Hub : Genes

KPNA4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1380 0.0330 0.0e+00 0.211 0.185 0.204 0.190 0.207 3.5e-25 6.0e-22 2.4e-24 1.2e-22 1.0e-24
2 GTEx Testis 0.1370 0.0540 8.1e-05 0.039 NA 0.056 NA 0.045 7.7e-03 NA 1.7e-03 NA 4.4e-03
3 YFS Blood 0.0216 0.0092 7.0e-04 0.015 0.007 0.011 0.008 0.012 5.8e-06 1.3e-03 1.2e-04 1.1e-03 6.7e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.9 4.6 9.8 1.9 -0.8 -3.1
Bipolar Disorder or Schizophrenia 1.2 3.0 6.9 1.5 -0.1 -2.6
Depressed Affect (Nagel 2018) 0.0 0.1 0.1 -0.4 -0.0 -0.1
Depression (Nagel 2018) 0.0 0.1 0.1 -0.1 -0.4 -0.1
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.5 1.0 -1.2 -0.4
Neuroticism (Nagel 2018) 0.1 0.3 0.6 -0.2 -0.8 -0.4
Schizophrenia (2018) 0.2 0.4 0.7 0.4 0.5 -0.8
Schizophrenia vs Biploar Disorder 0.4 0.5 1.5 -0.2 0.1 1.2
Worry (Nagel 2018) 1.3 2.7 3.9 1.3 -2.0 -1.6
Alzheimer’s Disease (in mother) 0.6 0.7 1.1 1.1 -0.8 -0.6
Alzheimer’s Disease (in father) 0.2 0.2 0.6 0.2 -0.8 -0.3
Alzheimer’s Disease (including proxy) 0.1 0.2 0.3 -0.5 -0.1 0.6
Crohns Disease (2017) 0.0 0.0 0.1 -0.1 0.3 0.0
Irritable Bowel Disease (IBD) 0.2 0.5 1.2 -0.6 1.1 0.1
Ulcerative Colitis (UC) 0.4 0.7 1.8 -0.7 1.3 0.1
Major Depression (MDD) 0.1 0.1 0.1 -0.3 -0.4 -0.3
Reaction Time 1.1 2.1 3.2 -1.8 1.7 0.6
Verbal and Numeric Reasoning (VNR) 1.3 3.2 4.9 2.0 -2.2 -0.7
Breast Cancer 1.0 2.3 2.6 -1.4 1.6 1.5
Ovarian Cancer 0.2 0.3 0.5 -0.6 0.7 -0.4
Prostate Cancer 7.1 10.0 13.5 -3.7 2.5 3.2
Age at First Birth 2.4 3.5 4.9 -2.2 1.7 1.6
Bipolar Disorder (2011) 0.5 0.5 1.0 0.6 0.0 -1.0
Body Mass Index (BMI) (2010) 0.7 1.0 2.3 0.3 1.5 0.7
Coronary Artery Disease (CAD) 0.3 0.3 0.7 -0.2 0.5 -0.8
Crohns Disease (2012) 0.4 0.6 1.3 0.1 0.7 -1.2
Mean Putamen Volume 0.2 0.2 0.5 -0.1 0.7 -0.2
Fasting Glucose 5.8 6.9 8.5 2.7 -2.9 -2.3
HbA1C 3.0 3.3 4.5 1.8 -2.1 -1.5
HDL Cholesterol 1.1 1.8 4.1 1.0 -0.7 -2.0
LDL Cholesterol 5.3 8.4 11.6 3.4 -2.8 -2.4
Lupus 1.8 2.8 6.5 0.5 -1.3 -2.5
Neuroticism (2016) 2.9 4.2 5.0 1.8 -2.2 -2.1
Primary Biliary Cirrhosis 23.5 33.4 52.5 4.4 -7.2 -5.3
Rheumatoid Arthritis 4.1 5.6 8.9 1.9 -2.1 -3.0
Schizophrenia (2014) 0.6 1.4 2.7 1.2 0.2 -1.6
Triglycerides 0.9 1.5 3.5 1.0 -1.9 -0.1
Type 2 Diabetes (T2D) (2012) 0.6 0.6 1.5 -1.2 0.0 0.6
Ulcerative Colitis 0.5 0.8 2.0 0.4 0.4 -1.4
Blood Eosinophil Count 1.7 13.3 22.6 4.8 -3.1 -2.8
Blood Platelet Count 0.9 10.2 21.0 2.7 -4.6 -1.5
Blood Red Count 1.7 16.0 17.6 -4.0 3.8 4.2
Blood White Count 0.5 3.9 6.8 1.7 -1.4 -2.6
Heel T-Score 2.1 16.6 24.9 -4.1 5.0 2.8
BMI 0.4 2.2 3.0 -0.8 1.7 1.7
Height 0.3 4.9 8.4 -2.9 1.5 2.0
Waist Hip Ratio (WHR) 1.0 4.3 6.2 -2.1 1.5 2.5
Systolic Blood Pressure 6.7 33.3 42.4 6.5 -5.3 -5.4
Smoking Status 0.9 2.2 3.7 -1.2 1.1 1.9
Allergy or Eczema 0.3 0.7 1.3 0.4 0.7 -1.1
Cardiovascular Disease 5.1 16.8 19.4 4.4 -3.5 -4.4
Hypothyroidism (self reported) 2.7 6.2 12.5 2.5 -3.5 -0.3
Respiratory disease 0.9 2.0 3.6 1.9 -0.7 -1.4
Type 2 Diabetes (T2D) (2018) 2.6 4.9 6.4 2.5 -1.9 -2.2
Lung FEV1/FVC ratio 0.9 4.4 5.9 2.4 -2.3 -1.4
Lung FVC 1.1 5.5 7.9 -2.8 2.0 2.1
Neuroticism 0.3 0.6 1.4 0.3 -1.2 -0.7
Chronotype (morning person) 5.0 11.5 16.7 3.1 -2.8 -4.1
Hair Pigment 0.1 2.0 4.9 -1.1 2.2 0.1
Tanning 0.1 1.2 2.3 -1.0 0.6 1.5
Hand grip strength (left) 0.1 0.2 0.3 0.0 0.6 0.5
Number of treatments/medications taken 4.9 8.9 11.6 3.0 -3.4 -2.5
Average weekly spirits intake 0.9 1.2 2.3 -1.0 0.3 1.5
Sensitivity / hurt feelings 0.3 0.4 0.6 -0.8 0.5 0.7
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 -0.1 0.1 -0.6
Hearing difficulty/problems: Yes 0.2 0.3 0.7 -0.0 -0.8 0.3
Relative age of first facial hair 0.1 0.2 0.6 0.2 0.0 -0.7
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.8 -0.2 -0.9 0.4
Ever used hormone-replacement therapy (HRT) 8.0 10.2 13.0 3.6 -3.3 -2.6
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 0.6 -0.3 0.0
Systolic blood pressure, automated reading 5.8 16.8 22.9 4.8 -4.1 -3.2
Eye problems/disorders: Diabetes related eye disease 3.7 4.0 5.4 1.3 -2.3 -2.2
Angina 2.2 2.9 4.8 2.2 -1.6 -1.3
Medication for hormone replacement therapy 0.1 0.1 0.3 0.6 -0.2 -0.1
Vitamin and mineral supplements 0.9 1.3 1.7 0.9 -1.3 -1.1
Supplements: Zinc 0.4 0.4 1.2 -0.2 1.1 0.1
Medication: Co-codamol 3.5 4.0 8.0 1.3 -2.8 -1.5
Medication: Metformin 0.9 1.3 1.4 1.2 -1.0 -1.2
Diabetes (father) 0.9 1.2 1.8 1.1 -0.7 -1.3
Diabetes (mother) 3.5 4.5 6.7 2.6 -1.7 -2.0
Severe depression (siblings) 0.3 0.4 1.0 -0.1 0.2 1.0
Pack years adult smoking proportion 6.7 10.2 13.0 3.6 -2.8 -3.1
Impedance of leg (right) 2.2 10.8 13.3 2.9 -3.6 -3.3
Leg fat-free mass (left) 1.2 6.2 8.4 -2.2 2.3 2.9
Trunk fat percentage 0.0 0.1 0.1 0.4 0.3 -0.2
Hand grip strength (right) 0.1 0.2 0.5 0.7 -0.1 -0.1
Townsend deprivation index at recruitment 1.5 2.1 3.5 1.4 -0.8 -1.9
Current tobacco smoking 1.3 2.1 3.3 1.7 -0.4 -1.8
Average weekly fortified wine intake 0.4 0.4 0.8 0.4 -0.9 0.5
Maternal smoking around birth 1.6 2.3 3.5 1.4 -1.2 -1.9
Fed-up feelings 0.4 0.7 0.9 0.5 -0.9 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 0.7 0.5 0.4 -0.8
Relative age voice broke 0.7 1.0 1.5 1.0 -1.2 -0.8
Taking other prescription medications 1.7 2.7 4.0 1.4 -2.0 -1.5
Age when periods started (menarche) 0.1 0.3 0.8 0.2 -0.9 -0.4
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 0.9 0.8 -0.3 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 3.0 6.8 12.4 -2.3 3.5 1.6
Tinnitus: Yes, but not now, but have in the past 1.2 1.2 2.6 -1.0 1.6 0.3
Qualifications: CSEs or equivalent 0.1 0.1 0.2 0.5 0.1 0.2
Serious illness, injury or assault to yourself 0.1 0.1 0.3 0.2 -0.6 0.2
High blood pressure 4.3 12.0 13.7 3.6 -3.0 -3.7
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.1 0.5 1.0 -0.6
Multivitamins +/- minerals 0.5 0.6 0.9 -0.5 0.9 0.8
Stomach or abdominal pain in last month 1.3 1.6 2.1 -1.1 1.5 1.2
Supplements: Glucosamine 3.0 3.9 5.4 2.3 -2.0 -1.6
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.5 1.2 -0.9 -0.6
Medication: Atenolol 1.5 1.9 2.6 1.2 -1.3 -1.6
Medication: Levothyroxine sodium 0.9 1.5 2.6 1.4 -1.6 0.2
Sitting height 0.6 3.9 5.9 -2.1 1.2 2.4
Chronic bronchitis/emphysema (father) 4.7 5.5 7.8 2.2 -2.8 -1.9
High blood pressure (mother) 0.9 1.3 2.2 1.5 -0.8 -1.0
Body mass index (BMI) 0.4 1.5 2.9 -0.5 1.7 1.2
Impedance of leg (left) 1.8 8.7 10.3 2.7 -3.0 -3.2
Leg predicted mass (left) 1.2 6.4 8.8 -2.2 2.4 3.0
Trunk fat mass 0.1 0.4 0.6 -0.3 0.7 0.6
Waist circumference 0.3 1.3 1.8 -0.8 1.1 1.4
Number of incorrect matches in round 2.9 4.8 7.2 2.0 -2.7 -1.8
Past tobacco smoking 0.6 1.0 1.9 1.1 0.3 -1.4
Alcohol usually taken with meals 1.9 3.0 3.6 1.9 -1.4 -1.9
Nervous feelings 2.4 4.5 4.9 2.1 -2.2 -2.0
Frequency of tenseness / restlessness in last 2 weeks 3.2 5.0 5.8 2.1 -2.4 -2.2
Hearing difficulty/problems with background noise 0.1 0.1 0.2 0.5 -0.3 -0.3
Hair/balding pattern: Pattern 2 0.1 0.2 0.5 -0.2 0.7 0.1
Had menopause 1.6 1.9 3.1 1.0 -1.8 -1.3
Had other major operations 0.3 0.3 0.5 -0.7 0.3 0.6
Forced vital capacity (FVC) 0.2 0.9 1.3 -1.1 0.6 0.9
Heel bone mineral density (BMD) T-score, automated (right) 3.6 8.2 15.5 -2.5 3.9 1.6
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.9 -0.5 0.6 -1.0
Qualifications: None of the above 3.8 8.0 10.6 2.7 -3.2 -2.5
Financial difficulties in last 2 years 0.2 0.3 0.7 0.0 0.2 0.8
Mouth/teeth dental problems 0.8 1.2 2.8 0.1 -1.7 -0.9
Heart attack 1.0 1.2 1.5 1.2 -1.0 -1.1
Allergy 0.7 1.5 2.5 -1.6 -0.2 1.4
Pain all over the body in last month 0.3 0.4 0.8 -0.9 -0.1 0.6
Diabetes (self-reported) 5.2 8.0 10.7 3.0 -3.3 -2.1
Hayfever/allergic rhinitis (self-reported) 1.2 1.5 4.2 -0.6 2.1 0.3
Medication: Ramipril 1.3 1.6 2.2 1.5 -0.8 -1.4
Medication: Simvastatin 1.0 1.4 2.3 1.5 -1.1 -0.8
Fluid intelligence score 0.3 0.6 0.8 0.9 -0.8 0.4
Illnesses of siblings 2.1 3.0 4.7 -1.7 2.2 1.2
Neuroticism score 0.2 0.3 0.9 -0.0 -0.9 -0.4
Weight 0.4 2.1 2.5 -1.2 1.6 1.6
Impedance of arm (right) 1.1 5.3 7.5 1.3 -2.6 -2.7
Arm fat percentage (right) 0.0 0.0 0.1 0.3 0.1 0.1
Trunk fat-free mass 1.3 7.7 13.3 -2.5 1.8 3.7
Hip circumference 0.1 0.4 1.1 -0.1 1.0 0.2
Time employed in main current job 0.2 0.2 0.5 -0.7 -0.2 -0.3
Alcohol intake versus 10 years previously 2.3 3.5 5.6 1.4 -2.4 -1.7
Father’s age at death 0.5 0.6 1.1 1.1 -0.6 -0.6
Worrier / anxious feelings 0.2 0.5 1.3 -0.1 -0.3 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.2 1.1 -0.5 -0.3
Falls in the last year 0.2 0.2 0.4 0.6 -0.5 0.2
Hair/balding pattern: Pattern 3 0.3 0.4 0.9 -0.2 -0.9 0.6
Number of live births 0.5 0.8 1.5 -0.4 0.8 1.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 0.9 -0.9 0.6 0.9
Pulse rate 0.4 0.7 1.8 1.3 -0.4 -0.4
Happiness 0.0 0.1 0.1 -0.1 0.4 0.1
Noisy workplace 0.1 0.1 0.3 0.1 -0.5 0.1
Qualifications: A levels/AS levels or equivalent 0.9 1.9 3.5 -1.1 1.9 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.7 0.8 0.0 0.2
Mouth/teeth dental problems: Dentures 4.0 6.7 8.6 2.9 -2.1 -2.7
Asthma 2.3 4.6 6.7 2.6 -1.6 -2.1
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 3.1 -1.3 1.7 0.4
Medication: Cholesterol lowering 0.3 0.5 1.0 0.6 -1.0 -0.3
Depression (self-reported) 1.0 1.1 1.8 -0.3 1.2 -1.4
Medication: Lansoprazole 0.3 0.4 1.1 -0.2 0.1 1.1
Prospective memory result 0.6 0.7 1.1 -1.1 1.0 -0.3
Lung cancer (father) 0.1 0.1 0.1 -0.2 -0.4 -0.2
Illnesses of mother 6.8 8.4 11.0 -3.3 3.2 1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.3 -1.1 1.1 0.4
Pulse wave Arterial Stiffness index 0.3 0.4 0.8 0.2 -0.5 0.9
Impedance of arm (left) 1.2 5.4 8.4 1.6 -2.3 -2.9
Arm fat mass (right) 0.2 0.9 1.4 -0.5 1.0 1.2
Trunk predicted mass 1.4 7.7 13.2 -2.5 1.9 3.6
Standing height 0.1 1.2 2.4 -1.5 0.1 1.1
Length of working week for main job 1.1 1.2 2.0 -1.4 1.0 0.9
Exposure to tobacco smoke at home 0.3 0.3 0.6 -0.3 0.5 0.8
Breastfed as a baby 0.9 1.2 2.7 -0.3 -0.8 1.7
Tense / ‘highly strung’ 1.8 3.0 3.8 1.7 -1.9 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.0 0.1 -0.1 -0.1
Hair/balding pattern: Pattern 4 0.3 0.8 2.3 1.5 -0.5 0.0
Birth weight of first child 2.8 5.1 6.5 1.8 -2.5 -2.3
Peak expiratory flow (PEF) 0.0 0.1 0.2 -0.3 0.0 0.5
Pulse wave reflection index 2.2 2.7 4.5 -2.1 1.2 1.4
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.4 0.4 -1.2 -0.9
Loud music exposure frequency 0.4 0.4 0.8 0.1 -0.7 0.9
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.8 -0.4 1.7 0.2
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.6 -0.6 0.1 0.8
Blood clot in the leg (DVT) 0.7 0.9 1.8 0.9 -1.4 -0.3
Medication: Paracetamol 0.4 0.7 0.8 0.9 -0.9 -0.7
Headache pain in last month 0.9 1.5 4.1 -0.7 2.0 0.2
Medication for cholesterol, blood pressure or diabetes 2.8 4.6 7.1 -2.1 2.7 1.6
Glaucoma (self-reported) 3.5 4.1 5.8 2.4 -2.4 -0.9
Gout (self-reported) 1.0 1.3 2.3 0.7 -1.5 -1.1
Hypothyroidism/myxoedema (self-reported) 1.4 2.8 6.1 1.5 -2.5 0.1
Medication: Amlodipine 1.4 1.9 2.7 0.8 -1.5 -1.6
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 0.3 0.0 0.6
Birth weight 1.0 2.2 4.2 -1.5 0.2 2.1
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.6 1.3 -0.9 0.6
High blood pressure (siblings) 1.7 2.4 3.0 1.7 -1.2 -1.7
Forced vital capacity (FVC), Best measure 0.6 2.1 2.8 -1.7 1.6 0.9
Body fat percentage 0.0 0.1 0.3 0.5 0.2 -0.2
Leg fat percentage (right) 0.1 0.2 0.6 0.8 -0.3 -0.0
Arm fat-free mass (right) 1.3 6.4 10.4 -2.1 2.2 3.2
Exposure to tobacco smoke outside home 0.2 0.3 0.7 0.8 0.2 -0.4
Comparative body size at age 10 3.1 8.6 10.3 -3.2 2.6 3.0
Number of full brothers 0.6 0.7 1.6 1.3 -0.6 -0.3
Worry too long after embarrassment 0.2 0.3 0.8 -0.9 0.2 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.0 -0.1 0.0 -0.1
Wheeze or whistling in the chest in last year 0.8 1.5 2.4 1.5 0.3 -1.4
Number of children fathered 0.5 0.6 1.3 0.6 -1.1 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.6 3.1 1.8 -0.5 -1.1
Age at first live birth 3.2 5.6 7.8 -2.8 2.3 2.0
Pulse wave peak to peak time 0.2 0.2 0.3 -0.3 0.3 -0.6
Health satisfaction 0.3 0.4 0.8 0.3 0.6 -0.9
Shortness of breath walking on level ground 0.3 0.4 0.7 0.6 0.9 -0.4
Qualifications: College or University degree 2.9 9.1 14.6 -2.3 2.8 3.8
Eye problems/disorders: None of the above 1.8 2.1 4.0 -1.5 2.0 0.5
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.6 -0.4 1.6 0.2
Emphysema/chronic bronchitis 0.6 0.7 1.1 -1.1 0.9 0.6
Medication for pain relief, constipation, heartburn 0.3 0.5 0.7 -0.8 0.7 0.5
Neck or shoulder pain in last month 0.6 0.8 1.3 0.8 -0.7 -1.1
Medication: Blood pressure 3.4 6.0 7.8 2.3 -2.8 -2.2
Angina (self-reported) 2.1 2.8 4.8 2.2 -1.5 -1.2
Migraine (self-reported) 1.7 2.1 6.1 0.5 -0.2 -2.5
Medication: Ibuprofen 0.5 0.5 1.5 -0.3 1.2 0.2
Medication: Allopurinol 2.3 3.1 5.4 1.1 -2.3 -1.7
Medication: Omeprazole 0.3 0.3 0.6 -0.4 -0.8 -0.6
Medication: Seretide 50 evohaler 0.1 0.1 0.2 0.1 -0.1 -0.4
Mean time to correctly identify matches 0.3 0.6 1.3 -1.1 0.6 0.0
Heart disease (mother) 2.2 2.7 4.7 1.6 -2.2 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.6 4.2 5.2 2.2 -2.3 -1.7
Whole body fat mass 0.1 0.4 0.8 -0.2 0.9 0.6
Leg fat mass (right) 0.0 0.2 0.3 0.2 0.4 0.6
Arm predicted mass (right) 1.3 6.5 11.0 -2.1 2.1 3.3
Pulse rate, automated reading 0.1 0.2 0.6 0.1 0.2 0.8
Alcohol intake frequency. 3.3 7.7 9.7 2.5 -2.7 -3.1
Comparative height size at age 10 1.2 6.8 12.0 -2.6 1.3 3.5
Number of full sisters 2.0 2.4 4.5 2.1 -0.7 -1.5
Suffer from ‘nerves’ 4.5 7.1 12.2 2.1 -3.5 -2.2
Overall health rating 4.0 8.6 12.6 3.5 -2.4 -2.7
Chest pain or discomfort 1.7 2.5 5.4 2.3 -0.7 -1.3
Had major operations 2.0 2.4 4.4 -2.1 0.6 1.5
Age at last live birth 3.0 4.4 5.1 -2.2 2.0 2.0
Family relationship satisfaction 0.1 0.1 0.2 -0.3 0.5 -0.0
Leg pain on walking 0.4 0.5 0.8 0.9 0.4 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.3 0.5 -0.2 -1.5
Commuting to job workplace: Car/motor vehicle 1.2 1.3 1.8 1.2 -0.9 -1.4
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.7 1.1 0.0 -1.3
Medication: Aspirin 0.7 1.0 1.4 1.2 -1.0 -0.8
Supplements: Vitamin C 0.9 1.1 2.6 -0.8 -0.0 1.6
Knee pain experienced in last month 0.2 0.3 0.7 0.8 0.2 -0.1
Hypertension (Self-reported) 3.9 10.9 12.6 3.5 -2.8 -3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 2.9 -1.2 1.7 0.3
Illnesses of father: Heart disease 0.2 0.2 0.6 0.2 -0.4 0.7
Illnesses of siblings: Diabetes 6.2 7.6 10.2 3.2 -2.7 -2.4
Smoking status: Previous 1.2 1.8 4.0 -1.2 0.0 2.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.1 0.7 -0.2 -1.1
Whole body fat-free mass 1.4 8.1 12.5 -2.6 2.3 3.5
Leg fat-free mass (right) 1.5 8.1 9.8 -2.5 2.8 3.1
Arm fat percentage (left) 0.0 0.1 0.1 0.3 0.3 0.2
Average weekly red wine intake 0.2 0.2 0.6 -0.2 -0.2 0.8
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.9 -1.0 0.6 -0.1
Mood swings 0.0 0.0 0.1 0.0 -0.3 -0.2
Loneliness, isolation 0.5 0.6 1.8 0.3 -1.4 0.1
Long-standing illness, disability or infirmity 0.7 1.1 2.6 0.8 -1.6 0.2
Ever had bowel cancer screening 0.4 0.5 0.8 0.6 -0.9 -0.4
Diabetes diagnosed by doctor 4.2 6.9 8.6 2.6 -2.9 -2.3
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 0.7 0.8 0.8 -0.2
Friendships satisfaction 0.1 0.1 0.2 0.1 -0.3 -0.4
Qualifications: nursing, teaching 2.1 3.3 7.8 -1.3 2.8 0.7
Commuting to job workplace: Walk 1.5 1.6 1.9 -1.3 1.2 1.4
Eye problems/disorders: Cataract 0.3 0.3 0.7 -0.2 0.5 0.8
Mouth/teeth dental problems: Mouth ulcers 22.8 36.2 59.1 -4.7 7.7 5.2
Medication for cholesterol 4.6 7.0 10.0 -3.2 2.4 2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.6 -0.8 0.3 -0.5
Back pain experienced in last month 1.6 2.3 3.3 1.7 -0.8 -1.8
Mineral and other dietary supplements 0.1 0.1 0.3 -0.2 0.6 -0.0
Breast cancer (self-reported) 0.9 1.0 1.7 -1.3 0.9 0.8
Asthma (self-reported) 1.9 3.8 5.3 2.3 -1.4 -2.0
Osteoporosis (self-reported) 0.0 0.0 0.0 0.1 -0.2 -0.2
Osteoarthritis (self-reported) 0.3 0.4 0.9 1.0 -0.3 -0.4
Medication: Aspirin 1.0 1.3 2.2 1.5 -0.9 -0.9
Medication: Gliclazide 1.5 1.6 2.9 1.3 -0.6 -1.7
Illnesses of father: None of the above (group 1) 3.0 3.7 4.9 -2.0 1.5 2.2
Smoking status: Current 0.7 1.2 2.2 1.1 -0.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.2 2.8 -1.7 1.4 1.4
Whole body water mass 1.5 8.5 13.0 -2.6 2.4 3.6
Leg predicted mass (right) 1.6 8.3 10.0 -2.6 2.9 3.2
Arm fat mass (left) 0.3 1.0 1.5 -0.5 1.2 1.2
Number of self-reported non-cancer illnesses 6.4 11.1 13.9 3.3 -2.9 -3.7
Average weekly champagne plus white wine intake 0.4 0.6 1.5 -0.5 -0.1 1.2
Miserableness 0.6 1.1 2.4 -1.0 1.5 0.2
Guilty feelings 1.1 1.6 4.4 -2.1 0.5 0.5
Wears glasses or contact lenses 1.0 1.2 2.6 0.9 -1.6 -0.5
Ever taken oral contraceptive pill 0.2 0.2 0.5 -0.7 -0.3 0.3
Hearing aid user 1.6 1.8 2.1 1.2 -1.4 -1.4
Mother’s age at death 1.1 1.4 2.1 -1.0 1.1 1.5
Financial situation satisfaction 1.5 1.8 3.7 -1.0 1.9 0.9
Tinnitus: Yes, now most or all of the time 2.0 2.3 3.6 1.2 -1.4 -1.9
Commuting to job workplace: Public transport 0.0 0.0 0.1 -0.3 0.1 -0.1
Eye problems/disorders: Glaucoma 6.2 7.3 10.4 2.9 -3.2 -1.9
Medication: Blood pressure 0.6 1.1 1.8 1.0 -0.6 -1.4
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.6 1.3 -0.1 -0.9
Supplements: Fish oil (including cod liver oil) 1.3 1.7 2.3 1.2 -1.5 -1.1
High cholesterol (Self-reported) 4.0 7.1 7.4 2.6 -2.6 -2.7
Medication: Bendroflumethiazide 0.5 0.8 2.2 0.4 0.2 -1.5
Medication: Paracetamol 0.6 0.9 1.2 1.1 -0.9 -0.8
Medication: Lisinopril 1.4 1.9 3.3 1.1 -1.8 -0.9
Medication: Atorvastatin 3.0 3.7 5.3 1.0 -2.2 -2.3
Illnesses of father: High blood pressure 2.0 2.5 4.7 1.5 -0.8 -2.2
Alcohol drinker status: Never 0.4 0.5 0.9 0.7 0.4 -0.9
Ever smoked 0.3 0.6 1.0 -1.0 0.0 0.8
Basal metabolic rate 1.2 6.8 10.2 -2.3 2.2 3.2
Leg fat percentage (left) 0.0 0.1 0.3 0.5 0.3 0.0
Arm fat-free mass (left) 1.4 7.1 10.6 -2.3 2.3 3.3
Number of operations (self-reported) 3.2 4.8 9.6 -3.1 1.1 1.9
Average weekly beer plus cider intake 0.9 1.3 3.5 -0.4 1.9 0.4
Irritability 0.5 0.8 2.3 0.3 -1.5 0.4
Risk taking 1.1 1.6 3.7 -0.4 -1.1 1.9
Ever had prostate specific antigen (PSA) test 1.0 1.1 2.3 -1.5 0.2 1.0
Fractured/broken bones in last 5 years 0.7 0.9 1.4 -1.2 0.8 0.9
Age started oral contraceptive pill 0.1 0.1 0.2 0.0 0.4 0.4
Diastolic blood pressure, automated reading 0.6 2.0 2.5 1.5 -1.2 -1.6
Ever depressed for a whole week 0.0 0.0 0.0 0.0 0.2 -0.1
Unable to work because of sickness or disability 2.9 3.8 4.9 1.8 -1.8 -2.2
Commuting to job workplace: Cycle 2.0 2.4 4.4 -2.1 0.7 1.6
Myopia 0.3 0.4 0.8 -0.7 0.2 0.9
Vascular/heart problems diagnosed by doctor 3.9 10.6 12.5 -3.5 2.9 3.3
Cholesterol lowering medication 7.0 10.3 12.5 3.5 -3.0 -3.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 -0.5 -0.3 -0.6
Pain experienced in last month 0.3 0.5 1.3 -0.1 -1.2 0.2
Supplements: Calcium 0.3 0.3 0.6 0.8 -0.1 -0.6
Basal cell carcinoma (self-reported) 0.3 0.3 0.5 0.6 -0.3 -0.7
Heart attack/myocardial infarction (self-reported) 1.0 1.2 1.7 1.3 -1.2 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.6 1.0 -1.3 -0.3
Heart disease (siblings) 0.2 0.2 0.6 0.1 -0.8 -0.1
Alcohol drinker status: Previous 5.9 6.7 8.1 2.7 -2.1 -2.9
Pack years of smoking 6.8 10.1 11.7 3.4 -3.1 -3.0
Impedance of whole body 1.4 7.4 10.9 2.1 -2.6 -3.3
Leg fat mass (left) 0.1 0.4 0.7 -0.1 0.8 0.7
Arm predicted mass (left) 1.2 6.2 9.6 -2.1 2.1 3.1