Hub : Genes

CACNA2D2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Spleen 0.1760 0.0730 5.3e-04 0.014 NA 0.031 NA 0.017 1.4e-01 NA 5.4e-02 NA 1.2e-01
2 GTEx Testis 0.0760 0.0390 9.8e-04 0.059 NA 0.041 NA 0.046 1.3e-03 NA 6.2e-03 NA 4.1e-03
3 ROSMAP Brain Pre-frontal Cortex 0.0501 0.0286 3.5e-03 0.016 0.011 0.014 0.015 0.016 3.4e-03 1.1e-02 6.0e-03 0.0045 3.6e-03
4 TCGA Prostate Adenocarcinoma 0.0421 0.0216 3.2e-05 0.066 0.040 0.043 NA 0.062 2.1e-07 5.1e-05 2.3e-05 NA 4.6e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.1 1.8 2.7 -0.8 -1.6 -1.1 -1.6
Bipolar Disorder or Schizophrenia 0.7 1.8 3.6 -0.8 -1.9 -0.9 -1.4
Depressed Affect (Nagel 2018) 2.2 4.7 8.9 0.8 -1.8 -3.0 -2.4
Depression (Nagel 2018) 7.9 11.9 20.5 2.3 -3.4 -4.5 -3.2
Intelligence (Savage-Jansen 2018) 1.0 3.0 8.2 -1.2 2.9 0.8 1.3
Neuroticism (Nagel 2018) 6.0 14.1 29.7 2.8 -3.2 -5.5 -2.9
Schizophrenia (2018) 0.2 0.5 1.4 -0.4 -1.2 -0.3 -0.4
Schizophrenia vs Biploar Disorder 1.1 1.4 2.8 -0.9 1.7 1.2 0.7
Worry (Nagel 2018) 9.5 20.1 41.2 3.4 -4.1 -6.4 -3.3
Alzheimer’s Disease (in mother) 0.1 0.1 0.5 -0.7 -0.2 0.1 -0.0
Alzheimer’s Disease (in father) 0.6 0.6 2.1 -1.5 0.2 -0.1 -0.6
Alzheimer’s Disease (including proxy) 0.3 0.5 1.7 -1.3 -0.0 0.1 -0.5
Crohns Disease (2017) 1.1 2.4 5.1 -1.2 1.8 2.2 0.0
Irritable Bowel Disease (IBD) 0.6 1.5 3.2 -0.9 1.5 1.8 0.0
Ulcerative Colitis (UC) 0.4 0.7 1.0 -0.5 1.0 0.9 0.8
Major Depression (MDD) 2.0 2.4 5.3 2.3 -1.6 -1.3 0.0
Reaction Time 2.9 5.6 11.3 -1.8 2.7 0.8 3.4
Verbal and Numeric Reasoning (VNR) 2.3 5.6 10.4 -2.3 3.2 1.8 1.9
Breast Cancer 3.0 7.1 13.3 -2.2 3.6 2.4 2.1
Ovarian Cancer 0.5 0.7 2.0 0.0 0.9 0.3 1.4
Prostate Cancer 2.0 2.8 4.5 1.2 -2.1 -1.8 -1.4
Age at First Birth 0.2 0.3 1.1 1.1 -0.2 -0.3 -0.2
Bipolar Disorder (2011) 0.0 0.0 0.1 0.0 0.0 0.3 0.0
Body Mass Index (BMI) (2010) 3.5 4.8 9.7 -3.1 2.2 1.1 1.9
Coronary Artery Disease (CAD) 0.2 0.3 0.7 -0.3 0.5 0.8 0.2
Crohns Disease (2012) 1.4 2.3 3.2 -1.7 1.8 1.6 0.7
Mean Putamen Volume 3.5 4.0 6.2 1.6 -2.4 -2.5 -1.1
Fasting Glucose 0.4 0.4 1.0 -0.3 1.0 -0.4 0.7
HbA1C 0.4 0.4 1.1 -0.5 0.5 1.0 0.4
HDL Cholesterol 0.9 1.5 2.5 -0.1 1.6 1.2 1.5
LDL Cholesterol 0.5 0.8 2.3 0.4 0.0 1.5 -0.8
Lupus 1.9 2.9 5.2 0.3 -2.3 1.1 -2.2
Neuroticism (2016) 4.7 6.7 13.6 2.3 -1.6 -3.7 -2.4
Primary Biliary Cirrhosis 0.3 0.4 1.1 -0.7 1.1 -0.1 0.3
Rheumatoid Arthritis 0.5 0.7 1.3 -0.8 1.1 -0.6 0.7
Schizophrenia (2014) 0.2 0.5 1.1 -0.7 -1.0 -0.3 -0.4
Triglycerides 1.4 2.3 3.4 1.6 -1.5 0.9 -1.9
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.7 0.5 -0.1 0.7 -0.8
Ulcerative Colitis 1.7 2.5 4.3 -1.3 2.1 1.2 1.6
Blood Eosinophil Count 4.6 35.2 80.8 4.9 -9.0 -2.2 -5.6
Blood Platelet Count 2.0 23.3 34.9 -4.4 4.9 5.9 3.9
Blood Red Count 2.1 20.7 31.9 5.7 -4.1 -3.6 -4.6
Blood White Count 0.3 2.1 3.4 1.9 -1.5 0.3 -1.6
Heel T-Score 0.8 6.3 10.6 3.3 -1.5 -1.5 -3.2
BMI 5.0 28.8 49.1 -7.0 5.9 3.1 4.7
Height 5.1 98.6 158.8 7.7 -12.6 -4.5 -12.5
Waist Hip Ratio (WHR) 5.6 25.4 33.4 4.1 -5.6 -5.8 -4.4
Systolic Blood Pressure 2.2 11.1 17.1 3.6 -3.7 0.0 -4.1
Smoking Status 1.8 4.3 8.8 -2.0 1.4 3.0 1.5
Allergy or Eczema 2.3 6.1 13.1 2.0 -3.6 -1.8 -1.9
Cardiovascular Disease 0.4 1.3 2.9 1.3 -0.5 0.5 -1.7
Hypothyroidism (self reported) 0.1 0.3 0.7 0.9 -0.2 -0.5 0.2
Respiratory disease 1.2 2.8 7.7 0.8 -2.8 -1.6 -0.5
Type 2 Diabetes (T2D) (2018) 0.8 1.4 3.9 0.5 -1.0 -0.7 -2.0
Lung FEV1/FVC ratio 0.9 4.5 8.2 0.3 -2.7 -1.6 -2.9
Lung FVC 5.1 26.0 35.5 -4.8 5.1 4.3 6.0
Neuroticism 4.9 11.9 24.9 2.3 -2.8 -5.0 -3.1
Chronotype (morning person) 11.6 26.8 39.9 -4.3 6.3 5.2 4.6
Hair Pigment 0.0 0.7 1.8 -0.7 0.7 1.3 0.5
Tanning 0.0 0.5 1.3 0.6 -0.4 1.1 -0.3
Hand grip strength (left) 0.7 1.9 4.8 -0.4 0.2 2.2 -1.5
Number of treatments/medications taken 0.8 1.5 2.7 0.2 -1.6 -1.6 -0.8
Average weekly spirits intake 2.3 2.8 4.6 1.3 -1.9 -2.1 -1.1
Sensitivity / hurt feelings 2.6 4.4 8.0 1.5 -1.7 -2.8 -2.1
Frequency of depressed mood in last 2 weeks 7.0 9.7 24.2 1.2 -2.9 -4.9 -2.2
Hearing difficulty/problems: Yes 0.3 0.4 0.6 -0.7 0.5 -0.8 0.6
Relative age of first facial hair 8.1 16.7 25.7 3.4 -5.1 -2.2 -5.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.7 -0.2 -0.0 -1.3 0.5
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.6 -0.8 -0.6 0.5 0.1
Ever had hysterectomy (womb removed) 0.4 0.5 0.8 0.4 -0.8 -0.5 -0.9
Systolic blood pressure, automated reading 0.4 1.2 3.0 0.7 -0.6 1.7 -0.9
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 4.1 -0.2 0.8 -2.0 0.8
Angina 0.3 0.3 0.8 -0.1 0.9 -0.4 0.6
Medication for hormone replacement therapy 1.4 1.6 3.1 0.3 -1.8 0.6 -1.6
Vitamin and mineral supplements 2.3 3.2 8.0 -0.9 2.8 1.4 1.5
Supplements: Zinc 0.3 0.3 0.5 -0.7 0.1 0.5 0.7
Medication: Co-codamol 0.1 0.1 0.3 -0.6 0.4 -0.0 0.1
Medication: Metformin 0.2 0.3 0.5 0.0 0.7 0.7 -0.5
Diabetes (father) 0.5 0.7 1.7 0.3 -0.8 -1.3 -0.5
Diabetes (mother) 2.0 2.6 4.9 2.2 -1.8 -0.8 -1.3
Severe depression (siblings) 4.8 5.4 8.4 1.6 -2.4 -2.9 -2.2
Pack years adult smoking proportion 5.2 7.9 12.1 -1.8 2.8 2.9 3.5
Impedance of leg (right) 19.9 96.4 132.2 11.5 -10.0 -8.1 -9.4
Leg fat-free mass (left) 1.6 8.6 18.9 -4.3 2.3 2.8 1.5
Trunk fat percentage 0.4 1.7 3.2 0.9 -0.5 -1.8 -1.6
Hand grip strength (right) 1.0 2.6 6.2 -0.1 -0.7 2.0 -2.5
Townsend deprivation index at recruitment 0.4 0.6 1.4 0.8 0.5 1.2 0.5
Current tobacco smoking 0.6 1.0 1.5 -1.1 0.9 0.8 1.2
Average weekly fortified wine intake 0.4 0.5 1.0 0.8 -1.0 0.3 -0.1
Maternal smoking around birth 4.0 5.8 11.1 -3.3 1.9 2.6 1.3
Fed-up feelings 1.8 3.3 5.9 0.6 -1.4 -2.4 -2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 7.3 9.7 15.8 2.4 -2.9 -4.0 -2.9
Relative age voice broke 4.2 6.4 11.6 2.1 -3.0 -0.7 -3.4
Taking other prescription medications 5.8 9.0 14.4 1.9 -3.8 -2.9 -3.1
Age when periods started (menarche) 6.5 15.6 30.4 2.3 -5.1 -0.4 -5.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.6 -0.8 -0.4 -0.3 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.4 5.7 1.8 -1.7 -1.1 -2.4
Tinnitus: Yes, but not now, but have in the past 3.4 3.6 6.4 0.7 -1.8 -2.5 -2.1
Qualifications: CSEs or equivalent 2.4 3.1 5.4 1.6 -2.1 -0.4 -2.3
Serious illness, injury or assault to yourself 0.1 0.2 0.4 -0.5 0.1 -0.1 0.6
High blood pressure 0.3 0.8 2.0 0.9 -0.1 1.4 -0.5
Hayfever, allergic rhinitis or eczema 4.5 9.8 16.5 2.3 -4.1 -3.1 -2.7
Multivitamins +/- minerals 1.8 2.2 7.0 0.7 -2.6 -0.5 -1.1
Stomach or abdominal pain in last month 4.5 5.6 8.0 2.8 -2.1 -2.7 -1.7
Supplements: Glucosamine 0.6 0.8 1.5 0.7 -1.1 0.3 -1.2
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.8 0.6 -0.3 -1.3 -0.2
Medication: Atenolol 0.6 0.7 1.8 1.4 -0.9 0.0 -0.6
Medication: Levothyroxine sodium 0.1 0.2 0.4 -0.3 0.1 -0.6 0.4
Sitting height 0.7 5.0 8.7 1.1 -2.9 1.2 -3.0
Chronic bronchitis/emphysema (father) 1.0 1.2 2.4 0.6 -1.0 -1.5 -1.0
High blood pressure (mother) 0.2 0.3 1.3 1.1 -0.3 -0.2 0.1
Body mass index (BMI) 4.6 19.5 28.4 -5.3 5.1 2.8 4.0
Impedance of leg (left) 18.8 91.4 123.2 11.1 -9.6 -7.9 -9.3
Leg predicted mass (left) 1.6 8.7 18.9 -4.3 2.3 2.9 1.4
Trunk fat mass 0.1 0.6 1.7 -0.2 -0.3 -0.8 -1.3
Waist circumference 0.4 1.3 3.3 -1.8 1.2 0.2 0.5
Number of incorrect matches in round 3.1 5.2 7.1 -1.8 2.1 2.4 2.7
Past tobacco smoking 1.3 2.4 7.9 1.1 -0.2 -2.8 -0.6
Alcohol usually taken with meals 0.3 0.5 0.8 0.8 -0.9 -0.3 -0.8
Nervous feelings 7.7 14.4 27.8 2.7 -3.7 -5.3 -3.1
Frequency of tenseness / restlessness in last 2 weeks 4.1 6.4 12.2 0.9 -2.4 -3.5 -2.6
Hearing difficulty/problems with background noise 0.4 0.6 1.2 -0.2 0.9 1.1 0.7
Hair/balding pattern: Pattern 2 0.5 0.7 2.0 0.2 -0.8 -1.4 -0.1
Had menopause 6.3 7.9 10.5 -3.2 2.7 1.8 3.2
Had other major operations 0.6 0.8 1.6 -0.3 -1.3 -1.2 -0.2
Forced vital capacity (FVC) 0.1 0.2 0.5 -0.3 -0.7 0.4 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 2.2 5.0 5.8 2.2 -2.2 -2.1 -2.4
Ever unenthusiastic/disinterested for a whole week 6.5 8.0 15.1 1.4 -2.7 -3.9 -2.8
Qualifications: None of the above 0.2 0.5 0.9 0.3 -1.0 0.4 -0.9
Financial difficulties in last 2 years 1.6 2.2 3.6 1.9 -1.1 -1.7 -1.1
Mouth/teeth dental problems 0.6 0.9 1.5 -1.0 1.2 -0.3 0.9
Heart attack 0.6 0.8 1.3 -0.9 1.1 1.1 -0.1
Allergy 4.2 9.8 20.7 -1.5 4.6 3.1 2.5
Pain all over the body in last month 0.4 0.4 0.8 -0.9 0.5 -0.4 0.6
Diabetes (self-reported) 0.0 0.0 0.1 -0.0 0.0 -0.2 -0.4
Hayfever/allergic rhinitis (self-reported) 4.2 5.5 8.7 1.9 -2.5 -1.8 -2.9
Medication: Ramipril 0.6 0.8 1.6 -0.7 0.8 0.6 1.3
Medication: Simvastatin 2.0 3.0 5.6 -0.7 1.9 2.4 1.5
Fluid intelligence score 0.5 1.1 2.6 -0.8 1.6 0.9 0.2
Illnesses of siblings 2.9 4.0 7.7 -2.4 1.5 2.8 0.6
Neuroticism score 7.5 15.7 33.4 2.4 -3.2 -5.8 -3.6
Weight 0.5 2.4 6.8 -2.6 1.0 1.3 0.1
Impedance of arm (right) 10.6 49.3 64.8 8.1 -7.2 -6.2 -6.6
Arm fat percentage (right) 0.8 3.0 5.4 -2.1 2.3 -0.3 1.5
Trunk fat-free mass 0.7 4.1 9.3 -3.1 0.5 2.6 0.0
Hip circumference 1.7 7.1 10.5 -3.2 3.0 2.3 1.9
Time employed in main current job 7.1 8.2 15.3 -3.2 3.9 1.3 2.2
Alcohol intake versus 10 years previously 3.1 4.6 7.1 1.2 -2.3 -2.2 -2.7
Father’s age at death 0.7 1.0 2.1 -0.9 0.8 1.5 0.4
Worrier / anxious feelings 5.6 10.6 27.7 2.0 -2.2 -5.3 -2.4
Frequency of tiredness / lethargy in last 2 weeks 3.8 6.2 8.1 2.5 -2.2 -2.8 -2.4
Falls in the last year 1.7 2.3 4.2 -1.6 1.2 1.1 2.0
Hair/balding pattern: Pattern 3 0.3 0.4 1.1 1.0 0.3 0.7 0.2
Number of live births 0.8 1.2 3.9 -2.0 0.4 0.8 -0.4
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 3.0 0.2 -1.7 -0.6 -0.9
Pulse rate 1.4 2.4 5.4 1.6 -0.6 -2.3 -1.1
Happiness 3.0 3.7 5.4 1.6 -1.6 -2.3 -2.0
Noisy workplace 0.4 0.4 1.3 -0.6 -0.3 -1.1 0.0
Qualifications: A levels/AS levels or equivalent 1.0 2.3 4.2 -0.8 2.1 0.6 2.0
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 4.4 -1.4 1.4 2.1 0.5
Mouth/teeth dental problems: Dentures 0.5 0.9 1.9 -1.4 0.5 1.0 0.6
Asthma 2.0 3.8 10.0 0.9 -3.2 -1.9 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.4 -0.6 -0.1 0.7 -0.3
Medication: Cholesterol lowering 1.3 2.0 5.2 -0.7 1.5 2.3 0.1
Depression (self-reported) 0.7 0.8 2.7 -0.0 -0.8 -1.6 -0.1
Medication: Lansoprazole 0.4 0.5 1.4 0.0 0.1 -1.2 -0.7
Prospective memory result 0.7 0.9 2.6 0.2 -0.9 -1.6 0.3
Lung cancer (father) 0.3 0.4 1.0 -1.0 0.5 -0.0 -0.5
Illnesses of mother 1.6 1.9 3.1 -1.6 1.3 0.5 1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.0 -0.6 -1.0 0.5 -0.4
Pulse wave Arterial Stiffness index 1.0 1.1 1.7 1.1 -1.2 0.2 -1.3
Impedance of arm (left) 9.2 42.4 57.0 7.5 -6.6 -5.5 -6.2
Arm fat mass (right) 0.9 3.7 7.5 -2.7 2.3 0.6 1.3
Trunk predicted mass 0.7 4.1 9.1 -3.0 0.6 2.6 0.1
Standing height 4.1 40.9 66.9 5.0 -8.2 -2.8 -8.0
Length of working week for main job 2.1 2.3 4.7 -0.6 2.2 0.8 1.9
Exposure to tobacco smoke at home 0.3 0.4 1.0 -1.0 0.1 0.7 0.2
Breastfed as a baby 3.5 4.4 9.0 -1.9 1.5 3.0 1.7
Tense / ‘highly strung’ 9.5 15.8 25.4 3.1 -3.9 -5.0 -3.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 7.1 0.6 -2.2 -2.7 -1.5
Hair/balding pattern: Pattern 4 0.5 1.1 4.0 -0.4 0.1 2.0 -0.7
Birth weight of first child 5.5 10.0 19.4 -4.4 2.9 2.1 2.9
Peak expiratory flow (PEF) 0.4 1.0 3.9 -0.5 -0.2 2.0 -0.0
Pulse wave reflection index 1.7 2.0 3.2 -1.7 0.8 1.8 1.2
Ever highly irritable/argumentative for 2 days 8.4 10.1 13.7 2.6 -3.3 -3.7 -3.0
Loud music exposure frequency 0.5 0.5 1.6 0.6 -0.0 -1.3 -0.1
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 3.2 -0.4 -0.4 -1.8 -0.2
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.2 1.3 -1.1 -0.4 -1.5
Blood clot in the leg (DVT) 0.4 0.6 1.6 -1.3 -0.0 -0.7 0.4
Medication: Paracetamol 1.6 2.7 7.3 -2.7 0.9 -0.7 1.5
Headache pain in last month 0.2 0.4 1.0 -0.2 -0.6 -1.0 -0.4
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 3.9 0.5 -1.3 -2.0 -0.1
Glaucoma (self-reported) 1.0 1.2 3.6 1.9 -0.1 -0.8 -0.7
Gout (self-reported) 0.6 0.9 1.8 1.0 -0.6 -0.6 -1.4
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.5 -0.3 0.7 -0.2 1.6
Medication: Amlodipine 0.9 1.2 3.2 -0.2 0.7 1.8 1.1
Medication: Ventolin 100micrograms inhaler 1.5 1.9 3.6 0.6 -1.9 -0.5 -1.8
Birth weight 2.3 5.0 6.7 -2.6 1.7 2.5 2.0
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.9 -0.4 -0.9 -0.1 -0.7
High blood pressure (siblings) 1.9 2.7 3.2 1.8 -1.8 -1.7 -1.2
Forced vital capacity (FVC), Best measure 0.1 0.4 0.7 -0.8 -0.6 0.9 0.1
Body fat percentage 0.2 0.8 2.0 0.5 0.1 -1.4 -1.0
Leg fat percentage (right) 0.1 0.5 1.2 0.6 0.3 -1.1 -0.6
Arm fat-free mass (right) 0.9 4.4 9.3 -3.0 1.1 2.6 0.2
Exposure to tobacco smoke outside home 1.2 1.6 3.6 -1.9 1.5 0.9 0.2
Comparative body size at age 10 10.2 28.2 43.8 -6.6 4.9 4.7 4.8
Number of full brothers 0.7 0.9 1.5 -1.2 0.5 -0.6 1.2
Worry too long after embarrassment 1.0 1.6 6.0 0.6 0.2 -2.4 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.5 3.2 9.3 0.3 -1.6 -3.0 -1.0
Wheeze or whistling in the chest in last year 2.9 5.1 9.0 1.8 -3.0 -2.1 -2.0
Number of children fathered 0.7 0.8 2.3 -0.3 -0.8 -0.2 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.4 -0.1 -0.4 -0.6 -0.2
Age at first live birth 0.9 1.6 2.8 -1.4 1.7 0.0 1.4
Pulse wave peak to peak time 0.4 0.5 0.6 -0.7 0.8 -0.4 0.7
Health satisfaction 6.0 7.8 9.8 2.5 -3.1 -3.0 -2.5
Shortness of breath walking on level ground 1.0 1.2 2.7 0.5 -1.6 -1.1 -0.7
Qualifications: College or University degree 1.4 4.3 9.3 -0.9 3.0 -0.1 2.6
Eye problems/disorders: None of the above 1.9 2.1 6.3 -1.1 0.6 2.5 0.9
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.2 1.1 -0.5 0.5 -0.5
Emphysema/chronic bronchitis 0.5 0.6 1.3 -0.7 0.3 1.2 0.5
Medication for pain relief, constipation, heartburn 1.2 2.0 5.1 2.3 -1.0 -0.3 -1.3
Neck or shoulder pain in last month 0.9 1.2 4.0 0.4 -0.8 -0.2 -2.0
Medication: Blood pressure 0.4 0.7 1.6 -0.6 0.9 1.3 0.0
Angina (self-reported) 0.6 0.8 2.0 -0.2 1.4 0.1 1.0
Migraine (self-reported) 0.6 0.8 2.0 0.3 -1.0 -0.5 -1.4
Medication: Ibuprofen 0.3 0.4 0.7 -0.5 -0.3 0.9 -0.7
Medication: Allopurinol 0.2 0.3 0.9 0.3 -0.3 -0.9 -0.4
Medication: Omeprazole 0.5 0.6 1.1 -0.1 -0.9 -1.0 -0.6
Medication: Seretide 50 evohaler 0.3 0.3 0.5 0.3 -0.4 -0.7 0.7
Mean time to correctly identify matches 4.3 8.2 15.8 -2.2 3.0 1.7 4.0
Heart disease (mother) 0.1 0.2 0.3 -0.2 0.5 0.6 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.5 0.5 -0.4 0.7 -0.1
Whole body fat mass 0.1 0.4 0.9 -1.0 0.5 -0.2 -0.6
Leg fat mass (right) 0.2 0.6 1.3 -1.1 1.0 0.1 -0.1
Arm predicted mass (right) 0.7 3.7 9.4 -3.1 1.0 2.1 -0.0
Pulse rate, automated reading 2.6 8.5 11.9 3.5 -1.8 -3.0 -3.1
Alcohol intake frequency. 0.8 1.9 4.7 0.6 -1.2 -1.1 -2.2
Comparative height size at age 10 0.5 2.5 5.0 1.1 -2.2 -0.5 -1.9
Number of full sisters 0.9 1.0 1.7 1.3 -1.1 -0.4 -1.0
Suffer from ‘nerves’ 1.5 2.3 8.3 0.3 -0.8 -2.9 0.3
Overall health rating 4.8 10.3 12.5 2.4 -3.3 -3.5 -3.5
Chest pain or discomfort 1.7 2.4 3.2 1.7 -1.8 -1.1 -1.5
Had major operations 0.6 0.7 2.2 -0.4 -0.6 -1.5 0.0
Age at last live birth 1.9 2.7 4.5 -1.5 2.0 0.7 2.1
Family relationship satisfaction 6.5 8.0 10.2 3.1 -3.2 -2.4 -2.5
Leg pain on walking 2.8 3.5 7.1 1.3 -2.7 0.1 -2.3
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.3 0.8 -1.5 -1.3 -0.7
Commuting to job workplace: Car/motor vehicle 0.9 1.0 3.3 0.1 -0.7 0.5 -1.8
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 -0.0 -0.4 -0.4 0.3
Medication: Aspirin 0.8 1.0 2.5 -0.1 1.0 1.6 0.7
Supplements: Vitamin C 0.3 0.4 0.5 0.6 -0.7 -0.1 -0.7
Knee pain experienced in last month 0.5 0.8 2.4 -0.1 -1.6 0.0 -0.9
Hypertension (Self-reported) 0.1 0.4 1.2 0.5 0.3 1.1 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 2.9 4.1 1.5 -2.0 -1.3 -1.8
Illnesses of father: Heart disease 0.1 0.2 0.5 0.4 -0.0 0.7 0.1
Illnesses of siblings: Diabetes 3.8 4.6 7.6 1.9 -2.2 -2.8 -1.6
Smoking status: Previous 2.1 3.1 11.3 -0.8 0.5 3.4 0.3
Forced expiratory volume in 1-second (FEV1), predicted 5.8 12.2 21.5 2.3 -4.6 -2.3 -4.1
Whole body fat-free mass 1.0 5.7 13.4 -3.7 1.3 2.7 0.6
Leg fat-free mass (right) 2.0 10.6 23.1 -4.8 2.6 3.1 1.7
Arm fat percentage (left) 0.8 3.1 6.1 -2.1 2.5 -0.1 1.4
Average weekly red wine intake 2.2 3.2 6.1 -1.5 1.7 2.5 1.2
Handedness (chirality/laterality): Left-handed 1.2 1.5 3.8 -1.2 1.9 0.2 0.8
Mood swings 3.0 5.5 14.0 0.6 -1.6 -3.7 -2.2
Loneliness, isolation 2.6 3.6 5.1 1.4 -2.1 -1.6 -2.3
Long-standing illness, disability or infirmity 0.1 0.2 0.3 -0.5 -0.4 -0.6 0.0
Ever had bowel cancer screening 0.8 0.9 2.0 1.4 -0.6 1.1 -0.2
Diabetes diagnosed by doctor 0.0 0.1 0.2 0.2 0.0 -0.2 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.0 -0.3 1.0 0.2 -0.4
Friendships satisfaction 6.0 7.4 10.5 3.2 -2.3 -3.0 -2.3
Qualifications: nursing, teaching 1.6 2.5 5.3 -1.3 2.3 0.6 1.6
Commuting to job workplace: Walk 3.2 3.5 10.1 -0.4 1.8 0.6 3.2
Eye problems/disorders: Cataract 0.3 0.4 0.7 -0.8 0.9 -0.2 0.3
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 2.9 1.3 -1.7 -0.4 -1.2
Medication for cholesterol 0.7 1.1 2.0 -1.2 1.4 -0.2 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 1.9 1.4 -1.1 -1.2 -1.3
Back pain experienced in last month 2.5 3.6 6.0 2.3 -2.4 -0.8 -1.5
Mineral and other dietary supplements 0.5 0.7 1.0 -0.8 0.4 -0.9 1.0
Breast cancer (self-reported) 1.5 1.7 3.4 -1.6 0.1 1.8 0.9
Asthma (self-reported) 1.8 3.6 9.7 0.7 -3.1 -1.8 -1.0
Osteoporosis (self-reported) 1.1 1.3 2.7 -1.3 0.8 0.5 1.6
Osteoarthritis (self-reported) 0.5 0.7 1.6 -0.4 -0.3 -1.3 -0.8
Medication: Aspirin 0.6 0.8 2.3 -0.1 0.8 1.5 0.6
Medication: Gliclazide 1.4 1.5 2.7 1.5 -0.5 -1.6 -0.9
Illnesses of father: None of the above (group 1) 0.4 0.5 0.8 -0.9 0.8 -0.2 0.8
Smoking status: Current 0.4 0.7 1.1 -1.1 0.7 0.3 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.1 6.2 -2.5 2.0 1.3 2.1
Whole body water mass 1.1 6.0 14.5 -3.8 1.4 2.7 0.7
Leg predicted mass (right) 2.1 11.2 23.7 -4.9 2.7 3.2 1.8
Arm fat mass (left) 1.0 4.0 8.2 -2.9 2.4 0.6 1.2
Number of self-reported non-cancer illnesses 3.2 5.5 7.6 1.8 -2.6 -2.8 -2.1
Average weekly champagne plus white wine intake 0.3 0.4 0.7 0.8 -0.4 -0.2 0.7
Miserableness 2.8 4.8 13.2 0.5 -1.2 -3.6 -2.1
Guilty feelings 0.4 0.7 1.7 0.2 -0.8 -1.3 -0.6
Wears glasses or contact lenses 0.1 0.2 0.3 -0.1 -0.5 0.2 -0.6
Ever taken oral contraceptive pill 0.4 0.4 1.0 0.7 -0.3 1.0 -0.3
Hearing aid user 0.1 0.1 0.4 0.2 -0.6 -0.2 0.1
Mother’s age at death 0.4 0.5 1.5 0.1 -0.5 -1.2 0.4
Financial situation satisfaction 3.3 4.1 8.4 1.7 -1.9 -1.2 -2.9
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.8 -0.2 0.1 0.4 0.9
Commuting to job workplace: Public transport 4.9 5.9 9.5 -2.2 2.9 0.8 3.1
Eye problems/disorders: Glaucoma 1.6 1.9 3.7 1.7 -0.6 -1.9 -0.6
Medication: Blood pressure 0.6 1.1 3.0 1.7 -1.1 0.2 -0.4
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.5 0.3 -1.1 0.7 -1.2
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.5 0.7 -0.2 1.6 -1.1
High cholesterol (Self-reported) 2.7 4.9 8.6 -0.8 2.9 2.9 1.4
Medication: Bendroflumethiazide 0.5 0.7 1.5 1.0 0.5 1.2 0.2
Medication: Paracetamol 1.4 2.2 5.4 -2.3 0.5 -1.0 1.5
Medication: Lisinopril 0.2 0.2 0.6 0.8 -0.3 -0.1 -0.3
Medication: Atorvastatin 1.9 2.3 3.4 -1.8 1.7 1.6 0.7
Illnesses of father: High blood pressure 3.4 4.3 8.6 1.6 -2.2 -1.1 -2.9
Alcohol drinker status: Never 0.2 0.2 0.4 -0.6 0.5 -0.1 0.5
Ever smoked 0.5 0.9 3.0 -0.3 -0.5 1.7 0.4
Basal metabolic rate 0.8 4.2 11.0 -3.3 1.1 2.1 0.3
Leg fat percentage (left) 0.1 0.4 0.7 -0.1 0.9 -0.8 -0.1
Arm fat-free mass (left) 0.7 3.5 9.1 -3.0 0.9 2.0 0.2
Number of operations (self-reported) 0.7 1.0 2.2 -0.4 -1.5 -1.3 0.1
Average weekly beer plus cider intake 1.1 1.6 2.9 -1.1 -1.0 -1.1 -1.7
Irritability 0.5 0.8 2.5 0.7 -0.6 -1.6 -0.3
Risk taking 1.6 2.4 5.6 1.1 -2.4 0.1 -1.6
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.0 0.6 -1.4 -1.4 -0.7
Fractured/broken bones in last 5 years 1.1 1.4 3.4 -1.0 0.8 0.8 1.8
Age started oral contraceptive pill 1.8 2.2 3.7 -1.1 1.9 0.5 1.9
Diastolic blood pressure, automated reading 1.2 3.6 6.4 2.0 -2.0 -0.4 -2.5
Ever depressed for a whole week 4.3 5.3 7.2 1.7 -2.7 -2.5 -2.2
Unable to work because of sickness or disability 1.2 1.6 3.3 -1.0 1.1 -0.9 1.8
Commuting to job workplace: Cycle 1.2 1.4 3.7 -1.9 1.2 0.0 0.8
Myopia 0.1 0.1 0.2 0.1 -0.3 -0.5 0.1
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.5 -0.6 -0.3 -1.2 0.5
Cholesterol lowering medication 0.8 1.2 1.8 -1.0 1.3 0.6 1.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.9 -0.3 -0.1 -1.0 -0.3
Pain experienced in last month 0.9 1.5 2.6 -0.7 1.6 0.1 1.6
Supplements: Calcium 0.6 0.7 1.6 1.3 -1.0 0.3 0.2
Basal cell carcinoma (self-reported) 0.5 0.6 2.0 0.0 0.5 1.4 0.1
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.4 -0.9 1.2 1.1 0.0
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.2 -1.5 0.1 -0.8 0.8
Heart disease (siblings) 0.4 0.5 0.7 0.8 0.4 -0.9 0.8
Alcohol drinker status: Previous 9.0 10.3 14.7 -3.4 3.8 2.2 3.2
Pack years of smoking 6.3 9.2 13.4 -2.1 2.9 3.2 3.7
Impedance of whole body 15.4 78.3 106.1 10.3 -9.0 -7.3 -8.6
Leg fat mass (left) 0.3 1.1 2.5 -1.6 1.3 0.3 0.1
Arm predicted mass (left) 0.8 3.8 10.1 -3.2 1.0 2.0 0.2