Best TWAS P=8.14e-13 · Best GWAS P=1.71e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | PRKCI | 0.11 | 0.06 | lasso | 5 | 0.08 | 7.4e-07 | 6.6 | 5.7 | 1.1e-08 | -0.24 | 0.05 | 0.93 | TRUE |
| 2 | GTEx | Stomach | GPR160 | 0.20 | 0.11 | enet | 17 | 0.13 | 7.1e-07 | -6.6 | -6.6 | 3.5e-11 | 0.89 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Whole Blood | GPR160 | 0.18 | 0.16 | enet | 17 | 0.18 | 6.6e-16 | -6.4 | -6.0 | 1.8e-09 | 0.97 | 0.02 | 0.98 | TRUE |
| 4 | NTR | Blood | GPR160 | 0.02 | 0.02 | lasso | 1 | 0.02 | 2.3e-06 | -6.4 | -6.4 | 1.3e-10 | 0.96 | 0.02 | 0.98 | FALSE |
| 5 | YFS | Blood | PHC3 | 0.08 | 0.07 | bslmm | 373 | 0.07 | 4.9e-21 | -6.6 | 7.2 | 8.1e-13 | -0.97 | 0.02 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PHC3 | 0.04 | 0.01 | lasso | 5 | 0.01 | 9.7e-03 | -6.7 | 5.5 | 3.5e-08 | -0.97 | 0.01 | 0.92 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | SKIL | 0.11 | 0.02 | enet | 3 | 0.02 | 1.9e-03 | 6.6 | 6.7 | 2.5e-11 | -0.23 | 0.00 | 0.98 | TRUE |