 2.1e-07 -0.95 0.01 0.96 FALSE
8 METSIM Adipose CYB561D2 0.09 0.08 lasso 5 0.07 3.8e-10 4.9 -5.2 1.7e-07 -0.94 0.02 0.98 FALSE
9 ROSMAP Brain Pre-frontal Cortex CACNA2D2 0.05 0.02 lasso 3 0.02 3.6e-03 5.5 -5.5 4.9e-08 -1.00 0.01 0.98 FALSE
10 ROSMAP Brain Pre-frontal Cortex SEMA3B 0.05 0.03 lasso 6 0.02 8.3e-04 4.9 5.2 2.5e-07 0.97 0.01 0.99 FALSE