TWAS hub - KPNA4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1380	0.0330	0.0e+00	0.211	0.185	0.204	0.190	0.207	3.5e-25	6.0e-22	2.4e-24	1.2e-22	1.0e-24
2	GTEx	Testis	0.1370	0.0540	8.1e-05	0.039	NA	0.056	NA	0.045	7.7e-03	NA	1.7e-03	NA	4.4e-03
3	YFS	Blood	0.0216	0.0092	7.0e-04	0.015	0.007	0.011	0.008	0.012	5.8e-06	1.3e-03	1.2e-04	1.1e-03	6.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Primary Biliary Cirrhosis	23.5	33.4	52.5	4.4	-7.2	-5.3
Mouth/teeth dental problems: Mouth ulcers	22.8	36.2	59.1	-4.7	7.7	5.2
Ever used hormone-replacement therapy (HRT)	8.0	10.2	13.0	3.6	-3.3	-2.6
Prostate Cancer	7.1	10.0	13.5	-3.7	2.5	3.2
Cholesterol lowering medication	7.0	10.3	12.5	3.5	-3.0	-3.1
Illnesses of mother	6.8	8.4	11.0	-3.3	3.2	1.9
Pack years of smoking	6.8	10.1	11.7	3.4	-3.1	-3.0
Systolic Blood Pressure	6.7	33.3	42.4	6.5	-5.3	-5.4
Pack years adult smoking proportion	6.7	10.2	13.0	3.6	-2.8	-3.1
Number of self-reported non-cancer illnesses	6.4	11.1	13.9	3.3	-2.9	-3.7
Illnesses of siblings: Diabetes	6.2	7.6	10.2	3.2	-2.7	-2.4
Eye problems/disorders: Glaucoma	6.2	7.3	10.4	2.9	-3.2	-1.9
Alcohol drinker status: Previous	5.9	6.7	8.1	2.7	-2.1	-2.9
Fasting Glucose	5.8	6.9	8.5	2.7	-2.9	-2.3
Systolic blood pressure, automated reading	5.8	16.8	22.9	4.8	-4.1	-3.2
LDL Cholesterol	5.3	8.4	11.6	3.4	-2.8	-2.4
Diabetes (self-reported)	5.2	8.0	10.7	3.0	-3.3	-2.1
Cardiovascular Disease	5.1	16.8	19.4	4.4	-3.5	-4.4
Chronotype (morning person)	5.0	11.5	16.7	3.1	-2.8	-4.1
Number of treatments/medications taken	4.9	8.9	11.6	3.0	-3.4	-2.5
Chronic bronchitis/emphysema (father)	4.7	5.5	7.8	2.2	-2.8	-1.9
Medication for cholesterol	4.6	7.0	10.0	-3.2	2.4	2.3
Suffer from ‘nerves’	4.5	7.1	12.2	2.1	-3.5	-2.2
High blood pressure	4.3	12.0	13.7	3.6	-3.0	-3.7
Diabetes diagnosed by doctor	4.2	6.9	8.6	2.6	-2.9	-2.3
Rheumatoid Arthritis	4.1	5.6	8.9	1.9	-2.1	-3.0
Mouth/teeth dental problems: Dentures	4.0	6.7	8.6	2.9	-2.1	-2.7
Overall health rating	4.0	8.6	12.6	3.5	-2.4	-2.7
High cholesterol (Self-reported)	4.0	7.1	7.4	2.6	-2.6	-2.7
Hypertension (Self-reported)	3.9	10.9	12.6	3.5	-2.8	-3.6
Vascular/heart problems diagnosed by doctor	3.9	10.6	12.5	-3.5	2.9	3.3
Qualifications: None of the above	3.8	8.0	10.6	2.7	-3.2	-2.5
Eye problems/disorders: Diabetes related eye disease	3.7	4.0	5.4	1.3	-2.3	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	3.6	8.2	15.5	-2.5	3.9	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.6	4.2	5.2	2.2	-2.3	-1.7
Medication: Co-codamol	3.5	4.0	8.0	1.3	-2.8	-1.5
Diabetes (mother)	3.5	4.5	6.7	2.6	-1.7	-2.0
Glaucoma (self-reported)	3.5	4.1	5.8	2.4	-2.4	-0.9
Medication: Blood pressure	3.4	6.0	7.8	2.3	-2.8	-2.2
Alcohol intake frequency.	3.3	7.7	9.7	2.5	-2.7	-3.1
Frequency of tenseness / restlessness in last 2 weeks	3.2	5.0	5.8	2.1	-2.4	-2.2
Age at first live birth	3.2	5.6	7.8	-2.8	2.3	2.0
Number of operations (self-reported)	3.2	4.8	9.6	-3.1	1.1	1.9
Comparative body size at age 10	3.1	8.6	10.3	-3.2	2.6	3.0
HbA1C	3.0	3.3	4.5	1.8	-2.1	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	3.0	6.8	12.4	-2.3	3.5	1.6
Supplements: Glucosamine	3.0	3.9	5.4	2.3	-2.0	-1.6
Age at last live birth	3.0	4.4	5.1	-2.2	2.0	2.0
Illnesses of father: None of the above (group 1)	3.0	3.7	4.9	-2.0	1.5	2.2
Medication: Atorvastatin	3.0	3.7	5.3	1.0	-2.2	-2.3
Bipolar Disorder (2018)	2.9	4.6	9.8	1.9	-0.8	-3.1
Neuroticism (2016)	2.9	4.2	5.0	1.8	-2.2	-2.1
Number of incorrect matches in round	2.9	4.8	7.2	2.0	-2.7	-1.8
Qualifications: College or University degree	2.9	9.1	14.6	-2.3	2.8	3.8
Unable to work because of sickness or disability	2.9	3.8	4.9	1.8	-1.8	-2.2
Birth weight of first child	2.8	5.1	6.5	1.8	-2.5	-2.3
Medication for cholesterol, blood pressure or diabetes	2.8	4.6	7.1	-2.1	2.7	1.6
Hypothyroidism (self reported)	2.7	6.2	12.5	2.5	-3.5	-0.3
Type 2 Diabetes (T2D) (2018)	2.6	4.9	6.4	2.5	-1.9	-2.2
Age at First Birth	2.4	3.5	4.9	-2.2	1.7	1.6
Nervous feelings	2.4	4.5	4.9	2.1	-2.2	-2.0
Alcohol intake versus 10 years previously	2.3	3.5	5.6	1.4	-2.4	-1.7
Asthma	2.3	4.6	6.7	2.6	-1.6	-2.1
Medication: Allopurinol	2.3	3.1	5.4	1.1	-2.3	-1.7
Angina	2.2	2.9	4.8	2.2	-1.6	-1.3
Impedance of leg (right)	2.2	10.8	13.3	2.9	-3.6	-3.3
Pulse wave reflection index	2.2	2.7	4.5	-2.1	1.2	1.4
Heart disease (mother)	2.2	2.7	4.7	1.6	-2.2	-0.9
Heel T-Score	2.1	16.6	24.9	-4.1	5.0	2.8
Illnesses of siblings	2.1	3.0	4.7	-1.7	2.2	1.2
Angina (self-reported)	2.1	2.8	4.8	2.2	-1.5	-1.2
Qualifications: nursing, teaching	2.1	3.3	7.8	-1.3	2.8	0.7
Number of full sisters	2.0	2.4	4.5	2.1	-0.7	-1.5
Had major operations	2.0	2.4	4.4	-2.1	0.6	1.5
Tinnitus: Yes, now most or all of the time	2.0	2.3	3.6	1.2	-1.4	-1.9
Illnesses of father: High blood pressure	2.0	2.5	4.7	1.5	-0.8	-2.2
Commuting to job workplace: Cycle	2.0	2.4	4.4	-2.1	0.7	1.6
Alcohol usually taken with meals	1.9	3.0	3.6	1.9	-1.4	-1.9
Asthma (self-reported)	1.9	3.8	5.3	2.3	-1.4	-2.0
Lupus	1.8	2.8	6.5	0.5	-1.3	-2.5
Impedance of leg (left)	1.8	8.7	10.3	2.7	-3.0	-3.2
Tense / ‘highly strung’	1.8	3.0	3.8	1.7	-1.9	-1.5
Eye problems/disorders: None of the above	1.8	2.1	4.0	-1.5	2.0	0.5
Blood Eosinophil Count	1.7	13.3	22.6	4.8	-3.1	-2.8
Blood Red Count	1.7	16.0	17.6	-4.0	3.8	4.2
Taking other prescription medications	1.7	2.7	4.0	1.4	-2.0	-1.5
High blood pressure (siblings)	1.7	2.4	3.0	1.7	-1.2	-1.7
Migraine (self-reported)	1.7	2.1	6.1	0.5	-0.2	-2.5
Chest pain or discomfort	1.7	2.5	5.4	2.3	-0.7	-1.3
Maternal smoking around birth	1.6	2.3	3.5	1.4	-1.2	-1.9
Had menopause	1.6	1.9	3.1	1.0	-1.8	-1.3
Back pain experienced in last month	1.6	2.3	3.3	1.7	-0.8	-1.8
Leg predicted mass (right)	1.6	8.3	10.0	-2.6	2.9	3.2
Hearing aid user	1.6	1.8	2.1	1.2	-1.4	-1.4
Townsend deprivation index at recruitment	1.5	2.1	3.5	1.4	-0.8	-1.9
Medication: Atenolol	1.5	1.9	2.6	1.2	-1.3	-1.6
Leg fat-free mass (right)	1.5	8.1	9.8	-2.5	2.8	3.1
Commuting to job workplace: Walk	1.5	1.6	1.9	-1.3	1.2	1.4
Medication: Gliclazide	1.5	1.6	2.9	1.3	-0.6	-1.7
Whole body water mass	1.5	8.5	13.0	-2.6	2.4	3.6
Financial situation satisfaction	1.5	1.8	3.7	-1.0	1.9	0.9
Trunk predicted mass	1.4	7.7	13.2	-2.5	1.9	3.6
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	6.1	1.5	-2.5	0.1
Medication: Amlodipine	1.4	1.9	2.7	0.8	-1.5	-1.6
Whole body fat-free mass	1.4	8.1	12.5	-2.6	2.3	3.5
Medication: Lisinopril	1.4	1.9	3.3	1.1	-1.8	-0.9
Arm fat-free mass (left)	1.4	7.1	10.6	-2.3	2.3	3.3
Impedance of whole body	1.4	7.4	10.9	2.1	-2.6	-3.3
Worry (Nagel 2018)	1.3	2.7	3.9	1.3	-2.0	-1.6
Verbal and Numeric Reasoning (VNR)	1.3	3.2	4.9	2.0	-2.2	-0.7
Current tobacco smoking	1.3	2.1	3.3	1.7	-0.4	-1.8
Stomach or abdominal pain in last month	1.3	1.6	2.1	-1.1	1.5	1.2
Medication: Ramipril	1.3	1.6	2.2	1.5	-0.8	-1.4
Trunk fat-free mass	1.3	7.7	13.3	-2.5	1.8	3.7
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	3.1	-1.3	1.7	0.4
Arm fat-free mass (right)	1.3	6.4	10.4	-2.1	2.2	3.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	3.1	1.8	-0.5	-1.1
Arm predicted mass (right)	1.3	6.5	11.0	-2.1	2.1	3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.9	-1.2	1.7	0.3
Supplements: Fish oil (including cod liver oil)	1.3	1.7	2.3	1.2	-1.5	-1.1
Bipolar Disorder or Schizophrenia	1.2	3.0	6.9	1.5	-0.1	-2.6
Leg fat-free mass (left)	1.2	6.2	8.4	-2.2	2.3	2.9
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	2.6	-1.0	1.6	0.3
Leg predicted mass (left)	1.2	6.4	8.8	-2.2	2.4	3.0
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	4.2	-0.6	2.1	0.3
Impedance of arm (left)	1.2	5.4	8.4	1.6	-2.3	-2.9
Comparative height size at age 10	1.2	6.8	12.0	-2.6	1.3	3.5
Commuting to job workplace: Car/motor vehicle	1.2	1.3	1.8	1.2	-0.9	-1.4
Smoking status: Previous	1.2	1.8	4.0	-1.2	0.0	2.0
Basal metabolic rate	1.2	6.8	10.2	-2.3	2.2	3.2
Arm predicted mass (left)	1.2	6.2	9.6	-2.1	2.1	3.1
Reaction Time	1.1	2.1	3.2	-1.8	1.7	0.6
HDL Cholesterol	1.1	1.8	4.1	1.0	-0.7	-2.0
Lung FVC	1.1	5.5	7.9	-2.8	2.0	2.1
Impedance of arm (right)	1.1	5.3	7.5	1.3	-2.6	-2.7
Length of working week for main job	1.1	1.2	2.0	-1.4	1.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	2.8	-1.7	1.4	1.4
Guilty feelings	1.1	1.6	4.4	-2.1	0.5	0.5
Mother’s age at death	1.1	1.4	2.1	-1.0	1.1	1.5
Risk taking	1.1	1.6	3.7	-0.4	-1.1	1.9
Breast Cancer	1.0	2.3	2.6	-1.4	1.6	1.5
Waist Hip Ratio (WHR)	1.0	4.3	6.2	-2.1	1.5	2.5
Heart attack	1.0	1.2	1.5	1.2	-1.0	-1.1
Medication: Simvastatin	1.0	1.4	2.3	1.5	-1.1	-0.8
Depression (self-reported)	1.0	1.1	1.8	-0.3	1.2	-1.4
Gout (self-reported)	1.0	1.3	2.3	0.7	-1.5	-1.1
Birth weight	1.0	2.2	4.2	-1.5	0.2	2.1
Medication: Aspirin	1.0	1.3	2.2	1.5	-0.9	-0.9
Wears glasses or contact lenses	1.0	1.2	2.6	0.9	-1.6	-0.5
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.3	-1.5	0.2	1.0
Heart attack/myocardial infarction (self-reported)	1.0	1.2	1.7	1.3	-1.2	-0.8
Triglycerides	0.9	1.5	3.5	1.0	-1.9	-0.1
Blood Platelet Count	0.9	10.2	21.0	2.7	-4.6	-1.5
Smoking Status	0.9	2.2	3.7	-1.2	1.1	1.9
Respiratory disease	0.9	2.0	3.6	1.9	-0.7	-1.4
Lung FEV1/FVC ratio	0.9	4.4	5.9	2.4	-2.3	-1.4
Average weekly spirits intake	0.9	1.2	2.3	-1.0	0.3	1.5
Vitamin and mineral supplements	0.9	1.3	1.7	0.9	-1.3	-1.1
Medication: Metformin	0.9	1.3	1.4	1.2	-1.0	-1.2
Diabetes (father)	0.9	1.2	1.8	1.1	-0.7	-1.3
Medication: Levothyroxine sodium	0.9	1.5	2.6	1.4	-1.6	0.2
High blood pressure (mother)	0.9	1.3	2.2	1.5	-0.8	-1.0
Qualifications: A levels/AS levels or equivalent	0.9	1.9	3.5	-1.1	1.9	1.1
Breastfed as a baby	0.9	1.2	2.7	-0.3	-0.8	1.7
Headache pain in last month	0.9	1.5	4.1	-0.7	2.0	0.2
Supplements: Vitamin C	0.9	1.1	2.6	-0.8	-0.0	1.6
Breast cancer (self-reported)	0.9	1.0	1.7	-1.3	0.9	0.8
Average weekly beer plus cider intake	0.9	1.3	3.5	-0.4	1.9	0.4
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.5	1.2	-0.9	-0.6
Mouth/teeth dental problems	0.8	1.2	2.8	0.1	-1.7	-0.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.6	1.3	-0.9	0.6
Wheeze or whistling in the chest in last year	0.8	1.5	2.4	1.5	0.3	-1.4
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.6	-0.4	1.6	0.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.7	1.1	0.0	-1.3
Body Mass Index (BMI) (2010)	0.7	1.0	2.3	0.3	1.5	0.7
Relative age voice broke	0.7	1.0	1.5	1.0	-1.2	-0.8
Allergy	0.7	1.5	2.5	-1.6	-0.2	1.4
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.4	0.4	-1.2	-0.9
Blood clot in the leg (DVT)	0.7	0.9	1.8	0.9	-1.4	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.3	0.5	-0.2	-1.5
Medication: Aspirin	0.7	1.0	1.4	1.2	-1.0	-0.8
Long-standing illness, disability or infirmity	0.7	1.1	2.6	0.8	-1.6	0.2
Smoking status: Current	0.7	1.2	2.2	1.1	-0.1	-1.5
Fractured/broken bones in last 5 years	0.7	0.9	1.4	-1.2	0.8	0.9
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.6	1.0	-1.3	-0.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.1	1.1	-0.8	-0.6
Schizophrenia (2014)	0.6	1.4	2.7	1.2	0.2	-1.6
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.5	-1.2	0.0	0.6
Sitting height	0.6	3.9	5.9	-2.1	1.2	2.4
Past tobacco smoking	0.6	1.0	1.9	1.1	0.3	-1.4
Prospective memory result	0.6	0.7	1.1	-1.1	1.0	-0.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.8	-0.4	1.7	0.2
Forced vital capacity (FVC), Best measure	0.6	2.1	2.8	-1.7	1.6	0.9
Number of full brothers	0.6	0.7	1.6	1.3	-0.6	-0.3
Emphysema/chronic bronchitis	0.6	0.7	1.1	-1.1	0.9	0.6
Neck or shoulder pain in last month	0.6	0.8	1.3	0.8	-0.7	-1.1
Miserableness	0.6	1.1	2.4	-1.0	1.5	0.2
Medication: Blood pressure	0.6	1.1	1.8	1.0	-0.6	-1.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.6	1.3	-0.1	-0.9
Medication: Paracetamol	0.6	0.9	1.2	1.1	-0.9	-0.8
Diastolic blood pressure, automated reading	0.6	2.0	2.5	1.5	-1.2	-1.6
Bipolar Disorder (2011)	0.5	0.5	1.0	0.6	0.0	-1.0
Ulcerative Colitis	0.5	0.8	2.0	0.4	0.4	-1.4
Blood White Count	0.5	3.9	6.8	1.7	-1.4	-2.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	0.9	0.8	-0.3	-0.9
Multivitamins +/- minerals	0.5	0.6	0.9	-0.5	0.9	0.8
Father’s age at death	0.5	0.6	1.1	1.1	-0.6	-0.6
Number of live births	0.5	0.8	1.5	-0.4	0.8	1.2
Number of children fathered	0.5	0.6	1.3	0.6	-1.1	0.3
Medication: Ibuprofen	0.5	0.5	1.5	-0.3	1.2	0.2
Loneliness, isolation	0.5	0.6	1.8	0.3	-1.4	0.1
Medication: Bendroflumethiazide	0.5	0.8	2.2	0.4	0.2	-1.5
Irritability	0.5	0.8	2.3	0.3	-1.5	0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	-0.2	0.1	1.2
Ulcerative Colitis (UC)	0.4	0.7	1.8	-0.7	1.3	0.1
Crohns Disease (2012)	0.4	0.6	1.3	0.1	0.7	-1.2
BMI	0.4	2.2	3.0	-0.8	1.7	1.7
Supplements: Zinc	0.4	0.4	1.2	-0.2	1.1	0.1
Average weekly fortified wine intake	0.4	0.4	0.8	0.4	-0.9	0.5
Fed-up feelings	0.4	0.7	0.9	0.5	-0.9	-1.0
Body mass index (BMI)	0.4	1.5	2.9	-0.5	1.7	1.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	-0.5	0.6	-1.0
Weight	0.4	2.1	2.5	-1.2	1.6	1.6
Pulse rate	0.4	0.7	1.8	1.3	-0.4	-0.4
Loud music exposure frequency	0.4	0.4	0.8	0.1	-0.7	0.9
Medication: Paracetamol	0.4	0.7	0.8	0.9	-0.9	-0.7
Leg pain on walking	0.4	0.5	0.8	0.9	0.4	-0.8
Ever had bowel cancer screening	0.4	0.5	0.8	0.6	-0.9	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.7	0.8	0.8	-0.2
Average weekly champagne plus white wine intake	0.4	0.6	1.5	-0.5	-0.1	1.2
Alcohol drinker status: Never	0.4	0.5	0.9	0.7	0.4	-0.9
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.5	1.0	-1.2	-0.4
Coronary Artery Disease (CAD)	0.3	0.3	0.7	-0.2	0.5	-0.8
Height	0.3	4.9	8.4	-2.9	1.5	2.0
Allergy or Eczema	0.3	0.7	1.3	0.4	0.7	-1.1
Neuroticism	0.3	0.6	1.4	0.3	-1.2	-0.7
Sensitivity / hurt feelings	0.3	0.4	0.6	-0.8	0.5	0.7
Severe depression (siblings)	0.3	0.4	1.0	-0.1	0.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.7	0.5	0.4	-0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	0.5	1.0	-0.6
Waist circumference	0.3	1.3	1.8	-0.8	1.1	1.4
Had other major operations	0.3	0.3	0.5	-0.7	0.3	0.6
Pain all over the body in last month	0.3	0.4	0.8	-0.9	-0.1	0.6
Fluid intelligence score	0.3	0.6	0.8	0.9	-0.8	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	1.1	-0.5	-0.3
Hair/balding pattern: Pattern 3	0.3	0.4	0.9	-0.2	-0.9	0.6
Medication: Cholesterol lowering	0.3	0.5	1.0	0.6	-1.0	-0.3
Medication: Lansoprazole	0.3	0.4	1.1	-0.2	0.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.3	-1.1	1.1	0.4
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	0.2	-0.5	0.9
Exposure to tobacco smoke at home	0.3	0.3	0.6	-0.3	0.5	0.8
Hair/balding pattern: Pattern 4	0.3	0.8	2.3	1.5	-0.5	0.0
Health satisfaction	0.3	0.4	0.8	0.3	0.6	-0.9
Shortness of breath walking on level ground	0.3	0.4	0.7	0.6	0.9	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.5	0.7	-0.8	0.7	0.5
Medication: Omeprazole	0.3	0.3	0.6	-0.4	-0.8	-0.6
Mean time to correctly identify matches	0.3	0.6	1.3	-1.1	0.6	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.1	0.7	-0.2	-1.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	-1.0	0.6	-0.1
Eye problems/disorders: Cataract	0.3	0.3	0.7	-0.2	0.5	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	-0.8	0.3	-0.5
Osteoarthritis (self-reported)	0.3	0.4	0.9	1.0	-0.3	-0.4
Arm fat mass (left)	0.3	1.0	1.5	-0.5	1.2	1.2
Ever smoked	0.3	0.6	1.0	-1.0	0.0	0.8
Myopia	0.3	0.4	0.8	-0.7	0.2	0.9
Pain experienced in last month	0.3	0.5	1.3	-0.1	-1.2	0.2
Supplements: Calcium	0.3	0.3	0.6	0.8	-0.1	-0.6
Basal cell carcinoma (self-reported)	0.3	0.3	0.5	0.6	-0.3	-0.7
Schizophrenia (2018)	0.2	0.4	0.7	0.4	0.5	-0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.2	-0.8	-0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	-0.6	1.1	0.1
Ovarian Cancer	0.2	0.3	0.5	-0.6	0.7	-0.4
Mean Putamen Volume	0.2	0.2	0.5	-0.1	0.7	-0.2
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.0	-0.8	0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	-0.2	-0.9	0.4
Forced vital capacity (FVC)	0.2	0.9	1.3	-1.1	0.6	0.9
Financial difficulties in last 2 years	0.2	0.3	0.7	0.0	0.2	0.8
Neuroticism score	0.2	0.3	0.9	-0.0	-0.9	-0.4
Time employed in main current job	0.2	0.2	0.5	-0.7	-0.2	-0.3
Worrier / anxious feelings	0.2	0.5	1.3	-0.1	-0.3	-1.1
Falls in the last year	0.2	0.2	0.4	0.6	-0.5	0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	0.9	-0.9	0.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	0.8	0.0	0.2
Arm fat mass (right)	0.2	0.9	1.4	-0.5	1.0	1.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	-0.6	0.1	0.8
Exposure to tobacco smoke outside home	0.2	0.3	0.7	0.8	0.2	-0.4
Worry too long after embarrassment	0.2	0.3	0.8	-0.9	0.2	-0.3
Pulse wave peak to peak time	0.2	0.2	0.3	-0.3	0.3	-0.6
Knee pain experienced in last month	0.2	0.3	0.7	0.8	0.2	-0.1
Illnesses of father: Heart disease	0.2	0.2	0.6	0.2	-0.4	0.7
Average weekly red wine intake	0.2	0.2	0.6	-0.2	-0.2	0.8
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.7	-0.3	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.5	-0.3	-0.6
Heart disease (siblings)	0.2	0.2	0.6	0.1	-0.8	-0.1
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.2	-0.8	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	-0.5	-0.1	0.6
Major Depression (MDD)	0.1	0.1	0.1	-0.3	-0.4	-0.3
Hair Pigment	0.1	2.0	4.9	-1.1	2.2	0.1
Tanning	0.1	1.2	2.3	-1.0	0.6	1.5
Hand grip strength (left)	0.1	0.2	0.3	0.0	0.6	0.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.1	0.1	-0.6
Relative age of first facial hair	0.1	0.2	0.6	0.2	0.0	-0.7
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.6	-0.3	0.0
Medication for hormone replacement therapy	0.1	0.1	0.3	0.6	-0.2	-0.1
Hand grip strength (right)	0.1	0.2	0.5	0.7	-0.1	-0.1
Age when periods started (menarche)	0.1	0.3	0.8	0.2	-0.9	-0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.5	0.1	0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.2	-0.6	0.2
Trunk fat mass	0.1	0.4	0.6	-0.3	0.7	0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.5	-0.3	-0.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	-0.2	0.7	0.1
Hip circumference	0.1	0.4	1.1	-0.1	1.0	0.2
Noisy workplace	0.1	0.1	0.3	0.1	-0.5	0.1
Lung cancer (father)	0.1	0.1	0.1	-0.2	-0.4	-0.2
Standing height	0.1	1.2	2.4	-1.5	0.1	1.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.3	0.0	0.6
Leg fat percentage (right)	0.1	0.2	0.6	0.8	-0.3	-0.0
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.1	-0.1	-0.4
Whole body fat mass	0.1	0.4	0.8	-0.2	0.9	0.6
Pulse rate, automated reading	0.1	0.2	0.6	0.1	0.2	0.8
Family relationship satisfaction	0.1	0.1	0.2	-0.3	0.5	-0.0
Friendships satisfaction	0.1	0.1	0.2	0.1	-0.3	-0.4
Mineral and other dietary supplements	0.1	0.1	0.3	-0.2	0.6	-0.0
Age started oral contraceptive pill	0.1	0.1	0.2	0.0	0.4	0.4
Leg fat mass (left)	0.1	0.4	0.7	-0.1	0.8	0.7
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	-0.4	-0.0	-0.1
Depression (Nagel 2018)	0.0	0.1	0.1	-0.1	-0.4	-0.1
Crohns Disease (2017)	0.0	0.0	0.1	-0.1	0.3	0.0
Trunk fat percentage	0.0	0.1	0.1	0.4	0.3	-0.2
Arm fat percentage (right)	0.0	0.0	0.1	0.3	0.1	0.1
Happiness	0.0	0.1	0.1	-0.1	0.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.1	-0.1	-0.1
Peak expiratory flow (PEF)	0.0	0.1	0.2	-0.3	0.0	0.5
Body fat percentage	0.0	0.1	0.3	0.5	0.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.1	0.0	-0.1
Leg fat mass (right)	0.0	0.2	0.3	0.2	0.4	0.6
Arm fat percentage (left)	0.0	0.1	0.1	0.3	0.3	0.2
Mood swings	0.0	0.0	0.1	0.0	-0.3	-0.2
Osteoporosis (self-reported)	0.0	0.0	0.0	0.1	-0.2	-0.2
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.3	0.1	-0.1
Leg fat percentage (left)	0.0	0.1	0.3	0.5	0.3	0.0
Ever depressed for a whole week	0.0	0.0	0.0	0.0	0.2	-0.1

Hub : Genes

KPNA4

Models

Trait associations