Best TWAS P=8.74e-12 · Best GWAS P=4.24e-18 conditioned to 1.48e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HSF2 | 0.14 | 0.14 | bslmm | 446 | 0.14 | 1.7e-16 | 6.4 | -6.3 | 3.9e-10 | 0.07 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Esophagus Mucosa | GJA1 | 0.25 | 0.05 | lasso | 10 | 0.11 | 8.5e-08 | -4.2 | 6.3 | 2.5e-10 | 0.43 | 0.28 | 0.67 | TRUE |
| 3 | METSIM | Adipose | GJA1 | 0.06 | 0.01 | bslmm | 348 | 0.03 | 4.0e-05 | 6.6 | 5.2 | 2.0e-07 | 0.49 | 0.11 | 0.74 | FALSE |
| 4 | YFS | Blood | SERINC1 | 0.06 | 0.05 | bslmm | 462 | 0.08 | 8.7e-25 | -3.7 | -6.8 | 8.7e-12 | 0.08 | 0.50 | 0.50 | TRUE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HSF2 | 0.03 | 0.03 | lasso | 2 | 0.02 | 2.5e-03 | 6.3 | -6.4 | 2.1e-10 | 0.04 | 0.02 | 0.88 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf170 | 0.05 | 0.01 | blup | 116 | 0.04 | 1.7e-03 | -2.8 | 5.1 | 2.9e-07 | 0.03 | 0.19 | 0.16 | TRUE |