Best TWAS P=4.38e-08 · Best GWAS P=4.4e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | SEMA3B-AS1 | 0.15 | 0.01 | enet | 3 | 0.00 | 3.9e-01 | 4.9 | 5.2 | 1.7e-07 | 0.95 | 0.02 | 0.94 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | HYAL1 | 0.30 | 0.13 | lasso | 9 | 0.10 | 2.1e-04 | 5.1 | 5.2 | 2.5e-07 | 0.97 | 0.01 | 0.97 | FALSE |
| 3 | GTEx | Esophagus Mucosa | CYB561D2 | 0.07 | 0.02 | lasso | 4 | 0.02 | 3.1e-02 | 5.4 | -5.1 | 3.0e-07 | -0.93 | 0.02 | 0.92 | FALSE |
| 4 | GTEx | Esophagus Muscularis | HYAL1 | 0.11 | 0.08 | lasso | 5 | 0.05 | 3.3e-04 | 5.1 | 5.3 | 1.2e-07 | 0.99 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Muscle Skeletal | HYAL1 | 0.08 | 0.08 | lasso | 3 | 0.06 | 7.6e-07 | 5.4 | 5.5 | 4.4e-08 | 1.00 | 0.01 | 0.99 | TRUE |
| 6 | GTEx | Nerve Tibial | U73166.2 | 0.07 | 0.03 | lasso | 3 | 0.03 | 2.8e-03 | 5.4 | -5.4 | 7.6e-08 | -0.98 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Thyroid | U73166.2 | 0.05 | 0.02 | enet | 6 | 0.01 | 5.9e-02 | 5.0 | -5.2 | 2.1e-07 | -0.95 | 0.01 | 0.96 | FALSE |
| 8 | METSIM | Adipose | CYB561D2 | 0.09 | 0.08 | lasso | 5 | 0.07 | 3.8e-10 | 4.9 | -5.2 | 1.7e-07 | -0.94 | 0.02 | 0.98 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | CACNA2D2 | 0.05 | 0.02 | lasso | 3 | 0.02 | 3.6e-03 | 5.5 | -5.5 | 4.9e-08 | -1.00 | 0.01 | 0.98 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | SEMA3B | 0.05 | 0.03 | lasso | 6 | 0.02 | 8.3e-04 | 4.9 | 5.2 | 2.5e-07 | 0.97 | 0.01 | 0.99 | FALSE |