Best TWAS P=2.14e-21 · Best GWAS P=4.91e-20 conditioned to 0.00956
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | PPP1R14A | 0.57 | 0.41 | enet | 34 | 0.42 | 1.9e-16 | 9.0 | 9.5 | 2.1e-21 | -0.80 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | PPP1R14A | 0.18 | 0.17 | lasso | 2 | 0.16 | 2.4e-06 | 9.1 | -9.1 | 7.8e-20 | 0.89 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Muscularis | PPP1R14A | 0.38 | 0.31 | enet | 8 | 0.31 | 2.5e-19 | 9.1 | 9.0 | 1.8e-19 | -0.87 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Esophagus Mucosa | PPP1R14A | 0.09 | 0.07 | lasso | 3 | 0.04 | 8.1e-04 | 9.0 | -8.8 | 1.3e-18 | 0.88 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Nerve Tibial | SPINT2 | 0.12 | 0.05 | lasso | 6 | 0.06 | 4.7e-05 | -4.6 | 7.3 | 3.5e-13 | -0.64 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Nerve Tibial | PPP1R14A | 0.09 | 0.06 | lasso | 5 | 0.03 | 3.2e-03 | -9.0 | 6.8 | 1.1e-11 | -0.86 | 0.01 | 0.93 | FALSE |
| 7 | YFS | Blood | PPP1R14A | 0.06 | 0.04 | lasso | 9 | 0.06 | 3.9e-18 | -4.0 | 6.7 | 1.9e-11 | -0.75 | 0.59 | 0.41 | FALSE |