Best TWAS P=7.15e-12 · Best GWAS P=3.84e-09 conditioned to 0.587
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | WDR52 | 0.09 | 0.07 | lasso | 7 | 0.09 | 1.1e-07 | -5.4 | 5.2 | 2.6e-07 | -0.64 | 0.41 | 0.58 | FALSE |
2 | GTEx | Adipose Visceral Omentum | WDR52 | 0.13 | 0.07 | enet | 20 | 0.07 | 2.1e-04 | -5.4 | 5.2 | 1.5e-07 | -0.64 | 0.07 | 0.90 | FALSE |
3 | GTEx | Artery Tibial | WDR52 | 0.07 | 0.08 | lasso | 3 | 0.07 | 2.8e-06 | -5.2 | 5.2 | 2.5e-07 | -0.65 | 0.47 | 0.39 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | WDR52 | 0.22 | -0.01 | lasso | 9 | 0.00 | 3.5e-01 | -3.4 | 5.6 | 2.0e-08 | -0.37 | 0.08 | 0.16 | FALSE |
5 | GTEx | Colon Transverse | WDR52 | 0.27 | 0.07 | enet | 25 | 0.12 | 3.7e-06 | -5.6 | 5.4 | 6.9e-08 | -0.46 | 0.59 | 0.15 | FALSE |
6 | GTEx | Esophagus Mucosa | SIDT1 | 0.36 | 0.31 | enet | 21 | 0.33 | 6.2e-23 | 5.1 | -5.7 | 1.5e-08 | 0.70 | 0.99 | 0.01 | FALSE |
7 | GTEx | Esophagus Muscularis | WDR52 | 0.08 | 0.03 | enet | 14 | 0.03 | 7.5e-03 | -5.7 | 5.5 | 4.6e-08 | -0.51 | 0.09 | 0.75 | FALSE |
8 | GTEx | Nerve Tibial | WDR52 | 0.12 | 0.03 | lasso | 10 | 0.02 | 9.1e-03 | -5.6 | 5.9 | 4.6e-09 | -0.49 | 0.48 | 0.24 | FALSE |
9 | GTEx | Ovary | WDR52 | 0.21 | 0.26 | lasso | 9 | 0.23 | 1.9e-06 | -7.1 | 6.8 | 7.2e-12 | -0.81 | 0.00 | 0.99 | TRUE |
10 | GTEx | Skin Not Sun Exposed Suprapubic | WDR52 | 0.11 | 0.07 | lasso | 13 | 0.11 | 9.0e-07 | -5.2 | 5.7 | 1.1e-08 | -0.41 | 0.74 | 0.09 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | WDR52 | 0.12 | 0.06 | enet | 22 | 0.05 | 1.0e-04 | -5.6 | 5.7 | 1.1e-08 | -0.55 | 0.67 | 0.20 | FALSE |
12 | GTEx | Testis | SPICE1 | 0.24 | 0.01 | lasso | 8 | 0.03 | 2.2e-02 | -4.6 | -5.7 | 1.5e-08 | 0.45 | 0.10 | 0.26 | FALSE |
13 | GTEx | Thyroid | WDR52 | 0.11 | 0.06 | lasso | 9 | 0.09 | 1.2e-07 | -5.6 | 5.7 | 1.2e-08 | -0.51 | 0.91 | 0.08 | FALSE |
14 | NTR | Blood | SIDT1 | 0.04 | 0.05 | lasso | 3 | 0.05 | 5.6e-15 | 5.2 | -5.2 | 2.3e-07 | 0.64 | 0.99 | 0.01 | FALSE |
15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SIDT1 | 0.05 | 0.01 | blup | 87 | 0.03 | 1.1e-04 | 6.6 | -5.8 | 7.2e-09 | 0.75 | 0.04 | 0.89 | FALSE |