Hub : Genes

NFKB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0364 0.0136 2.8e-06 0.029 0.018 0.022 0.025 0.026 7.2e-10 1.0e-06 7.9e-08 1.2e-08 5.4e-09
2 TCGA Testicular Germ Cell Tumors 0.1000 0.0510 6.1e-04 0.057 0.067 0.003 NA 0.043 4.5e-03 2.2e-03 2.5e-01 NA 1.2e-02
3 TCGA Thyroid Carcinoma 0.0640 0.0270 4.4e-08 0.085 0.082 0.086 NA 0.082 1.1e-08 2.0e-08 9.1e-09 NA 2.1e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.5 0.7 -0.6 0.8 -0.8
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 0.3 -0.4 0.3
Depressed Affect (Nagel 2018) 0.1 0.2 0.3 -0.4 0.5 -0.5
Depression (Nagel 2018) 0.0 0.0 0.1 0.0 0.3 0.1
Intelligence (Savage-Jansen 2018) 0.7 2.1 3.6 1.9 -1.4 0.8
Neuroticism (Nagel 2018) 0.0 0.0 0.0 0.2 -0.0 0.1
Schizophrenia (2018) 0.5 1.0 1.3 0.8 -1.1 1.0
Schizophrenia vs Biploar Disorder 0.7 0.9 1.4 0.7 -1.2 1.0
Worry (Nagel 2018) 1.0 2.2 2.7 1.5 -1.6 1.3
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 -0.1 0.1 -0.2
Alzheimer’s Disease (in father) 0.1 0.2 0.3 0.5 -0.2 0.4
Alzheimer’s Disease (including proxy) 0.0 0.0 0.1 0.3 -0.1 0.1
Crohns Disease (2017) 7.6 16.7 19.7 -4.4 4.1 -3.7
Irritable Bowel Disease (IBD) 0.0 0.1 0.2 -0.4 0.0 0.1
Ulcerative Colitis (UC) 6.3 11.9 13.5 3.3 -3.7 3.4
Major Depression (MDD) 0.2 0.3 0.6 0.8 -0.5 0.2
Reaction Time 0.1 0.2 0.5 0.2 -0.7 0.2
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.2 -0.2 0.3 -0.4
Breast Cancer 0.0 0.1 0.2 -0.1 0.0 -0.5
Ovarian Cancer 0.1 0.2 0.2 -0.5 0.4 -0.4
Prostate Cancer 0.2 0.3 0.5 0.3 -0.7 0.5
Age at First Birth 2.1 3.0 4.7 -2.2 1.6 -1.4
Bipolar Disorder (2011) 0.5 0.5 0.6 -0.6 0.8 -0.8
Body Mass Index (BMI) (2010) 0.1 0.1 0.1 0.1 0.4 0.4
Coronary Artery Disease (CAD) 0.8 1.0 1.2 1.1 -1.1 0.7
Crohns Disease (2012) 2.5 4.0 4.7 -2.2 2.2 -1.6
Mean Putamen Volume 0.2 0.3 0.8 -0.9 0.1 0.0
Fasting Glucose 2.7 3.2 5.0 -1.4 2.2 -1.6
HbA1C 1.8 2.0 3.0 -1.6 1.7 -0.7
HDL Cholesterol 3.0 5.0 5.9 2.4 -2.2 2.1
LDL Cholesterol 0.5 0.8 1.2 1.1 -0.6 0.9
Lupus 0.1 0.1 0.2 0.5 -0.3 0.2
Neuroticism (2016) 0.3 0.5 1.0 1.0 -0.5 0.4
Primary Biliary Cirrhosis 20.9 29.8 36.4 4.8 -6.0 5.5
Rheumatoid Arthritis 0.0 0.0 0.0 0.0 0.0 0.0
Schizophrenia (2014) 0.2 0.4 0.7 0.4 -0.9 0.6
Triglycerides 1.3 2.1 3.2 1.1 -1.4 1.8
Type 2 Diabetes (T2D) (2012) 5.9 6.9 9.1 -2.4 3.0 -2.4
Ulcerative Colitis 9.0 13.1 14.4 3.5 -3.8 3.6
Blood Eosinophil Count 1.9 14.7 16.5 3.4 -4.1 4.0
Blood Platelet Count 0.8 9.3 11.0 -3.2 2.6 -3.3
Blood Red Count 4.7 45.1 47.5 -6.6 6.9 -6.7
Blood White Count 0.2 1.3 2.5 0.7 -1.6 1.0
Heel T-Score 0.0 0.1 0.2 0.1 -0.4 -0.3
BMI 0.1 0.6 1.6 -0.2 1.3 -0.1
Height 1.3 25.0 28.0 5.3 -4.8 4.8
Waist Hip Ratio (WHR) 0.3 1.3 1.8 0.8 -1.3 1.1
Systolic Blood Pressure 0.3 1.6 2.7 1.6 -0.9 1.2
Smoking Status 0.0 0.0 0.0 0.1 0.0 0.0
Allergy or Eczema 19.9 52.4 61.5 -6.8 7.8 -7.1
Cardiovascular Disease 0.3 1.0 2.8 -0.0 1.7 -0.3
Hypothyroidism (self reported) 0.3 0.6 0.8 -0.8 0.9 -0.6
Respiratory disease 3.0 6.6 9.3 -2.1 3.0 -2.4
Type 2 Diabetes (T2D) (2018) 2.6 4.8 6.0 -2.4 2.0 -2.1
Lung FEV1/FVC ratio 2.2 11.4 12.0 -3.5 3.2 -3.5
Lung FVC 0.5 2.5 4.5 -2.1 1.1 -1.4
Neuroticism 0.0 0.0 0.0 0.2 0.0 -0.1
Chronotype (morning person) 0.2 0.6 1.4 -0.0 1.2 -0.5
Hair Pigment 0.1 1.9 3.0 1.4 -0.9 1.7
Tanning 0.2 1.9 2.6 -1.6 1.0 -1.4
Hand grip strength (left) 2.2 5.8 7.0 2.6 -1.9 2.6
Number of treatments/medications taken 3.1 5.5 9.3 -1.7 3.1 -2.1
Average weekly spirits intake 1.9 2.4 3.2 -1.8 1.4 -1.4
Sensitivity / hurt feelings 0.3 0.6 1.0 -0.1 1.0 -0.8
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.6 -0.3 0.8 -0.5
Hearing difficulty/problems: Yes 5.7 8.7 9.5 -3.1 3.0 -2.7
Relative age of first facial hair 0.7 1.4 2.3 0.8 -1.5 1.1
Other serious medical condition/disability diagnosed by doctor 3.7 4.8 5.4 2.0 -2.3 2.3
Ever used hormone-replacement therapy (HRT) 3.1 3.9 5.9 -1.3 2.4 -2.0
Ever had hysterectomy (womb removed) 0.2 0.3 0.6 -0.2 0.8 -0.4
Systolic blood pressure, automated reading 0.2 0.4 0.6 -0.5 0.8 -0.7
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 2.5 -1.3 1.6 -1.3
Angina 0.1 0.1 0.1 0.3 0.4 -0.1
Medication for hormone replacement therapy 2.3 2.6 2.8 -1.5 1.7 -1.6
Vitamin and mineral supplements 1.7 2.3 2.4 1.5 -1.5 1.5
Supplements: Zinc 0.0 0.0 0.0 -0.1 0.2 -0.2
Medication: Co-codamol 0.0 0.0 0.0 0.2 -0.2 0.2
Medication: Metformin 4.6 6.5 7.3 -2.6 2.7 -2.4
Diabetes (father) 0.2 0.2 0.5 0.3 -0.2 0.7
Diabetes (mother) 1.6 2.1 2.5 -1.5 1.6 -1.3
Severe depression (siblings) 0.8 0.9 1.1 1.1 -0.8 1.0
Pack years adult smoking proportion 0.2 0.3 0.4 0.7 0.6 0.4
Impedance of leg (right) 0.1 0.5 1.1 -1.0 -0.0 -0.7
Leg fat-free mass (left) 0.3 1.8 2.8 1.7 -0.8 1.4
Trunk fat percentage 0.3 1.0 1.1 -1.0 1.0 -1.0
Hand grip strength (right) 2.0 5.6 7.1 2.7 -2.0 2.4
Townsend deprivation index at recruitment 0.2 0.3 0.4 -0.6 0.5 -0.5
Current tobacco smoking 0.2 0.3 0.6 -0.8 0.4 -0.5
Average weekly fortified wine intake 0.6 0.7 0.9 -0.9 0.7 -0.9
Maternal smoking around birth 1.0 1.5 3.0 0.1 1.7 -1.2
Fed-up feelings 1.5 2.8 3.4 -1.7 1.9 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.2 -0.3 1.1 -0.7
Relative age voice broke 1.2 1.9 2.7 0.9 -1.6 1.5
Taking other prescription medications 2.4 3.8 6.1 -1.6 2.5 -1.6
Age when periods started (menarche) 6.8 16.3 19.9 -4.5 3.5 -4.1
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.1 -0.7 1.4 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.6 0.4 -1.6 1.0
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 0.8 0.9 -0.9 0.6
Qualifications: CSEs or equivalent 0.0 0.1 0.1 -0.1 0.3 -0.3
Serious illness, injury or assault to yourself 0.3 0.4 0.8 0.4 -0.4 0.9
High blood pressure 0.8 2.1 5.0 -0.6 2.2 -1.0
Hayfever, allergic rhinitis or eczema 16.8 36.4 42.6 -5.7 6.5 -5.8
Multivitamins +/- minerals 2.8 3.6 3.6 -1.9 1.9 -1.9
Stomach or abdominal pain in last month 0.0 0.0 0.0 0.0 -0.0 0.1
Supplements: Glucosamine 1.0 1.3 1.6 -1.3 1.1 -1.1
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.1 0.3 -0.3 0.0
Medication: Atenolol 0.6 0.8 1.1 -0.5 1.0 -1.0
Medication: Levothyroxine sodium 1.1 1.8 2.4 -1.5 1.3 -1.2
Sitting height 2.1 14.7 17.1 4.1 -3.5 3.8
Chronic bronchitis/emphysema (father) 1.8 2.1 2.7 -1.6 1.5 -1.2
High blood pressure (mother) 0.1 0.1 0.3 -0.1 0.6 -0.3
Body mass index (BMI) 0.6 2.6 4.0 -1.3 2.0 -1.4
Impedance of leg (left) 0.1 0.4 0.9 -0.9 -0.1 -0.5
Leg predicted mass (left) 0.3 1.7 2.7 1.6 -0.7 1.4
Trunk fat mass 0.0 0.2 0.3 -0.2 0.6 -0.4
Waist circumference 0.0 0.1 0.1 -0.1 0.4 0.1
Number of incorrect matches in round 0.9 1.5 2.2 -1.5 1.2 -0.9
Past tobacco smoking 0.1 0.3 0.4 -0.3 -0.5 0.6
Alcohol usually taken with meals 0.0 0.1 0.1 -0.2 -0.3 0.1
Nervous feelings 2.8 5.2 6.6 2.2 -2.6 2.1
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.1 0.1 0.2 -0.3 0.1
Hearing difficulty/problems with background noise 0.9 1.5 1.6 -1.1 1.3 -1.2
Hair/balding pattern: Pattern 2 1.4 1.8 2.0 -1.3 1.3 -1.4
Had menopause 1.8 2.2 2.6 -1.3 1.6 -1.5
Had other major operations 1.6 1.9 2.5 -1.4 1.6 -1.2
Forced vital capacity (FVC) 0.2 0.6 0.9 0.6 -0.8 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.7 0.4 -0.8 0.4
Ever unenthusiastic/disinterested for a whole week 2.0 2.4 2.8 -1.7 1.4 -1.6
Qualifications: None of the above 2.2 4.8 5.4 -2.0 2.2 -2.3
Financial difficulties in last 2 years 0.7 1.0 1.9 1.4 -0.8 0.7
Mouth/teeth dental problems 4.8 7.3 9.4 2.0 -3.1 2.9
Heart attack 0.3 0.4 0.5 -0.5 0.7 -0.6
Allergy 12.9 29.8 36.8 5.1 -6.1 5.2
Pain all over the body in last month 1.1 1.2 1.3 1.0 -1.1 1.1
Diabetes (self-reported) 3.5 5.3 6.1 -2.5 2.3 -2.1
Hayfever/allergic rhinitis (self-reported) 10.7 14.2 14.7 -3.7 3.8 -3.8
Medication: Ramipril 5.8 7.4 9.8 -2.4 3.1 -2.6
Medication: Simvastatin 0.2 0.3 0.6 -0.4 0.8 -0.4
Fluid intelligence score 0.2 0.5 0.9 -0.6 0.5 -0.9
Illnesses of siblings 0.4 0.6 1.3 0.1 -1.1 0.7
Neuroticism score 0.2 0.3 0.6 -0.4 0.4 -0.8
Weight 0.0 0.2 0.4 0.7 0.2 0.4
Impedance of arm (right) 1.1 5.2 9.7 1.5 -3.1 1.9
Arm fat percentage (right) 0.2 0.7 0.8 -0.8 0.9 -0.8
Trunk fat-free mass 0.3 1.5 2.8 1.7 -0.4 1.2
Hip circumference 0.0 0.2 0.3 0.4 -0.0 0.6
Time employed in main current job 0.0 0.0 0.1 0.1 -0.3 0.2
Alcohol intake versus 10 years previously 2.1 3.2 3.6 -1.5 1.9 -1.9
Father’s age at death 0.9 1.2 1.6 -1.3 0.9 -1.1
Worrier / anxious feelings 0.1 0.1 0.2 -0.5 0.1 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.3 0.6 0.2 0.1
Falls in the last year 1.1 1.5 2.0 1.0 -1.2 1.4
Hair/balding pattern: Pattern 3 1.9 2.8 3.9 2.0 -1.2 1.7
Number of live births 11.8 16.8 19.2 -3.9 4.4 -4.0
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.2 -0.4 0.2 -0.2
Pulse rate 0.5 0.9 1.3 -0.8 1.2 -0.8
Happiness 0.1 0.1 0.2 0.5 0.4 -0.2
Noisy workplace 0.1 0.1 0.2 -0.5 0.0 -0.0
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.6 0.8 -0.7 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.7 0.8 -0.7 0.6
Mouth/teeth dental problems: Dentures 3.1 5.2 6.4 -1.8 2.4 -2.5
Asthma 3.7 7.2 9.3 -2.4 3.1 -2.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.0 -0.7 1.0 -0.5
Medication: Cholesterol lowering 1.0 1.5 2.1 -1.0 1.5 -1.3
Depression (self-reported) 0.2 0.3 0.4 0.4 -0.6 0.5
Medication: Lansoprazole 2.4 2.7 3.6 -1.9 1.6 -1.4
Prospective memory result 0.1 0.1 0.2 0.1 -0.4 0.3
Lung cancer (father) 2.7 3.2 4.3 -1.0 2.1 -2.0
Illnesses of mother 0.0 0.0 0.1 -0.3 0.0 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.1 -0.4 0.3 -0.2
Pulse wave Arterial Stiffness index 0.6 0.6 0.9 -0.9 0.8 -0.7
Impedance of arm (left) 1.4 6.3 11.3 1.7 -3.4 2.1
Arm fat mass (right) 0.1 0.4 0.8 -0.4 0.9 -0.5
Trunk predicted mass 0.3 1.7 3.2 1.8 -0.5 1.3
Standing height 1.3 13.0 14.5 3.8 -3.5 3.5
Length of working week for main job 0.4 0.5 0.8 0.9 -0.6 0.5
Exposure to tobacco smoke at home 0.4 0.5 0.6 -0.8 0.7 -0.5
Breastfed as a baby 0.3 0.4 0.6 -0.8 0.5 -0.6
Tense / ‘highly strung’ 2.3 3.8 5.0 2.2 -2.1 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.1 0.2 -0.4 0.2 -0.1
Hair/balding pattern: Pattern 4 2.4 5.8 7.2 2.1 -2.7 2.4
Birth weight of first child 3.4 6.2 6.9 2.3 -2.6 2.5
Peak expiratory flow (PEF) 0.0 0.1 0.1 0.4 0.3 -0.0
Pulse wave reflection index 0.6 0.8 0.9 -0.9 0.8 -0.9
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.1 -0.4 0.8 -1.0
Loud music exposure frequency 0.1 0.1 0.2 0.2 -0.4 0.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 -0.3 -0.1 -0.4
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 2.8 1.5 -1.3 1.7
Blood clot in the leg (DVT) 0.7 0.9 1.2 1.1 -0.6 1.0
Medication: Paracetamol 0.8 1.3 1.6 -1.1 1.3 -1.0
Headache pain in last month 3.8 6.5 7.6 -2.3 2.8 -2.6
Medication for cholesterol, blood pressure or diabetes 1.4 2.4 4.0 1.1 -2.0 1.3
Glaucoma (self-reported) 2.0 2.4 2.9 1.4 -1.7 1.5
Gout (self-reported) 3.0 4.1 6.7 -1.5 2.6 -1.8
Hypothyroidism/myxoedema (self-reported) 2.1 4.0 5.4 -2.3 2.0 -1.7
Medication: Amlodipine 1.3 1.8 3.0 -1.0 1.7 -1.2
Medication: Ventolin 100micrograms inhaler 0.0 0.0 0.1 -0.1 0.3 -0.1
Birth weight 10.2 22.2 23.1 4.8 -4.6 4.7
Chronic bronchitis/emphysema (mother) 1.7 1.9 2.7 -0.9 1.5 -1.6
High blood pressure (siblings) 0.9 1.2 2.5 1.6 -0.5 1.0
Forced vital capacity (FVC), Best measure 0.2 0.6 0.8 0.6 -0.7 0.9
Body fat percentage 0.3 1.3 1.4 -1.1 1.2 -1.1
Leg fat percentage (right) 0.9 3.2 3.9 -1.7 2.0 -1.7
Arm fat-free mass (right) 0.1 0.4 0.6 0.8 0.6 0.3
Exposure to tobacco smoke outside home 0.1 0.2 0.4 -0.6 -0.0 -0.4
Comparative body size at age 10 1.2 3.3 4.6 2.1 -1.5 1.7
Number of full brothers 0.1 0.2 0.4 0.1 0.6 -0.4
Worry too long after embarrassment 0.6 1.1 1.4 -1.2 0.7 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 2.7 1.2 -1.3 1.6
Wheeze or whistling in the chest in last year 0.5 0.8 1.6 -0.7 1.3 -0.6
Number of children fathered 0.8 0.9 1.3 -0.5 1.1 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.6 4.4 1.1 -2.1 1.5
Age at first live birth 0.9 1.6 2.6 0.9 -1.6 1.2
Pulse wave peak to peak time 0.7 0.8 1.1 1.1 -0.9 0.8
Health satisfaction 0.9 1.1 2.1 1.4 -0.5 1.0
Shortness of breath walking on level ground 0.6 0.8 1.6 1.3 -0.4 0.7
Qualifications: College or University degree 0.6 2.0 2.6 1.3 -1.3 1.6
Eye problems/disorders: None of the above 0.2 0.2 0.3 -0.5 0.3 -0.6
Mouth/teeth dental problems: Loose teeth 0.0 0.1 0.1 0.3 -0.1 -0.3
Emphysema/chronic bronchitis 0.1 0.1 0.1 0.3 0.2 0.4
Medication for pain relief, constipation, heartburn 1.7 2.9 4.3 1.5 -2.1 1.5
Neck or shoulder pain in last month 0.1 0.2 0.2 -0.3 0.4 -0.5
Medication: Blood pressure 1.0 1.8 3.6 -0.8 1.9 -1.0
Angina (self-reported) 0.1 0.1 0.2 0.1 0.5 -0.2
Migraine (self-reported) 0.5 0.7 0.8 -0.9 0.7 -0.8
Medication: Ibuprofen 1.6 1.9 3.0 -1.1 1.7 -1.2
Medication: Allopurinol 1.1 1.5 2.4 -1.1 1.5 -1.0
Medication: Omeprazole 0.4 0.5 1.1 0.5 -0.3 1.1
Medication: Seretide 50 evohaler 1.7 2.0 2.3 1.4 -1.2 1.5
Mean time to correctly identify matches 0.0 0.1 0.1 -0.2 -0.3 -0.4
Heart disease (mother) 0.5 0.6 1.4 1.2 -0.4 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.1 4.9 5.5 -2.2 2.0 -2.3
Whole body fat mass 0.1 0.3 0.6 -0.3 0.8 -0.5
Leg fat mass (right) 0.2 0.9 1.7 -0.7 1.3 -0.8
Arm predicted mass (right) 0.1 0.3 0.5 0.6 0.7 0.2
Pulse rate, automated reading 0.1 0.5 0.7 -0.8 0.8 -0.3
Alcohol intake frequency. 6.1 14.3 18.1 -3.3 4.3 -3.8
Comparative height size at age 10 1.9 10.7 12.6 3.5 -3.2 3.0
Number of full sisters 3.1 3.8 4.2 -2.0 1.9 -1.9
Suffer from ‘nerves’ 0.1 0.1 0.3 -0.1 0.3 -0.6
Overall health rating 0.1 0.2 0.6 -0.1 0.8 -0.1
Chest pain or discomfort 0.1 0.1 0.3 -0.2 0.5 -0.0
Had major operations 6.6 7.8 9.1 -2.5 3.0 -2.8
Age at last live birth 0.5 0.8 1.4 0.5 -1.2 0.8
Family relationship satisfaction 2.0 2.4 2.9 -1.3 1.7 -1.7
Leg pain on walking 0.9 1.2 2.1 1.4 -0.6 1.0
Qualifications: NVQ or HND or HNC or equivalent 2.9 3.5 4.0 -2.0 1.7 -1.8
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.6 0.1 0.3
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.4 -0.4 0.3
Medication: Aspirin 0.8 1.1 1.6 -0.6 1.2 -1.3
Supplements: Vitamin C 0.7 0.8 0.9 -0.9 0.9 -0.8
Knee pain experienced in last month 0.0 0.1 0.2 -0.1 0.4 -0.0
Hypertension (Self-reported) 1.1 3.0 6.3 -0.9 2.5 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 0.8 -0.8 0.9 -0.7
Illnesses of father: Heart disease 0.1 0.1 0.3 -0.5 -0.3 0.1
Illnesses of siblings: Diabetes 3.9 4.8 6.0 -1.7 2.5 -2.3
Smoking status: Previous 0.2 0.4 0.6 -0.1 0.7 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.6 4.3 1.5 -2.1 2.0
Whole body fat-free mass 0.3 1.5 2.7 1.6 -0.4 1.2
Leg fat-free mass (right) 0.5 2.7 3.8 2.0 -1.1 1.7
Arm fat percentage (left) 0.1 0.2 0.3 -0.5 0.6 -0.4
Average weekly red wine intake 1.2 1.8 2.8 0.8 -1.7 1.4
Handedness (chirality/laterality): Left-handed 5.8 7.0 7.7 -2.7 2.8 -2.4
Mood swings 0.1 0.1 0.2 0.0 0.5 -0.4
Loneliness, isolation 0.3 0.4 0.4 -0.6 0.5 -0.7
Long-standing illness, disability or infirmity 0.1 0.2 0.6 -0.3 0.7 -0.1
Ever had bowel cancer screening 0.1 0.1 0.2 -0.2 0.1 -0.4
Diabetes diagnosed by doctor 6.0 9.9 11.8 -3.4 3.1 -2.9
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.8 -0.9 0.2 -0.3
Friendships satisfaction 0.2 0.2 0.4 -0.5 0.4 -0.6
Qualifications: nursing, teaching 0.1 0.1 0.1 0.4 0.3 -0.1
Commuting to job workplace: Walk 0.3 0.3 0.5 -0.7 -0.1 -0.6
Eye problems/disorders: Cataract 0.0 0.0 0.0 0.0 0.0 0.2
Mouth/teeth dental problems: Mouth ulcers 10.8 17.2 18.5 -4.2 4.3 -4.0
Medication for cholesterol 0.4 0.6 1.8 0.2 -1.3 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 2.7 -1.1 1.6 -1.1
Back pain experienced in last month 0.2 0.2 0.5 -0.2 -0.4 0.7
Mineral and other dietary supplements 0.1 0.1 0.3 0.1 -0.5 0.3
Breast cancer (self-reported) 0.1 0.1 0.1 -0.4 0.2 -0.3
Asthma (self-reported) 4.9 9.9 12.3 -2.8 3.5 -3.1
Osteoporosis (self-reported) 0.3 0.3 0.5 0.4 -0.5 0.7
Osteoarthritis (self-reported) 0.2 0.2 0.4 -0.6 0.5 -0.3
Medication: Aspirin 0.7 0.9 1.3 -0.4 1.1 -1.1
Medication: Gliclazide 3.4 3.9 4.9 -1.5 2.2 -2.1
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 0.7 -0.4 0.2
Smoking status: Current 0.1 0.1 0.2 -0.5 0.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.2 4.6 5.0 -2.2 2.0 -2.1
Whole body water mass 0.2 1.4 2.6 1.6 -0.4 1.2
Leg predicted mass (right) 0.5 2.8 4.0 2.0 -1.2 1.8
Arm fat mass (left) 0.1 0.3 0.6 -0.3 0.8 -0.4
Number of self-reported non-cancer illnesses 3.0 5.2 7.1 -1.9 2.7 -2.2
Average weekly champagne plus white wine intake 0.6 0.8 1.3 1.1 -0.7 0.8
Miserableness 0.0 0.1 0.1 -0.2 -0.4 -0.2
Guilty feelings 0.1 0.2 0.6 0.8 -0.1 0.2
Wears glasses or contact lenses 0.1 0.1 0.1 -0.4 -0.0 -0.3
Ever taken oral contraceptive pill 0.1 0.2 0.2 -0.3 0.5 -0.4
Hearing aid user 3.6 4.1 4.5 -2.1 2.1 -1.8
Mother’s age at death 0.1 0.2 0.5 -0.7 0.1 -0.1
Financial situation satisfaction 0.1 0.1 0.2 -0.1 0.5 -0.5
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 -0.4 0.3 -0.1
Commuting to job workplace: Public transport 0.0 0.0 0.0 -0.2 -0.1 -0.1
Eye problems/disorders: Glaucoma 2.1 2.5 2.7 1.5 -1.6 1.5
Medication: Blood pressure 0.4 0.7 2.0 -0.3 1.4 -0.4
Pain type(s) experienced in last month: Hip pain 2.0 2.5 3.3 1.4 -1.4 1.8
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 0.5 -0.2 0.6
High cholesterol (Self-reported) 1.0 1.7 2.7 1.6 -0.9 1.3
Medication: Bendroflumethiazide 0.3 0.4 0.7 0.8 0.2 0.7
Medication: Paracetamol 1.0 1.6 1.9 -1.2 1.4 -1.2
Medication: Lisinopril 0.1 0.2 0.4 0.4 -0.2 0.6
Medication: Atorvastatin 0.3 0.4 0.7 0.7 -0.2 0.8
Illnesses of father: High blood pressure 0.2 0.3 0.6 0.5 -0.1 0.8
Alcohol drinker status: Never 0.9 1.1 2.3 -0.6 1.5 -0.8
Ever smoked 0.5 0.8 1.4 -0.4 1.0 -1.2
Basal metabolic rate 0.2 1.0 1.8 1.4 -0.2 1.0
Leg fat percentage (left) 1.0 3.5 4.3 -1.8 2.1 -1.8
Arm fat-free mass (left) 0.1 0.4 1.0 0.4 1.0 -0.1
Number of operations (self-reported) 7.1 10.5 12.6 -3.0 3.5 -3.1
Average weekly beer plus cider intake 0.1 0.1 0.3 0.1 -0.5 0.0
Irritability 0.2 0.3 0.3 0.5 -0.6 0.5
Risk taking 0.3 0.4 0.9 -0.3 0.5 -0.9
Ever had prostate specific antigen (PSA) test 1.2 1.4 1.8 1.3 -0.9 1.4
Fractured/broken bones in last 5 years 0.0 0.0 0.0 0.2 0.1 0.1
Age started oral contraceptive pill 0.1 0.1 0.1 -0.4 0.2 -0.3
Diastolic blood pressure, automated reading 1.0 3.2 6.6 -1.2 2.6 -1.3
Ever depressed for a whole week 0.9 1.1 1.4 -0.9 1.2 -1.1
Unable to work because of sickness or disability 0.0 0.0 0.1 0.2 0.2 0.2
Commuting to job workplace: Cycle 0.8 1.0 1.4 1.2 -0.8 0.9
Myopia 0.6 0.9 1.4 -1.2 0.5 -1.0
Vascular/heart problems diagnosed by doctor 1.2 3.4 6.8 1.0 -2.6 1.5
Cholesterol lowering medication 0.5 0.8 1.3 0.9 -0.5 1.2
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 -0.2 0.4 0.5
Pain experienced in last month 1.5 2.5 3.1 1.6 -1.8 1.3
Supplements: Calcium 1.5 1.6 2.2 -0.8 1.5 -1.4
Basal cell carcinoma (self-reported) 0.0 0.1 0.1 -0.1 0.4 -0.1
Heart attack/myocardial infarction (self-reported) 0.0 0.1 0.1 -0.1 0.3 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 0.9 1.0 -0.5 0.9
Heart disease (siblings) 0.3 0.4 0.6 -0.2 0.8 -0.8
Alcohol drinker status: Previous 0.8 0.9 1.7 -0.5 1.3 -0.9
Pack years of smoking 0.2 0.4 0.8 0.5 0.9 0.2
Impedance of whole body 0.3 1.4 3.4 0.4 -1.9 0.8
Leg fat mass (left) 0.3 1.2 2.1 -0.8 1.5 -0.9
Arm predicted mass (left) 0.1 0.3 0.9 0.4 0.9 -0.1