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chr6:108,612,536-112,621,834

Best TWAS P=3.09e-136 · Best GWAS P=1.28e-204 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	GTEx	Cells Transformed fibroblasts	CD164	0.14	0.07	lasso	6	0.05	1.9e-04	-27.48	-24.8	3.1e-136	0.83	0.90	0.03	TRUE
82	The Cancer Genome Atlas	Esophageal Carcinoma	C6orf182	0.10	-0.01	blup	40	0.03	4.2e-02	-25.16	-23.7	2.4e-124	0.58	0.01	0.58	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CD164	0.11	0.07	blup	376	0.10	1.6e-12	-7.42	16.8	1.1e-63	-0.40	1.00	0.00	TRUE
39	GTEx	Muscle Skeletal	RP11-425D10.10	0.16	0.11	enet	24	0.14	2.9e-13	5.78	8.1	4.1e-16	-0.19	1.00	0.00	TRUE
47	GTEx	Skin Not Sun Exposed Suprapubic	KIAA1919	0.11	0.06	lasso	6	0.07	1.8e-04	-7.20	-7.9	3.7e-15	0.06	0.04	0.96	TRUE
35	GTEx	Lung	KIAA1919	0.13	0.06	enet	16	0.11	1.4e-08	-7.97	-7.5	6.6e-14	0.01	0.03	0.97	TRUE
76	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KIAA1919	0.09	0.05	blup	50	0.08	2.6e-07	-6.56	-6.9	4.2e-12	0.04	0.04	0.95	TRUE
45	GTEx	Pituitary	KIAA1919	0.24	0.28	lasso	6	0.26	3.3e-07	-6.56	-6.9	4.3e-12	0.04	0.06	0.90	TRUE
81	The Cancer Genome Atlas	Colon Adenocarcinoma	SMPD2	0.17	0.14	lasso	4	0.14	2.3e-08	-7.42	-6.9	4.5e-12	0.24	0.99	0.00	TRUE
46	GTEx	Pituitary	RP5-1112D6.4	0.23	0.16	lasso	4	0.13	4.4e-04	-6.87	-6.3	2.6e-10	-0.01	0.19	0.11	TRUE
83	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMPD2	0.09	0.09	blup	42	0.10	2.1e-11	-5.09	-6.2	7.0e-10	0.20	1.00	0.00	TRUE
71	ROSMAP	Brain Pre-frontal Cortex	TRAF3IP2-AS1	0.24	0.30	bslmm	421	0.30	1.3e-38	-5.89	-6.2	7.6e-10	0.04	1.00	0.00	TRUE
17	GTEx	Brain Hypothalamus	GTF3C6	0.32	0.04	lasso	4	0.08	6.8e-03	-4.53	5.2	1.8e-07	0.00	0.10	0.10	TRUE
78	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMPD2	0.04	0.07	lasso	4	0.07	8.8e-14	-5.07	-5.2	1.8e-07	0.19	1.00	0.00	TRUE
37	GTEx	Muscle Skeletal	CD164	0.07	0.07	enet	15	0.06	3.7e-06	17.47	20.9	3.1e-97	-0.67	0.98	0.01	FALSE
63	NTR	Blood	CD164	0.01	0.00	bslmm	372	0.00	2.0e-02	4.07	-20.1	1.2e-89	0.58	0.08	0.62	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	CD164	0.07	0.01	enet	16	0.05	1.6e-07	-5.09	17.7	2.9e-70	-0.45	0.72	0.14	FALSE
72	YFS	Blood	CD164	0.03	0.01	blup	382	0.02	1.9e-07	17.47	-17.6	1.6e-69	0.57	0.98	0.02	FALSE
52	GTEx	Stomach	SMPD2	0.14	-0.01	lasso	5	-0.01	8.6e-01	-6.08	-14.6	5.1e-48	0.46	0.06	0.21	FALSE
3	GTEx	Adipose Subcutaneous	SMPD2	0.14	0.10	lasso	10	0.12	2.3e-10	-5.10	-13.6	2.2e-42	0.46	0.97	0.03	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	CD164	0.03	0.01	blup	49	0.01	2.1e-02	-5.10	-13.5	1.2e-41	0.44	0.07	0.18	FALSE
36	GTEx	Muscle Skeletal	FIG4	0.20	0.11	enet	19	0.11	4.8e-11	-6.51	-11.7	1.3e-31	0.33	1.00	0.00	FALSE
73	YFS	Blood	FIG4	0.04	0.04	blup	478	0.04	2.7e-13	-5.50	-10.3	7.8e-25	0.32	1.00	0.00	FALSE
21	GTEx	Cells Transformed fibroblasts	AK9	0.14	0.17	lasso	4	0.15	2.4e-11	9.51	9.5	2.9e-21	-0.32	1.00	0.00	FALSE
12	GTEx	Artery Coronary	RP11-425D10.10	0.31	0.00	enet	20	0.01	1.3e-01	6.00	-9.4	4.5e-21	0.34	0.04	0.05	FALSE
8	GTEx	Artery Aorta	AK9	0.16	0.14	enet	32	0.14	3.7e-08	8.95	9.4	4.9e-21	-0.35	1.00	0.00	FALSE
13	GTEx	Brain Cerebellum	PPIL6	0.30	0.14	lasso	13	0.11	3.5e-04	7.13	-9.3	8.8e-21	0.19	0.11	0.05	FALSE
31	GTEx	Esophagus Muscularis	SMPD2	0.10	0.05	enet	13	0.05	2.9e-04	-6.08	-8.9	5.2e-19	0.26	0.35	0.08	FALSE
95	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SMPD2	0.10	0.04	lasso	2	0.07	1.2e-03	-7.42	-8.9	7.6e-19	0.26	0.05	0.08	FALSE
2	GTEx	Adipose Subcutaneous	FIG4	0.12	0.08	lasso	4	0.07	4.4e-06	8.85	8.6	5.8e-18	-0.32	0.96	0.00	FALSE
25	GTEx	Colon Sigmoid	AK9	0.13	0.06	enet	32	0.13	3.1e-05	-1.45	-8.2	2.3e-16	0.18	0.47	0.04	FALSE
88	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMPD2	0.12	0.02	enet	7	0.08	1.9e-09	-5.04	-8.2	3.5e-16	0.23	0.87	0.05	FALSE
55	GTEx	Testis	MICAL1	0.28	0.02	enet	25	0.02	4.2e-02	-4.00	-7.8	6.1e-15	0.22	0.16	0.04	FALSE
51	GTEx	Spleen	RP11-425D10.10	0.17	0.04	enet	26	0.12	4.7e-04	-2.43	-7.8	6.8e-15	0.33	0.24	0.17	FALSE
89	The Cancer Genome Atlas	Lung Adenocarcinoma	KIAA1919	0.11	0.12	blup	50	0.13	4.1e-15	-7.67	-7.8	8.4e-15	0.02	0.03	0.97	FALSE
101	The Cancer Genome Atlas	Skin Cutaneous Melanoma	KIAA1919	0.18	0.08	blup	49	0.16	5.2e-05	-8.04	-7.8	9.4e-15	0.03	0.01	0.93	FALSE
9	GTEx	Artery Aorta	KIAA1919	0.14	0.12	lasso	5	0.11	1.6e-06	-6.87	-7.7	1.0e-14	0.02	0.08	0.90	FALSE
100	The Cancer Genome Atlas	Soft Tissue Sarcoma	KIAA1919	0.06	0.06	enet	4	0.05	4.2e-04	-7.67	-7.7	1.0e-14	0.01	0.02	0.66	FALSE
74	YFS	Blood	SESN1	0.10	0.12	lasso	15	0.12	1.4e-36	7.51	7.7	1.1e-14	-0.09	1.00	0.00	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIAA1919	0.18	0.19	lasso	3	0.20	4.6e-21	-6.87	-7.7	1.5e-14	0.01	0.23	0.77	FALSE
22	GTEx	Cells Transformed fibroblasts	KIAA1919	0.22	0.23	lasso	5	0.24	5.5e-18	-6.87	-7.7	1.6e-14	0.02	0.86	0.14	FALSE
92	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	KIAA1919	0.13	0.08	blup	50	0.12	1.8e-08	-6.87	-7.7	1.9e-14	0.02	0.07	0.93	FALSE
105	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA1919	0.20	0.23	lasso	7	0.25	8.0e-24	-6.87	-7.6	2.7e-14	0.01	0.13	0.87	FALSE
102	The Cancer Genome Atlas	Stomach Adenocarcinoma	KIAA1919	0.12	0.11	lasso	3	0.15	7.9e-11	-6.87	-7.6	2.9e-14	0.02	0.15	0.85	FALSE
14	GTEx	Brain Cerebellum	RP5-1112D6.4	0.20	-0.01	lasso	8	-0.01	8.4e-01	-7.20	7.6	3.8e-14	-0.02	0.04	0.46	FALSE
80	The Cancer Genome Atlas	Colon Adenocarcinoma	KIAA1919	0.19	0.13	lasso	4	0.16	2.5e-09	-6.87	-7.5	8.3e-14	0.02	0.14	0.85	FALSE
15	GTEx	Brain Cortex	AK9	0.21	0.03	enet	29	0.16	3.2e-05	-2.03	7.5	8.8e-14	-0.32	0.57	0.08	FALSE
7	GTEx	Adrenal Gland	RP11-425D10.10	0.11	0.00	enet	11	0.02	4.9e-02	-7.15	-7.4	1.0e-13	0.23	0.15	0.33	FALSE
65	NTR	Blood	SESN1	0.03	0.04	lasso	3	0.03	5.4e-11	7.43	7.4	1.1e-13	-0.09	1.00	0.00	FALSE
97	The Cancer Genome Atlas	Prostate Adenocarcinoma	SESN1	0.02	0.04	lasso	4	0.04	1.1e-04	7.40	7.4	1.3e-13	-0.09	0.10	0.80	FALSE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MICAL1	0.04	0.01	blup	51	0.02	6.3e-03	6.87	7.4	1.8e-13	-0.13	0.06	0.04	FALSE
90	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA1919	0.11	0.03	lasso	2	0.04	1.8e-05	-6.87	-7.3	2.0e-13	0.01	0.14	0.83	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	CCDC162P	0.10	0.04	bslmm	398	0.07	1.1e-09	-19.72	7.3	2.4e-13	-0.45	0.92	0.04	FALSE
93	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	KIAA1919	0.26	0.14	blup	49	0.18	3.2e-08	-7.67	-7.3	2.4e-13	0.03	0.01	0.97	FALSE
44	GTEx	Pancreas	KIAA1919	0.15	0.04	enet	13	0.08	2.2e-04	-5.19	-7.3	3.1e-13	0.04	0.08	0.73	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	SMPD2	0.11	0.06	lasso	6	0.06	4.1e-03	-7.57	-7.3	3.3e-13	0.25	0.36	0.04	FALSE
6	GTEx	Adrenal Gland	KIAA1919	0.20	0.07	enet	15	0.09	3.6e-04	2.86	-7.2	4.3e-13	0.04	0.10	0.58	FALSE
56	GTEx	Testis	KIAA1919	0.23	0.22	lasso	3	0.23	2.2e-10	-6.87	-7.2	4.3e-13	0.01	0.70	0.29	FALSE
42	GTEx	Nerve Tibial	KIAA1919	0.11	0.03	enet	19	0.05	3.5e-04	-6.56	-7.2	4.5e-13	0.05	0.13	0.78	FALSE
11	GTEx	Artery Coronary	AK9	0.27	0.26	enet	18	0.28	5.2e-10	8.79	7.2	4.6e-13	-0.26	1.00	0.00	FALSE
58	GTEx	Thyroid	KIAA1919	0.16	0.05	enet	14	0.08	1.8e-06	-6.38	-7.2	5.4e-13	0.03	0.30	0.69	FALSE
23	GTEx	Cells Transformed fibroblasts	RP5-1112D6.4	0.15	0.06	lasso	2	0.06	4.0e-05	-7.67	-7.1	9.6e-13	-0.02	0.24	0.65	FALSE
57	GTEx	Testis	RP5-1112D6.4	0.16	0.11	lasso	3	0.09	6.1e-05	-6.87	-7.1	1.1e-12	0.04	0.16	0.43	FALSE
16	GTEx	Brain Cortex	PPIL6	0.29	0.22	lasso	5	0.18	1.1e-05	5.62	-7.0	1.9e-12	0.17	0.50	0.05	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	AK9	0.28	0.02	enet	22	0.09	1.8e-03	-2.03	7.0	2.6e-12	-0.18	0.23	0.09	FALSE
30	GTEx	Esophagus Mucosa	KIAA1919	0.10	0.02	enet	20	0.05	4.4e-04	-7.93	-6.9	4.5e-12	0.02	0.03	0.94	FALSE
53	GTEx	Stomach	KIAA1919	0.25	0.09	enet	26	0.11	6.0e-06	-6.87	-6.8	1.2e-11	-0.02	0.05	0.93	FALSE
19	GTEx	Cells Transformed fibroblasts	FIG4	0.13	0.12	lasso	3	0.11	8.3e-09	-6.27	6.7	1.6e-11	-0.17	1.00	0.00	FALSE
10	GTEx	Artery Coronary	SMPD2	0.11	0.09	lasso	4	0.07	1.9e-03	-7.57	-6.7	1.7e-11	0.24	0.36	0.04	FALSE
40	GTEx	Nerve Tibial	SMPD2	0.12	0.08	lasso	4	0.08	3.6e-06	-7.22	-6.7	1.8e-11	0.24	0.96	0.00	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIAA1919	0.09	0.06	lasso	3	0.06	1.0e-11	-6.87	-6.7	1.9e-11	0.00	0.81	0.19	FALSE
60	METSIM	Adipose	FIG4	0.06	0.00	bslmm	484	0.01	7.1e-03	-2.68	-6.7	2.0e-11	0.08	0.16	0.02	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	SMPD2	0.15	0.17	enet	14	0.18	9.4e-18	-5.07	-6.7	2.4e-11	0.21	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPIL6	0.05	0.04	blup	53	0.02	1.8e-03	5.78	-6.7	2.5e-11	0.11	0.26	0.02	FALSE
99	The Cancer Genome Atlas	Rectum Adenocarcinoma	KIAA1919	0.32	0.16	enet	11	0.11	1.6e-03	-7.67	-6.6	4.1e-11	0.00	0.01	0.45	FALSE
27	GTEx	Colon Transverse	KIAA1919	0.13	0.03	lasso	8	0.07	4.7e-04	-6.63	-6.5	6.7e-11	0.02	0.09	0.83	FALSE
85	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SMPD2	0.05	0.07	lasso	4	0.06	9.6e-08	-7.42	-6.5	9.2e-11	0.23	1.00	0.00	FALSE
94	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SESN1	0.17	0.01	blup	45	0.02	5.5e-02	7.41	-6.4	1.2e-10	0.06	0.01	0.26	FALSE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	MICAL1	0.08	0.11	lasso	4	0.12	1.8e-13	-7.42	6.4	1.6e-10	-0.23	1.00	0.00	FALSE
61	METSIM	Adipose	KIAA1919	0.04	0.05	lasso	6	0.04	7.3e-07	-6.41	-6.4	1.7e-10	0.03	0.47	0.52	FALSE
48	GTEx	Skin Sun Exposed Lower leg	KIAA1919	0.09	0.01	enet	15	0.02	1.2e-02	-7.71	-6.3	2.8e-10	-0.03	0.05	0.81	FALSE
5	GTEx	Adipose Subcutaneous	RP5-1112D6.4	0.08	0.03	lasso	4	0.03	2.1e-03	-7.67	-6.2	7.5e-10	-0.03	0.46	0.36	FALSE
38	GTEx	Muscle Skeletal	AK9	0.08	0.02	lasso	6	0.03	4.3e-04	8.78	6.1	8.7e-10	-0.26	0.86	0.03	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	TRAF3IP2	0.07	0.01	enet	15	0.03	9.0e-05	-6.45	-6.1	1.1e-09	0.07	0.44	0.16	FALSE
75	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ARMC2	0.04	0.05	lasso	1	0.04	3.4e-04	6.05	-6.0	1.5e-09	0.08	0.03	0.88	FALSE
79	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	AKD1	0.07	0.04	blup	122	0.05	2.1e-03	-6.32	-6.0	2.4e-09	0.17	0.54	0.12	FALSE
33	GTEx	Esophagus Muscularis	KIAA1919	0.11	0.04	enet	8	0.05	7.3e-04	1.73	-6.0	2.6e-09	0.01	0.19	0.34	FALSE
34	GTEx	Heart Atrial Appendage	RP11-425D10.10	0.12	0.11	lasso	5	0.07	4.0e-04	-1.38	-6.0	2.7e-09	0.19	0.71	0.02	FALSE
32	GTEx	Esophagus Muscularis	AK9	0.41	0.22	enet	60	0.29	5.7e-18	-1.46	5.9	3.4e-09	-0.25	1.00	0.00	FALSE
50	GTEx	Spleen	KIAA1919	0.18	0.16	lasso	4	0.14	1.5e-04	-6.38	-5.8	4.8e-09	0.02	0.11	0.38	FALSE
91	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SMPD2	0.04	0.06	blup	45	0.06	8.9e-08	-5.07	-5.8	5.0e-09	0.20	1.00	0.00	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	SMPD2	0.12	0.10	lasso	5	0.09	1.3e-11	-5.10	-5.8	5.2e-09	0.20	1.00	0.00	FALSE
41	GTEx	Nerve Tibial	AK9	0.18	0.15	enet	26	0.18	1.5e-12	-1.38	5.8	6.1e-09	-0.23	1.00	0.00	FALSE
59	GTEx	Thyroid	RP11-425D10.10	0.20	0.05	enet	26	0.11	5.9e-09	6.94	5.8	9.0e-09	-0.14	1.00	0.00	FALSE
49	GTEx	Skin Sun Exposed Lower leg	RP11-425D10.10	0.19	0.23	enet	18	0.23	3.4e-19	-1.46	-5.7	1.6e-08	0.24	1.00	0.00	FALSE
98	The Cancer Genome Atlas	Rectum Adenocarcinoma	ARMC2	0.38	0.00	blup	88	0.08	7.2e-03	0.76	-5.6	2.1e-08	0.08	0.01	0.21	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	AK9	0.19	0.10	enet	25	0.13	1.7e-05	8.78	5.5	3.8e-08	-0.25	0.86	0.01	FALSE
24	GTEx	Cells Transformed fibroblasts	C6orf3	0.35	0.05	enet	41	0.13	1.2e-09	-5.89	5.4	5.9e-08	-0.03	0.76	0.06	FALSE
4	GTEx	Adipose Subcutaneous	KIAA1919	0.07	0.01	enet	16	0.01	3.6e-02	2.91	-5.4	6.4e-08	0.02	0.27	0.18	FALSE
26	GTEx	Colon Transverse	SMPD2	0.19	0.25	lasso	5	0.24	1.1e-11	-5.03	-5.4	6.5e-08	0.20	1.00	0.00	FALSE
43	GTEx	Nerve Tibial	RP5-1112D6.4	0.06	0.03	enet	6	0.00	3.2e-01	-6.87	-5.3	1.2e-07	0.02	0.17	0.27	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	ZBTB24	0.03	0.00	blup	389	0.00	7.3e-02	-2.43	5.3	1.3e-07	-0.20	0.32	0.02	FALSE
62	METSIM	Adipose	MICAL1	0.06	0.01	bslmm	392	0.03	3.9e-05	-4.79	5.2	1.7e-07	-0.16	0.95	0.00	FALSE
54	GTEx	Stomach	RP11-425D10.10	0.25	0.10	lasso	6	0.09	3.0e-05	-5.09	-5.2	1.8e-07	0.16	0.90	0.01	FALSE
64	NTR	Blood	KIAA1919	0.02	0.01	blup	390	0.01	1.2e-04	-6.56	-5.2	2.4e-07	0.07	0.04	0.95	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	PPIL6	0.10	0.09	enet	11	0.08	7.7e-08	6.94	-5.1	2.7e-07	0.07	0.99	0.00	FALSE
103	The Cancer Genome Atlas	Stomach Adenocarcinoma	MICAL1	0.09	0.01	blup	50	0.01	3.5e-02	5.98	5.1	3.1e-07	-0.12	0.03	0.04	FALSE