[Hub]/) : Traits : Neuroticism (Nagel 2018) :

chr22:40,472,399-42,892,596

Best TWAS P=7.17e-13 · Best GWAS P=5.15e-14 conditioned to 0.016

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TOB2 0.02 0.01 bslmm 278 0.01 3.5e-02 5.2 5.8 8.9e-09 0.66 0.48 0.16 FALSE
2 GTEx Artery Aorta L3MBTL2 0.14 0.01 lasso 6 0.04 1.8e-03 -4.4 5.9 4.8e-09 0.75 0.02 0.91 FALSE
3 GTEx Artery Aorta ACO2 0.08 0.08 lasso 5 0.06 2.8e-04 5.5 5.7 1.5e-08 0.64 0.42 0.07 FALSE
4 GTEx Brain Cerebellar Hemisphere POLR3H 0.10 0.08 lasso 7 0.08 4.9e-03 5.2 5.2 2.3e-07 0.63 0.21 0.06 FALSE
5 GTEx Brain Cortex CSDC2 0.31 0.32 lasso 5 0.28 1.8e-08 4.3 5.2 1.9e-07 0.63 1.00 0.00 FALSE
6 GTEx Brain Frontal Cortex BA9 POLR3H 0.13 0.09 lasso 7 0.04 3.4e-02 5.1 5.1 2.8e-07 0.62 0.20 0.10 FALSE
7 GTEx Brain Frontal Cortex BA9 CSDC2 0.25 0.23 lasso 8 0.24 3.8e-07 5.6 5.5 3.5e-08 0.64 0.95 0.02 FALSE
8 GTEx Brain Hippocampus POLR3H 0.16 0.11 lasso 14 0.05 2.4e-02 5.1 5.4 6.5e-08 0.64 0.19 0.10 FALSE
9 GTEx Brain Putamen basal ganglia CSDC2 0.19 0.06 lasso 4 0.13 5.3e-04 4.8 5.3 1.5e-07 0.64 0.20 0.10 FALSE
10 GTEx Cells EBV-transformed lymphocytes PMM1 0.20 0.16 lasso 7 0.14 1.9e-05 5.5 -5.3 1.4e-07 -0.62 0.83 0.02 FALSE
11 GTEx Cells EBV-transformed lymphocytes TEF 0.23 0.13 lasso 7 0.16 6.9e-06 5.5 5.6 2.4e-08 0.65 0.93 0.01 FALSE
12 GTEx Cells Transformed fibroblasts SLC25A17 0.09 0.03 enet 10 0.06 4.2e-05 7.4 7.2 7.2e-13 0.91 0.01 0.98 TRUE
13 GTEx Esophagus Gastroesophageal Junction RP4-756G23.5 0.12 0.10 lasso 4 0.08 7.7e-04 -5.7 5.2 2.1e-07 0.57 0.38 0.14 FALSE
14 GTEx Esophagus Mucosa L3MBTL2 0.16 0.11 enet 17 0.12 3.4e-08 -4.2 5.3 1.2e-07 0.64 0.87 0.11 FALSE
15 GTEx Esophagus Mucosa RANGAP1 0.07 0.02 lasso 4 0.02 8.6e-03 6.9 -6.7 2.5e-11 -0.88 0.05 0.84 FALSE
16 GTEx Esophagus Muscularis PMM1 0.07 0.05 lasso 5 0.05 6.8e-04 6.0 -5.5 4.5e-08 -0.62 0.86 0.01 FALSE
17 GTEx Heart Atrial Appendage RP4-756G23.5 0.27 0.06 lasso 6 0.04 7.0e-03 -4.3 5.6 2.4e-08 0.63 0.03 0.63 FALSE
18 GTEx Nerve Tibial ACO2 0.06 0.05 lasso 5 0.04 8.5e-04 5.5 6.3 2.3e-10 0.69 0.82 0.08 FALSE
19 GTEx Ovary ACO2 0.14 0.12 lasso 3 0.13 4.5e-04 5.2 5.5 3.0e-08 0.59 0.26 0.18 FALSE
20 GTEx Pituitary L3MBTL2 0.19 0.15 enet 17 0.19 1.6e-05 -5.7 5.9 4.8e-09 0.64 0.29 0.32 FALSE
21 GTEx Stomach DESI1 0.12 0.07 enet 14 0.06 4.9e-04 5.1 5.3 8.9e-08 0.65 0.83 0.04 FALSE
22 GTEx Testis POLR3H 0.32 0.51 enet 9 0.51 5.6e-26 5.2 5.1 2.7e-07 0.63 1.00 0.00 FALSE
23 GTEx Testis TEF 0.06 0.05 lasso 5 0.04 5.5e-03 5.4 5.7 1.2e-08 0.65 0.40 0.05 FALSE
24 GTEx Thyroid ACO2 0.08 0.09 lasso 6 0.10 9.6e-08 5.2 5.4 5.6e-08 0.66 0.99 0.01 FALSE
25 GTEx Uterus ACO2 0.13 0.06 enet 31 0.08 9.5e-03 5.6 5.6 2.3e-08 0.65 0.19 0.25 FALSE
26 NTR Blood TEF 0.01 0.02 lasso 2 0.02 3.8e-06 6.0 6.1 1.1e-09 0.63 0.97 0.01 FALSE
27 YFS Blood EP300 0.05 0.04 blup 284 0.05 5.2e-15 -2.8 5.5 4.6e-08 0.63 1.00 0.00 FALSE
28 YFS Blood MEI1 0.09 0.18 lasso 21 0.19 2.7e-59 4.7 5.4 6.8e-08 0.65 1.00 0.00 FALSE
29 YFS Blood TEF 0.09 0.17 lasso 2 0.17 9.0e-53 5.7 5.7 1.4e-08 0.65 1.00 0.00 FALSE
30 The Cancer Genome Atlas Bladder Urothelial Carcinoma PMM1 0.04 0.03 lasso 6 0.02 6.1e-03 5.2 -5.2 2.3e-07 -0.63 0.01 0.75 FALSE
31 The Cancer Genome Atlas Colon Adenocarcinoma TEF 0.04 0.03 blup 36 0.03 9.5e-03 5.6 5.8 8.2e-09 0.65 0.02 0.77 FALSE
32 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ACO2 0.03 0.01 blup 41 0.04 3.9e-03 -2.5 5.3 1.4e-07 0.65 0.02 0.58 FALSE
33 The Cancer Genome Atlas Lung Adenocarcinoma PMM1 0.02 0.03 lasso 5 0.02 1.1e-03 5.1 -5.1 2.7e-07 -0.63 0.01 0.89 FALSE
34 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TOB2 0.03 0.00 blup 28 0.02 3.4e-03 5.3 5.8 5.4e-09 0.68 0.01 0.57 FALSE
35 The Cancer Genome Atlas Skin Cutaneous Melanoma TEF 0.30 0.06 blup 36 0.09 1.8e-03 5.4 5.6 1.7e-08 0.67 0.02 0.68 FALSE
36 The Cancer Genome Atlas Stomach Adenocarcinoma RANGAP1 0.19 0.04 enet 10 0.05 2.8e-04 7.5 6.0 2.6e-09 0.86 0.00 0.92 FALSE
37 The Cancer Genome Atlas Thyroid Carcinoma L3MBTL2 0.05 0.03 enet 9 0.04 1.8e-04 7.5 7.2 8.4e-13 0.91 0.01 0.98 FALSE
38 The Cancer Genome Atlas Thyroid Carcinoma PMM1 0.09 0.11 blup 22 0.10 4.6e-10 4.7 -5.1 2.8e-07 -0.63 0.05 0.94 FALSE