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chr12:108,763,672-110,729,807

Best TWAS P=2.49e-15 · Best GWAS P=4.98e-16 conditioned to 0.0301

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MMAB	0.12	0.09	enet	13	0.08	2.9e-10	7.3	-7.1	1.2e-12	-0.69	0.77	0.23	FALSE
2	GTEx	Adipose Visceral Omentum	MMAB	0.10	-0.01	lasso	4	0.00	3.8e-01	-5.8	-6.0	1.6e-09	-0.57	0.11	0.14	FALSE
3	GTEx	Cells Transformed fibroblasts	MMAB	0.07	0.06	enet	9	0.05	7.3e-05	7.3	-7.9	2.5e-15	-0.91	0.01	0.99	TRUE
4	GTEx	Colon Sigmoid	KCTD10	0.25	0.16	lasso	8	0.15	6.2e-06	7.0	-6.5	9.1e-11	-0.63	0.74	0.10	FALSE
5	GTEx	Colon Transverse	KCTD10	0.22	0.12	lasso	11	0.13	1.1e-06	-6.0	-7.1	1.4e-12	-0.72	0.35	0.65	FALSE
6	GTEx	Colon Transverse	MMAB	0.08	0.07	lasso	2	0.05	1.7e-03	7.0	-6.7	1.8e-11	-0.69	0.36	0.15	FALSE
7	GTEx	Colon Transverse	UBE3B	0.19	0.14	lasso	5	0.10	1.5e-05	5.8	-5.2	1.6e-07	-0.69	0.35	0.61	FALSE
8	GTEx	Muscle Skeletal	MMAB	0.06	0.04	lasso	11	0.05	1.9e-05	6.0	-5.9	4.2e-09	-0.66	0.51	0.43	FALSE
9	GTEx	Nerve Tibial	USP30	0.07	0.01	lasso	4	0.01	1.1e-01	5.0	6.5	8.4e-11	0.81	0.03	0.82	FALSE
10	GTEx	Thyroid	KCTD10	0.06	0.02	enet	12	0.02	9.2e-03	8.1	-7.0	3.2e-12	-0.85	0.01	0.98	FALSE
11	GTEx	Thyroid	MMAB	0.07	0.00	lasso	6	0.02	5.4e-03	-5.8	-7.4	1.1e-13	-0.77	0.09	0.77	FALSE
12	GTEx	Whole Blood	MVK	0.05	0.00	enet	13	0.00	4.8e-01	-5.6	-5.6	2.2e-08	-0.53	0.15	0.04	FALSE
13	YFS	Blood	KCTD10	0.49	0.58	enet	47	0.62	1.1e-266	6.0	6.0	2.2e-09	0.74	1.00	0.00	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	MMAB	0.03	0.01	blup	57	0.02	6.5e-06	7.0	-6.0	1.4e-09	-0.65	0.08	0.77	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYO1H	0.08	0.12	enet	14	0.10	1.7e-19	5.8	6.0	1.8e-09	0.72	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MMAB	0.05	0.01	blup	57	0.02	5.8e-02	5.3	-6.2	6.4e-10	-0.68	0.02	0.70	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MMAB	0.03	0.02	blup	57	0.02	2.2e-03	7.5	-7.3	3.5e-13	-0.74	0.01	0.93	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MMAB	0.04	0.02	blup	53	0.02	5.2e-03	7.0	-7.0	3.1e-12	-0.67	0.01	0.69	FALSE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MMAB	0.09	0.05	blup	57	0.09	6.3e-06	7.0	-6.1	1.4e-09	-0.66	0.08	0.78	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MVK	0.06	0.02	enet	5	0.06	2.1e-04	7.2	-6.3	3.9e-10	-0.57	0.02	0.76	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MYO1H	0.05	0.02	blup	87	0.04	2.1e-03	-4.0	6.4	1.9e-10	0.85	0.06	0.54	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	MYO1H	0.13	0.15	lasso	5	0.16	2.2e-18	5.8	5.9	3.4e-09	0.67	0.99	0.01	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MMAB	0.07	0.00	blup	57	0.02	6.6e-03	3.8	-5.4	5.3e-08	-0.59	0.02	0.67	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYO1H	0.08	0.04	lasso	3	0.04	3.7e-05	-5.3	5.9	3.0e-09	0.69	0.23	0.73	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MMAB	0.07	0.02	blup	57	0.03	4.5e-03	5.5	-5.5	4.0e-08	-0.59	0.05	0.32	FALSE
26	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MYO1H	0.19	0.09	enet	9	0.11	3.4e-05	-4.8	5.7	1.3e-08	0.61	0.16	0.74	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	KCTD10	0.30	0.20	enet	12	0.22	3.1e-22	-4.8	-5.1	3.1e-07	-0.50	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMAB	0.06	0.06	blup	57	0.06	5.4e-07	-6.0	-5.6	2.4e-08	-0.49	0.42	0.58	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYO1H	0.09	0.12	lasso	5	0.12	5.2e-12	-4.8	-5.7	1.2e-08	-0.61	0.99	0.01	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	KCTD10	0.15	0.08	lasso	6	0.08	2.1e-08	7.2	-7.8	5.2e-15	-0.90	0.04	0.96	FALSE