Hub : Genes

GJA1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1320 0.0420 1.1e-05 0.073 NA 0.134 NA 0.131 4.0e-06 NA 2.9e-10 NA 5.0e-10
2 GTEx Esophagus Mucosa 0.2490 0.0570 7.0e-08 0.051 NA 0.076 NA 0.110 2.6e-04 NA 8.7e-06 NA 8.5e-08
3 GTEx Skin Sun Exposed Lower leg 0.1850 0.0550 5.1e-05 0.052 NA 0.037 NA 0.052 3.9e-05 NA 4.6e-04 NA 4.1e-05
4 METSIM Adipose 0.0603 0.0264 2.9e-04 0.010 0.028 0.024 0.028 0.011 9.5e-03 4.2e-05 1.2e-04 4e-05 7.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.0 0.0 0.0 -0.1 -0.2 -0.1 -0.2
Bipolar Disorder or Schizophrenia 0.0 0.0 0.1 0.1 -0.3 0.1 -0.3
Depressed Affect (Nagel 2018) 0.6 1.3 3.5 -0.9 -1.0 -0.2 -1.9
Depression (Nagel 2018) 0.7 1.1 3.5 -0.8 -0.3 -0.2 -1.9
Intelligence (Savage-Jansen 2018) 0.3 1.0 2.6 -0.6 0.2 0.9 -1.6
Neuroticism (Nagel 2018) 1.1 2.5 3.7 -1.0 -1.9 -1.3 -1.9
Schizophrenia (2018) 0.0 0.0 0.1 0.2 -0.2 0.2 -0.2
Schizophrenia vs Biploar Disorder 0.6 0.9 1.6 0.1 1.3 1.2 0.7
Worry (Nagel 2018) 0.2 0.5 1.0 -0.3 -1.0 -0.9 -0.1
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 -0.3 0.2 0.3 0.4
Alzheimer’s Disease (in father) 1.2 1.3 3.2 -0.7 -1.0 -0.8 -1.8
Alzheimer’s Disease (including proxy) 0.0 0.0 0.0 -0.2 -0.1 -0.1 -0.0
Crohns Disease (2017) 0.1 0.2 0.5 0.7 0.0 0.4 0.0
Irritable Bowel Disease (IBD) 0.4 0.9 1.8 1.1 0.8 1.3 -0.2
Ulcerative Colitis (UC) 0.6 1.2 3.1 0.8 1.0 1.8 -0.3
Major Depression (MDD) 0.2 0.3 0.6 -0.7 0.0 0.0 -0.7
Reaction Time 0.5 0.9 2.7 -0.9 0.4 -0.4 -1.6
Verbal and Numeric Reasoning (VNR) 0.6 1.5 2.3 -1.0 0.9 1.4 -1.5
Breast Cancer 1.5 3.7 4.5 1.4 2.0 2.1 2.1
Ovarian Cancer 0.6 0.7 2.5 -0.2 0.7 -0.1 1.6
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.0 0.0 0.1 -0.0 -0.2 -0.2 -0.1
Bipolar Disorder (2011) 2.0 1.9 2.8 -1.1 -1.1 -1.7 -1.6
Body Mass Index (BMI) (2010) 0.3 0.4 0.9 -0.3 -0.4 -0.6 -0.9
Coronary Artery Disease (CAD) 0.7 0.9 1.6 -0.5 0.7 1.0 1.3
Crohns Disease (2012) 0.2 0.3 0.8 0.2 -0.1 0.9 0.7
Mean Putamen Volume 0.9 1.0 3.5 -0.0 -0.0 0.6 -1.9
Fasting Glucose 0.9 1.1 2.4 -0.1 -1.3 -1.5 -0.5
HbA1C 1.7 1.9 5.4 0.4 -1.4 0.5 -2.3
HDL Cholesterol 1.8 2.9 6.8 -0.9 -2.6 -0.9 -1.8
LDL Cholesterol 0.7 1.1 3.0 -0.2 0.9 1.7 -0.6
Lupus 0.3 0.5 1.0 -0.3 -1.0 -0.9 -0.1
Neuroticism (2016) 1.1 1.6 3.6 -1.9 -0.2 0.0 -1.7
Primary Biliary Cirrhosis 1.6 2.3 3.4 0.8 -1.6 -1.8 -1.7
Rheumatoid Arthritis 0.9 1.2 2.3 -0.2 1.2 1.0 1.5
Schizophrenia (2014) 0.3 0.7 1.1 0.9 -0.8 -0.6 -1.1
Triglycerides 0.8 1.3 2.4 0.3 1.5 1.5 0.8
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.2 0.6 0.8 1.1 -0.1
Ulcerative Colitis 0.3 0.5 0.9 0.4 0.9 1.0 -0.2
Blood Eosinophil Count 0.2 1.9 3.4 -1.7 1.1 1.8 0.0
Blood Platelet Count 0.3 3.2 6.1 -0.8 -2.2 -1.1 -2.5
Blood Red Count 2.0 19.8 40.1 1.1 6.3 3.3 5.2
Blood White Count 0.7 5.3 10.2 -0.5 2.5 2.2 3.2
Heel T-Score 2.9 23.2 40.2 -4.6 -5.5 -1.1 -6.3
BMI 0.1 0.8 2.3 -0.4 0.8 -0.3 -1.5
Height 0.5 9.1 32.6 -0.4 -5.7 -1.9 -0.4
Waist Hip Ratio (WHR) 0.1 0.6 1.1 0.6 -0.8 -0.6 1.1
Systolic Blood Pressure 0.8 4.2 8.9 -3.0 -0.9 2.4 -1.3
Smoking Status 0.3 0.7 1.9 -0.0 -0.9 -0.1 -1.4
Allergy or Eczema 0.3 0.8 2.0 0.1 -1.0 -0.6 -1.4
Cardiovascular Disease 0.2 0.7 1.1 0.7 -0.8 -0.8 -1.1
Hypothyroidism (self reported) 0.4 0.8 3.2 1.8 -0.3 -0.3 -0.1
Respiratory disease 3.4 7.6 17.4 -0.5 -3.0 -2.0 -4.2
Type 2 Diabetes (T2D) (2018) 1.3 2.4 4.4 1.3 2.1 1.7 0.8
Lung FEV1/FVC ratio 4.2 21.1 39.6 6.0 2.9 -1.0 6.3
Lung FVC 0.9 4.5 9.2 3.0 0.6 -1.3 2.6
Neuroticism 0.8 1.9 3.6 -0.8 -1.6 -1.0 -1.9
Chronotype (morning person) 1.4 3.3 8.5 -2.9 0.9 1.7 -0.9
Hair Pigment 0.1 2.0 5.6 2.4 0.4 -0.3 1.5
Tanning 0.2 2.5 5.5 0.3 1.1 2.3 -1.9
Hand grip strength (left) 0.1 0.2 0.4 -0.6 -0.1 0.6 0.1
Number of treatments/medications taken 0.4 0.7 1.7 1.3 -0.4 -0.9 -0.3
Average weekly spirits intake 0.7 0.9 2.3 -0.2 1.1 1.5 0.2
Sensitivity / hurt feelings 0.5 0.8 2.6 1.6 -0.0 -0.8 0.3
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.4 -0.7 -0.3 0.3 -0.5
Hearing difficulty/problems: Yes 0.6 0.9 1.7 -1.3 -1.0 -0.6 -0.7
Relative age of first facial hair 0.7 1.5 3.3 1.8 -0.2 -0.3 1.6
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.2 1.1 0.2 -1.5 -0.1
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.1 -1.5 -0.2 0.5 -1.1
Ever had hysterectomy (womb removed) 0.4 0.5 0.8 0.6 0.8 0.9 0.2
Systolic blood pressure, automated reading 1.4 4.2 9.0 -2.5 0.1 3.0 -1.2
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.9 -0.6 1.4 1.2 0.2
Angina 0.1 0.1 0.3 -0.0 0.1 0.6 -0.5
Medication for hormone replacement therapy 0.6 0.6 1.3 -0.2 1.1 1.1 -0.2
Vitamin and mineral supplements 1.5 2.0 3.7 -1.7 0.8 1.9 -1.0
Supplements: Zinc 0.7 0.7 2.2 -0.0 0.8 0.3 1.5
Medication: Co-codamol 1.2 1.3 2.5 0.5 -1.6 -0.7 -1.4
Medication: Metformin 1.8 2.5 5.0 0.6 2.2 2.1 -0.5
Diabetes (father) 0.3 0.3 1.1 -0.2 1.1 0.1 0.5
Diabetes (mother) 0.2 0.2 0.6 0.2 -0.3 -0.8 -0.4
Severe depression (siblings) 0.4 0.5 1.1 1.1 -0.3 -0.0 -0.9
Pack years adult smoking proportion 0.2 0.2 0.6 -0.8 -0.5 0.2 -0.1
Impedance of leg (right) 0.1 0.7 1.6 0.9 -0.5 -0.3 1.3
Leg fat-free mass (left) 0.4 1.9 4.1 -1.1 -1.3 -0.6 -2.0
Trunk fat percentage 0.1 0.5 1.8 -0.5 -0.1 -0.0 -1.4
Hand grip strength (right) 0.1 0.3 0.6 -0.4 -0.7 0.5 -0.4
Townsend deprivation index at recruitment 0.2 0.3 0.9 -0.9 0.2 0.4 -0.1
Current tobacco smoking 0.2 0.3 0.6 0.0 -0.8 -0.3 -0.6
Average weekly fortified wine intake 1.1 1.3 2.4 1.1 1.6 1.2 0.1
Maternal smoking around birth 0.3 0.4 0.9 -0.6 0.0 -0.9 -0.7
Fed-up feelings 0.6 1.1 2.7 -1.6 -0.6 -0.1 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.8 6.2 -0.9 -1.6 -1.3 -2.5
Relative age voice broke 1.1 1.7 3.9 0.3 -1.6 -2.0 -0.7
Taking other prescription medications 0.5 0.8 1.6 1.2 -0.3 -0.4 -1.3
Age when periods started (menarche) 0.5 1.2 2.7 1.2 0.7 0.2 1.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.4 -0.6 0.4 1.2 0.5
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.5 7.8 -2.3 -2.0 0.8 -2.8
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 3.7 -1.9 0.1 1.0 -1.1
Qualifications: CSEs or equivalent 0.7 0.9 2.4 -0.8 0.4 -0.4 1.6
Serious illness, injury or assault to yourself 1.7 2.0 4.0 2.0 0.9 -1.0 1.5
High blood pressure 0.1 0.2 0.4 -0.3 -0.0 0.7 -0.5
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.4 -0.7 -0.8 -0.4 -1.2
Multivitamins +/- minerals 2.0 2.5 4.8 1.8 -0.9 -2.2 1.1
Stomach or abdominal pain in last month 1.7 2.1 4.0 -2.0 -1.4 -0.3 -1.6
Supplements: Glucosamine 0.4 0.5 1.2 -0.1 -1.1 -0.5 -0.8
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 -0.7 -0.3 0.2 -0.4
Medication: Atenolol 0.5 0.6 0.9 0.9 1.0 0.6 0.4
Medication: Levothyroxine sodium 0.1 0.2 0.5 0.7 -0.3 0.3 -0.5
Sitting height 0.4 2.7 6.6 -0.7 -2.6 -0.2 -2.0
Chronic bronchitis/emphysema (father) 0.5 0.5 1.7 0.7 -0.1 -0.2 1.3
High blood pressure (mother) 0.1 0.2 0.3 0.5 0.1 0.3 0.6
Body mass index (BMI) 0.3 1.3 2.2 -1.1 1.1 0.6 -1.5
Impedance of leg (left) 0.2 0.8 1.7 1.2 -0.2 0.0 1.3
Leg predicted mass (left) 0.4 1.9 4.3 -1.1 -1.3 -0.6 -2.1
Trunk fat mass 0.2 1.0 3.2 -0.8 -0.5 0.0 -1.8
Waist circumference 0.2 0.6 1.2 -1.1 0.1 0.2 -1.1
Number of incorrect matches in round 0.2 0.3 0.6 0.0 -0.6 -0.8 0.1
Past tobacco smoking 0.7 1.3 3.8 0.9 0.8 -0.3 2.0
Alcohol usually taken with meals 0.8 1.3 2.8 -0.3 -1.7 -1.2 -0.8
Nervous feelings 0.3 0.5 1.2 -0.3 -1.1 -0.8 -0.4
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 4.3 -1.5 -0.0 -0.3 -2.1
Hearing difficulty/problems with background noise 1.3 2.2 3.4 -1.8 -1.1 -1.6 -1.2
Hair/balding pattern: Pattern 2 0.3 0.4 0.6 -0.7 -0.6 -0.8 0.2
Had menopause 0.6 0.7 1.0 -1.0 -0.7 0.6 -1.0
Had other major operations 0.6 0.7 1.1 -0.8 -1.0 -1.0 -0.5
Forced vital capacity (FVC) 0.8 2.9 5.2 2.3 -1.1 -1.9 1.3
Heel bone mineral density (BMD) T-score, automated (right) 2.6 6.0 8.7 -2.6 -2.9 -0.3 -3.0
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.4 1.6 0.3 0.0 0.8
Qualifications: None of the above 0.5 1.1 3.8 -1.9 -0.6 0.5 0.4
Financial difficulties in last 2 years 0.3 0.4 0.9 -0.1 1.0 0.7 -0.3
Mouth/teeth dental problems 0.5 0.7 1.2 1.1 0.6 -0.8 0.8
Heart attack 0.9 1.1 2.2 -0.4 -0.6 1.5 -1.3
Allergy 2.1 4.9 8.0 0.9 2.6 2.0 2.8
Pain all over the body in last month 0.4 0.5 1.5 -0.3 -0.4 -0.4 -1.2
Diabetes (self-reported) 1.6 2.4 4.1 1.3 2.0 1.9 0.7
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.6 -0.1 -0.5 -0.8 0.4
Medication: Ramipril 0.7 0.9 2.5 0.9 -0.4 -0.2 -1.6
Medication: Simvastatin 0.8 1.1 3.5 1.9 0.3 0.6 0.8
Fluid intelligence score 0.6 1.2 2.3 -1.5 -0.2 0.3 -1.5
Illnesses of siblings 0.1 0.1 0.2 0.2 -0.4 -0.4 0.0
Neuroticism score 0.6 1.2 2.4 -0.9 -1.5 -0.8 -0.9
Weight 0.3 1.4 3.5 -1.2 -0.7 -0.1 -1.9
Impedance of arm (right) 0.4 2.0 4.3 0.4 -1.7 -2.1 0.6
Arm fat percentage (right) 0.2 0.8 2.1 -0.9 0.4 0.1 -1.5
Trunk fat-free mass 0.4 2.1 4.2 -1.3 -1.6 -0.0 -2.0
Hip circumference 0.5 2.1 4.7 -1.9 -0.4 0.1 -2.2
Time employed in main current job 0.8 1.0 1.5 -0.9 -0.1 1.2 -1.2
Alcohol intake versus 10 years previously 0.3 0.4 1.3 0.2 -0.6 -1.1 0.4
Father’s age at death 1.6 2.2 5.9 -2.4 -0.8 1.2 -0.9
Worrier / anxious feelings 1.2 2.3 3.2 1.8 -1.2 -1.6 1.4
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.2 0.4 0.2 -0.0 -1.1
Falls in the last year 2.3 3.2 5.8 -1.0 -2.4 -2.4 -0.0
Hair/balding pattern: Pattern 3 2.3 3.5 4.8 2.2 2.1 0.9 2.0
Number of live births 1.1 1.6 4.2 -2.0 -1.1 -1.0 0.0
Forced expiratory volume in 1-second (FEV1) 1.8 6.2 12.6 3.5 -0.2 -2.2 2.7
Pulse rate 28.1 47.4 71.9 8.2 6.0 -3.8 8.5
Happiness 1.0 1.2 1.6 -0.8 -1.2 -1.0 -1.3
Noisy workplace 2.7 3.3 7.7 0.0 1.9 1.3 2.8
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.8 0.3 -1.2 -1.4 0.2
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 3.5 0.3 -1.9 -1.3 -1.3
Mouth/teeth dental problems: Dentures 0.0 0.1 0.2 0.2 -0.4 0.3 -0.0
Asthma 3.3 6.5 15.5 -1.7 -2.6 -0.9 -3.9
Medication: Ibuprofen (e.g. Nurofen) 2.5 3.2 8.1 0.7 -0.4 -2.8 2.0
Medication: Cholesterol lowering 0.4 0.7 2.7 -0.1 0.1 1.6 -0.3
Depression (self-reported) 1.1 1.4 2.8 -1.0 -1.7 -0.3 -1.3
Medication: Lansoprazole 0.9 1.1 3.3 1.8 0.9 -0.5 0.0
Prospective memory result 1.8 2.3 4.8 2.2 -0.6 -1.2 1.5
Lung cancer (father) 1.2 1.3 2.7 1.4 -0.5 -0.7 1.6
Illnesses of mother 0.1 0.2 0.4 -0.2 0.6 -0.0 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 2.8 9.1 17.3 4.2 0.9 -1.6 4.0
Pulse wave Arterial Stiffness index 1.0 1.2 4.0 2.0 0.6 0.7 0.1
Impedance of arm (left) 0.7 3.1 6.8 1.2 -1.8 -2.6 1.0
Arm fat mass (right) 0.3 1.2 3.6 -1.2 -0.1 -0.1 -1.9
Trunk predicted mass 0.4 2.1 4.2 -1.4 -1.6 0.0 -2.1
Standing height 0.6 5.5 17.1 -0.2 -4.1 -2.0 -1.1
Length of working week for main job 0.9 1.0 3.2 -1.8 -0.8 -0.1 0.3
Exposure to tobacco smoke at home 0.1 0.1 0.2 0.1 0.5 -0.4 -0.3
Breastfed as a baby 2.1 2.5 4.3 -1.4 -2.1 -2.0 -0.4
Tense / ‘highly strung’ 1.0 1.7 3.1 -1.8 -1.5 -1.0 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.5 3.9 8.2 0.2 -2.9 -2.3 -1.4
Hair/balding pattern: Pattern 4 1.1 2.7 5.0 1.6 1.3 1.3 2.2
Birth weight of first child 0.4 0.8 1.9 -0.4 -0.6 -1.4 0.8
Peak expiratory flow (PEF) 2.1 4.9 9.9 3.1 -0.0 -2.4 2.0
Pulse wave reflection index 4.9 6.1 12.8 -1.7 -0.9 2.8 -3.6
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.3 -1.1 -0.6 -0.1 -1.1
Loud music exposure frequency 0.9 1.0 2.3 -0.4 0.8 0.9 1.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.7 0.5 0.6 0.2 0.8
Mouth/teeth dental problems: Bleeding gums 0.7 0.8 2.0 -0.5 0.7 1.4 -0.8
Blood clot in the leg (DVT) 3.0 3.9 8.0 0.9 -2.1 -2.8 -1.5
Medication: Paracetamol 2.2 3.7 10.1 0.6 -1.8 -3.2 1.0
Headache pain in last month 3.0 5.2 17.3 0.9 -1.4 -4.2 0.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.3 0.2 -0.7 -1.5 0.5
Glaucoma (self-reported) 0.9 1.1 2.1 -1.0 -0.9 0.7 -1.4
Gout (self-reported) 2.5 3.5 6.4 1.2 2.0 2.5 1.4
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.3 1.1 -0.6 -0.5 -0.4
Medication: Amlodipine 0.5 0.7 1.1 0.6 1.0 0.9 -0.8
Medication: Ventolin 100micrograms inhaler 1.5 1.9 4.4 -1.3 0.0 1.2 -2.1
Birth weight 0.8 1.8 5.2 -0.3 -0.3 -2.3 1.4
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.5 0.0 -0.3 -0.7 0.4
High blood pressure (siblings) 0.4 0.6 1.7 -0.5 0.5 1.3 -0.6
Forced vital capacity (FVC), Best measure 1.0 3.7 7.8 2.8 -0.2 -1.5 2.2
Body fat percentage 0.1 0.5 1.7 -0.5 0.3 0.2 -1.3
Leg fat percentage (right) 0.2 0.8 1.2 -0.9 0.8 0.8 -1.1
Arm fat-free mass (right) 0.2 1.2 2.7 -0.8 -1.1 0.2 -1.6
Exposure to tobacco smoke outside home 0.1 0.2 0.4 -0.3 0.2 0.5 -0.6
Comparative body size at age 10 0.2 0.6 1.2 -0.4 0.5 0.9 -1.1
Number of full brothers 0.1 0.1 0.2 -0.1 0.4 0.4 0.1
Worry too long after embarrassment 0.2 0.4 0.7 -0.0 -0.7 -0.9 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 4.0 5.3 9.7 -0.9 -3.1 -2.0 -2.5
Wheeze or whistling in the chest in last year 1.4 2.6 6.3 -1.7 -0.9 0.5 -2.5
Number of children fathered 0.2 0.2 0.6 -0.3 0.8 0.3 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 2.4 -0.6 -1.3 -1.6 0.1
Age at first live birth 2.0 3.6 6.1 2.5 -1.7 -2.3 -0.0
Pulse wave peak to peak time 1.1 1.3 3.8 -1.9 -0.9 -0.8 -0.3
Health satisfaction 0.5 0.7 1.0 -1.0 1.0 0.9 -0.1
Shortness of breath walking on level ground 1.4 1.6 2.4 -1.4 -1.4 -0.3 -1.5
Qualifications: College or University degree 0.7 2.2 4.1 1.8 0.1 -1.3 -2.0
Eye problems/disorders: None of the above 0.3 0.3 0.8 -0.1 0.9 0.1 0.7
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.0 -1.0 -0.8 0.2 -0.9
Emphysema/chronic bronchitis 2.2 2.5 5.3 -2.3 -0.7 -0.5 -2.0
Medication for pain relief, constipation, heartburn 1.4 2.3 5.4 -1.6 0.2 2.3 -1.2
Neck or shoulder pain in last month 0.8 1.1 2.4 -0.7 -1.2 -0.3 -1.6
Medication: Blood pressure 0.9 1.6 4.7 -0.4 0.9 2.2 -0.8
Angina (self-reported) 0.2 0.2 0.5 0.2 -0.0 0.5 -0.7
Migraine (self-reported) 3.1 3.9 11.4 0.3 -1.8 -3.4 1.0
Medication: Ibuprofen 2.7 3.3 10.0 0.1 -1.2 -3.2 1.3
Medication: Allopurinol 2.0 2.7 4.6 1.0 1.4 2.1 1.7
Medication: Omeprazole 0.6 0.7 1.9 0.5 -0.8 -1.4 -0.3
Medication: Seretide 50 evohaler 5.9 6.8 15.9 -4.0 -2.0 -0.4 -2.7
Mean time to correctly identify matches 1.0 1.8 5.3 -1.4 -0.2 -0.2 -2.3
Heart disease (mother) 0.5 0.6 1.1 0.6 -1.1 -0.9 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.6 0.2 0.8 1.3 -0.3
Whole body fat mass 0.3 1.1 3.3 -1.0 -0.2 0.2 -1.8
Leg fat mass (right) 0.2 0.8 2.3 -0.8 0.1 0.4 -1.5
Arm predicted mass (right) 0.2 1.0 2.8 -0.7 -0.8 0.5 -1.7
Pulse rate, automated reading 41.1 132.7 204.5 14.3 7.5 -8.5 14.1
Alcohol intake frequency. 0.1 0.2 0.5 0.1 0.4 0.6 0.7
Comparative height size at age 10 0.2 0.8 2.0 0.3 -1.4 -1.0 -0.6
Number of full sisters 0.9 1.1 3.0 -1.7 0.5 0.8 -0.6
Suffer from ‘nerves’ 0.6 0.9 1.5 -0.8 -0.8 -1.2 -1.0
Overall health rating 0.6 1.4 3.5 -0.5 -0.9 -1.0 -1.9
Chest pain or discomfort 2.8 4.1 9.7 -1.8 -1.7 -0.8 -3.1
Had major operations 0.2 0.3 0.6 -0.5 -0.8 -0.0 -0.4
Age at last live birth 1.7 2.5 6.0 1.3 -1.4 -2.4 -0.0
Family relationship satisfaction 1.1 1.3 3.5 0.0 -1.1 -0.8 -1.9
Leg pain on walking 1.9 2.4 4.6 -1.8 1.3 2.1 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.7 -0.8 -0.4 0.7 0.2
Commuting to job workplace: Car/motor vehicle 0.5 0.6 0.9 -1.0 -0.9 -0.4 0.7
Illness, injury, bereavement, stress in last 2 years 1.9 2.4 6.9 -2.6 -0.0 1.6 -0.1
Medication: Aspirin 0.6 0.8 1.7 1.3 1.0 0.7 0.4
Supplements: Vitamin C 0.2 0.3 0.6 0.4 -0.1 -0.6 0.7
Knee pain experienced in last month 0.1 0.1 0.3 -0.5 0.0 0.1 -0.3
Hypertension (Self-reported) 0.1 0.2 0.5 -0.2 0.1 0.5 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 2.0 -0.2 1.4 1.2 0.4
Illnesses of father: Heart disease 0.3 0.5 1.8 -0.2 0.3 1.3 -0.2
Illnesses of siblings: Diabetes 0.2 0.2 0.9 0.0 -0.9 -0.2 -0.2
Smoking status: Previous 0.5 0.8 2.4 -0.4 -0.5 0.5 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.5 0.2 -0.3 1.2 0.2
Whole body fat-free mass 0.3 2.0 4.2 -1.2 -1.4 -0.2 -2.1
Leg fat-free mass (right) 0.3 1.6 4.0 -1.0 -1.2 -0.5 -2.0
Arm fat percentage (left) 0.2 0.6 1.7 -0.7 0.4 -0.2 -1.3
Average weekly red wine intake 0.4 0.6 1.3 1.1 0.8 -0.5 0.1
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.3 -0.9 0.2 1.5 -1.5
Mood swings 0.2 0.4 1.1 0.3 -1.0 -0.8 -0.0
Loneliness, isolation 0.8 1.1 3.3 -0.7 -0.1 0.8 -1.8
Long-standing illness, disability or infirmity 0.8 1.2 2.0 0.2 1.4 1.2 -1.2
Ever had bowel cancer screening 1.6 1.8 3.3 0.1 -1.3 -1.8 1.5
Diabetes diagnosed by doctor 2.3 3.8 7.5 1.4 2.7 2.3 0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.0 -0.1 -1.0 -0.6 -0.8
Friendships satisfaction 1.6 2.0 5.1 -1.5 -0.7 0.5 -2.3
Qualifications: nursing, teaching 0.5 0.8 1.4 0.7 -1.1 -1.2 -0.5
Commuting to job workplace: Walk 0.9 1.0 1.6 -0.3 0.9 1.2 -1.3
Eye problems/disorders: Cataract 0.8 0.9 1.8 -0.5 -0.1 1.3 -1.3
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 2.6 0.6 -0.3 -0.8 1.6
Medication for cholesterol 0.6 0.9 1.5 -1.2 -1.2 -0.6 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.8 0.5 0.9 -0.3 0.6
Back pain experienced in last month 0.2 0.2 0.7 0.1 0.1 -0.4 -0.8
Mineral and other dietary supplements 0.5 0.6 2.0 -0.1 0.6 0.2 -1.4
Breast cancer (self-reported) 0.6 0.7 1.0 -0.5 -0.9 -0.8 -1.0
Asthma (self-reported) 3.7 7.4 17.7 -1.9 -2.7 -1.0 -4.2
Osteoporosis (self-reported) 1.3 1.6 2.6 1.5 0.6 -1.6 1.1
Osteoarthritis (self-reported) 0.5 0.6 1.7 -1.3 -0.1 0.6 -0.6
Medication: Aspirin 0.9 1.2 1.7 1.3 1.3 1.0 0.7
Medication: Gliclazide 3.4 3.8 6.8 1.0 2.6 1.4 2.3
Illnesses of father: None of the above (group 1) 0.2 0.3 0.4 0.6 0.5 0.3 0.6
Smoking status: Current 0.2 0.4 0.7 0.2 -0.9 -0.4 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.6 9.7 19.4 3.9 1.5 -1.2 4.4
Whole body water mass 0.3 1.9 4.2 -1.2 -1.4 -0.2 -2.0
Leg predicted mass (right) 0.3 1.8 4.1 -1.0 -1.2 -0.6 -2.0
Arm fat mass (left) 0.3 1.1 3.0 -1.1 -0.1 -0.2 -1.7
Number of self-reported non-cancer illnesses 2.0 3.5 9.8 0.2 -1.8 -0.8 -3.1
Average weekly champagne plus white wine intake 1.4 2.0 3.6 0.7 -1.2 -1.9 -1.5
Miserableness 0.4 0.7 1.3 -0.5 -0.7 -0.8 -1.1
Guilty feelings 2.4 3.6 7.7 0.2 -2.8 -1.9 -1.8
Wears glasses or contact lenses 0.4 0.5 1.3 -0.0 -0.6 -1.1 0.3
Ever taken oral contraceptive pill 0.1 0.1 0.4 -0.6 -0.2 0.2 0.2
Hearing aid user 1.4 1.6 3.1 -0.4 1.0 1.7 1.5
Mother’s age at death 0.4 0.5 1.7 -0.2 0.6 -0.0 1.3
Financial situation satisfaction 0.3 0.4 1.1 -0.1 0.6 1.1 -0.2
Tinnitus: Yes, now most or all of the time 0.2 0.3 1.0 -1.0 0.2 0.2 -0.3
Commuting to job workplace: Public transport 0.7 0.8 1.4 0.7 1.1 -0.3 -1.2
Eye problems/disorders: Glaucoma 0.7 0.9 2.0 -0.8 -0.6 0.7 -1.4
Medication: Blood pressure 0.1 0.2 0.4 0.1 -0.0 -0.7 0.4
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 -0.6 0.6 0.2 -0.4
Supplements: Fish oil (including cod liver oil) 0.8 1.1 2.1 0.3 -1.1 -1.4 0.9
High cholesterol (Self-reported) 0.5 0.9 1.4 0.9 -1.2 -0.7 -0.9
Medication: Bendroflumethiazide 0.2 0.3 0.6 -0.4 0.8 0.5 -0.5
Medication: Paracetamol 1.8 2.7 7.7 0.7 -1.4 -2.8 0.9
Medication: Lisinopril 0.3 0.4 0.8 0.7 -0.0 -0.6 -0.9
Medication: Atorvastatin 0.4 0.5 1.3 0.9 -0.1 0.2 -1.1
Illnesses of father: High blood pressure 2.2 2.7 3.5 -1.3 -1.6 -1.7 -1.9
Alcohol drinker status: Never 0.1 0.2 0.4 -0.5 0.0 0.6 0.3
Ever smoked 1.2 2.1 6.0 -0.8 -1.3 -0.4 -2.5
Basal metabolic rate 0.3 1.7 4.0 -1.2 -1.1 -0.1 -2.0
Leg fat percentage (left) 0.3 1.1 1.5 -0.8 1.0 1.2 -1.2
Arm fat-free mass (left) 0.3 1.7 3.8 -1.3 -1.0 0.5 -2.0
Number of operations (self-reported) 0.1 0.1 0.4 -0.1 -0.6 -0.2 0.4
Average weekly beer plus cider intake 0.7 1.0 1.4 0.5 1.1 1.2 1.1
Irritability 2.4 4.1 7.1 -2.7 -1.9 -0.9 -2.2
Risk taking 0.2 0.3 0.9 0.3 1.0 0.3 0.2
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.9 -0.9 0.2 0.6 -0.9
Fractured/broken bones in last 5 years 0.1 0.2 0.2 0.4 0.4 -0.5 0.3
Age started oral contraceptive pill 0.5 0.6 2.0 1.4 0.5 0.1 0.4
Diastolic blood pressure, automated reading 0.9 2.8 3.9 1.5 2.0 -1.6 1.6
Ever depressed for a whole week 0.0 0.1 0.1 -0.2 -0.4 -0.1 -0.1
Unable to work because of sickness or disability 1.0 1.3 2.4 1.0 -0.9 -1.6 -0.8
Commuting to job workplace: Cycle 1.7 2.0 3.0 1.7 1.4 0.9 1.6
Myopia 0.2 0.3 0.8 0.9 0.3 0.0 0.7
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.5 0.4 0.4 -0.5 0.7
Cholesterol lowering medication 2.2 3.3 10.9 3.3 0.6 -0.0 1.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 1.0 0.2 -0.2 -0.4 -1.0
Pain experienced in last month 0.8 1.3 2.4 0.5 1.0 1.6 1.3
Supplements: Calcium 1.5 1.7 2.8 1.6 0.6 -0.9 1.7
Basal cell carcinoma (self-reported) 0.6 0.7 2.4 -0.5 -0.3 -0.1 -1.5
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.1 -0.2 -0.4 1.5 -1.2
Deep venous thrombosis (DVT) (self-reported) 2.7 3.5 7.2 0.8 -1.9 -2.7 -1.5
Heart disease (siblings) 0.5 0.6 1.6 -0.8 -0.4 -1.2 0.4
Alcohol drinker status: Previous 0.3 0.3 0.5 0.7 0.7 0.1 0.5
Pack years of smoking 0.2 0.3 0.7 -0.6 -0.1 0.9 0.2
Impedance of whole body 0.3 1.3 1.8 1.2 -0.9 -1.1 1.4
Leg fat mass (left) 0.2 0.9 2.5 -0.8 0.2 0.7 -1.6
Arm predicted mass (left) 0.3 1.5 3.6 -1.2 -0.8 0.5 -1.9