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chr7:97,038,925-98,725,348

Best TWAS P=2.55e-15 · Best GWAS P=3.69e-18 conditioned to 0.118

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
61	GTEx	Thyroid	LMTK2	0.08	0.06	lasso	7	0.04	6.3e-04	-7.3	7.9	2.6e-15	0.90	0.02	0.98	TRUE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	BHLHA15	0.05	0.04	blup	44	0.03	7.8e-05	8.6	7.5	7.2e-14	0.74	0.00	0.99	TRUE
32	GTEx	Esophagus Mucosa	LMTK2	0.14	0.05	lasso	7	0.05	3.5e-04	8.5	7.7	2.0e-14	0.88	0.02	0.97	FALSE
51	GTEx	Skin Sun Exposed Lower leg	TECPR1	0.19	0.09	enet	23	0.19	2.4e-15	4.6	7.6	3.8e-14	0.77	0.02	0.98	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	TECPR1	0.13	0.01	lasso	6	0.03	1.0e-02	8.5	7.5	9.3e-14	0.85	0.02	0.96	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	TECPR1	0.23	0.05	lasso	6	0.04	1.9e-02	6.8	-7.3	2.5e-13	-0.79	0.02	0.92	FALSE
72	The Cancer Genome Atlas	Lung Adenocarcinoma	TECPR1	0.04	0.03	lasso	3	0.02	1.0e-03	-6.0	7.2	7.7e-13	0.78	0.05	0.91	FALSE
19	GTEx	Brain Frontal Cortex BA9	RP11-307C18.1	0.20	0.02	lasso	7	0.02	1.2e-01	8.1	-7.2	8.0e-13	-0.74	0.05	0.59	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	BHLHA15	0.05	0.01	lasso	8	0.03	1.0e-03	8.6	7.0	2.3e-12	0.77	0.01	0.93	FALSE
13	GTEx	Artery Tibial	RP11-307C18.1	0.19	0.11	lasso	7	0.24	2.5e-18	5.9	-6.9	5.1e-12	-0.71	0.99	0.01	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	TECPR1	0.02	0.01	lasso	3	0.01	2.5e-02	-6.1	6.7	1.9e-11	0.72	0.03	0.69	FALSE
64	GTEx	Vagina	RP11-307C18.1	0.45	0.27	lasso	8	0.21	1.3e-05	4.9	-6.6	3.1e-11	-0.54	0.15	0.46	FALSE
12	GTEx	Artery Tibial	RP4-607J23.2	0.29	0.19	lasso	6	0.30	3.5e-24	5.0	-6.6	3.5e-11	-0.66	1.00	0.00	FALSE
50	GTEx	Skin Sun Exposed Lower leg	BAIAP2L1	0.11	0.06	lasso	4	0.10	1.0e-08	-6.2	6.6	3.7e-11	0.62	0.99	0.01	FALSE
36	GTEx	Heart Atrial Appendage	RP11-307C18.1	0.20	0.07	enet	8	0.04	5.3e-03	5.0	-6.6	4.9e-11	-0.65	0.33	0.51	FALSE
55	GTEx	Spleen	RP4-607J23.2	0.33	0.22	lasso	4	0.34	1.6e-09	4.6	-6.6	5.3e-11	-0.69	0.46	0.41	FALSE
70	The Cancer Genome Atlas	Breast Invasive Carcinoma	BHLHA15	0.02	0.01	blup	44	0.01	4.1e-04	4.4	6.5	6.8e-11	0.67	0.01	0.59	FALSE
37	GTEx	Heart Left Ventricle	RP4-607J23.2	0.14	0.05	lasso	4	0.08	4.7e-05	5.4	-6.5	8.3e-11	-0.69	0.46	0.36	FALSE
41	GTEx	Muscle Skeletal	RP11-307C18.1	0.09	0.09	lasso	10	0.11	3.2e-11	5.9	-6.4	1.2e-10	-0.67	1.00	0.00	FALSE
60	GTEx	Thyroid	BRI3	0.11	0.05	lasso	7	0.06	2.3e-05	5.0	6.4	1.5e-10	0.58	0.20	0.72	FALSE
7	GTEx	Artery Aorta	RP11-307C18.1	0.27	0.30	lasso	6	0.31	7.9e-18	5.9	-6.4	2.0e-10	-0.70	1.00	0.00	FALSE
39	GTEx	Lung	RP11-307C18.1	0.11	0.16	enet	9	0.17	4.5e-13	5.9	-6.3	2.4e-10	-0.67	1.00	0.00	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	RP11-307C18.1	0.23	0.16	enet	10	0.24	2.1e-13	5.9	-6.3	2.8e-10	-0.63	1.00	0.00	FALSE
8	GTEx	Artery Coronary	RP4-607J23.2	0.29	0.36	enet	12	0.36	6.9e-13	5.0	-6.3	3.5e-10	-0.61	1.00	0.00	FALSE
24	GTEx	Breast Mammary Tissue (Female)	RP4-607J23.2	0.26	0.12	enet	11	0.25	4.7e-08	5.9	-6.3	3.5e-10	-0.66	0.72	0.20	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	BAIAP2L1	0.04	0.04	enet	12	0.04	1.8e-05	-6.1	6.3	3.7e-10	0.70	0.37	0.62	FALSE
2	GTEx	Adipose Subcutaneous	RP11-307C18.1	0.22	0.16	lasso	7	0.29	5.3e-24	4.4	-6.3	3.8e-10	-0.61	1.00	0.00	FALSE
65	METSIM	Adipose	BRI3	0.07	0.07	enet	44	0.08	1.1e-11	4.9	6.2	4.2e-10	0.55	0.99	0.01	FALSE
43	GTEx	Nerve Tibial	RP11-307C18.1	0.25	0.22	lasso	7	0.24	6.4e-17	5.9	-6.2	4.4e-10	-0.65	1.00	0.00	FALSE
6	GTEx	Artery Aorta	RP4-607J23.2	0.38	0.32	lasso	5	0.38	3.7e-22	5.9	-6.2	4.5e-10	-0.63	1.00	0.00	FALSE
54	GTEx	Small Intestine Terminal Ileum	RP4-607J23.2	0.37	0.27	lasso	6	0.24	5.0e-06	5.9	-6.2	4.5e-10	-0.73	0.20	0.21	FALSE
9	GTEx	Artery Coronary	RP11-307C18.1	0.30	0.20	enet	11	0.30	6.6e-11	5.3	-6.2	4.8e-10	-0.65	0.99	0.01	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RP11-307C18.1	0.27	0.15	lasso	12	0.13	2.7e-04	5.9	-6.2	5.1e-10	-0.71	0.16	0.67	FALSE
5	GTEx	Adrenal Gland	RP4-607J23.2	0.18	0.16	lasso	5	0.15	5.7e-06	5.9	-6.2	5.6e-10	-0.66	0.56	0.06	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	BAIAP2L1	0.10	0.12	lasso	3	0.12	2.3e-07	-6.1	6.2	6.5e-10	0.64	0.94	0.02	FALSE
3	GTEx	Adipose Visceral Omentum	RP4-607J23.2	0.35	0.18	enet	28	0.38	5.3e-21	5.0	-6.1	8.9e-10	-0.63	1.00	0.00	FALSE
23	GTEx	Breast Mammary Tissue	RP11-307C18.1	0.23	0.16	lasso	3	0.23	4.5e-12	5.0	-6.1	9.9e-10	-0.60	0.98	0.02	FALSE
22	GTEx	Breast Mammary Tissue	RP4-607J23.2	0.26	0.16	lasso	6	0.31	2.1e-16	5.0	-6.1	1.2e-09	-0.62	1.00	0.00	FALSE
42	GTEx	Nerve Tibial	RP4-607J23.2	0.35	0.26	lasso	6	0.34	4.6e-25	5.9	-6.1	1.4e-09	-0.63	1.00	0.00	FALSE
40	GTEx	Muscle Skeletal	RP4-607J23.2	0.06	0.08	lasso	2	0.08	1.9e-08	5.0	-6.0	1.6e-09	-0.57	0.89	0.04	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	BRI3	0.04	0.05	lasso	3	0.05	2.1e-05	5.9	6.0	1.6e-09	0.71	0.05	0.94	FALSE
27	GTEx	Cells EBV-transformed lymphocytes	RP4-607J23.2	0.15	0.15	lasso	2	0.15	1.6e-05	5.9	-6.0	1.9e-09	-0.70	0.18	0.38	FALSE
38	GTEx	Lung	RP4-607J23.2	0.25	0.18	lasso	7	0.25	2.2e-19	5.9	-6.0	2.1e-09	-0.63	1.00	0.00	FALSE
1	GTEx	Adipose Subcutaneous	RP4-607J23.2	0.33	0.32	lasso	4	0.36	1.6e-30	5.0	-6.0	2.3e-09	-0.56	1.00	0.00	FALSE
56	GTEx	Spleen	RP11-307C18.1	0.24	0.15	enet	17	0.21	5.2e-06	4.6	-5.9	2.7e-09	-0.64	0.09	0.76	FALSE
28	GTEx	Cells Transformed fibroblasts	RP4-607J23.2	0.57	0.25	lasso	17	0.31	8.1e-24	5.0	-5.9	3.1e-09	-0.56	1.00	0.00	FALSE
15	GTEx	Brain Cerebellum	RP4-607J23.2	0.43	0.22	lasso	7	0.29	3.9e-09	5.9	-5.9	3.6e-09	-0.64	0.72	0.26	FALSE
53	GTEx	Skin Sun Exposed Lower leg	RP11-307C18.1	0.19	0.10	enet	8	0.18	1.1e-14	4.4	-5.9	4.3e-09	-0.60	1.00	0.00	FALSE
63	GTEx	Uterus	RP4-607J23.2	0.31	0.12	lasso	6	0.25	8.8e-06	5.0	-5.9	4.5e-09	-0.54	0.17	0.53	FALSE
25	GTEx	Breast Mammary Tissue (Female)	RP11-307C18.1	0.20	0.08	enet	10	0.16	1.3e-05	5.9	-5.9	4.6e-09	-0.64	0.38	0.35	FALSE
34	GTEx	Esophagus Muscularis	RP4-607J23.2	0.38	0.23	lasso	6	0.32	7.2e-20	5.9	-5.9	4.7e-09	-0.61	1.00	0.00	FALSE
31	GTEx	Colon Transverse	RP4-607J23.2	0.22	0.11	lasso	3	0.17	1.3e-08	4.4	-5.8	6.6e-09	-0.57	0.89	0.09	FALSE
44	GTEx	Pancreas	BRI3	0.17	0.17	lasso	2	0.15	5.4e-07	5.0	5.7	1.3e-08	0.50	0.72	0.08	FALSE
45	GTEx	Prostate	RP4-607J23.2	0.38	0.16	enet	22	0.27	1.9e-07	5.3	-5.7	1.4e-08	-0.47	0.49	0.15	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	BAIAP2L1	0.11	0.05	blup	63	0.06	1.9e-06	5.0	5.7	1.4e-08	0.43	0.54	0.41	FALSE
16	GTEx	Brain Cerebellum	RP11-307C18.1	0.25	0.30	enet	22	0.33	1.7e-10	5.9	-5.7	1.5e-08	-0.66	0.87	0.10	FALSE
33	GTEx	Esophagus Mucosa	RP11-307C18.1	0.11	0.12	lasso	5	0.10	5.2e-07	5.3	-5.6	1.6e-08	-0.69	0.86	0.13	FALSE
52	GTEx	Skin Sun Exposed Lower leg	RP4-607J23.2	0.28	0.20	enet	23	0.27	1.1e-22	5.0	-5.6	2.5e-08	-0.59	1.00	0.00	FALSE
62	GTEx	Thyroid	RP4-607J23.2	0.21	0.20	enet	10	0.26	2.1e-20	5.0	-5.6	2.8e-08	-0.57	1.00	0.00	FALSE
21	GTEx	Brain Putamen basal ganglia	RP11-307C18.1	0.33	0.18	lasso	2	0.11	1.2e-03	4.9	-5.5	3.2e-08	-0.43	0.10	0.09	FALSE
10	GTEx	Artery Tibial	BRI3	0.08	0.01	enet	27	0.01	3.9e-02	-6.0	-5.5	4.2e-08	-0.67	0.10	0.86	FALSE
29	GTEx	Cells Transformed fibroblasts	RP11-307C18.1	0.13	0.09	lasso	4	0.06	1.9e-05	4.9	-5.5	4.2e-08	-0.47	0.93	0.03	FALSE
66	NTR	Blood	TECPR1	0.04	0.07	lasso	3	0.06	4.0e-20	5.4	5.5	4.9e-08	0.67	1.00	0.00	FALSE
35	GTEx	Esophagus Muscularis	RP11-307C18.1	0.25	0.18	lasso	6	0.19	1.7e-11	5.9	-5.4	5.3e-08	-0.59	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-307C18.1	0.28	0.16	enet	31	0.28	1.2e-14	5.4	-5.4	6.8e-08	-0.63	1.00	0.00	FALSE
17	GTEx	Brain Cortex	RP11-307C18.1	0.21	0.13	lasso	5	0.17	1.6e-05	4.6	-5.4	6.9e-08	-0.48	0.49	0.07	FALSE
59	GTEx	Thyroid	BAIAP2L1	0.09	0.06	enet	27	0.07	3.9e-06	5.4	5.4	7.4e-08	0.68	0.93	0.06	FALSE
58	GTEx	Testis	RP4-607J23.2	0.23	0.09	lasso	8	0.10	2.6e-05	5.3	-5.4	8.4e-08	-0.61	0.69	0.11	FALSE
30	GTEx	Colon Sigmoid	RP4-607J23.2	0.30	0.22	lasso	4	0.14	1.2e-05	4.9	-5.4	8.8e-08	-0.48	0.84	0.04	FALSE
11	GTEx	Artery Tibial	LMTK2	0.11	0.00	enet	17	0.03	1.0e-03	3.2	-5.3	9.6e-08	-0.54	0.03	0.85	FALSE
57	GTEx	Stomach	RP4-607J23.2	0.10	0.06	lasso	4	0.03	1.4e-02	5.3	-5.3	1.4e-07	-0.67	0.18	0.09	FALSE
18	GTEx	Brain Frontal Cortex BA9	RP4-607J23.2	0.18	0.08	lasso	5	0.08	3.2e-03	5.0	-5.3	1.5e-07	-0.42	0.06	0.36	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	BAIAP2L1	0.04	0.03	blup	64	0.03	7.6e-07	-6.1	-5.2	1.8e-07	-0.55	0.03	0.97	FALSE
20	GTEx	Brain Hypothalamus	RP11-307C18.1	0.32	0.27	lasso	3	0.23	4.7e-06	4.4	-5.2	1.9e-07	-0.46	0.22	0.31	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	TECPR1	0.16	0.25	lasso	7	0.24	3.2e-31	5.4	5.2	1.9e-07	0.67	1.00	0.00	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	RP4-607J23.2	0.36	0.22	lasso	5	0.26	1.2e-14	5.0	-5.2	2.0e-07	-0.53	1.00	0.00	FALSE