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chr9:114,119,984-117,058,254

Best TWAS P=4.96e-15 · Best GWAS P=2.26e-17 conditioned to 6.08e-17

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Adipose Subcutaneous	C9orf43	0.06	0.05	lasso	3	0.05	9.0e-05	-7.6	7.8	5.0e-15	-0.01	0.02	0.97	TRUE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	SUSD1	0.09	0.02	blup	122	0.03	5.7e-04	-7.5	-7.5	9.1e-14	0.08	0.12	0.04	TRUE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNX30	0.05	0.04	lasso	3	0.04	1.3e-04	-6.8	-6.9	7.0e-12	-0.01	0.00	1.00	TRUE
10	GTEx	Muscle Skeletal	ALAD	0.08	0.03	enet	18	0.06	6.2e-07	2.6	-5.3	1.2e-07	-0.09	0.76	0.01	TRUE
35	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C9orf43	0.30	0.17	lasso	4	0.16	4.9e-05	-7.6	7.7	1.2e-14	-0.01	0.00	0.99	FALSE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	C9orf43	0.11	0.06	lasso	5	0.05	1.7e-04	-6.8	7.7	1.8e-14	-0.02	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	C9orf43	0.13	0.11	blup	57	0.16	3.7e-15	-7.6	7.7	1.9e-14	0.01	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	C9orf43	0.18	0.24	enet	6	0.24	4.3e-25	-6.8	7.5	8.4e-14	-0.03	0.03	0.97	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	C9orf43	0.08	0.10	lasso	3	0.10	2.5e-20	-7.2	7.3	2.0e-13	-0.02	0.02	0.98	FALSE
9	GTEx	Esophagus Mucosa	C9orf43	0.13	0.13	lasso	4	0.12	1.4e-08	-7.1	7.3	2.5e-13	-0.04	0.09	0.91	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SUSD1	0.06	0.04	enet	7	0.06	5.9e-07	-7.4	-7.3	2.8e-13	0.38	0.18	0.16	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	SUSD1	0.07	0.00	blup	121	0.02	1.3e-02	3.1	-7.3	3.3e-13	0.46	0.04	0.15	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	C9orf43	0.12	0.16	enet	5	0.16	6.9e-18	-7.2	7.2	4.5e-13	-0.03	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Rectum Adenocarcinoma	C9orf43	0.49	0.17	enet	6	0.14	4.7e-04	-6.8	7.2	5.9e-13	-0.03	0.02	0.73	FALSE
4	GTEx	Adipose Visceral Omentum	C9orf43	0.12	0.08	lasso	10	0.06	3.0e-04	-7.2	7.2	6.7e-13	-0.03	0.08	0.90	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C9orf43	0.12	0.13	lasso	2	0.13	5.2e-14	-7.2	7.2	6.7e-13	-0.03	0.03	0.97	FALSE
33	The Cancer Genome Atlas	Soft Tissue Sarcoma	C9orf43	0.11	0.10	lasso	5	0.09	4.9e-06	-7.2	7.2	6.9e-13	-0.04	0.02	0.96	FALSE
38	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C9orf43	0.13	0.15	enet	6	0.13	2.3e-05	-6.8	7.2	8.2e-13	-0.03	0.01	0.95	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	C9orf43	0.20	0.21	lasso	2	0.18	2.4e-06	-7.1	7.2	8.9e-13	-0.04	0.10	0.89	FALSE
17	The Cancer Genome Atlas	Colon Adenocarcinoma	C9orf43	0.19	0.17	enet	9	0.16	1.2e-09	-7.2	7.1	1.5e-12	-0.03	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	C9orf43	0.07	0.05	lasso	5	0.05	5.8e-06	-7.2	7.1	1.7e-12	-0.04	0.02	0.98	FALSE
13	METSIM	Adipose	C9orf43	0.05	0.05	lasso	1	0.03	5.8e-06	-7.0	7.0	1.9e-12	-0.04	0.11	0.89	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C9orf43	0.09	0.10	lasso	2	0.09	5.9e-10	-6.8	7.0	2.0e-12	-0.03	0.03	0.97	FALSE
27	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C9orf43	0.26	0.26	lasso	4	0.23	1.0e-09	-6.8	7.0	2.4e-12	-0.03	0.03	0.97	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C9orf43	0.21	0.19	blup	58	0.19	7.5e-21	-6.8	7.0	3.0e-12	-0.02	0.03	0.97	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C9orf43	0.11	0.08	lasso	5	0.06	3.8e-05	-6.8	6.9	5.3e-12	-0.03	0.02	0.97	FALSE
14	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C9orf43	0.10	0.12	lasso	1	0.12	2.0e-10	-6.8	6.8	8.3e-12	-0.03	0.03	0.97	FALSE
16	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C9orf43	0.10	0.06	lasso	6	0.06	1.0e-03	-6.8	6.8	1.3e-11	-0.01	0.02	0.90	FALSE
26	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SUSD1	0.10	0.04	enet	9	0.08	5.5e-06	3.1	-6.8	1.4e-11	0.17	0.83	0.01	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	RGS3	0.04	0.04	lasso	2	0.03	2.5e-04	-6.4	6.6	3.9e-11	-0.01	0.18	0.47	FALSE
5	GTEx	Brain Cortex	RP11-4O1.2	0.44	0.00	enet	43	0.07	5.0e-03	3.1	-6.5	6.0e-11	0.34	0.12	0.09	FALSE
11	GTEx	Stomach	C9orf43	0.11	0.01	enet	13	0.03	1.3e-02	-7.1	6.5	6.8e-11	0.00	0.06	0.90	FALSE
8	GTEx	Cells Transformed fibroblasts	C9orf43	0.13	0.09	enet	31	0.11	1.6e-08	-7.1	6.4	2.0e-10	-0.02	0.12	0.88	FALSE
12	GTEx	Testis	C9orf43	0.52	0.59	enet	31	0.65	3.4e-37	-7.1	6.2	5.9e-10	-0.04	0.11	0.89	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C9orf43	0.13	0.08	blup	57	0.07	4.9e-05	-7.2	6.1	1.2e-09	0.00	0.03	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RGS3	0.11	0.01	blup	653	0.05	7.2e-07	-6.8	6.0	2.7e-09	-0.03	0.11	0.86	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	PTBP3	0.18	0.01	lasso	2	-0.01	6.4e-01	-5.7	5.8	9.1e-09	-0.06	0.13	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SLC46A2	0.25	0.08	lasso	8	0.14	6.0e-17	-4.9	5.5	2.9e-08	-0.02	0.03	0.97	FALSE
34	The Cancer Genome Atlas	Soft Tissue Sarcoma	HDHD3	0.11	0.00	enet	11	0.04	1.9e-03	-2.9	-5.4	6.9e-08	0.00	0.01	0.74	FALSE