Hub : Genes

CACNA2D2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.1760	0.0730	5.3e-04	0.014	NA	0.031	NA	0.017	1.4e-01	NA	5.4e-02	NA	1.2e-01
2	GTEx	Testis	0.0760	0.0390	9.8e-04	0.059	NA	0.041	NA	0.046	1.3e-03	NA	6.2e-03	NA	4.1e-03
3	ROSMAP	Brain Pre-frontal Cortex	0.0501	0.0286	3.5e-03	0.016	0.011	0.014	0.015	0.016	3.4e-03	1.1e-02	6.0e-03	0.0045	3.6e-03
4	TCGA	Prostate Adenocarcinoma	0.0421	0.0216	3.2e-05	0.066	0.040	0.043	NA	0.062	2.1e-07	5.1e-05	2.3e-05	NA	4.6e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.1	1.8	2.7	-0.8	-1.6	-1.1	-1.6
Bipolar Disorder or Schizophrenia	0.7	1.8	3.6	-0.8	-1.9	-0.9	-1.4
Depressed Affect (Nagel 2018)	2.2	4.7	8.9	0.8	-1.8	-3.0	-2.4
Depression (Nagel 2018)	7.9	11.9	20.5	2.3	-3.4	-4.5	-3.2
Intelligence (Savage-Jansen 2018)	1.0	3.0	8.2	-1.2	2.9	0.8	1.3
Neuroticism (Nagel 2018)	6.0	14.1	29.7	2.8	-3.2	-5.5	-2.9
Schizophrenia (2018)	0.2	0.5	1.4	-0.4	-1.2	-0.3	-0.4
Schizophrenia vs Biploar Disorder	1.1	1.4	2.8	-0.9	1.7	1.2	0.7
Worry (Nagel 2018)	9.5	20.1	41.2	3.4	-4.1	-6.4	-3.3
Alzheimer’s Disease (in mother)	0.1	0.1	0.5	-0.7	-0.2	0.1	-0.0
Alzheimer’s Disease (in father)	0.6	0.6	2.1	-1.5	0.2	-0.1	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	1.7	-1.3	-0.0	0.1	-0.5
Crohns Disease (2017)	1.1	2.4	5.1	-1.2	1.8	2.2	0.0
Irritable Bowel Disease (IBD)	0.6	1.5	3.2	-0.9	1.5	1.8	0.0
Ulcerative Colitis (UC)	0.4	0.7	1.0	-0.5	1.0	0.9	0.8
Major Depression (MDD)	2.0	2.4	5.3	2.3	-1.6	-1.3	0.0
Reaction Time	2.9	5.6	11.3	-1.8	2.7	0.8	3.4
Verbal and Numeric Reasoning (VNR)	2.3	5.6	10.4	-2.3	3.2	1.8	1.9
Breast Cancer	3.0	7.1	13.3	-2.2	3.6	2.4	2.1
Ovarian Cancer	0.5	0.7	2.0	0.0	0.9	0.3	1.4
Prostate Cancer	2.0	2.8	4.5	1.2	-2.1	-1.8	-1.4
Age at First Birth	0.2	0.3	1.1	1.1	-0.2	-0.3	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.1	0.0	0.0	0.3	0.0
Body Mass Index (BMI) (2010)	3.5	4.8	9.7	-3.1	2.2	1.1	1.9
Coronary Artery Disease (CAD)	0.2	0.3	0.7	-0.3	0.5	0.8	0.2
Crohns Disease (2012)	1.4	2.3	3.2	-1.7	1.8	1.6	0.7
Mean Putamen Volume	3.5	4.0	6.2	1.6	-2.4	-2.5	-1.1
Fasting Glucose	0.4	0.4	1.0	-0.3	1.0	-0.4	0.7
HbA1C	0.4	0.4	1.1	-0.5	0.5	1.0	0.4
HDL Cholesterol	0.9	1.5	2.5	-0.1	1.6	1.2	1.5
LDL Cholesterol	0.5	0.8	2.3	0.4	0.0	1.5	-0.8
Lupus	1.9	2.9	5.2	0.3	-2.3	1.1	-2.2
Neuroticism (2016)	4.7	6.7	13.6	2.3	-1.6	-3.7	-2.4
Primary Biliary Cirrhosis	0.3	0.4	1.1	-0.7	1.1	-0.1	0.3
Rheumatoid Arthritis	0.5	0.7	1.3	-0.8	1.1	-0.6	0.7
Schizophrenia (2014)	0.2	0.5	1.1	-0.7	-1.0	-0.3	-0.4
Triglycerides	1.4	2.3	3.4	1.6	-1.5	0.9	-1.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	0.5	-0.1	0.7	-0.8
Ulcerative Colitis	1.7	2.5	4.3	-1.3	2.1	1.2	1.6
Blood Eosinophil Count	4.6	35.2	80.8	4.9	-9.0	-2.2	-5.6
Blood Platelet Count	2.0	23.3	34.9	-4.4	4.9	5.9	3.9
Blood Red Count	2.1	20.7	31.9	5.7	-4.1	-3.6	-4.6
Blood White Count	0.3	2.1	3.4	1.9	-1.5	0.3	-1.6
Heel T-Score	0.8	6.3	10.6	3.3	-1.5	-1.5	-3.2
BMI	5.0	28.8	49.1	-7.0	5.9	3.1	4.7
Height	5.1	98.6	158.8	7.7	-12.6	-4.5	-12.5
Waist Hip Ratio (WHR)	5.6	25.4	33.4	4.1	-5.6	-5.8	-4.4
Systolic Blood Pressure	2.2	11.1	17.1	3.6	-3.7	0.0	-4.1
Smoking Status	1.8	4.3	8.8	-2.0	1.4	3.0	1.5
Allergy or Eczema	2.3	6.1	13.1	2.0	-3.6	-1.8	-1.9
Cardiovascular Disease	0.4	1.3	2.9	1.3	-0.5	0.5	-1.7
Hypothyroidism (self reported)	0.1	0.3	0.7	0.9	-0.2	-0.5	0.2
Respiratory disease	1.2	2.8	7.7	0.8	-2.8	-1.6	-0.5
Type 2 Diabetes (T2D) (2018)	0.8	1.4	3.9	0.5	-1.0	-0.7	-2.0
Lung FEV1/FVC ratio	0.9	4.5	8.2	0.3	-2.7	-1.6	-2.9
Lung FVC	5.1	26.0	35.5	-4.8	5.1	4.3	6.0
Neuroticism	4.9	11.9	24.9	2.3	-2.8	-5.0	-3.1
Chronotype (morning person)	11.6	26.8	39.9	-4.3	6.3	5.2	4.6
Hair Pigment	0.0	0.7	1.8	-0.7	0.7	1.3	0.5
Tanning	0.0	0.5	1.3	0.6	-0.4	1.1	-0.3
Hand grip strength (left)	0.7	1.9	4.8	-0.4	0.2	2.2	-1.5
Number of treatments/medications taken	0.8	1.5	2.7	0.2	-1.6	-1.6	-0.8
Average weekly spirits intake	2.3	2.8	4.6	1.3	-1.9	-2.1	-1.1
Sensitivity / hurt feelings	2.6	4.4	8.0	1.5	-1.7	-2.8	-2.1
Frequency of depressed mood in last 2 weeks	7.0	9.7	24.2	1.2	-2.9	-4.9	-2.2
Hearing difficulty/problems: Yes	0.3	0.4	0.6	-0.7	0.5	-0.8	0.6
Relative age of first facial hair	8.1	16.7	25.7	3.4	-5.1	-2.2	-5.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.7	-0.2	-0.0	-1.3	0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	-0.8	-0.6	0.5	0.1
Ever had hysterectomy (womb removed)	0.4	0.5	0.8	0.4	-0.8	-0.5	-0.9
Systolic blood pressure, automated reading	0.4	1.2	3.0	0.7	-0.6	1.7	-0.9
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.1	-0.2	0.8	-2.0	0.8
Angina	0.3	0.3	0.8	-0.1	0.9	-0.4	0.6
Medication for hormone replacement therapy	1.4	1.6	3.1	0.3	-1.8	0.6	-1.6
Vitamin and mineral supplements	2.3	3.2	8.0	-0.9	2.8	1.4	1.5
Supplements: Zinc	0.3	0.3	0.5	-0.7	0.1	0.5	0.7
Medication: Co-codamol	0.1	0.1	0.3	-0.6	0.4	-0.0	0.1
Medication: Metformin	0.2	0.3	0.5	0.0	0.7	0.7	-0.5
Diabetes (father)	0.5	0.7	1.7	0.3	-0.8	-1.3	-0.5
Diabetes (mother)	2.0	2.6	4.9	2.2	-1.8	-0.8	-1.3
Severe depression (siblings)	4.8	5.4	8.4	1.6	-2.4	-2.9	-2.2
Pack years adult smoking proportion	5.2	7.9	12.1	-1.8	2.8	2.9	3.5
Impedance of leg (right)	19.9	96.4	132.2	11.5	-10.0	-8.1	-9.4
Leg fat-free mass (left)	1.6	8.6	18.9	-4.3	2.3	2.8	1.5
Trunk fat percentage	0.4	1.7	3.2	0.9	-0.5	-1.8	-1.6
Hand grip strength (right)	1.0	2.6	6.2	-0.1	-0.7	2.0	-2.5
Townsend deprivation index at recruitment	0.4	0.6	1.4	0.8	0.5	1.2	0.5
Current tobacco smoking	0.6	1.0	1.5	-1.1	0.9	0.8	1.2
Average weekly fortified wine intake	0.4	0.5	1.0	0.8	-1.0	0.3	-0.1
Maternal smoking around birth	4.0	5.8	11.1	-3.3	1.9	2.6	1.3
Fed-up feelings	1.8	3.3	5.9	0.6	-1.4	-2.4	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	7.3	9.7	15.8	2.4	-2.9	-4.0	-2.9
Relative age voice broke	4.2	6.4	11.6	2.1	-3.0	-0.7	-3.4
Taking other prescription medications	5.8	9.0	14.4	1.9	-3.8	-2.9	-3.1
Age when periods started (menarche)	6.5	15.6	30.4	2.3	-5.1	-0.4	-5.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	-0.8	-0.4	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	5.7	1.8	-1.7	-1.1	-2.4
Tinnitus: Yes, but not now, but have in the past	3.4	3.6	6.4	0.7	-1.8	-2.5	-2.1
Qualifications: CSEs or equivalent	2.4	3.1	5.4	1.6	-2.1	-0.4	-2.3
Serious illness, injury or assault to yourself	0.1	0.2	0.4	-0.5	0.1	-0.1	0.6
High blood pressure	0.3	0.8	2.0	0.9	-0.1	1.4	-0.5
Hayfever, allergic rhinitis or eczema	4.5	9.8	16.5	2.3	-4.1	-3.1	-2.7
Multivitamins +/- minerals	1.8	2.2	7.0	0.7	-2.6	-0.5	-1.1
Stomach or abdominal pain in last month	4.5	5.6	8.0	2.8	-2.1	-2.7	-1.7
Supplements: Glucosamine	0.6	0.8	1.5	0.7	-1.1	0.3	-1.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.8	0.6	-0.3	-1.3	-0.2
Medication: Atenolol	0.6	0.7	1.8	1.4	-0.9	0.0	-0.6
Medication: Levothyroxine sodium	0.1	0.2	0.4	-0.3	0.1	-0.6	0.4
Sitting height	0.7	5.0	8.7	1.1	-2.9	1.2	-3.0
Chronic bronchitis/emphysema (father)	1.0	1.2	2.4	0.6	-1.0	-1.5	-1.0
High blood pressure (mother)	0.2	0.3	1.3	1.1	-0.3	-0.2	0.1
Body mass index (BMI)	4.6	19.5	28.4	-5.3	5.1	2.8	4.0
Impedance of leg (left)	18.8	91.4	123.2	11.1	-9.6	-7.9	-9.3
Leg predicted mass (left)	1.6	8.7	18.9	-4.3	2.3	2.9	1.4
Trunk fat mass	0.1	0.6	1.7	-0.2	-0.3	-0.8	-1.3
Waist circumference	0.4	1.3	3.3	-1.8	1.2	0.2	0.5
Number of incorrect matches in round	3.1	5.2	7.1	-1.8	2.1	2.4	2.7
Past tobacco smoking	1.3	2.4	7.9	1.1	-0.2	-2.8	-0.6
Alcohol usually taken with meals	0.3	0.5	0.8	0.8	-0.9	-0.3	-0.8
Nervous feelings	7.7	14.4	27.8	2.7	-3.7	-5.3	-3.1
Frequency of tenseness / restlessness in last 2 weeks	4.1	6.4	12.2	0.9	-2.4	-3.5	-2.6
Hearing difficulty/problems with background noise	0.4	0.6	1.2	-0.2	0.9	1.1	0.7
Hair/balding pattern: Pattern 2	0.5	0.7	2.0	0.2	-0.8	-1.4	-0.1
Had menopause	6.3	7.9	10.5	-3.2	2.7	1.8	3.2
Had other major operations	0.6	0.8	1.6	-0.3	-1.3	-1.2	-0.2
Forced vital capacity (FVC)	0.1	0.2	0.5	-0.3	-0.7	0.4	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	5.8	2.2	-2.2	-2.1	-2.4
Ever unenthusiastic/disinterested for a whole week	6.5	8.0	15.1	1.4	-2.7	-3.9	-2.8
Qualifications: None of the above	0.2	0.5	0.9	0.3	-1.0	0.4	-0.9
Financial difficulties in last 2 years	1.6	2.2	3.6	1.9	-1.1	-1.7	-1.1
Mouth/teeth dental problems	0.6	0.9	1.5	-1.0	1.2	-0.3	0.9
Heart attack	0.6	0.8	1.3	-0.9	1.1	1.1	-0.1
Allergy	4.2	9.8	20.7	-1.5	4.6	3.1	2.5
Pain all over the body in last month	0.4	0.4	0.8	-0.9	0.5	-0.4	0.6
Diabetes (self-reported)	0.0	0.0	0.1	-0.0	0.0	-0.2	-0.4
Hayfever/allergic rhinitis (self-reported)	4.2	5.5	8.7	1.9	-2.5	-1.8	-2.9
Medication: Ramipril	0.6	0.8	1.6	-0.7	0.8	0.6	1.3
Medication: Simvastatin	2.0	3.0	5.6	-0.7	1.9	2.4	1.5
Fluid intelligence score	0.5	1.1	2.6	-0.8	1.6	0.9	0.2
Illnesses of siblings	2.9	4.0	7.7	-2.4	1.5	2.8	0.6
Neuroticism score	7.5	15.7	33.4	2.4	-3.2	-5.8	-3.6
Weight	0.5	2.4	6.8	-2.6	1.0	1.3	0.1
Impedance of arm (right)	10.6	49.3	64.8	8.1	-7.2	-6.2	-6.6
Arm fat percentage (right)	0.8	3.0	5.4	-2.1	2.3	-0.3	1.5
Trunk fat-free mass	0.7	4.1	9.3	-3.1	0.5	2.6	0.0
Hip circumference	1.7	7.1	10.5	-3.2	3.0	2.3	1.9
Time employed in main current job	7.1	8.2	15.3	-3.2	3.9	1.3	2.2
Alcohol intake versus 10 years previously	3.1	4.6	7.1	1.2	-2.3	-2.2	-2.7
Father’s age at death	0.7	1.0	2.1	-0.9	0.8	1.5	0.4
Worrier / anxious feelings	5.6	10.6	27.7	2.0	-2.2	-5.3	-2.4
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.2	8.1	2.5	-2.2	-2.8	-2.4
Falls in the last year	1.7	2.3	4.2	-1.6	1.2	1.1	2.0
Hair/balding pattern: Pattern 3	0.3	0.4	1.1	1.0	0.3	0.7	0.2
Number of live births	0.8	1.2	3.9	-2.0	0.4	0.8	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.0	0.2	-1.7	-0.6	-0.9
Pulse rate	1.4	2.4	5.4	1.6	-0.6	-2.3	-1.1
Happiness	3.0	3.7	5.4	1.6	-1.6	-2.3	-2.0
Noisy workplace	0.4	0.4	1.3	-0.6	-0.3	-1.1	0.0
Qualifications: A levels/AS levels or equivalent	1.0	2.3	4.2	-0.8	2.1	0.6	2.0
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	4.4	-1.4	1.4	2.1	0.5
Mouth/teeth dental problems: Dentures	0.5	0.9	1.9	-1.4	0.5	1.0	0.6
Asthma	2.0	3.8	10.0	0.9	-3.2	-1.9	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.6	-0.1	0.7	-0.3
Medication: Cholesterol lowering	1.3	2.0	5.2	-0.7	1.5	2.3	0.1
Depression (self-reported)	0.7	0.8	2.7	-0.0	-0.8	-1.6	-0.1
Medication: Lansoprazole	0.4	0.5	1.4	0.0	0.1	-1.2	-0.7
Prospective memory result	0.7	0.9	2.6	0.2	-0.9	-1.6	0.3
Lung cancer (father)	0.3	0.4	1.0	-1.0	0.5	-0.0	-0.5
Illnesses of mother	1.6	1.9	3.1	-1.6	1.3	0.5	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	-0.6	-1.0	0.5	-0.4
Pulse wave Arterial Stiffness index	1.0	1.1	1.7	1.1	-1.2	0.2	-1.3
Impedance of arm (left)	9.2	42.4	57.0	7.5	-6.6	-5.5	-6.2
Arm fat mass (right)	0.9	3.7	7.5	-2.7	2.3	0.6	1.3
Trunk predicted mass	0.7	4.1	9.1	-3.0	0.6	2.6	0.1
Standing height	4.1	40.9	66.9	5.0	-8.2	-2.8	-8.0
Length of working week for main job	2.1	2.3	4.7	-0.6	2.2	0.8	1.9
Exposure to tobacco smoke at home	0.3	0.4	1.0	-1.0	0.1	0.7	0.2
Breastfed as a baby	3.5	4.4	9.0	-1.9	1.5	3.0	1.7
Tense / ‘highly strung’	9.5	15.8	25.4	3.1	-3.9	-5.0	-3.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	7.1	0.6	-2.2	-2.7	-1.5
Hair/balding pattern: Pattern 4	0.5	1.1	4.0	-0.4	0.1	2.0	-0.7
Birth weight of first child	5.5	10.0	19.4	-4.4	2.9	2.1	2.9
Peak expiratory flow (PEF)	0.4	1.0	3.9	-0.5	-0.2	2.0	-0.0
Pulse wave reflection index	1.7	2.0	3.2	-1.7	0.8	1.8	1.2
Ever highly irritable/argumentative for 2 days	8.4	10.1	13.7	2.6	-3.3	-3.7	-3.0
Loud music exposure frequency	0.5	0.5	1.6	0.6	-0.0	-1.3	-0.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	3.2	-0.4	-0.4	-1.8	-0.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.2	1.3	-1.1	-0.4	-1.5
Blood clot in the leg (DVT)	0.4	0.6	1.6	-1.3	-0.0	-0.7	0.4
Medication: Paracetamol	1.6	2.7	7.3	-2.7	0.9	-0.7	1.5
Headache pain in last month	0.2	0.4	1.0	-0.2	-0.6	-1.0	-0.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.9	0.5	-1.3	-2.0	-0.1
Glaucoma (self-reported)	1.0	1.2	3.6	1.9	-0.1	-0.8	-0.7
Gout (self-reported)	0.6	0.9	1.8	1.0	-0.6	-0.6	-1.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.5	-0.3	0.7	-0.2	1.6
Medication: Amlodipine	0.9	1.2	3.2	-0.2	0.7	1.8	1.1
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.6	0.6	-1.9	-0.5	-1.8
Birth weight	2.3	5.0	6.7	-2.6	1.7	2.5	2.0
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.9	-0.4	-0.9	-0.1	-0.7
High blood pressure (siblings)	1.9	2.7	3.2	1.8	-1.8	-1.7	-1.2
Forced vital capacity (FVC), Best measure	0.1	0.4	0.7	-0.8	-0.6	0.9	0.1
Body fat percentage	0.2	0.8	2.0	0.5	0.1	-1.4	-1.0
Leg fat percentage (right)	0.1	0.5	1.2	0.6	0.3	-1.1	-0.6
Arm fat-free mass (right)	0.9	4.4	9.3	-3.0	1.1	2.6	0.2
Exposure to tobacco smoke outside home	1.2	1.6	3.6	-1.9	1.5	0.9	0.2
Comparative body size at age 10	10.2	28.2	43.8	-6.6	4.9	4.7	4.8
Number of full brothers	0.7	0.9	1.5	-1.2	0.5	-0.6	1.2
Worry too long after embarrassment	1.0	1.6	6.0	0.6	0.2	-2.4	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	9.3	0.3	-1.6	-3.0	-1.0
Wheeze or whistling in the chest in last year	2.9	5.1	9.0	1.8	-3.0	-2.1	-2.0
Number of children fathered	0.7	0.8	2.3	-0.3	-0.8	-0.2	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.1	-0.4	-0.6	-0.2
Age at first live birth	0.9	1.6	2.8	-1.4	1.7	0.0	1.4
Pulse wave peak to peak time	0.4	0.5	0.6	-0.7	0.8	-0.4	0.7
Health satisfaction	6.0	7.8	9.8	2.5	-3.1	-3.0	-2.5
Shortness of breath walking on level ground	1.0	1.2	2.7	0.5	-1.6	-1.1	-0.7
Qualifications: College or University degree	1.4	4.3	9.3	-0.9	3.0	-0.1	2.6
Eye problems/disorders: None of the above	1.9	2.1	6.3	-1.1	0.6	2.5	0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	1.1	-0.5	0.5	-0.5
Emphysema/chronic bronchitis	0.5	0.6	1.3	-0.7	0.3	1.2	0.5
Medication for pain relief, constipation, heartburn	1.2	2.0	5.1	2.3	-1.0	-0.3	-1.3
Neck or shoulder pain in last month	0.9	1.2	4.0	0.4	-0.8	-0.2	-2.0
Medication: Blood pressure	0.4	0.7	1.6	-0.6	0.9	1.3	0.0
Angina (self-reported)	0.6	0.8	2.0	-0.2	1.4	0.1	1.0
Migraine (self-reported)	0.6	0.8	2.0	0.3	-1.0	-0.5	-1.4
Medication: Ibuprofen	0.3	0.4	0.7	-0.5	-0.3	0.9	-0.7
Medication: Allopurinol	0.2	0.3	0.9	0.3	-0.3	-0.9	-0.4
Medication: Omeprazole	0.5	0.6	1.1	-0.1	-0.9	-1.0	-0.6
Medication: Seretide 50 evohaler	0.3	0.3	0.5	0.3	-0.4	-0.7	0.7
Mean time to correctly identify matches	4.3	8.2	15.8	-2.2	3.0	1.7	4.0
Heart disease (mother)	0.1	0.2	0.3	-0.2	0.5	0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.5	-0.4	0.7	-0.1
Whole body fat mass	0.1	0.4	0.9	-1.0	0.5	-0.2	-0.6
Leg fat mass (right)	0.2	0.6	1.3	-1.1	1.0	0.1	-0.1
Arm predicted mass (right)	0.7	3.7	9.4	-3.1	1.0	2.1	-0.0
Pulse rate, automated reading	2.6	8.5	11.9	3.5	-1.8	-3.0	-3.1
Alcohol intake frequency.	0.8	1.9	4.7	0.6	-1.2	-1.1	-2.2
Comparative height size at age 10	0.5	2.5	5.0	1.1	-2.2	-0.5	-1.9
Number of full sisters	0.9	1.0	1.7	1.3	-1.1	-0.4	-1.0
Suffer from ‘nerves’	1.5	2.3	8.3	0.3	-0.8	-2.9	0.3
Overall health rating	4.8	10.3	12.5	2.4	-3.3	-3.5	-3.5
Chest pain or discomfort	1.7	2.4	3.2	1.7	-1.8	-1.1	-1.5
Had major operations	0.6	0.7	2.2	-0.4	-0.6	-1.5	0.0
Age at last live birth	1.9	2.7	4.5	-1.5	2.0	0.7	2.1
Family relationship satisfaction	6.5	8.0	10.2	3.1	-3.2	-2.4	-2.5
Leg pain on walking	2.8	3.5	7.1	1.3	-2.7	0.1	-2.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.3	0.8	-1.5	-1.3	-0.7
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.3	0.1	-0.7	0.5	-1.8
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.0	-0.4	-0.4	0.3
Medication: Aspirin	0.8	1.0	2.5	-0.1	1.0	1.6	0.7
Supplements: Vitamin C	0.3	0.4	0.5	0.6	-0.7	-0.1	-0.7
Knee pain experienced in last month	0.5	0.8	2.4	-0.1	-1.6	0.0	-0.9
Hypertension (Self-reported)	0.1	0.4	1.2	0.5	0.3	1.1	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	4.1	1.5	-2.0	-1.3	-1.8
Illnesses of father: Heart disease	0.1	0.2	0.5	0.4	-0.0	0.7	0.1
Illnesses of siblings: Diabetes	3.8	4.6	7.6	1.9	-2.2	-2.8	-1.6
Smoking status: Previous	2.1	3.1	11.3	-0.8	0.5	3.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted	5.8	12.2	21.5	2.3	-4.6	-2.3	-4.1
Whole body fat-free mass	1.0	5.7	13.4	-3.7	1.3	2.7	0.6
Leg fat-free mass (right)	2.0	10.6	23.1	-4.8	2.6	3.1	1.7
Arm fat percentage (left)	0.8	3.1	6.1	-2.1	2.5	-0.1	1.4
Average weekly red wine intake	2.2	3.2	6.1	-1.5	1.7	2.5	1.2
Handedness (chirality/laterality): Left-handed	1.2	1.5	3.8	-1.2	1.9	0.2	0.8
Mood swings	3.0	5.5	14.0	0.6	-1.6	-3.7	-2.2
Loneliness, isolation	2.6	3.6	5.1	1.4	-2.1	-1.6	-2.3
Long-standing illness, disability or infirmity	0.1	0.2	0.3	-0.5	-0.4	-0.6	0.0
Ever had bowel cancer screening	0.8	0.9	2.0	1.4	-0.6	1.1	-0.2
Diabetes diagnosed by doctor	0.0	0.1	0.2	0.2	0.0	-0.2	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.0	-0.3	1.0	0.2	-0.4
Friendships satisfaction	6.0	7.4	10.5	3.2	-2.3	-3.0	-2.3
Qualifications: nursing, teaching	1.6	2.5	5.3	-1.3	2.3	0.6	1.6
Commuting to job workplace: Walk	3.2	3.5	10.1	-0.4	1.8	0.6	3.2
Eye problems/disorders: Cataract	0.3	0.4	0.7	-0.8	0.9	-0.2	0.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.9	1.3	-1.7	-0.4	-1.2
Medication for cholesterol	0.7	1.1	2.0	-1.2	1.4	-0.2	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	1.9	1.4	-1.1	-1.2	-1.3
Back pain experienced in last month	2.5	3.6	6.0	2.3	-2.4	-0.8	-1.5
Mineral and other dietary supplements	0.5	0.7	1.0	-0.8	0.4	-0.9	1.0
Breast cancer (self-reported)	1.5	1.7	3.4	-1.6	0.1	1.8	0.9
Asthma (self-reported)	1.8	3.6	9.7	0.7	-3.1	-1.8	-1.0
Osteoporosis (self-reported)	1.1	1.3	2.7	-1.3	0.8	0.5	1.6
Osteoarthritis (self-reported)	0.5	0.7	1.6	-0.4	-0.3	-1.3	-0.8
Medication: Aspirin	0.6	0.8	2.3	-0.1	0.8	1.5	0.6
Medication: Gliclazide	1.4	1.5	2.7	1.5	-0.5	-1.6	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	0.8	-0.9	0.8	-0.2	0.8
Smoking status: Current	0.4	0.7	1.1	-1.1	0.7	0.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.1	6.2	-2.5	2.0	1.3	2.1
Whole body water mass	1.1	6.0	14.5	-3.8	1.4	2.7	0.7
Leg predicted mass (right)	2.1	11.2	23.7	-4.9	2.7	3.2	1.8
Arm fat mass (left)	1.0	4.0	8.2	-2.9	2.4	0.6	1.2
Number of self-reported non-cancer illnesses	3.2	5.5	7.6	1.8	-2.6	-2.8	-2.1
Average weekly champagne plus white wine intake	0.3	0.4	0.7	0.8	-0.4	-0.2	0.7
Miserableness	2.8	4.8	13.2	0.5	-1.2	-3.6	-2.1
Guilty feelings	0.4	0.7	1.7	0.2	-0.8	-1.3	-0.6
Wears glasses or contact lenses	0.1	0.2	0.3	-0.1	-0.5	0.2	-0.6
Ever taken oral contraceptive pill	0.4	0.4	1.0	0.7	-0.3	1.0	-0.3
Hearing aid user	0.1	0.1	0.4	0.2	-0.6	-0.2	0.1
Mother’s age at death	0.4	0.5	1.5	0.1	-0.5	-1.2	0.4
Financial situation satisfaction	3.3	4.1	8.4	1.7	-1.9	-1.2	-2.9
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	-0.2	0.1	0.4	0.9
Commuting to job workplace: Public transport	4.9	5.9	9.5	-2.2	2.9	0.8	3.1
Eye problems/disorders: Glaucoma	1.6	1.9	3.7	1.7	-0.6	-1.9	-0.6
Medication: Blood pressure	0.6	1.1	3.0	1.7	-1.1	0.2	-0.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.5	0.3	-1.1	0.7	-1.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.5	0.7	-0.2	1.6	-1.1
High cholesterol (Self-reported)	2.7	4.9	8.6	-0.8	2.9	2.9	1.4
Medication: Bendroflumethiazide	0.5	0.7	1.5	1.0	0.5	1.2	0.2
Medication: Paracetamol	1.4	2.2	5.4	-2.3	0.5	-1.0	1.5
Medication: Lisinopril	0.2	0.2	0.6	0.8	-0.3	-0.1	-0.3
Medication: Atorvastatin	1.9	2.3	3.4	-1.8	1.7	1.6	0.7
Illnesses of father: High blood pressure	3.4	4.3	8.6	1.6	-2.2	-1.1	-2.9
Alcohol drinker status: Never	0.2	0.2	0.4	-0.6	0.5	-0.1	0.5
Ever smoked	0.5	0.9	3.0	-0.3	-0.5	1.7	0.4
Basal metabolic rate	0.8	4.2	11.0	-3.3	1.1	2.1	0.3
Leg fat percentage (left)	0.1	0.4	0.7	-0.1	0.9	-0.8	-0.1
Arm fat-free mass (left)	0.7	3.5	9.1	-3.0	0.9	2.0	0.2
Number of operations (self-reported)	0.7	1.0	2.2	-0.4	-1.5	-1.3	0.1
Average weekly beer plus cider intake	1.1	1.6	2.9	-1.1	-1.0	-1.1	-1.7
Irritability	0.5	0.8	2.5	0.7	-0.6	-1.6	-0.3
Risk taking	1.6	2.4	5.6	1.1	-2.4	0.1	-1.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.0	0.6	-1.4	-1.4	-0.7
Fractured/broken bones in last 5 years	1.1	1.4	3.4	-1.0	0.8	0.8	1.8
Age started oral contraceptive pill	1.8	2.2	3.7	-1.1	1.9	0.5	1.9
Diastolic blood pressure, automated reading	1.2	3.6	6.4	2.0	-2.0	-0.4	-2.5
Ever depressed for a whole week	4.3	5.3	7.2	1.7	-2.7	-2.5	-2.2
Unable to work because of sickness or disability	1.2	1.6	3.3	-1.0	1.1	-0.9	1.8
Commuting to job workplace: Cycle	1.2	1.4	3.7	-1.9	1.2	0.0	0.8
Myopia	0.1	0.1	0.2	0.1	-0.3	-0.5	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.5	-0.6	-0.3	-1.2	0.5
Cholesterol lowering medication	0.8	1.2	1.8	-1.0	1.3	0.6	1.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.9	-0.3	-0.1	-1.0	-0.3
Pain experienced in last month	0.9	1.5	2.6	-0.7	1.6	0.1	1.6
Supplements: Calcium	0.6	0.7	1.6	1.3	-1.0	0.3	0.2
Basal cell carcinoma (self-reported)	0.5	0.6	2.0	0.0	0.5	1.4	0.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.4	-0.9	1.2	1.1	0.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.2	-1.5	0.1	-0.8	0.8
Heart disease (siblings)	0.4	0.5	0.7	0.8	0.4	-0.9	0.8
Alcohol drinker status: Previous	9.0	10.3	14.7	-3.4	3.8	2.2	3.2
Pack years of smoking	6.3	9.2	13.4	-2.1	2.9	3.2	3.7
Impedance of whole body	15.4	78.3	106.1	10.3	-9.0	-7.3	-8.6
Leg fat mass (left)	0.3	1.1	2.5	-1.6	1.3	0.3	0.1
Arm predicted mass (left)	0.8	3.8	10.1	-3.2	1.0	2.0	0.2