Hub : Genes

PPP1R14A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.5660	0.0860	3.0e-09	0.409	NA	0.425	NA	0.324	9.8e-16	NA	1.9e-16	NA	4.0e-12
2	GTEx	Esophagus Gastroesophageal Junction	0.1760	0.0750	3.0e-03	0.171	NA	0.141	NA	0.158	8.7e-07	NA	8.4e-06	NA	2.4e-06
3	GTEx	Esophagus Mucosa	0.0900	0.0400	4.2e-03	0.070	NA	0.038	NA	0.042	1.9e-05	NA	1.5e-03	NA	8.1e-04
4	GTEx	Esophagus Muscularis	0.3770	0.0790	2.0e-10	0.307	NA	0.311	NA	0.007	4.6e-19	NA	2.5e-19	NA	1.1e-01
5	GTEx	Nerve Tibial	0.0930	0.0336	5.1e-04	0.056	NA	0.005	NA	0.030	7.5e-05	NA	1.2e-01	NA	3.2e-03
6	GTEx	Whole Blood	0.0920	0.0360	4.4e-03	0.015	NA	0.022	NA	0.012	1.4e-02	NA	4.0e-03	NA	2.4e-02
7	NTR	Blood	0.0742	0.0197	3.3e-10	0.070	0.041	0.063	0.070	0.068	1.4e-21	4.0e-13	1.3e-19	1.7e-21	3.9e-21
8	YFS	Blood	0.0606	0.0153	4.6e-15	0.044	0.055	0.056	0.054	0.057	3.0e-14	1.3e-17	9.0e-18	2.6e-17	3.9e-18
9	TCGA	Breast Invasive Carcinoma	0.0251	0.0124	7.5e-04	0.021	0.008	0.008	NA	0.016	3.0e-05	6.4e-03	6.0e-03	NA	2.4e-04
10	TCGA	Lung Squamous Cell Carcinoma	0.0294	0.0153	2.0e-03	0.014	0.004	0.002	NA	0.011	7.8e-03	9.5e-02	1.6e-01	NA	1.8e-02
11	TCGA	Prostate Adenocarcinoma	0.1299	0.0386	0.0e+00	0.189	0.168	0.172	NA	0.102	2.3e-19	3.0e-17	1.2e-17	NA	8.2e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	3.8	6.0	9.7	3.1	-3.0	-2.6	3.1	1.8	-1.5	-0.8	2.4	2.5	2.2	2.8
Bipolar Disorder or Schizophrenia	1.7	4.1	7.0	2.6	-2.3	-1.6	2.3	1.8	0.5	-0.4	2.6	2.0	2.3	2.4
Depressed Affect (Nagel 2018)	0.4	0.9	2.0	-0.6	1.1	1.3	-1.1	-0.5	1.4	1.2	-1.1	-0.4	-0.4	-0.7
Depression (Nagel 2018)	0.6	0.9	6.1	0.2	-0.5	0.0	0.4	-0.4	-1.3	-2.5	-0.7	-0.6	-0.8	0.6
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.5	2.1	-1.3	-1.5	1.2	0.5	0.1	0.7	1.1	1.7	1.6	1.3
Neuroticism (Nagel 2018)	0.6	1.4	3.4	-0.8	1.1	1.2	-1.2	-1.4	1.4	0.2	-1.8	-1.1	-1.1	-1.0
Schizophrenia (2018)	0.4	0.9	3.2	0.8	-0.5	0.1	0.5	0.9	1.8	0.1	1.5	0.5	1.1	0.8
Schizophrenia vs Biploar Disorder	0.8	1.1	2.4	-1.1	1.2	1.0	-1.3	-0.5	1.6	1.0	-1.0	-0.7	-0.4	-1.1
Worry (Nagel 2018)	0.8	1.7	4.5	-1.5	1.3	1.3	-1.5	-1.5	0.6	0.2	-2.1	-1.1	-1.2	-1.2
Alzheimer’s Disease (in mother)	1.5	1.8	3.6	1.7	-1.7	-1.6	1.9	1.0	-1.0	-1.0	0.7	1.3	0.5	1.6
Alzheimer’s Disease (in father)	0.4	0.4	1.8	-0.3	0.1	-0.2	-0.0	-0.4	-1.3	-0.7	-1.0	-0.4	-0.7	-0.4
Alzheimer’s Disease (including proxy)	1.4	2.0	4.2	1.3	-1.8	-2.0	2.1	0.8	-1.2	-1.1	0.8	1.3	0.5	1.6
Crohns Disease (2017)	2.2	4.8	9.8	2.4	-2.7	-2.4	2.5	1.0	0.6	0.3	2.1	2.8	2.1	3.1
Irritable Bowel Disease (IBD)	3.4	8.1	13.3	3.2	-3.2	-3.0	3.2	1.8	1.4	0.7	2.9	3.5	3.1	3.7
Ulcerative Colitis (UC)	2.1	4.0	6.7	2.6	-2.1	-2.1	2.2	1.5	1.3	0.5	1.9	2.3	2.2	2.3
Major Depression (MDD)	0.5	0.6	3.1	-0.3	0.6	0.8	-0.4	-0.8	1.8	-0.0	0.6	-0.8	-0.4	-0.1
Reaction Time	0.3	0.7	4.1	0.3	-0.4	-0.6	0.5	0.6	-2.0	0.8	-0.7	0.8	0.3	0.4
Verbal and Numeric Reasoning (VNR)	0.9	2.2	4.0	2.0	-1.4	-1.3	1.3	1.3	1.5	0.5	1.8	1.6	1.8	1.4
Breast Cancer	0.4	1.1	3.2	-1.2	1.2	1.0	-1.2	-1.8	-0.4	0.2	-0.7	-1.2	-0.6	-1.0
Ovarian Cancer	1.2	1.6	2.6	1.5	-1.4	-1.4	1.5	1.1	0.3	-1.0	1.4	1.0	1.0	1.6
Prostate Cancer	27.6	38.8	90.2	9.5	-9.1	-8.8	9.0	6.8	-1.8	0.1	6.7	0.0	0.0	0.0
Age at First Birth	0.2	0.3	2.6	-0.8	0.2	0.2	-0.2	-0.2	0.0	1.6	0.1	0.2	-0.1	0.1
Bipolar Disorder (2011)	1.3	1.3	3.8	1.5	-1.4	-1.6	1.5	1.9	-0.0	0.5	1.1	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.5	0.8	0.8	-0.7	-0.4	0.9	0.9	-0.1	-0.9	0.8	0.1	0.4	0.8
Coronary Artery Disease (CAD)	0.2	0.3	1.1	0.0	1.1	0.5	-0.8	-0.1	0.6	0.6	-0.6	0.0	0.0	0.0
Crohns Disease (2012)	1.7	2.7	5.6	2.2	-2.1	-2.0	2.0	1.1	0.7	-0.2	1.7	0.0	1.4	2.4
Mean Putamen Volume	0.4	0.5	2.3	-1.1	0.0	0.2	-0.1	-0.0	-0.2	-1.5	-0.4	-0.7	-1.0	-0.1
Fasting Glucose	0.5	0.6	3.0	-0.2	-0.6	-0.4	0.6	0.0	-1.7	-1.2	-0.9	-0.0	-0.5	0.3
HbA1C	0.5	0.5	1.6	0.5	-0.6	-0.8	0.5	1.3	1.0	0.7	-0.0	0.6	0.7	0.6
HDL Cholesterol	1.1	1.8	4.0	1.3	-1.5	-1.6	1.4	1.5	-0.3	0.7	0.7	2.0	1.4	1.6
LDL Cholesterol	0.2	0.3	0.9	0.2	-0.4	-0.4	0.4	0.8	0.9	0.9	0.5	0.5	0.3	0.3
Lupus	1.9	2.8	5.2	-1.7	2.1	2.1	-2.2	-1.2	1.5	1.9	-0.9	-1.2	-0.4	-2.3
Neuroticism (2016)	0.3	0.5	1.8	-0.7	0.8	1.0	-0.8	-0.4	0.2	0.8	-1.3	-0.1	-0.3	-0.4
Primary Biliary Cirrhosis	0.6	0.8	1.8	0.1	-0.8	-0.4	0.8	1.3	1.3	-0.5	1.0	0.7	0.7	1.3
Rheumatoid Arthritis	0.4	0.6	2.4	0.1	0.0	0.1	-0.1	1.6	0.2	1.5	0.6	0.6	1.0	-0.0
Schizophrenia (2014)	0.7	1.6	4.4	1.3	-1.0	-0.5	0.9	1.3	2.1	0.5	1.6	1.1	1.6	1.3
Triglycerides	0.2	0.3	0.6	-0.4	0.6	0.6	-0.5	-0.2	0.3	-0.0	-0.5	-0.7	-0.8	-0.6
Type 2 Diabetes (T2D) (2012)	1.7	1.9	3.5	1.9	-1.7	-1.5	1.8	1.4	-0.2	-0.2	0.5	1.6	1.4	1.5
Ulcerative Colitis	1.6	2.3	5.5	2.3	-1.4	-1.4	1.5	1.6	1.5	0.9	1.4	0.0	2.0	1.5
Blood Eosinophil Count	0.1	0.7	4.8	-0.9	-0.1	0.2	0.3	0.0	2.2	-0.0	-1.1	0.2	-0.4	0.5
Blood Platelet Count	8.7	100.7	158.8	-12.6	11.6	10.7	-11.8	-8.2	-0.5	4.4	-12.4	-9.3	-10.2	-11.4
Blood Red Count	0.2	2.0	4.0	0.1	-1.2	-1.3	0.9	0.9	1.4	1.8	1.5	2.0	2.0	1.4
Blood White Count	0.2	1.7	3.2	-1.8	1.4	1.6	-1.5	-1.0	1.6	0.7	-1.1	-1.1	-0.3	-1.2
Heel T-Score	0.1	0.6	2.1	1.4	-0.5	-0.5	0.6	0.5	-0.0	0.4	0.8	0.8	1.2	0.2
BMI	1.2	6.9	11.5	-3.0	3.0	3.1	-2.9	-2.1	2.0	-0.9	-1.9	-3.4	-2.1	-3.3
Height	0.2	4.7	8.3	2.4	-2.6	-2.9	2.7	0.3	1.6	-0.3	1.9	2.4	1.7	2.9
Waist Hip Ratio (WHR)	0.3	1.4	2.7	0.9	-1.0	-0.8	0.6	1.6	1.6	0.3	1.5	1.2	1.6	1.2
Systolic Blood Pressure	2.3	11.3	17.1	1.9	-3.2	-3.3	3.2	3.1	4.1	2.1	3.5	4.1	4.0	3.6
Smoking Status	0.4	0.9	5.8	-0.2	0.2	0.2	-0.2	1.6	2.4	-0.5	0.4	-0.4	0.5	-0.5
Allergy or Eczema	0.1	0.3	1.1	0.4	-0.6	-0.5	0.7	-0.3	-0.3	-0.4	-0.1	0.4	-0.6	1.0
Cardiovascular Disease	0.6	1.9	16.6	-1.0	0.9	0.6	-0.8	-0.5	4.1	-0.2	-0.0	-0.8	0.1	-0.6
Hypothyroidism (self reported)	0.8	1.8	3.8	-0.5	0.9	1.2	-0.8	-1.7	-0.1	-1.9	-1.4	-1.8	-2.0	-1.0
Respiratory disease	0.9	2.0	4.8	0.7	-1.7	-1.5	1.6	1.9	-0.5	0.3	1.2	1.8	0.7	2.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.9	0.8	-0.5	-0.4	0.5	0.9	1.4	0.9	0.4	0.9	0.9	0.8
Lung FEV1/FVC ratio	0.9	4.6	8.8	-2.7	2.5	2.5	-2.0	-1.6	-0.0	-1.3	-2.0	-3.0	-2.1	-2.3
Lung FVC	0.7	3.6	6.2	-1.9	2.5	2.5	-2.3	-1.9	0.9	0.9	-0.8	-2.1	-1.5	-2.4
Neuroticism	1.0	2.4	5.9	-0.4	1.7	1.7	-1.9	-1.1	1.9	0.6	-2.4	-1.3	-1.4	-1.6
Chronotype (morning person)	1.2	2.8	6.7	1.7	-2.0	-1.9	2.0	0.1	-2.6	0.0	0.8	2.0	1.6	1.7
Hair Pigment	0.0	1.0	9.2	0.2	-0.0	0.1	0.1	-0.5	-3.0	-0.6	-1.2	0.3	-0.1	-0.3
Tanning	0.0	0.4	1.8	0.2	0.5	0.6	-0.5	-0.4	-1.3	0.3	-0.4	-0.7	-0.8	-0.6
Hand grip strength (left)	0.9	2.2	5.1	1.2	-2.0	-2.3	2.0	1.0	-1.0	-0.8	0.8	1.6	1.1	1.7
Number of treatments/medications taken	0.8	1.4	5.7	-0.4	1.0	1.4	-1.0	-1.0	2.4	-0.9	-0.5	-1.3	-0.8	-0.9
Average weekly spirits intake	0.7	0.9	3.0	0.6	-0.6	-0.4	0.7	1.1	0.6	1.7	0.4	1.4	1.3	0.6
Sensitivity / hurt feelings	0.9	1.6	3.8	-0.9	1.5	1.3	-1.5	-1.2	0.8	0.8	-2.0	-1.0	-0.8	-1.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	6.4	0.1	-0.4	-0.1	0.4	-0.1	-0.7	-2.5	0.1	-0.8	-0.2	0.5
Hearing difficulty/problems: Yes	0.3	0.4	2.8	-0.4	0.2	0.3	-0.1	-0.5	0.1	-1.7	-0.1	-0.8	-0.5	-0.3
Relative age of first facial hair	0.1	0.2	0.5	-0.7	0.4	0.4	-0.3	-0.1	-0.5	-0.7	0.0	-0.6	-0.6	-0.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	1.9	1.0	-1.4	-1.2	1.4	0.5	0.9	-1.2	0.5	0.9	0.9	1.4
Ever used hormone-replacement therapy (HRT)	2.9	3.7	6.3	2.0	-2.5	-2.3	2.3	1.5	-0.8	-1.3	1.8	1.9	2.1	1.9
Ever had hysterectomy (womb removed)	3.2	3.6	6.2	1.6	-2.0	-1.9	1.9	2.1	1.3	-0.2	2.5	2.0	2.3	2.1
Systolic blood pressure, automated reading	1.3	3.9	6.6	0.9	-1.8	-1.9	1.9	1.5	2.6	1.1	2.4	2.3	2.3	2.2
Eye problems/disorders: Diabetes related eye disease	2.5	2.8	4.6	-1.2	1.7	2.0	-1.7	-1.8	0.1	-0.7	-2.1	-2.1	-1.8	-1.7
Angina	2.1	2.8	4.6	-2.1	1.9	1.8	-2.1	-1.6	0.3	1.5	-1.7	-1.1	-0.9	-2.2
Medication for hormone replacement therapy	1.3	1.4	2.4	1.2	-1.6	-1.5	1.4	1.1	-1.5	-1.1	0.3	0.9	1.0	1.1
Vitamin and mineral supplements	0.3	0.4	0.8	0.1	-0.7	-0.7	0.7	-0.2	0.8	0.3	0.7	0.8	0.8	0.9
Supplements: Zinc	0.2	0.2	0.8	0.3	-0.1	0.1	0.2	-0.2	0.7	-0.9	-0.5	-0.2	-0.6	-0.1
Medication: Co-codamol	0.6	0.7	5.1	-0.8	0.3	0.1	-0.3	0.8	2.3	0.8	0.8	0.1	0.5	-0.2
Medication: Metformin	0.2	0.3	1.9	-0.4	0.3	0.4	-0.3	0.2	1.4	1.0	-0.1	0.1	0.0	0.0
Diabetes (father)	0.5	0.6	1.5	-0.4	0.8	0.9	-0.7	-1.2	1.0	0.6	0.8	-0.6	-0.6	-0.2
Diabetes (mother)	1.2	1.5	2.5	-1.6	1.3	1.3	-1.1	-1.3	0.5	-0.6	-0.4	-1.6	-1.5	-1.4
Severe depression (siblings)	1.0	1.1	3.1	1.3	-1.2	-1.0	1.1	0.2	-1.5	-1.8	0.4	0.4	0.1	0.9
Pack years adult smoking proportion	0.5	0.8	4.5	-0.6	0.7	0.9	-0.7	-0.8	2.1	0.7	-0.9	-0.3	-0.4	-0.6
Impedance of leg (right)	0.9	4.3	7.0	2.0	-2.4	-2.3	2.3	2.2	0.3	0.4	1.9	2.6	2.3	2.6
Leg fat-free mass (left)	0.2	1.1	2.0	-1.0	1.0	0.8	-0.9	-1.4	1.2	-0.7	-0.7	-1.4	-0.9	-1.3
Trunk fat percentage	0.2	1.0	4.1	-2.0	0.3	0.4	-0.4	-0.5	1.6	-1.5	0.3	-0.9	-0.3	-0.4
Hand grip strength (right)	0.4	1.1	2.9	0.4	-1.4	-1.7	1.4	0.8	-0.7	-0.4	0.5	1.2	1.0	1.0
Townsend deprivation index at recruitment	0.4	0.6	1.7	1.3	-0.6	-0.6	0.6	0.9	1.2	-0.1	0.8	0.5	0.7	0.6
Current tobacco smoking	0.5	0.8	7.7	-0.4	0.5	0.6	-0.5	0.3	2.8	-0.2	0.2	-0.5	0.2	-0.5
Average weekly fortified wine intake	3.4	4.0	6.0	2.0	-2.4	-1.9	2.5	1.9	-1.6	0.0	1.5	2.4	2.2	2.2
Maternal smoking around birth	1.7	2.4	4.9	1.5	-1.8	-1.9	1.7	0.9	0.4	-0.7	2.2	1.4	1.6	1.9
Fed-up feelings	0.4	0.7	2.6	-0.1	0.9	1.0	-0.9	-1.0	1.6	0.6	-0.3	-0.6	-0.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	3.8	0.5	-0.3	0.1	0.4	-0.4	-1.0	-1.9	-1.0	-0.5	-0.7	0.2
Relative age voice broke	0.1	0.1	0.6	-0.8	0.3	0.4	-0.2	0.2	0.3	0.6	-0.1	-0.1	0.0	-0.4
Taking other prescription medications	0.5	0.8	3.8	0.1	0.3	0.6	-0.2	-0.8	2.0	-1.5	-0.5	-0.9	-0.4	-0.4
Age when periods started (menarche)	0.9	2.2	3.6	1.2	-1.8	-1.8	1.9	1.2	-1.2	-1.8	1.6	0.9	0.8	1.5
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	6.2	1.7	-2.4	-2.5	2.1	0.3	-1.5	-2.4	1.0	1.4	0.7	2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.3	-0.3	0.3	0.1	-0.1	0.1	-0.9	1.2	-0.9	0.3	-0.4	-0.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.0	-1.0	0.8	0.8	-0.8	-0.3	0.9	0.0	0.6	-1.0	-0.3	-0.7
Qualifications: CSEs or equivalent	1.3	1.7	3.5	-1.3	1.1	1.0	-0.8	-1.4	-1.1	-0.7	-1.7	-1.4	-1.9	-1.2
Serious illness, injury or assault to yourself	2.7	3.3	6.2	-2.0	1.7	1.8	-1.7	-2.4	1.2	-1.4	-1.4	-2.2	-2.5	-1.4
High blood pressure	0.4	1.1	10.3	-0.1	0.2	-0.0	-0.1	0.1	3.2	-0.4	0.7	-0.3	0.7	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.8	0.2	-0.3	-0.3	0.5	-0.2	0.9	0.3	0.0	0.5	-0.4	0.8
Multivitamins +/- minerals	0.2	0.2	1.2	0.3	0.2	-0.0	-0.2	0.1	-0.4	-1.1	0.2	-0.7	-0.4	-0.5
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.1	-0.7	-0.7	0.8	-0.2	-0.2	-1.0	0.9	0.3	0.2	0.8
Supplements: Glucosamine	0.8	1.0	2.6	-0.1	1.1	0.9	-1.1	0.2	-1.6	0.2	-0.9	-1.1	-1.0	-1.3
Diverticular disease/diverticulitis (self-reported)	13.4	16.0	24.2	3.8	-4.8	-4.9	4.9	3.8	-1.5	-0.3	3.5	4.7	4.1	4.7
Medication: Atenolol	4.0	5.0	7.9	-2.2	2.7	2.6	-2.8	-2.1	0.8	0.5	-2.4	-2.4	-2.1	-2.6
Medication: Levothyroxine sodium	0.6	1.0	1.8	-0.9	1.0	1.1	-1.0	-0.9	1.4	-0.6	-0.5	-1.1	-1.2	-0.8
Sitting height	0.4	3.0	5.6	1.7	-2.2	-2.4	2.2	0.6	1.2	-0.5	1.6	1.9	1.9	1.9
Chronic bronchitis/emphysema (father)	2.5	3.0	5.8	1.8	-1.9	-1.8	1.8	1.6	-1.4	1.0	1.0	2.4	2.0	1.8
High blood pressure (mother)	0.4	0.5	4.2	-0.4	-0.2	0.0	0.4	-0.8	0.2	-2.0	-0.3	-0.6	-0.5	0.3
Body mass index (BMI)	1.0	4.4	8.1	-2.7	2.1	2.1	-2.0	-2.3	1.0	-1.6	-1.3	-2.8	-1.8	-2.5
Impedance of leg (left)	0.9	4.3	6.7	1.9	-2.4	-2.3	2.4	2.4	0.5	0.2	1.9	2.6	2.1	2.6
Leg predicted mass (left)	0.2	1.3	2.2	-1.1	1.1	0.9	-1.0	-1.5	1.2	-0.7	-0.8	-1.5	-1.0	-1.4
Trunk fat mass	0.3	1.2	3.5	-1.9	0.5	0.6	-0.5	-0.9	1.7	-1.5	0.2	-1.2	-0.4	-0.8
Waist circumference	0.2	0.9	2.9	-0.9	0.5	0.6	-0.6	-1.1	1.2	-1.7	0.1	-1.2	-0.2	-0.8
Number of incorrect matches in round	0.7	1.1	8.2	-0.8	0.3	0.0	-0.5	0.9	1.0	2.9	-0.2	0.9	0.5	0.2
Past tobacco smoking	0.3	0.6	2.9	-0.6	-0.2	0.0	0.1	-1.7	-1.4	-0.1	-0.5	0.2	-0.7	0.4
Alcohol usually taken with meals	0.8	1.4	4.5	1.5	-1.2	-1.0	1.2	1.4	-2.1	-0.4	0.1	1.0	0.5	1.1
Nervous feelings	0.8	1.5	6.1	-1.3	1.2	1.1	-1.4	-0.8	0.2	0.5	-2.5	-0.9	-1.2	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.2	1.5	-1.1	-0.7	1.0	1.1	-0.2	-0.9	0.3	0.6	0.9	1.1
Hearing difficulty/problems with background noise	0.1	0.2	0.7	0.3	-0.3	-0.3	0.2	-0.4	-0.7	-0.9	0.1	-0.1	-0.6	0.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.2	1.1	-0.8	-0.9	1.0	0.4	-0.4	0.5	-0.0	1.1	0.9	0.7
Had menopause	0.3	0.4	1.8	0.4	-0.7	-0.6	0.7	0.2	-0.9	-1.3	-0.0	0.1	0.0	0.5
Had other major operations	1.1	1.4	2.9	1.2	-1.2	-1.0	1.3	1.4	1.0	-0.9	1.7	0.7	1.2	1.0
Forced vital capacity (FVC)	0.1	0.3	1.0	0.7	-0.0	0.1	0.2	-0.3	1.0	-1.0	0.5	-0.5	-0.1	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.8	-0.1	0.1	0.1	0.0	0.1	-0.9	0.2	-0.6	-0.0	-0.5	-0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	0.6	-0.5	-0.8	0.5	-0.7	0.9	0.1	-0.1	0.6	0.6	0.4
Qualifications: None of the above	0.5	1.0	1.7	-1.2	1.2	1.3	-1.3	-1.0	0.7	-0.1	-0.7	-1.1	-0.8	-1.0
Financial difficulties in last 2 years	0.7	0.9	4.0	1.5	-0.8	-0.9	1.0	-0.6	-0.2	-2.0	-0.4	0.0	-0.5	0.6
Mouth/teeth dental problems	0.2	0.3	0.6	0.6	-0.3	-0.2	0.3	0.7	-0.6	0.8	0.7	0.6	0.4	0.4
Heart attack	2.0	2.6	4.1	-0.9	2.0	1.9	-1.9	-2.0	0.3	0.1	-1.6	-1.9	-1.4	-2.0
Allergy	0.1	0.3	1.1	-0.4	0.6	0.4	-0.7	-0.5	-0.7	-0.0	-0.3	-0.6	0.3	-1.0
Pain all over the body in last month	0.7	0.8	1.4	-0.4	1.0	1.0	-0.8	-1.2	0.8	0.0	-1.2	-0.9	-0.5	-1.1
Diabetes (self-reported)	0.3	0.5	4.2	0.2	0.5	0.4	-0.3	0.4	2.0	0.7	0.1	-0.2	0.1	0.0
Hayfever/allergic rhinitis (self-reported)	1.8	2.3	4.1	2.0	-1.5	-1.3	1.6	1.8	0.8	0.1	1.8	1.6	1.6	1.7
Medication: Ramipril	0.1	0.1	0.6	-0.3	-0.2	-0.2	0.1	-0.1	0.2	0.0	0.0	0.4	0.8	0.3
Medication: Simvastatin	0.1	0.2	0.7	0.3	-0.2	-0.1	0.2	0.4	0.2	0.8	0.3	0.6	0.7	0.4
Fluid intelligence score	0.7	1.4	3.1	1.5	-1.1	-1.0	1.0	1.2	1.1	0.4	1.8	1.2	1.3	1.1
Illnesses of siblings	0.4	0.5	3.9	0.7	-0.5	-0.7	0.5	-0.2	-2.0	-0.5	-0.2	0.2	-0.1	0.2
Neuroticism score	0.7	1.5	6.2	-0.4	1.1	1.1	-1.2	-1.1	2.5	0.2	-1.5	-0.9	-0.6	-1.1
Weight	0.3	1.6	3.0	-1.5	1.0	0.9	-0.9	-1.6	1.2	-1.5	-0.3	-1.7	-0.8	-1.4
Impedance of arm (right)	1.7	8.0	15.3	2.3	-3.5	-3.3	3.2	2.7	-0.2	-0.0	2.5	3.6	2.7	3.9
Arm fat percentage (right)	0.4	1.7	4.2	-2.0	0.8	0.9	-0.9	-1.5	0.8	-1.9	-0.3	-1.7	-0.9	-1.1
Trunk fat-free mass	0.3	1.8	3.9	-0.7	1.5	1.3	-1.3	-1.9	0.6	-0.6	-1.1	-1.9	-1.1	-2.0
Hip circumference	0.2	1.1	5.0	-0.7	0.2	0.4	-0.2	-1.4	1.2	-2.2	0.1	-1.3	-0.7	-0.6
Time employed in main current job	1.5	1.7	4.9	-0.9	1.0	1.2	-1.1	0.6	-2.2	-0.1	-2.1	-1.0	-1.5	-1.3
Alcohol intake versus 10 years previously	0.8	1.2	3.0	-1.3	1.3	1.2	-1.4	-0.6	-0.0	1.7	-1.0	-0.6	-0.4	-1.3
Father’s age at death	1.2	1.6	3.4	0.7	-1.2	-1.1	1.0	1.5	0.3	1.5	1.3	1.9	1.6	1.2
Worrier / anxious feelings	1.9	3.6	5.7	-2.2	2.2	1.9	-2.4	-2.0	1.3	0.5	-2.3	-1.7	-1.6	-2.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.7	-0.8	1.4	1.6	-1.5	-1.2	0.5	0.4	-1.6	-1.2	-0.9	-1.6
Falls in the last year	2.4	3.2	5.3	-2.3	1.6	1.6	-1.7	-2.3	-0.2	-1.4	-1.9	-2.1	-1.7	-2.0
Hair/balding pattern: Pattern 3	0.5	0.7	2.0	-1.4	0.8	1.1	-0.8	-0.7	0.5	0.9	-0.6	-0.4	-0.7	-0.7
Number of live births	1.0	1.5	6.5	1.1	-1.2	-0.8	1.4	-0.5	0.7	-2.6	1.4	0.1	0.2	1.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.1	0.7	0.0	0.2	0.2	-0.4	1.0	-1.0	0.4	-0.5	0.0	0.1
Pulse rate	0.4	0.7	2.8	-1.7	0.8	0.2	-0.7	-0.4	-0.4	0.6	-1.4	-0.3	-0.9	-0.7
Happiness	0.2	0.3	0.9	-0.0	-0.3	-0.4	0.2	0.2	0.9	0.9	0.0	0.6	0.5	0.5
Noisy workplace	3.6	4.4	10.8	-3.3	2.4	2.2	-2.4	-2.2	0.3	0.4	-2.1	-2.1	-1.9	-2.1
Qualifications: A levels/AS levels or equivalent	0.9	2.0	5.8	2.4	-1.5	-1.5	1.5	1.7	-1.0	-0.9	1.5	0.8	0.9	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.4	-0.4	-0.3	0.5	-0.2	-0.6	-0.3	0.3	0.1	-0.2	0.5
Mouth/teeth dental problems: Dentures	0.1	0.1	0.6	0.4	-0.3	-0.3	0.1	0.0	-0.6	-0.8	0.0	-0.1	0.3	0.0
Asthma	0.1	0.2	1.0	0.1	-0.2	0.2	0.1	1.0	-0.9	0.4	0.2	0.3	-0.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.9	-0.7	1.0	0.9	-1.0	-0.8	-0.6	0.9	-0.7	-0.5	-0.9	-0.5
Medication: Cholesterol lowering	0.9	1.4	4.0	-1.4	1.0	0.7	-1.1	-1.0	1.1	2.0	-1.7	-0.1	-0.6	-1.1
Depression (self-reported)	0.8	0.9	2.2	0.2	1.0	1.1	-0.9	-0.9	0.9	-1.1	-0.5	-1.5	-0.9	-0.8
Medication: Lansoprazole	0.5	0.6	1.4	-0.7	0.4	0.5	-0.5	-1.1	0.6	-1.2	-0.9	-0.9	-0.7	-0.3
Prospective memory result	5.1	6.3	8.7	-2.6	2.8	2.6	-2.7	-2.9	-0.1	-0.4	-2.9	-2.9	-2.8	-2.7
Lung cancer (father)	0.2	0.3	0.7	-0.4	0.5	0.4	-0.5	-0.1	0.6	-0.8	-0.1	-0.9	-0.6	-0.3
Illnesses of mother	0.9	1.1	2.1	1.4	-0.9	-1.2	0.8	0.4	0.6	1.0	1.2	1.3	1.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.2	0.6	0.4	0.6	-0.1	-0.9	0.8	-1.8	0.0	-1.3	-0.7	-0.5
Pulse wave Arterial Stiffness index	1.1	1.3	4.7	0.7	-0.9	-0.9	0.7	0.3	0.6	2.2	0.2	1.9	1.3	1.0
Impedance of arm (left)	1.2	5.7	11.5	1.5	-2.9	-2.6	2.6	2.6	0.7	0.2	2.2	3.1	2.3	3.4
Arm fat mass (right)	0.6	2.7	5.0	-2.1	1.3	1.3	-1.2	-2.0	1.1	-2.2	-0.6	-2.2	-1.3	-1.7
Trunk predicted mass	0.3	1.7	3.6	-0.6	1.4	1.2	-1.2	-1.9	0.6	-0.6	-1.1	-1.8	-1.1	-1.9
Standing height	0.2	2.4	3.9	1.8	-1.8	-2.0	1.8	0.8	1.1	-0.0	1.5	1.7	1.6	1.7
Length of working week for main job	1.0	1.1	2.8	-0.5	1.2	1.1	-1.3	-0.7	1.0	-1.2	0.7	-1.7	-0.3	-1.0
Exposure to tobacco smoke at home	0.5	0.6	4.5	0.4	-0.2	-0.1	0.1	-0.0	-2.1	-1.2	0.4	-0.4	-0.0	-0.2
Breastfed as a baby	0.9	1.1	2.0	-0.9	0.8	0.6	-0.6	-1.3	-0.6	-1.3	-1.4	-1.3	-1.4	-0.9
Tense / ‘highly strung’	0.4	0.7	1.7	1.3	-0.8	-0.7	0.6	0.9	0.9	0.1	0.4	1.0	1.1	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.7	0.4	0.5	-0.3	-0.2	0.8	-0.5	-0.2	-0.6	0.3	-0.6
Hair/balding pattern: Pattern 4	0.2	0.5	2.0	-0.1	0.5	0.1	-0.5	0.1	-0.9	1.2	-1.4	-0.0	-0.3	-0.8
Birth weight of first child	0.3	0.6	1.1	0.5	-1.0	-1.1	0.8	0.1	0.7	0.3	0.8	0.9	1.0	0.9
Peak expiratory flow (PEF)	1.3	3.0	5.3	2.3	-2.0	-2.0	2.3	1.2	0.5	-0.8	1.4	1.6	1.7	2.1
Pulse wave reflection index	2.0	2.4	5.5	1.9	-1.5	-1.1	1.5	0.9	-0.4	2.0	0.9	2.3	2.1	1.5
Ever highly irritable/argumentative for 2 days	1.3	1.5	6.7	-1.3	0.9	1.0	-0.9	-1.5	2.6	-0.9	-0.1	-1.3	-0.5	-1.0
Loud music exposure frequency	0.8	0.9	2.2	-1.4	1.2	1.1	-1.5	-0.1	0.4	1.1	-0.3	-0.6	-0.5	-0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.7	1.9	-1.0	-1.0	0.9	0.6	-0.6	-0.0	0.6	0.8	0.3	0.9
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.4	-0.8	0.7	0.6	-0.7	-1.6	1.0	0.2	-0.9	-0.5	-0.6	-0.8
Blood clot in the leg (DVT)	0.8	1.0	2.5	0.9	-1.1	-0.9	1.1	0.1	0.4	-1.6	1.6	0.4	1.1	0.7
Medication: Paracetamol	0.9	1.4	2.9	-1.0	0.9	1.3	-0.9	-0.9	1.7	-1.7	-0.4	-1.6	-0.9	-1.1
Headache pain in last month	1.4	2.5	6.9	-1.3	0.9	1.0	-0.9	-2.0	-0.4	-2.6	-1.3	-2.0	-2.1	-1.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.3	1.0	-0.9	-0.7	1.0	1.1	-0.3	-0.5	1.0	0.6	0.4	1.0
Glaucoma (self-reported)	1.3	1.6	2.3	0.8	-1.5	-1.4	1.5	1.2	-0.7	0.3	1.3	1.5	1.4	1.4
Gout (self-reported)	0.9	1.2	4.2	-2.1	0.9	1.0	-1.1	-0.9	1.8	-0.1	-0.0	-1.0	-0.6	-0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.6	-0.0	0.5	0.7	-0.4	-0.9	0.7	-1.6	-0.7	-1.1	-1.3	-0.5
Medication: Amlodipine	0.3	0.5	1.9	0.8	-0.3	-0.3	0.1	1.4	0.6	0.5	0.7	0.4	0.9	0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.5	0.1	0.1	0.4	-0.0	0.7	0.3	0.0	0.5	-0.1	0.2	0.3
Birth weight	3.1	6.7	12.2	-2.6	3.4	3.3	-3.5	-1.4	2.3	1.4	-1.6	-2.7	-2.2	-2.9
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	-0.7	0.2	0.1	-0.3	-0.1	0.4	0.2	0.1	-0.2	-0.0	-0.2
High blood pressure (siblings)	0.2	0.3	2.3	-0.4	-0.3	-0.0	0.2	0.1	1.5	-0.1	0.6	0.2	-0.0	0.5
Forced vital capacity (FVC), Best measure	0.1	0.4	1.6	0.9	0.1	0.2	0.2	-0.7	0.6	-1.2	0.2	-0.7	-0.5	-0.0
Body fat percentage	0.4	1.5	5.4	-2.3	0.8	0.9	-0.9	-1.0	1.4	-1.5	-0.1	-1.5	-0.7	-1.0
Leg fat percentage (right)	0.5	1.7	3.9	-2.0	1.1	1.2	-1.1	-1.1	1.2	-1.3	-0.4	-1.7	-0.7	-1.5
Arm fat-free mass (right)	0.7	3.7	6.9	-1.8	2.1	1.9	-1.9	-2.2	1.0	-0.8	-1.6	-2.6	-1.7	-2.6
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.2	0.4	0.2	-0.3	0.2	0.0	0.0	-0.2	-0.5	-0.1	-0.4
Comparative body size at age 10	0.1	0.2	1.6	0.2	0.1	0.2	0.0	0.1	1.3	0.5	0.0	0.0	0.3	-0.2
Number of full brothers	0.3	0.3	1.5	-0.5	0.2	0.4	-0.1	0.5	1.2	-0.8	0.4	-0.6	-0.1	-0.0
Worry too long after embarrassment	1.1	1.8	6.2	-0.8	1.2	1.0	-1.3	-1.1	0.2	-0.8	-2.5	-1.5	-1.5	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.9	0.1	0.8	1.1	-0.7	-0.1	1.4	-0.1	0.2	-0.8	0.1	-0.8
Wheeze or whistling in the chest in last year	0.5	1.0	4.1	-1.0	1.0	1.1	-1.1	-0.1	2.0	1.1	-0.4	-0.4	-0.2	-0.7
Number of children fathered	0.6	0.7	2.0	-0.3	0.4	0.4	-0.2	-1.3	1.1	-1.4	0.5	-1.0	-0.7	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.3	-0.0	0.1	-0.0	0.4	-0.5	0.8	-0.8	0.3	0.1	-0.4
Age at first live birth	0.6	1.0	2.2	0.7	-1.2	-0.8	1.2	1.1	-0.4	-0.6	1.3	0.9	0.7	1.5
Pulse wave peak to peak time	0.8	0.9	5.1	-0.4	0.6	0.6	-0.4	-0.0	-0.3	-2.3	0.3	-1.6	-0.9	-0.6
Health satisfaction	6.0	7.8	11.2	-3.3	3.2	3.2	-3.3	-2.7	1.8	0.0	-2.3	-3.2	-3.0	-3.1
Shortness of breath walking on level ground	3.4	4.1	8.3	-1.4	2.2	2.3	-2.5	-1.8	-0.0	-1.4	-1.6	-2.9	-1.9	-2.5
Qualifications: College or University degree	1.7	5.4	11.8	2.9	-2.4	-2.3	2.6	2.1	0.9	-1.6	3.4	1.6	2.3	2.4
Eye problems/disorders: None of the above	0.7	0.9	1.4	-0.9	1.0	0.7	-0.9	-1.0	-0.8	1.1	-1.1	-0.6	-1.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.4	0.2	-0.1	0.0	0.0	0.2	1.5	1.5	0.2	0.8	0.8	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.7	-0.4	-0.0	0.1	-0.1	-0.2	0.1	-0.1	-0.9	0.1	-0.5	-0.1
Medication for pain relief, constipation, heartburn	1.1	1.9	4.6	1.3	-1.6	-1.8	1.8	0.5	-2.1	-0.7	1.3	1.1	0.7	1.4
Neck or shoulder pain in last month	0.6	0.9	5.3	0.0	0.1	0.4	0.1	-1.5	-0.2	-2.3	-0.2	-1.0	-1.1	-0.3
Medication: Blood pressure	0.1	0.1	0.5	-0.1	0.1	0.0	-0.1	-0.6	0.1	-0.7	0.1	-0.3	0.1	-0.1
Angina (self-reported)	2.6	3.4	5.7	-2.2	2.1	2.0	-2.4	-1.7	0.4	1.6	-2.0	-1.3	-1.1	-2.4
Migraine (self-reported)	1.6	2.0	4.7	-0.9	1.6	1.7	-1.6	-0.5	0.4	-1.4	-0.7	-2.2	-1.6	-1.6
Medication: Ibuprofen	1.1	1.3	2.2	-1.3	1.5	1.4	-1.5	-1.1	0.1	0.2	-0.9	-1.3	-1.4	-1.0
Medication: Allopurinol	0.4	0.5	2.2	-1.4	0.3	0.4	-0.3	-0.7	1.5	-0.5	-0.1	-0.5	-0.3	-0.3
Medication: Omeprazole	1.0	1.2	5.1	-1.0	1.1	1.3	-1.2	-0.5	2.3	0.9	-0.9	-0.6	-0.1	-1.0
Medication: Seretide 50 evohaler	0.7	0.8	1.7	0.8	-1.2	-1.3	1.0	0.7	-0.6	-0.6	0.7	0.8	0.8	1.1
Mean time to correctly identify matches	0.4	0.7	5.8	0.1	-0.2	-0.3	0.2	0.1	-2.4	0.8	-0.7	0.6	0.1	0.4
Heart disease (mother)	0.2	0.2	0.5	-0.7	0.5	0.6	-0.5	0.2	-0.4	-0.2	-0.5	-0.5	-0.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	1.0	-1.0	-1.0	1.1	0.9	-0.1	-0.3	0.5	0.8	0.4	1.1
Whole body fat mass	0.5	2.3	5.5	-2.4	1.2	1.2	-1.2	-1.6	1.5	-1.7	-0.5	-1.9	-1.0	-1.5
Leg fat mass (right)	0.6	2.3	4.3	-2.0	1.3	1.3	-1.2	-1.7	1.4	-1.7	-0.7	-2.1	-1.1	-1.8
Arm predicted mass (right)	0.6	3.1	6.0	-1.9	2.0	1.8	-1.8	-1.9	1.1	-0.4	-1.3	-2.3	-1.4	-2.4
Pulse rate, automated reading	1.8	5.7	15.4	-3.9	2.6	2.2	-2.7	-1.0	1.6	2.2	-2.9	-1.4	-1.7	-2.4
Alcohol intake frequency.	0.3	0.7	6.0	-0.5	0.5	0.8	-0.7	0.1	2.4	-0.1	-0.1	-0.5	-0.4	-0.0
Comparative height size at age 10	0.5	2.7	4.8	1.8	-1.7	-1.9	1.5	1.1	1.7	1.3	1.1	2.2	1.9	1.8
Number of full sisters	1.1	1.3	7.0	1.7	-1.1	-1.0	1.1	-0.5	0.1	-2.6	0.1	-0.1	-0.2	0.7
Suffer from ‘nerves’	1.6	2.5	4.4	-1.2	1.7	1.7	-1.8	-1.4	0.2	-0.7	-1.9	-2.0	-1.6	-2.1
Overall health rating	1.8	3.8	9.6	-1.9	2.1	2.1	-2.3	-1.3	3.1	0.1	-1.7	-1.9	-1.7	-1.8
Chest pain or discomfort	0.6	0.9	1.7	-1.3	1.0	1.3	-1.0	-0.6	0.4	-0.1	-0.7	-1.1	-0.8	-1.1
Had major operations	0.4	0.4	1.0	0.5	-0.9	-1.0	0.8	0.3	-0.5	-0.3	0.5	0.8	0.5	0.7
Age at last live birth	1.0	1.5	3.2	1.7	-1.5	-1.0	1.6	0.8	-0.1	-1.2	1.0	0.9	0.5	1.8
Family relationship satisfaction	1.2	1.4	4.2	1.3	-1.5	-1.3	1.5	-0.6	-0.9	-2.0	0.5	0.6	0.2	1.2
Leg pain on walking	2.2	2.7	4.8	-2.2	1.8	1.7	-1.9	-2.1	1.6	-0.1	-0.5	-1.8	-1.6	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.9	-1.4	0.5	0.3	-0.5	-1.1	-0.4	0.3	-1.1	-0.3	-0.8	-0.4
Commuting to job workplace: Car/motor vehicle	1.4	1.7	4.0	-1.6	1.2	1.2	-1.0	-1.3	0.5	-1.7	-0.5	-2.0	-1.2	-1.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	4.6	0.2	-0.3	-0.4	0.3	1.3	0.0	2.2	0.2	1.3	1.0	0.3
Medication: Aspirin	0.5	0.6	2.5	0.6	-0.2	-0.2	0.2	0.8	1.6	1.0	0.7	0.8	1.0	0.4
Supplements: Vitamin C	1.6	1.8	3.6	-1.5	1.8	1.9	-1.7	-0.3	0.6	0.6	-1.2	-1.4	-1.3	-1.5
Knee pain experienced in last month	0.4	0.6	1.7	0.5	-0.9	-1.0	0.8	-0.1	-0.3	-0.9	1.3	0.2	0.4	0.9
Hypertension (Self-reported)	0.4	1.1	9.5	0.1	-0.0	-0.2	0.1	-0.2	3.1	-0.9	0.9	-0.3	0.7	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.7	-1.5	1.4	1.2	-1.6	-0.0	1.5	-0.8	-0.1	-1.6	-0.5	-1.5
Illnesses of father: Heart disease	1.5	2.1	3.1	-1.4	1.8	1.8	-1.7	-0.1	1.2	1.7	-1.8	-0.9	-1.4	-1.3
Illnesses of siblings: Diabetes	0.4	0.5	1.0	-0.3	0.8	0.7	-0.8	-0.0	0.4	-0.1	-1.0	-0.9	-0.9	-0.8
Smoking status: Previous	0.2	0.3	1.0	-0.1	0.7	0.5	-0.6	1.0	0.7	0.2	-0.1	-0.7	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	-0.1	0.4	0.2	-0.3	-0.6	0.8	-0.7	-0.3	-0.7	-0.4	-0.3
Whole body fat-free mass	0.3	1.7	3.3	-1.0	1.4	1.2	-1.2	-1.7	0.9	-0.6	-1.0	-1.8	-1.1	-1.8
Leg fat-free mass (right)	0.3	1.4	2.6	-1.2	1.1	0.9	-1.0	-1.5	1.1	-1.0	-0.8	-1.6	-1.2	-1.4
Arm fat percentage (left)	0.7	2.7	6.7	-2.6	1.3	1.5	-1.4	-1.6	1.3	-1.9	-0.6	-2.1	-1.3	-1.6
Average weekly red wine intake	1.5	2.2	4.5	1.7	-1.6	-1.3	1.7	2.1	0.8	-0.8	1.5	1.3	1.3	1.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.9	-0.6	0.0	-0.0	-0.2	-0.6	1.7	0.9	0.5	0.3	0.2	0.0
Mood swings	0.7	1.2	3.8	-0.2	1.4	1.3	-1.4	-0.8	1.9	1.0	-0.8	-0.8	-0.4	-1.0
Loneliness, isolation	1.1	1.5	2.0	1.4	-1.3	-1.0	1.3	1.2	1.4	-0.8	1.1	1.0	1.2	1.3
Long-standing illness, disability or infirmity	0.3	0.5	2.6	-0.1	0.2	0.5	-0.3	-0.5	1.6	-0.9	-0.9	-0.5	-0.4	-0.4
Ever had bowel cancer screening	2.9	3.4	4.9	1.6	-2.2	-2.1	2.2	1.9	-1.9	-0.1	1.5	2.1	1.4	2.2
Diabetes diagnosed by doctor	0.3	0.5	4.2	0.3	0.1	0.2	-0.0	0.4	2.0	0.9	0.1	0.2	0.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	3.3	0.3	-0.4	-0.2	0.3	0.3	1.8	-0.0	0.6	0.3	0.7	0.3
Friendships satisfaction	1.1	1.4	4.2	1.6	-1.5	-1.3	1.5	-0.1	-0.4	-2.1	0.6	0.6	0.2	1.2
Qualifications: nursing, teaching	1.0	1.5	6.2	1.2	-1.4	-1.5	1.6	0.5	-0.6	-2.5	0.2	0.4	0.3	0.9
Commuting to job workplace: Walk	3.1	3.4	5.5	2.4	-2.1	-2.3	2.0	1.6	-1.6	-0.1	1.6	2.0	1.6	1.7
Eye problems/disorders: Cataract	4.4	5.1	9.5	1.4	-2.3	-2.3	2.3	3.1	1.5	0.1	2.6	2.4	2.7	2.5
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	6.9	-1.2	1.5	2.0	-1.2	-2.0	0.0	-2.1	-1.9	-2.3	-2.6	-1.3
Medication for cholesterol	2.0	3.1	4.7	-2.0	2.0	1.6	-1.9	-1.7	-1.1	1.3	-2.2	-1.4	-1.9	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.4	-0.5	0.1	0.2	0.0	-0.2	1.2	-0.5	-0.2	-0.2	0.2	-0.0
Back pain experienced in last month	1.0	1.5	2.8	-0.8	1.2	1.5	-1.3	-1.1	-0.6	-1.0	-1.0	-1.6	-1.2	-1.7
Mineral and other dietary supplements	1.0	1.3	3.9	0.1	-0.7	-0.7	0.6	0.3	2.0	1.6	1.1	1.5	1.3	1.2
Breast cancer (self-reported)	0.2	0.3	1.8	0.0	0.1	-0.0	-0.2	-0.3	-0.6	0.4	-1.3	0.1	-0.6	-0.1
Asthma (self-reported)	0.1	0.2	1.1	-0.0	-0.2	0.1	0.1	1.1	-0.6	0.4	0.2	0.4	-0.4	0.7
Osteoporosis (self-reported)	1.7	2.0	3.1	1.5	-1.8	-1.7	1.6	1.2	0.5	-0.3	1.3	1.6	1.7	1.6
Osteoarthritis (self-reported)	1.8	2.4	4.4	-0.9	1.4	1.4	-1.5	-1.2	-1.4	-1.3	-1.7	-2.0	-2.1	-1.7
Medication: Aspirin	0.4	0.5	2.7	0.2	0.2	0.2	-0.2	0.7	1.6	1.2	0.3	0.4	0.6	0.0
Medication: Gliclazide	2.6	2.9	5.1	1.7	-1.8	-1.6	2.0	2.1	0.5	0.6	1.3	2.0	1.8	2.3
Illnesses of father: None of the above (group 1)	0.5	0.7	4.7	0.1	-0.5	-0.4	0.7	0.3	-1.1	-2.2	0.2	-0.5	-0.3	0.3
Smoking status: Current	0.6	0.9	8.2	-0.4	0.4	0.5	-0.5	0.4	2.9	-0.4	0.3	-0.6	0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.2	-0.7	1.4	1.7	-1.0	-1.6	-0.3	-0.9	-0.7	-1.8	-1.5	-1.2
Whole body water mass	0.3	1.8	3.4	-1.0	1.4	1.2	-1.3	-1.8	0.7	-0.7	-1.1	-1.8	-1.2	-1.9
Leg predicted mass (right)	0.3	1.4	2.6	-1.1	1.1	0.9	-1.0	-1.5	1.2	-0.9	-0.8	-1.6	-1.1	-1.4
Arm fat mass (left)	0.8	3.2	5.8	-2.4	1.6	1.6	-1.5	-2.1	1.4	-1.9	-0.8	-2.4	-1.4	-2.0
Number of self-reported non-cancer illnesses	0.7	1.3	7.5	-0.6	0.9	1.1	-0.9	0.0	2.7	-1.0	0.3	-1.2	-0.4	-0.8
Average weekly champagne plus white wine intake	0.2	0.3	1.2	-0.6	0.2	0.1	-0.3	0.6	1.1	1.0	0.2	0.1	0.0	-0.1
Miserableness	0.9	1.6	2.5	-0.7	1.5	1.4	-1.5	-1.3	0.2	-0.2	-1.4	-1.5	-1.2	-1.6
Guilty feelings	0.8	1.2	2.8	-0.5	0.6	0.6	-0.6	-1.2	1.4	-1.7	-1.6	-1.2	-1.0	-0.8
Wears glasses or contact lenses	0.5	0.6	1.4	0.4	-0.8	-0.7	0.8	0.9	-1.2	0.4	0.6	0.9	0.3	1.1
Ever taken oral contraceptive pill	1.6	1.8	4.7	1.2	-1.7	-2.2	1.7	1.2	-0.0	-0.8	0.9	1.2	1.1	1.5
Hearing aid user	0.1	0.1	0.5	-0.5	0.2	0.2	-0.4	0.1	0.1	0.7	-0.6	0.1	-0.1	-0.2
Mother’s age at death	2.0	2.5	5.1	-1.8	2.1	2.1	-2.2	-1.0	-0.2	2.2	-0.7	-1.0	-0.9	-1.6
Financial situation satisfaction	0.7	0.8	3.7	0.5	-0.4	-0.4	0.7	-1.9	-0.6	-1.8	0.1	-0.4	-0.7	0.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.8	-0.8	0.9	0.9	-0.9	-1.4	0.4	-0.3	-0.6	-1.0	-1.0	-0.8
Commuting to job workplace: Public transport	1.1	1.3	2.0	1.4	-1.4	-1.4	1.4	0.9	-0.3	0.1	1.1	1.4	1.0	1.4
Eye problems/disorders: Glaucoma	3.3	3.9	5.6	1.6	-2.3	-2.3	2.4	1.8	-0.7	0.2	2.2	2.2	2.4	2.2
Medication: Blood pressure	0.3	0.6	4.9	0.4	-0.0	0.2	0.0	-0.0	2.2	-0.5	0.8	-0.1	0.5	0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.7	0.5	-0.5	-0.3	0.5	0.3	1.3	-0.1	0.6	0.5	-0.1	0.4
Supplements: Fish oil (including cod liver oil)	2.2	2.9	8.0	-0.8	1.4	1.4	-1.2	-1.0	-2.8	-1.1	-2.2	-1.9	-1.9	-1.9
High cholesterol (Self-reported)	0.7	1.2	4.2	-0.8	1.1	0.9	-1.2	0.1	2.1	1.5	-1.1	-0.3	-0.1	-1.1
Medication: Bendroflumethiazide	0.2	0.3	1.4	0.4	0.0	0.3	-0.1	-0.2	1.2	0.1	0.9	0.1	0.5	0.2
Medication: Paracetamol	0.6	0.9	4.2	-0.5	0.1	0.4	-0.1	-0.6	1.8	-2.0	-0.1	-1.0	-0.7	-0.2
Medication: Lisinopril	0.3	0.4	1.8	0.6	-0.2	-0.2	0.3	0.2	0.7	-1.4	1.0	-0.4	-0.1	0.1
Medication: Atorvastatin	2.4	3.0	6.9	-2.6	1.7	1.5	-1.8	-1.2	2.1	1.1	-2.1	-1.1	-1.4	-1.8
Illnesses of father: High blood pressure	0.2	0.3	1.0	0.6	-0.3	-0.2	0.3	-1.0	0.6	-0.3	0.9	0.1	0.3	0.3
Alcohol drinker status: Never	2.2	2.6	4.7	1.7	-2.2	-1.8	2.1	0.8	-0.8	-1.7	1.6	1.4	0.5	2.1
Ever smoked	0.4	0.8	3.9	1.4	-0.1	-0.4	0.1	2.0	1.3	0.2	0.2	0.1	0.8	-0.2
Basal metabolic rate	0.3	1.8	3.3	-1.1	1.3	1.1	-1.2	-1.8	1.0	-0.9	-0.9	-1.8	-1.1	-1.8
Leg fat percentage (left)	0.4	1.4	3.6	-1.9	0.9	1.1	-0.9	-0.8	1.4	-1.3	-0.1	-1.6	-0.6	-1.3
Arm fat-free mass (left)	0.5	2.6	5.2	-1.3	1.8	1.5	-1.6	-2.0	0.6	-0.8	-1.2	-2.2	-1.3	-2.3
Number of operations (self-reported)	1.1	1.6	2.7	0.8	-1.6	-1.6	1.6	0.7	0.0	-1.6	1.3	0.8	1.1	1.4
Average weekly beer plus cider intake	0.7	1.0	2.2	-0.3	0.9	0.6	-0.9	-1.3	1.1	-1.4	-0.3	-1.5	-1.0	-0.9
Irritability	2.7	4.6	8.7	3.0	-2.3	-2.3	2.3	1.3	1.4	-0.2	2.5	2.2	2.3	2.4
Risk taking	0.5	0.7	4.0	0.2	0.0	0.1	-0.1	-0.6	-1.3	-2.0	0.2	-0.9	-0.3	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.2	1.1	-0.3	0.2	0.3	-0.3	0.1	1.1	0.2	0.5	0.0	0.1	0.0
Fractured/broken bones in last 5 years	0.6	0.7	2.0	-0.2	-0.7	-0.7	0.9	0.7	1.0	0.1	1.4	0.6	1.0	1.1
Age started oral contraceptive pill	0.7	0.9	2.5	0.5	-0.8	-0.5	0.5	1.2	-0.9	-0.2	1.6	0.7	1.4	1.2
Diastolic blood pressure, automated reading	0.7	2.1	4.0	0.2	-1.7	-2.0	1.9	1.0	1.3	0.3	1.0	1.9	1.5	1.8
Ever depressed for a whole week	1.0	1.2	2.8	-1.0	1.2	1.1	-1.1	-1.7	-0.5	0.3	-1.3	-1.1	-0.9	-1.2
Unable to work because of sickness or disability	0.9	1.1	2.1	-0.8	1.2	1.3	-1.2	-0.8	1.4	-0.1	-1.2	-1.2	-0.7	-1.1
Commuting to job workplace: Cycle	0.3	0.3	1.0	0.9	-0.1	-0.1	0.3	0.4	-0.3	1.0	0.5	0.6	1.0	0.2
Myopia	0.4	0.6	3.2	0.8	-0.3	-0.1	0.3	1.8	0.4	0.9	0.8	0.6	0.2	0.7
Vascular/heart problems diagnosed by doctor	0.5	1.3	11.8	0.5	-0.7	-0.4	0.7	0.1	-3.4	-0.1	-0.2	0.5	-0.4	0.5
Cholesterol lowering medication	0.4	0.6	1.6	0.8	-0.7	-0.3	0.7	1.2	1.3	-0.6	0.6	0.5	0.8	0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.1	-0.4	1.0	1.3	-1.2	-0.3	1.8	0.4	-0.9	-0.7	-0.3	-0.9
Pain experienced in last month	0.4	0.7	1.3	1.0	-1.0	-0.9	1.0	1.1	-0.3	-0.6	0.5	0.7	0.5	1.1
Supplements: Calcium	0.7	0.8	2.3	-0.5	0.5	0.8	-0.5	-1.0	1.2	-1.5	-0.4	-1.1	-0.9	-0.5
Basal cell carcinoma (self-reported)	1.1	1.3	3.2	1.8	-1.2	-0.8	1.4	0.8	-1.6	-0.4	0.7	1.0	0.6	1.1
Heart attack/myocardial infarction (self-reported)	1.3	1.6	3.3	-0.4	1.5	1.4	-1.4	-1.8	0.2	-0.3	-1.2	-1.6	-1.1	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.0	0.8	-1.1	-0.8	1.0	-0.0	0.8	-1.5	1.7	0.4	1.1	0.7
Heart disease (siblings)	0.4	0.4	1.8	0.5	-0.3	-0.1	0.2	0.5	1.4	0.6	0.5	0.6	1.1	0.5
Alcohol drinker status: Previous	0.3	0.4	1.4	0.7	-0.6	-0.3	0.3	-0.2	1.2	-1.1	-0.3	0.1	0.2	0.5
Pack years of smoking	0.6	0.9	4.2	-0.6	0.8	0.9	-0.8	-0.8	2.0	0.9	-0.9	-0.3	-0.4	-0.6
Impedance of whole body	1.1	5.6	10.6	1.6	-2.8	-2.5	2.6	2.8	0.8	0.4	2.3	3.0	2.3	3.2
Leg fat mass (left)	0.5	1.8	3.4	-1.9	1.0	1.1	-1.0	-1.4	1.4	-1.7	-0.4	-1.8	-0.9	-1.5
Arm predicted mass (left)	0.5	2.4	4.8	-1.2	1.7	1.5	-1.5	-2.1	0.8	-0.8	-1.1	-2.1	-1.2	-2.2