TWAS hub - EEFSEC

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0260	1.0e-05	0.036	0.040	0.029	0.039	0.034	3.3e-05	1.2e-05	1.6e-04	1.3e-05	5.3e-05
2	GTEx	Adipose Subcutaneous	0.0650	0.0270	1.2e-03	0.029	NA	0.055	NA	0.050	1.8e-03	NA	2.4e-05	NA	5.8e-05
3	GTEx	Breast Mammary Tissue (Female)	0.0443	0.0471	2.0e-01	-0.009	NA	-0.009	NA	-0.009	7.8e-01	NA	8.4e-01	NA	7.9e-01
4	GTEx	Cells Transformed fibroblasts	0.0770	0.0330	1.5e-03	0.083	NA	0.038	NA	0.061	8.5e-07	NA	6.8e-04	NA	2.4e-05
5	GTEx	Esophagus Muscularis	0.0740	0.0300	1.2e-03	0.080	NA	0.055	NA	0.070	1.4e-05	NA	2.8e-04	NA	4.5e-05
6	GTEx	Lung	0.1129	0.0425	1.0e-04	0.019	NA	0.060	NA	0.038	1.3e-02	NA	2.3e-05	NA	6.3e-04
7	GTEx	Muscle Skeletal	0.0500	0.0199	1.3e-03	0.012	NA	0.020	NA	0.020	2.1e-02	NA	4.3e-03	NA	4.3e-03
8	GTEx	Nerve Tibial	0.0739	0.0281	2.0e-04	0.058	NA	0.049	NA	0.060	6.5e-05	NA	2.1e-04	NA	4.5e-05
9	GTEx	Testis	0.4330	0.1020	2.5e-06	0.072	NA	0.170	NA	0.104	4.3e-04	NA	5.4e-08	NA	2.3e-05
10	TCGA	Bladder Urothelial Carcinoma	0.0360	0.0210	5.0e-03	0.018	0.021	0.007	NA	0.016	9.9e-03	6.7e-03	7.1e-02	NA	1.5e-02
11	TCGA	Glioblastoma Multiforme	0.0900	0.0510	7.7e-03	0.075	0.038	0.027	NA	0.045	2.8e-03	2.7e-02	5.1e-02	NA	1.7e-02
12	TCGA	Brain Lower Grade Glioma	0.0718	0.0309	2.2e-09	0.051	0.071	0.060	NA	0.063	2.0e-06	1.6e-08	2.4e-07	NA	1.0e-07
13	TCGA	Thyroid Carcinoma	0.0840	0.0620	6.0e-05	0.035	0.036	0.024	NA	0.035	2.4e-04	1.8e-04	2.1e-03	NA	2.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Prostate Cancer	27.8	39.1	60.2	-6.7	-6.7	1.1	-7.7	-7.8	-4.6	-6.7	-7.7	-2.6	-5.1	-6.4	-7.3	-6.8
Lung FEV1/FVC ratio	27.5	139.7	237.2	-12.6	-13.9	-3.7	-12.6	-12.9	-7.9	-8.6	-12.9	-3.3	-12.7	-14.3	-14.5	-15.4
Respiratory disease	10.8	24.1	38.7	5.0	5.1	1.9	5.3	5.5	4.3	3.8	5.4	2.9	5.1	5.8	5.6	6.2
Asthma (self-reported)	9.9	19.6	32.9	4.5	4.9	2.5	4.8	4.8	3.5	3.2	4.8	1.6	4.8	5.3	5.1	5.7
Asthma	9.1	18.0	30.1	4.5	4.7	2.7	4.5	4.6	3.3	3.0	4.6	1.2	4.6	5.1	4.9	5.5
Age when periods started (menarche)	7.7	18.5	31.7	-4.2	-4.6	-0.6	-5.6	-5.5	-3.0	-5.2	-5.6	-3.4	-2.2	-3.4	-5.0	-4.3
Ever had prostate specific antigen (PSA) test	6.1	7.0	13.8	-2.4	-2.4	-0.1	-3.7	-3.5	-2.2	-3.5	-3.6	-2.2	-1.0	-1.8	-3.0	-2.5
Number of full brothers	6.0	7.5	15.0	3.9	3.7	0.7	2.5	2.8	1.6	1.8	2.7	0.9	2.6	3.1	3.3	3.6
Number of self-reported non-cancer illnesses	5.8	10.1	17.8	3.7	3.8	3.0	2.9	2.7	2.1	0.9	2.7	0.2	3.9	4.2	3.9	4.2
Ever had hysterectomy (womb removed)	5.7	6.5	9.9	-2.9	-2.7	-1.0	-2.7	-2.9	-3.1	-3.1	-2.9	-3.0	-0.7	-1.5	-3.0	-1.9
Allergy	5.6	12.9	20.2	-3.5	-3.4	-2.9	-4.1	-4.2	-3.4	-3.3	-4.2	-1.5	-2.8	-3.8	-4.1	-4.5
Wheeze or whistling in the chest in last year	5.4	9.6	14.4	3.2	3.3	2.8	3.3	3.3	3.2	2.1	3.2	0.7	3.0	3.4	3.8	3.6
High blood pressure	5.1	14.2	27.4	5.2	4.3	-1.0	3.7	3.6	1.3	1.8	3.6	0.3	5.0	5.0	4.7	4.6
Hypertension (Self-reported)	4.8	13.4	24.6	5.0	4.2	-0.8	3.8	3.7	1.1	2.1	3.7	0.5	4.6	4.7	4.6	4.4
High blood pressure (siblings)	4.7	6.8	12.7	3.1	3.2	0.4	2.7	2.8	0.7	2.0	2.8	1.5	2.5	3.0	3.6	3.3
Had other major operations	4.6	5.7	9.1	2.8	3.0	-0.1	2.4	2.7	2.0	2.0	2.6	1.2	2.5	2.7	2.6	2.6
Vascular/heart problems diagnosed by doctor	4.2	11.4	22.9	-4.8	-4.0	0.6	-3.3	-3.1	-0.9	-1.5	-3.2	-0.3	-4.4	-4.5	-4.3	-4.1
Illnesses of father: None of the above (group 1)	4.1	5.0	10.1	-2.4	-2.9	-0.1	-2.0	-2.2	0.5	-1.3	-2.1	0.3	-3.2	-2.8	-3.2	-2.8
Medication: Ventolin 100micrograms inhaler	4.0	5.1	8.8	2.5	2.1	0.2	2.5	2.4	2.6	1.4	2.4	0.7	2.6	3.0	2.3	2.9
Average weekly beer plus cider intake	4.0	5.8	7.2	2.6	2.7	1.7	2.7	2.6	1.9	1.9	2.6	1.7	2.6	2.6	2.7	2.6
Bipolar Disorder or Schizophrenia	3.9	9.6	17.9	3.1	4.2	1.4	3.8	3.9	1.7	4.0	3.9	2.3	0.4	1.6	3.7	3.1
Schizophrenia (2018)	3.8	7.9	13.7	2.6	3.7	1.7	3.3	3.4	2.6	3.6	3.4	2.3	0.3	1.4	3.2	2.7
Cardiovascular Disease	3.6	11.8	20.7	4.5	4.5	1.2	3.5	3.5	2.3	2.4	3.5	1.2	3.3	3.7	4.4	4.2
Impedance of arm (left)	3.6	16.5	30.9	-5.6	-5.2	-1.6	-4.5	-4.3	-2.5	-3.1	-4.4	-1.0	-3.9	-4.5	-4.8	-4.5
Medication: Blood pressure	3.5	6.7	16.1	4.0	2.8	-0.6	2.4	2.1	0.7	0.8	2.1	0.1	3.5	3.7	3.4	3.1
Medication: Bendroflumethiazide	3.5	5.3	11.0	3.3	2.5	-0.0	2.1	2.0	1.9	0.6	2.0	0.8	3.0	3.3	2.9	2.6
Chronic bronchitis/emphysema (father)	3.4	3.9	6.7	2.6	2.3	1.2	1.7	1.8	1.6	0.9	1.8	-0.7	2.4	2.3	2.6	2.5
Impedance of arm (right)	3.4	15.7	27.4	-5.2	-5.1	-1.8	-4.4	-4.3	-2.3	-3.3	-4.4	-1.4	-3.7	-4.2	-4.7	-4.3
Mouth/teeth dental problems: Bleeding gums	3.4	4.4	11.2	-1.4	-1.9	1.4	-2.8	-2.7	-1.6	-3.3	-2.8	-2.5	0.3	-0.5	-2.1	-1.5
Osteoporosis (self-reported)	3.4	4.2	7.3	-2.1	-2.7	-1.2	-2.5	-2.4	-1.5	-2.3	-2.5	-1.2	-0.9	-1.5	-2.5	-2.2
Illnesses of siblings	3.2	4.4	8.5	-2.9	-2.7	0.5	-2.0	-2.1	0.2	-0.9	-2.1	-0.3	-2.4	-2.7	-2.6	-2.8
Schizophrenia (2014)	3.1	7.0	12.2	2.6	3.5	0.9	3.4	3.4	1.2	3.3	3.4	1.3	0.8	1.7	3.3	2.8
Blood Platelet Count	3.0	34.9	60.1	6.2	6.3	1.2	6.4	6.6	4.5	4.4	6.5	1.7	6.0	7.2	7.5	7.8
Father’s age at death	3.0	4.0	8.4	2.9	2.2	-0.3	1.9	2.2	1.4	1.6	2.2	0.2	1.6	2.2	2.4	2.7
Number of treatments/medications taken	2.9	5.3	10.2	3.1	3.2	-0.2	2.5	2.3	1.1	1.4	2.3	0.4	2.1	2.5	3.1	2.9
Relative age of first facial hair	2.9	6.0	9.4	-2.5	-2.4	0.7	-3.0	-3.1	-2.8	-3.0	-3.0	-1.9	-1.5	-2.0	-2.9	-1.9
Exposure to tobacco smoke at home	2.9	3.3	5.6	1.3	2.4	-1.1	2.0	2.3	1.1	2.2	2.2	0.2	1.1	1.7	2.3	2.1
Blood clot in the leg (DVT)	2.9	3.8	7.0	2.6	2.5	1.6	1.8	1.8	1.3	0.9	1.8	1.0	1.9	2.2	2.4	2.5
Impedance of whole body	2.9	14.7	27.1	-5.2	-5.1	-1.1	-4.1	-4.0	-2.9	-2.7	-4.0	-0.7	-3.9	-4.4	-4.6	-4.1
Body mass index (BMI)	2.8	12.0	23.9	4.9	4.6	1.2	3.2	3.3	2.7	1.9	3.2	0.2	3.9	4.2	4.2	4.0
Alcohol usually taken with meals	2.7	4.4	8.8	-1.5	-2.2	-3.0	-1.6	-1.8	-2.7	-0.9	-1.7	1.1	-2.5	-2.6	-2.3	-2.2
Forced expiratory volume in 1-second (FEV1)	2.7	9.1	22.3	-3.3	-3.7	1.6	-2.6	-2.5	0.5	-0.6	-2.5	1.2	-4.7	-4.4	-3.5	-4.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.7	8.6	23.1	-2.9	-3.8	1.0	-2.4	-2.2	0.3	-0.2	-2.3	1.2	-4.8	-4.4	-3.3	-4.2
Coronary Artery Disease (CAD)	2.6	3.1	6.7	-2.4	-2.1	1.2	-1.4	-1.2	-1.0	-0.4	-1.5	0.8	-2.4	-2.4	-2.6	-1.9
Rheumatoid Arthritis	2.6	3.6	7.7	-2.3	-2.8	-1.2	-1.7	-1.8	0.3	-1.5	-1.8	-2.3	-1.7	-1.9	-1.9	-2.3
Birth weight of first child	2.6	4.7	8.7	-1.9	-2.2	-1.0	-2.7	-2.9	-0.4	-3.0	-2.9	-1.1	-0.8	-1.6	-2.9	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.6	13.2	-1.7	-3.3	-0.6	-2.2	-2.2	-1.2	-1.1	-2.2	0.5	-3.1	-3.1	-3.0	-3.6
Deep venous thrombosis (DVT) (self-reported)	2.6	3.4	6.8	2.6	2.4	1.6	1.6	1.6	1.1	0.8	1.7	0.8	1.8	2.1	2.3	2.3
Medication: Co-codamol	2.5	2.9	5.5	2.3	2.0	0.1	1.6	1.4	1.4	0.4	1.5	-0.3	2.4	2.2	2.1	2.1
Qualifications: A levels/AS levels or equivalent	2.5	5.4	9.8	-1.6	-3.1	-0.9	-2.7	-2.7	-0.7	-2.3	-2.7	-1.4	-2.2	-2.4	-2.6	-3.1
Qualifications: O levels/GCSEs or equivalent	2.3	3.7	11.2	-1.7	-2.2	-1.0	-1.2	-1.5	0.6	-0.3	-1.5	-0.2	-3.3	-3.0	-2.1	-2.9
Systolic Blood Pressure	2.1	10.6	19.8	3.7	3.6	-0.0	3.5	3.2	2.0	1.7	3.3	0.2	3.8	4.3	4.5	4.1
Waist circumference	2.1	7.8	17.5	4.2	3.8	1.3	2.1	2.3	2.0	0.8	2.2	-0.9	3.7	3.6	3.3	3.1
BMI	2.0	11.3	24.5	5.0	4.6	2.0	2.6	2.8	3.0	1.2	2.7	0.2	4.0	4.0	4.1	4.0
Age at last live birth	2.0	2.9	5.4	-1.7	-1.9	0.2	-2.2	-2.2	-2.1	-2.3	-2.2	-0.5	-0.5	-1.0	-1.9	-1.2
Medication for cholesterol	2.0	3.0	5.8	-2.4	-2.0	0.7	-2.2	-1.9	-0.3	-1.3	-1.9	-0.6	-1.6	-2.0	-2.1	-1.8
Average weekly champagne plus white wine intake	2.0	2.7	5.5	-2.0	-1.4	-1.2	-1.4	-1.3	-2.4	-0.5	-1.3	0.9	-2.1	-2.3	-1.7	-2.0
Taking other prescription medications	1.9	2.9	5.0	2.1	2.0	1.4	2.0	1.7	0.6	0.8	1.8	0.3	1.6	1.9	2.2	2.2
High blood pressure (mother)	1.9	2.7	7.3	2.4	1.5	1.2	1.3	1.2	0.6	0.3	1.2	-0.3	2.7	2.4	1.8	2.1
Headache pain in last month	1.9	3.2	5.9	-1.8	-1.8	0.4	-2.3	-2.3	-0.9	-2.4	-2.3	-2.3	-0.5	-1.1	-1.9	-1.6
Worry too long after embarrassment	1.9	3.2	6.5	-1.1	-1.9	1.6	-2.3	-2.5	-0.3	-2.5	-2.4	-1.5	-0.9	-1.4	-2.0	-1.3
Medication: Omeprazole	1.9	2.2	4.7	2.2	2.0	-1.5	1.6	1.8	-0.3	1.5	1.7	0.9	0.4	0.9	1.5	1.7
Supplements: Vitamin C	1.9	2.2	4.2	-1.8	-1.6	1.8	-1.6	-1.7	-0.8	-1.6	-1.7	-0.4	-0.9	-1.4	-2.0	-1.4
Arm fat mass (left)	1.9	7.8	15.2	3.9	3.6	1.5	2.6	2.7	2.6	1.7	2.6	0.4	3.0	3.3	3.4	2.9
Leg fat mass (left)	1.9	7.5	16.2	4.0	3.8	1.4	2.6	2.7	1.9	1.7	2.6	0.4	2.9	3.1	3.3	2.9
Average weekly spirits intake	1.8	2.2	7.2	2.7	1.4	-0.0	0.6	0.6	-0.8	-0.5	0.6	-1.4	2.4	2.3	1.3	1.7
Hand grip strength (right)	1.8	4.8	12.7	2.3	1.4	0.4	2.5	2.6	2.6	3.5	2.6	3.6	-0.7	0.1	1.4	1.0
Medication: Atenolol	1.8	2.2	4.6	1.9	2.0	-0.3	0.7	0.8	1.6	-0.3	0.7	-1.1	2.0	2.0	1.8	2.1
Heart attack	1.8	2.4	7.3	1.9	2.7	1.7	1.3	1.2	-0.0	0.5	1.3	0.1	1.7	1.6	2.0	1.7
Arm fat mass (right)	1.8	7.4	14.1	3.8	3.6	1.4	2.6	2.7	2.5	1.7	2.6	0.3	2.8	3.2	3.3	2.8
Breastfed as a baby	1.8	2.2	4.3	-0.9	-2.1	0.7	-1.9	-1.8	-1.9	-1.6	-1.8	-0.9	-0.7	-1.0	-1.7	-1.3
Leg fat mass (right)	1.8	6.8	14.7	3.8	3.6	1.3	2.4	2.6	1.7	1.6	2.5	0.3	2.8	3.0	3.2	2.7
Long-standing illness, disability or infirmity	1.8	2.8	6.6	1.3	2.6	1.6	1.9	1.8	0.4	1.2	1.8	0.4	1.3	1.6	2.2	2.1
Heart attack/myocardial infarction (self-reported)	1.8	2.3	7.5	1.8	2.7	1.8	1.1	1.0	-0.3	0.2	1.1	-0.1	1.8	1.6	1.9	1.7
Hand grip strength (left)	1.7	4.5	11.6	2.2	1.8	0.0	2.6	2.7	2.4	3.4	2.7	2.4	-0.5	0.5	1.8	1.4
Impedance of leg (right)	1.7	8.0	15.0	-3.7	-3.9	-1.2	-2.8	-2.7	-3.5	-1.8	-2.7	-0.6	-2.8	-3.1	-3.3	-2.9
Arm fat-free mass (left)	1.7	8.7	14.0	3.7	3.4	3.1	3.1	3.2	3.4	2.9	3.2	1.8	1.9	2.5	3.0	2.4
Number of operations (self-reported)	1.7	2.6	7.1	2.7	1.6	0.0	1.4	1.7	1.4	1.0	1.6	0.3	2.3	2.0	1.7	1.5
Arm predicted mass (left)	1.7	8.5	13.9	3.7	3.4	2.8	3.1	3.2	3.3	2.9	3.2	1.6	2.0	2.6	3.0	2.4
Smoking Status	1.6	3.7	9.4	1.5	1.7	1.0	2.5	2.6	1.8	3.1	2.5	2.3	-0.4	0.5	1.9	1.2
Systolic blood pressure, automated reading	1.6	4.6	7.7	2.7	2.3	-0.8	2.6	2.3	0.5	1.4	2.3	0.1	2.2	2.7	2.8	2.7
Diabetes (father)	1.6	2.0	6.7	-1.3	-0.8	-0.0	-1.7	-1.7	-2.6	-2.0	-1.6	-1.7	0.4	-0.3	-0.8	-0.7
Impedance of leg (left)	1.6	7.8	14.3	-3.6	-3.8	-0.8	-2.7	-2.6	-3.5	-1.6	-2.6	-0.2	-2.9	-3.2	-3.3	-2.8
Qualifications: None of the above	1.6	3.4	6.8	2.1	1.9	-0.3	1.7	1.9	0.8	0.8	1.8	1.2	2.4	2.6	2.1	2.5
Happiness	1.6	2.0	5.9	1.8	2.4	0.7	0.7	1.1	-0.2	0.6	1.1	-0.7	2.0	1.7	1.6	1.8
Overall health rating	1.6	3.4	9.8	1.8	2.3	3.1	1.4	1.3	0.2	0.3	1.3	-1.4	2.1	2.2	2.2	2.0
Ever had bowel cancer screening	1.6	1.9	4.1	1.9	1.5	0.4	1.2	1.3	0.5	0.2	1.2	-0.2	1.9	2.0	1.3	1.9
Friendships satisfaction	1.6	2.0	3.8	1.4	1.6	1.4	0.9	1.2	-0.7	0.6	1.2	-1.8	2.0	1.9	1.7	1.5
Basal cell carcinoma (self-reported)	1.6	1.9	4.8	-2.2	-1.2	-0.5	-1.1	-1.3	-2.1	-0.6	-1.2	0.7	-1.4	-1.5	-1.5	-1.4
Bipolar Disorder (2018)	1.5	2.4	4.6	1.8	2.1	0.2	1.9	1.9	-0.5	1.9	1.9	0.9	0.3	0.8	1.9	1.6
Blood Eosinophil Count	1.5	11.4	39.7	-2.3	-1.6	0.4	3.2	3.7	6.3	6.0	3.7	-2.7	-3.8	-1.7	1.1	-0.7
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	5.1	-2.2	-1.2	-0.2	-0.8	-1.1	-1.1	-0.5	-1.0	-1.2	-1.6	-1.7	-1.5	-1.6
Comparative body size at age 10	1.5	4.2	7.2	2.2	2.4	1.3	2.2	2.4	1.2	2.0	2.3	2.7	1.4	1.8	2.4	1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	6.1	-1.7	-1.6	-0.8	-1.1	-1.1	-2.5	-0.9	-1.2	-1.3	-1.0	-1.2	-1.0	-1.3
Financial situation satisfaction	1.5	1.8	4.8	1.4	1.3	1.3	0.6	0.6	0.8	-0.4	0.6	-1.0	2.2	2.1	1.5	1.9
Ever smoked	1.5	2.6	5.4	1.6	1.6	1.3	1.7	1.8	2.3	1.7	1.8	1.0	1.2	1.4	1.8	1.6
Irritability	1.5	2.5	5.2	-2.0	-0.8	1.5	-1.9	-1.8	-1.1	-1.7	-1.8	-2.3	-0.6	-1.4	-1.4	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	3.7	1.9	1.8	-1.5	1.4	1.6	-0.2	1.3	1.5	1.2	0.2	0.7	1.3	1.5
LDL Cholesterol	1.4	2.2	4.9	-1.9	-2.2	-0.5	-1.0	-1.2	-0.6	-0.7	-1.1	-0.6	-1.8	-1.9	-1.8	-2.2
Supplements: Zinc	1.4	1.5	3.3	-1.0	-0.4	1.4	-1.8	-1.7	-0.3	-1.8	-1.7	-0.3	-0.2	-0.9	-1.4	-0.7
Weight	1.4	6.7	12.0	3.5	3.4	2.4	2.3	2.5	3.2	2.0	2.5	1.2	2.1	2.4	2.9	2.3
Arm fat percentage (right)	1.4	5.6	10.7	3.3	3.3	0.7	1.9	2.0	1.6	0.7	1.9	-0.5	3.1	3.2	3.0	2.8
Alcohol intake versus 10 years previously	1.4	2.0	4.2	0.9	2.0	0.9	1.5	1.6	1.4	1.5	1.6	1.3	0.8	1.1	2.0	1.4
Leg fat percentage (right)	1.4	5.0	11.2	3.3	3.0	1.2	1.9	2.0	0.5	0.9	1.9	-0.2	2.8	2.9	2.8	2.6
Qualifications: College or University degree	1.4	4.5	10.7	-3.3	-1.7	2.1	-1.7	-1.6	-2.2	-0.4	-1.6	0.8	-2.8	-2.9	-1.9	-2.5
Medication for pain relief, constipation, heartburn	1.4	2.5	9.2	-3.0	-1.8	-0.2	-0.7	-0.7	-0.6	0.6	-0.7	0.7	-2.6	-2.3	-1.5	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	3.5	1.9	1.3	1.6	1.4	1.6	1.0	1.3	1.5	0.7	0.5	1.0	1.5	0.9
Mood swings	1.4	2.6	3.9	-1.3	-1.7	-0.3	-2.0	-1.9	-1.6	-1.8	-1.9	-1.7	-0.6	-1.2	-2.0	-1.9
Leg fat percentage (left)	1.4	5.2	12.3	3.5	3.1	1.2	1.9	2.0	0.4	0.9	2.0	-0.1	2.8	2.9	2.8	2.8
Neuroticism	1.3	3.1	5.3	-1.6	-1.3	0.9	-2.2	-2.3	-1.7	-2.2	-2.2	-1.4	-1.0	-1.7	-2.0	-1.4
Hair/balding pattern: Pattern 2	1.3	1.7	3.5	-1.4	-0.8	0.5	-1.8	-1.6	-1.6	-1.9	-1.7	-1.4	-0.2	-0.5	-1.1	-1.1
Medication: Ramipril	1.3	1.6	5.1	1.3	1.6	1.0	0.8	0.7	-0.1	-0.1	0.8	-0.5	2.3	1.7	1.4	1.9
Neuroticism score	1.3	2.7	4.3	-1.6	-1.2	0.5	-1.9	-2.1	-1.4	-1.8	-2.0	-1.7	-1.2	-1.9	-1.9	-1.5
Number of live births	1.3	1.8	7.3	1.4	0.7	2.7	0.9	0.9	1.0	0.2	0.9	0.7	1.6	1.9	1.3	1.5
Hair/balding pattern: Pattern 4	1.3	3.2	5.0	2.0	2.1	0.5	2.0	2.1	1.7	2.0	2.1	1.3	0.9	1.5	2.2	1.8
Health satisfaction	1.3	1.7	3.7	1.1	1.2	1.9	1.6	1.4	0.5	1.1	1.5	-0.6	1.1	1.3	1.3	1.5
Medication: Blood pressure	1.3	2.3	4.5	1.8	2.1	0.0	1.5	1.5	-0.1	0.8	1.5	0.6	1.9	1.7	2.1	1.9
Arm predicted mass (right)	1.3	6.8	11.5	3.2	3.0	3.0	2.6	2.8	3.4	2.6	2.7	1.7	1.6	2.1	2.5	1.9
Number of full sisters	1.3	1.6	3.2	1.1	1.8	-0.3	1.4	1.6	0.4	1.1	1.6	0.5	1.0	1.4	1.6	1.4
Arm fat percentage (left)	1.3	5.0	10.0	3.2	3.1	0.8	1.8	1.9	1.5	0.7	1.8	-0.3	2.9	3.0	2.9	2.6
Average weekly red wine intake	1.3	1.9	5.5	-1.7	-2.4	-0.1	-1.1	-1.3	-0.7	-0.4	-1.2	0.2	-1.8	-1.6	-1.8	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	4.0	1.9	1.3	0.8	1.1	1.4	1.9	0.6	1.3	-0.5	1.8	1.8	1.5	2.0
Miserableness	1.3	2.2	5.2	-1.7	-1.3	-0.5	-1.5	-1.4	-1.2	-0.6	-1.4	-0.9	-2.2	-2.3	-1.9	-1.3
Unable to work because of sickness or disability	1.3	1.7	3.6	1.1	1.1	0.4	1.9	1.9	0.9	1.8	1.9	-0.3	0.6	0.9	1.6	1.0
Crohns Disease (2017)	1.2	2.7	6.1	1.8	2.5	0.3	1.5	1.5	1.6	1.0	1.7	0.8	1.5	1.6	2.0	2.1
Ovarian Cancer	1.2	1.5	4.2	1.4	2.0	-0.3	0.5	0.7	-0.2	0.1	0.6	1.4	2.0	1.8	1.5	1.2
Ulcerative Colitis	1.2	1.7	2.7	-1.5	-0.9	1.2	-1.4	-1.3	-1.0	-0.8	-1.4	-1.1	-1.5	-1.6	-1.2	-1.6
Lung FVC	1.2	6.1	9.9	1.6	1.8	2.8	3.1	3.1	2.4	3.0	3.1	2.4	0.5	1.8	2.6	2.4
Medication for hormone replacement therapy	1.2	1.3	3.8	-1.0	-0.3	1.6	0.7	0.6	0.1	1.7	0.6	1.6	-1.9	-1.5	-0.4	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	4.2	-2.0	-0.8	1.9	-1.7	-1.7	-0.7	-1.6	-1.7	-0.2	-0.8	-1.3	-1.5	-1.0
Arm fat-free mass (right)	1.2	6.3	10.1	3.2	3.1	2.9	2.5	2.7	3.0	2.6	2.7	1.7	1.4	1.9	2.4	1.8
Age at first live birth	1.2	2.1	3.7	-1.7	-1.3	-0.8	-1.8	-1.9	-1.1	-1.9	-1.9	-0.7	-0.4	-1.0	-1.7	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	2.8	0.1	1.7	-0.3	1.4	1.3	0.7	1.7	1.3	1.1	-0.5	-0.0	1.4	1.1
Basal metabolic rate	1.2	6.4	12.5	3.2	3.2	2.5	2.4	2.6	3.5	2.4	2.6	1.5	1.6	2.1	2.6	1.8
Depression (Nagel 2018)	1.1	1.7	3.7	1.9	1.3	-0.6	1.2	1.3	0.9	0.4	1.3	-0.5	1.4	1.6	1.5	1.7
Intelligence (Savage-Jansen 2018)	1.1	3.5	8.5	-1.9	-1.6	0.2	-1.5	-1.6	-2.9	-0.5	-1.6	-0.2	-2.5	-2.5	-2.1	-2.4
Crohns Disease (2012)	1.1	1.7	3.8	1.0	1.9	-0.7	1.1	1.3	0.9	0.8	1.6	0.3	1.3	1.5	1.7	1.8
HDL Cholesterol	1.1	1.8	3.8	-1.7	-2.0	0.7	-1.2	-1.6	-1.5	-1.2	-1.4	0.2	-0.8	-1.1	-1.9	-1.4
Diabetes (mother)	1.1	1.4	5.2	1.1	1.1	2.3	0.6	0.4	1.3	-0.3	0.4	-0.8	1.8	1.6	1.0	1.2
Serious illness, injury or assault to yourself	1.1	1.4	3.1	-1.0	-0.7	0.8	-1.6	-1.5	-1.8	-1.4	-1.6	-0.6	-0.3	-0.8	-1.1	-0.9
Hayfever, allergic rhinitis or eczema	1.1	2.4	4.8	1.3	0.8	1.1	2.2	2.1	1.6	2.0	2.1	0.4	0.7	1.4	1.5	1.8
Past tobacco smoking	1.1	2.0	3.4	-0.8	-1.1	-1.8	-1.6	-1.7	-1.8	-1.9	-1.7	-1.2	-0.6	-0.8	-1.5	-1.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.3	-0.0	0.4	1.6	1.6	1.5	1.8	1.6	1.6	0.5	-0.5	0.3	1.1	1.1
Mouth/teeth dental problems: Dentures	1.1	1.9	5.1	1.4	1.2	-2.2	1.4	1.2	-1.1	0.6	1.3	0.3	1.6	1.6	1.3	1.7
Trunk predicted mass	1.1	6.0	9.8	3.0	2.9	2.7	2.5	2.7	3.1	2.6	2.7	1.8	1.3	1.9	2.4	1.5
Medication: Ibuprofen	1.1	1.3	4.4	1.8	0.9	-0.6	-0.0	0.0	1.5	-0.9	-0.0	-0.0	2.1	1.9	0.8	1.0
Qualifications: nursing, teaching	1.1	1.7	3.2	-1.2	-1.3	1.1	-1.3	-1.3	0.0	-0.8	-1.4	-0.7	-1.6	-1.7	-1.6	-1.8
Whole body water mass	1.1	6.3	12.8	3.0	3.0	2.8	2.5	2.6	3.6	2.5	2.6	1.6	1.4	1.9	2.4	1.7
Lupus	1.0	1.5	3.2	0.9	0.9	-0.9	1.8	1.8	0.6	1.8	1.8	0.8	0.2	0.9	1.2	1.1
Waist Hip Ratio (WHR)	1.0	4.5	12.7	3.6	2.5	-0.4	1.4	1.7	-0.3	0.4	1.7	-1.1	3.3	2.8	2.3	2.6
Allergy or Eczema	1.0	2.7	6.0	0.9	1.1	0.4	2.5	2.4	1.2	2.2	2.4	0.6	0.6	1.4	1.7	1.9
Frequency of depressed mood in last 2 weeks	1.0	1.3	3.8	1.9	1.8	0.5	0.7	1.0	0.6	0.4	0.9	-0.8	1.3	1.3	1.5	1.1
Severe depression (siblings)	1.0	1.1	2.1	-1.0	-1.3	0.5	-1.1	-1.3	0.2	-1.1	-1.2	-0.7	-0.7	-1.2	-1.4	-1.2
Trunk fat-free mass	1.0	6.0	9.8	3.0	2.9	2.7	2.4	2.6	3.1	2.6	2.6	1.7	1.3	1.8	2.4	1.5
Lung cancer (father)	1.0	1.2	2.5	-0.8	-1.3	-1.4	-0.8	-0.6	0.5	0.1	-0.7	-1.1	-1.6	-1.5	-1.3	-1.4
Illnesses of mother	1.0	1.3	4.6	-0.9	-0.6	-0.9	0.5	0.6	0.7	1.5	0.6	1.9	-2.1	-1.3	-0.6	-0.7
Tense / ‘highly strung’	1.0	1.6	4.6	-1.6	-0.9	2.1	-0.5	-0.7	0.0	0.0	-0.6	0.1	-2.1	-2.1	-1.2	-1.3
Eye problems/disorders: None of the above	1.0	1.1	2.4	-1.4	-1.5	0.6	-0.7	-0.8	0.6	-0.3	-0.8	0.5	-1.4	-1.3	-1.3	-1.6
Medication: Seretide 50 evohaler	1.0	1.1	2.6	0.3	0.7	0.9	1.6	1.4	0.9	1.3	1.5	-0.0	0.4	0.8	1.1	1.2
Commuting to job workplace: Car/motor vehicle	1.0	1.1	4.5	1.4	0.6	-0.9	0.9	0.8	2.1	0.4	0.8	-0.2	0.9	1.2	0.9	1.2
Whole body fat-free mass	1.0	5.7	12.1	3.0	2.9	2.6	2.3	2.5	3.5	2.3	2.5	1.5	1.5	1.9	2.3	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	3.3	1.0	1.0	-0.1	1.3	1.3	-1.1	1.6	1.3	1.8	-0.1	0.4	0.7	-0.3
Commuting to job workplace: Public transport	1.0	1.2	2.4	-1.4	-0.8	-0.2	-1.5	-1.4	-1.2	-1.4	-1.5	-0.7	-0.6	-1.0	-1.0	-0.9
Eye problems/disorders: Glaucoma	1.0	1.2	3.1	1.2	0.9	1.0	1.2	1.1	0.3	0.6	1.1	-0.6	1.4	1.8	1.2	1.0
Risk taking	1.0	1.4	1.9	1.4	1.3	1.0	1.2	1.2	1.0	0.8	1.2	1.1	1.4	1.3	1.3	0.9
Ever depressed for a whole week	1.0	1.3	3.1	1.0	1.3	1.8	0.9	1.1	-0.2	0.3	1.0	-0.2	1.4	1.3	1.2	1.6
Neuroticism (Nagel 2018)	0.9	2.2	4.2	-1.1	-1.4	0.2	-1.9	-2.0	-1.5	-2.1	-1.9	-1.1	-0.8	-1.2	-1.6	-1.0
Bipolar Disorder (2011)	0.9	0.8	2.6	0.2	0.7	-0.8	1.1	1.1	-0.9	1.6	0.9	1.1	-0.8	-0.2	0.9	0.7
Leg fat-free mass (left)	0.9	4.5	13.8	2.6	2.7	2.0	1.8	2.0	3.7	1.7	2.0	0.9	1.5	1.8	2.1	1.4
Had menopause	0.9	1.2	2.6	1.1	0.4	0.1	1.6	1.4	0.5	1.0	1.4	1.0	0.7	1.3	1.1	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.1	1.0	0.3	-0.1	-1.0	-0.9	1.1	-1.8	-0.9	-1.3	1.8	1.2	-0.1	0.3
Medication: Amlodipine	0.9	1.2	2.5	1.4	1.5	1.2	1.0	1.0	-1.2	0.5	1.0	0.4	1.0	1.0	1.6	1.0
Number of children fathered	0.9	1.0	4.2	0.5	0.3	0.7	0.9	1.1	0.3	1.7	1.0	2.0	-1.4	-0.6	0.4	-0.2
Whole body fat mass	0.9	3.9	7.9	2.8	2.7	1.6	1.7	1.8	1.8	1.1	1.8	0.1	2.1	2.2	2.4	1.9
Leg fat-free mass (right)	0.9	4.9	15.2	2.5	2.8	2.4	2.0	2.2	3.9	2.0	2.1	1.3	1.2	1.6	2.1	1.4
Eye problems/disorders: Cataract	0.9	1.0	2.3	0.6	1.0	-1.2	1.1	1.0	-0.2	0.9	1.1	1.3	0.7	0.8	1.0	1.5
Leg predicted mass (right)	0.9	4.8	14.5	2.5	2.8	2.4	1.9	2.1	3.8	2.0	2.1	1.2	1.3	1.6	2.1	1.5
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.4	1.7	-0.5	-0.3	-1.0	-0.8	-0.1	-1.7	-0.9	0.6	1.8	1.0	-0.5	-0.1
Illnesses of father: High blood pressure	0.9	1.2	2.4	0.6	1.4	-1.2	1.0	1.2	-0.1	1.0	1.2	0.5	1.3	1.0	1.2	1.6
Neuroticism (2016)	0.8	1.1	2.3	-0.8	-0.2	-1.5	-1.4	-1.4	-1.0	-1.4	-1.4	-0.5	-0.5	-1.1	-1.1	-0.3
Blood White Count	0.8	6.1	16.9	4.1	2.7	2.7	2.0	2.0	1.4	1.4	2.0	2.9	2.5	2.5	2.9	1.7
Heel T-Score	0.8	6.5	13.8	-3.5	-2.7	-0.6	-2.5	-2.4	-3.7	-1.5	-2.5	-2.1	-2.4	-2.6	-2.5	-2.7
Sensitivity / hurt feelings	0.8	1.4	2.8	-1.0	-0.7	0.7	-1.7	-1.7	-0.5	-1.6	-1.6	-0.8	-0.7	-1.1	-1.5	-0.7
Current tobacco smoking	0.8	1.4	4.5	0.0	0.6	0.2	1.6	1.6	1.8	2.1	1.6	0.8	-0.8	-0.2	0.7	0.2
Leg predicted mass (left)	0.8	4.3	13.2	2.5	2.6	2.0	1.8	2.0	3.6	1.7	1.9	0.9	1.4	1.7	2.0	1.4
Mouth/teeth dental problems	0.8	1.2	4.7	-1.2	-0.7	-0.5	-0.6	-0.6	0.5	0.4	-0.7	0.9	-2.2	-1.8	-0.7	-1.5
Diabetes (self-reported)	0.8	1.3	11.9	-0.3	0.1	3.4	0.4	0.2	-1.9	0.4	0.2	-0.0	-0.1	-0.2	0.5	-0.4
Pulse rate	0.8	1.3	3.9	-1.5	-1.0	0.8	-0.2	-0.2	-2.0	0.6	-0.2	0.7	-1.7	-1.5	-1.0	-1.5
Length of working week for main job	0.8	0.9	6.0	-1.1	-0.4	2.5	-0.3	-0.1	-0.5	0.4	-0.1	1.6	-0.3	-0.5	-0.3	-0.7
Peak expiratory flow (PEF)	0.8	1.7	5.2	-0.1	-1.0	1.6	0.4	0.3	2.3	1.3	0.3	1.6	-2.3	-1.4	-0.3	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.3	0.5	1.5	1.5	0.9	1.0	0.0	1.2	1.0	1.5	-0.5	-0.2	0.9	1.0
Heart disease (mother)	0.8	1.0	2.9	0.3	1.1	1.1	0.9	0.5	0.4	-0.4	0.6	-0.5	1.7	1.6	1.2	1.3
Family relationship satisfaction	0.8	1.0	2.2	1.2	1.5	1.3	0.1	0.4	-0.4	-0.1	0.4	0.9	1.5	1.3	1.1	1.1
Smoking status: Previous	0.8	1.2	2.6	0.8	1.1	1.4	1.2	1.4	0.5	1.6	1.3	1.1	0.3	0.6	1.5	0.9
Diabetes diagnosed by doctor	0.8	1.4	11.3	-0.8	-0.6	3.4	-0.2	-0.3	-1.9	-0.0	-0.3	0.0	-0.5	-0.6	-0.0	-1.0
Smoking status: Current	0.8	1.2	3.9	-0.1	0.4	0.4	1.4	1.4	1.9	2.0	1.4	0.9	-0.9	-0.3	0.5	0.1
Ever taken oral contraceptive pill	0.8	0.9	3.3	0.9	0.8	1.8	1.1	1.1	-0.0	1.6	1.1	0.7	-0.4	-0.1	0.9	-0.1
Pain type(s) experienced in last month: Hip pain	0.8	1.1	2.0	1.1	1.4	1.3	0.7	0.7	0.6	-0.1	0.6	1.0	1.3	1.2	1.0	1.4
Medication: Lisinopril	0.8	1.0	3.4	1.2	1.1	-0.2	0.5	0.6	0.0	-0.3	0.5	-0.2	1.9	1.7	1.2	1.3
Supplements: Calcium	0.8	0.9	3.1	0.4	-0.3	1.6	-1.1	-1.0	-0.5	-1.8	-1.1	-0.6	1.2	0.5	-0.5	-0.1
Heart disease (siblings)	0.8	0.9	2.6	1.5	0.6	-1.1	0.2	0.3	-0.3	-0.8	0.2	-0.8	1.6	1.6	0.4	1.2
Reaction Time	0.7	1.4	3.0	-1.0	-1.3	0.8	-1.3	-1.3	0.5	-1.3	-1.3	-0.8	-0.5	-1.0	-1.7	-1.5
Fasting Glucose	0.7	0.8	3.0	1.0	0.9	1.7	0.6	0.6	-0.1	0.2	0.5	1.1	0.9	0.7	1.0	1.3
Relative age voice broke	0.7	1.1	3.1	0.4	0.4	-1.7	-0.7	-0.8	-0.9	-1.8	-0.8	-1.5	1.3	1.0	-0.2	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	4.4	-1.0	-0.9	-1.0	-1.6	-1.6	-2.1	-1.3	-1.6	0.5	-1.1	-1.3	-1.1	-1.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.1	0.4	1.1	0.7	1.0	1.3	0.0	1.5	1.3	1.0	-0.1	0.2	0.9	0.9
Falls in the last year	0.7	1.0	4.3	-2.1	-0.5	0.6	-0.8	-1.0	-0.4	-0.7	-1.0	-1.1	-0.8	-1.0	-1.1	-0.7
Loud music exposure frequency	0.7	0.8	1.6	1.1	1.0	-0.5	1.1	1.2	0.5	1.3	1.2	0.2	0.4	0.6	1.0	0.5
Birth weight	0.7	1.6	3.8	1.7	1.1	-1.5	1.2	1.2	1.5	1.2	1.2	1.9	0.5	1.0	0.9	0.7
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.9	-1.0	-0.9	0.6	-1.1	-0.9	-0.9	-0.7	-1.0	-0.7	-0.5	-0.8	-0.8	-1.4
Mean time to correctly identify matches	0.7	1.3	2.8	-0.9	-1.5	0.6	-1.1	-1.1	-0.7	-1.1	-1.2	-1.2	-0.7	-1.0	-1.7	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	6.1	0.6	1.1	-2.5	0.5	0.5	0.4	0.4	0.4	-0.7	-0.3	-0.0	1.0	0.8
Pulse rate, automated reading	0.7	2.2	6.3	-1.8	-1.6	1.0	-0.0	-0.0	-1.9	1.2	0.1	-0.1	-2.5	-2.2	-1.3	-2.0
Alcohol intake frequency.	0.7	1.6	3.9	1.0	1.9	-0.9	1.1	1.1	-0.1	0.5	1.1	-1.0	1.2	1.3	1.7	2.0
Suffer from ‘nerves’	0.7	1.0	4.0	-0.3	-0.4	-0.1	-1.1	-1.3	-0.2	-2.0	-1.2	-2.0	0.9	0.3	-0.3	-0.4
Body Mass Index (BMI) (2010)	0.6	0.8	2.4	0.8	1.2	1.6	0.8	0.9	0.8	0.7	0.8	0.3	0.6	0.6	1.1	0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.2	1.1	0.6	0.2	0.4	0.2	-1.4	-0.4	0.2	-0.7	1.5	1.2	0.7	0.5
Medication: Metformin	0.6	0.8	5.4	-0.3	0.1	1.4	-0.1	0.0	-2.3	0.4	-0.0	-1.2	-0.5	-0.5	0.5	-0.6
Qualifications: CSEs or equivalent	0.6	0.8	3.5	1.2	0.0	-1.6	0.1	0.1	1.9	-0.1	0.1	-1.2	0.8	0.7	0.3	0.5
Forced vital capacity (FVC)	0.6	2.3	7.2	-0.5	-0.6	2.7	0.1	0.4	2.4	1.4	0.3	2.6	-2.1	-1.3	-0.3	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.5	-1.3	-0.5	-0.4	-1.6	-1.6	-1.6	-1.4	-1.6	0.6	-0.8	-1.0	-0.8	-0.7
Hip circumference	0.6	2.4	5.9	2.0	2.0	1.5	1.3	1.5	2.4	1.1	1.4	0.5	1.2	1.5	1.6	1.1
Noisy workplace	0.6	0.7	2.1	-0.4	-0.9	0.6	-1.0	-1.1	-1.0	-1.5	-1.1	-0.4	0.6	0.1	-0.8	-0.4
Medication: Lansoprazole	0.6	0.7	3.8	1.9	0.4	-0.8	0.6	0.8	-0.5	0.3	0.7	0.1	0.9	1.0	1.0	0.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.5	-1.6	-1.9	-0.3	-0.8	-0.8	0.4	-0.5	-0.8	-0.5	-1.0	-0.8	-1.4	-1.2
Neck or shoulder pain in last month	0.6	0.8	2.0	-1.0	-0.4	0.8	-1.1	-0.9	-0.6	-0.5	-1.0	0.8	-1.4	-1.4	-1.0	-0.4
Chest pain or discomfort	0.6	0.8	9.4	-0.5	0.5	3.1	0.3	0.2	0.5	0.1	0.3	0.2	0.2	0.1	0.4	-0.2
Medication: Aspirin	0.6	0.7	2.0	1.4	1.0	0.4	0.1	0.0	-0.6	-0.7	0.0	-1.3	1.4	0.9	0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.5	-0.4	-0.9	1.2	-0.9	-0.5	1.9	0.3	-0.6	1.4	-1.7	-1.4	-0.9	-1.2
Loneliness, isolation	0.6	0.9	2.2	1.0	1.3	-1.2	0.5	0.4	-0.6	-0.1	0.5	-0.1	1.5	1.3	0.8	1.4
Medication: Aspirin	0.6	0.8	2.6	1.6	1.2	0.2	0.2	0.2	-0.7	-0.5	0.2	-0.8	1.4	1.0	1.0	0.9
Medication: Gliclazide	0.6	0.7	1.5	-0.9	-0.8	1.2	0.2	-0.1	-0.9	0.5	0.0	-1.2	-1.1	-1.0	-0.0	-1.1
Medication: Atorvastatin	0.6	0.7	3.5	-0.3	-0.6	1.9	-0.8	-0.8	0.2	-0.9	-0.8	-1.3	-0.0	-0.3	-0.5	-0.6
Alcohol drinker status: Never	0.6	0.7	2.9	-0.1	-0.1	0.3	-0.3	-0.3	0.8	-1.3	-0.3	-1.3	1.7	1.3	0.3	0.7
Commuting to job workplace: Cycle	0.6	0.7	3.7	1.0	-0.4	-0.6	-0.5	-0.5	-1.9	-1.2	-0.5	-0.4	0.9	0.7	0.0	0.1
Depressed Affect (Nagel 2018)	0.5	0.9	4.0	-0.6	-0.6	-0.9	-1.1	-1.0	-2.0	-0.9	-1.0	-0.9	-0.5	-0.8	-1.0	-0.5
Major Depression (MDD)	0.5	0.7	2.6	1.1	1.6	0.3	0.1	0.2	1.5	-0.2	0.2	-1.0	0.6	0.4	0.5	0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.3	-1.0	-1.3	0.1	-0.7	-0.8	-2.1	-0.1	-0.8	0.3	-1.4	-1.3	-1.3	-1.2
Mean Putamen Volume	0.5	0.6	3.2	0.8	-0.1	1.8	-0.0	0.2	0.2	-0.2	0.1	1.2	0.9	0.8	0.5	0.4
Angina	0.5	0.6	2.4	0.8	1.2	1.5	-0.2	-0.0	0.4	-0.7	-0.1	0.3	1.2	0.9	0.6	0.7
Townsend deprivation index at recruitment	0.5	0.7	3.3	0.2	0.8	1.8	0.6	0.8	-0.4	0.8	0.8	-0.8	0.4	0.3	1.0	0.0
Fed-up feelings	0.5	0.8	1.8	-0.3	-0.4	-0.5	-1.4	-1.1	-1.1	-0.8	-1.0	-0.8	-0.7	-1.1	-1.2	-0.8
Stomach or abdominal pain in last month	0.5	0.6	1.1	0.8	0.9	0.8	0.6	0.7	0.2	0.1	0.7	-0.8	0.7	0.8	1.1	0.9
Trunk fat mass	0.5	2.0	3.9	2.0	2.0	1.8	0.9	1.1	1.6	0.7	1.1	0.2	1.4	1.4	1.6	1.2
Nervous feelings	0.5	0.9	3.4	-0.6	-0.3	1.2	-0.9	-1.0	-1.1	-1.0	-0.9	-1.8	-0.6	-0.9	-0.4	-0.1
Financial difficulties in last 2 years	0.5	0.7	2.0	0.4	-0.8	0.6	-0.9	-0.9	0.8	-1.1	-0.9	-1.4	-0.3	-0.4	-0.8	-0.5
Worrier / anxious feelings	0.5	0.9	2.9	-0.9	-0.3	0.8	-1.3	-1.3	-0.2	-1.7	-1.2	-1.4	0.5	-0.3	-0.6	-0.2
Depression (self-reported)	0.5	0.6	1.7	-0.8	-0.2	-0.5	-0.8	-0.8	-1.3	-0.9	-0.8	-1.1	-0.3	-0.5	-0.3	-0.6
Standing height	0.5	4.8	11.2	-2.2	-1.9	2.5	-1.4	-1.0	1.6	0.7	-1.0	2.2	-3.3	-3.1	-2.2	-3.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	0.2	1.1	1.1	0.7	0.9	-0.1	1.1	0.8	1.0	-0.1	0.3	0.7	0.4
Forced vital capacity (FVC), Best measure	0.5	1.9	6.1	-0.2	-0.7	2.5	0.2	0.5	2.2	1.6	0.5	2.1	-1.9	-1.3	-0.2	-0.9
Body fat percentage	0.5	1.8	4.1	2.0	2.0	1.1	0.9	1.0	0.7	0.3	0.9	-0.2	1.8	1.7	1.7	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	3.0	0.5	-0.8	-0.3	-0.6	-0.5	1.7	-0.9	-0.5	-1.0	0.8	0.7	-0.4	-0.3
Illnesses of siblings: Diabetes	0.5	0.6	2.3	0.5	1.5	0.5	0.2	0.1	-0.9	-0.6	0.1	-0.4	0.7	0.8	1.1	1.3
Guilty feelings	0.5	0.8	2.8	0.2	-0.9	0.1	-0.9	-0.8	-1.7	-0.8	-0.8	1.5	-0.2	-0.7	-0.5	-0.7
Hearing aid user	0.5	0.6	3.0	-0.6	-0.3	-0.9	-0.4	-0.6	-1.7	-0.6	-0.6	-0.0	-0.7	-0.7	-1.0	-0.4
Diastolic blood pressure, automated reading	0.5	1.6	4.1	1.0	1.0	-0.5	1.9	1.8	0.2	2.0	1.8	0.8	-0.2	0.6	1.4	0.9
Pain experienced in last month	0.5	0.8	2.3	1.1	0.4	-1.5	0.7	0.6	-0.6	0.1	0.6	-0.1	1.5	1.3	0.8	0.5
Worry (Nagel 2018)	0.4	0.9	1.9	-1.0	-0.7	1.0	-0.9	-1.1	-0.6	-1.3	-1.1	-1.4	-0.4	-1.0	-0.6	-0.5
Ulcerative Colitis (UC)	0.4	0.7	2.4	-0.7	-0.1	1.5	-1.0	-0.8	-0.8	-0.7	-0.9	-0.4	-0.5	-0.8	-0.6	-0.9
Age at First Birth	0.4	0.6	1.4	-0.8	-1.2	0.2	-0.7	-0.8	-1.1	-0.8	-0.7	-0.6	-0.1	-0.2	-0.8	-0.7
HbA1C	0.4	0.4	1.9	-0.5	0.1	-1.0	-0.6	-0.4	-1.0	-0.1	-0.3	1.4	-0.7	-0.7	-0.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.3	1.0	0.6	1.0	0.1	0.5	-0.3	0.3	0.2	-1.2	0.8	0.5	0.2	0.4
Hypothyroidism (self reported)	0.4	0.9	2.2	-1.5	-1.2	-1.2	-0.8	-0.8	-1.1	-0.5	-0.8	-0.2	-0.6	-0.6	-1.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	8.0	-0.4	0.1	2.8	-0.1	-0.1	-0.7	0.2	-0.1	0.3	-0.3	-0.5	0.2	-0.3
Vitamin and mineral supplements	0.4	0.5	0.9	0.2	0.6	-0.9	0.8	0.8	0.9	0.8	0.9	-0.3	0.3	0.5	1.0	0.1
Maternal smoking around birth	0.4	0.6	1.9	0.3	0.2	-0.4	1.3	0.9	0.6	1.4	1.0	0.5	-0.7	-0.5	0.6	-0.4
Hearing difficulty/problems with background noise	0.4	0.7	2.5	-0.1	0.4	1.2	-0.8	-0.5	-1.6	-1.1	-0.5	-1.5	0.7	0.2	0.0	0.4
Medication: Simvastatin	0.4	0.6	2.4	-0.2	-0.2	-0.3	-0.9	-0.9	-1.5	-0.9	-0.9	-1.2	-0.3	-0.7	-0.5	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.3	-0.7	-1.1	0.4	-0.2	-0.2	0.9	-0.0	-0.3	-0.1	-1.1	-0.9	-0.6	-0.9
Prospective memory result	0.4	0.4	1.1	0.7	0.1	1.0	0.6	0.5	0.9	0.1	0.5	0.2	0.9	1.0	0.5	0.6
Pulse wave reflection index	0.4	0.5	1.3	0.1	1.1	-0.0	0.9	0.6	0.1	0.2	0.7	-0.2	0.8	0.9	0.6	1.2
Exposure to tobacco smoke outside home	0.4	0.6	2.1	0.5	1.0	0.2	0.3	0.2	0.0	-0.3	0.3	-1.0	1.5	1.0	0.8	0.9
Shortness of breath walking on level ground	0.4	0.5	2.2	0.0	0.7	0.9	0.6	0.5	-0.9	0.4	0.5	-1.5	0.5	0.5	0.5	0.2
Angina (self-reported)	0.4	0.6	1.7	0.8	1.3	1.2	-0.3	-0.2	0.3	-0.8	-0.2	0.1	1.0	0.7	0.6	0.7
Migraine (self-reported)	0.4	0.5	3.3	-0.0	0.8	1.8	0.3	0.3	-0.9	-0.1	0.3	-0.4	0.5	0.6	0.6	0.9
Illnesses of father: Heart disease	0.4	0.6	1.6	0.5	0.7	-0.3	0.8	0.8	0.0	0.5	0.8	0.0	1.1	1.1	1.2	1.0
Breast cancer (self-reported)	0.4	0.5	2.5	-0.1	0.2	1.1	0.3	0.4	-0.3	0.8	0.3	1.6	-0.9	-0.7	0.1	-0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	0.4	0.5	-0.0	0.9	0.5	-1.0	0.3	0.7	-0.3	1.0	0.6	0.6	0.6
Breast Cancer	0.3	0.7	2.5	-0.1	0.1	-0.8	-0.8	-0.7	0.2	-1.6	-0.7	0.2	1.6	1.1	-0.2	0.2
Triglycerides	0.3	0.5	0.8	-0.8	-0.5	0.6	-0.9	-0.6	0.6	-0.6	-0.6	0.6	-0.8	-0.9	-0.7	-0.6
Height	0.3	4.9	14.1	-1.8	-2.3	1.7	-1.3	-0.9	0.8	1.1	-0.9	2.3	-3.8	-3.3	-2.4	-3.3
Tanning	0.3	3.6	8.6	2.9	2.7	0.6	1.2	1.4	0.9	0.2	1.3	0.3	2.8	2.7	2.1	2.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	2.1	-0.2	-0.2	-0.6	0.4	0.4	1.5	0.1	0.4	-0.8	0.6	0.5	0.2	0.4
Multivitamins +/- minerals	0.3	0.4	1.3	0.1	-0.4	0.7	-0.7	-0.6	-1.1	-0.9	-0.7	-0.5	0.4	0.2	-0.4	0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	2.4	-0.4	-0.7	-1.6	0.0	-0.2	-0.4	0.0	-0.2	-0.6	-0.8	-0.7	-0.3	-0.5
Sitting height	0.3	2.5	7.4	-0.6	-0.1	2.7	0.3	0.7	2.6	1.9	0.7	2.3	-2.1	-1.5	-0.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.6	-0.8	-0.3	0.1	-0.7	-0.5	0.3	-0.2	-0.5	0.3	-1.0	-1.2	-0.8	-0.8
Time employed in main current job	0.3	0.3	1.0	-0.6	0.6	-1.0	0.3	0.3	-0.8	0.3	0.3	-0.6	0.2	0.4	0.5	0.6
Pulse wave Arterial Stiffness index	0.3	0.4	1.3	-0.4	0.3	0.5	1.0	0.9	0.3	1.1	0.9	0.0	0.2	0.2	0.2	0.1
Pulse wave peak to peak time	0.3	0.4	1.2	0.4	-0.3	-0.4	-1.0	-1.0	-0.1	-1.1	-0.9	0.1	-0.2	-0.3	-0.3	-0.2
Emphysema/chronic bronchitis	0.3	0.4	0.9	-0.9	-0.7	0.8	-0.2	-0.1	0.2	0.4	-0.1	-0.3	-0.9	-0.9	-0.6	-0.5
Comparative height size at age 10	0.3	1.8	9.9	0.1	0.5	0.9	1.2	1.2	3.1	2.0	1.2	1.6	-1.2	-0.7	0.4	-0.1
Had major operations	0.3	0.4	1.1	0.3	-0.5	-0.3	-0.9	-0.6	-0.2	-0.9	-0.7	-1.0	0.8	0.2	-0.3	-0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.7	0.1	-0.1	-1.3	0.1	-0.0	0.2	-0.5	-0.0	0.4	1.1	0.9	0.0	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	-0.4	-0.3	0.9	0.7	0.7	0.5	1.1	0.7	0.3	-0.7	-0.1	0.1	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.5	1.6	-0.2	-0.0	1.3	0.7	0.6	-0.2	1.1	0.6	1.0	-0.7	-0.3	0.3	0.1
Fractured/broken bones in last 5 years	0.3	0.4	1.6	0.2	0.1	0.7	-0.5	-0.4	-0.2	-0.9	-0.4	-1.3	1.0	0.6	0.1	0.7
Alcohol drinker status: Previous	0.3	0.4	3.0	0.3	0.3	-1.7	0.3	0.1	-0.9	0.3	0.1	-0.0	-0.1	-0.3	-0.1	0.4
Schizophrenia vs Biploar Disorder	0.2	0.3	2.9	-0.5	0.0	1.7	0.3	0.3	0.3	0.2	0.2	-0.3	-0.5	-0.2	0.1	-0.2
Alzheimer’s Disease (in mother)	0.2	0.3	1.2	0.3	0.1	0.1	0.5	0.3	-0.4	-0.1	0.4	-0.5	1.1	0.9	0.4	0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.8	-0.1	0.1	0.2	0.6	0.4	0.3	0.9	0.5	0.1	-0.3	-0.3	0.2	-0.6
Irritable Bowel Disease (IBD)	0.2	0.5	2.2	0.8	1.5	1.2	0.2	0.3	0.3	0.1	0.4	0.4	0.6	0.4	0.9	0.6
Primary Biliary Cirrhosis	0.2	0.4	1.2	0.2	-0.2	1.0	0.4	0.5	0.1	1.0	0.4	0.2	-1.1	-0.7	0.1	-0.6
Chronotype (morning person)	0.2	0.6	2.0	0.3	-0.3	-0.3	-0.4	-0.7	1.4	-1.0	-0.6	-1.4	1.0	0.6	-0.1	0.2
Hearing difficulty/problems: Yes	0.2	0.3	1.3	0.2	-0.1	1.1	-0.3	-0.3	-0.7	-0.7	-0.3	-1.0	0.6	0.3	-0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.2	-0.2	-0.2	0.7	0.0	-0.1	-1.1	-0.1	-0.1	-0.4	-0.5	-0.6	-0.2	-1.0
Average weekly fortified wine intake	0.2	0.2	1.5	0.8	-0.1	0.1	-0.2	-0.1	-0.1	-0.3	-0.1	-1.2	0.4	0.4	-0.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.0	0.6	-0.1	0.5	-0.5	-0.4	0.5	-0.9	-0.4	-1.0	0.2	0.2	-0.4	-0.0
Supplements: Glucosamine	0.2	0.3	2.1	0.2	-0.1	1.4	0.1	-0.1	0.6	-0.3	-0.0	-0.1	0.9	0.7	-0.3	0.3
Number of incorrect matches in round	0.2	0.3	0.9	-0.4	0.5	0.3	0.7	0.8	-0.4	1.0	0.8	-0.3	-0.2	0.1	0.6	0.4
Medication: Cholesterol lowering	0.2	0.3	1.5	0.5	0.7	1.2	-0.3	-0.2	-1.2	-0.2	-0.2	0.1	-0.1	-0.3	0.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.4	0.2	0.3	-0.3	-0.9	-0.8	-0.3	-1.2	-0.8	0.4	0.3	-0.1	-0.3	-0.0
Medication: Paracetamol	0.2	0.3	1.6	0.2	-0.4	-0.2	-0.4	-0.4	1.3	-0.4	-0.4	-0.4	-0.1	-0.3	-0.8	-0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	2.0	-1.4	-0.5	-0.7	-0.5	-0.5	-0.8	-0.4	-0.4	-0.4	-0.2	-0.2	-0.5	0.1
Medication: Allopurinol	0.2	0.3	1.7	-0.6	0.6	1.1	0.2	0.1	-0.1	0.1	0.1	1.3	-0.1	-0.1	0.1	0.3
Leg pain on walking	0.2	0.3	0.9	0.3	0.9	0.6	0.6	0.7	0.1	0.6	0.7	0.2	0.3	0.4	0.5	0.7
Knee pain experienced in last month	0.2	0.4	2.7	-0.7	0.5	1.6	0.1	0.3	0.6	0.5	0.2	0.1	-0.3	-0.2	0.1	0.4
Mineral and other dietary supplements	0.2	0.3	4.1	0.0	0.3	-2.0	-0.1	0.0	-0.1	-0.1	0.0	-0.1	0.1	0.2	0.0	-0.1
Wears glasses or contact lenses	0.2	0.2	0.7	-0.1	-0.3	-0.3	0.3	0.5	-0.8	0.7	0.3	0.8	0.0	0.2	0.6	-0.2
Mother’s age at death	0.2	0.2	0.8	-0.2	-0.4	-0.6	-0.3	-0.3	-0.9	-0.2	-0.4	-0.5	-0.2	-0.3	0.0	-0.7
High cholesterol (Self-reported)	0.2	0.4	4.1	0.2	0.0	2.0	-0.3	-0.2	-0.3	-0.0	-0.2	-0.5	-0.5	-0.5	-0.0	-0.4
Medication: Paracetamol	0.2	0.3	1.5	0.4	-0.4	0.0	-0.6	-0.5	1.2	-0.6	-0.5	-0.4	-0.1	-0.2	-0.7	-0.3
Cholesterol lowering medication	0.2	0.3	1.3	1.1	0.7	0.1	0.2	0.3	-0.1	-0.1	0.2	-0.7	0.8	0.8	0.7	0.3
Blood Red Count	0.1	0.7	4.7	0.3	-0.4	0.7	-0.6	-0.5	-2.2	-0.4	-0.4	-1.5	0.5	-0.1	-0.5	-0.3
Hair Pigment	0.1	2.7	8.8	0.5	1.0	1.3	2.1	2.0	3.0	2.2	2.0	1.1	-0.1	1.0	1.4	1.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.6	-0.1	-0.6	0.7	0.2	-0.0	-0.7	-0.1	0.0	-0.0	0.0	0.0	-0.3	-0.2
Pack years adult smoking proportion	0.1	0.2	0.5	0.0	0.4	0.7	0.7	0.6	-0.3	0.5	0.6	0.0	0.5	0.4	0.4	0.2
Trunk fat percentage	0.1	0.5	1.1	1.0	1.0	1.1	0.2	0.3	0.8	-0.1	0.2	-0.2	0.8	0.8	0.8	0.7
Medication: Levothyroxine sodium	0.1	0.1	0.8	-0.4	-0.1	-0.9	-0.3	-0.2	0.1	-0.1	-0.2	0.1	-0.3	0.0	-0.0	0.4
Pain all over the body in last month	0.1	0.1	0.5	0.1	0.1	0.6	0.1	0.2	-0.3	0.3	0.1	-0.5	-0.4	-0.4	-0.0	-0.7
Fluid intelligence score	0.1	0.2	1.4	0.7	-0.3	-0.1	0.5	0.4	-1.2	0.5	0.4	0.2	-0.1	0.1	0.0	0.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.8	0.2	-0.4	0.0	0.4	0.5	-0.7	0.9	0.5	-0.2	-0.4	-0.4	0.1	-0.6
Glaucoma (self-reported)	0.1	0.1	0.6	-0.3	-0.4	-0.4	-0.3	-0.2	-0.4	-0.1	-0.2	-0.7	-0.1	0.2	-0.2	-0.3
Gout (self-reported)	0.1	0.1	0.9	-0.2	0.9	0.1	-0.1	-0.2	0.4	-0.2	-0.2	0.7	0.1	-0.0	0.0	0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.5	-0.5	-0.1	0.7	0.0	0.1	-0.4	0.6	0.1	0.5	-0.3	-0.4	-0.2	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.4	-0.2	0.4	0.6	-0.3	-0.3	-0.4	-0.6	-0.3	-0.0	0.3	0.0	0.0	0.4
Back pain experienced in last month	0.1	0.2	0.8	0.1	-0.2	0.5	0.4	0.2	0.7	0.3	0.3	0.9	-0.4	-0.2	0.0	0.1
Osteoarthritis (self-reported)	0.1	0.1	1.4	-0.0	0.4	1.2	-0.1	-0.2	0.2	-0.3	-0.1	0.3	-0.2	-0.1	-0.1	-0.1
Age started oral contraceptive pill	0.1	0.2	0.9	-0.0	-0.2	0.1	-0.2	-0.2	-0.9	-0.3	-0.3	-0.9	-0.2	-0.1	0.1	-0.3
Myopia	0.1	0.1	0.3	-0.1	0.3	0.4	-0.1	-0.2	-0.2	0.1	-0.2	0.1	-0.6	-0.4	0.2	0.1
Pack years of smoking	0.1	0.2	0.5	0.1	0.4	0.6	0.7	0.6	-0.3	0.5	0.6	0.2	0.3	0.4	0.4	0.2

Hub : Genes

EEFSEC

Models

Trait associations