Best TWAS P=7.11e-17 · Best GWAS P=1.26e-22 conditioned to 2.66e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | HIBADH | 0.22 | 0.07 | enet | 16 | 0.15 | 1.3e-08 | 5.4 | -6.5 | 7.2e-11 | 0.41 | 0.97 | 0.00 | FALSE |
| 2 | GTEx | Artery Tibial | HIBADH | 0.17 | 0.09 | enet | 18 | 0.11 | 9.2e-09 | -7.4 | -7.3 | 2.5e-13 | 0.48 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Brain Cerebellum | HIBADH | 0.19 | 0.17 | lasso | 3 | 0.14 | 5.2e-05 | 5.4 | -5.1 | 3.1e-07 | 0.30 | 0.34 | 0.05 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | SKAP2 | 0.17 | 0.02 | enet | 22 | 0.05 | 8.0e-05 | 1.4 | -5.3 | 1.1e-07 | 0.08 | 0.20 | 0.05 | TRUE |
| 5 | GTEx | Testis | TAX1BP1 | 0.31 | 0.28 | enet | 15 | 0.28 | 9.0e-13 | 3.7 | 5.4 | 6.5e-08 | -0.38 | 1.00 | 0.00 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | TAX1BP1 | 0.10 | 0.03 | bslmm | 515 | 0.07 | 8.3e-09 | -4.0 | 8.3 | 7.1e-17 | -0.49 | 0.92 | 0.07 | TRUE |
| 7 | YFS | Blood | TAX1BP1 | 0.02 | 0.01 | bslmm | 522 | 0.02 | 1.7e-06 | -8.9 | 8.0 | 1.3e-15 | -0.42 | 0.53 | 0.10 | TRUE |