Hub : Genes

TAX1BP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Nucleus accumbens basal ganglia 0.2100 0.0800 2.0e-03 0.059 NA 0.007 NA 0.087 1.1e-02 NA 2.0e-01 NA 2.5e-03
2 GTEx Testis 0.3100 0.0610 1.4e-09 0.275 NA 0.278 NA 0.277 1.3e-12 NA 9.0e-13 NA 1.1e-12
3 ROSMAP Brain Pre-frontal Cortex 0.0962 0.0266 4.2e-08 0.027 0.064 0.057 0.065 0.054 2.0e-04 1.3e-08 6.5e-08 8.3e-09 1.5e-07
4 YFS Blood 0.0248 0.0100 5.0e-04 0.007 0.016 0.007 0.017 0.009 2.1e-03 3.3e-06 2.0e-03 1.7e-06 3.5e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 1.3 -0.1 0.2 1.1 0.2
Bipolar Disorder or Schizophrenia 0.1 0.3 0.7 0.8 0.3 0.4 0.6
Depressed Affect (Nagel 2018) 0.7 1.4 4.5 0.0 1.0 2.1 -0.2
Depression (Nagel 2018) 0.3 0.4 1.3 -0.0 -0.7 -0.1 -1.1
Intelligence (Savage-Jansen 2018) 0.5 1.5 2.2 -1.5 0.6 1.3 1.2
Neuroticism (Nagel 2018) 0.6 1.3 3.8 -0.4 1.1 1.9 0.3
Schizophrenia (2018) 0.2 0.5 1.3 1.2 0.3 -0.5 0.6
Schizophrenia vs Biploar Disorder 0.5 0.7 2.3 0.4 1.5 0.4 0.3
Worry (Nagel 2018) 0.1 0.1 0.2 0.4 0.5 0.2 0.1
Alzheimer’s Disease (in mother) 1.4 1.7 3.8 -1.3 0.8 0.7 2.0
Alzheimer’s Disease (in father) 1.7 1.8 2.3 1.4 -1.1 -1.5 -1.3
Alzheimer’s Disease (including proxy) 0.3 0.4 0.8 -0.6 -0.5 -0.6 0.9
Crohns Disease (2017) 1.4 3.0 7.5 -0.4 -1.3 -1.6 -2.7
Irritable Bowel Disease (IBD) 0.2 0.5 0.7 0.4 -0.6 -0.8 -0.9
Ulcerative Colitis (UC) 0.3 0.6 2.2 0.0 0.2 0.5 1.5
Major Depression (MDD) 1.6 1.9 3.8 -1.7 1.0 1.9 0.1
Reaction Time 1.5 2.9 6.5 0.7 2.5 1.3 1.8
Verbal and Numeric Reasoning (VNR) 0.8 1.8 3.0 -1.7 0.9 1.2 1.4
Breast Cancer 1.3 3.1 5.4 2.3 -0.6 -1.5 -2.1
Ovarian Cancer 0.4 0.6 1.4 0.8 1.2 0.2 -0.6
Prostate Cancer 33.0 46.4 69.6 -4.8 5.4 8.3 8.0
Age at First Birth 0.1 0.2 0.4 -0.6 -0.2 -0.4 -0.2
Bipolar Disorder (2011) 0.2 0.2 0.8 0.2 -0.2 -0.9 0.2
Body Mass Index (BMI) (2010) 0.1 0.2 0.3 -0.3 -0.5 -0.3 -0.6
Coronary Artery Disease (CAD) 2.9 3.4 5.6 -1.9 2.1 2.4 0.1
Crohns Disease (2012) 1.4 2.3 5.8 -0.1 -1.3 -1.4 -2.4
Mean Putamen Volume 2.9 3.4 6.0 2.4 -0.8 -2.0 -1.6
Fasting Glucose 0.2 0.2 0.9 1.0 -0.1 -0.1 0.1
HbA1C 0.5 0.6 1.3 0.4 -0.6 -1.1 -0.6
HDL Cholesterol 0.1 0.1 0.3 0.5 0.1 -0.2 0.6
LDL Cholesterol 0.4 0.7 1.3 0.7 -0.5 -0.8 -1.1
Lupus 0.7 1.1 3.2 0.2 -0.8 -0.8 -1.8
Neuroticism (2016) 1.1 1.6 3.0 -1.0 1.2 1.7 0.9
Primary Biliary Cirrhosis 0.2 0.2 0.4 -0.1 -0.5 -0.7 -0.4
Rheumatoid Arthritis 0.3 0.4 0.6 0.8 0.7 -0.6 -0.3
Schizophrenia (2014) 0.4 0.8 2.7 1.7 -0.0 -0.6 -0.0
Triglycerides 0.4 0.6 1.8 -0.5 -0.5 -0.2 -1.3
Type 2 Diabetes (T2D) (2012) 1.7 2.0 5.6 -0.6 -1.2 -0.7 -2.4
Ulcerative Colitis 0.2 0.3 1.0 0.2 0.1 0.6 1.0
Blood Eosinophil Count 0.5 3.5 10.1 0.0 3.2 1.9 -0.6
Blood Platelet Count 0.0 0.5 1.2 0.5 -1.1 -0.1 0.7
Blood Red Count 0.2 1.5 4.4 -2.1 0.7 0.5 0.9
Blood White Count 0.3 1.9 3.1 -1.8 -0.9 0.8 1.7
Heel T-Score 7.2 57.2 123.2 -3.7 -11.1 -6.5 -7.0
BMI 0.1 0.9 1.4 -1.2 -0.4 1.0 -0.9
Height 0.2 3.5 8.9 -1.1 1.9 3.0 -0.5
Waist Hip Ratio (WHR) 0.6 2.5 5.8 -2.4 1.3 1.6 -0.2
Systolic Blood Pressure 1.5 7.7 23.7 -4.9 -0.1 1.4 2.3
Smoking Status 0.3 0.7 1.6 0.2 0.5 1.3 -1.0
Allergy or Eczema 1.8 4.7 7.3 1.5 -2.0 -2.7 -2.3
Cardiovascular Disease 3.8 12.6 22.9 -4.8 1.1 3.5 3.7
Hypothyroidism (self reported) 1.1 2.6 3.8 2.0 -1.8 -1.6 -0.9
Respiratory disease 3.1 6.9 9.6 2.5 -2.3 -3.1 -2.5
Type 2 Diabetes (T2D) (2018) 1.5 2.7 7.4 -2.7 1.0 1.5 -0.5
Lung FEV1/FVC ratio 0.6 2.9 4.8 -1.1 1.0 2.1 2.2
Lung FVC 1.3 6.4 16.7 0.2 -3.0 -4.1 0.4
Neuroticism 0.9 2.2 5.7 -0.5 1.6 2.4 0.2
Chronotype (morning person) 0.7 1.7 3.2 1.8 -0.4 -1.2 -1.4
Hair Pigment 0.1 3.9 9.1 2.3 1.0 -0.3 -3.0
Tanning 0.3 3.3 8.8 -0.0 3.0 2.1 0.5
Hand grip strength (left) 4.3 11.4 18.5 2.3 -3.7 -4.3 -2.8
Number of treatments/medications taken 0.2 0.4 0.9 -0.7 -0.0 0.9 -0.1
Average weekly spirits intake 1.2 1.5 2.7 -0.5 1.5 1.6 -0.8
Sensitivity / hurt feelings 0.4 0.8 2.3 1.5 0.3 0.1 -0.8
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 -0.3 0.2 0.5 0.4
Hearing difficulty/problems: Yes 0.5 0.8 2.0 -1.4 0.1 0.6 0.9
Relative age of first facial hair 0.6 1.3 3.2 0.9 -1.0 -1.8 -0.4
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 0.9 0.8 1.0 0.8 0.1
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.5 0.2 0.6 -0.1 -1.6
Ever had hysterectomy (womb removed) 0.7 0.8 1.2 -1.1 -0.3 0.8 -1.1
Systolic blood pressure, automated reading 1.3 3.9 14.3 -3.8 -0.4 0.3 1.0
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 2.9 1.6 -0.4 -1.7 0.1
Angina 0.9 1.2 3.3 -0.6 0.9 1.8 0.6
Medication for hormone replacement therapy 1.0 1.2 3.3 -0.5 1.8 1.0 -0.4
Vitamin and mineral supplements 0.2 0.2 0.5 0.7 0.0 0.1 0.6
Supplements: Zinc 0.5 0.6 1.2 0.7 -0.2 -0.8 1.1
Medication: Co-codamol 0.3 0.4 0.9 0.0 -0.9 -0.7 -0.3
Medication: Metformin 1.6 2.2 3.7 -1.9 1.3 1.0 -1.6
Diabetes (father) 2.8 3.4 6.8 -1.9 1.6 2.6 0.8
Diabetes (mother) 1.5 1.9 6.0 -0.3 -0.9 -0.7 -2.5
Severe depression (siblings) 0.3 0.3 0.7 -0.1 0.2 -0.8 -0.7
Pack years adult smoking proportion 0.3 0.4 1.0 0.7 1.0 0.5 -0.2
Impedance of leg (right) 1.6 7.9 13.1 -2.5 3.5 3.6 0.5
Leg fat-free mass (left) 0.1 0.6 1.4 0.0 -1.2 -0.5 -0.8
Trunk fat percentage 1.8 7.4 15.5 -3.2 1.8 3.9 -0.9
Hand grip strength (right) 4.7 12.7 18.2 3.2 -3.3 -4.3 -3.5
Townsend deprivation index at recruitment 1.0 1.4 2.0 0.7 -1.4 -1.1 -1.4
Current tobacco smoking 0.3 0.5 1.6 1.2 0.2 0.1 -0.7
Average weekly fortified wine intake 1.4 1.7 6.1 -0.0 -0.1 0.8 2.5
Maternal smoking around birth 0.1 0.2 0.5 0.7 -0.3 0.3 -0.2
Fed-up feelings 0.1 0.2 0.7 0.3 0.1 0.8 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 3.1 1.1 -1.7 -1.1 -0.8
Relative age voice broke 1.0 1.5 2.7 0.8 -1.4 -1.6 0.9
Taking other prescription medications 0.4 0.6 1.1 -0.3 0.8 1.1 -0.7
Age when periods started (menarche) 0.4 1.0 2.8 1.7 0.1 -0.8 -0.7
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.8 -0.9 -0.5 -0.2 0.2
Heel bone mineral density (BMD) T-score, automated (left) 6.3 14.2 25.4 -1.5 -5.0 -3.0 -4.5
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.5 0.4 -0.4 -0.7 0.5
Qualifications: CSEs or equivalent 2.9 3.8 6.7 2.1 -1.4 -1.5 -2.6
Serious illness, injury or assault to yourself 3.2 3.8 10.3 -0.4 1.1 1.9 3.2
High blood pressure 2.2 6.2 12.8 -3.6 0.4 2.1 2.8
Hayfever, allergic rhinitis or eczema 1.6 3.4 5.0 0.7 -2.1 -2.2 -1.9
Multivitamins +/- minerals 0.1 0.1 0.4 -0.6 -0.1 0.1 -0.3
Stomach or abdominal pain in last month 0.1 0.2 0.4 -0.4 0.7 0.3 -0.2
Supplements: Glucosamine 0.5 0.7 2.0 -0.1 -1.4 -0.9 -0.1
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 2.6 -0.8 1.6 1.4 1.2
Medication: Atenolol 0.9 1.2 2.0 -1.1 0.4 1.2 1.4
Medication: Levothyroxine sodium 1.7 2.9 5.0 2.2 -1.7 -1.8 -0.6
Sitting height 0.3 2.5 5.4 -2.1 -2.3 -0.1 0.3
Chronic bronchitis/emphysema (father) 0.6 0.6 1.0 0.9 -1.0 0.6 0.6
High blood pressure (mother) 0.6 0.8 1.8 -1.4 -0.8 -0.5 -0.8
Body mass index (BMI) 0.3 1.2 2.9 -1.1 -0.5 0.4 -1.7
Impedance of leg (left) 1.6 7.9 13.6 -2.7 3.2 3.7 0.2
Leg predicted mass (left) 0.1 0.6 1.5 0.1 -1.2 -0.6 -0.8
Trunk fat mass 1.3 5.7 11.3 -2.9 1.5 3.4 -1.1
Waist circumference 0.9 3.4 5.4 -2.3 0.9 1.9 -1.9
Number of incorrect matches in round 1.1 1.9 6.1 2.5 0.4 -1.1 -0.2
Past tobacco smoking 0.9 1.6 3.3 1.3 0.4 -1.1 1.8
Alcohol usually taken with meals 0.7 1.1 1.5 -1.2 0.9 1.2 0.7
Nervous feelings 0.3 0.5 1.3 0.8 0.0 -0.0 1.1
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.1 4.4 2.1 -1.4 -1.3 0.4
Hearing difficulty/problems with background noise 0.2 0.3 0.6 0.8 -0.1 -0.7 0.1
Hair/balding pattern: Pattern 2 4.9 6.2 9.8 0.4 -2.6 -3.1 -2.8
Had menopause 0.3 0.4 0.9 -0.8 0.0 0.4 1.0
Had other major operations 0.3 0.4 0.8 0.9 -0.0 0.0 0.9
Forced vital capacity (FVC) 0.2 0.7 1.5 -1.2 -0.9 -0.6 0.2
Heel bone mineral density (BMD) T-score, automated (right) 7.2 16.4 28.7 -1.3 -5.4 -3.2 -5.0
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.1 0.3 -0.2 0.1 0.4
Qualifications: None of the above 1.6 3.5 4.6 2.1 -1.5 -1.7 -2.1
Financial difficulties in last 2 years 1.8 2.4 3.9 0.2 -1.6 -1.8 -2.0
Mouth/teeth dental problems 0.6 1.0 2.6 -1.0 0.6 0.1 1.6
Heart attack 1.6 2.1 4.9 -1.0 1.1 2.2 1.1
Allergy 2.1 4.8 6.4 -1.3 2.4 2.5 2.3
Pain all over the body in last month 2.2 2.4 6.9 1.1 -0.5 -1.1 -2.6
Diabetes (self-reported) 1.8 2.7 7.1 -2.7 0.5 1.5 -1.1
Hayfever/allergic rhinitis (self-reported) 2.7 3.6 6.3 1.2 -1.3 -2.3 -2.5
Medication: Ramipril 0.8 1.0 1.8 -1.4 -0.3 1.4 0.4
Medication: Simvastatin 1.6 2.4 4.3 -0.7 2.1 1.7 1.4
Fluid intelligence score 1.1 2.3 4.9 -2.2 1.2 1.1 1.3
Illnesses of siblings 0.7 0.9 1.5 1.2 0.9 -1.0 0.7
Neuroticism score 0.4 0.9 2.1 0.7 1.0 1.5 0.4
Weight 0.4 1.8 3.4 -1.9 0.2 1.6 -1.2
Impedance of arm (right) 3.3 15.5 34.3 -2.5 3.9 5.9 2.5
Arm fat percentage (right) 1.8 6.9 15.0 -3.1 1.8 3.9 -0.4
Trunk fat-free mass 0.2 1.0 1.6 0.2 -0.9 -1.3 -1.3
Hip circumference 0.5 2.2 4.1 -1.7 0.7 2.0 -1.2
Time employed in main current job 0.9 1.1 1.5 0.9 -0.9 -1.1 -1.2
Alcohol intake versus 10 years previously 1.2 1.8 6.4 -2.5 -0.5 0.9 0.0
Father’s age at death 0.8 1.1 3.1 -0.6 1.8 0.8 0.6
Worrier / anxious feelings 1.2 2.4 4.6 -1.2 0.9 2.1 1.6
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.6 0.8 -0.2 0.5 -0.7
Falls in the last year 3.6 4.9 9.5 -0.2 2.6 3.1 1.8
Hair/balding pattern: Pattern 3 1.2 1.8 2.9 -0.2 1.5 1.5 1.7
Number of live births 1.5 2.1 3.5 0.5 1.8 1.9 1.2
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.7 -1.3 -0.6 -0.3 1.1
Pulse rate 0.9 1.6 2.3 1.0 -1.5 -1.4 -1.1
Happiness 0.8 1.0 1.7 -0.7 1.1 1.3 0.6
Noisy workplace 0.7 0.9 1.2 1.0 -0.8 -1.1 0.9
Qualifications: A levels/AS levels or equivalent 1.7 3.7 8.4 -2.9 0.6 0.9 2.3
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 0.2 0.2 -0.5 0.1
Mouth/teeth dental problems: Dentures 0.2 0.3 0.7 0.8 -0.4 0.2 -0.6
Asthma 0.7 1.4 3.1 0.9 -1.0 -1.8 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.8 1.7 0.5 0.4 0.4
Medication: Cholesterol lowering 1.6 2.5 3.2 -1.3 1.7 1.8 1.5
Depression (self-reported) 0.8 0.9 2.2 0.3 -1.5 -0.5 1.1
Medication: Lansoprazole 0.5 0.5 1.3 -0.0 0.8 0.4 -1.1
Prospective memory result 0.4 0.5 1.7 0.5 -1.3 -0.4 0.0
Lung cancer (father) 1.1 1.3 3.7 1.9 -0.1 -1.2 -0.3
Illnesses of mother 1.0 1.2 3.1 1.8 1.2 -0.3 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.1 5.6 -1.5 -0.6 -0.5 2.4
Pulse wave Arterial Stiffness index 1.4 1.7 4.5 -2.1 0.9 1.1 -0.3
Impedance of arm (left) 2.9 13.4 28.2 -2.1 3.6 5.3 2.8
Arm fat mass (right) 0.8 3.2 6.0 -2.3 0.6 2.5 -1.1
Trunk predicted mass 0.2 1.0 1.6 0.3 -0.9 -1.3 -1.2
Standing height 0.3 2.7 5.7 -1.6 1.2 2.4 1.0
Length of working week for main job 0.5 0.6 0.9 0.6 -0.9 0.4 -0.9
Exposure to tobacco smoke at home 1.3 1.4 3.9 2.0 0.7 -1.1 -0.5
Breastfed as a baby 0.1 0.2 0.4 0.6 0.1 -0.3 -0.5
Tense / ‘highly strung’ 0.7 1.2 2.1 1.5 1.4 0.4 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.1 -0.3 -0.2 0.3 -0.4
Hair/balding pattern: Pattern 4 0.2 0.5 0.8 -0.9 0.9 0.6 -0.0
Birth weight of first child 0.7 1.3 4.8 -0.5 -0.2 -0.1 2.2
Peak expiratory flow (PEF) 0.2 0.4 1.3 -1.1 0.3 0.1 0.4
Pulse wave reflection index 1.3 1.6 2.1 -1.4 1.3 1.4 1.0
Ever highly irritable/argumentative for 2 days 2.7 3.3 4.8 1.4 -1.6 -1.9 -2.2
Loud music exposure frequency 1.0 1.1 2.6 1.6 0.6 -0.0 -1.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.8 0.5 -0.9 -0.5 0.9
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.8 -0.3 -0.5 -0.1 -1.3
Blood clot in the leg (DVT) 0.8 1.0 2.7 0.2 -1.6 -0.9 -0.6
Medication: Paracetamol 0.2 0.4 1.4 0.3 -0.1 0.2 -1.2
Headache pain in last month 0.3 0.5 1.6 0.4 -0.3 0.4 -1.3
Medication for cholesterol, blood pressure or diabetes 2.1 3.4 4.5 2.1 -1.6 -2.1 -1.5
Glaucoma (self-reported) 0.2 0.2 0.7 0.8 0.3 -0.2 0.4
Gout (self-reported) 0.5 0.7 1.2 -0.6 1.1 1.1 -0.4
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 3.9 2.0 -1.4 -0.8 -0.7
Medication: Amlodipine 0.7 1.0 2.0 1.1 -0.7 -0.4 1.4
Medication: Ventolin 100micrograms inhaler 1.2 1.6 2.4 0.6 -1.5 -1.1 -1.5
Birth weight 2.4 5.2 9.2 -3.0 1.3 2.5 1.9
Chronic bronchitis/emphysema (mother) 1.3 1.6 2.9 -1.7 0.2 0.9 1.6
High blood pressure (siblings) 0.8 1.1 3.1 -1.8 0.0 1.2 0.2
Forced vital capacity (FVC), Best measure 0.5 2.0 2.8 -1.7 -1.5 -0.9 1.5
Body fat percentage 1.8 7.2 13.3 -3.3 1.8 3.6 -1.1
Leg fat percentage (right) 1.8 6.4 9.8 -3.1 2.0 3.0 -1.6
Arm fat-free mass (right) 0.6 2.9 4.4 0.5 -1.8 -2.1 -2.0
Exposure to tobacco smoke outside home 1.1 1.4 2.4 1.1 1.5 1.0 1.1
Comparative body size at age 10 1.9 5.2 7.9 -2.8 1.2 2.7 2.0
Number of full brothers 1.7 2.2 3.9 1.3 -2.0 -1.3 -1.2
Worry too long after embarrassment 1.5 2.5 4.9 -1.7 0.8 1.2 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.1 1.0 0.8 1.0 0.7
Wheeze or whistling in the chest in last year 3.5 6.2 13.8 2.2 -1.6 -1.9 -3.7
Number of children fathered 1.4 1.6 3.1 -1.5 1.0 1.8 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 3.4 -0.3 -1.8 0.5 0.4
Age at first live birth 0.6 1.1 2.2 -0.1 -1.5 -1.1 1.1
Pulse wave peak to peak time 1.1 1.3 3.9 2.0 -0.7 -0.8 0.4
Health satisfaction 0.3 0.3 0.6 0.8 -0.7 -0.2 -0.4
Shortness of breath walking on level ground 0.5 0.6 1.3 1.0 -0.0 0.4 -1.1
Qualifications: College or University degree 2.3 7.1 12.9 -2.3 2.3 2.3 3.6
Eye problems/disorders: None of the above 0.4 0.5 1.7 0.3 -1.3 -0.4 -0.0
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.6 0.2 -0.2 -0.4 -0.8
Emphysema/chronic bronchitis 1.3 1.4 3.5 1.3 -0.7 -0.4 -1.9
Medication for pain relief, constipation, heartburn 0.0 0.0 0.0 -0.2 -0.1 -0.0 0.0
Neck or shoulder pain in last month 0.6 0.8 1.4 1.0 0.9 1.2 0.3
Medication: Blood pressure 0.9 1.7 2.3 -1.2 0.8 1.5 1.5
Angina (self-reported) 0.9 1.1 3.5 -0.6 0.7 1.9 0.4
Migraine (self-reported) 0.4 0.5 1.7 -1.3 0.1 -0.5 -0.2
Medication: Ibuprofen 0.7 0.8 3.2 1.8 0.2 0.2 0.2
Medication: Allopurinol 0.5 0.6 1.5 -0.6 0.6 1.2 0.5
Medication: Omeprazole 0.6 0.7 1.9 -1.4 0.2 0.4 -0.9
Medication: Seretide 50 evohaler 1.0 1.2 2.5 1.6 -1.0 -0.8 -0.8
Mean time to correctly identify matches 1.6 3.0 5.7 1.4 2.4 0.7 2.0
Heart disease (mother) 1.5 1.8 3.5 0.8 -1.9 -1.6 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.5 0.3 -0.7 -0.1 -0.0
Whole body fat mass 1.2 5.1 8.9 -2.9 1.2 3.0 -1.2
Leg fat mass (right) 1.0 4.0 6.5 -2.6 1.1 2.2 -1.8
Arm predicted mass (right) 0.6 2.9 4.7 0.4 -1.8 -2.2 -2.0
Pulse rate, automated reading 0.4 1.4 4.2 0.0 -2.0 -0.9 -0.7
Alcohol intake frequency. 0.9 2.1 4.6 -1.2 -2.1 -1.4 0.4
Comparative height size at age 10 0.8 4.5 7.7 -1.2 1.2 2.8 2.7
Number of full sisters 0.5 0.6 1.9 1.4 0.1 -0.3 -0.7
Suffer from ‘nerves’ 2.3 3.6 9.1 3.0 -1.0 -1.7 -1.2
Overall health rating 1.7 3.6 9.5 -1.7 1.4 3.1 0.1
Chest pain or discomfort 0.7 1.1 2.7 1.6 0.7 0.9 -0.4
Had major operations 0.7 0.8 2.0 -0.6 0.8 1.4 -0.2
Age at last live birth 0.4 0.5 0.9 0.3 -0.9 -0.9 0.6
Family relationship satisfaction 0.4 0.5 0.9 -0.6 -0.2 -0.7 -1.0
Leg pain on walking 1.4 1.8 4.7 2.2 -0.2 -0.7 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.9 0.5 -0.8 -0.7 -1.7
Commuting to job workplace: Car/motor vehicle 1.0 1.2 2.8 -0.1 -1.7 -0.5 -1.3
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 3.0 -0.6 1.7 1.4 1.3
Medication: Aspirin 0.7 0.9 1.5 -0.3 1.2 0.8 1.2
Supplements: Vitamin C 0.2 0.3 0.9 -0.3 0.4 -0.9 -0.0
Knee pain experienced in last month 0.8 1.3 4.2 2.1 0.1 0.2 -1.0
Hypertension (Self-reported) 2.0 5.6 11.3 -3.4 0.3 2.1 2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 2.3 -1.5 -0.2 1.0 -0.2
Illnesses of father: Heart disease 2.0 2.8 3.0 -1.7 1.5 1.7 1.7
Illnesses of siblings: Diabetes 0.9 1.1 1.4 -1.1 -0.9 1.2 -0.9
Smoking status: Previous 1.2 1.8 3.5 -1.9 -0.2 1.4 -1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 3.0 -1.5 0.4 1.7 0.6
Whole body fat-free mass 0.2 1.1 1.6 0.2 -1.2 -1.2 -1.2
Leg fat-free mass (right) 0.2 0.8 2.0 0.2 -1.4 -0.8 -0.8
Arm fat percentage (left) 1.4 5.6 12.1 -2.8 1.5 3.5 -0.4
Average weekly red wine intake 1.3 1.9 3.2 -0.5 1.8 1.1 1.8
Handedness (chirality/laterality): Left-handed 1.5 1.8 2.4 -0.7 -1.5 -1.5 -1.4
Mood swings 0.7 1.2 2.1 0.9 1.4 1.3 0.4
Loneliness, isolation 0.7 0.9 1.8 1.3 -0.4 -0.3 -1.2
Long-standing illness, disability or infirmity 0.3 0.4 0.8 -0.3 -0.8 0.3 -0.9
Ever had bowel cancer screening 1.3 1.5 2.8 -0.7 1.5 1.7 0.5
Diabetes diagnosed by doctor 1.4 2.4 6.6 -2.6 0.0 1.0 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.1 -0.2 0.3 0.0 -0.2
Friendships satisfaction 0.9 1.1 2.4 -0.3 -0.6 -1.2 -1.5
Qualifications: nursing, teaching 0.2 0.3 0.9 -0.9 0.1 -0.4 0.1
Commuting to job workplace: Walk 0.5 0.5 1.2 -1.1 -0.6 0.4 0.5
Eye problems/disorders: Cataract 0.4 0.5 1.5 -1.2 -0.6 0.2 0.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.9 0.1 1.0 0.9 0.2
Medication for cholesterol 2.3 3.4 5.2 2.0 -1.6 -2.3 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.6 3.7 1.9 0.4 -1.4 -0.6
Back pain experienced in last month 0.2 0.3 0.7 -0.1 0.4 0.8 0.6
Mineral and other dietary supplements 0.3 0.3 1.3 1.1 0.1 -0.3 0.1
Breast cancer (self-reported) 1.0 1.1 2.3 1.2 0.9 -0.0 1.5
Asthma (self-reported) 0.8 1.6 3.2 1.1 -1.1 -1.8 -0.8
Osteoporosis (self-reported) 1.7 2.1 4.0 -1.0 1.0 2.0 1.5
Osteoarthritis (self-reported) 0.0 0.0 0.1 0.0 -0.1 0.4 0.1
Medication: Aspirin 0.5 0.6 1.1 0.1 1.1 0.6 1.0
Medication: Gliclazide 0.7 0.8 1.5 -1.2 0.5 0.8 -0.9
Illnesses of father: None of the above (group 1) 2.0 2.5 3.9 1.7 -1.1 -1.4 -2.0
Smoking status: Current 0.6 0.9 2.4 1.6 -0.1 -0.3 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.4 5.3 0.9 -1.3 -1.4 2.3
Whole body water mass 0.2 1.2 2.0 0.2 -1.1 -1.2 -1.4
Leg predicted mass (right) 0.1 0.8 1.8 0.2 -1.3 -0.7 -0.8
Arm fat mass (left) 0.7 2.7 4.9 -2.1 0.7 2.2 -1.1
Number of self-reported non-cancer illnesses 0.3 0.6 1.3 -1.2 -1.0 0.3 -0.3
Average weekly champagne plus white wine intake 0.2 0.2 0.4 0.7 0.4 -0.2 0.6
Miserableness 0.2 0.4 0.8 0.9 0.5 0.6 0.4
Guilty feelings 1.1 1.7 3.8 -1.2 0.3 2.0 1.2
Wears glasses or contact lenses 2.3 2.6 4.5 -1.9 1.6 2.1 0.1
Ever taken oral contraceptive pill 0.6 0.7 1.3 -0.5 1.2 0.6 0.9
Hearing aid user 0.0 0.1 0.2 0.4 0.1 -0.0 -0.1
Mother’s age at death 0.2 0.2 0.4 0.4 -0.1 -0.6 -0.5
Financial situation satisfaction 0.6 0.7 1.5 -0.5 0.9 1.2 0.6
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.8 -0.8 -0.9 -0.7 0.1
Commuting to job workplace: Public transport 1.6 2.0 5.6 -0.8 0.4 1.2 2.4
Eye problems/disorders: Glaucoma 0.0 0.0 0.1 0.2 0.3 0.1 0.0
Medication: Blood pressure 2.5 4.8 7.7 -2.2 1.0 2.4 2.8
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.4 0.7 1.5 0.7 -0.2
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 -0.6 -0.6 0.3 -0.3
High cholesterol (Self-reported) 1.8 3.3 5.3 -1.0 2.3 2.0 1.7
Medication: Bendroflumethiazide 0.5 0.7 2.2 -0.5 0.1 0.5 1.5
Medication: Paracetamol 0.2 0.3 1.0 0.1 -0.1 0.3 -1.0
Medication: Lisinopril 1.5 1.9 3.2 -1.5 0.9 1.2 1.8
Medication: Atorvastatin 0.0 0.1 0.1 0.1 -0.3 0.2 0.3
Illnesses of father: High blood pressure 1.6 2.0 4.5 -2.1 0.2 0.9 1.6
Alcohol drinker status: Never 0.3 0.4 0.5 0.6 -0.4 -0.7 0.7
Ever smoked 0.6 1.0 2.2 -0.6 -0.7 0.9 -1.5
Basal metabolic rate 0.1 0.7 1.7 -0.3 -0.9 -0.5 -1.3
Leg fat percentage (left) 1.6 5.6 9.6 -3.1 1.6 2.6 -1.8
Arm fat-free mass (left) 0.5 2.3 3.7 0.1 -1.5 -1.8 -1.9
Number of operations (self-reported) 0.1 0.2 0.3 0.5 0.4 0.5 -0.4
Average weekly beer plus cider intake 0.2 0.3 0.9 0.9 -0.5 -0.0 -0.3
Irritability 1.4 2.5 5.2 0.7 2.3 2.0 0.3
Risk taking 0.5 0.7 2.6 1.6 0.5 0.0 0.2
Ever had prostate specific antigen (PSA) test 2.7 3.1 6.0 -1.2 2.4 2.0 1.0
Fractured/broken bones in last 5 years 1.6 2.0 3.8 0.6 1.9 1.8 0.8
Age started oral contraceptive pill 0.7 0.9 2.3 -1.5 -0.2 -0.0 1.1
Diastolic blood pressure, automated reading 1.3 4.1 10.2 -3.2 1.0 1.9 1.2
Ever depressed for a whole week 0.3 0.3 1.3 1.1 0.1 -0.1 -0.1
Unable to work because of sickness or disability 2.1 2.8 4.7 1.8 -0.9 -1.5 -2.2
Commuting to job workplace: Cycle 1.4 1.7 5.1 2.3 0.2 -0.6 1.1
Myopia 1.8 2.6 6.5 -2.5 1.2 1.3 0.9
Vascular/heart problems diagnosed by doctor 2.3 6.4 11.0 3.3 -0.6 -2.6 -2.7
Cholesterol lowering medication 2.1 3.1 4.7 -1.4 2.0 2.2 1.3
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.0 -1.3 0.6 1.4 -0.6
Pain experienced in last month 0.6 1.0 3.3 -1.8 -0.7 -0.5 0.3
Supplements: Calcium 2.2 2.4 5.2 -2.3 1.2 1.1 1.3
Basal cell carcinoma (self-reported) 0.1 0.1 0.1 -0.4 -0.2 0.1 -0.3
Heart attack/myocardial infarction (self-reported) 1.3 1.7 4.2 -0.8 1.0 2.0 1.0
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.6 0.3 -1.3 -0.7 -0.5
Heart disease (siblings) 0.3 0.4 0.9 -0.1 -0.8 0.2 -0.9
Alcohol drinker status: Previous 1.3 1.4 1.8 0.9 -1.3 -1.3 -1.2
Pack years of smoking 0.3 0.4 0.7 0.6 0.8 0.4 -0.5
Impedance of whole body 2.2 11.2 23.1 -2.4 3.6 4.8 1.8
Leg fat mass (left) 0.9 3.5 6.4 -2.5 0.7 1.9 -1.8
Arm predicted mass (left) 0.4 1.9 3.7 0.1 -1.4 -1.4 -1.9