Best TWAS P=1.65e-22 · Best GWAS P=1.43e-23 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | IFT80 | 0.08 | 0.06 | enet | 35 | 0.06 | 1.5e-07 | 4.0 | -9.3 | 1.2e-20 | 0.57 | 0.96 | 0.04 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | IL12A | 0.05 | 0.03 | enet | 16 | 0.02 | 4.3e-04 | -10.0 | -6.2 | 5.6e-10 | 0.78 | 0.00 | 0.99 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | TRIM59 | 0.03 | 0.01 | blup | 379 | 0.01 | 3.1e-02 | 4.3 | -6.7 | 2.0e-11 | 0.36 | 0.57 | 0.06 | TRUE |
| 4 | GTEx | Brain Cortex | IFT80 | 0.15 | 0.09 | lasso | 3 | 0.04 | 2.5e-02 | -5.8 | -7.4 | 1.8e-13 | 0.34 | 0.27 | 0.08 | FALSE |
| 5 | GTEx | Testis | KPNA4 | 0.14 | 0.04 | enet | 21 | 0.06 | 1.7e-03 | -5.1 | -7.2 | 4.4e-13 | 0.40 | 0.56 | 0.13 | TRUE |
| 6 | YFS | Blood | KPNA4 | 0.02 | 0.02 | lasso | 6 | 0.01 | 6.7e-05 | -5.4 | -5.3 | 1.1e-07 | 0.23 | 0.58 | 0.02 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRIM59 | 0.01 | 0.01 | blup | 41 | 0.01 | 7.8e-04 | -5.8 | -5.9 | 4.6e-09 | 0.24 | 0.01 | 0.96 | TRUE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SMC4 | 0.04 | 0.03 | lasso | 3 | 0.02 | 9.9e-04 | -5.8 | -5.4 | 8.7e-08 | 0.21 | 0.00 | 0.98 | TRUE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IFT80 | 0.03 | 0.02 | blup | 94 | 0.02 | 3.1e-03 | -5.8 | -5.3 | 1.4e-07 | 0.21 | 0.01 | 0.97 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IL12A | 0.08 | 0.07 | enet | 14 | 0.07 | 1.1e-08 | -9.8 | -9.8 | 1.7e-22 | 0.88 | 0.01 | 0.99 | TRUE |
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL12A | 0.05 | 0.01 | enet | 17 | 0.02 | 6.0e-03 | -5.5 | 7.3 | 2.0e-13 | -0.53 | 0.02 | 0.37 | TRUE |