[Hub]/) : Traits : Neuroticism (Nagel 2018) :

chr12:108,763,672-110,729,807

Best TWAS P=2.49e-15 · Best GWAS P=4.98e-16 conditioned to 0.0301

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MMAB 0.12 0.09 enet 13 0.08 2.9e-10 7.3 -7.1 1.2e-12 -0.69 0.77 0.23 FALSE
2 GTEx Adipose Visceral Omentum MMAB 0.10 -0.01 lasso 4 0.00 3.8e-01 -5.8 -6.0 1.6e-09 -0.57 0.11 0.14 FALSE
3 GTEx Cells Transformed fibroblasts MMAB 0.07 0.06 enet 9 0.05 7.3e-05 7.3 -7.9 2.5e-15 -0.91 0.01 0.99 TRUE
4 GTEx Colon Sigmoid KCTD10 0.25 0.16 lasso 8 0.15 6.2e-06 7.0 -6.5 9.1e-11 -0.63 0.74 0.10 FALSE
5 GTEx Colon Transverse KCTD10 0.22 0.12 lasso 11 0.13 1.1e-06 -6.0 -7.1 1.4e-12 -0.72 0.35 0.65 FALSE
6 GTEx Colon Transverse MMAB 0.08 0.07 lasso 2 0.05 1.7e-03 7.0 -6.7 1.8e-11 -0.69 0.36 0.15 FALSE
7 GTEx Colon Transverse UBE3B 0.19 0.14 lasso 5 0.10 1.5e-05 5.8 -5.2 1.6e-07 -0.69 0.35 0.61 FALSE
8 GTEx Muscle Skeletal MMAB 0.06 0.04 lasso 11 0.05 1.9e-05 6.0 -5.9 4.2e-09 -0.66 0.51 0.43 FALSE
9 GTEx Nerve Tibial USP30 0.07 0.01 lasso 4 0.01 1.1e-01 5.0 6.5 8.4e-11 0.81 0.03 0.82 FALSE
10 GTEx Thyroid KCTD10 0.06 0.02 enet 12 0.02 9.2e-03 8.1 -7.0 3.2e-12 -0.85 0.01 0.98 FALSE
11 GTEx Thyroid MMAB 0.07 0.00 lasso 6 0.02 5.4e-03 -5.8 -7.4 1.1e-13 -0.77 0.09 0.77 FALSE
12 GTEx Whole Blood MVK 0.05 0.00 enet 13 0.00 4.8e-01 -5.6 -5.6 2.2e-08 -0.53 0.15 0.04 FALSE
13 YFS Blood KCTD10 0.49 0.58 enet 47 0.62 1.1e-266 6.0 6.0 2.2e-09 0.74 1.00 0.00 FALSE
14 The Cancer Genome Atlas Breast Invasive Carcinoma MMAB 0.03 0.01 blup 57 0.02 6.5e-06 7.0 -6.0 1.4e-09 -0.65 0.08 0.77 FALSE
15 The Cancer Genome Atlas Breast Invasive Carcinoma MYO1H 0.08 0.12 enet 14 0.10 1.7e-19 5.8 6.0 1.8e-09 0.72 1.00 0.00 FALSE
16 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma MMAB 0.05 0.01 blup 57 0.02 5.8e-02 5.3 -6.2 6.4e-10 -0.68 0.02 0.70 FALSE
17 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MMAB 0.03 0.02 blup 57 0.02 2.2e-03 7.5 -7.3 3.5e-13 -0.74 0.01 0.93 FALSE
18 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MMAB 0.04 0.02 blup 53 0.02 5.2e-03 7.0 -7.0 3.1e-12 -0.67 0.01 0.69 FALSE
19 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MMAB 0.09 0.05 blup 57 0.09 6.3e-06 7.0 -6.1 1.4e-09 -0.66 0.08 0.78 FALSE
20 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MVK 0.06 0.02 enet 5 0.06 2.1e-04 7.2 -6.3 3.9e-10 -0.57 0.02 0.76 FALSE
21 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MYO1H 0.05 0.02 blup 87 0.04 2.1e-03 -4.0 6.4 1.9e-10 0.85 0.06 0.54 FALSE
22 The Cancer Genome Atlas Lung Adenocarcinoma MYO1H 0.13 0.15 lasso 5 0.16 2.2e-18 5.8 5.9 3.4e-09 0.67 0.99 0.01 FALSE
23 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MMAB 0.07 0.00 blup 57 0.02 6.6e-03 3.8 -5.4 5.3e-08 -0.59 0.02 0.67 FALSE
24 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MYO1H 0.08 0.04 lasso 3 0.04 3.7e-05 -5.3 5.9 3.0e-09 0.69 0.23 0.73 FALSE
25 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MMAB 0.07 0.02 blup 57 0.03 4.5e-03 5.5 -5.5 4.0e-08 -0.59 0.05 0.32 FALSE
26 The Cancer Genome Atlas Pancreatic Adenocarcinoma MYO1H 0.19 0.09 enet 9 0.11 3.4e-05 -4.8 5.7 1.3e-08 0.61 0.16 0.74 FALSE
27 The Cancer Genome Atlas Prostate Adenocarcinoma KCTD10 0.30 0.20 enet 12 0.22 3.1e-22 -4.8 -5.1 3.1e-07 -0.50 1.00 0.00 FALSE
28 The Cancer Genome Atlas Prostate Adenocarcinoma MMAB 0.06 0.06 blup 57 0.06 5.4e-07 -6.0 -5.6 2.4e-08 -0.49 0.42 0.58 FALSE
29 The Cancer Genome Atlas Prostate Adenocarcinoma MYO1H 0.09 0.12 lasso 5 0.12 5.2e-12 -4.8 -5.7 1.2e-08 -0.61 0.99 0.01 FALSE
30 The Cancer Genome Atlas Thyroid Carcinoma KCTD10 0.15 0.08 lasso 6 0.08 2.1e-08 7.2 -7.8 5.2e-15 -0.90 0.04 0.96 FALSE