Hub : Genes

SPINT2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2408	0.0962	5.8e-03	0.068	NA	0.211	NA	0.182	1.9e-03	NA	4.2e-08	NA	4.2e-07
2	GTEx	Cells EBV-transformed lymphocytes	0.2770	0.0930	1.3e-03	0.211	NA	0.142	NA	0.177	1.9e-07	NA	2.4e-05	NA	2.1e-06
3	GTEx	Nerve Tibial	0.1239	0.0415	1.2e-04	0.053	NA	0.057	NA	0.060	1.2e-04	NA	7.4e-05	NA	4.7e-05
4	GTEx	Testis	0.2210	0.0820	2.9e-03	0.068	NA	0.063	NA	0.062	6.1e-04	NA	9.2e-04	NA	9.9e-04
5	YFS	Blood	0.0929	0.0234	6.8e-14	0.042	0.054	0.056	0.057	0.058	1.5e-13	3.6e-17	7.7e-18	5.8e-18	1.9e-18
6	TCGA	Prostate Adenocarcinoma	0.1561	0.0567	4.5e-10	0.085	0.108	0.083	NA	0.091	3.1e-09	2.1e-11	4.6e-09	NA	9.1e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.7	4.3	9.9	-0.3	-2.6	3.1	-2.4	0.5	-1.7
Bipolar Disorder or Schizophrenia	0.6	1.6	4.9	-0.2	-1.4	2.2	-0.6	-0.8	-1.2
Depressed Affect (Nagel 2018)	0.3	0.7	2.0	-0.4	0.7	-0.9	0.7	-0.5	1.4
Depression (Nagel 2018)	1.1	1.7	2.5	1.3	-1.2	1.2	1.5	1.6	0.9
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.2	-1.8	0.2	0.6	-1.0	0.2	-1.0
Neuroticism (Nagel 2018)	0.2	0.6	2.1	0.4	0.4	-0.7	0.5	0.5	1.4
Schizophrenia (2018)	0.3	0.6	2.3	-0.3	0.2	0.3	1.1	-1.5	-0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	0.2	0.6	-0.9	-0.5	-0.2	1.1
Worry (Nagel 2018)	0.3	0.7	1.6	0.7	0.4	-0.7	-0.2	1.3	1.1
Alzheimer’s Disease (in mother)	2.4	2.8	5.4	0.2	-2.3	1.8	0.3	1.8	-2.1
Alzheimer’s Disease (in father)	1.3	1.4	4.0	2.0	-1.1	0.7	-0.6	1.2	0.8
Alzheimer’s Disease (including proxy)	2.6	3.7	7.8	1.1	-2.8	2.3	-1.2	1.8	-1.8
Crohns Disease (2017)	0.9	2.1	6.3	-1.0	-1.1	1.9	-0.3	0.6	-2.5
Irritable Bowel Disease (IBD)	0.9	2.2	6.1	-0.8	-1.5	2.5	0.2	-0.3	-2.1
Ulcerative Colitis (UC)	0.6	1.1	3.6	-0.2	-1.4	1.9	0.4	-0.6	-0.8
Major Depression (MDD)	0.3	0.4	1.7	1.3	-0.5	-0.1	0.1	0.1	-0.6
Reaction Time	0.2	0.4	1.3	-0.2	-1.1	0.6	-0.2	0.8	0.1
Verbal and Numeric Reasoning (VNR)	0.4	1.1	2.8	-1.7	0.5	0.6	-1.2	-0.8	-0.9
Breast Cancer	0.6	1.4	2.1	-0.6	1.4	-1.4	0.1	-1.4	1.4
Ovarian Cancer	0.4	0.5	2.2	-0.5	0.2	0.4	0.6	0.3	-1.5
Prostate Cancer	9.3	13.1	52.9	-0.2	-4.8	7.3	-0.9	-1.4	0.0
Age at First Birth	1.5	2.2	5.0	-2.2	1.8	-1.3	-1.4	-1.0	-0.7
Bipolar Disorder (2011)	1.2	1.2	4.2	-1.1	-0.6	1.1	-2.0	-0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.7	1.6	-0.9	0.9	-0.1	0.1	-0.1
Coronary Artery Disease (CAD)	0.6	0.7	2.3	0.4	0.0	-0.4	1.5	0.3	1.2
Crohns Disease (2012)	1.2	2.0	5.4	-0.5	-1.2	1.8	1.0	0.6	-2.3
Mean Putamen Volume	0.5	0.6	1.4	-0.9	0.5	-0.3	-0.4	1.2	-1.0
Fasting Glucose	0.9	1.1	4.2	-0.0	-1.1	0.8	0.5	2.1	-0.3
HbA1C	0.6	0.7	2.5	0.3	0.1	0.3	0.7	-0.8	1.6
HDL Cholesterol	0.4	0.7	1.8	0.7	-1.3	1.3	0.3	0.4	-0.5
LDL Cholesterol	0.3	0.4	1.3	0.1	-1.1	0.6	0.5	-0.0	-0.8
Lupus	2.3	3.5	5.7	-0.8	2.1	-2.4	0.3	-2.3	2.2
Neuroticism (2016)	0.9	1.3	4.7	2.2	-0.8	0.1	0.8	0.9	0.9
Primary Biliary Cirrhosis	0.5	0.7	1.3	-0.8	0.9	-0.1	-1.1	0.1	-1.1
Rheumatoid Arthritis	0.7	0.9	2.2	0.3	0.7	-0.4	-1.4	-1.5	0.7
Schizophrenia (2014)	0.2	0.4	1.9	-0.3	0.5	0.4	0.1	-1.4	-0.1
Triglycerides	0.1	0.2	0.7	0.8	-0.2	-0.3	-0.5	0.3	-0.1
Type 2 Diabetes (T2D) (2012)	1.0	1.1	3.0	0.5	-1.6	1.7	-0.9	0.5	0.2
Ulcerative Colitis	0.4	0.6	1.5	-0.2	-0.7	1.2	0.9	-0.9	0.3
Blood Eosinophil Count	0.5	3.8	13.6	0.9	-1.0	0.8	-3.7	2.5	0.6
Blood Platelet Count	2.4	27.8	84.6	1.8	4.2	-9.2	-4.3	3.1	5.8
Blood Red Count	0.1	1.0	2.3	-1.0	1.0	0.3	1.5	-1.1	-0.7
Blood White Count	0.3	2.2	5.4	-1.2	1.4	-1.6	-0.0	-1.4	2.3
Heel T-Score	0.1	0.7	1.6	0.2	-0.2	0.3	1.2	-1.2	1.1
BMI	0.7	3.9	13.6	1.0	1.2	-1.9	1.3	-1.4	3.7
Height	0.2	3.3	7.0	-2.6	-1.0	1.9	-0.6	0.8	-2.6
Waist Hip Ratio (WHR)	0.2	0.7	2.0	-0.0	1.2	0.2	-0.8	-1.4	-0.0
Systolic Blood Pressure	1.0	4.9	15.4	-3.9	0.5	1.0	-1.1	-1.8	-2.9
Smoking Status	1.1	2.6	7.0	-1.6	1.1	-0.5	-0.2	-2.7	2.1
Allergy or Eczema	1.0	2.5	8.0	-1.3	-0.3	0.1	-1.3	1.8	-2.8
Cardiovascular Disease	0.3	1.0	1.8	-1.3	0.8	-0.8	-1.2	-0.8	0.9
Hypothyroidism (self reported)	0.3	0.6	1.4	-0.8	0.1	-0.5	1.2	1.2	0.4
Respiratory disease	1.6	3.6	10.9	-0.9	0.3	0.7	-3.3	1.3	-2.8
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.4	-1.1	-0.0	0.2	-1.2	-0.2	-0.3
Lung FEV1/FVC ratio	0.4	2.2	6.2	2.2	-1.2	-0.6	-0.6	0.2	2.5
Lung FVC	0.8	4.2	7.7	-1.6	1.9	-2.6	2.8	-2.1	0.1
Neuroticism	0.5	1.3	2.5	-0.3	1.2	-1.6	0.6	0.9	1.6
Chronotype (morning person)	1.7	3.9	9.4	1.9	-3.1	2.7	-0.8	1.4	0.1
Hair Pigment	0.3	9.0	24.6	5.0	-3.1	2.2	2.1	2.0	2.5
Tanning	0.0	0.4	1.9	0.1	0.3	-0.4	1.4	0.6	-0.3
Hand grip strength (left)	0.4	1.1	2.9	-0.4	-1.2	1.7	-0.6	0.8	-1.0
Number of treatments/medications taken	0.6	1.0	2.5	-1.6	1.5	-1.1	-0.1	0.2	0.3
Average weekly spirits intake	0.1	0.1	0.3	0.3	-0.6	0.2	-0.1	-0.3	-0.0
Sensitivity / hurt feelings	0.5	0.9	2.5	0.5	0.9	-1.2	-0.8	0.1	1.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.5	1.2	-0.4	0.9	0.1	0.5	1.0
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.8	-0.4	0.2	-0.2	-0.2	0.8
Relative age of first facial hair	0.2	0.5	2.2	0.2	0.5	-0.6	-1.5	-0.2	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.8	-0.1	-1.1	1.4	-0.9	0.6	0.3
Ever used hormone-replacement therapy (HRT)	1.9	2.4	7.1	2.0	-1.6	2.7	-0.7	-0.4	0.2
Ever had hysterectomy (womb removed)	1.1	1.2	2.6	-0.7	-0.5	1.5	-1.1	-0.7	-1.6
Systolic blood pressure, automated reading	0.6	1.9	3.7	-1.7	0.1	0.8	-1.7	-1.0	-1.9
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	5.9	1.4	-0.6	-0.6	0.4	1.1	2.4
Angina	1.0	1.3	3.8	0.7	0.7	-1.2	-1.2	-0.3	1.9
Medication for hormone replacement therapy	2.8	3.1	6.7	2.6	-2.2	2.3	-0.5	1.2	0.4
Vitamin and mineral supplements	0.2	0.2	0.6	0.5	-0.0	0.3	-0.8	-0.3	-0.6
Supplements: Zinc	0.3	0.4	0.7	-0.9	-0.3	-0.3	0.8	0.8	-0.2
Medication: Co-codamol	1.2	1.4	3.5	-0.5	1.8	-0.9	-0.3	-1.9	0.4
Medication: Metformin	0.3	0.5	1.4	-1.2	0.6	-0.6	-0.6	0.0	-0.3
Diabetes (father)	3.3	4.1	8.9	-3.0	2.7	-1.9	0.2	-1.4	-1.6
Diabetes (mother)	0.2	0.3	0.7	-0.3	0.6	-0.8	-0.7	-0.0	-0.3
Severe depression (siblings)	1.0	1.1	2.4	0.2	-1.3	1.5	1.6	0.6	-0.3
Pack years adult smoking proportion	0.2	0.3	0.9	-0.2	0.4	-0.8	-0.0	0.2	0.9
Impedance of leg (right)	0.2	1.0	3.1	0.0	-0.5	1.4	0.8	-0.4	-1.8
Leg fat-free mass (left)	0.1	0.4	1.9	-0.3	0.0	-0.3	-0.2	-0.4	1.4
Trunk fat percentage	0.2	0.7	3.5	1.9	0.0	0.3	-0.2	-0.5	0.8
Hand grip strength (right)	0.2	0.6	1.4	-0.1	-0.8	1.2	-0.9	0.6	-0.6
Townsend deprivation index at recruitment	0.3	0.4	1.2	-0.7	0.6	0.1	-0.2	-1.1	-0.2
Current tobacco smoking	1.1	1.7	4.6	-1.6	1.1	-1.0	-0.6	-2.1	0.8
Average weekly fortified wine intake	2.6	3.0	7.0	0.9	-2.6	2.6	-1.4	0.4	-1.0
Maternal smoking around birth	1.1	1.7	4.9	-0.9	0.1	1.2	-2.2	-0.9	-1.3
Fed-up feelings	0.9	1.7	2.4	-1.6	1.3	-1.3	1.1	-1.4	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.6	0.5	-0.9	0.7	1.3	1.2	0.9
Relative age voice broke	0.5	0.7	1.4	-1.1	1.2	-1.0	-0.5	-0.4	0.2
Taking other prescription medications	0.3	0.5	1.2	0.5	-0.7	0.4	0.7	1.1	0.5
Age when periods started (menarche)	0.5	1.3	4.0	-0.1	-1.0	1.3	-0.9	0.2	-2.0
Bilateral oophorectomy (both ovaries removed)	3.0	3.4	7.1	1.4	-1.7	2.7	-0.7	2.4	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.7	1.2	-1.1	0.4	0.7	1.3	0.1
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	5.4	-1.9	2.3	-1.8	-0.4	-2.2	-0.4
Qualifications: CSEs or equivalent	1.0	1.3	3.8	1.7	-0.8	-0.0	-0.7	1.9	0.3
Serious illness, injury or assault to yourself	1.0	1.2	2.3	-0.3	1.5	-1.5	-0.2	1.5	-0.8
High blood pressure	0.5	1.5	3.4	-1.8	1.1	-0.6	-1.6	-1.2	0.2
Hayfever, allergic rhinitis or eczema	1.1	2.3	7.6	-1.9	0.1	-0.4	-0.8	1.5	-2.8
Multivitamins +/- minerals	0.4	0.4	1.8	-1.3	0.3	-0.2	-0.1	-0.7	0.5
Stomach or abdominal pain in last month	0.7	0.9	2.4	-1.1	-0.2	0.8	-0.9	0.3	-1.6
Supplements: Glucosamine	0.2	0.2	0.5	0.7	0.2	-0.4	0.4	0.5	0.4
Diverticular disease/diverticulitis (self-reported)	5.1	6.0	18.2	0.6	-2.9	4.3	-2.1	0.5	-2.2
Medication: Atenolol	1.7	2.2	5.2	0.1	1.7	-2.3	1.5	0.8	1.4
Medication: Levothyroxine sodium	0.7	1.2	3.0	-1.7	1.5	-1.4	0.1	-0.1	-0.4
Sitting height	0.2	1.2	4.1	-0.6	-1.5	2.0	0.4	0.0	-0.8
Chronic bronchitis/emphysema (father)	0.8	1.0	2.7	0.2	-1.4	1.6	-1.0	-0.5	-0.1
High blood pressure (mother)	0.9	1.3	3.4	-0.1	-1.6	1.1	-0.6	1.8	-0.2
Body mass index (BMI)	0.5	2.2	8.3	1.9	0.3	-0.8	0.0	-0.7	2.9
Impedance of leg (left)	0.3	1.3	4.6	-0.2	-0.6	1.4	1.0	-0.2	-2.1
Leg predicted mass (left)	0.1	0.4	2.1	-0.3	0.0	-0.3	-0.1	-0.3	1.4
Trunk fat mass	0.2	0.7	1.9	1.4	0.2	0.2	-0.1	-0.9	1.3
Waist circumference	0.4	1.5	4.2	2.0	0.3	0.2	-0.1	-0.8	2.0
Number of incorrect matches in round	0.4	0.7	1.8	-0.6	1.4	-1.0	0.4	-0.2	-0.8
Past tobacco smoking	0.9	1.6	3.8	0.9	-0.4	0.2	-1.1	2.0	-1.9
Alcohol usually taken with meals	0.9	1.5	2.9	1.0	-1.4	1.5	0.3	1.7	-0.5
Nervous feelings	0.6	1.2	2.4	1.4	0.1	-1.0	-0.3	1.6	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.5	0.2	-0.2	0.8	0.8	-0.1	1.2
Hearing difficulty/problems with background noise	0.4	0.6	2.3	0.6	-0.4	0.7	-0.3	0.7	-1.5
Hair/balding pattern: Pattern 2	1.3	1.7	4.6	0.7	-2.2	1.3	-1.6	0.8	-0.3
Had menopause	1.6	2.1	4.1	2.0	-1.7	1.6	-1.0	1.3	-0.0
Had other major operations	0.7	0.8	2.1	0.5	-0.8	1.5	-1.3	-0.4	-0.5
Forced vital capacity (FVC)	0.5	1.9	6.2	-2.5	0.4	-0.2	1.9	-0.8	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.3	1.0	-0.9	0.4	0.7	1.1	0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.6	0.0	0.0	0.2	0.1	0.5
Qualifications: None of the above	0.5	1.1	2.2	0.3	1.3	-1.5	-0.4	-0.7	1.4
Financial difficulties in last 2 years	0.9	1.2	3.4	-0.4	-1.1	1.1	1.1	1.9	-0.1
Mouth/teeth dental problems	0.1	0.1	0.4	-0.6	0.1	-0.0	-0.0	-0.5	-0.4
Heart attack	0.8	1.1	3.2	-0.4	0.6	-1.2	1.8	0.1	1.1
Allergy	1.0	2.4	7.9	1.4	-0.2	0.2	1.4	-1.5	2.8
Pain all over the body in last month	2.3	2.5	10.7	1.5	-0.7	0.1	1.1	-0.6	3.3
Diabetes (self-reported)	0.1	0.2	0.2	-0.4	0.4	-0.5	-0.3	-0.5	0.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.3	-1.7	-0.2	0.7	-1.6	-0.5	-1.8
Medication: Ramipril	0.8	1.0	4.7	-0.3	-0.3	0.3	-2.2	-0.2	0.9
Medication: Simvastatin	0.8	1.2	6.5	-0.7	0.7	-0.0	-2.5	-0.2	0.2
Fluid intelligence score	0.7	1.5	3.3	-1.8	0.5	0.5	-1.2	-0.7	-1.8
Illnesses of siblings	1.2	1.7	2.9	1.6	-1.7	1.3	1.3	1.2	-0.1
Neuroticism score	0.5	1.0	2.2	-0.6	1.2	-1.3	0.3	-0.2	1.5
Weight	0.2	1.0	4.0	1.1	-0.0	0.1	-0.0	-0.9	2.0
Impedance of arm (right)	0.6	2.8	7.2	1.0	-1.2	2.5	0.5	1.0	-2.7
Arm fat percentage (right)	0.5	2.1	7.8	2.8	-0.2	0.4	0.1	-0.3	2.0
Trunk fat-free mass	0.2	0.9	4.1	-0.5	-0.0	-0.5	0.0	-0.8	2.0
Hip circumference	0.1	0.5	1.2	1.1	-0.4	0.4	0.4	-0.1	1.0
Time employed in main current job	1.6	1.8	3.8	1.9	-1.2	-0.0	-1.2	1.9	0.8
Alcohol intake versus 10 years previously	1.0	1.6	3.0	-1.0	1.1	-1.2	0.2	-1.7	1.6
Father’s age at death	0.3	0.5	1.6	-0.6	0.3	0.5	-0.6	-0.4	-1.3
Worrier / anxious feelings	0.9	1.8	5.0	-0.5	1.9	-2.2	0.2	0.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.8	-0.1	1.1	-1.2	-0.4	-0.2	1.7
Falls in the last year	0.9	1.2	4.1	1.3	0.4	-0.7	0.6	0.6	2.0
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	-0.9	0.8	-1.0	-0.2	0.2	-0.6
Number of live births	0.9	1.2	3.2	-0.8	-0.8	1.2	-0.8	0.9	-1.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	5.2	-2.3	0.2	-0.2	1.6	-0.9	-0.4
Pulse rate	0.6	1.0	3.1	1.8	-0.9	0.3	0.5	1.4	-0.1
Happiness	0.1	0.1	0.6	0.3	0.0	-0.0	-0.8	0.2	0.2
Noisy workplace	1.4	1.7	4.6	-0.0	1.5	-2.1	-0.5	-0.4	1.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.9	-0.6	0.6	0.8	1.0	-0.3	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.8	-0.5	-0.5	0.6	0.3	0.8	-1.3
Mouth/teeth dental problems: Dentures	0.6	1.0	2.5	1.6	-0.6	0.9	-0.9	0.4	1.1
Asthma	1.0	1.9	4.8	-1.4	0.9	-0.6	-1.6	1.0	-2.2
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	7.1	-2.7	1.2	-1.6	-0.5	0.6	-1.5
Medication: Cholesterol lowering	1.0	1.5	5.5	-0.3	0.6	-0.8	-2.3	0.8	1.3
Depression (self-reported)	0.9	1.1	2.5	1.1	0.3	-0.5	1.6	-0.1	1.5
Medication: Lansoprazole	0.5	0.5	1.7	0.5	0.4	0.0	0.9	0.6	1.3
Prospective memory result	0.8	1.0	1.9	1.2	0.1	-1.2	-0.1	1.2	1.4
Lung cancer (father)	0.4	0.4	1.8	-1.3	0.5	-0.3	0.5	-0.4	-0.1
Illnesses of mother	0.5	0.6	1.6	0.4	0.4	0.4	1.3	-1.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.3	-1.3	-0.6	0.0	1.8	-0.6	0.0
Pulse wave Arterial Stiffness index	0.4	0.5	1.8	0.5	-0.5	0.7	-1.3	0.5	-0.2
Impedance of arm (left)	0.4	1.9	7.3	0.4	-0.4	1.6	0.4	0.9	-2.7
Arm fat mass (right)	0.4	1.8	5.3	2.2	-0.2	0.1	0.3	-0.5	2.3
Trunk predicted mass	0.1	0.8	3.8	-0.6	-0.1	-0.4	-0.0	-0.8	2.0
Standing height	0.1	1.2	3.2	-1.8	-0.5	1.4	0.2	-0.3	-1.3
Length of working week for main job	1.5	1.7	3.7	1.1	1.2	-0.5	-0.4	-1.9	1.8
Exposure to tobacco smoke at home	0.3	0.3	0.7	0.7	-0.4	0.6	0.5	-0.8	0.3
Breastfed as a baby	1.1	1.3	4.0	1.1	-1.4	0.4	-0.8	2.0	0.2
Tense / ‘highly strung’	0.1	0.2	0.9	-0.7	-0.1	0.3	-0.9	0.1	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.4	-0.9	1.1	-0.9	1.0	-1.0	1.2
Hair/balding pattern: Pattern 4	0.2	0.5	1.9	-0.1	-0.3	-0.5	0.6	0.2	1.4
Birth weight of first child	0.1	0.2	0.5	-0.1	-0.5	0.7	-0.4	0.1	-0.5
Peak expiratory flow (PEF)	0.8	1.8	3.9	-0.4	-1.8	2.0	1.7	-0.1	-0.9
Pulse wave reflection index	0.3	0.3	0.8	-0.2	-0.9	0.9	0.3	-0.6	0.3
Ever highly irritable/argumentative for 2 days	1.4	1.6	2.8	-1.4	1.7	-1.5	-0.3	-1.4	0.9
Loud music exposure frequency	3.6	3.9	9.1	-2.7	3.0	-2.4	1.0	-0.8	0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	3.9	-1.7	0.8	0.2	1.1	1.1	-2.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	0.0	0.6	-0.7	0.6	-0.1	0.1
Blood clot in the leg (DVT)	0.4	0.5	1.4	0.1	-0.1	1.0	0.9	-1.2	0.0
Medication: Paracetamol	0.4	0.6	1.3	-1.1	0.6	-0.8	-0.1	-0.4	1.0
Headache pain in last month	0.3	0.5	0.9	-0.9	0.6	-0.5	-0.8	0.9	-0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.7	-0.5	-0.5	0.4	1.1	-0.3	-1.3
Glaucoma (self-reported)	0.6	0.7	1.4	0.7	-0.5	1.2	-1.2	-0.1	-0.7
Gout (self-reported)	0.2	0.3	1.1	1.0	0.7	-0.1	-0.5	-0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	-0.8	0.0	-0.3	1.0	0.9	0.0
Medication: Amlodipine	1.0	1.4	6.6	-0.7	0.1	0.2	-2.6	-1.1	0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	-0.4	0.4	-0.2	-0.4	-0.7	-0.2
Birth weight	2.6	5.6	13.5	-2.0	3.5	-3.7	-0.8	-1.1	1.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.0	-0.9	1.0	-0.6	-1.0	-0.7	0.5
High blood pressure (siblings)	0.9	1.3	3.0	-1.7	0.7	-0.6	-0.8	0.6	-1.6
Forced vital capacity (FVC), Best measure	0.4	1.5	4.6	-1.9	-0.4	0.0	2.1	-0.4	-0.7
Body fat percentage	0.3	1.1	3.8	1.9	0.3	-0.1	0.1	-0.8	1.5
Leg fat percentage (right)	0.6	2.2	6.5	2.2	0.4	-0.2	0.4	-1.3	2.6
Arm fat-free mass (right)	0.2	1.3	5.1	-0.7	0.4	-1.1	0.1	-0.8	2.2
Exposure to tobacco smoke outside home	0.1	0.2	0.6	-0.4	0.1	-0.2	-0.4	-0.8	0.3
Comparative body size at age 10	0.1	0.3	0.7	-0.4	0.2	-0.3	0.3	-0.8	0.7
Number of full brothers	0.2	0.3	0.8	-0.3	0.2	0.0	0.8	-0.9	-0.3
Worry too long after embarrassment	1.0	1.6	4.1	2.0	-0.3	-0.2	0.6	1.6	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.1	-1.8	1.6	-1.7	0.2	-1.4	0.8
Wheeze or whistling in the chest in last year	0.3	0.6	1.2	-0.0	0.8	-1.1	-1.1	-0.5	0.6
Number of children fathered	0.9	1.0	3.2	-0.9	0.8	-0.6	-1.8	-1.0	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	-0.1	-0.0	-0.1	0.7	0.4	0.6
Age at first live birth	0.4	0.8	3.3	-0.6	-0.1	0.4	0.9	0.1	-1.8
Pulse wave peak to peak time	0.5	0.6	1.8	-0.7	0.6	-0.5	1.4	-0.7	0.1
Health satisfaction	2.4	3.1	9.3	-0.7	2.7	-3.0	-0.5	0.7	0.7
Shortness of breath walking on level ground	1.4	1.7	4.8	1.3	1.1	-1.5	0.1	-0.4	2.2
Qualifications: College or University degree	0.7	2.1	3.6	-1.4	-0.4	1.8	0.4	-1.8	-1.9
Eye problems/disorders: None of the above	0.3	0.3	0.7	-0.5	0.1	-0.7	-0.2	0.8	-0.6
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.8	-1.7	1.6	-1.1	0.8	-0.9	0.2
Emphysema/chronic bronchitis	0.3	0.3	1.2	0.3	-0.6	0.5	-0.1	1.1	0.3
Medication for pain relief, constipation, heartburn	1.3	2.2	4.2	2.1	-1.8	1.9	0.5	0.2	-1.4
Neck or shoulder pain in last month	0.5	0.7	2.1	-1.4	-0.0	0.1	-1.0	0.7	-0.8
Medication: Blood pressure	0.1	0.3	1.0	-0.2	0.4	0.1	-1.0	0.0	0.5
Angina (self-reported)	1.2	1.5	4.3	0.6	0.8	-1.4	-1.3	-0.3	2.1
Migraine (self-reported)	1.0	1.2	2.5	-1.4	1.6	-1.4	-0.2	-0.9	0.2
Medication: Ibuprofen	2.4	2.8	7.7	-2.8	1.9	-2.2	-0.0	0.2	-0.8
Medication: Allopurinol	0.6	0.8	1.9	1.4	-0.3	0.5	-1.3	0.1	0.7
Medication: Omeprazole	0.9	1.1	2.2	-0.3	1.1	-1.3	1.1	-0.4	1.5
Medication: Seretide 50 evohaler	1.5	1.8	4.0	2.0	-0.7	1.7	-1.4	0.8	-0.6
Mean time to correctly identify matches	0.4	0.8	1.5	0.3	-1.2	0.6	-1.2	1.2	-0.1
Heart disease (mother)	1.3	1.6	5.6	2.4	-0.5	0.4	-0.4	-0.6	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	3.2	-0.5	-0.1	0.4	-0.2	0.8	-1.8
Whole body fat mass	0.3	1.1	3.7	1.4	0.3	-0.2	0.3	-0.7	1.9
Leg fat mass (right)	0.4	1.7	6.2	1.6	0.3	-0.2	0.4	-0.9	2.5
Arm predicted mass (right)	0.2	1.2	3.8	-0.7	0.5	-1.1	-0.2	-1.1	1.9
Pulse rate, automated reading	0.4	1.4	4.3	0.9	0.9	-2.1	0.2	0.8	1.3
Alcohol intake frequency.	0.2	0.5	1.7	-0.5	1.3	-0.8	-0.7	-0.2	-0.2
Comparative height size at age 10	0.1	0.6	1.7	-1.3	0.2	0.9	0.0	0.0	-1.1
Number of full sisters	1.1	1.4	3.7	-0.1	-1.4	1.5	-0.3	1.9	-0.3
Suffer from ‘nerves’	0.7	1.2	2.5	1.1	0.3	-0.8	1.2	1.0	1.6
Overall health rating	0.7	1.4	3.6	-1.0	1.7	-1.9	-0.0	0.4	0.9
Chest pain or discomfort	0.2	0.3	1.2	-0.3	0.1	-0.2	-1.1	-0.0	0.6
Had major operations	1.1	1.3	7.0	-0.5	-0.1	0.4	-2.7	-0.2	-0.7
Age at last live birth	1.2	1.7	4.9	-1.2	-0.8	0.8	2.2	0.9	-1.3
Family relationship satisfaction	0.8	1.0	2.3	0.2	-1.3	1.5	-0.0	1.3	-0.4
Leg pain on walking	2.4	3.0	8.1	-1.8	2.9	-2.4	0.0	-1.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.9	0.4	-0.6	0.1	0.6	1.0	0.1
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.1	1.8	-0.9	0.3	0.4	0.4	1.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	0.3	-0.7	-0.1	-0.6	-1.0	-0.1
Medication: Aspirin	0.3	0.4	1.0	-1.0	0.7	-0.2	-0.7	-0.6	0.3
Supplements: Vitamin C	0.6	0.7	2.3	-0.1	0.7	-1.5	0.7	0.1	1.0
Knee pain experienced in last month	0.3	0.4	1.8	-0.2	0.2	0.7	-0.2	-0.1	-1.4
Hypertension (Self-reported)	0.4	1.0	2.2	-1.5	0.9	-0.2	-1.3	-1.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.2	7.7	-0.9	2.8	-1.9	1.4	-1.7	1.5
Illnesses of father: Heart disease	0.7	1.0	2.7	-1.2	0.8	-1.6	1.0	0.6	0.1
Illnesses of siblings: Diabetes	0.3	0.4	0.9	0.2	0.7	-0.9	0.6	-0.4	0.8
Smoking status: Previous	0.7	1.0	2.8	-0.3	0.2	-0.4	1.5	-0.7	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.2	0.5	-0.4	0.2	0.8	-0.2	1.1
Whole body fat-free mass	0.1	0.7	3.1	-0.5	0.1	-0.5	-0.2	-0.7	1.8
Leg fat-free mass (right)	0.0	0.3	1.2	-0.4	-0.0	-0.3	-0.1	-0.1	1.1
Arm fat percentage (left)	0.5	1.8	6.1	2.5	0.3	-0.2	0.4	-0.4	2.1
Average weekly red wine intake	1.0	1.5	2.7	-0.1	-1.3	1.6	-1.2	0.6	-1.6
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.8	-1.2	1.7	-1.0	-0.3	-0.8	-0.5
Mood swings	1.9	3.4	6.3	-2.1	2.5	-2.3	0.3	-1.6	1.2
Loneliness, isolation	0.2	0.3	0.6	-0.6	-0.1	0.6	0.4	-0.8	0.3
Long-standing illness, disability or infirmity	0.6	1.0	3.4	-0.7	0.2	-0.3	1.8	0.9	1.1
Ever had bowel cancer screening	2.6	3.0	5.6	0.3	-1.3	1.9	-2.3	1.3	-2.4
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.5	0.2	-0.2	-0.5	-0.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	-0.6	-0.0	0.2	-0.2	-0.1	-0.4
Friendships satisfaction	1.3	1.6	3.4	1.1	-1.6	1.8	-0.3	1.5	-0.5
Qualifications: nursing, teaching	2.1	3.3	5.9	2.3	-2.4	2.4	-0.6	1.5	-0.1
Commuting to job workplace: Walk	1.1	1.2	3.9	0.8	-1.1	2.0	-0.2	-0.2	-1.1
Eye problems/disorders: Cataract	1.6	1.8	3.7	-1.4	0.6	0.9	-1.6	-1.9	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.3	0.3	-0.5	-0.9	0.8	1.8	-0.3
Medication for cholesterol	0.6	0.9	2.6	0.1	0.6	-1.6	1.0	0.3	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	0.6	-0.3	0.4	0.6	0.1	0.8
Back pain experienced in last month	0.2	0.3	0.7	-0.3	0.6	-0.9	-0.2	0.1	0.6
Mineral and other dietary supplements	0.4	0.5	1.1	-1.0	0.4	0.0	-0.6	-0.5	-1.1
Breast cancer (self-reported)	0.9	1.1	3.8	1.3	-0.6	-0.1	0.4	1.9	0.8
Asthma (self-reported)	1.0	2.0	4.6	-1.4	1.1	-0.6	-1.7	0.9	-2.2
Osteoporosis (self-reported)	0.4	0.5	2.4	0.7	-0.4	1.6	-0.3	-0.2	-0.3
Osteoarthritis (self-reported)	0.7	0.9	2.0	-0.1	1.0	-1.2	1.4	0.3	0.9
Medication: Aspirin	0.6	0.7	1.3	-1.1	1.1	-0.8	-0.7	-0.8	0.5
Medication: Gliclazide	1.1	1.2	3.0	-0.5	-1.7	1.7	-0.6	0.7	-0.7
Illnesses of father: None of the above (group 1)	0.4	0.4	0.9	0.9	-0.9	0.7	0.3	0.6	0.3
Smoking status: Current	1.3	2.0	6.9	-1.4	1.2	-0.9	-0.5	-2.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.1	-0.9	0.1	-1.0	1.0	0.0	-0.3
Whole body water mass	0.1	0.6	3.2	-0.4	-0.0	-0.4	-0.0	-0.6	1.8
Leg predicted mass (right)	0.0	0.3	1.1	-0.5	0.0	-0.4	-0.1	-0.1	1.1
Arm fat mass (left)	0.4	1.7	5.5	2.0	0.2	-0.3	0.5	-0.7	2.4
Number of self-reported non-cancer illnesses	0.6	1.1	3.1	-1.0	1.8	-1.1	-0.4	-0.9	0.6
Average weekly champagne plus white wine intake	1.4	1.9	4.4	-2.1	1.7	-1.1	1.2	-0.5	-1.1
Miserableness	0.4	0.7	2.2	-0.4	0.7	-1.1	0.2	-0.4	1.5
Guilty feelings	0.4	0.7	2.2	-0.3	0.6	-0.7	-0.6	0.6	1.5
Wears glasses or contact lenses	1.4	1.6	3.9	0.2	-0.6	0.9	-2.0	1.2	-1.8
Ever taken oral contraceptive pill	0.4	0.5	1.9	-0.5	-0.6	1.4	0.6	0.2	-0.3
Hearing aid user	0.2	0.2	0.9	0.3	0.1	-0.3	-1.0	0.6	0.0
Mother’s age at death	1.3	1.7	4.9	-1.1	1.8	-2.2	-0.3	-0.9	-0.1
Financial situation satisfaction	1.2	1.5	3.7	-0.4	-1.9	1.1	0.3	1.6	-1.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.2	0.4	-0.5	0.5	0.1	0.0
Commuting to job workplace: Public transport	1.2	1.4	5.3	-2.3	0.8	0.1	0.2	-0.4	-1.5
Eye problems/disorders: Glaucoma	1.3	1.5	3.9	0.7	-1.2	2.0	-1.4	-0.6	-1.0
Medication: Blood pressure	0.5	1.0	3.5	-1.9	1.0	-0.6	-0.3	-1.0	-0.1
Pain type(s) experienced in last month: Hip pain	0.9	1.1	4.3	-0.9	0.8	0.0	-0.4	0.7	-2.1
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.2	1.4	-0.4	-0.5	0.7	1.3	1.8
High cholesterol (Self-reported)	1.0	1.8	4.5	-0.3	1.3	-1.4	-2.1	-0.3	1.6
Medication: Bendroflumethiazide	0.9	1.4	3.8	-1.9	1.5	-0.8	-0.9	-0.7	-0.5
Medication: Paracetamol	0.2	0.2	1.2	-1.1	0.0	-0.2	-0.1	0.4	0.1
Medication: Lisinopril	0.3	0.4	0.7	-0.8	-0.2	0.5	0.8	-0.5	-0.8
Medication: Atorvastatin	2.2	2.7	5.0	-1.4	1.8	-2.2	-2.2	0.7	0.8
Illnesses of father: High blood pressure	1.1	1.3	5.3	-2.3	1.1	-0.4	0.0	-0.7	-1.0
Alcohol drinker status: Never	3.6	4.3	10.1	-0.9	-1.0	1.8	-3.2	1.7	-2.7
Ever smoked	1.0	1.8	3.6	-0.7	0.3	-0.3	1.9	-1.8	1.7
Basal metabolic rate	0.1	0.7	3.3	-0.2	0.0	-0.4	-0.1	-0.7	1.8
Leg fat percentage (left)	0.5	1.7	4.6	1.8	0.4	-0.1	0.2	-1.5	2.1
Arm fat-free mass (left)	0.2	1.0	4.8	-0.1	-0.0	-0.6	0.1	-0.9	2.2
Number of operations (self-reported)	1.4	2.1	7.7	0.5	-1.1	1.8	-2.8	0.1	-0.4
Average weekly beer plus cider intake	0.8	1.2	2.5	-0.7	1.6	-1.3	-0.5	-1.1	1.1
Irritability	1.3	2.1	5.5	-2.3	0.5	1.0	0.3	-1.8	-1.6
Risk taking	0.6	0.9	2.3	1.5	-0.8	0.9	-1.2	-0.1	0.5
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.8	0.9	0.7	-0.1	-0.2	-0.3	-0.3
Fractured/broken bones in last 5 years	0.7	0.9	2.7	-1.6	-0.5	0.5	-0.1	-0.8	-1.2
Age started oral contraceptive pill	0.5	0.6	2.0	0.6	0.6	0.5	-0.7	-1.4	0.5
Diastolic blood pressure, automated reading	0.7	2.0	4.0	0.3	-1.9	2.0	-1.4	0.9	-1.3
Ever depressed for a whole week	0.4	0.4	1.5	-0.5	0.2	-1.2	-0.7	0.1	0.6
Unable to work because of sickness or disability	0.8	1.0	2.8	-0.4	0.9	-1.2	0.7	-0.4	1.7
Commuting to job workplace: Cycle	1.1	1.3	6.7	-0.1	-0.1	-0.0	2.6	-1.0	0.5
Myopia	0.8	1.2	4.2	-1.5	0.6	-0.3	0.0	-0.2	-2.0
Vascular/heart problems diagnosed by doctor	0.5	1.3	1.9	1.3	-1.2	0.8	1.4	1.1	-1.0
Cholesterol lowering medication	0.3	0.5	2.5	-0.2	-0.1	0.5	-1.6	0.4	0.1
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.4	-0.4	1.4	-1.2	0.9	-0.5	1.6
Pain experienced in last month	0.9	1.6	2.3	1.5	-1.5	1.3	1.4	1.0	-0.6
Supplements: Calcium	1.1	1.3	5.1	-0.9	1.1	-0.6	2.3	-0.2	-0.0
Basal cell carcinoma (self-reported)	0.8	0.9	2.4	0.2	-1.5	1.5	0.0	0.9	-0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.9	-0.4	0.3	-0.8	1.7	0.2	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.8	0.0	-0.0	0.9	0.9	-1.3	0.0
Heart disease (siblings)	0.5	0.7	1.3	-1.0	0.9	-0.4	-0.8	-1.2	0.1
Alcohol drinker status: Previous	0.6	0.7	2.5	-0.2	0.4	0.1	1.6	1.1	0.7
Pack years of smoking	0.2	0.3	0.8	-0.4	0.5	-0.9	-0.4	0.2	0.7
Impedance of whole body	0.4	1.8	8.4	-0.2	-0.3	1.4	0.5	0.4	-2.9
Leg fat mass (left)	0.3	1.3	4.9	1.4	0.1	-0.0	0.3	-1.0	2.2
Arm predicted mass (left)	0.2	1.1	5.2	0.0	-0.2	-0.4	-0.2	-1.0	2.3