Hub : Genes

SERINC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.0880 0.043 0.0093 -0.004 NA 0.009 NA -0.004 9.4e-01 NA 6.9e-02 NA 1.0e+00
2 YFS Blood 0.0573 0.013 0.0000 0.046 0.079 0.079 0.08 0.079 8.6e-15 2e-24 1.5e-24 8.7e-25 1.5e-24

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.1 0.1 0.3 0.3
Bipolar Disorder or Schizophrenia 0.3 0.7 0.9 0.9 -0.8
Depressed Affect (Nagel 2018) 0.3 0.7 0.7 -0.8 0.9
Depression (Nagel 2018) 0.0 0.0 0.1 -0.3 0.0
Intelligence (Savage-Jansen 2018) 0.2 0.5 0.9 0.9 -0.4
Neuroticism (Nagel 2018) 1.4 3.2 3.9 -2.0 1.6
Schizophrenia (2018) 0.6 1.2 1.4 1.0 -1.2
Schizophrenia vs Biploar Disorder 1.8 2.4 2.6 1.6 -1.5
Worry (Nagel 2018) 1.8 3.8 5.3 -2.3 1.5
Alzheimer’s Disease (in mother) 0.9 1.1 1.6 0.7 -1.3
Alzheimer’s Disease (in father) 0.2 0.3 0.4 0.6 -0.3
Alzheimer’s Disease (including proxy) 0.5 0.7 1.0 0.6 -1.0
Crohns Disease (2017) 5.3 11.6 13.2 -3.2 3.6
Irritable Bowel Disease (IBD) 4.3 10.3 10.8 -3.1 3.3
Ulcerative Colitis (UC) 2.0 3.8 5.3 -2.3 1.5
Major Depression (MDD) 0.6 0.8 0.9 -0.9 0.8
Reaction Time 0.6 1.2 1.6 -1.2 -0.9
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.4 -0.4 -0.6
Breast Cancer 0.9 2.2 4.5 -2.1 0.1
Ovarian Cancer 0.3 0.3 0.7 -0.8 0.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.0 1.4 1.9 -1.4 -0.9
Bipolar Disorder (2011) 1.8 1.7 2.9 -1.7 0.8
Body Mass Index (BMI) (2010) 0.1 0.1 0.3 -0.5 0.0
Coronary Artery Disease (CAD) 0.3 0.3 0.6 -0.8 -0.3
Crohns Disease (2012) 2.0 3.2 5.3 -1.1 2.3
Mean Putamen Volume 0.1 0.1 0.1 0.4 -0.4
Fasting Glucose 0.3 0.4 0.6 0.4 0.8
HbA1C 0.0 0.1 0.1 -0.3 0.0
HDL Cholesterol 0.2 0.3 0.5 -0.2 0.7
LDL Cholesterol 0.2 0.3 0.5 -0.1 0.7
Lupus 0.2 0.3 0.5 -0.0 -0.7
Neuroticism (2016) 1.9 2.7 4.6 -0.9 2.1
Primary Biliary Cirrhosis 0.2 0.3 0.4 0.7 -0.4
Rheumatoid Arthritis 1.7 2.3 3.0 -1.7 1.3
Schizophrenia (2014) 0.4 0.9 1.0 1.0 -0.9
Triglycerides 0.6 0.9 1.5 -0.6 1.2
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.6 1.3 0.1
Ulcerative Colitis 0.5 0.7 1.0 -1.0 0.7
Blood Eosinophil Count 0.1 1.0 1.2 1.1 -1.0
Blood Platelet Count 0.1 1.2 2.4 -0.0 -1.6
Blood Red Count 3.0 28.7 46.6 3.3 -6.8
Blood White Count 0.2 1.6 2.9 -1.7 0.5
Heel T-Score 0.3 2.0 2.0 1.4 -1.4
BMI 0.4 2.2 4.4 2.1 0.4
Height 0.1 2.8 3.5 -1.9 1.4
Waist Hip Ratio (WHR) 0.4 1.8 2.6 1.0 -1.6
Systolic Blood Pressure 0.2 0.8 1.4 0.4 1.2
Smoking Status 0.7 1.7 1.8 1.3 -1.3
Allergy or Eczema 4.4 11.7 15.4 3.9 -2.8
Cardiovascular Disease 2.0 6.5 12.8 -0.5 3.6
Hypothyroidism (self reported) 0.1 0.3 0.6 0.2 0.8
Respiratory disease 0.1 0.1 0.1 0.3 -0.4
Type 2 Diabetes (T2D) (2018) 0.3 0.6 0.9 1.0 0.5
Lung FEV1/FVC ratio 0.2 0.8 0.9 0.9 -0.9
Lung FVC 1.7 8.5 13.9 -1.8 3.7
Neuroticism 1.4 3.5 3.6 -1.8 1.9
Chronotype (morning person) 0.2 0.5 0.9 -0.0 -1.0
Hair Pigment 0.1 3.2 3.4 -1.9 1.7
Tanning 0.0 0.1 0.1 -0.3 -0.0
Hand grip strength (left) 1.5 3.9 5.1 1.6 -2.3
Number of treatments/medications taken 2.5 4.5 8.7 -0.5 3.0
Average weekly spirits intake 0.4 0.5 0.9 -0.2 -1.0
Sensitivity / hurt feelings 2.1 3.5 6.2 -0.9 2.5
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.0 -0.1 -0.2
Hearing difficulty/problems: Yes 3.7 5.6 9.9 1.2 -3.1
Relative age of first facial hair 0.1 0.3 0.4 -0.4 0.6
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.3 0.6 -0.0
Ever used hormone-replacement therapy (HRT) 1.3 1.7 2.1 1.4 -1.1
Ever had hysterectomy (womb removed) 1.2 1.4 2.4 1.6 -0.6
Systolic blood pressure, automated reading 0.3 0.9 1.5 1.2 0.5
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 0.1 -0.2
Angina 0.4 0.5 0.8 0.4 -0.9
Medication for hormone replacement therapy 1.4 1.5 2.9 -0.4 1.7
Vitamin and mineral supplements 0.7 1.0 1.9 0.3 -1.4
Supplements: Zinc 0.6 0.7 1.0 -1.0 0.6
Medication: Co-codamol 4.5 5.3 6.7 -2.0 2.6
Medication: Metformin 0.0 0.1 0.1 0.2 -0.2
Diabetes (father) 3.2 4.0 5.0 -2.2 1.7
Diabetes (mother) 3.1 4.0 7.7 -0.5 2.8
Severe depression (siblings) 0.9 1.1 1.1 1.1 -1.0
Pack years adult smoking proportion 0.7 1.0 1.4 -0.8 1.2
Impedance of leg (right) 0.3 1.2 1.4 -1.2 1.0
Leg fat-free mass (left) 0.1 0.8 1.4 1.2 -0.4
Trunk fat percentage 0.0 0.1 0.2 -0.1 -0.5
Hand grip strength (right) 2.3 6.3 7.8 2.2 -2.8
Townsend deprivation index at recruitment 0.3 0.4 0.8 -0.9 0.2
Current tobacco smoking 0.3 0.6 0.7 0.9 -0.6
Average weekly fortified wine intake 0.5 0.6 1.1 1.0 -0.3
Maternal smoking around birth 0.0 0.0 0.0 -0.0 0.1
Fed-up feelings 1.4 2.5 4.4 -0.8 2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 0.6 -0.6 0.8
Relative age voice broke 0.8 1.2 2.1 -0.5 1.5
Taking other prescription medications 0.3 0.4 0.9 -0.0 0.9
Age when periods started (menarche) 0.6 1.4 2.6 0.5 -1.6
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 1.2 0.3 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.3 -1.5 0.5
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 1.7 -1.3 0.9
Qualifications: CSEs or equivalent 0.1 0.1 0.1 -0.4 -0.1
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.4 0.1
High blood pressure 1.5 4.1 7.4 -0.9 2.7
Hayfever, allergic rhinitis or eczema 3.3 7.2 8.1 2.9 -2.5
Multivitamins +/- minerals 0.4 0.5 0.9 -0.4 1.0
Stomach or abdominal pain in last month 0.9 1.2 1.2 -1.1 1.1
Supplements: Glucosamine 1.0 1.3 2.3 1.5 -0.6
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 0.8 0.5 0.9
Medication: Atenolol 2.6 3.2 4.2 -1.5 2.0
Medication: Levothyroxine sodium 0.2 0.4 0.4 0.7 0.6
Sitting height 0.0 0.2 0.4 0.6 0.3
Chronic bronchitis/emphysema (father) 0.6 0.8 1.3 -1.1 -0.4
High blood pressure (mother) 1.1 1.6 2.0 1.1 1.4
Body mass index (BMI) 0.2 0.6 1.1 1.0 -0.5
Impedance of leg (left) 0.2 1.1 1.2 -1.1 1.0
Leg predicted mass (left) 0.1 0.8 1.4 1.2 -0.4
Trunk fat mass 0.1 0.3 0.3 0.4 -0.6
Waist circumference 0.1 0.4 0.7 0.8 -0.2
Number of incorrect matches in round 1.5 2.5 3.1 -1.3 1.8
Past tobacco smoking 0.1 0.3 0.4 -0.7 0.3
Alcohol usually taken with meals 1.1 1.8 2.8 1.7 -0.9
Nervous feelings 2.6 4.9 5.9 -2.0 2.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.7 -0.8 0.1
Hearing difficulty/problems with background noise 2.0 3.1 4.4 1.4 -2.1
Hair/balding pattern: Pattern 2 1.9 2.4 4.5 2.1 -0.5
Had menopause 1.5 1.9 3.4 0.6 -1.8
Had other major operations 0.7 0.8 1.6 0.0 -1.3
Forced vital capacity (FVC) 0.6 2.3 4.5 0.2 2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.0 -1.0 -0.1
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 2.6 -1.6 -0.2
Qualifications: None of the above 0.1 0.2 0.3 0.6 0.3
Financial difficulties in last 2 years 0.3 0.4 0.9 0.9 0.1
Mouth/teeth dental problems 0.0 0.1 0.1 -0.2 0.3
Heart attack 0.2 0.2 0.3 0.3 -0.6
Allergy 1.1 2.5 3.6 -1.9 1.2
Pain all over the body in last month 0.8 0.9 0.9 0.9 -1.0
Diabetes (self-reported) 0.0 0.0 0.0 -0.2 -0.1
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.0 0.5 -1.0
Medication: Ramipril 0.6 0.8 1.6 1.3 0.0
Medication: Simvastatin 5.3 7.8 8.9 -2.6 3.0
Fluid intelligence score 0.0 0.0 0.0 -0.1 -0.1
Illnesses of siblings 0.2 0.3 0.6 -0.8 -0.2
Neuroticism score 1.7 3.5 3.7 -1.9 1.8
Weight 0.1 0.5 1.0 1.0 0.0
Impedance of arm (right) 0.8 3.8 6.5 -2.5 1.1
Arm fat percentage (right) 0.0 0.0 0.0 0.0 0.2
Trunk fat-free mass 0.3 1.5 2.9 1.7 0.1
Hip circumference 0.1 0.6 1.1 1.1 -0.1
Time employed in main current job 0.6 0.6 1.0 1.0 0.5
Alcohol intake versus 10 years previously 0.2 0.2 0.5 -0.2 -0.7
Father’s age at death 0.5 0.6 1.1 1.1 0.4
Worrier / anxious feelings 3.1 5.8 8.0 -1.9 2.8
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 3.0 -0.5 1.7
Falls in the last year 0.6 0.8 1.7 -1.3 -0.1
Hair/balding pattern: Pattern 3 3.5 5.2 9.9 -3.1 0.8
Number of live births 1.9 2.7 5.0 2.2 0.6
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.5 0.6 1.2
Pulse rate 2.4 4.0 7.2 0.9 -2.7
Happiness 4.4 5.3 7.8 -2.8 1.7
Noisy workplace 6.7 8.2 14.9 1.3 -3.9
Qualifications: A levels/AS levels or equivalent 0.0 0.0 0.0 -0.0 0.2
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.2 0.2 -1.5
Mouth/teeth dental problems: Dentures 0.5 0.8 1.3 -1.1 0.5
Asthma 0.0 0.1 0.1 -0.2 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 3.8 1.0 -1.9
Medication: Cholesterol lowering 3.0 4.6 5.9 -1.8 2.4
Depression (self-reported) 0.4 0.5 0.7 -0.8 0.5
Medication: Lansoprazole 0.0 0.0 0.0 -0.1 0.0
Prospective memory result 0.1 0.1 0.1 -0.3 -0.1
Lung cancer (father) 1.5 1.7 3.0 0.7 -1.7
Illnesses of mother 0.3 0.4 0.5 -0.6 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.0 -0.2 1.4
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 -0.6 -0.3
Impedance of arm (left) 0.4 1.9 3.5 -1.9 0.6
Arm fat mass (right) 0.1 0.4 0.7 0.9 -0.1
Trunk predicted mass 0.3 1.5 3.0 1.7 0.2
Standing height 0.1 0.6 1.1 0.2 1.0
Length of working week for main job 2.6 2.9 5.6 0.3 -2.4
Exposure to tobacco smoke at home 1.4 1.6 3.1 1.8 -0.3
Breastfed as a baby 1.3 1.6 3.3 -0.2 -1.8
Tense / ‘highly strung’ 2.3 3.9 5.6 -2.4 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 4.5 -2.1 1.7
Hair/balding pattern: Pattern 4 0.3 0.7 1.4 1.2 -0.1
Birth weight of first child 0.3 0.6 1.0 -0.4 -1.0
Peak expiratory flow (PEF) 0.4 1.0 1.6 0.6 1.3
Pulse wave reflection index 0.6 0.8 1.5 -1.2 -0.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.5 0.0 -0.7
Loud music exposure frequency 1.0 1.1 2.1 -1.5 0.2
Qualifications: O levels/GCSEs or equivalent 0.0 0.1 0.1 -0.1 0.3
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 1.4 1.0 -1.2
Blood clot in the leg (DVT) 1.7 2.1 2.8 -1.2 1.7
Medication: Paracetamol 2.4 3.9 6.7 1.1 2.6
Headache pain in last month 0.3 0.5 0.8 0.9 -0.5
Medication for cholesterol, blood pressure or diabetes 3.0 5.0 8.0 1.4 -2.8
Glaucoma (self-reported) 0.3 0.3 0.7 -0.0 0.8
Gout (self-reported) 0.0 0.0 0.0 -0.1 0.1
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.1 0.0 0.4
Medication: Amlodipine 0.3 0.4 0.6 -0.5 0.8
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.1 0.2 1.1
Birth weight 0.0 0.1 0.2 0.4 -0.1
Chronic bronchitis/emphysema (mother) 1.5 1.8 3.5 -0.1 -1.9
High blood pressure (siblings) 0.2 0.3 0.4 0.6 0.6
Forced vital capacity (FVC), Best measure 0.7 2.5 4.7 -0.6 2.2
Body fat percentage 0.0 0.1 0.2 0.0 -0.4
Leg fat percentage (right) 0.1 0.3 0.4 0.6 -0.6
Arm fat-free mass (right) 0.4 1.9 3.6 1.9 -0.4
Exposure to tobacco smoke outside home 2.3 3.0 3.8 2.0 -1.5
Comparative body size at age 10 0.0 0.0 0.0 -0.1 0.1
Number of full brothers 1.2 1.5 2.2 -0.9 -1.5
Worry too long after embarrassment 1.3 2.2 3.8 -1.9 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.6 -1.6 -0.0
Wheeze or whistling in the chest in last year 0.9 1.6 3.1 -0.0 -1.8
Number of children fathered 0.1 0.2 0.2 0.3 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 4.0 0.8 2.0
Age at first live birth 0.5 0.8 0.9 -0.9 1.0
Pulse wave peak to peak time 0.1 0.1 0.2 0.4 0.3
Health satisfaction 1.2 1.5 2.7 -1.6 0.6
Shortness of breath walking on level ground 2.0 2.4 3.2 -1.8 -1.2
Qualifications: College or University degree 0.2 0.7 1.0 -0.7 -1.0
Eye problems/disorders: None of the above 0.6 0.7 1.0 -1.0 0.6
Mouth/teeth dental problems: Loose teeth 1.1 1.3 1.6 -1.3 -1.0
Emphysema/chronic bronchitis 0.6 0.6 1.2 -0.2 1.1
Medication for pain relief, constipation, heartburn 1.1 1.9 2.6 -1.1 -1.6
Neck or shoulder pain in last month 0.2 0.3 0.4 0.5 -0.6
Medication: Blood pressure 1.2 2.1 4.2 -0.3 2.1
Angina (self-reported) 0.3 0.4 0.6 0.4 -0.8
Migraine (self-reported) 1.0 1.2 1.8 0.7 -1.3
Medication: Ibuprofen 4.1 4.9 8.0 1.3 -2.8
Medication: Allopurinol 0.1 0.1 0.1 -0.4 -0.3
Medication: Omeprazole 0.5 0.6 1.1 -0.3 1.1
Medication: Seretide 50 evohaler 0.1 0.2 0.3 -0.5 0.2
Mean time to correctly identify matches 0.4 0.8 1.4 -1.2 -0.5
Heart disease (mother) 2.6 3.1 4.5 -2.1 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 1.4 1.2 -1.1
Whole body fat mass 0.0 0.2 0.3 0.5 -0.3
Leg fat mass (right) 0.0 0.2 0.2 0.5 -0.3
Arm predicted mass (right) 0.4 2.3 4.4 2.1 -0.3
Pulse rate, automated reading 2.5 8.2 11.7 2.2 -3.4
Alcohol intake frequency. 0.1 0.3 0.6 -0.8 0.1
Comparative height size at age 10 0.2 1.0 1.9 -0.3 1.4
Number of full sisters 0.6 0.7 0.7 -0.8 0.9
Suffer from ‘nerves’ 1.9 3.0 3.2 -1.8 1.7
Overall health rating 0.2 0.4 0.6 0.5 0.7
Chest pain or discomfort 0.2 0.2 0.5 0.7 0.0
Had major operations 0.0 0.0 0.0 -0.1 -0.1
Age at last live birth 0.5 0.7 1.3 0.1 1.1
Family relationship satisfaction 0.8 1.0 1.3 -1.1 -0.8
Leg pain on walking 1.0 1.2 2.3 0.3 -1.5
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.0 -0.5 -1.4
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.5 -0.1 -1.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.5 -0.7 -0.6
Medication: Aspirin 0.2 0.3 0.6 -0.2 0.8
Supplements: Vitamin C 1.5 1.8 3.5 -1.9 0.3
Knee pain experienced in last month 1.1 1.8 2.9 1.7 -0.8
Hypertension (Self-reported) 1.6 4.3 8.6 -0.3 2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 0.2 -0.4
Illnesses of father: Heart disease 0.7 1.0 1.3 -1.1 0.9
Illnesses of siblings: Diabetes 0.0 0.0 0.0 -0.1 -0.1
Smoking status: Previous 0.3 0.4 0.4 0.6 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.0 -0.1 0.1
Whole body fat-free mass 0.2 1.1 2.1 1.5 0.0
Leg fat-free mass (right) 0.1 0.8 1.5 1.2 -0.2
Arm fat percentage (left) 0.0 0.2 0.2 0.5 -0.3
Average weekly red wine intake 0.2 0.4 0.5 0.5 0.7
Handedness (chirality/laterality): Left-handed 1.5 1.8 3.3 -0.4 1.8
Mood swings 0.7 1.3 1.8 -0.9 1.3
Loneliness, isolation 0.3 0.4 0.8 -0.2 0.9
Long-standing illness, disability or infirmity 0.5 0.7 1.5 0.2 1.2
Ever had bowel cancer screening 0.1 0.1 0.2 -0.2 0.5
Diabetes diagnosed by doctor 0.0 0.1 0.1 -0.3 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.2 4.2 2.1 -0.2
Friendships satisfaction 1.1 1.3 1.4 -1.1 -1.2
Qualifications: nursing, teaching 0.1 0.1 0.2 0.4 -0.1
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.4 0.2
Eye problems/disorders: Cataract 0.1 0.1 0.1 0.4 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.0 0.1 0.2
Medication for cholesterol 1.4 2.1 3.5 0.8 -1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 1.9 -0.3 1.4
Back pain experienced in last month 0.1 0.2 0.2 0.4 0.5
Mineral and other dietary supplements 0.1 0.1 0.1 -0.3 0.2
Breast cancer (self-reported) 0.5 0.6 1.0 0.3 1.0
Asthma (self-reported) 0.0 0.1 0.1 -0.3 -0.2
Osteoporosis (self-reported) 1.0 1.2 2.5 1.6 0.0
Osteoarthritis (self-reported) 0.5 0.6 1.2 -1.1 -0.1
Medication: Aspirin 0.2 0.2 0.4 0.2 0.6
Medication: Gliclazide 0.0 0.0 0.0 0.2 -0.2
Illnesses of father: None of the above (group 1) 0.8 1.0 1.1 1.0 -1.0
Smoking status: Current 0.1 0.2 0.4 0.7 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 2.4 -1.1 1.5
Whole body water mass 0.2 1.1 2.2 1.5 -0.1
Leg predicted mass (right) 0.2 0.8 1.6 1.3 -0.3
Arm fat mass (left) 0.2 0.8 1.5 1.2 -0.4
Number of self-reported non-cancer illnesses 0.4 0.6 1.2 -0.2 1.1
Average weekly champagne plus white wine intake 0.4 0.6 0.6 0.8 -0.7
Miserableness 0.2 0.4 0.6 -0.5 0.8
Guilty feelings 1.1 1.7 1.9 -1.2 1.4
Wears glasses or contact lenses 0.2 0.2 0.4 -0.6 -0.3
Ever taken oral contraceptive pill 0.5 0.6 1.1 -1.1 0.2
Hearing aid user 1.5 1.7 2.2 1.5 -1.1
Mother’s age at death 1.3 1.6 3.2 1.8 0.2
Financial situation satisfaction 2.0 2.5 3.5 -1.2 1.9
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.2 0.1 -1.1
Commuting to job workplace: Public transport 0.2 0.2 0.3 0.1 0.6
Eye problems/disorders: Glaucoma 0.6 0.7 1.5 -0.1 1.2
Medication: Blood pressure 0.9 1.6 2.0 -1.1 1.4
Pain type(s) experienced in last month: Hip pain 1.6 2.0 3.4 1.8 -0.8
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.0 -0.2 0.1
High cholesterol (Self-reported) 2.5 4.5 6.1 -2.5 1.7
Medication: Bendroflumethiazide 1.4 2.1 2.6 -1.6 1.3
Medication: Paracetamol 1.4 2.2 3.5 1.0 1.9
Medication: Lisinopril 2.1 2.7 2.8 -1.6 1.7
Medication: Atorvastatin 0.5 0.6 0.7 -0.7 0.8
Illnesses of father: High blood pressure 0.2 0.3 0.5 0.2 0.7
Alcohol drinker status: Never 0.4 0.5 0.6 -0.7 0.8
Ever smoked 0.3 0.6 1.1 1.1 -0.3
Basal metabolic rate 0.2 1.2 2.4 1.5 -0.1
Leg fat percentage (left) 0.2 0.6 0.8 0.9 -0.6
Arm fat-free mass (left) 0.2 1.2 2.3 1.5 -0.2
Number of operations (self-reported) 0.8 1.2 2.4 -1.5 -0.0
Average weekly beer plus cider intake 0.8 1.1 1.6 -1.3 0.9
Irritability 0.2 0.3 0.4 -0.7 0.3
Risk taking 4.3 6.4 10.4 1.5 -3.2
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.6 0.8 0.1
Fractured/broken bones in last 5 years 0.2 0.3 0.6 0.0 0.8
Age started oral contraceptive pill 1.1 1.4 2.2 -1.5 -0.7
Diastolic blood pressure, automated reading 0.6 1.9 2.3 1.5 -1.3
Ever depressed for a whole week 0.4 0.5 0.9 -1.0 0.3
Unable to work because of sickness or disability 0.9 1.2 2.1 -0.6 1.4
Commuting to job workplace: Cycle 0.8 1.0 1.8 -1.3 0.3
Myopia 0.5 0.8 1.4 0.4 -1.2
Vascular/heart problems diagnosed by doctor 1.5 4.0 6.9 1.0 -2.6
Cholesterol lowering medication 1.5 2.2 2.2 -1.5 1.5
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 1.7 -1.3 1.0
Pain experienced in last month 0.7 1.1 1.3 -1.1 1.0
Supplements: Calcium 3.4 3.8 7.2 -0.5 2.7
Basal cell carcinoma (self-reported) 1.7 2.0 2.7 -1.6 1.1
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.5 0.3 -0.7
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 1.6 -1.2 1.3
Heart disease (siblings) 0.2 0.3 0.6 0.8 -0.0
Alcohol drinker status: Previous 1.4 1.6 2.9 -1.7 0.6
Pack years of smoking 0.5 0.7 0.9 -0.9 0.8
Impedance of whole body 0.5 2.3 3.8 -2.0 0.9
Leg fat mass (left) 0.1 0.3 0.4 0.7 -0.3
Arm predicted mass (left) 0.2 0.9 1.8 1.3 0.2