Hub : Genes

RUVBL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0430	0.0210	7.2e-03	0.003	0.024	0.006	0.026	-0.001	1.4e-01	0.00063	5.2e-02	0.00037	4.1e-01
2	GTEx	Cells Transformed fibroblasts	0.0740	0.0280	1.7e-04	0.040	NA	0.011	NA	0.015	5.8e-04	NA	4.3e-02	NA	2.5e-02
3	GTEx	Testis	0.3060	0.0690	1.1e-10	0.299	NA	0.281	NA	0.297	8.9e-14	NA	6.8e-13	NA	1.2e-13
4	METSIM	Adipose	0.0355	0.0180	1.1e-02	0.004	0.010	0.014	0.011	0.010	8.0e-02	0.01100	2.6e-03	0.00660	1.0e-02
5	TCGA	Lung Adenocarcinoma	0.0190	0.0132	7.7e-03	0.020	0.016	0.018	NA	0.021	2.1e-03	0.00520	3.0e-03	NA	1.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.7	1.0	2.9	1.7	-0.6	-1.0	0.8	0.4
Bipolar Disorder or Schizophrenia	0.6	1.5	3.3	1.8	-1.0	-1.3	1.1	0.1
Depressed Affect (Nagel 2018)	0.7	1.5	4.3	-2.1	0.7	0.8	-0.9	1.1
Depression (Nagel 2018)	1.4	2.1	3.3	0.6	-1.4	-1.8	-1.5	-1.6
Intelligence (Savage-Jansen 2018)	1.9	5.9	10.5	-2.1	2.5	2.8	0.5	3.2
Neuroticism (Nagel 2018)	1.0	2.4	6.0	-2.4	1.0	0.8	-1.9	0.9
Schizophrenia (2018)	0.3	0.6	0.9	0.9	-0.8	-0.9	0.7	-0.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	-0.5	0.6	0.6	-0.3	-0.1
Worry (Nagel 2018)	0.7	1.6	3.7	-1.9	0.6	0.6	-1.8	0.3
Alzheimer’s Disease (in mother)	1.2	1.4	2.7	1.2	-1.0	-0.9	1.1	-1.6
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.0	-0.2	0.5	-0.6	0.6
Alzheimer’s Disease (including proxy)	0.7	1.0	1.7	1.2	-1.3	-0.7	0.0	-1.1
Crohns Disease (2017)	0.5	1.2	2.4	0.1	-1.5	-1.6	-1.1	-0.1
Irritable Bowel Disease (IBD)	0.2	0.5	1.5	-0.4	-0.4	-0.2	-0.9	1.2
Ulcerative Colitis (UC)	0.5	0.9	3.0	-0.4	0.7	0.9	-0.2	1.7
Major Depression (MDD)	2.0	2.4	5.8	-2.1	-0.5	-0.7	-2.4	1.1
Reaction Time	0.5	1.0	1.5	-1.2	1.0	0.4	-0.9	1.1
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.9	-1.2	1.2	1.3	0.8	1.7
Breast Cancer	0.4	0.9	1.6	-0.2	-1.1	-1.3	-1.2	-0.5
Ovarian Cancer	1.2	1.6	5.0	0.7	-2.2	-1.3	0.8	-0.4
Prostate Cancer	16.0	22.5	33.8	-5.2	5.8	5.8	-2.3	3.6
Age at First Birth	0.2	0.3	1.6	0.2	0.1	0.2	-0.2	-1.2
Bipolar Disorder (2011)	0.9	0.9	2.8	0.0	0.5	0.5	1.7	1.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.5	-0.6	-0.7	0.2	-0.5
Coronary Artery Disease (CAD)	4.4	5.2	8.8	-2.0	3.0	2.4	1.3	2.5
Crohns Disease (2012)	0.5	0.9	1.9	0.3	-1.3	-1.4	-0.1	-0.7
Mean Putamen Volume	1.1	1.3	2.3	1.5	-0.8	-0.8	1.2	-1.0
Fasting Glucose	2.0	2.4	8.5	0.5	-1.0	-1.0	-2.9	-1.0
HbA1C	0.2	0.2	0.3	-0.6	0.5	0.4	-0.3	0.5
HDL Cholesterol	0.5	0.9	1.8	-1.4	0.8	1.0	-0.4	0.9
LDL Cholesterol	1.0	1.6	3.7	-0.1	1.9	1.9	0.6	0.5
Lupus	0.2	0.3	0.4	-0.0	-0.6	-0.6	0.3	-0.6
Neuroticism (2016)	1.4	2.1	6.8	-2.6	0.5	0.8	-0.9	1.4
Primary Biliary Cirrhosis	0.4	0.5	0.9	0.1	0.8	0.9	0.6	0.7
Rheumatoid Arthritis	1.6	2.2	3.6	-1.5	1.5	1.7	-1.9	-0.0
Schizophrenia (2014)	0.7	1.5	2.7	1.6	-1.3	-1.4	0.8	-0.7
Triglycerides	0.2	0.4	1.0	-0.2	1.0	0.7	0.5	0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.2	1.1	-0.6	-0.3	0.1	-0.3
Ulcerative Colitis	1.5	2.2	4.9	-1.0	1.6	1.5	0.5	2.2
Blood Eosinophil Count	4.3	32.8	112.5	-6.5	2.2	2.0	-10.6	0.8
Blood Platelet Count	2.7	31.7	46.1	4.7	-6.7	-6.8	-3.8	-5.6
Blood Red Count	0.1	0.9	3.5	0.7	-0.4	-0.2	-1.9	0.7
Blood White Count	0.6	4.6	9.1	2.6	-3.0	-2.4	0.6	-1.0
Heel T-Score	0.6	4.5	6.7	-1.4	2.6	2.6	-0.7	2.6
BMI	1.3	7.5	17.3	0.5	-3.8	-4.2	-1.6	-1.6
Height	0.4	7.8	13.4	-1.6	3.6	3.7	1.8	2.5
Waist Hip Ratio (WHR)	1.3	6.1	11.4	1.0	-3.2	-3.4	-1.6	-2.3
Systolic Blood Pressure	2.7	13.4	20.9	2.7	-4.3	-4.1	-1.9	-4.6
Smoking Status	0.2	0.4	1.5	-0.5	0.1	-0.2	0.4	1.2
Allergy or Eczema	0.4	1.1	1.9	0.5	-0.8	-1.0	1.4	-1.3
Cardiovascular Disease	2.5	8.3	13.7	1.6	-3.7	-3.5	-2.9	-2.1
Hypothyroidism (self reported)	0.4	0.9	2.4	-0.8	0.8	0.7	1.6	0.2
Respiratory disease	7.8	17.5	30.9	2.7	-5.4	-5.6	1.0	-4.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.3	-0.9	0.2	0.6	-1.1	0.6
Lung FEV1/FVC ratio	22.5	114.0	201.6	-8.8	13.5	14.2	-1.2	10.4
Lung FVC	0.2	1.1	1.5	1.0	-1.0	-1.2	-0.7	-1.2
Neuroticism	1.5	3.6	8.4	-2.9	1.1	1.4	-2.1	1.4
Chronotype (morning person)	0.3	0.6	1.2	-1.1	-0.7	-0.6	-0.3	-0.9
Hair Pigment	0.0	0.9	2.8	1.2	-0.0	0.0	1.7	-0.3
Tanning	0.3	3.6	7.8	0.6	-2.5	-2.8	0.6	-1.8
Hand grip strength (left)	0.6	1.5	7.2	0.6	0.4	0.2	2.7	0.1
Number of treatments/medications taken	2.1	3.8	6.8	0.4	-2.5	-2.6	-1.8	-1.7
Average weekly spirits intake	2.3	2.9	4.8	1.4	-2.2	-2.2	-0.5	-1.6
Sensitivity / hurt feelings	1.0	1.8	5.5	-2.3	0.9	0.7	0.2	1.4
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.7	-0.1	-1.3	-1.3	-1.9	-0.6
Hearing difficulty/problems: Yes	1.2	1.8	7.4	-0.6	-0.6	-0.7	-2.7	-0.6
Relative age of first facial hair	0.8	1.7	3.1	-1.2	1.8	1.5	-0.2	1.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	4.6	-0.9	0.4	0.5	-2.1	0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	0.4	-0.2	-0.4	0.7	-0.7
Ever had hysterectomy (womb removed)	1.7	1.9	4.3	-2.1	1.0	1.0	-1.5	0.9
Systolic blood pressure, automated reading	1.6	4.8	7.2	1.4	-2.5	-2.7	-1.7	-2.5
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.3	0.4	-1.5	-1.2	-1.3	-0.2
Angina	0.8	1.1	2.4	-0.2	-1.1	-1.2	-1.6	-0.6
Medication for hormone replacement therapy	2.9	3.3	5.6	-1.4	1.5	1.5	2.1	2.4
Vitamin and mineral supplements	0.9	1.2	3.5	1.9	-0.7	-0.2	-0.7	-1.2
Supplements: Zinc	0.4	0.5	0.8	-0.4	0.6	0.7	0.9	0.7
Medication: Co-codamol	4.7	5.4	8.2	1.6	-2.7	-2.4	-1.9	-2.9
Medication: Metformin	2.3	3.2	14.1	-0.8	0.3	0.7	-3.8	1.0
Diabetes (father)	0.4	0.5	2.1	-0.3	-0.4	-0.1	-1.5	0.2
Diabetes (mother)	1.4	1.7	2.8	0.1	-1.7	-1.6	-1.7	-0.7
Severe depression (siblings)	0.6	0.7	1.1	-1.0	1.0	0.8	-0.7	0.5
Pack years adult smoking proportion	0.3	0.5	1.6	-0.0	-0.6	-0.5	-1.3	0.0
Impedance of leg (right)	0.8	3.6	8.8	-0.1	3.0	3.0	-0.1	0.8
Leg fat-free mass (left)	0.2	1.1	2.2	-0.7	-1.5	-1.5	0.8	0.1
Trunk fat percentage	0.1	0.5	1.2	-0.1	-0.7	-0.8	-1.1	0.3
Hand grip strength (right)	0.8	2.2	9.7	0.1	0.6	0.6	3.1	0.6
Townsend deprivation index at recruitment	0.5	0.7	2.9	0.1	-0.8	-0.3	-1.7	0.3
Current tobacco smoking	0.3	0.5	1.8	-0.2	0.5	0.4	-0.6	1.3
Average weekly fortified wine intake	0.2	0.2	0.4	0.6	-0.2	-0.4	0.7	-0.1
Maternal smoking around birth	0.3	0.5	1.3	-0.2	0.6	0.7	1.1	0.5
Fed-up feelings	1.2	2.2	5.7	-2.4	0.8	0.7	-1.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	-0.6	-0.1	-0.2	-0.7	-0.4
Relative age voice broke	0.7	1.1	2.7	0.7	-0.9	-1.7	0.1	-1.2
Taking other prescription medications	2.8	4.3	7.0	1.5	-2.0	-2.1	-2.6	-2.0
Age when periods started (menarche)	2.4	5.7	9.9	-2.5	2.9	3.1	-0.6	1.9
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.9	-1.2	1.1	1.7	-0.0	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.0	-1.1	1.3	1.1	0.4	1.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.1	-0.3	-0.5	-0.0	-0.5
Qualifications: CSEs or equivalent	0.6	0.8	1.8	-0.0	-0.8	-0.7	1.4	-1.0
Serious illness, injury or assault to yourself	0.9	1.1	3.1	-1.8	0.4	0.7	-0.2	1.4
High blood pressure	6.2	17.4	28.2	2.5	-5.3	-5.0	-3.5	-3.9
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.4	-0.0	-0.7	-1.0	1.2	-1.1
Multivitamins +/- minerals	0.2	0.3	1.1	-1.1	-0.1	-0.3	0.3	-0.2
Stomach or abdominal pain in last month	0.9	1.1	1.6	1.0	-1.0	-0.9	-1.3	-1.1
Supplements: Glucosamine	0.2	0.3	0.5	-0.3	-0.5	-0.5	0.4	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.4	0.6	0.5	-0.2	0.3
Medication: Atenolol	1.9	2.4	5.2	0.4	-1.9	-2.3	-0.9	-1.5
Medication: Levothyroxine sodium	0.2	0.3	0.6	-0.8	0.2	0.4	0.8	0.4
Sitting height	0.4	3.0	5.0	-2.2	1.6	1.7	1.0	1.9
Chronic bronchitis/emphysema (father)	5.0	5.9	9.5	1.2	-2.5	-2.8	-3.1	-2.1
High blood pressure (mother)	2.4	3.4	7.0	1.4	-2.6	-2.4	-0.3	-1.6
Body mass index (BMI)	1.7	7.4	16.7	1.0	-3.8	-4.1	-1.4	-1.7
Impedance of leg (left)	0.8	3.9	9.2	-0.4	3.0	2.9	-0.1	1.1
Leg predicted mass (left)	0.2	1.0	2.0	-0.7	-1.4	-1.4	0.7	0.2
Trunk fat mass	0.2	0.9	1.8	-0.1	-1.3	-1.3	-0.9	0.2
Waist circumference	1.9	6.8	14.2	0.9	-3.6	-3.8	-1.9	-1.7
Number of incorrect matches in round	0.0	0.1	0.2	0.4	0.3	-0.1	0.1	-0.3
Past tobacco smoking	0.2	0.3	0.8	-0.3	0.9	0.7	-0.3	-0.3
Alcohol usually taken with meals	2.2	3.5	6.2	-1.3	2.5	2.3	1.3	1.6
Nervous feelings	0.8	1.4	3.6	-1.9	0.5	0.2	-1.8	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	5.5	-2.4	0.8	0.8	-2.0	1.4
Hearing difficulty/problems with background noise	1.3	2.0	8.2	-0.7	-0.8	-0.8	-2.9	-0.0
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	0.1	0.4	0.5	-0.7	-0.0
Had menopause	1.1	1.4	2.9	0.8	-0.6	-1.2	1.2	-1.7
Had other major operations	2.7	3.3	7.0	1.1	-2.6	-2.6	0.4	-1.1
Forced vital capacity (FVC)	0.5	2.0	3.5	-0.5	1.6	1.9	1.0	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.2	-0.5	1.0	1.0	0.8	1.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.1	-1.1	0.1	-0.2	0.6	0.3
Qualifications: None of the above	2.5	5.3	8.6	1.8	-2.4	-2.9	-1.2	-2.7
Financial difficulties in last 2 years	0.1	0.2	0.5	-0.1	0.7	-0.2	0.1	0.6
Mouth/teeth dental problems	2.1	3.2	5.8	-0.0	2.1	2.4	2.2	0.9
Heart attack	1.8	2.3	4.0	1.1	-1.8	-2.0	-1.7	-0.5
Allergy	2.6	6.0	12.8	-1.4	3.0	3.6	-0.5	2.5
Pain all over the body in last month	0.6	0.7	1.4	-0.5	0.3	0.6	-1.1	1.2
Diabetes (self-reported)	0.4	0.5	2.5	0.2	-0.2	0.3	-1.6	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	1.0	0.2	0.2	-0.2	0.1	-1.0
Medication: Ramipril	2.5	3.3	6.7	0.7	-2.1	-1.8	-2.6	-1.3
Medication: Simvastatin	0.5	0.7	1.5	-1.2	0.5	0.4	-1.0	0.8
Fluid intelligence score	0.0	0.1	0.2	0.5	-0.2	-0.1	0.2	0.3
Illnesses of siblings	3.7	5.2	10.6	-1.3	2.2	3.3	1.3	2.7
Neuroticism score	2.7	5.6	12.7	-3.6	1.4	1.4	-2.4	2.3
Weight	0.4	1.9	5.0	-0.3	-2.1	-2.2	-0.3	-0.2
Impedance of arm (right)	1.5	7.0	17.3	-0.5	3.8	4.2	0.5	1.6
Arm fat percentage (right)	1.2	4.8	9.7	1.3	-3.0	-3.1	-1.5	-1.3
Trunk fat-free mass	0.2	1.1	2.2	-0.5	-1.4	-1.5	1.1	0.1
Hip circumference	0.1	0.6	1.8	0.0	-1.1	-1.3	-0.1	-0.0
Time employed in main current job	0.1	0.2	0.6	-0.7	-0.3	-0.2	0.3	0.0
Alcohol intake versus 10 years previously	0.3	0.4	1.0	-0.6	-1.0	-0.5	0.0	0.5
Father’s age at death	1.7	2.3	5.6	1.3	-1.8	-2.4	-0.1	-1.0
Worrier / anxious feelings	0.3	0.5	1.8	-1.4	-0.2	0.1	-0.7	-0.2
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	8.5	-2.9	1.0	0.7	-0.9	1.8
Falls in the last year	0.9	1.2	2.5	-1.1	0.8	1.0	-0.9	1.6
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.1	0.2	0.2	-0.2	0.3
Number of live births	1.4	2.0	3.1	1.0	-1.6	-1.8	1.5	-1.2
Forced expiratory volume in 1-second (FEV1)	3.7	12.6	22.8	-2.3	4.4	4.8	0.3	3.9
Pulse rate	1.4	2.3	3.3	-1.1	1.6	1.7	-1.2	1.8
Happiness	3.5	4.2	11.6	-1.1	-2.2	-1.7	-3.4	0.4
Noisy workplace	0.5	0.6	2.3	0.2	-0.4	-0.4	-0.4	-1.5
Qualifications: A levels/AS levels or equivalent	1.1	2.4	6.0	-0.7	2.3	2.5	0.7	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	0.1	1.1	0.6	1.3	0.8
Mouth/teeth dental problems: Dentures	0.8	1.4	3.3	0.6	-1.6	-1.8	-0.8	-0.4
Asthma	6.2	12.3	24.0	1.9	-4.7	-4.9	0.1	-3.4
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	3.4	-1.0	-1.3	-1.3	-1.8	-0.4
Medication: Cholesterol lowering	0.4	0.7	2.3	-0.7	0.0	-0.1	-1.5	0.8
Depression (self-reported)	0.6	0.7	2.2	-0.8	0.1	0.3	-1.5	0.6
Medication: Lansoprazole	2.5	2.8	5.0	1.8	-1.0	-1.2	-1.9	-2.2
Prospective memory result	1.1	1.3	3.6	1.0	-0.6	-1.3	-0.2	-1.9
Lung cancer (father)	1.1	1.3	2.9	-0.6	1.5	1.7	-0.5	0.9
Illnesses of mother	1.7	2.1	4.2	-0.8	2.1	1.5	1.5	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	4.0	12.9	25.2	-2.3	4.5	5.0	0.6	3.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.2	-0.1	-0.4	-0.3	-0.3
Impedance of arm (left)	1.8	8.4	20.4	-0.5	4.0	4.5	1.0	2.0
Arm fat mass (right)	1.0	3.9	9.1	1.0	-2.8	-3.0	-0.8	-1.1
Trunk predicted mass	0.2	1.1	2.2	-0.4	-1.4	-1.5	1.0	0.0
Standing height	0.8	7.5	11.4	-2.1	3.2	3.4	2.2	2.6
Length of working week for main job	0.5	0.5	1.3	0.5	0.2	0.5	0.8	1.1
Exposure to tobacco smoke at home	1.2	1.3	2.6	0.6	-1.3	-1.3	1.6	-0.7
Breastfed as a baby	0.6	0.8	2.5	-0.5	0.7	0.8	-1.6	-0.1
Tense / ‘highly strung’	2.3	3.9	6.2	-2.5	2.1	1.7	-0.7	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	4.2	-2.1	-0.1	-0.1	-1.3	0.7
Hair/balding pattern: Pattern 4	0.4	1.1	2.0	0.4	-1.4	-1.2	-1.0	-1.0
Birth weight of first child	0.9	1.7	2.8	-1.7	1.5	1.5	1.0	-0.2
Peak expiratory flow (PEF)	1.0	2.3	4.5	1.1	1.8	2.1	0.5	1.5
Pulse wave reflection index	0.4	0.5	1.5	-0.0	-0.7	-1.2	0.2	-0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	1.0	-0.0	-0.2	0.3	0.9
Loud music exposure frequency	0.9	1.0	3.5	0.7	-0.6	-0.4	1.9	-0.6
Qualifications: O levels/GCSEs or equivalent	3.3	5.2	10.6	-0.3	2.9	3.3	1.3	2.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	-0.5	-0.1	0.3	-0.8	-0.1
Blood clot in the leg (DVT)	2.0	2.6	7.3	1.2	-1.8	-2.7	0.3	-0.9
Medication: Paracetamol	0.2	0.3	0.7	-0.7	0.3	0.3	-0.2	0.9
Headache pain in last month	0.5	0.8	1.9	-1.4	0.6	1.0	-0.9	0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.1	0.4	0.9	1.0	1.8	-0.0
Glaucoma (self-reported)	0.1	0.1	0.4	-0.1	0.0	0.2	-0.4	0.6
Gout (self-reported)	0.1	0.2	0.5	-0.7	-0.1	-0.1	0.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.5	-0.9	0.4	0.3	1.2	0.4
Medication: Amlodipine	2.3	3.2	7.6	1.7	-1.6	-1.1	-2.8	-1.5
Medication: Ventolin 100micrograms inhaler	4.5	5.7	10.1	1.8	-2.5	-3.2	0.8	-2.9
Birth weight	0.3	0.7	2.4	0.1	-0.6	-0.7	1.5	-0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	-0.7	0.5	0.8	-1.0	1.1
High blood pressure (siblings)	4.0	5.8	10.3	1.6	-2.8	-3.2	-0.8	-2.8
Forced vital capacity (FVC), Best measure	0.5	2.0	3.9	-0.5	1.5	2.0	1.2	1.4
Body fat percentage	0.4	1.5	3.1	0.4	-1.6	-1.7	-1.4	-0.3
Leg fat percentage (right)	1.2	4.3	8.1	1.1	-2.5	-2.9	-2.0	-1.3
Arm fat-free mass (right)	0.2	1.2	2.8	-0.8	-1.5	-1.7	0.6	0.3
Exposure to tobacco smoke outside home	0.6	0.8	2.6	-0.1	-1.6	-1.1	0.0	-0.6
Comparative body size at age 10	0.7	1.8	3.0	1.7	-1.7	-1.6	-0.3	-0.7
Number of full brothers	2.4	3.0	7.4	0.5	-2.2	-2.7	0.8	-1.4
Worry too long after embarrassment	1.0	1.7	4.5	-2.1	1.0	0.9	-1.5	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.1	-1.3	0.4	0.1	-1.0	1.8
Wheeze or whistling in the chest in last year	3.3	5.8	10.5	1.3	-3.2	-3.2	-0.6	-2.5
Number of children fathered	1.0	1.1	1.9	1.0	1.2	1.0	1.4	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.0	-0.4	0.8	1.0	-0.5	0.6
Age at first live birth	0.4	0.7	2.1	-1.4	0.7	0.8	0.0	0.1
Pulse wave peak to peak time	0.1	0.1	0.2	0.1	0.2	0.5	0.5	0.4
Health satisfaction	0.9	1.2	2.7	-0.1	-1.1	-1.6	-1.1	-0.9
Shortness of breath walking on level ground	0.3	0.3	0.7	-0.4	-0.5	-0.7	-0.8	0.4
Qualifications: College or University degree	2.5	8.0	10.9	-2.8	2.8	3.2	1.8	3.3
Eye problems/disorders: None of the above	0.8	1.0	2.6	-0.1	1.4	1.6	0.2	-0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.7	-0.2	0.2	0.6	0.7	1.3
Emphysema/chronic bronchitis	0.6	0.7	1.1	-0.7	1.1	0.7	0.5	1.0
Medication for pain relief, constipation, heartburn	2.1	3.5	6.3	-1.0	2.3	2.5	1.8	1.3
Neck or shoulder pain in last month	3.0	4.2	9.3	-2.3	1.4	1.3	-1.7	3.0
Medication: Blood pressure	1.7	3.0	5.7	0.8	-1.8	-2.0	-2.4	-1.2
Angina (self-reported)	0.8	1.1	3.0	-0.4	-1.0	-1.0	-1.7	-0.4
Migraine (self-reported)	0.5	0.7	1.0	1.0	-0.9	-0.8	-0.2	-0.9
Medication: Ibuprofen	1.8	2.1	3.3	-0.8	-1.7	-1.8	-1.7	-0.9
Medication: Allopurinol	0.2	0.3	1.4	0.3	0.1	0.2	1.2	0.2
Medication: Omeprazole	0.4	0.4	1.0	1.0	-0.3	-0.9	0.5	-0.3
Medication: Seretide 50 evohaler	0.7	0.8	1.9	0.7	-0.8	-0.9	0.3	-1.4
Mean time to correctly identify matches	0.4	0.7	1.7	-0.5	1.0	0.4	-1.3	0.8
Heart disease (mother)	2.7	3.3	6.0	1.5	-1.8	-1.8	-2.5	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.5	0.7	0.1	-0.0	0.2	0.0
Whole body fat mass	0.5	2.1	4.8	0.5	-2.0	-2.2	-1.1	-0.4
Leg fat mass (right)	1.0	3.9	8.7	0.7	-2.7	-3.0	-1.5	-0.9
Arm predicted mass (right)	0.3	1.4	3.3	-0.6	-1.7	-1.8	0.6	-0.0
Pulse rate, automated reading	1.2	4.0	5.3	-1.5	2.2	2.3	-1.9	2.0
Alcohol intake frequency.	0.2	0.6	1.6	0.1	-1.0	-1.3	0.2	-0.3
Comparative height size at age 10	0.2	1.3	3.0	-1.7	0.9	0.7	1.0	1.1
Number of full sisters	1.3	1.6	2.8	-1.2	-1.4	-1.4	-1.7	-0.5
Suffer from ‘nerves’	0.7	1.1	3.6	-0.8	-0.9	-0.4	-1.9	-0.4
Overall health rating	2.1	4.4	10.2	-0.1	-2.4	-2.4	-3.2	-0.5
Chest pain or discomfort	0.5	0.7	2.5	0.8	-0.4	-0.2	-1.6	-0.3
Had major operations	0.3	0.3	0.9	0.4	-0.7	-0.2	-1.0	-0.3
Age at last live birth	0.4	0.5	1.4	-1.2	0.8	0.6	-0.6	0.0
Family relationship satisfaction	1.5	1.9	3.2	0.7	-1.7	-1.7	-1.8	-0.0
Leg pain on walking	0.2	0.3	0.5	-0.6	-0.3	-0.7	-0.5	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.6	1.0	-0.5	-0.5	-0.9	-1.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.7	0.7	-0.9	-1.0	-0.2	-1.6
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	4.6	0.4	-0.9	-0.6	-0.4	-2.1
Medication: Aspirin	1.7	2.3	4.4	1.0	-1.5	-1.6	-2.1	-1.1
Supplements: Vitamin C	1.6	1.9	3.5	-1.6	1.2	1.3	0.6	1.9
Knee pain experienced in last month	0.9	1.4	2.8	-1.7	-0.1	-0.0	-1.6	1.4
Hypertension (Self-reported)	5.8	16.1	24.6	2.4	-5.0	-4.8	-3.7	-3.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.3	2.1	-0.5	-0.8	0.1	-1.0
Illnesses of father: Heart disease	0.4	0.6	1.9	0.7	-1.4	-0.9	-0.1	0.1
Illnesses of siblings: Diabetes	0.6	0.7	1.7	-0.4	-0.7	-1.3	-1.0	-0.4
Smoking status: Previous	0.1	0.2	0.4	-0.1	-0.6	-0.5	0.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	3.3	-1.7	1.7	1.8	0.5	1.7
Whole body fat-free mass	0.2	1.2	2.5	-0.7	-1.5	-1.6	1.0	0.1
Leg fat-free mass (right)	0.2	1.1	1.8	-0.9	-1.3	-1.3	1.0	0.5
Arm fat percentage (left)	1.0	4.1	8.4	1.3	-2.8	-2.9	-1.3	-1.0
Average weekly red wine intake	1.8	2.6	4.1	-1.5	1.6	1.8	2.0	1.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.8	1.9	0.5	0.2	0.4	-1.0
Mood swings	0.7	1.2	2.3	-1.5	0.8	1.1	-1.0	0.9
Loneliness, isolation	0.6	0.8	1.7	-0.8	-1.2	-1.3	0.3	0.3
Long-standing illness, disability or infirmity	1.0	1.6	2.8	-0.2	-1.7	-1.5	-1.6	0.5
Ever had bowel cancer screening	2.7	3.2	5.3	1.7	-1.8	-2.3	0.8	-2.0
Diabetes diagnosed by doctor	0.6	0.9	4.0	-0.1	0.1	0.8	-2.0	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	4.6	-1.0	0.1	0.3	0.9	2.2
Friendships satisfaction	2.6	3.3	6.8	0.5	-2.3	-2.0	-2.6	-0.5
Qualifications: nursing, teaching	1.5	2.4	5.1	-0.6	1.7	2.3	1.0	1.6
Commuting to job workplace: Walk	0.0	0.1	0.1	0.2	-0.3	-0.3	0.2	-0.0
Eye problems/disorders: Cataract	0.4	0.5	1.1	0.2	-0.6	-1.0	1.0	0.1
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	5.1	0.3	-1.8	-2.3	-2.0	-1.3
Medication for cholesterol	1.1	1.7	3.9	-0.7	2.0	1.8	-0.4	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	1.1	0.0	-0.6	-0.6	0.7
Back pain experienced in last month	0.1	0.1	0.3	-0.3	0.1	0.5	-0.2	-0.2
Mineral and other dietary supplements	0.1	0.1	0.3	0.3	-0.1	-0.1	-0.5	-0.4
Breast cancer (self-reported)	0.3	0.4	0.7	0.3	0.7	0.7	0.8	0.0
Asthma (self-reported)	6.7	13.4	26.3	2.0	-5.0	-5.1	0.4	-3.5
Osteoporosis (self-reported)	0.8	0.9	3.5	-0.1	0.9	1.9	0.4	-0.6
Osteoarthritis (self-reported)	0.1	0.1	0.3	0.2	0.1	0.1	-0.6	0.1
Medication: Aspirin	1.6	2.1	3.6	0.7	-1.6	-1.6	-1.9	-1.1
Medication: Gliclazide	1.2	1.3	4.9	0.4	0.5	1.2	-2.2	0.3
Illnesses of father: None of the above (group 1)	4.9	6.1	11.6	-0.9	3.4	3.0	2.8	1.1
Smoking status: Current	0.5	0.7	2.2	-0.5	0.6	0.6	-0.8	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.8	10.6	-0.4	3.1	3.3	0.9	1.8
Whole body water mass	0.2	1.2	2.6	-0.5	-1.5	-1.6	1.0	0.2
Leg predicted mass (right)	0.2	1.1	1.8	-0.9	-1.4	-1.4	0.9	0.5
Arm fat mass (left)	1.1	4.4	10.0	1.1	-2.9	-3.2	-0.9	-1.1
Number of self-reported non-cancer illnesses	5.9	10.2	19.5	1.8	-4.2	-4.4	-1.4	-3.0
Average weekly champagne plus white wine intake	2.2	3.0	7.0	-0.5	1.9	1.8	-1.0	2.7
Miserableness	3.6	6.2	12.9	-3.6	2.0	2.2	-0.9	2.9
Guilty feelings	0.5	0.8	2.5	-1.6	0.2	0.5	-0.8	0.7
Wears glasses or contact lenses	0.3	0.3	0.8	0.9	-0.6	-0.1	-0.7	-0.1
Ever taken oral contraceptive pill	0.5	0.6	2.3	-0.5	0.2	0.3	0.4	1.5
Hearing aid user	0.3	0.3	0.8	-0.4	0.6	0.5	0.2	0.9
Mother’s age at death	0.5	0.6	2.5	1.6	0.0	0.4	0.6	-0.4
Financial situation satisfaction	3.0	3.8	5.7	1.6	-2.4	-2.2	-1.3	-1.9
Tinnitus: Yes, now most or all of the time	1.7	2.0	4.7	0.9	-1.3	-1.4	0.9	-2.2
Commuting to job workplace: Public transport	0.5	0.6	1.3	-0.6	0.8	0.6	0.3	1.1
Eye problems/disorders: Glaucoma	1.4	1.6	3.1	1.8	-1.4	-1.5	-0.4	-0.7
Medication: Blood pressure	4.6	8.8	15.3	2.3	-3.9	-3.4	-1.4	-3.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.2	-0.0	-1.3	-1.5	-0.4	0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.7	-0.2	0.4	0.4	0.6	1.3
High cholesterol (Self-reported)	0.2	0.3	1.3	0.0	0.4	0.2	-1.1	0.3
Medication: Bendroflumethiazide	5.4	8.3	10.8	3.2	-3.1	-3.3	-0.7	-3.2
Medication: Paracetamol	0.3	0.4	1.0	-0.9	0.3	0.1	-1.0	0.6
Medication: Lisinopril	1.8	2.4	4.2	0.9	-1.8	-1.8	-0.8	-2.0
Medication: Atorvastatin	0.6	0.7	1.8	0.7	-0.0	-0.0	-1.3	-1.1
Illnesses of father: High blood pressure	0.6	0.8	1.8	-0.0	-1.3	-1.4	-0.6	-0.4
Alcohol drinker status: Never	2.1	2.5	7.5	1.0	-1.5	-1.3	0.2	-2.7
Ever smoked	0.5	0.9	2.5	0.3	-1.6	-1.2	-0.4	0.0
Basal metabolic rate	0.3	1.4	3.2	-0.6	-1.7	-1.8	0.7	0.1
Leg fat percentage (left)	1.2	4.2	9.0	0.8	-2.6	-3.0	-1.8	-1.2
Arm fat-free mass (left)	0.4	2.0	5.3	-0.2	-2.0	-2.3	0.4	-0.5
Number of operations (self-reported)	2.2	3.3	5.7	1.7	-2.4	-2.2	-1.0	-1.4
Average weekly beer plus cider intake	2.4	3.5	7.0	1.5	-2.6	-2.4	-0.2	-1.5
Irritability	1.9	3.1	6.1	-1.6	0.7	0.9	-2.3	2.5
Risk taking	0.6	0.8	1.9	0.7	-1.4	-1.3	-0.3	-0.3
Ever had prostate specific antigen (PSA) test	1.9	2.2	4.7	-2.2	1.3	1.6	-1.3	0.7
Fractured/broken bones in last 5 years	0.4	0.6	1.1	0.3	-0.9	-1.0	0.1	-1.0
Age started oral contraceptive pill	0.3	0.3	1.1	0.6	-0.1	0.2	-1.1	-0.5
Diastolic blood pressure, automated reading	0.2	0.6	2.2	0.8	-0.2	-0.5	-1.5	-0.3
Ever depressed for a whole week	1.1	1.4	2.4	-1.1	-1.3	-1.6	-1.1	-0.7
Unable to work because of sickness or disability	0.4	0.5	1.1	0.3	-1.0	-0.7	-0.7	-0.4
Commuting to job workplace: Cycle	2.1	2.6	4.7	1.7	-1.1	-1.1	-1.7	-2.2
Myopia	0.8	1.2	2.3	-1.5	0.3	0.8	0.8	1.4
Vascular/heart problems diagnosed by doctor	5.5	15.1	23.4	-2.3	4.8	4.5	3.3	3.9
Cholesterol lowering medication	0.7	1.1	2.6	1.6	-0.9	-0.7	-1.1	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	0.6	-0.3	-0.8	0.5	0.2
Pain experienced in last month	1.3	2.2	3.9	2.0	-1.2	-1.3	0.7	-1.9
Supplements: Calcium	0.5	0.6	1.5	0.0	-0.8	-0.8	-0.2	-1.2
Basal cell carcinoma (self-reported)	1.7	2.0	2.9	-1.1	1.6	1.7	0.9	1.6
Heart attack/myocardial infarction (self-reported)	1.7	2.2	4.3	0.9	-1.8	-2.1	-1.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	6.8	1.2	-1.7	-2.6	0.2	-0.9
Heart disease (siblings)	1.8	2.2	3.6	-0.3	-1.1	-1.8	-1.9	-1.7
Alcohol drinker status: Previous	1.0	1.2	5.4	-0.1	0.3	0.3	2.3	0.6
Pack years of smoking	0.3	0.4	1.6	-0.0	-0.5	-0.6	-1.3	-0.1
Impedance of whole body	1.5	7.7	18.3	-0.7	4.0	4.3	0.4	1.9
Leg fat mass (left)	1.1	4.1	9.9	0.6	-2.8	-3.1	-1.3	-0.9
Arm predicted mass (left)	0.4	2.1	5.7	-0.4	-2.1	-2.4	0.5	-0.5