TWAS hub - SEMA3B-AS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.666	0.0750	4.1e-05	-0.001	NA	0.118	NA	0.020	3.6e-01	NA	5.0e-07	NA	2.8e-02
2	GTEx	Artery Tibial	0.730	0.0502	6.1e-14	0.071	NA	0.305	NA	0.184	3.3e-06	NA	2.6e-24	NA	2.1e-14
3	GTEx	Brain Cortex	0.670	0.1140	6.0e-05	-0.011	NA	-0.011	NA	0.010	9.4e-01	NA	9.7e-01	NA	1.7e-01
4	GTEx	Brain Putamen basal ganglia	0.177	0.0900	3.8e-03	0.047	NA	0.027	NA	0.032	2.9e-02	NA	7.8e-02	NA	6.0e-02
5	GTEx	Cells Transformed fibroblasts	0.149	0.0860	1.0e-03	0.008	NA	-0.001	NA	-0.003	7.3e-02	NA	3.9e-01	NA	6.8e-01
6	GTEx	Colon Transverse	0.530	0.1370	2.6e-03	-0.003	NA	-0.003	NA	-0.006	4.8e-01	NA	5.1e-01	NA	8.7e-01
7	GTEx	Esophagus Muscularis	0.469	0.1530	1.2e-03	0.001	NA	-0.005	NA	-0.003	2.6e-01	NA	9.7e-01	NA	5.9e-01
8	GTEx	Heart Atrial Appendage	0.624	0.0890	1.6e-09	0.171	NA	0.324	NA	0.179	3.9e-08	NA	3.8e-15	NA	1.9e-08
9	GTEx	Heart Left Ventricle	0.563	0.0989	2.0e-06	0.021	NA	0.208	NA	0.076	2.6e-02	NA	2.7e-11	NA	7.7e-05
10	GTEx	Muscle Skeletal	0.168	0.0735	7.7e-05	0.005	NA	0.014	NA	0.017	9.3e-02	NA	1.3e-02	NA	8.2e-03
11	GTEx	Nerve Tibial	0.249	0.1204	3.5e-05	0.036	NA	0.003	NA	0.030	1.3e-03	NA	1.8e-01	NA	3.3e-03
12	GTEx	Vagina	0.755	0.1000	4.6e-04	-0.013	NA	-0.003	NA	0.030	9.5e-01	NA	3.8e-01	NA	7.0e-02
13	ROSMAP	Brain Pre-frontal Cortex	0.368	0.0852	4.6e-05	0.000	0.009	0.053	0.058	0.001	3.6e-01	0.019	2.0e-07	6.2e-08	2.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	7	8	9	10	11	12	13
Impedance of leg (right)	11.9	57.6	132.2	6.8	6.9	6.5	6.5	7.5	10.6	7.9	7.1	11.5	10.1	7.2	1.1
Impedance of leg (left)	11.0	53.6	123.2	6.6	6.6	6.4	6.0	7.4	10.4	8.0	6.8	11.1	9.5	6.8	0.9
Tense / ‘highly strung’	10.1	16.7	26.7	4.5	4.3	4.4	3.1	5.1	4.6	3.9	4.0	5.2	4.4	2.3	4.3
Impedance of whole body	9.3	47.2	118.8	5.5	6.5	5.9	5.1	6.7	9.5	6.1	7.0	10.9	8.7	7.8	0.6
Worrier / anxious feelings	9.1	17.1	40.7	6.4	4.2	4.9	1.7	5.4	3.5	5.1	4.5	4.6	3.1	-0.2	4.3
Worry (Nagel 2018)	7.8	16.5	40.2	4.4	3.0	5.2	2.9	6.3	4.5	3.5	3.5	5.9	4.3	1.7	3.0
Chronotype (morning person)	7.6	17.6	38.6	-2.0	-2.2	-4.6	-5.4	-5.5	-6.0	-2.5	-2.8	-5.6	-6.2	-4.2	-1.3
Impedance of arm (right)	7.6	35.5	86.7	4.7	6.4	5.4	3.8	5.5	7.5	4.5	7.0	9.3	7.1	7.8	1.5
Had menopause	7.5	9.3	19.0	-4.4	-4.3	-1.5	-2.5	-2.4	-3.6	-2.9	-3.2	-3.8	-3.5	-0.9	-3.2
Nervous feelings	7.4	13.8	27.6	4.4	3.2	4.4	3.1	5.1	4.1	3.6	3.3	5.3	4.1	1.1	2.9
Alcohol drinker status: Previous	7.3	8.3	14.7	-3.8	-3.1	-2.3	-3.1	-1.9	-3.6	-3.3	-2.8	-3.5	-3.8	-1.7	-1.6
Falls in the last year	7.1	9.6	32.1	-5.7	-5.1	-1.6	-1.4	-0.9	-2.3	-4.0	-4.2	-2.5	-2.4	-0.2	-3.3
Neuroticism score	7.0	14.6	29.1	5.1	3.5	4.7	2.2	5.4	4.5	4.1	3.0	4.8	3.8	0.9	3.3
Fractured/broken bones in last 5 years	6.7	8.7	25.4	-5.0	-4.2	-2.3	-1.5	-0.8	-2.4	-3.5	-4.2	-2.0	-2.1	-1.8	-3.8
Impedance of arm (left)	6.5	30.1	74.8	4.2	5.9	4.9	3.3	4.9	7.0	4.0	6.4	8.7	6.5	7.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted	5.8	12.1	28.5	3.2	3.5	2.4	5.3	2.3	4.7	2.9	2.4	4.8	5.3	1.9	2.2
Comparative body size at age 10	5.6	15.5	35.3	-3.1	-3.6	-3.9	-3.5	-4.9	-5.5	-3.9	-3.6	-5.9	-5.0	-2.8	-1.1
Depression (Nagel 2018)	5.3	7.9	19.1	2.8	2.1	3.4	2.1	4.4	3.9	1.9	2.3	4.2	3.5	1.7	0.9
Severe depression (siblings)	5.2	5.8	12.2	1.6	1.9	3.5	2.6	2.7	2.8	1.4	1.9	3.3	3.1	2.7	1.4
Commuting to job workplace: Public transport	5.0	6.0	18.0	-2.9	-3.1	-1.1	-4.2	-0.7	-3.2	-2.7	-0.9	-1.9	-3.6	-0.9	-2.0
Pack years of smoking	5.0	7.4	16.7	-1.7	-2.0	-3.1	-1.6	-2.9	-3.9	-2.3	-3.1	-4.1	-3.5	-3.0	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	4.7	6.3	15.0	2.5	2.0	2.8	2.3	3.9	3.5	1.4	1.4	3.7	3.4	0.9	1.0
Neuroticism	4.6	11.1	22.8	4.1	2.8	4.3	2.0	4.8	4.0	3.4	2.8	4.3	3.4	1.0	3.0
Frequency of depressed mood in last 2 weeks	4.4	6.2	21.2	2.7	1.1	3.6	1.4	4.6	3.0	1.5	2.1	3.4	2.7	-0.1	0.9
Health satisfaction	4.3	5.6	11.8	2.5	2.0	2.6	3.1	3.3	3.2	1.6	1.2	3.0	3.4	0.4	0.9
Happiness	4.2	5.1	12.6	3.5	3.0	2.2	1.4	2.3	2.2	3.3	1.3	2.9	2.0	0.4	1.7
Neuroticism (Nagel 2018)	4.1	9.6	27.4	3.3	2.2	4.1	2.0	5.2	3.8	2.5	2.0	4.4	3.5	1.3	1.8
Smoking Status	4.1	9.9	24.7	-3.5	-3.4	-4.1	-1.0	-2.6	-2.5	-3.5	-5.0	-3.8	-2.4	-2.2	-3.6
Relative age of first facial hair	4.1	8.5	31.1	-0.1	-0.2	1.1	5.5	1.9	4.8	0.8	-1.9	3.1	5.6	1.9	-1.9
Lung FVC	4.0	20.1	43.5	-5.5	-4.7	-3.6	-4.2	-4.3	-6.6	-5.5	-3.5	-5.3	-6.0	-2.9	-1.4
Pack years adult smoking proportion	3.9	6.0	13.5	-1.4	-1.6	-2.7	-1.6	-2.5	-3.6	-2.3	-2.7	-3.7	-3.2	-2.7	-1.0
Ever unenthusiastic/disinterested for a whole week	3.9	4.7	14.7	1.6	0.6	3.0	1.9	3.8	3.2	1.5	0.3	3.1	2.8	1.0	-0.1
Ever highly irritable/argumentative for 2 days	3.9	4.7	11.5	2.5	0.7	2.0	3.0	3.4	3.4	1.6	-0.4	2.3	3.1	-0.6	0.0
Neuroticism (2016)	3.8	5.5	13.2	2.9	1.9	2.9	0.7	3.6	3.0	2.6	2.1	3.4	2.2	0.5	1.3
Height	3.8	73.6	204.5	8.6	7.9	3.8	13.8	3.9	12.8	7.4	4.9	10.8	14.3	5.3	2.4
Breastfed as a baby	3.8	4.7	9.8	-3.0	-1.6	-3.1	-1.1	-3.1	-2.4	-2.7	-1.9	-2.3	-1.8	-0.4	-1.6
Smoking status: Previous	3.8	5.7	12.9	-2.0	-2.1	-3.3	0.3	-3.5	-1.2	-2.7	-3.2	-3.1	-1.0	-0.4	-3.6
Overall health rating	3.6	7.8	17.8	3.6	2.4	2.3	3.5	3.7	4.2	1.7	1.7	3.0	3.9	-0.4	1.9
Sensitivity / hurt feelings	3.5	6.1	14.5	3.8	2.8	2.8	1.3	2.8	2.7	3.2	1.6	3.1	2.4	1.0	1.6
Ever used hormone-replacement therapy (HRT)	3.5	4.5	12.5	-3.5	-3.2	-1.7	0.2	-0.5	-0.4	-3.2	-2.8	-1.6	-0.4	-0.9	-3.3
Past tobacco smoking	3.5	6.5	17.1	2.5	2.6	3.3	0.3	2.9	1.5	2.7	3.9	2.9	1.2	0.3	4.1
Waist Hip Ratio (WHR)	3.2	14.4	44.0	1.6	0.9	3.6	3.6	5.6	5.6	1.9	1.5	6.6	5.4	3.8	-0.6
Stomach or abdominal pain in last month	3.2	4.0	8.6	1.8	1.6	2.0	1.4	2.9	2.3	1.7	2.4	2.9	2.2	1.4	1.6
Allergy	3.2	7.3	16.7	1.9	3.0	-2.3	-4.1	-2.9	-3.1	2.5	1.6	-2.9	-3.5	-2.1	3.0
Commuting to job workplace: Walk	3.2	3.4	9.0	-2.4	-2.4	-0.4	-2.9	-0.6	-3.0	-1.4	-0.6	-0.8	-2.3	-0.8	-2.5
Standing height	3.1	30.6	85.2	5.3	4.9	2.5	9.0	2.3	8.3	4.7	3.0	7.0	9.2	3.8	1.3
Blood Eosinophil Count	3.0	23.4	70.1	-2.9	-4.9	-1.1	8.4	2.2	5.8	-2.8	-6.0	3.3	7.2	0.5	-7.4
Taking other prescription medications	3.0	4.6	12.7	1.0	-0.8	1.3	3.6	3.0	3.5	0.4	-1.6	2.3	3.5	-0.9	-1.1
Age when periods started (menarche)	3.0	7.1	27.7	1.1	0.6	-0.4	5.3	0.1	5.0	1.9	-0.3	2.1	5.2	1.7	-0.6
Pulse wave reflection index	3.0	3.7	11.6	-1.8	-2.0	-2.2	-0.0	-1.8	-1.9	-1.8	-3.4	-2.5	-1.4	-2.1	-1.2
Commuting to job workplace: Car/motor vehicle	3.0	3.4	10.6	3.3	2.9	0.2	2.5	-0.8	1.6	2.5	1.0	-0.1	1.6	-0.3	2.4
Breast cancer (self-reported)	3.0	3.6	7.6	-2.0	-2.6	-2.8	-1.0	-1.5	-1.4	-1.8	-2.6	-2.1	-1.2	-0.8	-2.5
Body Mass Index (BMI) (2010)	2.9	4.0	9.5	-2.8	-2.2	-1.3	-1.6	-0.7	-2.0	-3.1	-2.7	-2.5	-2.2	-1.7	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	2.9	6.5	10.6	2.7	1.8	2.4	3.0	2.6	3.3	3.1	2.2	3.0	3.2	0.3	2.9
Mood swings	2.8	5.1	12.7	3.6	1.6	3.0	1.2	3.5	2.8	2.2	1.6	2.2	2.1	-0.2	2.0
Ever smoked	2.8	4.9	16.1	-2.5	-2.7	-2.4	-0.0	-1.8	-1.0	-2.4	-3.7	-2.0	-0.7	0.1	-4.0
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.1	12.0	3.3	2.0	2.0	3.5	1.6	3.1	2.9	2.1	2.3	3.2	0.2	2.7
Friendships satisfaction	2.7	3.3	9.5	1.1	1.2	2.1	0.8	2.9	2.4	1.8	0.9	3.1	2.2	1.8	-0.6
Ever had prostate specific antigen (PSA) test	2.7	3.1	6.4	2.5	1.7	2.3	2.1	0.6	1.3	0.8	2.5	1.5	1.9	1.3	2.1
BMI	2.6	15.1	46.2	-1.9	-4.0	-2.3	-2.7	-2.4	-4.7	-3.9	-4.2	-6.8	-4.8	-5.8	0.5
Body mass index (BMI)	2.6	11.1	31.6	-1.7	-3.2	-2.1	-2.1	-1.9	-3.9	-3.2	-3.8	-5.6	-3.9	-5.5	0.8
Time employed in main current job	2.6	3.0	14.3	-0.9	-0.7	-0.3	-3.8	-0.8	-2.5	-0.9	0.1	-1.9	-3.5	0.1	0.5
Asthma (self-reported)	2.6	5.1	12.4	-1.9	-3.5	1.6	3.3	1.6	1.7	-2.9	-2.1	1.2	2.4	0.7	-3.3
Pulse rate, automated reading	2.5	8.2	19.5	2.9	2.4	2.4	1.1	4.1	4.2	2.4	3.3	4.4	3.0	1.7	1.7
Family relationship satisfaction	2.4	2.9	7.6	0.7	0.5	1.6	2.4	2.2	2.6	1.8	-0.5	2.2	2.8	0.9	-0.6
Mean Putamen Volume	2.3	2.7	6.4	-1.6	-1.8	1.8	1.5	1.9	1.4	-1.2	-0.8	1.8	1.8	2.5	-1.8
Current tobacco smoking	2.3	3.8	9.8	-2.6	-2.6	-2.0	-1.0	-0.3	-1.5	-2.3	-3.1	-2.0	-1.5	-1.8	-2.0
Number of incorrect matches in round	2.3	3.8	9.6	-1.7	-1.3	-1.6	-1.4	-2.4	-3.1	-2.4	-1.1	-2.9	-2.3	-1.8	-0.7
Mouth/teeth dental problems: Dentures	2.3	3.8	13.8	-1.3	-2.4	-2.0	1.0	-0.6	-0.9	-1.9	-3.1	-2.5	-0.7	-3.7	-1.5
Asthma	2.3	4.5	11.0	-1.4	-3.1	1.6	3.3	1.7	1.7	-2.4	-1.9	1.3	2.4	0.6	-3.2
Financial situation satisfaction	2.3	2.8	8.3	2.0	1.2	1.4	2.3	1.3	2.9	2.1	0.0	1.7	2.5	0.5	0.1
Respiratory disease	2.2	5.0	13.6	-1.9	-3.5	1.2	3.2	1.7	1.2	-2.4	-2.9	0.9	2.1	0.7	-3.7
Hayfever, allergic rhinitis or eczema	2.2	4.7	9.9	-0.9	-1.5	2.0	3.1	2.8	2.9	-1.5	-0.8	3.1	3.1	2.0	-1.5
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	7.6	1.2	1.1	2.4	2.1	2.8	2.6	1.5	1.5	2.6	2.6	1.1	0.8
Medication: Gliclazide	2.2	2.4	5.0	2.0	1.7	2.2	0.4	1.4	1.4	2.2	2.0	1.4	1.1	1.5	1.2
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	5.8	0.7	0.3	2.2	1.6	2.4	2.4	0.5	1.0	2.1	1.9	0.1	1.0
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	8.8	0.8	0.2	1.0	2.3	2.1	3.0	0.6	0.1	2.8	2.7	-0.2	-0.5
Birth weight of first child	2.1	3.7	8.8	-2.0	-2.1	-0.7	-2.3	-2.3	-3.0	-1.9	-1.4	-2.3	-2.8	0.6	-1.4
Number of full brothers	2.1	2.6	8.3	-2.3	-2.9	-0.2	-0.7	0.3	-1.3	-1.9	-2.3	-1.3	-1.1	-1.8	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.8	9.7	1.2	0.3	3.1	0.7	2.9	1.6	0.7	1.1	2.0	1.5	2.2	0.8
High cholesterol (Self-reported)	2.1	3.7	10.1	-0.5	0.0	-2.9	-1.9	-2.4	-2.1	-0.7	-0.8	-2.5	-2.8	-3.2	0.2
Bipolar Disorder (2018)	2.0	3.2	6.4	2.5	1.6	1.8	2.1	1.2	2.1	1.8	1.8	1.8	2.4	1.2	1.6
Crohns Disease (2012)	2.0	3.2	15.1	2.2	3.9	0.1	-1.1	-1.6	-0.9	1.4	2.2	-0.6	-1.2	-0.1	2.8
Medication: Simvastatin	2.0	2.9	6.7	-1.2	-1.5	-2.0	-1.2	-2.0	-1.8	-1.5	-1.7	-2.6	-2.1	-2.0	-1.1
Medication: Ventolin 100micrograms inhaler	2.0	2.5	6.9	-0.4	-1.8	-0.5	2.6	0.7	1.9	-1.3	-2.6	1.2	1.8	-0.4	-2.2
Wheeze or whistling in the chest in last year	2.0	3.5	13.6	-0.0	-0.9	1.8	3.7	1.9	2.8	-1.1	-0.6	1.9	3.3	0.9	-0.7
Townsend deprivation index at recruitment	1.9	2.7	6.3	-1.0	-1.8	-2.1	-0.7	-1.4	-1.1	-0.3	-2.5	-1.8	-1.1	-2.2	-2.5
Frequency of tenseness / restlessness in last 2 weeks	1.9	3.0	9.1	2.4	0.9	1.4	1.3	3.0	2.7	1.2	0.2	2.0	2.2	-1.2	0.9
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	6.3	2.1	2.1	2.4	-0.1	1.6	0.8	1.7	2.4	2.5	0.8	1.5	1.7
Birth weight	1.9	4.2	7.7	-2.1	-2.4	-2.3	-1.4	-2.5	-2.4	-2.8	-2.0	-2.2	-2.2	-0.5	-2.0
Miserableness	1.9	3.3	12.7	1.7	0.8	2.9	0.7	3.6	2.6	0.8	0.7	2.2	1.8	0.6	1.3
Eye problems/disorders: Glaucoma	1.9	2.3	8.9	2.3	1.7	2.0	0.2	1.8	0.8	3.0	1.2	1.0	0.9	-0.4	1.0
Ever depressed for a whole week	1.9	2.3	5.9	1.7	0.3	1.0	2.3	2.1	2.2	0.7	-0.8	1.6	2.4	-1.0	-0.7
Hand grip strength (right)	1.8	4.8	11.9	3.2	3.0	-0.7	3.4	-1.9	2.2	1.7	1.8	0.3	2.3	0.2	3.4
Relative age voice broke	1.8	2.8	9.4	0.4	0.1	-0.3	3.0	0.5	2.8	1.1	-1.5	1.5	3.1	0.5	-1.8
Alcohol intake versus 10 years previously	1.8	2.7	9.1	1.3	0.2	1.3	2.4	1.9	3.0	1.1	0.5	1.6	2.9	-0.0	0.3
Mean time to correctly identify matches	1.8	3.5	15.0	-0.4	-0.1	-1.0	-3.0	-1.5	-3.9	-0.8	-0.1	-2.4	-3.2	-1.2	0.2
Leg pain on walking	1.8	2.2	9.8	-0.8	-0.9	-1.3	3.1	0.1	2.0	0.5	-1.6	0.0	2.4	-1.8	-0.8
Number of self-reported non-cancer illnesses	1.8	3.1	8.6	0.8	-0.1	2.1	2.6	2.9	2.6	1.1	0.0	2.3	2.5	0.1	-0.5
Crohns Disease (2017)	1.7	3.7	18.2	2.5	4.3	-0.2	-1.5	-2.1	-0.6	1.7	1.9	-0.9	-1.3	0.7	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	6.4	2.3	0.8	2.2	1.7	2.5	1.9	1.2	0.8	1.5	2.1	0.7	1.0
Eye problems/disorders: None of the above	1.7	2.0	8.4	-0.4	-0.7	-2.3	-0.2	-2.9	-1.5	-1.0	-0.8	-2.3	-1.3	-0.9	-0.0
Illnesses of siblings: Diabetes	1.7	2.1	8.4	-0.2	-0.9	0.8	1.5	2.9	1.9	0.4	-1.5	1.8	1.9	-0.8	-1.1
Commuting to job workplace: Cycle	1.7	2.1	5.1	-2.2	-1.9	-0.9	-2.3	-0.3	-1.2	-1.6	-1.8	-0.4	-1.7	-0.6	-1.4
Allergy or Eczema	1.6	4.1	8.7	-2.3	-2.9	-0.1	3.0	1.4	1.7	-2.2	-2.6	1.4	2.2	0.6	-2.8
Type 2 Diabetes (T2D) (2018)	1.6	3.0	6.3	2.4	1.8	0.7	1.5	1.1	2.4	2.5	1.3	1.7	1.9	0.5	2.5
Medication for hormone replacement therapy	1.6	1.7	5.0	-2.2	-1.5	-0.8	1.8	-0.5	1.4	-1.6	-1.2	-0.1	1.1	1.4	-1.4
Fed-up feelings	1.6	2.9	7.0	2.6	1.5	1.2	0.9	2.4	2.4	1.2	1.3	1.7	1.6	-0.8	2.3
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	8.9	-2.2	-1.7	-0.9	0.4	0.6	0.2	-3.0	-2.0	-0.6	-0.0	-0.5	-0.9
Medication: Amlodipine	1.6	2.2	5.6	-0.0	-0.8	-1.7	-0.3	-1.6	-1.4	-0.6	-2.3	-1.9	-1.2	-2.4	-2.2
Shortness of breath walking on level ground	1.6	1.9	6.3	-2.5	-2.3	0.2	1.0	1.3	0.9	-1.2	-1.7	0.3	1.0	0.4	-1.8
Medication: Aspirin	1.6	2.1	7.5	-0.7	-1.0	-1.7	0.1	-1.8	-1.4	-0.6	-2.0	-1.7	-1.1	-2.7	-1.1
Smoking status: Current	1.6	2.5	7.1	-2.2	-2.3	-1.3	-1.0	0.2	-1.2	-1.9	-2.7	-1.4	-1.2	-1.1	-1.7
Ever taken oral contraceptive pill	1.6	1.8	5.6	-2.1	-1.7	-1.0	0.7	-1.0	-0.1	-2.4	-1.8	-0.9	0.2	1.1	-1.7
Illnesses of father: High blood pressure	1.6	2.0	7.1	0.1	-0.2	0.6	2.4	1.2	2.7	0.3	-1.1	2.1	2.3	-0.1	-0.8
Unable to work because of sickness or disability	1.6	2.1	4.7	-2.0	-2.0	0.1	-2.1	1.4	-1.5	-2.2	-1.2	-0.2	-1.7	0.3	-1.0
Blood Red Count	1.5	14.8	33.9	3.7	2.6	3.0	4.4	4.0	5.8	3.5	3.5	5.4	5.2	3.0	1.7
Average weekly spirits intake	1.5	1.9	4.3	1.0	0.5	1.9	2.0	2.0	1.7	0.5	0.8	1.4	2.1	0.9	0.9
Alcohol usually taken with meals	1.5	2.5	5.7	2.0	1.7	1.8	1.4	-0.1	1.1	1.9	1.8	1.9	1.4	2.4	0.9
Pulse rate	1.5	2.5	8.2	1.0	1.0	1.8	-0.0	2.9	1.9	1.2	2.1	2.7	1.3	0.4	0.9
Worry too long after embarrassment	1.5	2.5	5.4	2.3	2.1	1.9	-1.4	2.3	0.4	2.1	1.1	1.5	0.2	0.1	1.7
Cholesterol lowering medication	1.5	2.2	5.7	-0.5	-1.1	-1.4	-2.0	-0.8	-1.6	-0.9	-1.4	-2.1	-2.1	-2.4	-1.0
Illnesses of siblings	1.4	2.0	7.0	-1.3	0.0	-2.7	-1.6	-2.4	-1.3	-0.7	-0.3	-1.8	-1.7	-0.0	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	5.8	-1.3	-0.9	-1.5	-0.3	-2.1	-1.3	-0.9	-0.7	-2.4	-1.1	-1.1	-0.2
Age at first live birth	1.4	2.5	8.2	1.3	2.9	0.6	-1.4	-0.3	-1.5	-0.2	2.6	1.1	-1.0	2.1	2.2
Pulse wave peak to peak time	1.4	1.7	6.8	1.9	1.6	1.6	-0.8	0.2	-0.2	0.9	2.6	0.4	-0.5	0.9	1.8
Suffer from ‘nerves’	1.4	2.2	7.5	1.8	0.7	2.5	0.1	2.7	0.4	0.9	1.8	1.9	0.6	-0.0	1.4
Age at last live birth	1.4	2.1	5.4	-0.7	1.5	-0.1	-2.3	-1.3	-2.3	-1.2	1.5	0.2	-2.1	2.0	0.6
Irritable Bowel Disease (IBD)	1.3	3.1	15.2	2.2	3.9	-0.6	-2.2	-1.5	-0.7	2.2	1.4	-0.2	-1.6	0.5	1.4
Ulcerative Colitis	1.3	1.8	7.9	0.6	1.3	-0.6	-2.8	-1.0	-2.0	0.8	-0.2	-1.0	-2.7	0.0	-0.0
Blood Platelet Count	1.3	14.7	32.6	-2.9	-2.6	-5.2	-3.4	-5.0	-5.0	-1.7	-4.5	-5.7	-4.9	-2.5	-1.4
Illnesses of mother	1.3	1.6	5.1	-2.3	-1.6	-0.3	-2.1	-0.1	-1.8	-1.3	0.2	-1.1	-1.5	0.6	0.1
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	5.3	0.7	2.3	0.8	1.2	-0.2	1.4	1.2	0.7	1.6	1.6	2.2	0.9
Number of children fathered	1.3	1.5	4.4	1.8	1.5	0.3	1.8	-0.1	1.6	1.0	0.6	0.1	1.6	0.4	2.1
Qualifications: College or University degree	1.3	4.0	14.5	0.6	1.7	2.0	-3.8	-0.3	-2.5	0.2	2.4	0.6	-2.9	2.8	1.0
Loneliness, isolation	1.3	1.8	5.7	0.7	-0.2	1.1	2.4	1.4	2.2	1.2	-0.4	1.5	2.2	-0.6	-0.5
Age started oral contraceptive pill	1.3	1.6	4.8	-1.6	-0.8	0.5	-2.2	-0.9	-1.7	-0.5	0.8	-1.0	-2.1	1.1	-1.1
Alzheimer’s Disease (in father)	1.2	1.3	5.8	1.5	1.9	0.6	0.0	0.2	0.7	1.2	1.6	0.5	0.2	0.1	2.4
Reaction Time	1.2	2.2	9.4	0.4	0.7	-0.0	-2.9	-0.4	-3.1	-0.4	0.8	-1.3	-2.5	-0.7	1.2
Verbal and Numeric Reasoning (VNR)	1.2	2.8	9.7	0.9	1.2	-1.1	-3.1	-2.1	-2.5	-0.6	0.3	-1.3	-3.1	0.0	0.7
HbA1C	1.2	1.4	10.9	0.3	0.4	-1.9	-0.7	-0.9	-0.7	-0.3	-0.4	-0.6	-0.9	-3.3	-0.2
Rheumatoid Arthritis	1.2	1.7	5.1	1.4	1.4	1.8	-1.1	0.6	-0.2	1.9	2.3	0.3	-0.5	0.9	1.8
Qualifications: None of the above	1.2	2.5	8.1	-1.1	-1.8	-2.3	1.2	-0.3	0.5	-0.5	-2.8	-1.6	0.4	-2.5	-1.9
Length of working week for main job	1.2	1.3	4.1	0.8	1.0	0.5	-1.9	-0.8	-1.6	1.0	1.0	-0.7	-2.0	-0.1	1.3
Medication: Omeprazole	1.2	1.5	5.4	-1.8	-2.3	0.2	0.7	1.2	0.9	-1.5	-1.9	0.5	0.4	-0.1	-1.2
Tinnitus: Yes, now most or all of the time	1.2	1.4	8.4	-2.1	-2.9	-0.5	-0.3	-0.3	-0.8	-0.7	-0.6	-0.5	-0.4	0.0	-1.6
Depressed Affect (Nagel 2018)	1.1	2.2	7.2	1.2	0.4	1.9	1.4	2.7	2.6	0.8	0.0	1.8	1.8	0.2	0.6
Lupus	1.1	1.6	7.5	-1.2	-0.4	-0.6	2.7	-1.1	2.0	0.5	-1.1	0.3	2.0	-0.3	-0.7
Vitamin and mineral supplements	1.1	1.5	4.3	-0.1	0.0	-0.9	-2.0	-0.9	-1.5	-0.1	0.0	-1.8	-2.1	-1.8	0.5
Maternal smoking around birth	1.1	1.6	6.1	-0.5	-0.2	-1.4	-0.8	-2.1	-1.3	0.3	-1.1	-2.5	-1.5	-1.0	1.1
Had other major operations	1.1	1.4	6.6	-1.4	-1.3	1.7	0.6	1.1	0.6	-0.1	-0.4	0.6	0.8	2.6	-1.2
Pulse wave Arterial Stiffness index	1.1	1.3	5.0	-1.4	-1.1	-1.4	1.3	-0.1	0.8	-0.5	-2.2	0.0	1.0	-0.7	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.2	0.1	0.7	0.5	1.4	1.4	2.1	1.0	0.5	1.7	1.9	0.8	0.4
Medication: Aspirin	1.1	1.4	6.6	-0.0	-0.1	-1.5	0.3	-1.7	-1.1	-0.1	-1.4	-1.4	-0.8	-2.6	-0.5
Medication: Atorvastatin	1.1	1.4	4.4	-0.7	-1.0	-2.1	-1.2	-0.8	-1.2	-0.3	-1.0	-1.4	-1.7	-1.6	-0.0
Risk taking	1.1	1.6	4.3	-1.4	-1.8	-1.0	1.9	-0.3	1.2	0.7	-2.1	-0.2	1.4	-0.9	-1.4
Systolic Blood Pressure	1.0	5.1	20.5	1.9	1.4	-0.6	4.5	0.1	3.9	2.6	-0.1	1.9	3.6	-0.8	-0.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	6.4	0.7	0.8	1.2	-0.7	2.5	-0.2	-0.5	0.5	1.0	-0.1	-0.8	1.6
Medication: Atenolol	1.0	1.2	3.8	-1.3	-1.5	-1.0	1.6	0.4	0.5	-1.1	-1.9	0.0	0.7	-0.7	-1.5
Hearing difficulty/problems with background noise	1.0	1.5	3.4	-1.1	-1.0	-1.6	-1.5	-1.2	-1.4	0.3	-1.9	-1.6	-1.4	-0.7	-1.1
Hair/balding pattern: Pattern 2	1.0	1.3	2.6	-0.8	-1.3	1.2	1.0	1.6	0.6	-1.2	-1.4	1.0	0.8	1.3	-1.4
Qualifications: A levels/AS levels or equivalent	1.0	2.3	6.1	1.6	2.5	0.9	-1.9	-0.5	-1.8	0.6	1.8	1.1	-1.5	2.2	1.0
Peak expiratory flow (PEF)	1.0	2.2	6.3	-1.9	-2.2	-1.6	0.1	-2.1	-0.4	-0.8	-2.5	-0.7	-0.4	-0.1	-2.3
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.7	-1.2	-1.8	-0.4	1.3	0.3	0.8	-1.5	-1.9	-0.4	0.5	-0.1	-1.5
Emphysema/chronic bronchitis	1.0	1.1	4.4	-1.1	-1.1	-0.9	0.4	-1.5	-0.8	-0.9	-2.1	-0.8	-0.6	0.7	-1.0
Migraine (self-reported)	1.0	1.2	3.0	1.4	1.5	0.3	0.7	0.6	1.4	1.7	0.1	1.4	1.2	1.0	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	3.8	-1.9	-0.9	-1.2	-0.3	-0.9	-0.2	-0.4	-1.9	-0.4	-0.5	0.6	-1.9
Chest pain or discomfort	1.0	1.4	6.3	0.4	-0.0	1.2	2.5	1.1	1.6	0.1	0.2	1.2	2.1	-0.0	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.3	1.2	0.1	1.5	1.3	1.5	1.3	0.7	0.2	1.4	1.8	0.2	0.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.8	-1.8	-2.2	0.5	1.9	0.2	1.2	-0.7	-1.1	0.2	1.6	1.4	-1.0
Back pain experienced in last month	1.0	1.4	4.7	0.6	1.1	0.8	1.8	0.8	1.8	1.2	1.0	1.0	2.2	1.0	0.4
Average weekly champagne plus white wine intake	1.0	1.4	6.9	-1.4	-1.5	0.1	-0.9	-0.3	-0.8	-1.2	-1.0	0.3	-0.5	1.4	-2.6
Medication: Bendroflumethiazide	1.0	1.5	4.0	-0.6	-0.9	-2.0	-0.0	-0.9	-0.7	-1.0	-2.0	-1.4	-1.2	-1.8	-1.3
Supplements: Calcium	1.0	1.1	3.4	-1.7	-1.8	-1.1	0.6	-0.4	-0.6	-0.7	-1.8	-0.5	0.2	-0.4	-1.4
Bipolar Disorder or Schizophrenia	0.9	2.1	4.4	1.8	1.3	1.6	1.7	0.5	1.6	1.9	1.4	1.5	2.1	0.3	1.1
Schizophrenia vs Biploar Disorder	0.9	1.2	5.6	-1.0	0.2	-0.4	-2.4	-1.6	-1.3	0.1	-0.0	-0.8	-1.8	-0.0	-0.5
Major Depression (MDD)	0.9	1.1	3.9	1.5	0.8	1.0	0.8	1.4	1.3	2.0	0.4	1.0	1.3	0.0	-0.0
Breast Cancer	0.9	2.3	7.5	-0.6	-0.1	-0.5	-2.3	-2.3	-2.5	-0.5	-0.5	-1.8	-2.7	0.6	0.4
Prostate Cancer	0.9	1.2	3.8	-0.0	-1.1	0.5	1.4	1.9	1.6	-0.2	-0.6	1.1	1.7	-0.9	-1.0
Coronary Artery Disease (CAD)	0.9	1.0	2.8	-1.7	-1.4	-1.1	0.0	-0.4	-0.5	-0.5	-1.6	-1.2	-0.6	-1.5	-0.3
Ever had hysterectomy (womb removed)	0.9	1.0	3.1	-1.5	-1.3	0.5	0.5	0.7	1.0	-1.8	0.1	0.2	0.7	1.5	-1.1
Qualifications: CSEs or equivalent	0.9	1.1	4.8	-0.0	0.1	0.1	2.2	0.0	2.1	0.4	-0.5	0.6	2.2	0.0	-0.4
Multivitamins +/- minerals	0.9	1.1	3.7	-0.8	-1.3	-0.6	1.8	0.1	0.9	-0.5	-1.2	0.6	1.4	0.0	-1.9
Mouth/teeth dental problems	0.9	1.4	5.8	1.3	0.8	0.7	-2.4	0.4	-0.8	1.3	2.1	0.4	-1.2	-0.2	1.1
Hip circumference	0.9	4.0	14.8	-0.2	-1.2	-1.8	-0.3	-1.9	-2.1	-1.6	-2.5	-3.3	-1.8	-3.8	1.1
Medication: Cholesterol lowering	0.9	1.4	4.7	-0.3	-0.2	-2.1	0.1	-1.6	-0.6	-0.5	-0.9	-1.7	-1.0	-2.2	0.7
Medication: Lansoprazole	0.9	1.0	2.1	1.4	1.1	1.1	0.2	1.4	1.0	0.9	0.9	1.3	0.9	-0.0	1.4
High blood pressure (siblings)	0.9	1.3	4.5	0.7	-0.7	1.4	2.1	1.3	1.6	-0.3	-0.6	1.1	1.6	-0.2	-0.9
Angina (self-reported)	0.9	1.2	4.2	-0.2	-0.5	-0.3	-1.6	-0.0	-1.3	1.4	-1.0	-1.1	-1.6	-2.1	0.5
Medication: Seretide 50 evohaler	0.9	1.0	3.7	-0.1	-1.9	0.4	0.9	1.3	-0.1	-1.7	-1.3	0.2	0.5	-0.3	-1.5
Illnesses of father: None of the above (group 1)	0.9	1.1	4.5	0.8	0.7	0.8	-1.5	0.1	-0.4	1.4	1.4	-0.0	-0.8	2.1	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	5.7	-0.8	-0.8	-1.0	-2.1	-1.2	-2.3	-1.4	-0.4	-1.4	-2.4	-1.1	0.8
Leg predicted mass (right)	0.9	4.8	13.2	-0.6	-1.5	-2.2	0.7	-2.7	-2.0	-2.3	-2.8	-3.6	-1.5	-3.6	1.3
Number of operations (self-reported)	0.9	1.4	5.0	-1.6	-2.2	0.1	0.8	1.4	0.1	-1.1	-1.9	0.4	0.8	0.3	-1.4
Intelligence (Savage-Jansen 2018)	0.8	2.5	15.1	0.1	1.2	-0.6	-3.9	-1.3	-2.1	-0.3	0.4	-0.3	-3.0	0.7	0.2
Triglycerides	0.8	1.3	4.0	-1.1	-1.1	-1.9	1.2	-0.9	1.3	-0.6	-1.1	0.2	1.0	0.2	-2.0
Heel T-Score	0.8	6.5	15.2	3.9	2.8	1.5	1.8	2.1	3.8	2.1	2.4	2.7	3.1	0.6	3.1
Hand grip strength (left)	0.8	2.0	5.1	2.3	1.8	-1.2	1.8	-2.2	1.2	0.7	1.1	-0.4	1.0	-0.3	2.1
Number of treatments/medications taken	0.8	1.5	4.8	1.2	-0.4	0.9	2.2	1.9	1.3	0.2	-0.8	0.9	1.5	-1.7	-0.0
Systolic blood pressure, automated reading	0.8	2.3	7.2	-0.5	-1.0	-2.2	1.1	-1.8	0.2	0.7	-2.5	-1.8	0.0	-2.7	-1.4
Serious illness, injury or assault to yourself	0.8	0.9	3.6	-1.2	-1.9	0.1	-0.7	-0.4	-0.7	-1.0	-1.2	-0.5	-0.7	-0.3	-1.5
Diabetes (self-reported)	0.8	1.2	4.6	2.0	0.9	0.3	0.5	0.5	0.8	1.8	0.7	0.2	0.6	-0.6	2.1
Fluid intelligence score	0.8	1.7	7.5	1.8	2.7	-0.2	-1.0	-1.3	-0.7	1.2	1.1	0.1	-1.0	0.3	2.0
Depression (self-reported)	0.8	1.0	3.4	1.1	0.1	1.8	0.6	1.4	0.5	0.2	0.6	0.8	0.7	1.2	1.6
Exposure to tobacco smoke at home	0.8	0.9	4.2	-0.0	-0.4	-1.0	-0.1	-0.7	-0.4	0.3	-1.4	-1.6	-0.7	-2.0	-0.8
Arm fat-free mass (right)	0.8	3.9	14.7	0.0	-1.6	-2.0	2.3	-2.2	-0.5	-0.9	-3.2	-2.8	0.1	-3.8	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	4.5	0.8	1.1	1.3	0.2	0.7	0.5	0.0	0.6	1.4	0.4	2.1	1.2
Leg fat-free mass (right)	0.8	4.4	12.3	-0.5	-1.3	-2.1	0.8	-2.6	-1.8	-2.2	-2.7	-3.5	-1.3	-3.5	1.4
Qualifications: nursing, teaching	0.8	1.2	2.9	0.0	0.8	0.9	-1.7	-0.2	-1.6	-0.2	1.5	-0.4	-1.7	1.4	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.8	1.0	0.0	0.6	1.7	1.1	1.2	1.3	-0.9	0.4	1.4	-1.2	-0.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	4.1	-1.3	-0.8	-0.6	2.0	-0.6	1.0	-0.7	-0.9	0.0	1.3	0.9	-0.5
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.4	0.7	1.2	-1.8	0.9	-1.8	0.3	0.6	-0.4	-0.6	0.3	-1.6	0.8
HDL Cholesterol	0.7	1.2	2.9	-0.1	1.6	0.5	-1.0	-1.7	-1.5	0.1	1.6	-0.6	-0.8	1.4	1.0
Diabetes (father)	0.7	0.9	3.2	-1.1	-1.1	-0.1	-0.1	1.8	0.7	-1.0	-0.9	1.5	0.4	-0.4	-1.1
Leg fat-free mass (left)	0.7	3.8	11.4	-0.2	-1.2	-1.9	1.2	-2.3	-1.6	-2.2	-2.5	-3.2	-0.9	-3.4	1.4
Leg predicted mass (left)	0.7	3.9	11.6	-0.3	-1.2	-1.9	1.3	-2.4	-1.5	-2.1	-2.6	-3.2	-0.9	-3.4	1.4
Father’s age at death	0.7	1.0	2.3	-1.3	0.0	-1.3	-0.9	-1.4	-0.7	-1.3	-0.8	-0.5	-1.2	1.5	0.1
Number of live births	0.7	1.0	3.2	-1.1	-1.2	-0.7	0.1	-0.9	0.2	-1.8	-1.8	-1.5	-0.5	-0.3	-0.7
Noisy workplace	0.7	0.9	3.3	-0.6	-1.8	0.0	-0.4	1.4	0.2	-0.6	-1.4	0.1	-0.4	-0.7	-1.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	5.7	-0.7	-0.4	1.6	-0.5	1.2	0.3	0.0	0.6	1.4	0.7	2.4	-1.0
Gout (self-reported)	0.7	0.9	2.4	1.5	0.6	0.4	1.0	0.6	1.3	1.5	-0.1	1.1	1.2	-0.5	0.8
Exposure to tobacco smoke outside home	0.7	0.9	4.8	1.0	0.6	-0.5	-0.0	-0.8	-0.3	0.1	-0.4	-1.6	-0.6	-2.2	1.4
Alcohol intake frequency.	0.7	1.7	5.7	0.6	-0.4	-0.5	2.4	1.1	2.2	0.4	-1.0	1.0	2.0	-1.8	0.9
Diabetes diagnosed by doctor	0.7	1.1	3.8	1.9	1.1	0.3	0.7	0.6	0.8	1.4	0.6	0.4	0.7	-0.8	2.0
Arm fat-free mass (left)	0.7	3.5	17.1	0.5	-1.4	-1.5	2.4	-1.5	-0.2	-0.5	-2.7	-2.5	0.3	-4.1	1.2
Average weekly beer plus cider intake	0.7	1.1	4.0	0.5	0.0	0.9	1.3	1.7	2.0	0.1	-0.3	0.7	1.5	-0.1	1.2
Diastolic blood pressure, automated reading	0.7	2.3	8.6	1.5	0.5	0.3	2.9	0.6	2.8	1.2	-0.2	1.4	2.6	0.0	0.6
Heart disease (siblings)	0.7	0.9	3.7	-0.3	-0.7	-0.3	-1.1	0.5	-1.0	-0.1	-1.3	-0.5	-0.9	-1.9	-1.2
Arm predicted mass (left)	0.7	3.6	17.4	0.3	-1.6	-1.6	2.3	-1.5	-0.3	-0.6	-2.9	-2.6	0.2	-4.2	0.9
Ulcerative Colitis (UC)	0.6	1.1	5.2	0.4	1.4	-0.5	-2.3	-0.7	-1.1	1.1	0.5	0.1	-1.8	0.6	-0.4
LDL Cholesterol	0.6	0.9	5.1	-0.5	0.8	-1.8	0.6	-2.3	-0.0	-0.6	-0.6	-1.5	0.1	0.1	0.2
Angina	0.6	0.7	3.2	-0.2	-0.6	0.0	-1.2	0.5	-0.8	1.2	-0.8	-0.6	-1.0	-1.8	0.4
Diabetes (mother)	0.6	0.8	2.7	-0.1	-0.1	-0.5	1.6	0.9	1.2	-0.5	-1.5	0.5	1.3	-0.1	-0.6
Trunk fat percentage	0.6	2.4	5.7	2.2	1.1	1.7	1.9	2.3	2.4	0.2	0.5	1.2	2.0	-0.6	1.3
Trunk fat-free mass	0.6	3.3	11.8	0.6	-0.8	-1.9	2.8	-2.3	-0.3	-0.4	-2.4	-2.4	0.7	-3.4	1.1
Prospective memory result	0.6	0.8	3.4	-0.8	-1.0	0.7	0.5	1.8	0.3	-1.1	-1.3	0.4	0.6	-0.8	-0.1
Trunk predicted mass	0.6	3.4	12.9	0.8	-0.6	-2.0	2.7	-2.4	-0.4	-0.3	-2.2	-2.4	0.6	-3.6	1.2
Loud music exposure frequency	0.6	0.7	3.2	0.3	-0.5	-0.1	-0.3	1.4	0.1	0.5	-1.6	0.6	-0.1	-1.8	-0.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	1.0	1.3	-0.6	1.3	-0.6	0.7	-0.4	-0.3	0.5	0.9	0.5	1.2
Medication for pain relief, constipation, heartburn	0.6	1.0	5.7	-0.2	0.5	0.6	0.2	0.1	1.2	1.0	1.3	1.1	1.1	2.4	-0.4
Neck or shoulder pain in last month	0.6	0.9	3.2	-0.5	-0.5	-0.9	1.5	0.1	1.5	-0.4	-1.8	0.3	1.2	-0.9	-0.5
Arm predicted mass (right)	0.6	3.0	14.4	1.0	-0.9	-1.4	2.3	-1.7	-0.1	-0.1	-2.3	-2.4	0.3	-3.8	1.2
Knee pain experienced in last month	0.6	0.9	5.9	-0.3	-0.8	-0.2	2.4	-0.1	1.0	-0.4	-0.9	-0.0	1.6	-0.8	0.3
Whole body fat-free mass	0.6	3.5	13.0	0.4	-0.9	-1.9	2.3	-2.4	-0.8	-1.0	-2.5	-2.8	0.1	-3.6	1.4
Average weekly red wine intake	0.6	0.9	4.5	-0.1	0.3	-0.7	-0.7	-2.1	-1.3	-0.6	0.6	-1.0	-1.3	0.9	0.6
Whole body water mass	0.6	3.6	13.5	0.4	-1.0	-1.8	2.1	-2.3	-0.9	-1.1	-2.5	-2.9	-0.1	-3.7	1.4
Basal cell carcinoma (self-reported)	0.6	0.8	2.7	-0.4	-0.3	-1.6	-0.5	-1.4	-0.7	-0.5	-0.8	-0.6	-0.8	-0.9	-1.3
Ovarian Cancer	0.5	0.6	2.2	-1.1	-1.3	-0.2	-0.5	-0.4	-1.5	-0.5	-0.7	-1.1	-0.8	-0.1	-0.3
Age at First Birth	0.5	0.7	3.2	0.3	1.4	0.4	0.2	0.1	-0.2	0.4	1.3	1.8	0.1	1.0	0.9
Sitting height	0.5	3.2	14.9	0.2	-0.2	-2.1	3.9	-1.4	2.4	-0.6	-1.6	0.9	3.0	-0.5	-1.3
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	0.8	0.2	0.3	0.6	1.5	1.0	-0.1	-1.3	0.6	0.8	-0.1	-0.7
Financial difficulties in last 2 years	0.5	0.7	3.4	0.5	0.0	-0.4	0.4	1.4	0.9	0.6	-1.2	0.6	0.8	-1.9	-0.3
Heart attack	0.5	0.6	3.1	-0.2	0.3	-1.1	-0.1	-0.6	-0.2	0.5	-0.8	-0.9	-0.8	-0.7	1.7
Pain all over the body in last month	0.5	0.5	2.7	0.2	-0.9	0.0	-0.9	0.8	-0.4	0.0	-0.2	-0.7	-0.7	-1.7	-0.4
Weight	0.5	2.3	11.4	0.7	-0.9	-0.8	2.1	-0.7	0.1	-0.9	-2.3	-2.1	0.5	-3.4	1.3
Lung cancer (father)	0.5	0.5	2.0	-0.0	-0.6	-0.8	-1.4	0.0	0.2	0.2	-1.2	-0.3	-0.6	-0.4	-1.4
Arm fat mass (right)	0.5	2.1	12.4	0.5	-0.8	-0.1	0.4	0.1	-0.8	-1.3	-1.4	-2.2	-0.7	-3.5	2.0
Hair/balding pattern: Pattern 4	0.5	1.1	4.8	-0.7	-0.2	-2.0	0.6	-2.2	0.0	-0.7	-1.3	-1.3	-0.2	-0.7	-0.8
Medication: Paracetamol	0.5	0.9	3.2	1.0	0.4	0.4	-0.8	1.1	-1.0	-0.1	0.7	-0.4	-0.9	-1.8	1.6
Glaucoma (self-reported)	0.5	0.6	3.2	1.2	1.1	0.5	-0.3	0.7	0.4	1.8	0.3	0.1	0.3	-0.6	0.2
Heart disease (mother)	0.5	0.7	3.3	1.2	0.3	-0.5	0.3	-1.2	-0.6	-0.5	-0.1	-1.0	-0.6	-1.8	-0.2
Number of full sisters	0.5	0.6	3.2	0.6	0.0	-0.5	0.6	0.5	0.9	1.8	-0.9	0.1	0.8	-1.0	-0.5
Had major operations	0.5	0.6	2.1	1.4	-0.1	0.4	0.6	1.5	0.2	0.3	-0.3	0.9	0.8	-1.2	0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.5	-0.3	-0.4	0.4	-1.9	-0.5	-1.0	0.2	0.5	-0.7	-1.3	-0.8	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.9	1.6	1.7	0.1	-0.7	-0.6	0.0	0.5	0.1	-0.5	-0.4	-0.5	0.6
Osteoarthritis (self-reported)	0.5	0.7	2.4	0.4	-0.1	1.6	1.2	1.2	1.2	0.2	0.3	0.2	0.8	-0.6	0.7
Arm fat mass (left)	0.5	2.1	11.5	0.4	-0.9	-0.1	0.3	0.0	-0.8	-1.5	-1.5	-2.3	-0.8	-3.4	1.9
Mother’s age at death	0.5	0.7	2.4	0.7	0.6	0.9	0.1	1.2	0.1	-0.2	1.4	1.5	0.2	1.0	0.6
Medication: Lisinopril	0.5	0.6	1.6	-0.7	-1.0	-0.4	1.2	0.2	0.3	-0.9	-0.9	0.2	0.6	-1.3	-1.0
Basal metabolic rate	0.5	2.9	12.5	0.8	-0.7	-1.3	2.4	-1.7	-0.3	-0.8	-2.2	-2.3	0.4	-3.5	1.6
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.0	-0.7	-1.3	0.4	0.1	1.4	0.5	-1.1	-1.1	0.4	-0.1	-0.3	-0.3
Pain experienced in last month	0.5	0.9	4.0	-0.2	0.2	0.9	-2.0	0.0	-1.4	0.2	1.1	-0.1	-1.5	1.0	-0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.7	-0.4	0.0	-1.2	-0.2	-0.7	-0.4	0.3	-0.9	-1.0	-0.9	-0.8	1.3
Leg fat mass (left)	0.5	1.8	11.6	0.9	-0.8	-0.1	1.3	0.4	0.3	-0.4	-1.8	-1.6	0.2	-3.4	1.4
Fasting Glucose	0.4	0.5	2.6	-0.3	-0.0	-0.1	-1.6	0.0	-0.8	-0.7	0.9	-0.2	-0.7	-0.2	1.0
Lung FEV1/FVC ratio	0.4	1.8	6.7	1.1	0.6	-0.3	0.4	1.5	2.6	1.4	-0.0	2.6	1.8	-0.8	0.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.1	-0.6	0.2	1.4	-0.1	0.9	-0.3	-0.0	1.4	0.3	0.0	0.4	1.0
Medication: Metformin	0.4	0.5	1.9	1.4	0.6	-0.5	0.2	-0.3	0.5	1.4	0.2	-0.1	0.2	-1.3	0.7
High blood pressure	0.4	1.0	3.2	-0.1	-0.7	-1.3	1.6	-1.0	0.1	-0.1	-1.8	-0.6	0.2	-1.6	-1.2
Medication: Levothyroxine sodium	0.4	0.6	2.0	0.8	0.5	1.1	0.1	1.0	0.0	1.4	0.9	0.5	0.2	-0.5	1.2
Trunk fat mass	0.4	1.9	5.6	1.9	0.5	0.9	2.4	1.4	1.9	-0.1	-0.5	0.3	1.8	-1.6	1.4
Waist circumference	0.4	1.3	5.5	-0.3	-1.6	-0.5	0.5	0.4	-0.3	-1.1	-2.3	-1.3	-0.3	-2.2	0.4
Arm fat percentage (right)	0.4	1.5	6.8	0.4	-0.6	0.6	-0.6	1.0	-0.9	-1.5	-0.6	-1.6	-1.0	-2.6	1.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	5.7	0.2	0.0	0.9	1.6	0.5	1.2	0.3	0.7	2.4	1.8	1.3	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	2.9	-0.7	-0.6	-0.7	1.0	-0.7	0.1	-1.0	-1.7	-0.4	0.2	-0.2	-0.6
Body fat percentage	0.4	1.5	4.1	1.7	0.5	1.4	1.4	2.0	1.7	0.0	-0.1	0.5	1.3	-1.2	1.3
Medication: Ibuprofen	0.4	0.5	2.5	-0.0	0.5	-0.7	1.2	-0.9	0.4	-0.5	-1.6	-0.4	0.2	-0.1	0.0
Whole body fat mass	0.4	1.5	6.3	1.5	-0.0	0.4	1.9	0.9	1.2	-0.3	-1.1	-0.7	1.1	-2.5	1.4
Leg fat mass (right)	0.4	1.6	9.4	1.1	-0.5	0.1	1.6	0.6	0.6	-0.3	-1.6	-1.2	0.6	-3.1	1.4
Comparative height size at age 10	0.4	2.3	5.4	1.3	1.2	0.4	2.2	0.7	2.0	1.7	1.4	2.3	2.2	1.5	-0.1
Medication for cholesterol	0.4	0.7	2.4	0.7	0.8	0.6	-1.4	-0.1	-1.0	0.3	1.1	-0.1	-0.8	0.0	1.6
Wears glasses or contact lenses	0.4	0.5	2.6	0.6	-0.3	-0.8	0.4	-0.4	0.3	0.1	-1.6	-0.2	0.1	-1.0	-1.0
Medication: Paracetamol	0.4	0.6	1.9	0.9	0.2	0.5	-0.5	0.9	-1.0	-0.5	0.5	-0.5	-0.8	-1.4	1.1
Myopia	0.4	0.6	2.9	0.0	-0.1	1.2	0.2	0.4	0.1	-0.9	1.4	0.5	0.3	1.7	0.4
Vascular/heart problems diagnosed by doctor	0.4	1.1	4.9	-0.1	0.6	1.3	-1.3	0.7	-0.1	-0.3	2.0	0.6	0.0	2.2	0.5
Alzheimer’s Disease (including proxy)	0.3	0.5	1.1	1.0	0.9	0.7	0.7	0.4	0.9	0.1	0.8	0.8	0.8	0.3	0.8
Schizophrenia (2014)	0.3	0.7	2.8	1.0	1.2	0.8	0.3	0.2	0.5	1.7	0.8	0.8	0.8	-0.0	0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	-0.9	-0.9	-0.8	0.5	-0.5	0.7	-0.2	-0.8	0.1	0.3	0.1	-1.0
Blood White Count	0.3	2.4	9.9	1.4	-0.1	-2.0	2.1	1.0	1.6	1.6	-1.6	0.1	1.7	-3.1	-0.4
Cardiovascular Disease	0.3	1.2	3.7	1.6	1.3	-0.9	1.0	-0.2	1.4	1.9	0.3	0.5	0.5	-1.2	0.9
Hearing difficulty/problems: Yes	0.3	0.4	1.4	0.3	-0.7	0.5	-1.1	0.0	-0.7	0.1	-0.7	-1.2	-0.9	-0.6	-0.4
Medication: Co-codamol	0.3	0.3	1.5	-0.2	-0.8	0.3	-0.7	0.1	0.1	-0.1	-0.3	-1.2	-0.9	0.0	-0.4
Supplements: Glucosamine	0.3	0.3	1.2	-0.4	-0.3	-0.4	1.1	-0.4	0.9	0.7	-0.2	0.5	1.0	0.3	-0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.6	-0.2	-0.2	0.4	-0.5	1.3	0.2	1.0	-0.0	0.6	0.2	-0.6	-0.6
Headache pain in last month	0.3	0.4	1.3	0.6	0.5	0.5	0.4	1.0	0.6	0.2	0.4	1.2	0.5	0.5	1.1
Leg fat percentage (right)	0.3	1.2	3.7	1.2	-0.3	1.0	1.2	1.9	1.3	0.4	-0.9	-0.2	1.0	-1.9	0.9
Medication: Blood pressure	0.3	0.5	1.9	0.7	0.3	-0.7	1.2	-0.7	-0.0	-0.1	-0.6	-0.7	-0.1	-1.4	1.0
Medication: Allopurinol	0.3	0.4	1.1	0.6	-0.4	0.9	0.0	1.0	0.6	0.7	0.1	1.1	0.5	-0.1	0.2
Hypertension (Self-reported)	0.3	0.8	3.2	0.0	-0.7	-0.9	1.1	-0.7	-0.2	-0.1	-1.6	-0.6	-0.2	-1.8	-1.2
Arm fat percentage (left)	0.3	1.4	5.8	0.4	-0.4	0.5	-0.7	0.8	-0.8	-1.6	-0.7	-1.7	-1.1	-2.4	1.7
Ever had bowel cancer screening	0.3	0.3	1.9	-0.7	-0.2	-0.9	0.4	-1.4	-0.4	0.6	0.1	-0.3	0.2	0.2	-0.3
Eye problems/disorders: Cataract	0.3	0.3	1.1	-1.0	-0.3	0.4	-1.1	0.6	-0.1	0.1	0.2	0.7	-0.4	0.7	-0.2
Mineral and other dietary supplements	0.3	0.4	1.0	-0.0	-1.0	0.8	-0.8	0.8	-0.5	-0.7	-0.3	-0.2	-0.7	-0.0	-0.9
Osteoporosis (self-reported)	0.3	0.4	2.1	-0.7	-0.9	0.2	-0.6	-0.6	-1.4	-0.7	-0.2	-0.8	-0.6	0.4	0.1
Medication: Blood pressure	0.3	0.5	2.6	0.5	-0.1	-0.3	1.6	-0.1	0.4	0.4	-1.1	0.2	0.7	-0.8	-1.2
Leg fat percentage (left)	0.3	1.1	5.9	0.7	-0.9	0.6	0.6	1.5	0.7	0.1	-1.3	-0.9	0.2	-2.4	0.7
Irritability	0.3	0.6	2.3	1.4	0.2	0.2	-0.4	1.5	0.2	1.4	-0.4	0.4	0.1	-1.0	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	-0.4	-0.4	-0.2	-0.8	1.1	-0.6	-0.5	-0.3	-0.2	-0.6	-1.1	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.3	0.3	0.5	0.7	0.6	0.5	-0.2	-0.0	0.6	0.6	0.3	0.0
Primary Biliary Cirrhosis	0.2	0.3	1.2	0.4	1.1	0.2	-0.5	-0.4	-0.4	0.4	0.7	0.2	-0.2	-0.6	1.1
Average weekly fortified wine intake	0.2	0.2	1.7	0.1	-0.6	-0.1	1.3	-0.5	0.2	-0.1	0.1	-0.5	0.5	0.1	-0.2
High blood pressure (mother)	0.2	0.3	1.7	0.6	0.5	-0.1	1.1	-0.3	-0.2	0.5	-0.6	-0.1	0.2	-1.3	-0.0
Forced vital capacity (FVC)	0.2	0.6	2.8	-0.3	-0.3	0.3	1.7	-0.5	0.2	-0.5	0.6	1.2	1.1	1.0	0.4
Hair/balding pattern: Pattern 3	0.2	0.3	1.9	0.2	0.5	-0.5	-0.3	-0.6	-0.3	0.8	1.4	-0.1	-0.1	-0.5	0.6
Blood clot in the leg (DVT)	0.2	0.2	1.2	-0.4	-0.0	-0.2	-0.5	1.1	-0.1	-0.4	-0.0	0.1	-0.2	-0.6	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.4	-0.8	-0.9	0.7	-0.5	0.7	-1.2	-0.1	-0.4	-0.2	-0.9	-0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.2	-0.3	0.1	0.3	-0.4	0.7	-0.0	-0.7	0.1	0.4	-0.1	1.1	-0.1
Supplements: Vitamin C	0.2	0.3	0.9	0.2	0.5	0.3	0.8	-0.5	0.6	0.0	0.6	0.5	1.0	0.8	0.2
Illnesses of father: Heart disease	0.2	0.3	1.7	0.5	0.6	-0.4	0.8	-0.4	-0.1	0.6	0.2	-0.1	0.2	-1.3	0.5
Long-standing illness, disability or infirmity	0.2	0.2	1.0	-0.7	-0.7	0.5	0.6	0.5	0.2	-0.5	-1.0	-0.4	0.1	-0.1	-0.2
Guilty feelings	0.2	0.4	0.8	0.9	0.2	0.6	0.9	0.9	0.7	-0.2	0.2	0.0	0.8	-0.8	0.5
Schizophrenia (2018)	0.1	0.3	1.3	0.3	0.3	0.6	0.5	-0.3	0.4	1.1	0.4	0.5	0.8	-0.3	0.2
Hypothyroidism (self reported)	0.1	0.3	0.9	-0.4	-0.4	0.8	0.3	1.0	0.1	0.7	-0.0	0.6	0.1	0.8	-0.1
Tanning	0.1	1.5	4.2	-1.6	-1.7	-1.8	0.3	-1.1	-0.0	-1.6	-2.0	-1.3	-0.4	-0.6	-0.9
Supplements: Zinc	0.1	0.2	1.2	-0.2	0.1	0.6	-0.1	-0.3	-0.3	-0.0	0.4	0.1	-0.4	1.1	0.1
Medication: Ramipril	0.1	0.2	0.8	-0.1	0.1	0.1	0.0	-0.3	-0.9	-0.1	0.1	-0.6	-0.5	0.4	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.7	-0.1	-0.1	-0.2	1.1	-0.4	0.4	-0.1	0.2	1.3	1.0	0.4	0.2
Forced vital capacity (FVC), Best measure	0.1	0.4	2.4	-0.1	0.1	-0.2	1.5	-0.9	-0.0	-0.5	0.5	0.8	0.9	0.5	0.5
Hearing aid user	0.1	0.1	0.6	-0.3	0.1	-0.7	0.1	0.3	-0.1	0.2	-0.8	-0.3	-0.0	-0.5	0.3
Alcohol drinker status: Never	0.1	0.1	0.3	0.1	0.3	-0.1	-0.5	0.2	-0.3	-0.3	-0.2	0.6	-0.1	-0.2	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1
Hair Pigment	0.0	1.0	3.4	-1.6	0.4	0.1	1.2	-1.2	-0.3	-1.2	-0.8	-0.9	0.2	0.3	1.9

Hub : Genes

SEMA3B-AS1

Models

Trait associations