Hub : Genes

SPICE1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.039	0.022	0.0300	0.014	0	0.027	0.009	0.014	0.0064	0.29	0.00030	0.025	7.6e-03
2	GTEx	Adipose Subcutaneous	0.095	0.041	0.0034	0.043	NA	0.037	NA	0.049	0.0002	NA	0.00053	NA	7.3e-05
3	GTEx	Testis	0.236	0.084	0.0013	0.008	NA	0.016	NA	0.027	0.1300	NA	0.06200	NA	2.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.4	2.2	2.9	-0.9	1.7	1.7
Bipolar Disorder or Schizophrenia	0.3	0.7	1.1	-1.0	1.1	0.2
Depressed Affect (Nagel 2018)	0.7	1.5	2.5	-0.0	-1.4	1.6
Depression (Nagel 2018)	1.3	1.9	2.6	-0.8	-1.5	1.6
Intelligence (Savage-Jansen 2018)	1.4	4.3	6.2	-2.4	0.9	-2.5
Neuroticism (Nagel 2018)	0.9	2.2	3.6	1.4	-1.1	1.9
Schizophrenia (2018)	0.3	0.6	1.4	-0.6	-0.0	-1.2
Schizophrenia vs Biploar Disorder	1.9	2.5	7.1	0.2	-0.4	-2.7
Worry (Nagel 2018)	1.5	3.1	8.0	2.8	-0.5	1.0
Alzheimer’s Disease (in mother)	1.6	1.8	3.2	1.8	0.3	-1.5
Alzheimer’s Disease (in father)	0.5	0.5	0.8	-0.1	-0.9	0.9
Alzheimer’s Disease (including proxy)	0.5	0.8	1.7	1.3	0.0	-0.8
Crohns Disease (2017)	0.6	1.3	2.7	1.1	0.2	-1.6
Irritable Bowel Disease (IBD)	0.9	2.1	5.0	-0.2	1.1	-2.2
Ulcerative Colitis (UC)	0.9	1.8	3.5	-1.1	0.9	-1.9
Major Depression (MDD)	0.6	0.8	1.3	0.6	-0.8	1.1
Reaction Time	0.5	1.0	2.2	-0.2	-0.8	1.5
Verbal and Numeric Reasoning (VNR)	2.1	5.0	9.5	-3.1	1.5	-1.8
Breast Cancer	1.1	2.6	7.2	-2.7	-0.3	0.6
Ovarian Cancer	0.1	0.1	0.3	-0.2	-0.1	0.5
Prostate Cancer	13.6	19.1	32.1	-1.8	4.7	-5.7
Age at First Birth	0.2	0.4	0.8	0.9	0.2	0.4
Bipolar Disorder (2011)	1.1	1.1	3.2	-1.8	0.2	-0.2
Body Mass Index (BMI) (2010)	0.5	0.7	1.2	0.7	0.6	-1.1
Coronary Artery Disease (CAD)	0.4	0.5	1.0	1.0	-0.2	-0.7
Crohns Disease (2012)	1.6	2.6	4.4	2.1	1.6	-0.9
Mean Putamen Volume	0.5	0.5	1.3	0.4	0.4	-1.1
Fasting Glucose	1.1	1.3	3.0	-1.7	-0.7	0.7
HbA1C	0.7	0.8	1.5	-1.2	-0.9	0.2
HDL Cholesterol	0.2	0.3	0.5	-0.5	0.7	0.2
LDL Cholesterol	0.7	1.1	2.0	-0.7	-0.9	-1.4
Lupus	1.5	2.3	3.6	-0.4	-1.8	1.9
Neuroticism (2016)	1.8	2.6	4.4	1.1	-1.5	2.1
Primary Biliary Cirrhosis	0.7	1.0	2.4	-0.7	1.5	-0.3
Rheumatoid Arthritis	0.4	0.5	1.0	1.0	0.8	0.2
Schizophrenia (2014)	0.7	1.5	3.4	-1.8	0.3	-1.1
Triglycerides	0.4	0.6	1.5	0.6	-1.2	-0.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.1	-1.0	-1.0	0.4
Ulcerative Colitis	1.2	1.7	2.1	-1.0	1.4	-1.4
Blood Eosinophil Count	0.1	0.9	1.3	0.5	1.1	-1.0
Blood Platelet Count	0.9	10.9	25.7	0.3	2.6	-5.1
Blood Red Count	0.2	1.7	2.8	-1.7	-0.0	1.5
Blood White Count	0.1	0.6	1.5	-0.0	0.4	1.2
Heel T-Score	0.2	1.3	3.0	0.3	-1.7	0.9
BMI	0.2	1.4	3.5	-1.9	-0.3	-0.8
Height	0.6	10.7	15.8	2.2	4.0	-3.4
Waist Hip Ratio (WHR)	2.0	9.0	14.4	1.1	-3.4	3.8
Systolic Blood Pressure	0.1	0.6	1.1	-0.3	-0.7	1.0
Smoking Status	0.4	1.0	1.2	1.1	-0.9	1.0
Allergy or Eczema	0.5	1.2	2.5	1.6	-0.8	0.6
Cardiovascular Disease	1.5	4.9	9.2	-0.9	-3.0	2.2
Hypothyroidism (self reported)	0.4	0.9	1.6	-0.6	-1.3	-0.9
Respiratory disease	0.3	0.7	1.0	0.9	1.0	0.6
Type 2 Diabetes (T2D) (2018)	1.9	3.6	8.8	-1.2	-3.0	0.6
Lung FEV1/FVC ratio	1.3	6.5	15.8	-0.8	-4.0	1.8
Lung FVC	1.0	5.3	8.4	2.9	-2.7	0.1
Neuroticism	0.5	1.2	2.7	1.7	-0.0	1.0
Chronotype (morning person)	0.4	0.9	1.4	-1.2	-0.5	-0.9
Hair Pigment	0.1	1.8	3.6	1.1	-0.8	-1.9
Tanning	0.0	0.6	1.3	-1.1	0.3	-0.6
Hand grip strength (left)	0.6	1.7	4.7	-0.3	0.5	-2.2
Number of treatments/medications taken	1.0	1.8	4.4	-0.3	-1.0	2.1
Average weekly spirits intake	0.8	0.9	1.8	-1.4	0.8	-0.6
Sensitivity / hurt feelings	0.1	0.2	0.6	0.2	0.0	0.7
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.8	-0.9	-1.7	0.9
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.1	-0.0	-0.5
Relative age of first facial hair	0.4	0.8	1.8	-1.4	0.4	0.7
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	7.5	-0.7	-2.7	0.3
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.3	0.7	-0.7	1.5
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.1	0.2	0.4
Systolic blood pressure, automated reading	0.0	0.1	0.3	-0.1	-0.1	-0.6
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	4.1	-2.0	0.9	1.3
Angina	2.4	3.2	4.9	-2.2	-2.2	0.3
Medication for hormone replacement therapy	0.2	0.2	0.6	0.3	0.8	0.1
Vitamin and mineral supplements	0.8	1.1	3.0	1.7	0.6	0.2
Supplements: Zinc	0.4	0.4	0.6	0.3	-0.7	-0.8
Medication: Co-codamol	1.0	1.2	3.2	0.6	1.8	-0.1
Medication: Metformin	2.5	3.5	10.2	-0.4	-3.2	-0.3
Diabetes (father)	0.8	0.9	2.8	-1.7	-0.1	-0.1
Diabetes (mother)	2.7	3.5	5.5	-2.2	-2.4	0.2
Severe depression (siblings)	0.7	0.7	1.8	-1.3	-0.5	0.4
Pack years adult smoking proportion	0.6	0.9	1.5	-0.1	1.2	-1.1
Impedance of leg (right)	0.4	2.1	2.4	1.4	-1.4	1.6
Leg fat-free mass (left)	0.8	4.1	7.7	-1.3	1.7	-2.8
Trunk fat percentage	0.6	2.2	4.7	-2.2	-1.2	0.8
Hand grip strength (right)	0.4	1.2	2.5	-1.0	-0.3	-1.6
Townsend deprivation index at recruitment	1.6	2.2	5.5	0.1	-1.1	-2.3
Current tobacco smoking	0.2	0.4	0.9	0.3	-0.3	-1.0
Average weekly fortified wine intake	0.6	0.7	1.8	0.5	0.2	-1.4
Maternal smoking around birth	0.2	0.3	0.5	-0.7	-0.3	0.5
Fed-up feelings	1.6	2.9	4.9	0.4	-1.9	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	1.8	-1.4	-1.4	0.2
Relative age voice broke	0.1	0.2	0.3	0.3	-0.5	-0.5
Taking other prescription medications	0.2	0.4	0.7	0.5	-0.3	0.9
Age when periods started (menarche)	0.3	0.8	1.3	-1.1	0.1	1.0
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.3	1.5	-1.4	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	0.7	-0.8	-0.8	0.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.5	-1.1	1.1	-1.2
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.3	0.5	-0.8
Serious illness, injury or assault to yourself	0.6	0.7	1.5	-1.2	-0.2	0.8
High blood pressure	1.3	3.7	5.5	-0.4	-2.3	2.3
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.7	1.9	-0.5	0.7
Multivitamins +/- minerals	1.0	1.3	1.9	-1.3	-1.4	0.6
Stomach or abdominal pain in last month	0.9	1.1	2.7	0.6	-1.6	-0.5
Supplements: Glucosamine	1.8	2.4	6.2	-0.6	0.7	2.5
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.1	-0.2	-0.3
Medication: Atenolol	2.9	3.6	8.2	-1.6	-2.9	0.3
Medication: Levothyroxine sodium	0.5	0.9	2.1	0.0	-1.5	0.7
Sitting height	1.1	7.8	14.9	1.4	2.6	-3.9
Chronic bronchitis/emphysema (father)	0.9	1.0	2.5	1.6	0.7	-0.4
High blood pressure (mother)	0.2	0.3	0.7	-0.4	-0.8	-0.2
Body mass index (BMI)	0.5	2.0	4.1	-2.0	-1.3	-0.4
Impedance of leg (left)	0.6	3.0	4.6	2.1	-1.2	1.7
Leg predicted mass (left)	0.8	4.3	8.0	-1.3	1.8	-2.8
Trunk fat mass	0.3	1.5	4.0	-2.0	-0.6	-0.3
Waist circumference	0.4	1.3	2.8	-1.0	-1.7	0.5
Number of incorrect matches in round	1.7	2.8	5.4	1.5	-0.7	2.3
Past tobacco smoking	0.7	1.3	3.1	-0.5	1.8	-0.8
Alcohol usually taken with meals	0.8	1.2	1.8	1.3	-0.5	1.4
Nervous feelings	1.5	2.8	5.0	2.2	-0.9	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.5	-0.1	-0.6	1.2
Hearing difficulty/problems with background noise	0.2	0.2	0.5	-0.0	-0.5	-0.7
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.3	-0.9	-0.1
Had menopause	0.9	1.1	2.2	1.5	0.4	1.0
Had other major operations	0.5	0.7	1.1	0.4	0.9	-1.1
Forced vital capacity (FVC)	0.8	3.2	7.0	2.6	-0.5	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.2	-0.9	-1.1	0.6
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	-0.4	0.4	0.3
Qualifications: None of the above	0.5	1.0	1.6	1.3	0.5	1.0
Financial difficulties in last 2 years	1.1	1.5	3.9	-0.8	0.3	-2.0
Mouth/teeth dental problems	0.2	0.4	1.1	0.2	1.0	0.1
Heart attack	0.5	0.6	0.9	-1.0	-0.9	0.3
Allergy	1.2	2.7	5.0	-2.2	0.4	-1.7
Pain all over the body in last month	0.1	0.2	0.2	0.3	-0.4	0.4
Diabetes (self-reported)	2.4	3.8	10.3	-0.5	-3.2	0.8
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.4	0.6	0.4	-0.1
Medication: Ramipril	1.5	1.9	3.6	-1.1	-1.9	1.0
Medication: Simvastatin	1.3	1.8	4.4	-1.0	-2.1	0.3
Fluid intelligence score	2.4	5.0	11.5	-3.4	0.9	-1.6
Illnesses of siblings	1.6	2.2	2.7	-1.2	1.6	-1.6
Neuroticism score	0.3	0.7	1.1	1.0	-0.3	0.9
Weight	0.3	1.5	2.8	-1.3	0.2	-1.7
Impedance of arm (right)	0.5	2.1	6.2	-0.1	-0.3	2.5
Arm fat percentage (right)	0.9	3.7	8.5	-2.9	-1.6	0.5
Trunk fat-free mass	1.0	6.0	13.7	0.1	2.1	-3.7
Hip circumference	0.4	1.8	3.1	-1.5	0.4	-1.8
Time employed in main current job	2.1	2.4	5.9	-0.1	-1.1	2.4
Alcohol intake versus 10 years previously	0.5	0.8	1.2	1.1	0.2	-1.0
Father’s age at death	0.2	0.2	0.7	0.8	-0.2	0.0
Worrier / anxious feelings	1.8	3.3	7.5	2.7	-1.6	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	1.7	-1.3	-1.1	0.9
Falls in the last year	0.9	1.2	2.3	0.3	-1.1	-1.5
Hair/balding pattern: Pattern 3	0.8	1.2	1.7	1.3	-1.2	0.6
Number of live births	0.9	1.3	3.5	0.1	-0.7	1.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	2.5	1.3	-1.6	-0.7
Pulse rate	0.6	0.9	2.2	-1.5	0.6	0.5
Happiness	0.7	0.9	1.8	-0.4	-0.8	-1.3
Noisy workplace	0.5	0.6	1.1	-0.7	1.1	-0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.7	-1.3	-0.6	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.0	-1.0	0.1	0.9
Mouth/teeth dental problems: Dentures	0.2	0.4	0.5	0.5	0.6	-0.7
Asthma	0.3	0.5	0.9	0.7	-0.2	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.5	1.2	0.1	0.3
Medication: Cholesterol lowering	1.6	2.5	3.3	-1.3	-1.8	1.6
Depression (self-reported)	0.1	0.1	0.3	-0.1	-0.5	0.2
Medication: Lansoprazole	0.3	0.4	0.8	0.9	-0.4	0.4
Prospective memory result	0.5	0.6	1.0	0.2	-0.9	1.0
Lung cancer (father)	1.0	1.2	2.0	0.1	1.3	-1.4
Illnesses of mother	0.3	0.4	1.1	-0.4	1.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.0	1.1	-2.0	-0.3
Pulse wave Arterial Stiffness index	1.4	1.6	2.4	-1.5	-0.6	1.5
Impedance of arm (left)	0.4	1.7	4.8	-0.6	-0.1	2.2
Arm fat mass (right)	0.6	2.5	5.7	-2.4	-1.2	-0.6
Trunk predicted mass	1.1	6.0	13.6	0.1	2.1	-3.7
Standing height	0.6	6.3	9.4	1.6	3.1	-2.6
Length of working week for main job	0.8	0.9	1.4	0.1	-1.1	1.2
Exposure to tobacco smoke at home	0.3	0.3	0.3	0.5	0.6	-0.6
Breastfed as a baby	0.3	0.4	0.5	0.7	0.6	0.4
Tense / ‘highly strung’	1.9	3.2	6.5	2.5	-0.7	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	5.0	0.6	-1.4	2.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	-0.6	0.3	-0.7
Birth weight of first child	0.3	0.5	1.5	1.2	0.2	0.0
Peak expiratory flow (PEF)	0.4	0.9	1.6	-0.8	-1.3	0.7
Pulse wave reflection index	1.7	2.1	6.2	-0.2	-2.5	0.1
Ever highly irritable/argumentative for 2 days	2.6	3.2	7.4	-2.7	-1.3	0.7
Loud music exposure frequency	1.5	1.6	4.0	-2.0	-0.9	-0.2
Qualifications: O levels/GCSEs or equivalent	1.5	2.5	4.8	-2.2	1.5	0.6
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	6.6	-0.6	-2.6	0.6
Blood clot in the leg (DVT)	1.9	2.4	6.2	0.1	-2.5	-1.0
Medication: Paracetamol	0.5	0.8	1.0	-0.7	-1.0	1.0
Headache pain in last month	0.2	0.4	0.7	0.2	-0.5	0.9
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	4.9	2.2	1.3	-1.4
Glaucoma (self-reported)	0.6	0.7	1.8	-0.3	-1.3	-0.4
Gout (self-reported)	0.2	0.2	0.5	0.7	0.4	0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	3.1	-0.3	-1.8	-0.1
Medication: Amlodipine	0.7	0.9	1.4	-0.2	1.1	1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.6	0.4	1.2	0.1
Birth weight	3.1	6.7	11.8	2.6	3.4	-1.3
Chronic bronchitis/emphysema (mother)	2.0	2.4	3.4	1.8	1.3	1.4
High blood pressure (siblings)	1.4	2.1	2.9	1.7	-1.0	1.5
Forced vital capacity (FVC), Best measure	0.4	1.6	3.3	1.8	-1.0	-0.6
Body fat percentage	0.6	2.3	4.6	-2.1	-1.4	0.6
Leg fat percentage (right)	0.7	2.6	5.2	-1.6	-2.3	0.4
Arm fat-free mass (right)	0.9	4.9	11.8	0.2	1.7	-3.4
Exposure to tobacco smoke outside home	1.0	1.3	3.1	-1.8	-1.0	-0.0
Comparative body size at age 10	0.3	0.9	1.5	-1.1	-0.2	-1.2
Number of full brothers	0.2	0.2	0.5	-0.7	-0.2	-0.3
Worry too long after embarrassment	0.1	0.1	0.2	0.4	-0.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	4.0	0.5	-0.6	2.0
Wheeze or whistling in the chest in last year	0.2	0.4	1.1	-0.4	1.1	-0.2
Number of children fathered	1.3	1.5	3.2	-1.1	-0.3	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.6	0.6	-1.2	0.7
Age at first live birth	0.7	1.3	2.7	0.8	-0.8	1.6
Pulse wave peak to peak time	1.8	2.1	2.8	1.7	0.9	-1.6
Health satisfaction	1.5	1.9	5.0	-2.2	0.5	-0.8
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.5	-0.4	0.6
Qualifications: College or University degree	0.6	1.8	2.6	0.5	1.6	-1.6
Eye problems/disorders: None of the above	1.4	1.6	3.7	1.9	0.1	1.0
Mouth/teeth dental problems: Loose teeth	1.5	1.7	4.1	0.0	-2.0	1.1
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.4	0.4	0.1
Medication for pain relief, constipation, heartburn	1.7	3.0	5.5	0.7	1.7	-2.3
Neck or shoulder pain in last month	0.6	0.9	2.1	-1.5	-0.3	-0.7
Medication: Blood pressure	1.1	1.9	3.2	-1.8	-1.0	1.2
Angina (self-reported)	2.9	3.8	5.8	-2.4	-2.4	0.2
Migraine (self-reported)	0.3	0.4	0.7	-0.7	0.8	-0.3
Medication: Ibuprofen	0.3	0.3	0.4	0.5	0.5	0.6
Medication: Allopurinol	0.2	0.3	0.4	0.5	0.6	-0.4
Medication: Omeprazole	0.7	0.9	1.6	-0.5	-1.3	0.9
Medication: Seretide 50 evohaler	1.9	2.2	6.0	2.4	-0.6	0.4
Mean time to correctly identify matches	0.9	1.7	4.0	-0.0	-1.1	2.0
Heart disease (mother)	0.4	0.5	0.9	0.8	-0.9	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	-1.2	0.1	-0.8
Whole body fat mass	0.5	2.1	5.5	-2.4	-0.5	-0.7
Leg fat mass (right)	0.5	1.9	3.7	-1.9	-1.2	-0.7
Arm predicted mass (right)	1.1	5.4	14.2	0.4	1.4	-3.8
Pulse rate, automated reading	0.2	0.8	1.6	-1.3	0.5	0.6
Alcohol intake frequency.	0.1	0.3	0.6	0.1	-0.8	-0.6
Comparative height size at age 10	0.8	4.4	7.8	1.4	1.9	-2.8
Number of full sisters	1.1	1.4	2.8	-1.7	0.3	-1.1
Suffer from ‘nerves’	0.9	1.4	4.0	2.0	0.2	-0.2
Overall health rating	0.4	0.8	1.2	0.3	-1.1	1.1
Chest pain or discomfort	1.1	1.6	3.9	-2.0	-1.0	0.1
Had major operations	0.6	0.8	1.6	0.2	-0.8	1.3
Age at last live birth	0.9	1.3	2.4	1.6	-0.0	1.2
Family relationship satisfaction	0.8	1.0	2.4	-0.6	0.4	-1.6
Leg pain on walking	1.8	2.3	3.8	-1.4	1.0	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	1.5	-0.5	-1.2	0.5
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.5	0.5	-1.2	1.9
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	3.4	1.9	0.6	1.7
Medication: Aspirin	1.7	2.2	3.8	-0.5	-1.6	2.0
Supplements: Vitamin C	0.4	0.5	1.1	-1.0	0.6	0.3
Knee pain experienced in last month	0.3	0.4	1.2	-0.1	-1.1	0.1
Hypertension (Self-reported)	1.1	3.0	5.8	-0.5	-2.4	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	6.1	-0.7	-2.5	1.4
Illnesses of father: Heart disease	1.3	1.8	3.6	-0.9	1.0	1.9
Illnesses of siblings: Diabetes	1.6	2.0	3.2	-1.1	-1.8	1.2
Smoking status: Previous	0.3	0.5	0.9	0.3	-0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.2	-0.4	0.5	-1.8
Whole body fat-free mass	1.0	5.4	12.1	-0.3	2.0	-3.5
Leg fat-free mass (right)	0.9	4.6	8.8	-0.9	2.1	-3.0
Arm fat percentage (left)	1.0	4.0	10.3	-3.2	-1.3	0.2
Average weekly red wine intake	0.7	1.0	2.8	-0.4	0.1	1.7
Handedness (chirality/laterality): Left-handed	0.9	1.0	1.7	0.9	-0.7	1.3
Mood swings	1.5	2.8	4.0	-1.5	-1.4	2.0
Loneliness, isolation	1.6	2.2	6.3	-0.2	-2.5	-0.5
Long-standing illness, disability or infirmity	0.2	0.2	0.6	-0.3	-0.8	-0.1
Ever had bowel cancer screening	2.5	3.0	5.8	-0.7	-1.6	2.4
Diabetes diagnosed by doctor	2.7	4.4	11.6	-1.0	-3.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	0.2	0.1	-0.2
Friendships satisfaction	0.5	0.6	1.6	0.4	0.2	-1.3
Qualifications: nursing, teaching	0.2	0.3	0.8	-0.2	0.1	-0.9
Commuting to job workplace: Walk	0.7	0.8	1.4	-0.8	-1.2	0.4
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.1	-0.5	0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.0	-1.4	-0.4	-0.1
Medication for cholesterol	0.5	0.8	1.3	-0.3	1.1	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.2	-0.4	-0.1
Back pain experienced in last month	0.0	0.0	0.1	0.3	0.0	0.1
Mineral and other dietary supplements	1.0	1.3	2.0	1.4	-1.4	0.4
Breast cancer (self-reported)	0.1	0.1	0.2	0.2	-0.4	0.2
Asthma (self-reported)	0.3	0.6	1.1	0.7	0.1	1.1
Osteoporosis (self-reported)	0.8	1.0	1.4	0.4	1.2	1.2
Osteoarthritis (self-reported)	3.6	4.7	7.4	1.6	-2.0	2.7
Medication: Aspirin	1.9	2.5	3.5	-0.9	-1.8	1.9
Medication: Gliclazide	1.1	1.3	2.6	0.9	-1.6	-0.7
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	-0.1	-0.5	-0.5
Smoking status: Current	0.4	0.6	0.7	0.7	-0.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.4	5.0	11.6	1.7	-3.4	0.7
Whole body water mass	1.0	5.5	12.4	-0.3	2.0	-3.5
Leg predicted mass (right)	0.8	4.4	8.4	-0.8	2.0	-2.9
Arm fat mass (left)	0.7	2.7	6.7	-2.6	-1.0	-0.7
Number of self-reported non-cancer illnesses	1.4	2.5	4.6	-0.1	-2.1	1.7
Average weekly champagne plus white wine intake	0.0	0.1	0.1	-0.2	-0.3	-0.2
Miserableness	1.2	2.1	3.7	-0.8	-1.4	1.9
Guilty feelings	0.2	0.2	0.3	0.6	0.3	0.5
Wears glasses or contact lenses	4.0	4.6	10.9	0.4	-1.7	3.3
Ever taken oral contraceptive pill	0.4	0.4	1.0	-0.6	0.1	-1.0
Hearing aid user	0.1	0.1	0.4	-0.0	0.2	-0.6
Mother’s age at death	2.1	2.6	4.9	2.2	-0.6	1.6
Financial situation satisfaction	2.5	3.1	6.7	-0.5	-2.6	-1.5
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.2	-1.5	0.9	-0.7
Commuting to job workplace: Public transport	0.3	0.4	0.6	-0.6	0.8	-0.5
Eye problems/disorders: Glaucoma	0.8	1.0	2.0	-0.9	-0.2	-1.4
Medication: Blood pressure	1.0	1.9	3.9	0.5	-2.0	1.3
Pain type(s) experienced in last month: Hip pain	1.7	2.1	5.5	-0.0	-2.4	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.1	-0.5	0.4	-1.1
High cholesterol (Self-reported)	1.1	1.9	3.5	-0.9	-1.9	1.1
Medication: Bendroflumethiazide	0.7	1.1	2.1	1.1	0.0	1.4
Medication: Paracetamol	1.2	1.9	2.9	-0.6	-1.7	1.5
Medication: Lisinopril	1.7	2.2	5.4	-2.3	-0.0	-1.0
Medication: Atorvastatin	0.8	1.0	1.6	-0.1	-1.3	1.1
Illnesses of father: High blood pressure	0.4	0.4	0.8	-0.6	0.4	0.9
Alcohol drinker status: Never	1.1	1.4	3.3	0.8	0.4	-1.8
Ever smoked	0.3	0.6	1.5	0.5	-1.2	-0.2
Basal metabolic rate	0.8	4.2	9.7	-0.7	1.5	-3.1
Leg fat percentage (left)	0.5	1.9	4.1	-1.2	-2.0	0.5
Arm fat-free mass (left)	0.8	4.1	10.9	0.6	1.0	-3.3
Number of operations (self-reported)	0.6	0.9	2.2	-0.2	-1.5	0.6
Average weekly beer plus cider intake	0.2	0.3	0.9	0.3	-0.9	0.1
Irritability	0.9	1.5	4.2	-0.1	-2.1	0.5
Risk taking	1.0	1.4	4.0	0.4	-2.0	0.2
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.6	0.5	0.2	1.6
Fractured/broken bones in last 5 years	1.9	2.4	4.3	2.1	1.1	-1.3
Age started oral contraceptive pill	1.2	1.5	4.6	2.1	0.1	0.1
Diastolic blood pressure, automated reading	0.1	0.2	0.4	0.1	0.6	-0.5
Ever depressed for a whole week	1.8	2.3	4.4	1.4	-2.1	0.6
Unable to work because of sickness or disability	1.2	1.6	3.3	0.3	-1.8	1.2
Commuting to job workplace: Cycle	2.0	2.4	2.9	-1.7	1.3	-1.6
Myopia	0.2	0.3	0.5	0.5	0.7	0.4
Vascular/heart problems diagnosed by doctor	1.0	2.8	4.7	0.6	2.2	-1.9
Cholesterol lowering medication	1.6	2.4	6.3	0.7	-2.5	0.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	2.2	-1.2	-1.5	1.4
Pain experienced in last month	0.3	0.5	1.4	0.2	1.2	0.4
Supplements: Calcium	0.2	0.2	0.4	-0.6	-0.4	0.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.0	0.9	1.0	0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.0	-0.9	-1.0	0.4
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	6.0	0.1	-2.5	-1.1
Heart disease (siblings)	1.4	1.8	2.9	-0.1	-1.7	1.5
Alcohol drinker status: Previous	1.0	1.2	2.7	-0.7	-0.6	1.6
Pack years of smoking	0.4	0.5	1.2	-0.4	1.1	-0.5
Impedance of whole body	0.4	2.1	5.1	1.0	-0.5	2.3
Leg fat mass (left)	0.4	1.4	2.8	-1.7	-1.1	-0.6
Arm predicted mass (left)	0.7	3.8	9.8	0.5	1.1	-3.1