Best TWAS P=8.71e-15 · Best GWAS P=6.94e-14 conditioned to 0.679
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | EEFSEC | 0.07 | 0.04 | blup | 496 | 0.04 | 1.2e-05 | 6.78 | -6.7 | 3.0e-11 | -0.72 | 0.04 | 0.96 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | RUVBL1 | 0.04 | 0.00 | bslmm | 434 | 0.03 | 3.6e-04 | -0.78 | -5.2 | 2.0e-07 | -0.52 | 0.09 | 0.14 | FALSE |
3 | GTEx | Adipose Subcutaneous | EEFSEC | 0.07 | 0.03 | enet | 12 | 0.06 | 2.4e-05 | 7.78 | -6.7 | 2.0e-11 | -0.78 | 0.02 | 0.98 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | SEC61A1 | 0.13 | 0.18 | lasso | 2 | 0.17 | 1.0e-12 | 5.36 | 5.2 | 1.8e-07 | 0.66 | 1.00 | 0.00 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | EEFSEC | 0.08 | 0.08 | lasso | 2 | 0.06 | 2.4e-05 | 7.62 | -7.7 | 1.9e-14 | -0.94 | 0.01 | 0.98 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | RUVBL1 | 0.07 | 0.04 | lasso | 3 | 0.02 | 2.5e-02 | 5.82 | 5.8 | 7.1e-09 | 0.52 | 0.72 | 0.20 | FALSE |
7 | GTEx | Esophagus Muscularis | EEFSEC | 0.07 | 0.08 | lasso | 5 | 0.07 | 4.4e-05 | 7.78 | -7.8 | 8.7e-15 | -0.95 | 0.01 | 0.98 | TRUE |
8 | GTEx | Muscle Skeletal | EEFSEC | 0.05 | 0.01 | lasso | 5 | 0.02 | 4.3e-03 | 4.50 | -6.7 | 2.4e-11 | -0.86 | 0.04 | 0.94 | FALSE |
9 | GTEx | Nerve Tibial | EEFSEC | 0.07 | 0.06 | lasso | 2 | 0.06 | 4.5e-05 | 7.76 | -7.7 | 1.1e-14 | -0.94 | 0.01 | 0.99 | FALSE |
10 | GTEx | Testis | RUVBL1 | 0.31 | 0.30 | lasso | 12 | 0.30 | 1.2e-13 | 5.62 | 5.8 | 6.2e-09 | 0.54 | 0.98 | 0.02 | FALSE |
11 | The Cancer Genome Atlas | Glioblastoma Multiforme | EEFSEC | 0.09 | 0.07 | lasso | 10 | 0.05 | 1.7e-02 | 5.72 | -6.4 | 1.5e-10 | -0.65 | 0.09 | 0.25 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EEFSEC | 0.07 | 0.05 | blup | 115 | 0.07 | 1.6e-08 | 7.79 | -7.3 | 2.4e-13 | -0.88 | 0.01 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | EEFSEC | 0.08 | 0.03 | blup | 116 | 0.04 | 1.8e-04 | 5.72 | -6.8 | 8.8e-12 | -0.77 | 0.08 | 0.90 | FALSE |