TWAS hub - SEMA3B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.1466	0.0672	0.0073	0.098	NA	0.057	NA	0.080	7.0e-06	NA	0.00053	NA	4.6e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.0503	0.0250	0.0025	0.032	0.016	0.018	0.019	0.021	5.4e-05	0.0029	0.00180	0.0014	8.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Impedance of whole body	12.4	63.1	72.9	8.5	7.3
Impedance of leg (left)	12.0	58.3	64.0	7.2	8.0
Impedance of leg (right)	11.7	56.7	65.8	6.9	8.1
Impedance of arm (right)	11.5	53.8	72.2	8.5	6.0
Worry (Nagel 2018)	10.6	22.4	40.3	2.1	6.3
Impedance of arm (left)	9.9	45.7	62.9	7.9	5.3
Worrier / anxious feelings	9.2	17.5	28.5	2.5	5.3
Comparative body size at age 10	8.7	24.1	25.4	-4.8	-5.0
Smoking status: Previous	8.5	12.6	14.1	-3.8	-3.3
Pulse wave reflection index	8.0	9.8	15.9	-4.0	-1.9
Tense / ‘highly strung’	7.9	13.2	25.3	1.0	5.0
Nervous feelings	7.7	14.3	27.6	1.0	5.3
Frequency of depressed mood in last 2 weeks	7.6	10.7	21.3	0.4	4.6
Maternal smoking around birth	7.0	10.2	15.4	-3.9	-2.2
Neuroticism score	7.0	14.7	29.3	-0.2	5.4
Past tobacco smoking	6.7	12.4	16.4	4.0	2.9
Ever unenthusiastic/disinterested for a whole week	6.6	8.1	13.8	-1.5	3.7
Depression (Nagel 2018)	6.5	9.8	19.2	0.6	4.4
Neuroticism (2016)	6.1	8.8	17.0	0.8	4.1
Smoking Status	5.9	14.2	19.9	-4.5	-2.9
Chronotype (morning person)	5.9	13.7	26.3	1.0	-5.1
Pulse rate	5.8	9.7	11.3	3.4	2.9
Neuroticism (Nagel 2018)	5.6	13.3	26.6	-0.0	5.2
Ever highly irritable/argumentative for 2 days	5.6	6.8	12.2	-1.2	3.5
Pulse rate, automated reading	5.5	17.7	20.0	4.5	3.9
Frequency of unenthusiasm / disinterest in last 2 weeks	5.3	7.0	14.1	-0.1	3.8
Number of full sisters	5.2	6.4	12.5	-3.5	0.4
Neuroticism	4.8	11.5	22.8	-0.5	4.8
Exposure to tobacco smoke outside home	4.6	6.1	11.5	-3.4	-0.8
Miserableness	4.4	7.6	11.6	-1.9	3.4
Ever depressed for a whole week	4.3	5.3	6.2	-2.5	2.1
Exposure to tobacco smoke at home	4.2	4.7	9.0	-3.0	-0.7
Breastfed as a baby	4.2	5.2	10.2	-0.5	-3.2
Friendships satisfaction	4.2	5.2	8.0	1.6	2.8
Waist Hip Ratio (WHR)	4.1	18.3	31.9	2.2	5.7
Relative age of first facial hair	3.9	8.1	12.8	-3.6	1.8
Health satisfaction	3.9	5.1	10.2	-0.0	3.2
Ever smoked	3.9	6.9	10.8	-3.3	-1.7
Alcohol drinker status: Previous	3.9	4.5	4.6	-2.1	-2.1
Tinnitus: Yes, but not now, but have in the past	3.8	4.1	5.1	1.7	2.3
Hayfever, allergic rhinitis or eczema	3.8	8.2	8.4	2.8	2.9
Body mass index (BMI)	3.8	16.2	26.9	-5.2	-2.4
Number of live births	3.8	5.3	9.3	-3.0	-1.2
Age at last live birth	3.8	5.5	10.4	3.2	-0.8
Average weekly beer plus cider intake	3.8	5.5	9.2	-3.0	1.3
Severe depression (siblings)	3.7	4.2	8.4	-0.1	2.9
Illnesses of siblings: Diabetes	3.6	4.4	8.4	-0.7	2.9
Mood swings	3.6	6.5	11.6	-1.2	3.4
Eye problems/disorders: None of the above	3.5	4.0	7.6	0.7	-2.8
Suffer from ‘nerves’	3.5	5.4	8.3	1.6	2.9
Commuting to job workplace: Car/motor vehicle	3.5	4.0	7.7	-2.8	-0.6
Stomach or abdominal pain in last month	3.4	4.3	7.5	1.0	2.7
Serious illness, injury or assault of a close relative in last 2 years	3.4	3.9	5.5	-1.5	-2.3
Leg pain on walking	3.4	4.3	8.5	-2.9	-0.2
Commuting to job workplace: Walk	3.4	3.6	6.7	2.6	-0.7
Taking other prescription medications	3.3	5.1	7.9	-1.5	2.8
Frequency of tenseness / restlessness in last 2 weeks	3.3	5.2	9.7	-0.8	3.1
Number of operations (self-reported)	3.3	4.9	9.0	-3.0	0.9
Pack years of smoking	3.3	4.9	7.7	-1.4	-2.8
Age at First Birth	3.1	4.5	8.8	3.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	4.1	7.9	0.5	2.8
BMI	3.0	17.6	27.5	-5.2	-2.8
Bilateral oophorectomy (both ovaries removed)	3.0	3.5	6.8	-2.6	0.3
Had menopause	2.9	3.6	5.2	-1.4	-2.3
Mean Putamen Volume	2.8	3.2	4.2	1.4	2.0
Arm fat-free mass (right)	2.8	14.2	21.8	-4.7	-2.6
Overall health rating	2.8	6.1	11.8	-0.6	3.4
Qualifications: None of the above	2.7	5.8	11.4	-3.4	-0.4
Lupus	2.6	3.9	6.7	-2.6	-1.1
Average weekly spirits intake	2.6	3.2	3.3	1.8	1.8
Sensitivity / hurt feelings	2.6	4.5	8.1	-0.9	2.9
Eye problems/disorders: Diabetes related eye disease	2.6	2.9	5.5	0.4	2.4
Illnesses of siblings	2.6	3.6	6.8	-0.7	-2.6
Birth weight of first child	2.6	4.8	6.3	-1.8	-2.5
Trunk fat-free mass	2.5	14.1	20.9	-4.6	-2.7
Medication: Ibuprofen	2.5	3.0	4.6	-2.1	-1.2
Breast cancer (self-reported)	2.5	3.0	4.0	-1.4	-2.0
Arm predicted mass (left)	2.5	12.8	21.7	-4.7	-1.9
Body Mass Index (BMI) (2010)	2.4	3.2	5.3	-2.3	-1.1
Lung FVC	2.4	12.2	19.5	-2.2	-4.4
Leg predicted mass (left)	2.4	12.5	17.0	-4.1	-2.8
Trunk predicted mass	2.4	13.7	20.0	-4.5	-2.7
Arm predicted mass (right)	2.4	12.4	20.6	-4.5	-2.0
Whole body fat-free mass	2.4	13.8	20.0	-4.5	-2.8
Ever had bowel cancer screening	2.4	2.8	4.1	2.0	-1.2
Whole body water mass	2.4	13.7	20.1	-4.5	-2.7
Leg predicted mass (right)	2.4	12.6	15.1	-3.9	-3.2
Medication: Atorvastatin	2.4	3.0	4.5	-2.1	-1.2
Arm fat-free mass (left)	2.4	12.1	20.3	-4.5	-2.0
Pack years adult smoking proportion	2.3	3.6	5.8	-1.2	-2.4
Age when periods started (menarche)	2.3	5.5	11.0	-3.3	-0.2
Hip circumference	2.3	10.1	15.4	-3.9	-2.2
Age at first live birth	2.3	4.1	8.2	2.9	0.0
Leg fat-free mass (right)	2.3	12.3	15.3	-3.9	-3.1
Number of self-reported non-cancer illnesses	2.3	4.0	7.9	-0.1	2.8
Bipolar Disorder (2018)	2.2	3.5	5.9	-2.4	1.0
Leg fat-free mass (left)	2.2	11.8	16.0	-4.0	-2.8
Number of incorrect matches in round	2.2	3.6	6.2	0.9	-2.5
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	7.0	0.4	2.6
Average weekly red wine intake	2.2	3.3	5.4	1.1	-2.3
Depressed Affect (Nagel 2018)	2.1	4.4	7.4	-1.1	2.7
Type 2 Diabetes (T2D) (2018)	2.1	4.0	7.0	-2.6	1.0
Allergy	2.1	4.9	8.3	-1.2	-2.9
Alcohol intake versus 10 years previously	2.1	3.2	3.9	-1.6	2.0
Hair/balding pattern: Pattern 3	2.1	3.1	6.1	2.5	-0.4
Happiness	2.1	2.6	4.9	-0.6	2.2
Had major operations	2.1	2.5	3.1	-1.8	1.4
Basal metabolic rate	2.1	11.4	18.6	-4.3	-2.0
Hayfever/allergic rhinitis (self-reported)	2.0	2.7	3.5	1.4	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	6.0	-0.1	2.5
Pulse wave peak to peak time	2.0	2.3	4.6	2.1	0.3
Falls in the last year	1.9	2.5	3.6	-1.9	-1.2
Noisy workplace	1.9	2.3	3.1	-1.8	1.2
Family relationship satisfaction	1.9	2.4	4.6	-0.4	2.2
Eye problems/disorders: Glaucoma	1.9	2.2	3.6	0.9	1.9
Lung cancer (father)	1.8	2.1	4.1	-2.0	-0.2
Worry too long after embarrassment	1.8	3.1	5.4	-0.9	2.3
Qualifications: College or University degree	1.8	5.8	11.6	3.4	0.2
Long-standing illness, disability or infirmity	1.8	2.8	5.5	-2.3	0.4
HDL Cholesterol	1.7	2.8	3.4	1.9	-1.4
Schizophrenia (2014)	1.7	3.7	7.5	-2.7	0.0
Relative age voice broke	1.7	2.5	4.9	-2.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.8	6.3	1.2	2.5
Weight	1.7	8.4	15.6	-4.0	-1.1
Prospective memory result	1.7	2.1	3.1	1.1	1.8
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	2.7	1.6	1.7
Birth weight	1.7	3.7	6.7	-0.9	-2.6
Ever taken oral contraceptive pill	1.7	1.9	2.7	-1.6	-1.0
Age started oral contraceptive pill	1.7	2.1	3.9	2.0	-0.6
Bipolar Disorder or Schizophrenia	1.6	4.0	7.7	-2.8	0.5
Blood Platelet Count	1.6	19.0	32.5	-2.3	-5.7
Blood Red Count	1.6	15.7	19.1	3.5	4.4
Hair/balding pattern: Pattern 2	1.6	2.1	2.3	-1.4	1.5
Diabetes (self-reported)	1.6	2.5	4.8	-2.2	0.5
Chronic bronchitis/emphysema (mother)	1.6	1.9	3.7	-1.9	0.1
Emphysema/chronic bronchitis	1.6	1.8	2.1	-1.3	-1.4
Diabetes diagnosed by doctor	1.6	2.6	5.0	-2.2	0.5
Pain type(s) experienced in last month: Hip pain	1.6	2.0	3.2	-1.8	-0.9
High cholesterol (Self-reported)	1.6	2.8	5.5	0.2	-2.3
Crohns Disease (2017)	1.5	3.3	3.7	-1.7	-1.9
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	1.9	1.4	1.2
Chronic bronchitis/emphysema (father)	1.5	1.8	2.4	-1.1	1.5
Medication: Simvastatin	1.5	2.1	4.0	-0.6	-2.0
Pulse wave Arterial Stiffness index	1.5	1.7	3.4	-1.8	-0.2
Loud music exposure frequency	1.5	1.6	2.7	-0.8	1.6
Neck or shoulder pain in last month	1.5	2.1	4.3	-2.1	-0.0
Knee pain experienced in last month	1.5	2.3	4.4	-2.1	-0.4
Mother’s age at death	1.5	1.9	2.1	1.5	1.3
Leg fat mass (left)	1.5	5.7	11.4	-3.4	0.2
Systolic blood pressure, automated reading	1.4	4.1	5.1	-2.3	-1.7
Medication: Metformin	1.4	2.0	3.9	-2.0	-0.4
Fed-up feelings	1.4	2.6	5.1	0.2	2.3
Waist circumference	1.4	5.1	10.2	-3.2	0.1
Had other major operations	1.4	1.7	2.6	-1.6	0.9
Medication: Cholesterol lowering	1.4	2.2	3.6	-0.9	-1.9
Number of children fathered	1.4	1.6	3.1	-1.8	0.0
Leg fat mass (right)	1.4	5.5	10.8	-3.3	0.3
Supplements: Fish oil (including cod liver oil)	1.4	1.9	3.2	0.7	-1.8
LDL Cholesterol	1.3	2.0	3.5	-0.7	-1.9
Diabetes (father)	1.3	1.6	2.5	-0.8	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	2.5	-1.6	-0.9
Peak expiratory flow (PEF)	1.3	3.1	4.3	-1.4	-2.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	2.4	1.4	1.5
Mouth/teeth dental problems: Dentures	1.2	2.0	3.0	-1.7	-0.9
Hair/balding pattern: Pattern 4	1.2	2.9	4.8	-1.0	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.0	-1.4	-0.9
Medication: Aspirin	1.2	1.6	3.2	-0.2	-1.8
Medication: Aspirin	1.2	1.5	3.0	-0.2	-1.7
Arm fat mass (left)	1.2	4.9	9.7	-3.1	-0.3
Financial situation satisfaction	1.2	1.5	1.7	-1.3	1.1
Irritability	1.2	2.0	2.3	-1.3	1.5
Prostate Cancer	1.1	1.5	3.0	0.0	1.7
Medication: Amlodipine	1.1	1.6	2.9	-0.5	-1.7
Wheeze or whistling in the chest in last year	1.1	2.0	3.8	0.6	1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	4.6	0.3	2.1
Guilty feelings	1.1	1.7	2.5	-1.6	1.0
Ever had prostate specific antigen (PSA) test	1.1	1.3	1.7	1.3	1.0
Pain experienced in last month	1.1	1.8	3.4	1.8	0.4
Breast Cancer	1.0	2.5	4.7	-0.5	-2.2
Hand grip strength (left)	1.0	2.6	5.0	0.4	-2.2
Townsend deprivation index at recruitment	1.0	1.4	1.6	-1.1	-1.3
Mouth/teeth dental problems	1.0	1.5	2.7	1.7	0.5
Heart attack	1.0	1.3	1.4	-1.1	-1.2
Arm fat mass (right)	1.0	4.1	8.2	-2.9	-0.2
High blood pressure (siblings)	1.0	1.4	2.6	-0.5	1.6
Leg fat percentage (right)	1.0	3.6	4.3	-2.1	1.7
Medication: Omeprazole	1.0	1.2	1.4	-1.2	1.0
Medication: Gliclazide	1.0	1.2	2.4	-0.0	1.5
Heart attack/myocardial infarction (self-reported)	1.0	1.2	1.6	-1.0	-1.3
Fasting Glucose	0.9	1.1	2.2	1.5	0.1
Rheumatoid Arthritis	0.9	1.3	2.0	1.4	0.7
Allergy or Eczema	0.9	2.5	2.9	1.7	1.5
Lung FEV1/FVC ratio	0.9	4.7	7.0	-2.6	1.5
Financial difficulties in last 2 years	0.9	1.2	2.3	-0.1	1.5
Father’s age at death	0.9	1.2	2.3	-0.5	-1.5
Mean time to correctly identify matches	0.9	1.7	2.4	-1.0	-1.5
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.1	1.4	-0.1
Fractured/broken bones in last 5 years	0.9	1.2	1.6	-1.3	-0.9
Alzheimer’s Disease (in mother)	0.8	1.0	1.8	-1.3	0.3
Crohns Disease (2012)	0.8	1.2	2.3	-0.3	-1.5
Number of treatments/medications taken	0.8	1.5	2.5	-0.7	1.6
Hand grip strength (right)	0.8	2.2	4.3	-0.3	-2.1
Qualifications: CSEs or equivalent	0.8	1.0	2.0	-1.4	0.0
Medication: Ramipril	0.8	1.1	1.9	-1.4	-0.5
Asthma	0.8	1.6	2.7	-0.7	1.6
Depression (self-reported)	0.8	1.0	1.9	-0.2	1.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.1	-1.5	0.1
Number of full brothers	0.8	1.0	1.8	-1.4	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.3	1.1	0.7
Medication: Blood pressure	0.8	1.5	1.8	-1.3	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.8	-0.1	1.3
Wears glasses or contact lenses	0.8	0.9	1.6	-1.3	-0.4
Illnesses of father: High blood pressure	0.8	1.0	1.0	-1.0	1.0
Leg fat percentage (left)	0.8	2.9	3.8	-1.9	1.4
Cholesterol lowering medication	0.8	1.1	1.8	-1.3	-0.7
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.4	-0.3	-1.8
Heel T-Score	0.7	5.8	7.0	2.6	2.1
Medication: Co-codamol	0.7	0.8	1.6	-1.3	-0.0
Current tobacco smoking	0.7	1.2	2.0	-1.4	-0.7
Pain all over the body in last month	0.7	0.7	1.1	-1.0	0.6
Medication: Lansoprazole	0.7	0.8	1.5	-0.1	1.2
Shortness of breath walking on level ground	0.7	0.8	1.3	-0.5	1.1
Whole body fat mass	0.7	2.8	5.1	-2.3	0.7
Loneliness, isolation	0.7	1.0	1.7	-0.6	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.3	-1.1	-0.5
Asthma (self-reported)	0.7	1.4	2.4	-0.7	1.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.2	-0.8	1.1
Basal cell carcinoma (self-reported)	0.7	0.8	1.6	0.1	-1.3
Heart disease (siblings)	0.7	0.9	1.4	1.2	0.6
Schizophrenia (2018)	0.6	1.3	2.5	-1.6	-0.2
Schizophrenia vs Biploar Disorder	0.6	0.9	1.7	0.1	-1.3
Blood Eosinophil Count	0.6	4.5	4.9	-2.0	2.2
Height	0.6	12.2	14.1	3.2	3.8
Respiratory disease	0.6	1.4	2.0	-0.9	1.4
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	-1.1	0.6
Vitamin and mineral supplements	0.6	0.8	0.9	-0.8	-0.9
Trunk fat percentage	0.6	2.6	5.1	0.2	2.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.2	0.5	1.5
Hearing difficulty/problems with background noise	0.6	1.0	1.3	-0.9	-1.1
Time employed in main current job	0.6	0.7	1.3	-0.3	-1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.4	1.6	-0.5
Blood clot in the leg (DVT)	0.6	0.8	0.9	-1.0	0.8
Glaucoma (self-reported)	0.6	0.7	0.7	0.8	0.8
Medication for pain relief, constipation, heartburn	0.6	1.1	2.0	1.4	0.4
Alcohol intake frequency.	0.6	1.4	1.8	-1.3	1.0
Comparative height size at age 10	0.6	3.3	6.1	2.5	0.6
Chest pain or discomfort	0.6	0.8	1.3	0.6	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.4	0.2	1.2
Osteoarthritis (self-reported)	0.6	0.8	1.6	-0.2	1.2
Commuting to job workplace: Public transport	0.6	0.7	1.0	1.0	-0.6
Unable to work because of sickness or disability	0.6	0.8	1.4	-0.4	1.2
Vascular/heart problems diagnosed by doctor	0.6	1.6	2.4	1.6	0.9
Irritable Bowel Disease (IBD)	0.5	1.3	1.9	-0.8	-1.4
Ovarian Cancer	0.5	0.7	1.3	1.1	-0.3
High blood pressure	0.5	1.3	1.6	-1.2	-1.1
Medication: Levothyroxine sodium	0.5	0.9	1.0	-1.0	0.9
Arm fat percentage (right)	0.5	1.9	3.2	-1.8	0.8
Standing height	0.5	4.7	5.6	1.9	2.4
Body fat percentage	0.5	2.1	3.8	-0.7	1.9
Medication: Seretide 50 evohaler	0.5	0.6	1.0	-0.4	1.0
Arm fat percentage (left)	0.5	2.0	3.6	-1.9	0.6
Eye problems/disorders: Cataract	0.5	0.5	1.0	-1.0	0.3
Smoking status: Current	0.5	0.7	1.4	-1.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.7	-0.6	-1.3
Diastolic blood pressure, automated reading	0.5	1.5	2.5	-1.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	0.7	-0.8	0.8
Coronary Artery Disease (CAD)	0.4	0.5	0.7	-0.5	-0.9
Ulcerative Colitis	0.4	0.6	0.8	0.7	-0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	0.2	0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.6	0.8	-0.9	-0.5
Angina	0.4	0.5	1.0	1.0	0.3
Supplements: Zinc	0.4	0.4	0.6	0.8	-0.5
Diabetes (mother)	0.4	0.5	0.8	-0.4	0.9
Trunk fat mass	0.4	1.7	1.8	-1.4	1.2
Length of working week for main job	0.4	0.5	0.5	-0.6	-0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.7	-0.8	-0.5
Angina (self-reported)	0.4	0.5	0.9	0.9	-0.2
Migraine (self-reported)	0.4	0.5	0.8	-0.9	0.4
Medication: Allopurinol	0.4	0.5	1.0	-0.0	1.0
Supplements: Vitamin C	0.4	0.4	0.8	0.9	-0.2
Hypertension (Self-reported)	0.4	1.2	1.8	-1.3	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.2	-1.1	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	-0.2	1.0
Mineral and other dietary supplements	0.4	0.5	1.1	0.1	1.0
Osteoporosis (self-reported)	0.4	0.5	0.9	-0.2	-1.0
Medication: Bendroflumethiazide	0.4	0.6	1.0	0.5	-1.0
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	-0.9	-0.0
Bipolar Disorder (2011)	0.3	0.3	0.7	0.0	-0.8
Medication for hormone replacement therapy	0.3	0.4	0.4	-0.6	-0.7
Fluid intelligence score	0.3	0.7	1.4	-0.0	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.5	-1.2	-0.5
Medication: Paracetamol	0.3	0.5	0.5	-0.7	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	-0.8	0.5
Heart disease (mother)	0.3	0.4	0.7	0.1	-0.8
Qualifications: nursing, teaching	0.3	0.5	0.9	0.9	-0.3
Average weekly champagne plus white wine intake	0.3	0.4	0.8	0.9	0.0
Medication: Paracetamol	0.3	0.5	0.7	-0.6	0.8
Risk taking	0.3	0.4	0.7	-0.8	-0.4
Ulcerative Colitis (UC)	0.2	0.4	0.5	0.7	-0.6
Reaction Time	0.2	0.5	0.7	-0.9	-0.4
Primary Biliary Cirrhosis	0.2	0.3	0.3	0.6	-0.4
Triglycerides	0.2	0.4	0.7	0.0	-0.9
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.2	-0.6
Systolic Blood Pressure	0.2	1.0	1.9	-1.4	0.0
Hypothyroidism (self reported)	0.2	0.4	0.8	-0.1	0.9
Supplements: Glucosamine	0.2	0.3	0.3	0.6	-0.5
Sitting height	0.2	1.5	1.9	1.1	-1.4
Alcohol usually taken with meals	0.2	0.3	0.7	0.8	0.2
Illnesses of mother	0.2	0.2	0.3	0.6	-0.3
Headache pain in last month	0.2	0.3	0.6	0.0	0.8
Gout (self-reported)	0.2	0.2	0.5	0.0	0.7
Illnesses of father: Heart disease	0.2	0.3	0.4	-0.6	-0.5
Back pain experienced in last month	0.2	0.3	0.4	0.5	0.6
Hearing aid user	0.2	0.3	0.4	-0.7	0.3
Commuting to job workplace: Cycle	0.2	0.2	0.4	0.6	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	0.2	-0.9
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.4	-0.0
HbA1C	0.1	0.2	0.3	0.0	-0.6
Cardiovascular Disease	0.1	0.5	1.0	-1.0	-0.1
Hair Pigment	0.1	2.5	3.7	-1.9	-1.1
Tanning	0.1	0.7	1.5	0.1	-1.2
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.5	0.3
Average weekly fortified wine intake	0.1	0.1	0.1	0.4	-0.4
Serious illness, injury or assault to yourself	0.1	0.1	0.1	0.4	-0.2
Medication: Atenolol	0.1	0.1	0.2	-0.4	0.3
Forced vital capacity (FVC)	0.1	0.2	0.3	0.3	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.2	-0.5	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.3	0.5
Forced vital capacity (FVC), Best measure	0.1	0.5	1.0	-0.1	-1.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.1	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.2	0.5	-0.3
Myopia	0.1	0.1	0.2	0.0	0.4
Supplements: Calcium	0.1	0.1	0.1	0.2	-0.3
Major Depression (MDD)	0.0	0.0	0.0	0.1	0.0
Blood White Count	0.0	0.1	0.1	-0.3	0.4
Multivitamins +/- minerals	0.0	0.0	0.1	0.3	0.1
High blood pressure (mother)	0.0	0.0	0.1	-0.2	-0.2
Medication for cholesterol	0.0	0.1	0.1	0.3	0.0
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	-0.3	0.1
Medication: Blood pressure	0.0	0.0	0.1	-0.2	0.0
Medication: Lisinopril	0.0	0.0	0.0	-0.0	0.1
Alcohol drinker status: Never	0.0	0.0	0.1	0.1	0.3

Hub : Genes

SEMA3B

Models

Trait associations