Hub : Genes

NFKB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0364	0.0136	2.8e-06	0.029	0.018	0.022	0.025	0.026	7.2e-10	1.0e-06	7.9e-08	1.2e-08	5.4e-09
2	TCGA	Testicular Germ Cell Tumors	0.1000	0.0510	6.1e-04	0.057	0.067	0.003	NA	0.043	4.5e-03	2.2e-03	2.5e-01	NA	1.2e-02
3	TCGA	Thyroid Carcinoma	0.0640	0.0270	4.4e-08	0.085	0.082	0.086	NA	0.082	1.1e-08	2.0e-08	9.1e-09	NA	2.1e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	0.7	-0.6	0.8	-0.8
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.3	-0.4	0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.4	0.5	-0.5
Depression (Nagel 2018)	0.0	0.0	0.1	0.0	0.3	0.1
Intelligence (Savage-Jansen 2018)	0.7	2.1	3.6	1.9	-1.4	0.8
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.2	-0.0	0.1
Schizophrenia (2018)	0.5	1.0	1.3	0.8	-1.1	1.0
Schizophrenia vs Biploar Disorder	0.7	0.9	1.4	0.7	-1.2	1.0
Worry (Nagel 2018)	1.0	2.2	2.7	1.5	-1.6	1.3
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.1	0.1	-0.2
Alzheimer’s Disease (in father)	0.1	0.2	0.3	0.5	-0.2	0.4
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.3	-0.1	0.1
Crohns Disease (2017)	7.6	16.7	19.7	-4.4	4.1	-3.7
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	-0.4	0.0	0.1
Ulcerative Colitis (UC)	6.3	11.9	13.5	3.3	-3.7	3.4
Major Depression (MDD)	0.2	0.3	0.6	0.8	-0.5	0.2
Reaction Time	0.1	0.2	0.5	0.2	-0.7	0.2
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.2	0.3	-0.4
Breast Cancer	0.0	0.1	0.2	-0.1	0.0	-0.5
Ovarian Cancer	0.1	0.2	0.2	-0.5	0.4	-0.4
Prostate Cancer	0.2	0.3	0.5	0.3	-0.7	0.5
Age at First Birth	2.1	3.0	4.7	-2.2	1.6	-1.4
Bipolar Disorder (2011)	0.5	0.5	0.6	-0.6	0.8	-0.8
Body Mass Index (BMI) (2010)	0.1	0.1	0.1	0.1	0.4	0.4
Coronary Artery Disease (CAD)	0.8	1.0	1.2	1.1	-1.1	0.7
Crohns Disease (2012)	2.5	4.0	4.7	-2.2	2.2	-1.6
Mean Putamen Volume	0.2	0.3	0.8	-0.9	0.1	0.0
Fasting Glucose	2.7	3.2	5.0	-1.4	2.2	-1.6
HbA1C	1.8	2.0	3.0	-1.6	1.7	-0.7
HDL Cholesterol	3.0	5.0	5.9	2.4	-2.2	2.1
LDL Cholesterol	0.5	0.8	1.2	1.1	-0.6	0.9
Lupus	0.1	0.1	0.2	0.5	-0.3	0.2
Neuroticism (2016)	0.3	0.5	1.0	1.0	-0.5	0.4
Primary Biliary Cirrhosis	20.9	29.8	36.4	4.8	-6.0	5.5
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.2	0.4	0.7	0.4	-0.9	0.6
Triglycerides	1.3	2.1	3.2	1.1	-1.4	1.8
Type 2 Diabetes (T2D) (2012)	5.9	6.9	9.1	-2.4	3.0	-2.4
Ulcerative Colitis	9.0	13.1	14.4	3.5	-3.8	3.6
Blood Eosinophil Count	1.9	14.7	16.5	3.4	-4.1	4.0
Blood Platelet Count	0.8	9.3	11.0	-3.2	2.6	-3.3
Blood Red Count	4.7	45.1	47.5	-6.6	6.9	-6.7
Blood White Count	0.2	1.3	2.5	0.7	-1.6	1.0
Heel T-Score	0.0	0.1	0.2	0.1	-0.4	-0.3
BMI	0.1	0.6	1.6	-0.2	1.3	-0.1
Height	1.3	25.0	28.0	5.3	-4.8	4.8
Waist Hip Ratio (WHR)	0.3	1.3	1.8	0.8	-1.3	1.1
Systolic Blood Pressure	0.3	1.6	2.7	1.6	-0.9	1.2
Smoking Status	0.0	0.0	0.0	0.1	0.0	0.0
Allergy or Eczema	19.9	52.4	61.5	-6.8	7.8	-7.1
Cardiovascular Disease	0.3	1.0	2.8	-0.0	1.7	-0.3
Hypothyroidism (self reported)	0.3	0.6	0.8	-0.8	0.9	-0.6
Respiratory disease	3.0	6.6	9.3	-2.1	3.0	-2.4
Type 2 Diabetes (T2D) (2018)	2.6	4.8	6.0	-2.4	2.0	-2.1
Lung FEV1/FVC ratio	2.2	11.4	12.0	-3.5	3.2	-3.5
Lung FVC	0.5	2.5	4.5	-2.1	1.1	-1.4
Neuroticism	0.0	0.0	0.0	0.2	0.0	-0.1
Chronotype (morning person)	0.2	0.6	1.4	-0.0	1.2	-0.5
Hair Pigment	0.1	1.9	3.0	1.4	-0.9	1.7
Tanning	0.2	1.9	2.6	-1.6	1.0	-1.4
Hand grip strength (left)	2.2	5.8	7.0	2.6	-1.9	2.6
Number of treatments/medications taken	3.1	5.5	9.3	-1.7	3.1	-2.1
Average weekly spirits intake	1.9	2.4	3.2	-1.8	1.4	-1.4
Sensitivity / hurt feelings	0.3	0.6	1.0	-0.1	1.0	-0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	-0.3	0.8	-0.5
Hearing difficulty/problems: Yes	5.7	8.7	9.5	-3.1	3.0	-2.7
Relative age of first facial hair	0.7	1.4	2.3	0.8	-1.5	1.1
Other serious medical condition/disability diagnosed by doctor	3.7	4.8	5.4	2.0	-2.3	2.3
Ever used hormone-replacement therapy (HRT)	3.1	3.9	5.9	-1.3	2.4	-2.0
Ever had hysterectomy (womb removed)	0.2	0.3	0.6	-0.2	0.8	-0.4
Systolic blood pressure, automated reading	0.2	0.4	0.6	-0.5	0.8	-0.7
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	2.5	-1.3	1.6	-1.3
Angina	0.1	0.1	0.1	0.3	0.4	-0.1
Medication for hormone replacement therapy	2.3	2.6	2.8	-1.5	1.7	-1.6
Vitamin and mineral supplements	1.7	2.3	2.4	1.5	-1.5	1.5
Supplements: Zinc	0.0	0.0	0.0	-0.1	0.2	-0.2
Medication: Co-codamol	0.0	0.0	0.0	0.2	-0.2	0.2
Medication: Metformin	4.6	6.5	7.3	-2.6	2.7	-2.4
Diabetes (father)	0.2	0.2	0.5	0.3	-0.2	0.7
Diabetes (mother)	1.6	2.1	2.5	-1.5	1.6	-1.3
Severe depression (siblings)	0.8	0.9	1.1	1.1	-0.8	1.0
Pack years adult smoking proportion	0.2	0.3	0.4	0.7	0.6	0.4
Impedance of leg (right)	0.1	0.5	1.1	-1.0	-0.0	-0.7
Leg fat-free mass (left)	0.3	1.8	2.8	1.7	-0.8	1.4
Trunk fat percentage	0.3	1.0	1.1	-1.0	1.0	-1.0
Hand grip strength (right)	2.0	5.6	7.1	2.7	-2.0	2.4
Townsend deprivation index at recruitment	0.2	0.3	0.4	-0.6	0.5	-0.5
Current tobacco smoking	0.2	0.3	0.6	-0.8	0.4	-0.5
Average weekly fortified wine intake	0.6	0.7	0.9	-0.9	0.7	-0.9
Maternal smoking around birth	1.0	1.5	3.0	0.1	1.7	-1.2
Fed-up feelings	1.5	2.8	3.4	-1.7	1.9	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	-0.3	1.1	-0.7
Relative age voice broke	1.2	1.9	2.7	0.9	-1.6	1.5
Taking other prescription medications	2.4	3.8	6.1	-1.6	2.5	-1.6
Age when periods started (menarche)	6.8	16.3	19.9	-4.5	3.5	-4.1
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.1	-0.7	1.4	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.6	0.4	-1.6	1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	0.8	0.9	-0.9	0.6
Qualifications: CSEs or equivalent	0.0	0.1	0.1	-0.1	0.3	-0.3
Serious illness, injury or assault to yourself	0.3	0.4	0.8	0.4	-0.4	0.9
High blood pressure	0.8	2.1	5.0	-0.6	2.2	-1.0
Hayfever, allergic rhinitis or eczema	16.8	36.4	42.6	-5.7	6.5	-5.8
Multivitamins +/- minerals	2.8	3.6	3.6	-1.9	1.9	-1.9
Stomach or abdominal pain in last month	0.0	0.0	0.0	0.0	-0.0	0.1
Supplements: Glucosamine	1.0	1.3	1.6	-1.3	1.1	-1.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.3	-0.3	0.0
Medication: Atenolol	0.6	0.8	1.1	-0.5	1.0	-1.0
Medication: Levothyroxine sodium	1.1	1.8	2.4	-1.5	1.3	-1.2
Sitting height	2.1	14.7	17.1	4.1	-3.5	3.8
Chronic bronchitis/emphysema (father)	1.8	2.1	2.7	-1.6	1.5	-1.2
High blood pressure (mother)	0.1	0.1	0.3	-0.1	0.6	-0.3
Body mass index (BMI)	0.6	2.6	4.0	-1.3	2.0	-1.4
Impedance of leg (left)	0.1	0.4	0.9	-0.9	-0.1	-0.5
Leg predicted mass (left)	0.3	1.7	2.7	1.6	-0.7	1.4
Trunk fat mass	0.0	0.2	0.3	-0.2	0.6	-0.4
Waist circumference	0.0	0.1	0.1	-0.1	0.4	0.1
Number of incorrect matches in round	0.9	1.5	2.2	-1.5	1.2	-0.9
Past tobacco smoking	0.1	0.3	0.4	-0.3	-0.5	0.6
Alcohol usually taken with meals	0.0	0.1	0.1	-0.2	-0.3	0.1
Nervous feelings	2.8	5.2	6.6	2.2	-2.6	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	0.2	-0.3	0.1
Hearing difficulty/problems with background noise	0.9	1.5	1.6	-1.1	1.3	-1.2
Hair/balding pattern: Pattern 2	1.4	1.8	2.0	-1.3	1.3	-1.4
Had menopause	1.8	2.2	2.6	-1.3	1.6	-1.5
Had other major operations	1.6	1.9	2.5	-1.4	1.6	-1.2
Forced vital capacity (FVC)	0.2	0.6	0.9	0.6	-0.8	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	0.4	-0.8	0.4
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	2.8	-1.7	1.4	-1.6
Qualifications: None of the above	2.2	4.8	5.4	-2.0	2.2	-2.3
Financial difficulties in last 2 years	0.7	1.0	1.9	1.4	-0.8	0.7
Mouth/teeth dental problems	4.8	7.3	9.4	2.0	-3.1	2.9
Heart attack	0.3	0.4	0.5	-0.5	0.7	-0.6
Allergy	12.9	29.8	36.8	5.1	-6.1	5.2
Pain all over the body in last month	1.1	1.2	1.3	1.0	-1.1	1.1
Diabetes (self-reported)	3.5	5.3	6.1	-2.5	2.3	-2.1
Hayfever/allergic rhinitis (self-reported)	10.7	14.2	14.7	-3.7	3.8	-3.8
Medication: Ramipril	5.8	7.4	9.8	-2.4	3.1	-2.6
Medication: Simvastatin	0.2	0.3	0.6	-0.4	0.8	-0.4
Fluid intelligence score	0.2	0.5	0.9	-0.6	0.5	-0.9
Illnesses of siblings	0.4	0.6	1.3	0.1	-1.1	0.7
Neuroticism score	0.2	0.3	0.6	-0.4	0.4	-0.8
Weight	0.0	0.2	0.4	0.7	0.2	0.4
Impedance of arm (right)	1.1	5.2	9.7	1.5	-3.1	1.9
Arm fat percentage (right)	0.2	0.7	0.8	-0.8	0.9	-0.8
Trunk fat-free mass	0.3	1.5	2.8	1.7	-0.4	1.2
Hip circumference	0.0	0.2	0.3	0.4	-0.0	0.6
Time employed in main current job	0.0	0.0	0.1	0.1	-0.3	0.2
Alcohol intake versus 10 years previously	2.1	3.2	3.6	-1.5	1.9	-1.9
Father’s age at death	0.9	1.2	1.6	-1.3	0.9	-1.1
Worrier / anxious feelings	0.1	0.1	0.2	-0.5	0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.6	0.2	0.1
Falls in the last year	1.1	1.5	2.0	1.0	-1.2	1.4
Hair/balding pattern: Pattern 3	1.9	2.8	3.9	2.0	-1.2	1.7
Number of live births	11.8	16.8	19.2	-3.9	4.4	-4.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.4	0.2	-0.2
Pulse rate	0.5	0.9	1.3	-0.8	1.2	-0.8
Happiness	0.1	0.1	0.2	0.5	0.4	-0.2
Noisy workplace	0.1	0.1	0.2	-0.5	0.0	-0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.6	0.8	-0.7	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.7	0.8	-0.7	0.6
Mouth/teeth dental problems: Dentures	3.1	5.2	6.4	-1.8	2.4	-2.5
Asthma	3.7	7.2	9.3	-2.4	3.1	-2.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	-0.7	1.0	-0.5
Medication: Cholesterol lowering	1.0	1.5	2.1	-1.0	1.5	-1.3
Depression (self-reported)	0.2	0.3	0.4	0.4	-0.6	0.5
Medication: Lansoprazole	2.4	2.7	3.6	-1.9	1.6	-1.4
Prospective memory result	0.1	0.1	0.2	0.1	-0.4	0.3
Lung cancer (father)	2.7	3.2	4.3	-1.0	2.1	-2.0
Illnesses of mother	0.0	0.0	0.1	-0.3	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	-0.4	0.3	-0.2
Pulse wave Arterial Stiffness index	0.6	0.6	0.9	-0.9	0.8	-0.7
Impedance of arm (left)	1.4	6.3	11.3	1.7	-3.4	2.1
Arm fat mass (right)	0.1	0.4	0.8	-0.4	0.9	-0.5
Trunk predicted mass	0.3	1.7	3.2	1.8	-0.5	1.3
Standing height	1.3	13.0	14.5	3.8	-3.5	3.5
Length of working week for main job	0.4	0.5	0.8	0.9	-0.6	0.5
Exposure to tobacco smoke at home	0.4	0.5	0.6	-0.8	0.7	-0.5
Breastfed as a baby	0.3	0.4	0.6	-0.8	0.5	-0.6
Tense / ‘highly strung’	2.3	3.8	5.0	2.2	-2.1	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.2	-0.4	0.2	-0.1
Hair/balding pattern: Pattern 4	2.4	5.8	7.2	2.1	-2.7	2.4
Birth weight of first child	3.4	6.2	6.9	2.3	-2.6	2.5
Peak expiratory flow (PEF)	0.0	0.1	0.1	0.4	0.3	-0.0
Pulse wave reflection index	0.6	0.8	0.9	-0.9	0.8	-0.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	-0.4	0.8	-1.0
Loud music exposure frequency	0.1	0.1	0.2	0.2	-0.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.3	-0.1	-0.4
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	2.8	1.5	-1.3	1.7
Blood clot in the leg (DVT)	0.7	0.9	1.2	1.1	-0.6	1.0
Medication: Paracetamol	0.8	1.3	1.6	-1.1	1.3	-1.0
Headache pain in last month	3.8	6.5	7.6	-2.3	2.8	-2.6
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	4.0	1.1	-2.0	1.3
Glaucoma (self-reported)	2.0	2.4	2.9	1.4	-1.7	1.5
Gout (self-reported)	3.0	4.1	6.7	-1.5	2.6	-1.8
Hypothyroidism/myxoedema (self-reported)	2.1	4.0	5.4	-2.3	2.0	-1.7
Medication: Amlodipine	1.3	1.8	3.0	-1.0	1.7	-1.2
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	-0.1	0.3	-0.1
Birth weight	10.2	22.2	23.1	4.8	-4.6	4.7
Chronic bronchitis/emphysema (mother)	1.7	1.9	2.7	-0.9	1.5	-1.6
High blood pressure (siblings)	0.9	1.2	2.5	1.6	-0.5	1.0
Forced vital capacity (FVC), Best measure	0.2	0.6	0.8	0.6	-0.7	0.9
Body fat percentage	0.3	1.3	1.4	-1.1	1.2	-1.1
Leg fat percentage (right)	0.9	3.2	3.9	-1.7	2.0	-1.7
Arm fat-free mass (right)	0.1	0.4	0.6	0.8	0.6	0.3
Exposure to tobacco smoke outside home	0.1	0.2	0.4	-0.6	-0.0	-0.4
Comparative body size at age 10	1.2	3.3	4.6	2.1	-1.5	1.7
Number of full brothers	0.1	0.2	0.4	0.1	0.6	-0.4
Worry too long after embarrassment	0.6	1.1	1.4	-1.2	0.7	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	2.7	1.2	-1.3	1.6
Wheeze or whistling in the chest in last year	0.5	0.8	1.6	-0.7	1.3	-0.6
Number of children fathered	0.8	0.9	1.3	-0.5	1.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	4.4	1.1	-2.1	1.5
Age at first live birth	0.9	1.6	2.6	0.9	-1.6	1.2
Pulse wave peak to peak time	0.7	0.8	1.1	1.1	-0.9	0.8
Health satisfaction	0.9	1.1	2.1	1.4	-0.5	1.0
Shortness of breath walking on level ground	0.6	0.8	1.6	1.3	-0.4	0.7
Qualifications: College or University degree	0.6	2.0	2.6	1.3	-1.3	1.6
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.5	0.3	-0.6
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.1	0.3	-0.1	-0.3
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.3	0.2	0.4
Medication for pain relief, constipation, heartburn	1.7	2.9	4.3	1.5	-2.1	1.5
Neck or shoulder pain in last month	0.1	0.2	0.2	-0.3	0.4	-0.5
Medication: Blood pressure	1.0	1.8	3.6	-0.8	1.9	-1.0
Angina (self-reported)	0.1	0.1	0.2	0.1	0.5	-0.2
Migraine (self-reported)	0.5	0.7	0.8	-0.9	0.7	-0.8
Medication: Ibuprofen	1.6	1.9	3.0	-1.1	1.7	-1.2
Medication: Allopurinol	1.1	1.5	2.4	-1.1	1.5	-1.0
Medication: Omeprazole	0.4	0.5	1.1	0.5	-0.3	1.1
Medication: Seretide 50 evohaler	1.7	2.0	2.3	1.4	-1.2	1.5
Mean time to correctly identify matches	0.0	0.1	0.1	-0.2	-0.3	-0.4
Heart disease (mother)	0.5	0.6	1.4	1.2	-0.4	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.1	4.9	5.5	-2.2	2.0	-2.3
Whole body fat mass	0.1	0.3	0.6	-0.3	0.8	-0.5
Leg fat mass (right)	0.2	0.9	1.7	-0.7	1.3	-0.8
Arm predicted mass (right)	0.1	0.3	0.5	0.6	0.7	0.2
Pulse rate, automated reading	0.1	0.5	0.7	-0.8	0.8	-0.3
Alcohol intake frequency.	6.1	14.3	18.1	-3.3	4.3	-3.8
Comparative height size at age 10	1.9	10.7	12.6	3.5	-3.2	3.0
Number of full sisters	3.1	3.8	4.2	-2.0	1.9	-1.9
Suffer from ‘nerves’	0.1	0.1	0.3	-0.1	0.3	-0.6
Overall health rating	0.1	0.2	0.6	-0.1	0.8	-0.1
Chest pain or discomfort	0.1	0.1	0.3	-0.2	0.5	-0.0
Had major operations	6.6	7.8	9.1	-2.5	3.0	-2.8
Age at last live birth	0.5	0.8	1.4	0.5	-1.2	0.8
Family relationship satisfaction	2.0	2.4	2.9	-1.3	1.7	-1.7
Leg pain on walking	0.9	1.2	2.1	1.4	-0.6	1.0
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.5	4.0	-2.0	1.7	-1.8
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.6	0.1	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.4	-0.4	0.3
Medication: Aspirin	0.8	1.1	1.6	-0.6	1.2	-1.3
Supplements: Vitamin C	0.7	0.8	0.9	-0.9	0.9	-0.8
Knee pain experienced in last month	0.0	0.1	0.2	-0.1	0.4	-0.0
Hypertension (Self-reported)	1.1	3.0	6.3	-0.9	2.5	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.8	-0.8	0.9	-0.7
Illnesses of father: Heart disease	0.1	0.1	0.3	-0.5	-0.3	0.1
Illnesses of siblings: Diabetes	3.9	4.8	6.0	-1.7	2.5	-2.3
Smoking status: Previous	0.2	0.4	0.6	-0.1	0.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	4.3	1.5	-2.1	2.0
Whole body fat-free mass	0.3	1.5	2.7	1.6	-0.4	1.2
Leg fat-free mass (right)	0.5	2.7	3.8	2.0	-1.1	1.7
Arm fat percentage (left)	0.1	0.2	0.3	-0.5	0.6	-0.4
Average weekly red wine intake	1.2	1.8	2.8	0.8	-1.7	1.4
Handedness (chirality/laterality): Left-handed	5.8	7.0	7.7	-2.7	2.8	-2.4
Mood swings	0.1	0.1	0.2	0.0	0.5	-0.4
Loneliness, isolation	0.3	0.4	0.4	-0.6	0.5	-0.7
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.3	0.7	-0.1
Ever had bowel cancer screening	0.1	0.1	0.2	-0.2	0.1	-0.4
Diabetes diagnosed by doctor	6.0	9.9	11.8	-3.4	3.1	-2.9
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.9	0.2	-0.3
Friendships satisfaction	0.2	0.2	0.4	-0.5	0.4	-0.6
Qualifications: nursing, teaching	0.1	0.1	0.1	0.4	0.3	-0.1
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.7	-0.1	-0.6
Eye problems/disorders: Cataract	0.0	0.0	0.0	0.0	0.0	0.2
Mouth/teeth dental problems: Mouth ulcers	10.8	17.2	18.5	-4.2	4.3	-4.0
Medication for cholesterol	0.4	0.6	1.8	0.2	-1.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	2.7	-1.1	1.6	-1.1
Back pain experienced in last month	0.2	0.2	0.5	-0.2	-0.4	0.7
Mineral and other dietary supplements	0.1	0.1	0.3	0.1	-0.5	0.3
Breast cancer (self-reported)	0.1	0.1	0.1	-0.4	0.2	-0.3
Asthma (self-reported)	4.9	9.9	12.3	-2.8	3.5	-3.1
Osteoporosis (self-reported)	0.3	0.3	0.5	0.4	-0.5	0.7
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.6	0.5	-0.3
Medication: Aspirin	0.7	0.9	1.3	-0.4	1.1	-1.1
Medication: Gliclazide	3.4	3.9	4.9	-1.5	2.2	-2.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	0.7	-0.4	0.2
Smoking status: Current	0.1	0.1	0.2	-0.5	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	5.0	-2.2	2.0	-2.1
Whole body water mass	0.2	1.4	2.6	1.6	-0.4	1.2
Leg predicted mass (right)	0.5	2.8	4.0	2.0	-1.2	1.8
Arm fat mass (left)	0.1	0.3	0.6	-0.3	0.8	-0.4
Number of self-reported non-cancer illnesses	3.0	5.2	7.1	-1.9	2.7	-2.2
Average weekly champagne plus white wine intake	0.6	0.8	1.3	1.1	-0.7	0.8
Miserableness	0.0	0.1	0.1	-0.2	-0.4	-0.2
Guilty feelings	0.1	0.2	0.6	0.8	-0.1	0.2
Wears glasses or contact lenses	0.1	0.1	0.1	-0.4	-0.0	-0.3
Ever taken oral contraceptive pill	0.1	0.2	0.2	-0.3	0.5	-0.4
Hearing aid user	3.6	4.1	4.5	-2.1	2.1	-1.8
Mother’s age at death	0.1	0.2	0.5	-0.7	0.1	-0.1
Financial situation satisfaction	0.1	0.1	0.2	-0.1	0.5	-0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	-0.4	0.3	-0.1
Commuting to job workplace: Public transport	0.0	0.0	0.0	-0.2	-0.1	-0.1
Eye problems/disorders: Glaucoma	2.1	2.5	2.7	1.5	-1.6	1.5
Medication: Blood pressure	0.4	0.7	2.0	-0.3	1.4	-0.4
Pain type(s) experienced in last month: Hip pain	2.0	2.5	3.3	1.4	-1.4	1.8
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.5	-0.2	0.6
High cholesterol (Self-reported)	1.0	1.7	2.7	1.6	-0.9	1.3
Medication: Bendroflumethiazide	0.3	0.4	0.7	0.8	0.2	0.7
Medication: Paracetamol	1.0	1.6	1.9	-1.2	1.4	-1.2
Medication: Lisinopril	0.1	0.2	0.4	0.4	-0.2	0.6
Medication: Atorvastatin	0.3	0.4	0.7	0.7	-0.2	0.8
Illnesses of father: High blood pressure	0.2	0.3	0.6	0.5	-0.1	0.8
Alcohol drinker status: Never	0.9	1.1	2.3	-0.6	1.5	-0.8
Ever smoked	0.5	0.8	1.4	-0.4	1.0	-1.2
Basal metabolic rate	0.2	1.0	1.8	1.4	-0.2	1.0
Leg fat percentage (left)	1.0	3.5	4.3	-1.8	2.1	-1.8
Arm fat-free mass (left)	0.1	0.4	1.0	0.4	1.0	-0.1
Number of operations (self-reported)	7.1	10.5	12.6	-3.0	3.5	-3.1
Average weekly beer plus cider intake	0.1	0.1	0.3	0.1	-0.5	0.0
Irritability	0.2	0.3	0.3	0.5	-0.6	0.5
Risk taking	0.3	0.4	0.9	-0.3	0.5	-0.9
Ever had prostate specific antigen (PSA) test	1.2	1.4	1.8	1.3	-0.9	1.4
Fractured/broken bones in last 5 years	0.0	0.0	0.0	0.2	0.1	0.1
Age started oral contraceptive pill	0.1	0.1	0.1	-0.4	0.2	-0.3
Diastolic blood pressure, automated reading	1.0	3.2	6.6	-1.2	2.6	-1.3
Ever depressed for a whole week	0.9	1.1	1.4	-0.9	1.2	-1.1
Unable to work because of sickness or disability	0.0	0.0	0.1	0.2	0.2	0.2
Commuting to job workplace: Cycle	0.8	1.0	1.4	1.2	-0.8	0.9
Myopia	0.6	0.9	1.4	-1.2	0.5	-1.0
Vascular/heart problems diagnosed by doctor	1.2	3.4	6.8	1.0	-2.6	1.5
Cholesterol lowering medication	0.5	0.8	1.3	0.9	-0.5	1.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.2	0.4	0.5
Pain experienced in last month	1.5	2.5	3.1	1.6	-1.8	1.3
Supplements: Calcium	1.5	1.6	2.2	-0.8	1.5	-1.4
Basal cell carcinoma (self-reported)	0.0	0.1	0.1	-0.1	0.4	-0.1
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	-0.1	0.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.9	1.0	-0.5	0.9
Heart disease (siblings)	0.3	0.4	0.6	-0.2	0.8	-0.8
Alcohol drinker status: Previous	0.8	0.9	1.7	-0.5	1.3	-0.9
Pack years of smoking	0.2	0.4	0.8	0.5	0.9	0.2
Impedance of whole body	0.3	1.4	3.4	0.4	-1.9	0.8
Leg fat mass (left)	0.3	1.2	2.1	-0.8	1.5	-0.9
Arm predicted mass (left)	0.1	0.3	0.9	0.4	0.9	-0.1