TWAS hub - SERINC1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0880	0.043	0.0093	-0.004	NA	0.009	NA	-0.004	9.4e-01	NA	6.9e-02	NA	1.0e+00
2	YFS	Blood	0.0573	0.013	0.0000	0.046	0.079	0.079	0.08	0.079	8.6e-15	2e-24	1.5e-24	8.7e-25	1.5e-24

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Noisy workplace	6.7	8.2	14.9	1.3	-3.9
Crohns Disease (2017)	5.3	11.6	13.2	-3.2	3.6
Medication: Simvastatin	5.3	7.8	8.9	-2.6	3.0
Medication: Co-codamol	4.5	5.3	6.7	-2.0	2.6
Allergy or Eczema	4.4	11.7	15.4	3.9	-2.8
Happiness	4.4	5.3	7.8	-2.8	1.7
Irritable Bowel Disease (IBD)	4.3	10.3	10.8	-3.1	3.3
Risk taking	4.3	6.4	10.4	1.5	-3.2
Medication: Ibuprofen	4.1	4.9	8.0	1.3	-2.8
Hearing difficulty/problems: Yes	3.7	5.6	9.9	1.2	-3.1
Hair/balding pattern: Pattern 3	3.5	5.2	9.9	-3.1	0.8
Supplements: Calcium	3.4	3.8	7.2	-0.5	2.7
Hayfever, allergic rhinitis or eczema	3.3	7.2	8.1	2.9	-2.5
Diabetes (father)	3.2	4.0	5.0	-2.2	1.7
Diabetes (mother)	3.1	4.0	7.7	-0.5	2.8
Worrier / anxious feelings	3.1	5.8	8.0	-1.9	2.8
Blood Red Count	3.0	28.7	46.6	3.3	-6.8
Medication: Cholesterol lowering	3.0	4.6	5.9	-1.8	2.4
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	8.0	1.4	-2.8
Medication: Atenolol	2.6	3.2	4.2	-1.5	2.0
Nervous feelings	2.6	4.9	5.9	-2.0	2.4
Length of working week for main job	2.6	2.9	5.6	0.3	-2.4
Heart disease (mother)	2.6	3.1	4.5	-2.1	1.3
Number of treatments/medications taken	2.5	4.5	8.7	-0.5	3.0
Pulse rate, automated reading	2.5	8.2	11.7	2.2	-3.4
High cholesterol (Self-reported)	2.5	4.5	6.1	-2.5	1.7
Pulse rate	2.4	4.0	7.2	0.9	-2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	4.5	-2.1	1.7
Medication: Paracetamol	2.4	3.9	6.7	1.1	2.6
Hand grip strength (right)	2.3	6.3	7.8	2.2	-2.8
Tense / ‘highly strung’	2.3	3.9	5.6	-2.4	1.5
Exposure to tobacco smoke outside home	2.3	3.0	3.8	2.0	-1.5
Sensitivity / hurt feelings	2.1	3.5	6.2	-0.9	2.5
Medication: Lisinopril	2.1	2.7	2.8	-1.6	1.7
Ulcerative Colitis (UC)	2.0	3.8	5.3	-2.3	1.5
Crohns Disease (2012)	2.0	3.2	5.3	-1.1	2.3
Cardiovascular Disease	2.0	6.5	12.8	-0.5	3.6
Hearing difficulty/problems with background noise	2.0	3.1	4.4	1.4	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	4.0	0.8	2.0
Shortness of breath walking on level ground	2.0	2.4	3.2	-1.8	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.2	4.2	2.1	-0.2
Financial situation satisfaction	2.0	2.5	3.5	-1.2	1.9
Neuroticism (2016)	1.9	2.7	4.6	-0.9	2.1
Hair/balding pattern: Pattern 2	1.9	2.4	4.5	2.1	-0.5
Number of live births	1.9	2.7	5.0	2.2	0.6
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	3.8	1.0	-1.9
Suffer from ‘nerves’	1.9	3.0	3.2	-1.8	1.7
Schizophrenia vs Biploar Disorder	1.8	2.4	2.6	1.6	-1.5
Worry (Nagel 2018)	1.8	3.8	5.3	-2.3	1.5
Bipolar Disorder (2011)	1.8	1.7	2.9	-1.7	0.8
Rheumatoid Arthritis	1.7	2.3	3.0	-1.7	1.3
Lung FVC	1.7	8.5	13.9	-1.8	3.7
Neuroticism score	1.7	3.5	3.7	-1.9	1.8
Blood clot in the leg (DVT)	1.7	2.1	2.8	-1.2	1.7
Basal cell carcinoma (self-reported)	1.7	2.0	2.7	-1.6	1.1
Hypertension (Self-reported)	1.6	4.3	8.6	-0.3	2.9
Pain type(s) experienced in last month: Hip pain	1.6	2.0	3.4	1.8	-0.8
Hand grip strength (left)	1.5	3.9	5.1	1.6	-2.3
High blood pressure	1.5	4.1	7.4	-0.9	2.7
Number of incorrect matches in round	1.5	2.5	3.1	-1.3	1.8
Had menopause	1.5	1.9	3.4	0.6	-1.8
Lung cancer (father)	1.5	1.7	3.0	0.7	-1.7
Chronic bronchitis/emphysema (mother)	1.5	1.8	3.5	-0.1	-1.9
Supplements: Vitamin C	1.5	1.8	3.5	-1.9	0.3
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.3	-0.4	1.8
Hearing aid user	1.5	1.7	2.2	1.5	-1.1
Vascular/heart problems diagnosed by doctor	1.5	4.0	6.9	1.0	-2.6
Cholesterol lowering medication	1.5	2.2	2.2	-1.5	1.5
Neuroticism (Nagel 2018)	1.4	3.2	3.9	-2.0	1.6
Neuroticism	1.4	3.5	3.6	-1.8	1.9
Medication for hormone replacement therapy	1.4	1.5	2.9	-0.4	1.7
Fed-up feelings	1.4	2.5	4.4	-0.8	2.1
Exposure to tobacco smoke at home	1.4	1.6	3.1	1.8	-0.3
Medication for cholesterol	1.4	2.1	3.5	0.8	-1.9
Medication: Bendroflumethiazide	1.4	2.1	2.6	-1.6	1.3
Medication: Paracetamol	1.4	2.2	3.5	1.0	1.9
Alcohol drinker status: Previous	1.4	1.6	2.9	-1.7	0.6
Ever used hormone-replacement therapy (HRT)	1.3	1.7	2.1	1.4	-1.1
Breastfed as a baby	1.3	1.6	3.3	-0.2	-1.8
Worry too long after embarrassment	1.3	2.2	3.8	-1.9	0.7
Mother’s age at death	1.3	1.6	3.2	1.8	0.2
Ever had hysterectomy (womb removed)	1.2	1.4	2.4	1.6	-0.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.7	-1.3	0.9
Number of full brothers	1.2	1.5	2.2	-0.9	-1.5
Health satisfaction	1.2	1.5	2.7	-1.6	0.6
Medication: Blood pressure	1.2	2.1	4.2	-0.3	2.1
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	1.6	-1.2	1.3
High blood pressure (mother)	1.1	1.6	2.0	1.1	1.4
Alcohol usually taken with meals	1.1	1.8	2.8	1.7	-0.9
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.6	-1.6	-0.2
Allergy	1.1	2.5	3.6	-1.9	1.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	1.6	-1.3	-1.0
Medication for pain relief, constipation, heartburn	1.1	1.9	2.6	-1.1	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.4	1.2	-1.1
Knee pain experienced in last month	1.1	1.8	2.9	1.7	-0.8
Friendships satisfaction	1.1	1.3	1.4	-1.1	-1.2
Guilty feelings	1.1	1.7	1.9	-1.2	1.4
Age started oral contraceptive pill	1.1	1.4	2.2	-1.5	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	1.7	-1.3	1.0
Age at First Birth	1.0	1.4	1.9	-1.4	-0.9
Supplements: Glucosamine	1.0	1.3	2.3	1.5	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.0	-0.5	1.7
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.2	0.2	-1.5
Loud music exposure frequency	1.0	1.1	2.1	-1.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.6	-1.6	-0.0
Migraine (self-reported)	1.0	1.2	1.8	0.7	-1.3
Leg pain on walking	1.0	1.2	2.3	0.3	-1.5
Osteoporosis (self-reported)	1.0	1.2	2.5	1.6	0.0
Alzheimer’s Disease (in mother)	0.9	1.1	1.6	0.7	-1.3
Breast Cancer	0.9	2.2	4.5	-2.1	0.1
Severe depression (siblings)	0.9	1.1	1.1	1.1	-1.0
Stomach or abdominal pain in last month	0.9	1.2	1.2	-1.1	1.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.4	1.0	-1.2
Wheeze or whistling in the chest in last year	0.9	1.6	3.1	-0.0	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.0	-0.5	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	2.4	-1.1	1.5
Medication: Blood pressure	0.9	1.6	2.0	-1.1	1.4
Unable to work because of sickness or disability	0.9	1.2	2.1	-0.6	1.4
Relative age voice broke	0.8	1.2	2.1	-0.5	1.5
Pain all over the body in last month	0.8	0.9	0.9	0.9	-1.0
Impedance of arm (right)	0.8	3.8	6.5	-2.5	1.1
Family relationship satisfaction	0.8	1.0	1.3	-1.1	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.9	-0.3	1.4
Illnesses of father: None of the above (group 1)	0.8	1.0	1.1	1.0	-1.0
Number of operations (self-reported)	0.8	1.2	2.4	-1.5	-0.0
Average weekly beer plus cider intake	0.8	1.1	1.6	-1.3	0.9
Commuting to job workplace: Cycle	0.8	1.0	1.8	-1.3	0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.6	1.3	0.1
Smoking Status	0.7	1.7	1.8	1.3	-1.3
Vitamin and mineral supplements	0.7	1.0	1.9	0.3	-1.4
Pack years adult smoking proportion	0.7	1.0	1.4	-0.8	1.2
Had other major operations	0.7	0.8	1.6	0.0	-1.3
Forced vital capacity (FVC), Best measure	0.7	2.5	4.7	-0.6	2.2
Illnesses of father: Heart disease	0.7	1.0	1.3	-1.1	0.9
Mood swings	0.7	1.3	1.8	-0.9	1.3
Pain experienced in last month	0.7	1.1	1.3	-1.1	1.0
Schizophrenia (2018)	0.6	1.2	1.4	1.0	-1.2
Major Depression (MDD)	0.6	0.8	0.9	-0.9	0.8
Reaction Time	0.6	1.2	1.6	-1.2	-0.9
Triglycerides	0.6	0.9	1.5	-0.6	1.2
Supplements: Zinc	0.6	0.7	1.0	-1.0	0.6
Age when periods started (menarche)	0.6	1.4	2.6	0.5	-1.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.2	0.3	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.3	-1.5	0.5
Chronic bronchitis/emphysema (father)	0.6	0.8	1.3	-1.1	-0.4
Forced vital capacity (FVC)	0.6	2.3	4.5	0.2	2.1
Medication: Ramipril	0.6	0.8	1.6	1.3	0.0
Time employed in main current job	0.6	0.6	1.0	1.0	0.5
Falls in the last year	0.6	0.8	1.7	-1.3	-0.1
Pulse wave reflection index	0.6	0.8	1.5	-1.2	-0.1
Eye problems/disorders: None of the above	0.6	0.7	1.0	-1.0	0.6
Emphysema/chronic bronchitis	0.6	0.6	1.2	-0.2	1.1
Number of full sisters	0.6	0.7	0.7	-0.8	0.9
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.5	-0.1	-1.2
Eye problems/disorders: Glaucoma	0.6	0.7	1.5	-0.1	1.2
Diastolic blood pressure, automated reading	0.6	1.9	2.3	1.5	-1.3
Alzheimer’s Disease (including proxy)	0.5	0.7	1.0	0.6	-1.0
Ulcerative Colitis	0.5	0.7	1.0	-1.0	0.7
Average weekly fortified wine intake	0.5	0.6	1.1	1.0	-0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.8	0.5	0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.0	0.5	-1.0
Father’s age at death	0.5	0.6	1.1	1.1	0.4
Mouth/teeth dental problems: Dentures	0.5	0.8	1.3	-1.1	0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	0.2	1.1
Age at first live birth	0.5	0.8	0.9	-0.9	1.0
Medication: Omeprazole	0.5	0.6	1.1	-0.3	1.1
Age at last live birth	0.5	0.7	1.3	0.1	1.1
Long-standing illness, disability or infirmity	0.5	0.7	1.5	0.2	1.2
Breast cancer (self-reported)	0.5	0.6	1.0	0.3	1.0
Osteoarthritis (self-reported)	0.5	0.6	1.2	-1.1	-0.1
Ever taken oral contraceptive pill	0.5	0.6	1.1	-1.1	0.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	0.1	-1.1
Medication: Atorvastatin	0.5	0.6	0.7	-0.7	0.8
Myopia	0.5	0.8	1.4	0.4	-1.2
Pack years of smoking	0.5	0.7	0.9	-0.9	0.8
Impedance of whole body	0.5	2.3	3.8	-2.0	0.9
Schizophrenia (2014)	0.4	0.9	1.0	1.0	-0.9
BMI	0.4	2.2	4.4	2.1	0.4
Waist Hip Ratio (WHR)	0.4	1.8	2.6	1.0	-1.6
Average weekly spirits intake	0.4	0.5	0.9	-0.2	-1.0
Angina	0.4	0.5	0.8	0.4	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.6	-0.6	0.8
Multivitamins +/- minerals	0.4	0.5	0.9	-0.4	1.0
Depression (self-reported)	0.4	0.5	0.7	-0.8	0.5
Impedance of arm (left)	0.4	1.9	3.5	-1.9	0.6
Peak expiratory flow (PEF)	0.4	1.0	1.6	0.6	1.3
Arm fat-free mass (right)	0.4	1.9	3.6	1.9	-0.4
Mean time to correctly identify matches	0.4	0.8	1.4	-1.2	-0.5
Arm predicted mass (right)	0.4	2.3	4.4	2.1	-0.3
Number of self-reported non-cancer illnesses	0.4	0.6	1.2	-0.2	1.1
Average weekly champagne plus white wine intake	0.4	0.6	0.6	0.8	-0.7
Alcohol drinker status: Never	0.4	0.5	0.6	-0.7	0.8
Ever depressed for a whole week	0.4	0.5	0.9	-1.0	0.3
Bipolar Disorder or Schizophrenia	0.3	0.7	0.9	0.9	-0.8
Depressed Affect (Nagel 2018)	0.3	0.7	0.7	-0.8	0.9
Ovarian Cancer	0.3	0.3	0.7	-0.8	0.0
Coronary Artery Disease (CAD)	0.3	0.3	0.6	-0.8	-0.3
Fasting Glucose	0.3	0.4	0.6	0.4	0.8
Heel T-Score	0.3	2.0	2.0	1.4	-1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.9	1.0	0.5
Systolic blood pressure, automated reading	0.3	0.9	1.5	1.2	0.5
Impedance of leg (right)	0.3	1.2	1.4	-1.2	1.0
Townsend deprivation index at recruitment	0.3	0.4	0.8	-0.9	0.2
Current tobacco smoking	0.3	0.6	0.7	0.9	-0.6
Taking other prescription medications	0.3	0.4	0.9	-0.0	0.9
Financial difficulties in last 2 years	0.3	0.4	0.9	0.9	0.1
Trunk fat-free mass	0.3	1.5	2.9	1.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.5	0.6	1.2
Illnesses of mother	0.3	0.4	0.5	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.0	-0.2	1.4
Trunk predicted mass	0.3	1.5	3.0	1.7	0.2
Hair/balding pattern: Pattern 4	0.3	0.7	1.4	1.2	-0.1
Birth weight of first child	0.3	0.6	1.0	-0.4	-1.0
Headache pain in last month	0.3	0.5	0.8	0.9	-0.5
Glaucoma (self-reported)	0.3	0.3	0.7	-0.0	0.8
Medication: Amlodipine	0.3	0.4	0.6	-0.5	0.8
Angina (self-reported)	0.3	0.4	0.6	0.4	-0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.5	-0.7	-0.6
Smoking status: Previous	0.3	0.4	0.4	0.6	-0.7
Loneliness, isolation	0.3	0.4	0.8	-0.2	0.9
Ever smoked	0.3	0.6	1.1	1.1	-0.3
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	0.8	0.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	0.9	-0.4
Alzheimer’s Disease (in father)	0.2	0.3	0.4	0.6	-0.3
HDL Cholesterol	0.2	0.3	0.5	-0.2	0.7
LDL Cholesterol	0.2	0.3	0.5	-0.1	0.7
Lupus	0.2	0.3	0.5	-0.0	-0.7
Primary Biliary Cirrhosis	0.2	0.3	0.4	0.7	-0.4
Blood White Count	0.2	1.6	2.9	-1.7	0.5
Systolic Blood Pressure	0.2	0.8	1.4	0.4	1.2
Lung FEV1/FVC ratio	0.2	0.8	0.9	0.9	-0.9
Chronotype (morning person)	0.2	0.5	0.9	-0.0	-1.0
Medication: Levothyroxine sodium	0.2	0.4	0.4	0.7	0.6
Body mass index (BMI)	0.2	0.6	1.1	1.0	-0.5
Impedance of leg (left)	0.2	1.1	1.2	-1.1	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.7	-0.8	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	-1.0	-0.1
Heart attack	0.2	0.2	0.3	0.3	-0.6
Illnesses of siblings	0.2	0.3	0.6	-0.8	-0.2
Alcohol intake versus 10 years previously	0.2	0.2	0.5	-0.2	-0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.6	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.0	-0.7
High blood pressure (siblings)	0.2	0.3	0.4	0.6	0.6
Qualifications: College or University degree	0.2	0.7	1.0	-0.7	-1.0
Neck or shoulder pain in last month	0.2	0.3	0.4	0.5	-0.6
Comparative height size at age 10	0.2	1.0	1.9	-0.3	1.4
Overall health rating	0.2	0.4	0.6	0.5	0.7
Chest pain or discomfort	0.2	0.2	0.5	0.7	0.0
Medication: Aspirin	0.2	0.3	0.6	-0.2	0.8
Whole body fat-free mass	0.2	1.1	2.1	1.5	0.0
Average weekly red wine intake	0.2	0.4	0.5	0.5	0.7
Medication: Aspirin	0.2	0.2	0.4	0.2	0.6
Whole body water mass	0.2	1.1	2.2	1.5	-0.1
Leg predicted mass (right)	0.2	0.8	1.6	1.3	-0.3
Arm fat mass (left)	0.2	0.8	1.5	1.2	-0.4
Miserableness	0.2	0.4	0.6	-0.5	0.8
Wears glasses or contact lenses	0.2	0.2	0.4	-0.6	-0.3
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.1	0.6
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.2	0.7
Basal metabolic rate	0.2	1.2	2.4	1.5	-0.1
Leg fat percentage (left)	0.2	0.6	0.8	0.9	-0.6
Arm fat-free mass (left)	0.2	1.2	2.3	1.5	-0.2
Irritability	0.2	0.3	0.4	-0.7	0.3
Fractured/broken bones in last 5 years	0.2	0.3	0.6	0.0	0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	0.3	-0.7
Heart disease (siblings)	0.2	0.3	0.6	0.8	-0.0
Arm predicted mass (left)	0.2	0.9	1.8	1.3	0.2
Bipolar Disorder (2018)	0.1	0.1	0.1	0.3	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.4	-0.4	-0.6
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.5	0.0
Mean Putamen Volume	0.1	0.1	0.1	0.4	-0.4
Blood Eosinophil Count	0.1	1.0	1.2	1.1	-1.0
Blood Platelet Count	0.1	1.2	2.4	-0.0	-1.6
Height	0.1	2.8	3.5	-1.9	1.4
Hypothyroidism (self reported)	0.1	0.3	0.6	0.2	0.8
Respiratory disease	0.1	0.1	0.1	0.3	-0.4
Hair Pigment	0.1	3.2	3.4	-1.9	1.7
Relative age of first facial hair	0.1	0.3	0.4	-0.4	0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	0.6	-0.0
Leg fat-free mass (left)	0.1	0.8	1.4	1.2	-0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.1	-0.4	-0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.4	0.1
Leg predicted mass (left)	0.1	0.8	1.4	1.2	-0.4
Trunk fat mass	0.1	0.3	0.3	0.4	-0.6
Waist circumference	0.1	0.4	0.7	0.8	-0.2
Past tobacco smoking	0.1	0.3	0.4	-0.7	0.3
Qualifications: None of the above	0.1	0.2	0.3	0.6	0.3
Weight	0.1	0.5	1.0	1.0	0.0
Hip circumference	0.1	0.6	1.1	1.1	-0.1
Prospective memory result	0.1	0.1	0.1	-0.3	-0.1
Arm fat mass (right)	0.1	0.4	0.7	0.9	-0.1
Standing height	0.1	0.6	1.1	0.2	1.0
Leg fat percentage (right)	0.1	0.3	0.4	0.6	-0.6
Number of children fathered	0.1	0.2	0.2	0.3	-0.5
Pulse wave peak to peak time	0.1	0.1	0.2	0.4	0.3
Medication: Allopurinol	0.1	0.1	0.1	-0.4	-0.3
Medication: Seretide 50 evohaler	0.1	0.2	0.3	-0.5	0.2
Alcohol intake frequency.	0.1	0.3	0.6	-0.8	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.2	-0.4
Leg fat-free mass (right)	0.1	0.8	1.5	1.2	-0.2
Ever had bowel cancer screening	0.1	0.1	0.2	-0.2	0.5
Qualifications: nursing, teaching	0.1	0.1	0.2	0.4	-0.1
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.4	0.2
Eye problems/disorders: Cataract	0.1	0.1	0.1	0.4	-0.4
Back pain experienced in last month	0.1	0.2	0.2	0.4	0.5
Mineral and other dietary supplements	0.1	0.1	0.1	-0.3	0.2
Smoking status: Current	0.1	0.2	0.4	0.7	-0.2
Leg fat mass (left)	0.1	0.3	0.4	0.7	-0.3
Depression (Nagel 2018)	0.0	0.0	0.1	-0.3	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.1	0.1	-0.3	0.0
Tanning	0.0	0.1	0.1	-0.3	-0.0
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.1	-0.2
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.1	-0.2
Medication: Metformin	0.0	0.1	0.1	0.2	-0.2
Trunk fat percentage	0.0	0.1	0.2	-0.1	-0.5
Maternal smoking around birth	0.0	0.0	0.0	-0.0	0.1
Sitting height	0.0	0.2	0.4	0.6	0.3
Mouth/teeth dental problems	0.0	0.1	0.1	-0.2	0.3
Diabetes (self-reported)	0.0	0.0	0.0	-0.2	-0.1
Fluid intelligence score	0.0	0.0	0.0	-0.1	-0.1
Arm fat percentage (right)	0.0	0.0	0.0	0.0	0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.0	-0.0	0.2
Asthma	0.0	0.1	0.1	-0.2	-0.3
Medication: Lansoprazole	0.0	0.0	0.0	-0.1	0.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.1	-0.1	0.3
Gout (self-reported)	0.0	0.0	0.0	-0.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	0.0	0.4
Birth weight	0.0	0.1	0.2	0.4	-0.1
Body fat percentage	0.0	0.1	0.2	0.0	-0.4
Comparative body size at age 10	0.0	0.0	0.0	-0.1	0.1
Whole body fat mass	0.0	0.2	0.3	0.5	-0.3
Leg fat mass (right)	0.0	0.2	0.2	0.5	-0.3
Had major operations	0.0	0.0	0.0	-0.1	-0.1
Illnesses of siblings: Diabetes	0.0	0.0	0.0	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.0	-0.1	0.1
Arm fat percentage (left)	0.0	0.2	0.2	0.5	-0.3
Diabetes diagnosed by doctor	0.0	0.1	0.1	-0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.0	0.1	0.2
Asthma (self-reported)	0.0	0.1	0.1	-0.3	-0.2
Medication: Gliclazide	0.0	0.0	0.0	0.2	-0.2
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	-0.2	0.1

Hub : Genes

SERINC1

Models

Trait associations