Hub : Genes

PTBP3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2779	0.0826	1.3e-04	0.050	NA	0.022	NA	0.051	7.2e-03	NA	5.2e-02	NA	0.0066
2	GTEx	Artery Aorta	0.1430	0.0470	1.1e-04	0.106	NA	0.075	NA	0.043	1.8e-06	NA	6.4e-05	NA	0.0022
3	GTEx	Breast Mammary Tissue	0.0960	0.0440	6.9e-03	0.014	NA	0.010	NA	0.006	6.1e-02	NA	9.4e-02	NA	0.1400
4	GTEx	Breast Mammary Tissue (Female)	0.0698	0.0539	9.6e-02	-0.001	NA	-0.009	NA	-0.010	3.4e-01	NA	8.3e-01	NA	0.8800
5	GTEx	Cells EBV-transformed lymphocytes	0.1780	0.0790	5.8e-03	0.015	NA	-0.009	NA	-0.007	1.0e-01	NA	8.6e-01	NA	0.6400
6	GTEx	Cells Transformed fibroblasts	0.0690	0.0300	2.4e-03	0.039	NA	0.021	NA	0.029	6.2e-04	NA	1.0e-02	NA	0.0028
7	GTEx	Muscle Skeletal	0.1270	0.0417	4.5e-06	-0.003	NA	0.003	NA	0.000	8.8e-01	NA	1.6e-01	NA	0.3100

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	3.3	5.2	9.6	-2.6	-0.8	-2.1	-2.7	-1.8	-3.1	-2.1
Bipolar Disorder or Schizophrenia	3.9	9.6	16.0	-3.6	-0.4	-2.4	-3.3	-3.9	-4.0	-2.6
Depressed Affect (Nagel 2018)	0.2	0.5	2.0	-0.6	-0.4	-1.4	-0.2	-0.8	-0.1	-0.1
Depression (Nagel 2018)	0.2	0.3	1.0	-0.4	0.2	-0.7	-0.5	-0.0	-1.0	-0.2
Intelligence (Savage-Jansen 2018)	2.2	6.7	15.8	-0.9	3.5	4.0	2.6	1.1	2.8	1.4
Neuroticism (Nagel 2018)	0.7	1.5	3.6	-1.9	-0.6	-1.7	-0.6	-1.4	-0.7	-1.0
Schizophrenia (2018)	2.3	4.8	12.2	-2.4	0.2	-1.5	-2.1	-3.5	-2.6	-1.5
Schizophrenia vs Biploar Disorder	0.2	0.2	1.0	-0.2	-1.0	-0.3	-0.3	0.1	-0.4	0.6
Worry (Nagel 2018)	2.8	5.9	7.6	-2.8	-2.8	-2.7	-2.1	-1.5	-2.4	-2.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.8	1.2	0.2	0.3	1.3	-0.0	1.1	0.7
Alzheimer’s Disease (in father)	1.0	1.0	3.1	-1.3	0.3	0.9	1.8	1.1	0.0	-0.6
Alzheimer’s Disease (including proxy)	0.6	0.9	3.6	-0.0	0.7	0.8	1.9	-0.2	1.1	0.1
Crohns Disease (2017)	0.8	1.7	3.7	-1.6	-0.2	-1.0	-1.2	-1.9	-1.5	-0.9
Irritable Bowel Disease (IBD)	2.5	6.0	8.9	-2.6	-1.3	-2.1	-2.3	-3.0	-2.7	-2.9
Ulcerative Colitis (UC)	3.0	5.6	10.1	-2.0	-1.7	-2.0	-2.2	-2.5	-2.6	-3.2
Major Depression (MDD)	1.3	1.6	4.1	-0.8	-1.3	-1.2	-1.1	-0.7	-2.0	-1.4
Reaction Time	2.6	5.0	8.9	-2.2	-1.2	-2.0	-2.6	-1.0	-2.7	-3.0
Verbal and Numeric Reasoning (VNR)	0.9	2.1	5.3	-2.1	2.3	2.0	0.5	-0.8	0.2	0.2
Breast Cancer	0.6	1.4	3.2	0.9	1.1	0.4	1.4	1.8	1.3	0.9
Ovarian Cancer	0.3	0.4	1.2	-0.5	0.1	0.6	0.5	0.1	1.1	0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.9	2.7	6.1	-0.7	2.4	2.5	1.3	0.9	1.9	0.6
Bipolar Disorder (2011)	2.6	2.5	5.6	-1.1	-0.6	-1.9	-1.3	-2.4	-1.9	-1.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.3	0.1	0.6	0.1	0.9	-1.1	-0.0	-0.1
Coronary Artery Disease (CAD)	0.2	0.3	0.9	0.3	-0.1	0.5	0.6	1.0	0.3	0.6
Crohns Disease (2012)	0.3	0.5	1.2	-1.0	1.1	0.2	-0.1	-0.9	-0.4	0.1
Mean Putamen Volume	0.5	0.5	0.9	0.4	0.9	1.0	1.0	0.6	0.5	0.3
Fasting Glucose	0.1	0.2	0.8	0.4	-0.0	0.4	-0.2	0.0	-0.3	0.9
HbA1C	1.4	1.6	3.2	0.2	0.4	1.2	1.8	1.1	1.3	1.7
HDL Cholesterol	1.3	2.1	5.5	0.7	1.0	2.4	1.7	0.9	1.8	0.8
LDL Cholesterol	0.2	0.4	1.1	-0.6	0.7	1.1	-0.3	0.9	0.0	-0.1
Lupus	1.5	2.3	5.4	0.1	-2.3	-2.3	-1.2	-0.6	-1.3	-1.3
Neuroticism (2016)	1.1	1.6	3.1	-0.7	-0.9	-1.8	-1.8	-1.6	-0.9	0.7
Primary Biliary Cirrhosis	0.4	0.6	2.0	-0.8	-0.1	0.3	-0.2	-1.4	-0.4	-1.1
Rheumatoid Arthritis	0.4	0.5	3.0	0.3	-0.1	0.5	-0.2	-1.7	-0.3	-0.1
Schizophrenia (2014)	3.3	7.3	16.2	-2.8	-0.8	-2.4	-2.6	-4.0	-3.2	-1.8
Triglycerides	0.5	0.8	1.9	-1.0	-0.9	-0.3	-0.6	-0.2	-1.4	-1.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.0	0.1	0.3	0.4	0.8	0.0	0.6	1.0
Ulcerative Colitis	2.0	3.0	8.6	-1.8	-0.7	-0.7	-1.1	-2.0	-1.7	-2.9
Blood Eosinophil Count	1.2	9.0	20.5	-1.5	0.1	-3.5	-3.1	-4.5	-3.1	-3.0
Blood Platelet Count	0.1	0.6	2.0	-0.1	1.4	-0.2	0.4	-0.7	0.5	1.2
Blood Red Count	1.3	12.5	33.1	3.1	-0.5	2.5	1.7	5.8	4.5	4.0
Blood White Count	1.1	8.3	18.0	-0.4	-0.6	-3.6	-4.2	-3.5	-3.4	-1.7
Heel T-Score	0.1	0.7	2.4	0.0	-1.4	-0.0	0.6	1.6	0.5	0.0
BMI	0.2	1.4	6.1	-0.2	1.7	-0.5	0.7	-2.5	-0.1	0.7
Height	0.8	14.6	36.6	-0.9	5.7	6.0	2.8	0.1	3.9	3.0
Waist Hip Ratio (WHR)	0.8	3.4	8.3	-1.2	-1.5	-2.1	-0.9	-0.7	-2.9	-2.5
Systolic Blood Pressure	0.2	0.8	3.3	-0.4	-1.8	-1.3	-0.5	0.4	-0.3	-0.5
Smoking Status	0.7	1.6	4.8	1.1	-0.2	-1.2	-1.5	-0.9	-0.6	2.2
Allergy or Eczema	0.2	0.5	1.8	-1.3	-0.1	-0.1	1.0	-0.6	-0.1	0.1
Cardiovascular Disease	0.7	2.3	6.0	0.7	-1.5	-2.5	-2.0	-1.5	-0.9	-0.6
Hypothyroidism (self reported)	0.7	1.7	3.5	-1.1	-0.7	-0.9	-1.8	-1.9	-0.8	-1.3
Respiratory disease	0.4	0.9	4.3	0.1	0.6	0.4	2.1	0.6	1.1	0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.3	-0.1	1.2	1.2	1.5	-0.1	0.6	-0.1
Lung FEV1/FVC ratio	1.7	8.8	17.2	-1.3	-1.9	-4.1	-1.9	-4.2	-3.4	-2.6
Lung FVC	0.1	0.4	1.2	-0.8	1.1	0.6	0.2	0.2	0.5	0.6
Neuroticism	1.3	3.2	6.6	-2.6	-1.1	-2.2	-0.9	-2.2	-1.3	-1.5
Chronotype (morning person)	5.9	13.7	21.4	3.9	1.4	3.5	3.4	4.4	4.6	3.8
Hair Pigment	0.1	3.3	10.4	1.1	-3.2	-2.9	-0.3	-1.4	-0.6	-0.8
Tanning	0.2	2.5	8.0	-0.5	2.8	2.5	1.0	-0.1	0.7	1.3
Hand grip strength (left)	1.8	4.7	10.0	0.1	3.2	3.1	1.0	0.4	2.0	2.8
Number of treatments/medications taken	0.6	1.0	1.8	1.3	-0.2	0.1	0.6	1.3	1.2	1.3
Average weekly spirits intake	0.2	0.3	1.2	-0.4	-0.4	0.4	0.0	1.1	-0.5	-0.3
Sensitivity / hurt feelings	0.7	1.1	4.5	-0.7	1.3	0.5	0.4	-2.1	0.5	0.7
Frequency of depressed mood in last 2 weeks	1.5	2.1	5.3	-1.5	-1.2	-1.5	-1.8	-0.3	-2.3	-0.3
Hearing difficulty/problems: Yes	0.9	1.4	3.2	0.1	0.8	1.3	1.0	1.1	1.8	1.3
Relative age of first facial hair	0.9	1.9	6.2	2.5	-1.4	0.4	0.8	1.3	1.4	0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.0	0.1	0.7	0.3	0.4	-1.4	0.2	-0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.0	0.4	-0.8	-1.0	0.6	0.0	-0.2	0.1
Ever had hysterectomy (womb removed)	1.0	1.1	3.8	0.9	-1.9	-0.7	-0.1	1.5	0.8	0.2
Systolic blood pressure, automated reading	0.3	1.0	3.6	0.9	-0.8	-0.0	0.8	1.9	0.9	0.5
Eye problems/disorders: Diabetes related eye disease	3.7	4.0	6.2	-1.8	-1.4	-2.5	-1.7	-2.4	-2.1	-1.9
Angina	0.6	0.8	2.3	0.7	-0.6	-1.4	-0.3	1.5	-0.1	-0.3
Medication for hormone replacement therapy	0.6	0.7	2.0	1.4	-0.1	-0.3	0.4	1.0	0.7	1.0
Vitamin and mineral supplements	1.4	1.9	4.8	-1.5	0.6	-1.0	-2.2	-1.5	-1.6	-0.1
Supplements: Zinc	0.7	0.8	3.7	-1.9	0.9	0.4	0.1	-0.3	0.1	-0.8
Medication: Co-codamol	0.5	0.5	1.0	0.5	-0.0	1.0	0.6	0.8	0.8	-0.9
Medication: Metformin	1.0	1.4	3.7	-1.9	0.5	0.9	1.6	-1.5	0.1	-0.5
Diabetes (father)	0.4	0.4	1.1	-1.1	0.9	0.8	-0.5	-0.4	-0.1	-0.3
Diabetes (mother)	0.3	0.4	1.0	-0.2	-0.4	0.1	1.0	0.3	0.9	0.8
Severe depression (siblings)	1.1	1.2	3.2	-0.5	-0.2	-0.9	-1.8	-0.6	-1.4	-1.4
Pack years adult smoking proportion	0.3	0.5	2.3	1.5	-0.6	-0.1	-0.1	-0.0	0.3	0.6
Impedance of leg (right)	0.3	1.6	7.0	0.1	-2.6	-0.5	-0.1	1.8	-0.6	-0.5
Leg fat-free mass (left)	0.9	4.7	12.4	0.3	3.5	2.1	0.6	-3.1	1.3	2.0
Trunk fat percentage	0.2	0.9	5.7	0.3	0.7	-0.5	-0.0	-2.4	-0.2	-0.0
Hand grip strength (right)	2.7	7.4	12.2	1.1	3.1	3.5	1.9	1.5	3.3	3.5
Townsend deprivation index at recruitment	0.7	1.0	3.3	0.6	-1.3	-0.1	0.1	1.8	0.8	1.0
Current tobacco smoking	0.8	1.3	2.4	1.5	-1.1	-1.5	-1.2	-0.7	-1.1	0.5
Average weekly fortified wine intake	1.4	1.7	2.7	-0.8	-0.3	-1.3	-1.5	-1.3	-1.6	-1.7
Maternal smoking around birth	0.5	0.7	1.4	0.0	-0.8	-1.2	-1.1	-0.9	-0.7	-0.2
Fed-up feelings	1.1	1.9	3.7	0.3	1.5	1.4	1.3	1.1	1.9	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	0.6	0.5	-0.0	-0.5	0.8	0.2	1.1
Relative age voice broke	0.6	1.0	5.1	2.3	0.0	0.0	0.6	0.5	0.7	0.8
Taking other prescription medications	0.2	0.3	1.0	-0.0	-0.9	-0.1	1.0	-0.2	0.6	0.1
Age when periods started (menarche)	1.5	3.6	10.6	1.0	-0.1	2.4	1.9	3.3	2.0	0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.5	-0.7	-0.8	0.2	0.6	-0.7	-0.1	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.8	0.9	-1.2	-1.3	-0.9	-0.1	0.0	0.9
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	5.5	-2.3	-0.5	-1.1	0.9	-2.1	-1.2	-1.5
Qualifications: CSEs or equivalent	0.4	0.5	2.2	0.8	0.2	-1.5	0.1	-0.7	-0.2	0.4
Serious illness, injury or assault to yourself	0.4	0.4	1.3	0.6	-0.0	-0.3	1.1	-0.2	0.8	0.7
High blood pressure	0.5	1.3	3.7	0.9	-1.9	-1.7	-1.3	-0.0	-0.5	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.1	-1.4	0.2	0.5	0.8	-1.2	0.1	0.1
Multivitamins +/- minerals	0.8	1.0	2.2	-0.3	-1.0	1.5	1.2	1.5	0.6	0.1
Stomach or abdominal pain in last month	3.3	4.1	8.6	-0.9	-2.5	-2.4	-0.9	-0.6	-2.9	-2.5
Supplements: Glucosamine	0.8	1.1	2.8	-0.0	1.5	1.0	1.7	0.4	1.1	0.7
Diverticular disease/diverticulitis (self-reported)	1.7	2.1	3.1	-1.8	-1.7	-1.7	-1.3	-0.7	-1.4	-1.1
Medication: Atenolol	0.7	0.8	2.2	-0.2	-1.5	0.2	-1.2	0.9	-0.5	-1.0
Medication: Levothyroxine sodium	1.1	1.8	2.7	-1.2	-1.1	-1.6	-1.6	-1.3	-0.9	-1.5
Sitting height	0.4	3.0	9.2	-0.5	3.0	2.1	-0.1	-1.2	1.2	2.1
Chronic bronchitis/emphysema (father)	0.9	1.1	6.6	0.4	-2.6	-0.6	0.2	0.6	-0.3	-0.2
High blood pressure (mother)	0.1	0.1	0.2	0.1	-0.5	0.5	-0.3	-0.2	-0.2	-0.5
Body mass index (BMI)	0.4	1.5	4.6	0.5	2.0	-0.0	0.6	-2.1	0.4	1.1
Impedance of leg (left)	0.4	1.9	7.8	0.0	-2.8	-0.6	-0.6	2.1	-0.5	-0.4
Leg predicted mass (left)	0.9	4.7	12.2	0.3	3.5	2.1	0.6	-3.1	1.4	2.1
Trunk fat mass	0.3	1.4	5.7	0.6	1.7	0.3	0.3	-2.4	0.5	0.9
Waist circumference	0.3	1.1	4.7	-0.2	1.6	-0.1	0.0	-2.2	-0.2	0.2
Number of incorrect matches in round	1.9	3.2	7.7	-2.0	-1.0	-1.7	0.0	-1.2	-2.3	-2.8
Past tobacco smoking	0.4	0.8	2.8	-0.1	0.5	0.6	1.0	-1.0	-0.2	-1.7
Alcohol usually taken with meals	1.1	1.8	10.3	-0.0	0.7	0.8	0.5	3.2	0.6	0.8
Nervous feelings	2.5	4.6	8.4	-2.9	-2.5	-2.5	-1.2	-1.2	-2.4	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.5	-1.2	-1.4	-1.4	-0.9	-0.5	-1.6	-1.1
Hearing difficulty/problems with background noise	0.3	0.4	1.0	-1.0	0.9	0.7	-0.1	-0.4	0.6	0.3
Hair/balding pattern: Pattern 2	0.5	0.6	2.0	-0.1	0.0	1.3	1.4	0.0	0.7	-0.3
Had menopause	0.7	0.8	2.5	-1.1	-0.6	-1.6	-0.2	-0.6	-0.8	-0.9
Had other major operations	0.4	0.5	1.4	-0.1	0.3	0.9	0.5	1.2	0.6	0.7
Forced vital capacity (FVC)	0.6	2.2	6.1	-1.0	2.0	2.5	0.2	-1.2	1.2	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.3	0.2	-1.0	-1.1	-0.6	-0.2	-0.1	0.1
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	5.4	-1.6	-1.9	-2.1	-1.2	-1.6	-2.3	-1.9
Qualifications: None of the above	1.1	2.3	6.4	1.0	-2.5	-1.6	-1.7	1.4	-0.9	-0.5
Financial difficulties in last 2 years	0.5	0.7	1.6	-1.3	-0.4	-0.5	-0.8	-0.8	-1.2	0.2
Mouth/teeth dental problems	0.6	0.9	3.1	-0.8	-0.3	1.5	0.3	1.8	0.2	0.6
Heart attack	1.5	2.0	4.2	2.1	0.1	1.2	0.7	2.0	1.9	0.2
Allergy	0.4	0.9	2.2	1.1	0.1	-0.7	-1.5	1.1	-0.7	-0.8
Pain all over the body in last month	0.3	0.3	1.2	0.2	-0.2	0.4	1.1	0.4	0.9	-0.1
Diabetes (self-reported)	1.4	2.1	7.2	-0.0	1.1	1.5	2.7	0.9	1.7	0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.0	-1.0	0.4	0.3	0.6	-1.4	-0.1	0.2
Medication: Ramipril	1.0	1.3	4.6	1.0	-0.6	-1.7	-2.1	0.4	-0.7	-0.1
Medication: Simvastatin	1.3	1.9	4.4	2.1	0.9	0.4	0.6	1.5	2.0	1.0
Fluid intelligence score	0.9	1.9	5.9	-0.7	2.4	2.3	0.4	-0.6	0.6	0.8
Illnesses of siblings	0.8	1.1	3.4	-1.1	0.7	1.3	1.8	0.6	0.7	-0.3
Neuroticism score	1.9	3.9	7.3	-2.7	-1.4	-2.4	-1.3	-2.2	-2.0	-1.5
Weight	0.8	3.9	10.6	0.6	3.3	1.6	0.7	-2.7	1.4	2.0
Impedance of arm (right)	1.1	5.3	8.5	-1.9	-2.5	-2.0	-2.0	-2.0	-2.7	-2.9
Arm fat percentage (right)	0.5	1.8	9.1	0.2	0.8	-1.4	-0.5	-3.0	-0.8	-0.1
Trunk fat-free mass	1.3	7.6	18.0	1.0	4.2	3.4	1.4	-0.7	2.8	3.5
Hip circumference	0.4	1.8	6.5	0.1	1.8	0.7	-0.2	-2.6	0.5	1.3
Time employed in main current job	0.5	0.5	1.3	0.9	-0.1	0.5	0.3	1.1	1.1	0.4
Alcohol intake versus 10 years previously	1.0	1.5	3.6	0.8	-0.3	0.7	1.0	1.9	1.3	1.6
Father’s age at death	1.0	1.3	4.9	-2.2	1.1	0.6	0.3	-1.0	-0.4	-1.2
Worrier / anxious feelings	0.7	1.3	2.8	-0.9	-1.2	-0.7	-1.7	-1.4	-1.3	-0.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	4.2	1.3	-1.6	-2.0	-1.2	-1.4	-0.4	0.3
Falls in the last year	0.2	0.3	1.1	-0.0	0.0	0.4	0.9	-1.1	-0.0	-0.5
Hair/balding pattern: Pattern 3	3.0	4.5	9.4	2.4	3.1	2.0	1.1	1.1	2.3	2.1
Number of live births	0.4	0.6	2.2	-1.5	-0.6	-0.0	-0.5	-0.3	-0.4	-1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	4.8	-1.2	1.5	1.5	0.0	-2.2	0.3	0.1
Pulse rate	0.3	0.5	1.5	0.1	-1.0	0.3	0.6	-1.2	-0.0	-0.8
Happiness	1.2	1.4	2.6	-1.6	-1.1	-1.3	-0.5	-1.1	-1.6	-0.7
Noisy workplace	0.7	0.8	2.6	0.5	-0.7	-1.2	-0.4	-1.6	-1.0	-0.3
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.8	-0.5	0.9	1.4	2.2	-0.3	0.9	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	0.6	-0.1	-0.4	-0.7	-0.2	-0.6	-0.9
Mouth/teeth dental problems: Dentures	0.5	0.8	2.4	-0.2	-0.9	-1.5	-0.6	-0.3	-0.5	-1.4
Asthma	0.2	0.5	0.9	0.6	-0.8	-0.6	0.8	-0.2	0.6	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.4	0.9	0.3	-0.2	1.1	0.4	1.2	0.9
Medication: Cholesterol lowering	0.8	1.2	3.8	2.0	0.2	-0.6	0.7	0.9	1.6	0.8
Depression (self-reported)	1.1	1.3	3.0	-1.7	-0.9	-0.0	-1.4	-0.9	-1.2	-0.9
Medication: Lansoprazole	0.4	0.4	2.5	-0.1	-1.6	-0.5	0.0	0.2	0.2	-0.3
Prospective memory result	0.2	0.2	1.5	1.2	-0.1	0.2	-0.1	0.0	0.1	0.1
Lung cancer (father)	0.7	0.8	4.1	2.0	0.1	-0.8	-0.6	-0.6	0.2	0.2
Illnesses of mother	0.8	1.0	3.7	-0.6	-0.5	-0.7	-1.9	-1.0	-1.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	3.5	-0.7	0.6	0.9	-0.3	-1.9	0.4	0.4
Pulse wave Arterial Stiffness index	1.3	1.5	3.3	0.3	1.8	1.4	1.6	0.6	1.3	0.9
Impedance of arm (left)	0.8	3.6	6.1	-1.5	-2.0	-1.3	-1.8	-1.8	-2.2	-2.5
Arm fat mass (right)	0.4	1.8	7.0	0.6	1.9	-0.1	0.2	-2.6	0.3	1.1
Trunk predicted mass	1.3	7.7	18.4	1.2	4.3	3.4	1.4	-0.7	2.9	3.5
Standing height	0.5	5.4	12.9	0.0	3.4	3.6	0.8	-1.6	2.3	2.3
Length of working week for main job	0.3	0.3	0.8	0.9	-0.5	-0.2	0.0	-0.9	-0.4	0.6
Exposure to tobacco smoke at home	2.5	2.8	5.6	1.0	2.4	1.8	1.8	0.8	1.6	1.8
Breastfed as a baby	0.6	0.7	2.9	0.4	-0.9	-1.7	-0.9	0.2	-0.6	0.3
Tense / ‘highly strung’	4.2	7.0	12.3	-2.7	-2.8	-3.5	-2.9	-0.5	-2.5	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	5.1	7.8	14.5	-3.4	-1.8	-2.6	-2.7	-1.7	-3.8	-3.0
Hair/balding pattern: Pattern 4	0.3	0.8	2.4	0.6	0.9	0.1	0.6	1.1	0.7	1.6
Birth weight of first child	1.7	3.0	10.6	-0.1	3.3	1.9	1.5	1.2	1.6	0.8
Peak expiratory flow (PEF)	0.8	1.8	4.9	0.2	1.4	2.2	1.5	-0.4	1.5	1.0
Pulse wave reflection index	1.8	2.2	5.6	0.8	2.4	0.4	1.6	1.2	1.5	1.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.5	-0.9	-0.3	-1.0	0.0	-1.1	-1.2	-1.0
Loud music exposure frequency	1.0	1.1	2.9	-0.8	-1.4	-0.6	-1.7	0.2	-1.4	-0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.9	-0.4	1.1	1.9	2.0	-1.1	1.0	0.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.5	-0.8	1.8	0.5	-0.1	-1.9	-0.6	0.2
Blood clot in the leg (DVT)	0.6	0.8	2.2	-1.5	0.3	0.3	1.0	-1.3	0.1	-0.7
Medication: Paracetamol	0.3	0.5	2.0	0.4	0.6	0.3	0.7	1.4	0.5	0.4
Headache pain in last month	0.3	0.5	1.7	-0.8	-0.3	0.8	1.3	0.6	-0.0	-0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.9	-1.7	0.9	1.4	-0.0	-0.5	-1.0	-0.6
Glaucoma (self-reported)	0.5	0.6	2.3	-1.5	0.1	0.3	-0.6	-0.9	-0.8	-0.2
Gout (self-reported)	0.9	1.2	4.2	-1.0	-0.4	-0.9	-0.3	-1.0	-1.2	-2.1
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	5.5	-1.6	-1.3	-2.1	-2.3	-2.0	-1.5	-1.6
Medication: Amlodipine	2.5	3.5	6.8	-0.7	-2.3	-2.6	-1.9	-0.7	-2.0	-1.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	1.2	0.5	0.8	0.3	0.8	-0.1	0.3
Birth weight	0.9	2.0	4.7	0.7	2.2	1.9	1.4	0.3	1.5	1.0
Chronic bronchitis/emphysema (mother)	0.5	0.5	0.8	0.8	-0.5	-0.6	-0.8	0.9	-0.7	-0.8
High blood pressure (siblings)	1.0	1.5	6.9	2.6	-0.9	-0.9	-0.9	-0.3	0.4	0.8
Forced vital capacity (FVC), Best measure	0.4	1.6	4.1	-0.5	1.4	2.0	-0.2	-1.1	1.3	1.5
Body fat percentage	0.2	0.7	4.0	0.5	0.6	-0.6	0.1	-2.0	-0.0	0.3
Leg fat percentage (right)	0.1	0.4	1.0	0.8	0.1	-0.7	0.2	-1.0	0.2	0.9
Arm fat-free mass (right)	1.5	7.9	14.8	1.4	3.8	3.3	1.7	-0.5	3.2	3.8
Exposure to tobacco smoke outside home	0.6	0.9	3.2	-0.2	1.8	-0.2	-0.4	-0.9	0.1	1.4
Comparative body size at age 10	0.9	2.4	9.5	-1.6	2.0	0.0	0.3	-3.1	-0.8	-0.2
Number of full brothers	1.1	1.4	3.3	-1.0	-0.6	-1.3	-1.8	-0.6	-1.3	-1.2
Worry too long after embarrassment	0.7	1.2	3.5	-1.9	-0.1	0.1	-1.6	-1.3	-0.8	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	3.7	4.9	10.2	-2.9	-1.7	-1.9	-1.2	-1.9	-3.2	-2.0
Wheeze or whistling in the chest in last year	0.3	0.5	1.0	1.0	-0.7	0.3	0.6	-0.6	0.6	0.9
Number of children fathered	0.7	0.8	4.3	0.5	0.5	-0.1	-0.3	-2.1	-0.1	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	4.3	-2.1	1.9	1.3	-0.0	-0.2	-0.5	0.6
Age at first live birth	1.4	2.5	3.8	0.7	1.4	1.7	1.5	1.5	1.9	1.9
Pulse wave peak to peak time	0.9	1.1	2.1	-0.5	-1.4	-0.9	-1.4	-0.8	-1.1	-0.7
Health satisfaction	1.9	2.5	7.8	-0.1	-0.8	-1.9	-1.3	-2.8	-2.0	0.1
Shortness of breath walking on level ground	0.8	0.9	1.7	1.2	-1.2	-1.3	-1.0	-0.4	0.1	0.9
Qualifications: College or University degree	0.5	1.7	5.0	-0.3	2.2	1.7	1.6	0.6	1.0	0.1
Eye problems/disorders: None of the above	1.6	1.9	4.6	2.2	0.0	0.9	1.1	2.1	1.4	0.1
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.5	1.8	0.3	0.9	1.9	1.3	1.1	1.1
Emphysema/chronic bronchitis	0.8	0.9	3.6	0.0	-1.1	-1.9	-0.1	-0.8	-0.6	-0.4
Medication for pain relief, constipation, heartburn	0.8	1.4	3.0	-1.2	-0.6	-0.1	-1.2	-1.7	-1.4	-1.1
Neck or shoulder pain in last month	0.7	0.9	2.6	-1.3	-0.6	-0.6	0.9	-0.1	-0.7	-1.6
Medication: Blood pressure	0.6	1.1	3.0	1.3	-1.2	-1.7	-1.0	-0.2	0.0	0.7
Angina (self-reported)	0.6	0.7	2.3	1.0	-0.6	-1.2	-0.2	1.5	0.1	-0.2
Migraine (self-reported)	1.8	2.2	6.5	1.4	0.2	0.6	0.2	2.3	1.1	2.5
Medication: Ibuprofen	0.2	0.2	0.6	0.1	0.0	-0.8	0.5	-0.6	0.1	0.2
Medication: Allopurinol	0.9	1.2	3.0	-1.3	-0.0	-0.8	0.1	-1.7	-0.5	-1.7
Medication: Omeprazole	0.4	0.5	1.0	0.8	0.7	-0.2	0.9	0.5	0.6	1.0
Medication: Seretide 50 evohaler	0.3	0.3	0.6	0.3	-0.6	0.6	0.2	0.5	0.6	0.8
Mean time to correctly identify matches	2.8	5.4	8.0	-2.4	-1.4	-2.6	-2.8	-0.6	-2.6	-2.7
Heart disease (mother)	1.7	2.0	5.3	-2.3	-0.2	-1.6	0.2	-0.6	-1.7	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	8.5	0.0	0.7	2.9	1.3	1.8	0.9	0.7
Whole body fat mass	0.4	1.6	4.8	0.9	1.7	0.3	0.6	-2.2	0.8	1.4
Leg fat mass (right)	0.3	1.3	4.6	0.7	1.3	0.0	0.4	-2.1	0.5	1.4
Arm predicted mass (right)	1.7	8.5	16.5	1.4	4.1	3.6	1.9	-0.5	3.2	3.7
Pulse rate, automated reading	0.7	2.4	3.8	1.9	0.7	1.5	1.7	1.4	1.8	1.4
Alcohol intake frequency.	1.2	2.8	9.1	0.9	-2.8	-3.0	-0.0	0.2	-1.0	-0.8
Comparative height size at age 10	0.6	3.3	8.2	-1.7	2.9	2.5	-0.2	-2.2	0.7	0.6
Number of full sisters	1.9	2.3	4.4	-1.1	-0.8	-2.1	-1.2	-1.6	-1.8	-1.5
Suffer from ‘nerves’	2.1	3.4	5.9	-1.9	-1.7	-2.4	-1.6	-1.6	-1.9	-1.7
Overall health rating	0.5	1.0	2.8	1.2	-0.3	-1.7	-0.9	-0.7	-0.1	1.2
Chest pain or discomfort	0.5	0.7	3.4	-0.6	0.5	-0.2	-0.5	-1.9	-0.5	-0.1
Had major operations	0.5	0.6	3.0	-0.1	0.9	-0.0	1.7	0.1	0.3	-0.4
Age at last live birth	0.6	0.9	2.6	-1.1	0.2	1.1	1.0	1.6	0.4	0.2
Family relationship satisfaction	3.5	4.3	6.7	-2.5	-0.9	-2.2	-2.4	-1.9	-2.6	-1.5
Leg pain on walking	0.4	0.5	0.9	0.7	0.9	-0.7	0.9	-0.6	0.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	5.0	-0.1	0.2	-0.1	0.2	-2.2	-0.4	-0.1
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.8	-1.3	0.8	1.0	-0.6	-1.7	-0.0	1.3
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	5.2	-0.2	-1.5	-2.0	-2.3	-0.8	-2.2	-1.1
Medication: Aspirin	0.9	1.1	2.9	1.7	-0.4	-1.2	-1.0	0.9	0.3	1.2
Supplements: Vitamin C	0.7	0.8	2.1	1.0	0.8	-0.2	1.3	0.6	1.4	-0.1
Knee pain experienced in last month	0.2	0.3	1.0	-1.0	-0.4	-0.4	-0.0	-0.3	-0.7	-0.6
Hypertension (Self-reported)	0.7	1.8	4.1	0.9	-1.9	-2.0	-1.8	-0.5	-0.8	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.4	1.1	-1.8	-0.6	-0.6	1.4	-0.0	-0.4
Illnesses of father: Heart disease	1.9	2.7	4.2	-0.5	2.1	1.8	1.5	1.8	1.9	1.5
Illnesses of siblings: Diabetes	0.4	0.5	1.9	1.0	0.4	-0.0	-0.4	-1.4	-0.1	0.4
Smoking status: Previous	0.5	0.7	2.1	-0.2	-0.3	-0.3	-1.2	1.2	0.4	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.3	0.2	0.7	0.9	-0.4	-0.3	1.1	0.7
Whole body fat-free mass	1.1	6.5	16.6	0.8	4.1	3.0	1.1	-1.7	2.4	3.1
Leg fat-free mass (right)	0.8	4.4	12.3	0.2	3.5	2.1	0.3	-2.9	1.4	2.0
Arm fat percentage (left)	0.4	1.5	8.1	0.5	0.9	-0.9	-0.2	-2.9	-0.5	0.2
Average weekly red wine intake	0.2	0.3	1.3	-0.2	0.1	-0.4	-1.2	0.4	-0.5	0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	-0.5	-0.2	-0.1	-0.6	-0.5	-0.6	-0.3
Mood swings	1.1	1.9	4.8	-0.7	-1.8	-2.2	-1.1	-0.8	-1.4	-1.0
Loneliness, isolation	0.3	0.4	1.4	-0.8	-0.2	-0.6	0.4	-1.2	-0.2	0.5
Long-standing illness, disability or infirmity	0.6	0.9	2.2	-0.2	1.4	0.3	1.5	0.4	1.3	0.6
Ever had bowel cancer screening	0.2	0.2	0.5	-0.7	-0.2	-0.4	-0.0	-0.3	-0.7	0.4
Diabetes diagnosed by doctor	0.8	1.3	4.9	-0.9	0.8	1.1	2.2	0.0	1.0	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	3.0	-0.6	0.7	-1.0	-0.2	-1.7	-0.4	0.1
Friendships satisfaction	1.0	1.2	4.3	-1.6	1.0	0.2	-0.5	-2.1	-0.6	0.4
Qualifications: nursing, teaching	1.9	3.0	9.2	-3.0	1.9	2.0	1.2	-0.9	-0.0	-1.2
Commuting to job workplace: Walk	0.8	0.8	3.3	-0.6	0.5	-0.0	-0.4	-0.7	-1.1	-1.8
Eye problems/disorders: Cataract	0.5	0.5	2.0	-1.4	0.0	-0.8	-0.8	-0.2	-0.3	0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.1	0.6	0.7	0.3	1.0	-1.1	0.9	0.4
Medication for cholesterol	0.4	0.7	1.6	-1.2	0.2	-0.5	0.3	-0.9	-1.1	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.8	3.4	-1.7	-0.6	-1.4	-1.4	-1.1	-1.9	-1.1
Back pain experienced in last month	2.5	3.7	6.7	0.9	1.7	1.4	2.6	1.4	2.6	2.2
Mineral and other dietary supplements	0.5	0.7	1.3	0.9	0.3	0.6	-1.0	1.1	0.8	0.9
Breast cancer (self-reported)	0.3	0.4	0.7	0.8	-0.3	0.4	-0.8	0.6	0.1	0.7
Asthma (self-reported)	0.2	0.5	1.1	0.5	-0.7	-0.6	0.8	0.0	0.7	1.1
Osteoporosis (self-reported)	0.7	0.9	3.3	-0.7	-1.2	-0.8	-0.2	-0.7	-0.3	-1.8
Osteoarthritis (self-reported)	0.9	1.2	2.4	1.4	-0.2	-0.1	1.5	0.7	1.2	1.4
Medication: Aspirin	0.8	1.0	2.6	1.6	-0.4	-1.0	-1.0	1.1	0.1	1.0
Medication: Gliclazide	1.5	1.7	4.8	-0.3	1.6	1.9	2.2	-0.2	0.5	0.6
Illnesses of father: None of the above (group 1)	0.2	0.3	1.6	1.3	-0.4	-0.1	0.3	0.1	0.2	-0.0
Smoking status: Current	0.9	1.4	4.0	2.0	-1.1	-1.6	-0.8	-0.3	-0.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.5	-1.6	-0.9	-0.7	-1.1	-1.4	-1.3	-1.3
Whole body water mass	1.2	6.7	16.9	0.9	4.1	3.1	1.2	-1.5	2.5	3.2
Leg predicted mass (right)	0.8	4.5	12.3	0.1	3.5	2.1	0.3	-2.9	1.3	2.0
Arm fat mass (left)	0.5	1.9	7.2	0.7	1.9	0.3	0.4	-2.7	0.5	1.2
Number of self-reported non-cancer illnesses	0.4	0.6	2.2	0.3	-0.1	0.2	1.2	0.1	1.5	0.8
Average weekly champagne plus white wine intake	0.8	1.0	3.5	-0.6	0.8	1.9	1.3	0.8	0.4	-0.4
Miserableness	1.2	2.1	7.1	-0.6	-0.9	-2.7	-1.4	-1.0	-1.4	-1.2
Guilty feelings	1.0	1.5	5.7	-2.4	-0.3	-1.1	-0.8	-0.6	-1.2	-0.8
Wears glasses or contact lenses	0.3	0.3	1.4	-0.5	0.1	0.1	0.4	1.2	0.6	0.0
Ever taken oral contraceptive pill	0.2	0.2	1.4	-0.0	0.5	-0.0	0.0	1.2	-0.2	-0.2
Hearing aid user	0.9	1.0	2.6	0.5	1.4	0.6	1.2	-0.1	0.9	1.6
Mother’s age at death	1.4	1.7	2.7	0.3	1.6	1.5	1.6	-0.1	1.6	1.3
Financial situation satisfaction	2.8	3.5	8.1	-1.1	-1.6	-2.9	-1.7	-1.7	-2.5	-1.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.0	0.3	-0.4	0.9	0.6	1.4	0.7	0.4
Commuting to job workplace: Public transport	0.5	0.5	2.6	1.6	0.3	-0.1	-0.3	0.6	0.7	0.4
Eye problems/disorders: Glaucoma	0.9	1.1	2.5	-1.6	0.2	0.6	-1.4	-1.2	-1.1	-0.1
Medication: Blood pressure	0.3	0.5	1.2	1.1	-0.2	0.1	-0.7	1.0	0.8	0.3
Pain type(s) experienced in last month: Hip pain	0.8	1.1	2.6	-1.6	0.8	0.8	1.3	0.5	1.2	0.6
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.4	-1.0	-1.6	-1.5	-0.1	-0.7	-1.3	-0.5
High cholesterol (Self-reported)	0.6	1.1	3.1	1.6	0.5	0.5	0.4	0.6	1.8	1.0
Medication: Bendroflumethiazide	0.6	0.8	2.1	1.5	-0.5	-0.4	0.3	1.2	1.0	0.9
Medication: Paracetamol	0.4	0.6	0.9	0.7	0.9	1.0	0.9	0.7	0.8	0.2
Medication: Lisinopril	1.1	1.4	2.9	-0.8	-1.5	-1.1	-0.6	-1.4	-0.6	-1.7
Medication: Atorvastatin	1.5	1.9	4.6	-0.9	-0.1	-0.8	-2.1	-1.5	-1.8	-1.2
Illnesses of father: High blood pressure	2.5	3.1	6.9	-1.0	-0.2	-2.4	-2.6	-1.7	-2.2	-0.1
Alcohol drinker status: Never	0.9	1.0	2.6	-0.1	-1.4	-1.6	-0.1	0.0	-1.3	-1.1
Ever smoked	0.1	0.3	0.7	-0.2	-0.5	-0.3	-0.7	0.1	-0.4	0.8
Basal metabolic rate	1.1	5.9	15.3	0.8	3.9	2.7	1.0	-1.9	2.2	2.9
Leg fat percentage (left)	0.1	0.4	1.1	0.8	0.2	-0.7	0.1	-0.8	0.3	1.0
Arm fat-free mass (left)	1.5	7.5	16.6	1.3	4.1	3.1	1.6	-0.7	3.0	3.6
Number of operations (self-reported)	0.1	0.2	0.7	-0.3	0.3	-0.1	0.6	0.9	-0.3	-0.3
Average weekly beer plus cider intake	0.8	1.2	5.0	1.3	-0.5	-1.0	-0.2	-2.2	-0.6	0.4
Irritability	0.9	1.6	3.8	-1.5	-0.2	-1.2	-0.3	-1.8	-0.6	-1.9
Risk taking	0.8	1.1	2.8	1.0	-1.7	-1.2	0.0	1.5	-0.4	-0.1
Ever had prostate specific antigen (PSA) test	1.8	2.1	3.7	1.3	1.0	1.0	1.8	1.6	1.9	1.2
Fractured/broken bones in last 5 years	1.4	1.8	3.6	-0.9	-1.8	-1.2	-0.8	-1.9	-1.7	-0.6
Age started oral contraceptive pill	0.1	0.2	0.4	-0.1	0.6	0.2	-0.5	-0.4	0.5	-0.3
Diastolic blood pressure, automated reading	0.2	0.6	1.5	0.8	0.1	0.2	0.3	1.0	1.2	0.8
Ever depressed for a whole week	2.0	2.4	4.1	-1.7	-1.5	-2.0	-1.1	-0.8	-1.9	-1.5
Unable to work because of sickness or disability	0.4	0.6	1.4	0.1	-1.0	-0.6	-0.7	0.7	-0.4	1.2
Commuting to job workplace: Cycle	0.7	0.8	3.8	0.4	0.1	-0.5	1.2	1.9	0.3	-0.0
Myopia	0.7	1.0	2.4	0.9	0.8	0.5	0.8	0.7	1.6	1.2
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.5	-1.9	1.7	1.5	1.0	-1.0	-0.4	-0.8
Cholesterol lowering medication	0.8	1.1	2.1	1.2	1.2	1.5	0.1	0.1	1.2	1.3
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.1	1.2	1.1	-0.1	1.4	0.9	1.0	1.3
Pain experienced in last month	0.3	0.4	1.6	0.7	-0.5	0.2	-1.3	0.0	-0.1	0.9
Supplements: Calcium	2.4	2.6	6.6	-2.0	-2.6	-1.5	-1.3	-0.6	-1.4	-1.2
Basal cell carcinoma (self-reported)	0.1	0.2	0.4	0.3	0.4	-0.4	-0.2	0.5	0.6	0.2
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.8	1.9	-0.1	1.1	0.5	1.8	1.9	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.9	-1.4	0.3	0.2	0.9	-0.8	0.2	-0.5
Heart disease (siblings)	0.4	0.5	2.0	0.3	0.2	-1.4	-0.3	0.6	-0.8	-0.3
Alcohol drinker status: Previous	2.4	2.7	6.0	1.7	-2.4	-1.7	-0.8	2.4	0.1	0.9
Pack years of smoking	0.4	0.5	2.6	1.6	-0.9	-0.2	-0.2	0.3	0.4	0.3
Impedance of whole body	0.4	2.1	6.3	-0.8	-2.5	-1.0	-1.1	0.1	-1.4	-1.8
Leg fat mass (left)	0.3	1.3	4.2	0.8	1.3	0.0	0.2	-2.1	0.6	1.5
Arm predicted mass (left)	1.7	8.6	20.2	1.3	4.5	3.3	1.7	-0.7	3.2	3.7