[Hub]/) : Traits : Neuroticism (Nagel 2018) :

chr20:43,958,786-45,456,440

Best TWAS P=1.11e-10 · Best GWAS P=6.45e-11 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Nerve Tibial CD40 0.13 0.01 lasso 5 0.02 1.4e-02 5.6 -5.9 3.2e-09 -0.80 0.02 0.94 FALSE
2 GTEx Skin Sun Exposed Lower leg CD40 0.13 0.08 lasso 3 0.08 4.1e-07 -4.7 -5.4 7.9e-08 -0.40 0.81 0.13 FALSE
3 METSIM Adipose CD40 0.07 0.04 lasso 4 0.05 3.5e-08 5.8 -6.4 1.8e-10 -0.75 0.04 0.96 FALSE
4 ROSMAP Brain Pre-frontal Cortex SLC12A5 0.24 0.24 lasso 6 0.24 5.4e-30 6.5 6.5 1.1e-10 0.98 0.00 1.00 TRUE
5 The Cancer Genome Atlas Breast Invasive Carcinoma CD40 0.06 0.05 blup 63 0.06 3.3e-12 5.8 -5.9 4.7e-09 -0.76 0.14 0.86 FALSE
6 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CD40 0.04 0.02 enet 10 0.04 2.2e-05 -4.8 -5.9 3.8e-09 -0.57 0.28 0.53 FALSE
7 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CD40 0.10 0.01 blup 63 0.09 5.8e-06 -4.7 -6.4 1.4e-10 -0.58 0.24 0.22 TRUE
8 The Cancer Genome Atlas Brain Lower Grade Glioma CD40 0.08 0.06 blup 63 0.09 4.4e-10 5.1 -5.8 5.1e-09 -0.75 0.00 1.00 FALSE
9 The Cancer Genome Atlas Thyroid Carcinoma CD40 0.03 0.00 blup 63 0.01 1.4e-02 -4.7 -5.6 2.6e-08 -0.67 0.04 0.26 FALSE