[Hub]/) : Traits : Neuroticism (Nagel 2018) : ←

chr22:40,472,399-42,892,596

Best TWAS P=7.17e-13 · Best GWAS P=5.15e-14 conditioned to 0.016

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TOB2	0.02	0.01	bslmm	278	0.01	3.5e-02	5.2	5.8	8.9e-09	0.66	0.48	0.16	FALSE
2	GTEx	Artery Aorta	L3MBTL2	0.14	0.01	lasso	6	0.04	1.8e-03	-4.4	5.9	4.8e-09	0.75	0.02	0.91	FALSE
3	GTEx	Artery Aorta	ACO2	0.08	0.08	lasso	5	0.06	2.8e-04	5.5	5.7	1.5e-08	0.64	0.42	0.07	FALSE
4	GTEx	Brain Cerebellar Hemisphere	POLR3H	0.10	0.08	lasso	7	0.08	4.9e-03	5.2	5.2	2.3e-07	0.63	0.21	0.06	FALSE
5	GTEx	Brain Cortex	CSDC2	0.31	0.32	lasso	5	0.28	1.8e-08	4.3	5.2	1.9e-07	0.63	1.00	0.00	FALSE
6	GTEx	Brain Frontal Cortex BA9	POLR3H	0.13	0.09	lasso	7	0.04	3.4e-02	5.1	5.1	2.8e-07	0.62	0.20	0.10	FALSE
7	GTEx	Brain Frontal Cortex BA9	CSDC2	0.25	0.23	lasso	8	0.24	3.8e-07	5.6	5.5	3.5e-08	0.64	0.95	0.02	FALSE
8	GTEx	Brain Hippocampus	POLR3H	0.16	0.11	lasso	14	0.05	2.4e-02	5.1	5.4	6.5e-08	0.64	0.19	0.10	FALSE
9	GTEx	Brain Putamen basal ganglia	CSDC2	0.19	0.06	lasso	4	0.13	5.3e-04	4.8	5.3	1.5e-07	0.64	0.20	0.10	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	PMM1	0.20	0.16	lasso	7	0.14	1.9e-05	5.5	-5.3	1.4e-07	-0.62	0.83	0.02	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	TEF	0.23	0.13	lasso	7	0.16	6.9e-06	5.5	5.6	2.4e-08	0.65	0.93	0.01	FALSE
12	GTEx	Cells Transformed fibroblasts	SLC25A17	0.09	0.03	enet	10	0.06	4.2e-05	7.4	7.2	7.2e-13	0.91	0.01	0.98	TRUE
13	GTEx	Esophagus Gastroesophageal Junction	RP4-756G23.5	0.12	0.10	lasso	4	0.08	7.7e-04	-5.7	5.2	2.1e-07	0.57	0.38	0.14	FALSE
14	GTEx	Esophagus Mucosa	L3MBTL2	0.16	0.11	enet	17	0.12	3.4e-08	-4.2	5.3	1.2e-07	0.64	0.87	0.11	FALSE
15	GTEx	Esophagus Mucosa	RANGAP1	0.07	0.02	lasso	4	0.02	8.6e-03	6.9	-6.7	2.5e-11	-0.88	0.05	0.84	FALSE
16	GTEx	Esophagus Muscularis	PMM1	0.07	0.05	lasso	5	0.05	6.8e-04	6.0	-5.5	4.5e-08	-0.62	0.86	0.01	FALSE
17	GTEx	Heart Atrial Appendage	RP4-756G23.5	0.27	0.06	lasso	6	0.04	7.0e-03	-4.3	5.6	2.4e-08	0.63	0.03	0.63	FALSE
18	GTEx	Nerve Tibial	ACO2	0.06	0.05	lasso	5	0.04	8.5e-04	5.5	6.3	2.3e-10	0.69	0.82	0.08	FALSE
19	GTEx	Ovary	ACO2	0.14	0.12	lasso	3	0.13	4.5e-04	5.2	5.5	3.0e-08	0.59	0.26	0.18	FALSE
20	GTEx	Pituitary	L3MBTL2	0.19	0.15	enet	17	0.19	1.6e-05	-5.7	5.9	4.8e-09	0.64	0.29	0.32	FALSE
21	GTEx	Stomach	DESI1	0.12	0.07	enet	14	0.06	4.9e-04	5.1	5.3	8.9e-08	0.65	0.83	0.04	FALSE
22	GTEx	Testis	POLR3H	0.32	0.51	enet	9	0.51	5.6e-26	5.2	5.1	2.7e-07	0.63	1.00	0.00	FALSE
23	GTEx	Testis	TEF	0.06	0.05	lasso	5	0.04	5.5e-03	5.4	5.7	1.2e-08	0.65	0.40	0.05	FALSE
24	GTEx	Thyroid	ACO2	0.08	0.09	lasso	6	0.10	9.6e-08	5.2	5.4	5.6e-08	0.66	0.99	0.01	FALSE
25	GTEx	Uterus	ACO2	0.13	0.06	enet	31	0.08	9.5e-03	5.6	5.6	2.3e-08	0.65	0.19	0.25	FALSE
26	NTR	Blood	TEF	0.01	0.02	lasso	2	0.02	3.8e-06	6.0	6.1	1.1e-09	0.63	0.97	0.01	FALSE
27	YFS	Blood	EP300	0.05	0.04	blup	284	0.05	5.2e-15	-2.8	5.5	4.6e-08	0.63	1.00	0.00	FALSE
28	YFS	Blood	MEI1	0.09	0.18	lasso	21	0.19	2.7e-59	4.7	5.4	6.8e-08	0.65	1.00	0.00	FALSE
29	YFS	Blood	TEF	0.09	0.17	lasso	2	0.17	9.0e-53	5.7	5.7	1.4e-08	0.65	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PMM1	0.04	0.03	lasso	6	0.02	6.1e-03	5.2	-5.2	2.3e-07	-0.63	0.01	0.75	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	TEF	0.04	0.03	blup	36	0.03	9.5e-03	5.6	5.8	8.2e-09	0.65	0.02	0.77	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ACO2	0.03	0.01	blup	41	0.04	3.9e-03	-2.5	5.3	1.4e-07	0.65	0.02	0.58	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	PMM1	0.02	0.03	lasso	5	0.02	1.1e-03	5.1	-5.1	2.7e-07	-0.63	0.01	0.89	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TOB2	0.03	0.00	blup	28	0.02	3.4e-03	5.3	5.8	5.4e-09	0.68	0.01	0.57	FALSE
35	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TEF	0.30	0.06	blup	36	0.09	1.8e-03	5.4	5.6	1.7e-08	0.67	0.02	0.68	FALSE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	RANGAP1	0.19	0.04	enet	10	0.05	2.8e-04	7.5	6.0	2.6e-09	0.86	0.00	0.92	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	L3MBTL2	0.05	0.03	enet	9	0.04	1.8e-04	7.5	7.2	8.4e-13	0.91	0.01	0.98	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	PMM1	0.09	0.11	blup	22	0.10	4.6e-10	4.7	-5.1	2.8e-07	-0.63	0.05	0.94	FALSE