TWAS hub - IL12A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0540	0.0250	8.7e-03	0.035	0.014	0.025	0.025	0.024	3.8e-05	7.0e-03	4.3e-04	0.00049	5.9e-04
2	TCGA	Brain Lower Grade Glioma	0.0791	0.0305	2.3e-08	0.073	0.067	0.073	NA	0.071	1.1e-08	4.9e-08	1.1e-08	NA	1.7e-08
3	TCGA	Lung Squamous Cell Carcinoma	0.0483	0.0304	7.0e-03	0.012	0.010	0.016	NA	0.012	1.4e-02	2.4e-02	6.0e-03	NA	1.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Primary Biliary Cirrhosis	43.9	62.6	95.3	-6.2	-9.8	7.3
Mouth/teeth dental problems: Mouth ulcers	20.7	32.9	66.1	4.7	8.1	-3.3
Lupus	7.1	10.8	16.4	-3.9	-4.0	0.8
Body Mass Index (BMI) (2010)	4.7	6.5	10.6	1.3	3.3	-2.6
Medication: Omeprazole	4.3	5.2	7.6	-2.8	-1.7	2.3
Medication: Gliclazide	3.9	4.4	5.2	1.8	2.1	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	3.7	8.4	11.1	2.0	3.2	-3.3
Comparative body size at age 10	3.7	10.2	10.8	3.1	3.2	-3.3
Pain experienced in last month	3.6	6.0	9.2	-0.9	-3.0	2.8
Rheumatoid Arthritis	3.3	4.5	7.1	-1.6	-2.7	2.0
Falls in the last year	3.3	4.5	5.7	2.1	2.4	-1.8
Medication: Omeprazole (e.g. Zanprol)	3.1	3.7	5.9	-2.4	-1.4	1.9
Hypothyroidism (self reported)	2.9	6.8	15.7	-1.0	-4.0	1.9
Hypothyroidism/myxoedema (self-reported)	2.6	5.1	12.1	-1.4	-3.5	1.1
Leg pain on walking	2.6	3.3	7.1	0.3	2.7	-1.6
Ever had prostate specific antigen (PSA) test	2.6	3.0	6.6	-0.1	2.6	-1.5
Had menopause	2.5	3.1	4.2	-1.3	-2.0	1.8
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.1	8.1	1.0	2.9	-2.5
Number of children fathered	2.3	2.6	4.7	1.3	2.2	-1.2
Alcohol drinker status: Never	2.3	2.8	4.6	2.1	0.7	-1.8
Impedance of arm (right)	2.2	10.4	10.6	-3.3	-3.2	3.2
Irritability	2.2	3.8	10.0	-3.2	-0.6	1.0
Serious illness, injury or assault to yourself	2.1	2.6	4.1	0.2	1.9	-2.0
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	6.9	0.5	2.6	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	5.5	-2.3	-0.3	1.3
Prostate Cancer	2.0	2.8	6.3	0.5	1.3	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	5.2	0.3	1.1	-2.3
Ever depressed for a whole week	2.0	2.5	4.1	-1.8	-2.0	0.3
Bilateral oophorectomy (both ovaries removed)	1.9	2.3	5.1	2.3	0.2	-1.3
Hayfever, allergic rhinitis or eczema	1.9	4.1	5.2	1.5	2.2	-2.3
Pulse wave reflection index	1.9	2.3	6.0	2.4	1.0	-0.0
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	3.1	-1.8	-1.5	1.3
High cholesterol (Self-reported)	1.9	3.3	4.6	-1.6	-2.1	1.7
Impedance of whole body	1.9	9.8	10.2	-3.0	-3.2	3.2
Body mass index (BMI)	1.8	7.7	10.1	3.2	2.3	-2.8
Impedance of arm (left)	1.8	8.4	9.1	-3.0	-2.7	3.0
Knee pain experienced in last month	1.8	2.8	4.8	1.1	1.6	-2.2
Eye problems/disorders: Cataract	1.8	2.0	5.1	0.6	0.9	-2.3
Sensitivity / hurt feelings	1.7	2.9	7.7	-2.8	-0.6	0.8
Impedance of leg (right)	1.7	8.3	11.8	-2.4	-3.4	2.7
Worry too long after embarrassment	1.7	2.8	8.2	-2.9	-0.3	0.3
Qualifications: College or University degree	1.7	5.4	10.8	1.9	3.3	-1.3
Wears glasses or contact lenses	1.7	2.0	2.1	-1.5	-1.4	1.4
Neuroticism	1.6	3.9	10.7	-3.3	-0.2	1.0
Age at first live birth	1.6	2.8	3.2	1.7	1.8	-1.5
Shortness of breath walking on level ground	1.6	1.9	3.5	0.4	1.4	-1.9
Number of self-reported non-cancer illnesses	1.6	2.7	5.7	-2.4	-1.3	0.9
Triglycerides	1.5	2.5	3.4	-1.0	-1.9	1.7
BMI	1.5	8.8	16.8	4.1	2.2	-2.2
Chronotype (morning person)	1.5	3.4	6.7	-0.6	-2.6	1.8
Average weekly spirits intake	1.5	1.8	2.5	-0.8	1.5	-1.6
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	2.6	-1.4	-1.6	1.0
Mouth/teeth dental problems	1.5	2.4	6.3	-0.8	-2.5	0.1
Weight	1.5	7.1	8.4	2.9	2.4	-2.7
Depression (self-reported)	1.5	1.8	4.5	-2.1	-0.2	-0.9
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	5.3	2.3	1.1	-0.8
Back pain experienced in last month	1.5	2.1	3.0	1.2	1.4	-1.7
Arm fat mass (left)	1.5	6.0	8.6	2.9	1.9	-2.4
Arm fat-free mass (left)	1.5	7.5	8.2	2.9	2.7	-2.6
Arm predicted mass (left)	1.5	7.7	10.0	3.2	2.5	-2.6
Breast Cancer	1.4	3.3	4.5	2.1	2.0	-1.2
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.8	-1.1	-1.9	0.8
Impedance of leg (left)	1.4	6.6	10.0	-2.1	-3.2	2.4
Past tobacco smoking	1.4	2.6	6.8	2.6	0.3	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.7	3.4	1.0	1.8	-0.8
Pulse wave Arterial Stiffness index	1.4	1.6	3.8	1.9	-0.4	1.0
Migraine (self-reported)	1.4	1.7	2.9	-1.7	0.1	-1.5
Arm predicted mass (right)	1.4	7.4	8.8	3.0	2.7	-2.4
Depression (Nagel 2018)	1.3	2.0	3.6	-1.9	-1.2	1.0
Heel T-Score	1.3	10.2	15.6	2.1	4.0	-3.2
Stomach or abdominal pain in last month	1.3	1.6	2.9	0.3	1.3	-1.7
Waist circumference	1.3	4.9	6.5	2.6	1.9	-2.1
Allergy	1.3	3.0	3.9	-1.6	-1.6	2.0
Arm fat mass (right)	1.3	5.4	8.9	3.0	1.7	-2.1
Arm fat-free mass (right)	1.3	6.8	7.7	2.8	2.7	-2.4
Leg fat-free mass (right)	1.3	6.9	8.4	2.7	2.9	-2.3
Leg predicted mass (right)	1.3	6.9	8.5	2.7	2.9	-2.3
Eye problems/disorders: Glaucoma	1.3	1.6	2.2	-0.9	-1.5	1.2
Basal metabolic rate	1.3	7.1	8.2	2.9	2.7	-2.5
Leg fat mass (left)	1.3	5.2	8.9	3.0	1.5	-2.1
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.3	-1.5	-1.2	0.6
Vitamin and mineral supplements	1.2	1.7	3.8	-0.8	-2.0	0.8
Leg fat-free mass (left)	1.2	6.2	7.3	2.7	2.6	-2.1
Medication: Levothyroxine sodium	1.2	2.0	5.4	-0.4	-2.3	0.6
Leg predicted mass (left)	1.2	6.2	7.0	2.6	2.6	-2.2
Hip circumference	1.2	5.0	6.4	2.5	1.9	-2.3
Pulse wave peak to peak time	1.2	1.4	2.9	-1.7	0.6	-1.0
Medication for pain relief, constipation, heartburn	1.2	2.1	3.8	2.0	1.1	-1.1
Whole body fat mass	1.2	5.1	7.8	2.8	1.8	-2.1
Leg fat mass (right)	1.2	4.8	8.5	2.9	1.5	-1.9
Suffer from ‘nerves’	1.2	1.9	2.9	-0.7	-1.6	1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	4.7	0.8	1.4	-2.2
Commuting to job workplace: Walk	1.2	1.3	3.0	-1.7	-0.8	-0.3
Whole body water mass	1.2	7.1	8.0	2.8	2.7	-2.5
Mean Putamen Volume	1.1	1.3	2.6	-1.6	-0.9	-0.7
Diabetes (father)	1.1	1.4	1.7	-1.2	-1.1	1.3
Relative age voice broke	1.1	1.7	2.8	-0.7	-1.4	1.7
Medication: Simvastatin	1.1	1.7	3.6	-1.0	-1.9	0.7
Trunk fat-free mass	1.1	6.0	6.4	2.5	2.5	-2.3
Alcohol intake versus 10 years previously	1.1	1.7	3.7	-0.7	-0.9	1.9
Trunk predicted mass	1.1	6.1	6.4	2.5	2.5	-2.4
Number of full brothers	1.1	1.4	1.8	1.0	1.3	-1.2
Wheeze or whistling in the chest in last year	1.1	2.0	3.6	0.1	1.9	-1.5
Whole body fat-free mass	1.1	6.5	7.4	2.7	2.6	-2.3
Basal cell carcinoma (self-reported)	1.1	1.3	2.0	-0.9	-0.9	1.4
Fasting Glucose	1.0	1.2	2.9	1.7	0.9	-0.2
Financial difficulties in last 2 years	1.0	1.4	2.5	0.7	1.6	-1.1
Pain all over the body in last month	1.0	1.0	2.0	-0.3	1.4	-1.0
Neuroticism score	1.0	2.1	5.7	-2.4	-0.2	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.5	3.8	-2.0	-0.1	0.9
Heart disease (mother)	1.0	1.3	3.5	1.9	0.4	0.3
Medication: Lisinopril	1.0	1.4	2.0	-0.4	-1.4	1.4
Neuroticism (Nagel 2018)	0.9	2.0	5.6	-2.4	-0.5	0.4
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.2	-1.8	-0.6	0.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.3	0.4	1.1	-1.5
Medication: Metformin	0.9	1.2	2.1	0.3	1.4	-1.2
Time employed in main current job	0.9	1.1	2.8	1.7	0.2	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.1	-1.8	-0.2	0.4
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.1	-0.8	-1.5	0.5
Guilty feelings	0.9	1.3	2.3	-1.5	0.2	-1.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.7	-0.2	0.1	-1.6
Taking other prescription medications	0.8	1.3	3.3	-1.8	-0.7	-0.1
Chronic bronchitis/emphysema (father)	0.8	0.9	2.4	-1.5	-0.5	0.3
Trunk fat mass	0.8	3.5	5.2	2.3	1.5	-1.8
Had other major operations	0.8	1.0	2.5	0.4	0.6	-1.6
Lung cancer (father)	0.8	1.0	1.3	-1.1	-0.9	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.3	-1.1	0.7	-1.1
Health satisfaction	0.8	1.1	1.8	0.6	1.3	-1.1
Eye problems/disorders: None of the above	0.8	0.9	2.6	0.5	0.2	1.6
Medication: Seretide 50 evohaler	0.8	1.0	2.8	-1.7	0.3	0.1
Medication: Bendroflumethiazide	0.8	1.2	2.2	0.7	1.0	-1.5
Leg fat percentage (left)	0.8	3.0	5.2	2.3	0.7	-1.8
Supplements: Calcium	0.8	0.9	1.5	-1.2	0.7	-0.8
Pack years of smoking	0.8	1.2	2.0	-0.7	-1.4	1.1
Ulcerative Colitis	0.7	1.1	2.1	1.4	0.9	0.6
Allergy or Eczema	0.7	1.9	4.0	2.0	0.5	-1.2
High blood pressure	0.7	2.1	3.2	-1.2	-1.8	1.3
Nervous feelings	0.7	1.4	1.6	-1.3	-1.1	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.4	-0.5	-1.5	0.8
Medication: Ramipril	0.7	0.9	1.3	-0.9	-1.1	-0.8
Asthma	0.7	1.3	1.7	1.3	0.9	-1.2
Length of working week for main job	0.7	0.8	2.2	0.4	0.2	-1.5
Leg fat percentage (right)	0.7	2.6	4.5	2.1	0.7	-1.7
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.6	-0.1	1.3	-1.0
Number of full sisters	0.7	0.9	1.6	-0.4	0.9	-1.3
Smoking status: Previous	0.7	1.0	2.7	-1.6	0.0	0.5
Qualifications: nursing, teaching	0.7	1.0	1.8	0.9	1.3	-0.6
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.5	-0.6	-1.2	1.9
Alzheimer’s Disease (in mother)	0.6	0.7	1.8	-0.4	0.5	-1.4
Ever had hysterectomy (womb removed)	0.6	0.6	1.7	1.3	0.0	-0.5
Severe depression (siblings)	0.6	0.6	1.0	-1.0	0.6	-0.8
Fed-up feelings	0.6	1.1	2.5	-1.6	-0.9	0.4
Supplements: Glucosamine	0.6	0.8	2.0	-1.4	0.2	-0.7
Alcohol usually taken with meals	0.6	0.9	1.8	1.3	1.0	-0.2
Hearing difficulty/problems with background noise	0.6	1.0	1.8	1.0	1.4	-0.5
Arm fat percentage (right)	0.6	2.5	5.1	2.3	0.7	-1.4
Father’s age at death	0.6	0.8	1.4	1.2	-0.8	0.6
Pulse rate	0.6	1.0	1.5	-1.2	-1.2	0.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.1	1.2	1.4	-0.7
Medication: Cholesterol lowering	0.6	0.9	1.4	-1.2	-1.1	-0.0
Prospective memory result	0.6	0.7	1.8	-0.4	-0.4	-1.3
Illnesses of mother	0.6	0.8	1.6	-0.5	1.3	-0.7
Body fat percentage	0.6	2.4	4.5	2.1	0.9	-1.4
Exposure to tobacco smoke outside home	0.6	0.8	1.4	0.6	0.8	1.2
Neck or shoulder pain in last month	0.6	0.8	2.2	-1.5	-0.3	0.4
Illnesses of father: Heart disease	0.6	0.9	2.5	-1.6	-0.3	-0.4
Arm fat percentage (left)	0.6	2.4	4.5	2.1	0.9	-1.3
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.8	-0.5	-1.3	-0.1
Asthma (self-reported)	0.6	1.2	1.5	1.2	0.8	-1.2
Osteoarthritis (self-reported)	0.6	0.8	2.1	-0.3	0.4	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	2.0	-0.4	1.4	-1.4
Major Depression (MDD)	0.5	0.6	1.8	-1.3	-0.4	0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	1.4	-1.0	-1.1	1.2
Coronary Artery Disease (CAD)	0.5	0.6	1.6	-0.3	-1.3	0.4
HDL Cholesterol	0.5	0.9	1.6	-1.3	-0.8	0.6
LDL Cholesterol	0.5	0.8	0.9	-0.7	-1.0	0.9
Neuroticism (2016)	0.5	0.7	1.3	-1.1	1.0	0.0
Respiratory disease	0.5	1.1	2.3	1.5	0.1	-1.0
Number of treatments/medications taken	0.5	0.9	2.5	-1.6	-0.5	0.0
Medication for hormone replacement therapy	0.5	0.6	1.0	-0.2	-0.8	1.0
Supplements: Zinc	0.5	0.5	0.9	-0.7	-0.2	1.0
Medication: Co-codamol	0.5	0.5	1.3	-0.6	-0.0	-1.1
Qualifications: CSEs or equivalent	0.5	0.7	1.7	0.2	-1.3	0.6
Hair/balding pattern: Pattern 3	0.5	0.7	0.9	0.7	0.9	-0.9
Medication: Lansoprazole	0.5	0.6	1.0	-0.7	-0.4	1.0
Birth weight of first child	0.5	0.9	1.3	-0.6	-1.0	1.1
Medication: Ibuprofen	0.5	0.6	1.9	-1.4	0.1	-0.0
Had major operations	0.5	0.6	0.7	0.5	0.8	-0.8
Friendships satisfaction	0.5	0.7	1.3	-0.8	0.1	1.1
Osteoporosis (self-reported)	0.5	0.6	1.1	-1.0	0.2	-0.8
Alcohol drinker status: Previous	0.5	0.6	1.0	-1.0	-0.4	-0.8
Bipolar Disorder (2018)	0.4	0.6	0.8	-0.7	0.9	-0.7
Worry (Nagel 2018)	0.4	0.8	1.9	-1.4	-0.5	0.3
Alzheimer’s Disease (in father)	0.4	0.5	1.0	1.0	0.4	0.5
Reaction Time	0.4	0.7	1.4	-0.8	0.3	-1.2
Cardiovascular Disease	0.4	1.4	2.6	-1.1	-1.6	0.8
Diabetes (mother)	0.4	0.5	0.8	0.1	0.9	0.9
Pack years adult smoking proportion	0.4	0.7	1.2	-0.5	-1.1	0.7
Trunk fat percentage	0.4	1.8	3.4	1.8	0.8	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.3	-1.1	-0.1	0.6
Heart attack	0.4	0.5	1.3	-0.0	0.4	-1.1
Fluid intelligence score	0.4	0.8	1.2	-1.1	-0.4	1.0
Number of live births	0.4	0.5	1.0	-1.0	-0.5	0.6
Happiness	0.4	0.5	0.7	-0.3	0.7	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.7	-0.5	1.1	-1.6
Breastfed as a baby	0.4	0.5	1.3	0.3	-1.2	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.6	-1.3	-0.1	-0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	1.0	0.3	-0.5
Angina (self-reported)	0.4	0.6	1.3	1.1	-0.3	-0.5
Age at last live birth	0.4	0.5	1.3	0.3	1.1	-0.5
Family relationship satisfaction	0.4	0.5	1.5	0.1	1.2	0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.1	-0.3	0.1	1.1
Hypertension (Self-reported)	0.4	1.2	1.5	-0.8	-1.2	1.2
Loneliness, isolation	0.4	0.6	1.6	0.3	0.2	1.3
Long-standing illness, disability or infirmity	0.4	0.6	1.6	-1.3	0.3	-0.5
Medication for cholesterol	0.4	0.6	1.6	-0.4	1.3	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.7	-0.8	-0.8	-0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	1.2	0.1	-0.5
Miserableness	0.4	0.7	1.4	-0.4	1.2	-0.7
Ever taken oral contraceptive pill	0.4	0.4	0.8	-0.5	-0.3	0.9
Ever smoked	0.4	0.8	2.2	-1.5	0.4	0.2
Number of operations (self-reported)	0.4	0.6	1.1	0.8	0.3	-1.0
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.5	-0.1	0.4	-1.2
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	0.6	0.8	-0.5
Crohns Disease (2017)	0.3	0.6	1.2	-0.7	-1.1	0.1
Ulcerative Colitis (UC)	0.3	0.5	0.7	0.9	0.5	0.7
Ovarian Cancer	0.3	0.4	0.7	-0.7	-0.8	-0.2
HbA1C	0.3	0.3	0.9	0.9	0.1	-0.4
Blood Platelet Count	0.3	3.1	4.8	0.2	-2.1	2.2
Smoking Status	0.3	0.7	1.3	-1.1	0.6	-0.6
Hand grip strength (left)	0.3	0.7	1.1	0.9	1.1	0.2
Hearing difficulty/problems: Yes	0.3	0.5	0.8	0.9	0.2	-0.8
Relative age of first facial hair	0.3	0.6	1.3	-1.1	0.2	-0.7
Angina	0.3	0.4	0.9	0.9	-0.4	-0.4
Maternal smoking around birth	0.3	0.4	0.6	-0.7	-0.7	0.3
Multivitamins +/- minerals	0.3	0.4	1.2	-0.1	1.1	0.1
Medication: Atenolol	0.3	0.3	0.6	0.5	-0.8	0.5
Number of incorrect matches in round	0.3	0.5	1.1	0.4	-0.5	1.0
Qualifications: None of the above	0.3	0.7	1.4	-1.2	-0.8	0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	-0.3	0.1	1.1
Peak expiratory flow (PEF)	0.3	0.7	1.0	0.3	1.0	-1.0
Medication: Paracetamol	0.3	0.4	0.9	-0.9	0.5	0.3
Headache pain in last month	0.3	0.6	0.8	-0.8	0.9	-0.6
Medication: Amlodipine	0.3	0.5	0.8	-0.4	-0.7	0.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.8	-0.9	-0.6	-0.2
Forced vital capacity (FVC), Best measure	0.3	0.9	2.2	-0.2	0.8	-1.5
Emphysema/chronic bronchitis	0.3	0.4	0.6	-0.6	-0.8	0.4
Mean time to correctly identify matches	0.3	0.6	1.4	-1.2	-0.4	-0.5
Comparative height size at age 10	0.3	1.8	2.3	0.9	1.4	-1.5
Supplements: Vitamin C	0.3	0.3	0.5	-0.7	-0.6	0.4
Average weekly red wine intake	0.3	0.4	1.3	0.0	-1.1	0.2
Mood swings	0.3	0.5	1.0	-1.0	0.2	-0.7
Medication: Aspirin	0.3	0.3	0.5	0.7	0.7	-0.0
Mother’s age at death	0.3	0.4	0.6	-0.7	0.2	0.8
Financial situation satisfaction	0.3	0.4	1.1	-0.3	1.0	-0.0
Commuting to job workplace: Public transport	0.3	0.4	1.1	0.2	-0.3	-1.0
Medication: Atorvastatin	0.3	0.4	0.9	-0.5	-1.0	0.4
Average weekly beer plus cider intake	0.3	0.4	1.1	1.0	-0.3	-0.4
Unable to work because of sickness or disability	0.3	0.4	1.0	-0.3	-0.0	1.0
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.0	0.4	1.4	-0.7
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	-1.0	-0.2	0.5
Crohns Disease (2012)	0.2	0.3	0.7	-0.4	-0.8	-0.2
Blood Red Count	0.2	1.5	3.0	1.7	1.2	0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	0.4	0.5	-0.8
Lung FVC	0.2	1.1	1.8	-1.4	-1.3	0.2
Systolic blood pressure, automated reading	0.2	0.6	1.3	0.2	-1.1	0.6
Hand grip strength (right)	0.2	0.6	0.9	0.9	0.9	0.2
Townsend deprivation index at recruitment	0.2	0.3	0.4	0.3	0.6	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.4	0.6	-0.0
High blood pressure (mother)	0.2	0.3	0.6	-0.3	-0.8	0.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	0.3	0.7	0.2
Worrier / anxious feelings	0.2	0.4	0.8	-0.9	0.5	-0.2
Exposure to tobacco smoke at home	0.2	0.2	0.3	-0.4	-0.6	0.4
Tense / ‘highly strung’	0.2	0.3	0.5	-0.7	0.1	-0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	0.8	0.6	0.0
Birth weight	0.2	0.5	1.4	-1.2	0.2	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	-0.0	-0.7	-0.1
Medication: Allopurinol	0.2	0.3	0.9	-0.9	-0.0	-0.2
Overall health rating	0.2	0.5	0.6	-0.8	0.6	-0.7
Medication: Aspirin	0.2	0.3	0.5	0.7	0.6	0.3
Illnesses of siblings: Diabetes	0.2	0.2	0.3	-0.0	-0.6	0.6
Ever had bowel cancer screening	0.2	0.3	0.4	-0.6	-0.0	0.6
Breast cancer (self-reported)	0.2	0.2	0.5	-0.0	0.7	-0.5
Smoking status: Current	0.2	0.3	0.4	-0.6	0.6	-0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.7	0.5	0.9	-0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.5	-0.0	-0.6
Illnesses of father: High blood pressure	0.2	0.3	0.5	-0.1	0.7	-0.6
Risk taking	0.2	0.2	0.7	-0.8	0.2	0.1
Age started oral contraceptive pill	0.2	0.3	0.4	0.6	0.6	-0.4
Commuting to job workplace: Cycle	0.2	0.2	0.5	-0.7	-0.2	-0.3
Myopia	0.2	0.3	0.8	0.3	-0.3	0.9
Cholesterol lowering medication	0.2	0.2	0.6	0.2	-0.8	0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	-0.6	0.5	0.0
Schizophrenia (2018)	0.1	0.1	0.3	-0.2	-0.2	0.6
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	-0.1	-0.5	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	0.1	-0.4	0.5
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.3	-0.1	0.5
Blood Eosinophil Count	0.1	1.1	2.1	1.4	-0.9	-0.7
Blood White Count	0.1	0.4	0.9	0.6	1.0	0.0
Waist Hip Ratio (WHR)	0.1	0.5	1.2	0.6	1.1	0.1
Systolic Blood Pressure	0.1	0.4	0.8	0.9	-0.5	0.4
Hair Pigment	0.1	1.9	3.6	0.7	1.9	-1.3
Current tobacco smoking	0.1	0.2	0.5	-0.7	0.3	0.1
Average weekly fortified wine intake	0.1	0.1	0.1	0.4	0.3	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	-0.4	-0.5	-0.3
Sitting height	0.1	0.7	1.3	-0.3	1.1	-0.8
Diabetes (self-reported)	0.1	0.1	0.1	0.3	-0.3	-0.3
Illnesses of siblings	0.1	0.1	0.1	0.4	0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.7	-0.3	0.8	-0.9
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	0.7	0.0	0.5
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.3	0.3	-0.4
Glaucoma (self-reported)	0.1	0.1	0.1	-0.3	-0.3	0.2
Gout (self-reported)	0.1	0.1	0.2	-0.5	-0.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	-0.0	-0.6	0.2
Alcohol intake frequency.	0.1	0.2	0.7	0.1	-0.9	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.5	0.1	-0.2
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.2	-0.0	-0.7
Mineral and other dietary supplements	0.1	0.2	0.5	0.1	-0.3	0.7
Hearing aid user	0.1	0.1	0.1	-0.2	-0.4	0.3
Medication: Blood pressure	0.1	0.3	0.7	0.0	-0.9	-0.2
Medication: Paracetamol	0.1	0.2	0.3	-0.6	0.6	0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.5	-0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.0	0.3	-0.6
Heart disease (siblings)	0.1	0.1	0.3	0.5	0.4	0.0
Age at First Birth	0.0	0.0	0.0	-0.1	0.2	-0.2
Schizophrenia (2014)	0.0	0.1	0.2	-0.4	0.1	0.0
Height	0.0	0.1	0.2	0.2	0.5	0.3
Lung FEV1/FVC ratio	0.0	0.2	0.4	-0.4	0.7	-0.2
Tanning	0.0	0.4	1.0	0.4	1.0	-0.1
Age when periods started (menarche)	0.0	0.0	0.1	0.2	0.3	0.0
Forced vital capacity (FVC)	0.0	0.1	0.2	-0.4	0.2	-0.3
Noisy workplace	0.0	0.1	0.1	0.2	-0.1	0.3
Standing height	0.0	0.1	0.4	0.0	0.7	-0.0
Loud music exposure frequency	0.0	0.0	0.0	0.2	-0.1	0.0
High blood pressure (siblings)	0.0	0.1	0.1	-0.3	-0.2	0.1
Medication: Blood pressure	0.0	0.0	0.1	0.1	0.3	-0.1
Pulse rate, automated reading	0.0	0.1	0.2	-0.4	0.1	0.4
Chest pain or discomfort	0.0	0.1	0.2	-0.4	-0.1	0.0
Illness, injury, bereavement, stress in last 2 years	0.0	0.1	0.1	-0.3	-0.3	-0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.3	-0.2	-0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	0.1	0.2	-0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.3	-0.2	0.1	-0.5

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IL12A

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