Best TWAS P=8.2e-10 · Best GWAS P=8.2e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CISD2 | 0.02 | 0.00 | blup | 322 | 0.00 | 2.7e-01 | -5.1 | 6.0 | 1.7e-09 | 0.80 | 0.11 | 0.54 | FALSE |
| 2 | GTEx | Lung | CISD2 | 0.06 | 0.05 | enet | 10 | 0.04 | 5.4e-04 | 4.2 | -5.2 | 1.9e-07 | -0.69 | 0.34 | 0.62 | FALSE |
| 3 | GTEx | Muscle Skeletal | CISD2 | 0.03 | 0.02 | enet | 15 | 0.03 | 7.9e-04 | -4.3 | -5.2 | 1.7e-07 | -0.87 | 0.05 | 0.93 | FALSE |
| 4 | GTEx | Pancreas | MANBA | 0.14 | 0.14 | enet | 5 | 0.06 | 1.8e-03 | 6.1 | -6.1 | 9.7e-10 | -1.00 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | MANBA | 0.11 | 0.03 | lasso | 4 | 0.04 | 1.3e-04 | -5.4 | -5.2 | 2.5e-07 | -0.85 | 0.02 | 0.98 | FALSE |
| 6 | METSIM | Adipose | SLC9B1 | 0.02 | 0.03 | lasso | 8 | 0.02 | 1.2e-04 | 6.1 | 6.1 | 8.2e-10 | 1.00 | 0.02 | 0.97 | TRUE |
| 7 | YFS | Blood | MANBA | 0.09 | 0.10 | lasso | 3 | 0.10 | 5.2e-30 | 6.1 | 6.1 | 9.1e-10 | 1.00 | 0.02 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MANBA | 0.03 | 0.03 | blup | 71 | 0.04 | 2.0e-05 | 4.1 | 5.5 | 3.3e-08 | 0.74 | 0.37 | 0.52 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | NFKB1 | 0.10 | 0.06 | blup | 90 | 0.07 | 2.2e-03 | 4.6 | -6.0 | 1.6e-09 | -0.71 | 0.11 | 0.65 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | NFKB1 | 0.06 | 0.09 | enet | 7 | 0.09 | 9.1e-09 | 4.8 | 5.5 | 3.9e-08 | 0.58 | 0.31 | 0.69 | FALSE |