Hub : Genes

TAX1BP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.2100	0.0800	2.0e-03	0.059	NA	0.007	NA	0.087	1.1e-02	NA	2.0e-01	NA	2.5e-03
2	GTEx	Testis	0.3100	0.0610	1.4e-09	0.275	NA	0.278	NA	0.277	1.3e-12	NA	9.0e-13	NA	1.1e-12
3	ROSMAP	Brain Pre-frontal Cortex	0.0962	0.0266	4.2e-08	0.027	0.064	0.057	0.065	0.054	2.0e-04	1.3e-08	6.5e-08	8.3e-09	1.5e-07
4	YFS	Blood	0.0248	0.0100	5.0e-04	0.007	0.016	0.007	0.017	0.009	2.1e-03	3.3e-06	2.0e-03	1.7e-06	3.5e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	1.3	-0.1	0.2	1.1	0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	0.8	0.3	0.4	0.6
Depressed Affect (Nagel 2018)	0.7	1.4	4.5	0.0	1.0	2.1	-0.2
Depression (Nagel 2018)	0.3	0.4	1.3	-0.0	-0.7	-0.1	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.2	-1.5	0.6	1.3	1.2
Neuroticism (Nagel 2018)	0.6	1.3	3.8	-0.4	1.1	1.9	0.3
Schizophrenia (2018)	0.2	0.5	1.3	1.2	0.3	-0.5	0.6
Schizophrenia vs Biploar Disorder	0.5	0.7	2.3	0.4	1.5	0.4	0.3
Worry (Nagel 2018)	0.1	0.1	0.2	0.4	0.5	0.2	0.1
Alzheimer’s Disease (in mother)	1.4	1.7	3.8	-1.3	0.8	0.7	2.0
Alzheimer’s Disease (in father)	1.7	1.8	2.3	1.4	-1.1	-1.5	-1.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.6	-0.5	-0.6	0.9
Crohns Disease (2017)	1.4	3.0	7.5	-0.4	-1.3	-1.6	-2.7
Irritable Bowel Disease (IBD)	0.2	0.5	0.7	0.4	-0.6	-0.8	-0.9
Ulcerative Colitis (UC)	0.3	0.6	2.2	0.0	0.2	0.5	1.5
Major Depression (MDD)	1.6	1.9	3.8	-1.7	1.0	1.9	0.1
Reaction Time	1.5	2.9	6.5	0.7	2.5	1.3	1.8
Verbal and Numeric Reasoning (VNR)	0.8	1.8	3.0	-1.7	0.9	1.2	1.4
Breast Cancer	1.3	3.1	5.4	2.3	-0.6	-1.5	-2.1
Ovarian Cancer	0.4	0.6	1.4	0.8	1.2	0.2	-0.6
Prostate Cancer	33.0	46.4	69.6	-4.8	5.4	8.3	8.0
Age at First Birth	0.1	0.2	0.4	-0.6	-0.2	-0.4	-0.2
Bipolar Disorder (2011)	0.2	0.2	0.8	0.2	-0.2	-0.9	0.2
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	-0.3	-0.5	-0.3	-0.6
Coronary Artery Disease (CAD)	2.9	3.4	5.6	-1.9	2.1	2.4	0.1
Crohns Disease (2012)	1.4	2.3	5.8	-0.1	-1.3	-1.4	-2.4
Mean Putamen Volume	2.9	3.4	6.0	2.4	-0.8	-2.0	-1.6
Fasting Glucose	0.2	0.2	0.9	1.0	-0.1	-0.1	0.1
HbA1C	0.5	0.6	1.3	0.4	-0.6	-1.1	-0.6
HDL Cholesterol	0.1	0.1	0.3	0.5	0.1	-0.2	0.6
LDL Cholesterol	0.4	0.7	1.3	0.7	-0.5	-0.8	-1.1
Lupus	0.7	1.1	3.2	0.2	-0.8	-0.8	-1.8
Neuroticism (2016)	1.1	1.6	3.0	-1.0	1.2	1.7	0.9
Primary Biliary Cirrhosis	0.2	0.2	0.4	-0.1	-0.5	-0.7	-0.4
Rheumatoid Arthritis	0.3	0.4	0.6	0.8	0.7	-0.6	-0.3
Schizophrenia (2014)	0.4	0.8	2.7	1.7	-0.0	-0.6	-0.0
Triglycerides	0.4	0.6	1.8	-0.5	-0.5	-0.2	-1.3
Type 2 Diabetes (T2D) (2012)	1.7	2.0	5.6	-0.6	-1.2	-0.7	-2.4
Ulcerative Colitis	0.2	0.3	1.0	0.2	0.1	0.6	1.0
Blood Eosinophil Count	0.5	3.5	10.1	0.0	3.2	1.9	-0.6
Blood Platelet Count	0.0	0.5	1.2	0.5	-1.1	-0.1	0.7
Blood Red Count	0.2	1.5	4.4	-2.1	0.7	0.5	0.9
Blood White Count	0.3	1.9	3.1	-1.8	-0.9	0.8	1.7
Heel T-Score	7.2	57.2	123.2	-3.7	-11.1	-6.5	-7.0
BMI	0.1	0.9	1.4	-1.2	-0.4	1.0	-0.9
Height	0.2	3.5	8.9	-1.1	1.9	3.0	-0.5
Waist Hip Ratio (WHR)	0.6	2.5	5.8	-2.4	1.3	1.6	-0.2
Systolic Blood Pressure	1.5	7.7	23.7	-4.9	-0.1	1.4	2.3
Smoking Status	0.3	0.7	1.6	0.2	0.5	1.3	-1.0
Allergy or Eczema	1.8	4.7	7.3	1.5	-2.0	-2.7	-2.3
Cardiovascular Disease	3.8	12.6	22.9	-4.8	1.1	3.5	3.7
Hypothyroidism (self reported)	1.1	2.6	3.8	2.0	-1.8	-1.6	-0.9
Respiratory disease	3.1	6.9	9.6	2.5	-2.3	-3.1	-2.5
Type 2 Diabetes (T2D) (2018)	1.5	2.7	7.4	-2.7	1.0	1.5	-0.5
Lung FEV1/FVC ratio	0.6	2.9	4.8	-1.1	1.0	2.1	2.2
Lung FVC	1.3	6.4	16.7	0.2	-3.0	-4.1	0.4
Neuroticism	0.9	2.2	5.7	-0.5	1.6	2.4	0.2
Chronotype (morning person)	0.7	1.7	3.2	1.8	-0.4	-1.2	-1.4
Hair Pigment	0.1	3.9	9.1	2.3	1.0	-0.3	-3.0
Tanning	0.3	3.3	8.8	-0.0	3.0	2.1	0.5
Hand grip strength (left)	4.3	11.4	18.5	2.3	-3.7	-4.3	-2.8
Number of treatments/medications taken	0.2	0.4	0.9	-0.7	-0.0	0.9	-0.1
Average weekly spirits intake	1.2	1.5	2.7	-0.5	1.5	1.6	-0.8
Sensitivity / hurt feelings	0.4	0.8	2.3	1.5	0.3	0.1	-0.8
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.3	0.2	0.5	0.4
Hearing difficulty/problems: Yes	0.5	0.8	2.0	-1.4	0.1	0.6	0.9
Relative age of first facial hair	0.6	1.3	3.2	0.9	-1.0	-1.8	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	0.9	0.8	1.0	0.8	0.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.5	0.2	0.6	-0.1	-1.6
Ever had hysterectomy (womb removed)	0.7	0.8	1.2	-1.1	-0.3	0.8	-1.1
Systolic blood pressure, automated reading	1.3	3.9	14.3	-3.8	-0.4	0.3	1.0
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.9	1.6	-0.4	-1.7	0.1
Angina	0.9	1.2	3.3	-0.6	0.9	1.8	0.6
Medication for hormone replacement therapy	1.0	1.2	3.3	-0.5	1.8	1.0	-0.4
Vitamin and mineral supplements	0.2	0.2	0.5	0.7	0.0	0.1	0.6
Supplements: Zinc	0.5	0.6	1.2	0.7	-0.2	-0.8	1.1
Medication: Co-codamol	0.3	0.4	0.9	0.0	-0.9	-0.7	-0.3
Medication: Metformin	1.6	2.2	3.7	-1.9	1.3	1.0	-1.6
Diabetes (father)	2.8	3.4	6.8	-1.9	1.6	2.6	0.8
Diabetes (mother)	1.5	1.9	6.0	-0.3	-0.9	-0.7	-2.5
Severe depression (siblings)	0.3	0.3	0.7	-0.1	0.2	-0.8	-0.7
Pack years adult smoking proportion	0.3	0.4	1.0	0.7	1.0	0.5	-0.2
Impedance of leg (right)	1.6	7.9	13.1	-2.5	3.5	3.6	0.5
Leg fat-free mass (left)	0.1	0.6	1.4	0.0	-1.2	-0.5	-0.8
Trunk fat percentage	1.8	7.4	15.5	-3.2	1.8	3.9	-0.9
Hand grip strength (right)	4.7	12.7	18.2	3.2	-3.3	-4.3	-3.5
Townsend deprivation index at recruitment	1.0	1.4	2.0	0.7	-1.4	-1.1	-1.4
Current tobacco smoking	0.3	0.5	1.6	1.2	0.2	0.1	-0.7
Average weekly fortified wine intake	1.4	1.7	6.1	-0.0	-0.1	0.8	2.5
Maternal smoking around birth	0.1	0.2	0.5	0.7	-0.3	0.3	-0.2
Fed-up feelings	0.1	0.2	0.7	0.3	0.1	0.8	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.1	1.1	-1.7	-1.1	-0.8
Relative age voice broke	1.0	1.5	2.7	0.8	-1.4	-1.6	0.9
Taking other prescription medications	0.4	0.6	1.1	-0.3	0.8	1.1	-0.7
Age when periods started (menarche)	0.4	1.0	2.8	1.7	0.1	-0.8	-0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.9	-0.5	-0.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	6.3	14.2	25.4	-1.5	-5.0	-3.0	-4.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	0.4	-0.4	-0.7	0.5
Qualifications: CSEs or equivalent	2.9	3.8	6.7	2.1	-1.4	-1.5	-2.6
Serious illness, injury or assault to yourself	3.2	3.8	10.3	-0.4	1.1	1.9	3.2
High blood pressure	2.2	6.2	12.8	-3.6	0.4	2.1	2.8
Hayfever, allergic rhinitis or eczema	1.6	3.4	5.0	0.7	-2.1	-2.2	-1.9
Multivitamins +/- minerals	0.1	0.1	0.4	-0.6	-0.1	0.1	-0.3
Stomach or abdominal pain in last month	0.1	0.2	0.4	-0.4	0.7	0.3	-0.2
Supplements: Glucosamine	0.5	0.7	2.0	-0.1	-1.4	-0.9	-0.1
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	2.6	-0.8	1.6	1.4	1.2
Medication: Atenolol	0.9	1.2	2.0	-1.1	0.4	1.2	1.4
Medication: Levothyroxine sodium	1.7	2.9	5.0	2.2	-1.7	-1.8	-0.6
Sitting height	0.3	2.5	5.4	-2.1	-2.3	-0.1	0.3
Chronic bronchitis/emphysema (father)	0.6	0.6	1.0	0.9	-1.0	0.6	0.6
High blood pressure (mother)	0.6	0.8	1.8	-1.4	-0.8	-0.5	-0.8
Body mass index (BMI)	0.3	1.2	2.9	-1.1	-0.5	0.4	-1.7
Impedance of leg (left)	1.6	7.9	13.6	-2.7	3.2	3.7	0.2
Leg predicted mass (left)	0.1	0.6	1.5	0.1	-1.2	-0.6	-0.8
Trunk fat mass	1.3	5.7	11.3	-2.9	1.5	3.4	-1.1
Waist circumference	0.9	3.4	5.4	-2.3	0.9	1.9	-1.9
Number of incorrect matches in round	1.1	1.9	6.1	2.5	0.4	-1.1	-0.2
Past tobacco smoking	0.9	1.6	3.3	1.3	0.4	-1.1	1.8
Alcohol usually taken with meals	0.7	1.1	1.5	-1.2	0.9	1.2	0.7
Nervous feelings	0.3	0.5	1.3	0.8	0.0	-0.0	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	4.4	2.1	-1.4	-1.3	0.4
Hearing difficulty/problems with background noise	0.2	0.3	0.6	0.8	-0.1	-0.7	0.1
Hair/balding pattern: Pattern 2	4.9	6.2	9.8	0.4	-2.6	-3.1	-2.8
Had menopause	0.3	0.4	0.9	-0.8	0.0	0.4	1.0
Had other major operations	0.3	0.4	0.8	0.9	-0.0	0.0	0.9
Forced vital capacity (FVC)	0.2	0.7	1.5	-1.2	-0.9	-0.6	0.2
Heel bone mineral density (BMD) T-score, automated (right)	7.2	16.4	28.7	-1.3	-5.4	-3.2	-5.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	0.3	-0.2	0.1	0.4
Qualifications: None of the above	1.6	3.5	4.6	2.1	-1.5	-1.7	-2.1
Financial difficulties in last 2 years	1.8	2.4	3.9	0.2	-1.6	-1.8	-2.0
Mouth/teeth dental problems	0.6	1.0	2.6	-1.0	0.6	0.1	1.6
Heart attack	1.6	2.1	4.9	-1.0	1.1	2.2	1.1
Allergy	2.1	4.8	6.4	-1.3	2.4	2.5	2.3
Pain all over the body in last month	2.2	2.4	6.9	1.1	-0.5	-1.1	-2.6
Diabetes (self-reported)	1.8	2.7	7.1	-2.7	0.5	1.5	-1.1
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	6.3	1.2	-1.3	-2.3	-2.5
Medication: Ramipril	0.8	1.0	1.8	-1.4	-0.3	1.4	0.4
Medication: Simvastatin	1.6	2.4	4.3	-0.7	2.1	1.7	1.4
Fluid intelligence score	1.1	2.3	4.9	-2.2	1.2	1.1	1.3
Illnesses of siblings	0.7	0.9	1.5	1.2	0.9	-1.0	0.7
Neuroticism score	0.4	0.9	2.1	0.7	1.0	1.5	0.4
Weight	0.4	1.8	3.4	-1.9	0.2	1.6	-1.2
Impedance of arm (right)	3.3	15.5	34.3	-2.5	3.9	5.9	2.5
Arm fat percentage (right)	1.8	6.9	15.0	-3.1	1.8	3.9	-0.4
Trunk fat-free mass	0.2	1.0	1.6	0.2	-0.9	-1.3	-1.3
Hip circumference	0.5	2.2	4.1	-1.7	0.7	2.0	-1.2
Time employed in main current job	0.9	1.1	1.5	0.9	-0.9	-1.1	-1.2
Alcohol intake versus 10 years previously	1.2	1.8	6.4	-2.5	-0.5	0.9	0.0
Father’s age at death	0.8	1.1	3.1	-0.6	1.8	0.8	0.6
Worrier / anxious feelings	1.2	2.4	4.6	-1.2	0.9	2.1	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.6	0.8	-0.2	0.5	-0.7
Falls in the last year	3.6	4.9	9.5	-0.2	2.6	3.1	1.8
Hair/balding pattern: Pattern 3	1.2	1.8	2.9	-0.2	1.5	1.5	1.7
Number of live births	1.5	2.1	3.5	0.5	1.8	1.9	1.2
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.7	-1.3	-0.6	-0.3	1.1
Pulse rate	0.9	1.6	2.3	1.0	-1.5	-1.4	-1.1
Happiness	0.8	1.0	1.7	-0.7	1.1	1.3	0.6
Noisy workplace	0.7	0.9	1.2	1.0	-0.8	-1.1	0.9
Qualifications: A levels/AS levels or equivalent	1.7	3.7	8.4	-2.9	0.6	0.9	2.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.2	0.2	-0.5	0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.8	-0.4	0.2	-0.6
Asthma	0.7	1.4	3.1	0.9	-1.0	-1.8	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.8	1.7	0.5	0.4	0.4
Medication: Cholesterol lowering	1.6	2.5	3.2	-1.3	1.7	1.8	1.5
Depression (self-reported)	0.8	0.9	2.2	0.3	-1.5	-0.5	1.1
Medication: Lansoprazole	0.5	0.5	1.3	-0.0	0.8	0.4	-1.1
Prospective memory result	0.4	0.5	1.7	0.5	-1.3	-0.4	0.0
Lung cancer (father)	1.1	1.3	3.7	1.9	-0.1	-1.2	-0.3
Illnesses of mother	1.0	1.2	3.1	1.8	1.2	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	5.6	-1.5	-0.6	-0.5	2.4
Pulse wave Arterial Stiffness index	1.4	1.7	4.5	-2.1	0.9	1.1	-0.3
Impedance of arm (left)	2.9	13.4	28.2	-2.1	3.6	5.3	2.8
Arm fat mass (right)	0.8	3.2	6.0	-2.3	0.6	2.5	-1.1
Trunk predicted mass	0.2	1.0	1.6	0.3	-0.9	-1.3	-1.2
Standing height	0.3	2.7	5.7	-1.6	1.2	2.4	1.0
Length of working week for main job	0.5	0.6	0.9	0.6	-0.9	0.4	-0.9
Exposure to tobacco smoke at home	1.3	1.4	3.9	2.0	0.7	-1.1	-0.5
Breastfed as a baby	0.1	0.2	0.4	0.6	0.1	-0.3	-0.5
Tense / ‘highly strung’	0.7	1.2	2.1	1.5	1.4	0.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.3	-0.2	0.3	-0.4
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	-0.9	0.9	0.6	-0.0
Birth weight of first child	0.7	1.3	4.8	-0.5	-0.2	-0.1	2.2
Peak expiratory flow (PEF)	0.2	0.4	1.3	-1.1	0.3	0.1	0.4
Pulse wave reflection index	1.3	1.6	2.1	-1.4	1.3	1.4	1.0
Ever highly irritable/argumentative for 2 days	2.7	3.3	4.8	1.4	-1.6	-1.9	-2.2
Loud music exposure frequency	1.0	1.1	2.6	1.6	0.6	-0.0	-1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.8	0.5	-0.9	-0.5	0.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.8	-0.3	-0.5	-0.1	-1.3
Blood clot in the leg (DVT)	0.8	1.0	2.7	0.2	-1.6	-0.9	-0.6
Medication: Paracetamol	0.2	0.4	1.4	0.3	-0.1	0.2	-1.2
Headache pain in last month	0.3	0.5	1.6	0.4	-0.3	0.4	-1.3
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	4.5	2.1	-1.6	-2.1	-1.5
Glaucoma (self-reported)	0.2	0.2	0.7	0.8	0.3	-0.2	0.4
Gout (self-reported)	0.5	0.7	1.2	-0.6	1.1	1.1	-0.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	3.9	2.0	-1.4	-0.8	-0.7
Medication: Amlodipine	0.7	1.0	2.0	1.1	-0.7	-0.4	1.4
Medication: Ventolin 100micrograms inhaler	1.2	1.6	2.4	0.6	-1.5	-1.1	-1.5
Birth weight	2.4	5.2	9.2	-3.0	1.3	2.5	1.9
Chronic bronchitis/emphysema (mother)	1.3	1.6	2.9	-1.7	0.2	0.9	1.6
High blood pressure (siblings)	0.8	1.1	3.1	-1.8	0.0	1.2	0.2
Forced vital capacity (FVC), Best measure	0.5	2.0	2.8	-1.7	-1.5	-0.9	1.5
Body fat percentage	1.8	7.2	13.3	-3.3	1.8	3.6	-1.1
Leg fat percentage (right)	1.8	6.4	9.8	-3.1	2.0	3.0	-1.6
Arm fat-free mass (right)	0.6	2.9	4.4	0.5	-1.8	-2.1	-2.0
Exposure to tobacco smoke outside home	1.1	1.4	2.4	1.1	1.5	1.0	1.1
Comparative body size at age 10	1.9	5.2	7.9	-2.8	1.2	2.7	2.0
Number of full brothers	1.7	2.2	3.9	1.3	-2.0	-1.3	-1.2
Worry too long after embarrassment	1.5	2.5	4.9	-1.7	0.8	1.2	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.1	1.0	0.8	1.0	0.7
Wheeze or whistling in the chest in last year	3.5	6.2	13.8	2.2	-1.6	-1.9	-3.7
Number of children fathered	1.4	1.6	3.1	-1.5	1.0	1.8	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.4	-0.3	-1.8	0.5	0.4
Age at first live birth	0.6	1.1	2.2	-0.1	-1.5	-1.1	1.1
Pulse wave peak to peak time	1.1	1.3	3.9	2.0	-0.7	-0.8	0.4
Health satisfaction	0.3	0.3	0.6	0.8	-0.7	-0.2	-0.4
Shortness of breath walking on level ground	0.5	0.6	1.3	1.0	-0.0	0.4	-1.1
Qualifications: College or University degree	2.3	7.1	12.9	-2.3	2.3	2.3	3.6
Eye problems/disorders: None of the above	0.4	0.5	1.7	0.3	-1.3	-0.4	-0.0
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	0.2	-0.2	-0.4	-0.8
Emphysema/chronic bronchitis	1.3	1.4	3.5	1.3	-0.7	-0.4	-1.9
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	-0.2	-0.1	-0.0	0.0
Neck or shoulder pain in last month	0.6	0.8	1.4	1.0	0.9	1.2	0.3
Medication: Blood pressure	0.9	1.7	2.3	-1.2	0.8	1.5	1.5
Angina (self-reported)	0.9	1.1	3.5	-0.6	0.7	1.9	0.4
Migraine (self-reported)	0.4	0.5	1.7	-1.3	0.1	-0.5	-0.2
Medication: Ibuprofen	0.7	0.8	3.2	1.8	0.2	0.2	0.2
Medication: Allopurinol	0.5	0.6	1.5	-0.6	0.6	1.2	0.5
Medication: Omeprazole	0.6	0.7	1.9	-1.4	0.2	0.4	-0.9
Medication: Seretide 50 evohaler	1.0	1.2	2.5	1.6	-1.0	-0.8	-0.8
Mean time to correctly identify matches	1.6	3.0	5.7	1.4	2.4	0.7	2.0
Heart disease (mother)	1.5	1.8	3.5	0.8	-1.9	-1.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	0.3	-0.7	-0.1	-0.0
Whole body fat mass	1.2	5.1	8.9	-2.9	1.2	3.0	-1.2
Leg fat mass (right)	1.0	4.0	6.5	-2.6	1.1	2.2	-1.8
Arm predicted mass (right)	0.6	2.9	4.7	0.4	-1.8	-2.2	-2.0
Pulse rate, automated reading	0.4	1.4	4.2	0.0	-2.0	-0.9	-0.7
Alcohol intake frequency.	0.9	2.1	4.6	-1.2	-2.1	-1.4	0.4
Comparative height size at age 10	0.8	4.5	7.7	-1.2	1.2	2.8	2.7
Number of full sisters	0.5	0.6	1.9	1.4	0.1	-0.3	-0.7
Suffer from ‘nerves’	2.3	3.6	9.1	3.0	-1.0	-1.7	-1.2
Overall health rating	1.7	3.6	9.5	-1.7	1.4	3.1	0.1
Chest pain or discomfort	0.7	1.1	2.7	1.6	0.7	0.9	-0.4
Had major operations	0.7	0.8	2.0	-0.6	0.8	1.4	-0.2
Age at last live birth	0.4	0.5	0.9	0.3	-0.9	-0.9	0.6
Family relationship satisfaction	0.4	0.5	0.9	-0.6	-0.2	-0.7	-1.0
Leg pain on walking	1.4	1.8	4.7	2.2	-0.2	-0.7	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.9	0.5	-0.8	-0.7	-1.7
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.8	-0.1	-1.7	-0.5	-1.3
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.0	-0.6	1.7	1.4	1.3
Medication: Aspirin	0.7	0.9	1.5	-0.3	1.2	0.8	1.2
Supplements: Vitamin C	0.2	0.3	0.9	-0.3	0.4	-0.9	-0.0
Knee pain experienced in last month	0.8	1.3	4.2	2.1	0.1	0.2	-1.0
Hypertension (Self-reported)	2.0	5.6	11.3	-3.4	0.3	2.1	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.3	-1.5	-0.2	1.0	-0.2
Illnesses of father: Heart disease	2.0	2.8	3.0	-1.7	1.5	1.7	1.7
Illnesses of siblings: Diabetes	0.9	1.1	1.4	-1.1	-0.9	1.2	-0.9
Smoking status: Previous	1.2	1.8	3.5	-1.9	-0.2	1.4	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.0	-1.5	0.4	1.7	0.6
Whole body fat-free mass	0.2	1.1	1.6	0.2	-1.2	-1.2	-1.2
Leg fat-free mass (right)	0.2	0.8	2.0	0.2	-1.4	-0.8	-0.8
Arm fat percentage (left)	1.4	5.6	12.1	-2.8	1.5	3.5	-0.4
Average weekly red wine intake	1.3	1.9	3.2	-0.5	1.8	1.1	1.8
Handedness (chirality/laterality): Left-handed	1.5	1.8	2.4	-0.7	-1.5	-1.5	-1.4
Mood swings	0.7	1.2	2.1	0.9	1.4	1.3	0.4
Loneliness, isolation	0.7	0.9	1.8	1.3	-0.4	-0.3	-1.2
Long-standing illness, disability or infirmity	0.3	0.4	0.8	-0.3	-0.8	0.3	-0.9
Ever had bowel cancer screening	1.3	1.5	2.8	-0.7	1.5	1.7	0.5
Diabetes diagnosed by doctor	1.4	2.4	6.6	-2.6	0.0	1.0	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	-0.2	0.3	0.0	-0.2
Friendships satisfaction	0.9	1.1	2.4	-0.3	-0.6	-1.2	-1.5
Qualifications: nursing, teaching	0.2	0.3	0.9	-0.9	0.1	-0.4	0.1
Commuting to job workplace: Walk	0.5	0.5	1.2	-1.1	-0.6	0.4	0.5
Eye problems/disorders: Cataract	0.4	0.5	1.5	-1.2	-0.6	0.2	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.9	0.1	1.0	0.9	0.2
Medication for cholesterol	2.3	3.4	5.2	2.0	-1.6	-2.3	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	3.7	1.9	0.4	-1.4	-0.6
Back pain experienced in last month	0.2	0.3	0.7	-0.1	0.4	0.8	0.6
Mineral and other dietary supplements	0.3	0.3	1.3	1.1	0.1	-0.3	0.1
Breast cancer (self-reported)	1.0	1.1	2.3	1.2	0.9	-0.0	1.5
Asthma (self-reported)	0.8	1.6	3.2	1.1	-1.1	-1.8	-0.8
Osteoporosis (self-reported)	1.7	2.1	4.0	-1.0	1.0	2.0	1.5
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.0	-0.1	0.4	0.1
Medication: Aspirin	0.5	0.6	1.1	0.1	1.1	0.6	1.0
Medication: Gliclazide	0.7	0.8	1.5	-1.2	0.5	0.8	-0.9
Illnesses of father: None of the above (group 1)	2.0	2.5	3.9	1.7	-1.1	-1.4	-2.0
Smoking status: Current	0.6	0.9	2.4	1.6	-0.1	-0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.4	5.3	0.9	-1.3	-1.4	2.3
Whole body water mass	0.2	1.2	2.0	0.2	-1.1	-1.2	-1.4
Leg predicted mass (right)	0.1	0.8	1.8	0.2	-1.3	-0.7	-0.8
Arm fat mass (left)	0.7	2.7	4.9	-2.1	0.7	2.2	-1.1
Number of self-reported non-cancer illnesses	0.3	0.6	1.3	-1.2	-1.0	0.3	-0.3
Average weekly champagne plus white wine intake	0.2	0.2	0.4	0.7	0.4	-0.2	0.6
Miserableness	0.2	0.4	0.8	0.9	0.5	0.6	0.4
Guilty feelings	1.1	1.7	3.8	-1.2	0.3	2.0	1.2
Wears glasses or contact lenses	2.3	2.6	4.5	-1.9	1.6	2.1	0.1
Ever taken oral contraceptive pill	0.6	0.7	1.3	-0.5	1.2	0.6	0.9
Hearing aid user	0.0	0.1	0.2	0.4	0.1	-0.0	-0.1
Mother’s age at death	0.2	0.2	0.4	0.4	-0.1	-0.6	-0.5
Financial situation satisfaction	0.6	0.7	1.5	-0.5	0.9	1.2	0.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	-0.8	-0.9	-0.7	0.1
Commuting to job workplace: Public transport	1.6	2.0	5.6	-0.8	0.4	1.2	2.4
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.2	0.3	0.1	0.0
Medication: Blood pressure	2.5	4.8	7.7	-2.2	1.0	2.4	2.8
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.4	0.7	1.5	0.7	-0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	-0.6	-0.6	0.3	-0.3
High cholesterol (Self-reported)	1.8	3.3	5.3	-1.0	2.3	2.0	1.7
Medication: Bendroflumethiazide	0.5	0.7	2.2	-0.5	0.1	0.5	1.5
Medication: Paracetamol	0.2	0.3	1.0	0.1	-0.1	0.3	-1.0
Medication: Lisinopril	1.5	1.9	3.2	-1.5	0.9	1.2	1.8
Medication: Atorvastatin	0.0	0.1	0.1	0.1	-0.3	0.2	0.3
Illnesses of father: High blood pressure	1.6	2.0	4.5	-2.1	0.2	0.9	1.6
Alcohol drinker status: Never	0.3	0.4	0.5	0.6	-0.4	-0.7	0.7
Ever smoked	0.6	1.0	2.2	-0.6	-0.7	0.9	-1.5
Basal metabolic rate	0.1	0.7	1.7	-0.3	-0.9	-0.5	-1.3
Leg fat percentage (left)	1.6	5.6	9.6	-3.1	1.6	2.6	-1.8
Arm fat-free mass (left)	0.5	2.3	3.7	0.1	-1.5	-1.8	-1.9
Number of operations (self-reported)	0.1	0.2	0.3	0.5	0.4	0.5	-0.4
Average weekly beer plus cider intake	0.2	0.3	0.9	0.9	-0.5	-0.0	-0.3
Irritability	1.4	2.5	5.2	0.7	2.3	2.0	0.3
Risk taking	0.5	0.7	2.6	1.6	0.5	0.0	0.2
Ever had prostate specific antigen (PSA) test	2.7	3.1	6.0	-1.2	2.4	2.0	1.0
Fractured/broken bones in last 5 years	1.6	2.0	3.8	0.6	1.9	1.8	0.8
Age started oral contraceptive pill	0.7	0.9	2.3	-1.5	-0.2	-0.0	1.1
Diastolic blood pressure, automated reading	1.3	4.1	10.2	-3.2	1.0	1.9	1.2
Ever depressed for a whole week	0.3	0.3	1.3	1.1	0.1	-0.1	-0.1
Unable to work because of sickness or disability	2.1	2.8	4.7	1.8	-0.9	-1.5	-2.2
Commuting to job workplace: Cycle	1.4	1.7	5.1	2.3	0.2	-0.6	1.1
Myopia	1.8	2.6	6.5	-2.5	1.2	1.3	0.9
Vascular/heart problems diagnosed by doctor	2.3	6.4	11.0	3.3	-0.6	-2.6	-2.7
Cholesterol lowering medication	2.1	3.1	4.7	-1.4	2.0	2.2	1.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.0	-1.3	0.6	1.4	-0.6
Pain experienced in last month	0.6	1.0	3.3	-1.8	-0.7	-0.5	0.3
Supplements: Calcium	2.2	2.4	5.2	-2.3	1.2	1.1	1.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.4	-0.2	0.1	-0.3
Heart attack/myocardial infarction (self-reported)	1.3	1.7	4.2	-0.8	1.0	2.0	1.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.6	0.3	-1.3	-0.7	-0.5
Heart disease (siblings)	0.3	0.4	0.9	-0.1	-0.8	0.2	-0.9
Alcohol drinker status: Previous	1.3	1.4	1.8	0.9	-1.3	-1.3	-1.2
Pack years of smoking	0.3	0.4	0.7	0.6	0.8	0.4	-0.5
Impedance of whole body	2.2	11.2	23.1	-2.4	3.6	4.8	1.8
Leg fat mass (left)	0.9	3.5	6.4	-2.5	0.7	1.9	-1.8
Arm predicted mass (left)	0.4	1.9	3.7	0.1	-1.4	-1.4	-1.9