Hub : Genes

SNX30

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.0464 0.0214 7.2e-03 -0.002 NA -0.001 NA -0.002 7.3e-01 NA 4.4e-01 NA 6.9e-01
2 YFS Blood 0.0914 0.0200 3.6e-15 0.025 0.055 0.059 0.063 0.060 1.0e-08 1.4e-17 1.6e-18 6e-20 5.2e-19
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0260 0.0132 1.7e-03 0.019 0.008 0.001 NA 0.006 2.6e-03 3.8e-02 2.1e-01 NA 6.6e-02
4 TCGA Prostate Adenocarcinoma 0.0543 0.0325 5.2e-03 0.045 0.025 0.029 NA 0.035 1.7e-05 1.1e-03 4.3e-04 NA 1.3e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.3 0.5 1.2 0.5 -1.1 0.6 0.3
Bipolar Disorder or Schizophrenia 0.2 0.4 1.4 -0.2 -0.4 -0.4 1.2
Depressed Affect (Nagel 2018) 3.0 6.3 12.9 -2.7 0.0 -2.3 3.6
Depression (Nagel 2018) 0.8 1.1 2.3 -1.0 1.1 -0.4 1.5
Intelligence (Savage-Jansen 2018) 2.4 7.3 16.7 2.2 -2.4 4.1 -1.3
Neuroticism (Nagel 2018) 4.1 9.6 19.2 -3.4 -0.5 -2.7 4.4
Schizophrenia (2018) 0.4 0.8 1.7 -0.6 0.4 -1.0 1.3
Schizophrenia vs Biploar Disorder 0.5 0.6 1.6 -0.7 -0.6 -1.3 0.2
Worry (Nagel 2018) 2.6 5.4 9.9 -2.5 -0.3 -2.3 3.1
Alzheimer’s Disease (in mother) 0.2 0.3 0.7 0.2 0.5 -0.3 -0.8
Alzheimer’s Disease (in father) 0.7 0.7 1.2 -0.5 0.9 -1.1 0.8
Alzheimer’s Disease (including proxy) 0.3 0.5 1.0 -0.2 0.9 -1.0 -0.3
Crohns Disease (2017) 2.9 6.3 13.5 -1.4 -3.7 -0.8 3.0
Irritable Bowel Disease (IBD) 3.0 7.1 16.6 -1.8 -2.8 -0.7 4.1
Ulcerative Colitis (UC) 1.8 3.4 11.9 -1.1 -0.6 -0.5 3.4
Major Depression (MDD) 0.5 0.6 1.3 -0.2 -1.2 0.4 1.0
Reaction Time 0.4 0.7 1.8 -1.0 1.3 -0.2 0.1
Verbal and Numeric Reasoning (VNR) 0.8 1.9 3.1 1.4 -0.3 1.6 -1.8
Breast Cancer 1.6 4.0 7.8 0.9 2.8 0.4 -2.6
Ovarian Cancer 0.4 0.6 1.2 0.0 1.1 0.9 0.6
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.5 0.8 1.2 -1.1 -1.0 0.2 1.0
Bipolar Disorder (2011) 0.9 0.9 2.5 -0.5 -0.9 0.0 1.6
Body Mass Index (BMI) (2010) 1.3 1.8 4.5 -0.0 0.8 -1.4 -2.1
Coronary Artery Disease (CAD) 0.1 0.1 0.2 -0.5 -0.3 -0.4 -0.1
Crohns Disease (2012) 2.2 3.6 9.8 -0.9 -3.1 0.2 1.9
Mean Putamen Volume 0.8 0.9 1.3 0.9 -1.1 1.0 -0.8
Fasting Glucose 1.2 1.4 2.8 1.0 0.9 1.1 -1.7
HbA1C 1.0 1.1 2.4 -1.3 -0.0 -1.6 -0.6
HDL Cholesterol 0.2 0.3 0.8 0.0 -0.9 -0.6 0.2
LDL Cholesterol 0.2 0.3 0.7 0.5 0.4 0.8 -0.4
Lupus 0.2 0.3 0.4 0.6 0.5 0.6 -0.5
Neuroticism (2016) 1.1 1.6 2.5 -1.6 -0.7 -1.4 1.3
Primary Biliary Cirrhosis 0.9 1.2 3.3 -1.0 -0.7 -0.2 1.8
Rheumatoid Arthritis 0.9 1.3 3.1 0.6 0.4 1.2 1.8
Schizophrenia (2014) 0.6 1.3 3.5 -1.1 0.3 -0.8 1.9
Triglycerides 0.4 0.6 1.5 -1.2 0.9 0.1 0.0
Type 2 Diabetes (T2D) (2012) 0.9 1.0 1.2 -1.0 0.8 -1.1 1.1
Ulcerative Colitis 1.2 1.7 5.5 -0.4 -0.9 0.6 2.3
Blood Eosinophil Count 0.5 4.0 10.9 -1.3 -1.9 -0.4 3.3
Blood Platelet Count 0.0 0.2 0.5 -0.0 -0.4 0.7 0.3
Blood Red Count 2.2 21.7 47.1 4.6 3.4 2.6 -6.9
Blood White Count 0.1 1.0 3.0 0.7 -0.7 -0.4 1.7
Heel T-Score 0.2 1.8 3.6 1.7 0.7 0.2 -1.9
BMI 0.4 2.4 7.7 -0.1 2.8 -1.3 -0.7
Height 0.4 7.3 14.3 -2.2 -2.8 -1.5 3.8
Waist Hip Ratio (WHR) 0.1 0.4 1.1 0.0 0.5 -0.6 1.1
Systolic Blood Pressure 1.1 5.7 13.3 2.3 1.5 1.4 -3.6
Smoking Status 1.0 2.3 3.9 -2.0 0.1 -2.0 1.1
Allergy or Eczema 0.1 0.3 0.7 0.2 -0.8 0.5 -0.2
Cardiovascular Disease 1.2 3.9 7.4 1.3 2.7 0.0 -2.5
Hypothyroidism (self reported) 0.2 0.4 0.6 -0.1 -0.8 0.8 -0.6
Respiratory disease 0.3 0.6 1.4 -0.6 -0.0 -0.8 1.2
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.7 0.5 -0.8 0.0 0.2
Lung FEV1/FVC ratio 0.4 2.1 4.8 -1.7 0.6 -0.7 2.2
Lung FVC 0.7 3.6 9.9 -0.7 -3.1 0.9 1.8
Neuroticism 2.4 5.7 13.0 -2.3 -0.2 -2.0 3.6
Chronotype (morning person) 1.5 3.5 5.2 -2.3 0.9 -2.3 1.7
Hair Pigment 0.1 1.6 3.5 1.0 1.9 -0.1 1.4
Tanning 0.2 2.1 5.6 -2.4 0.3 -1.6 0.7
Hand grip strength (left) 0.4 1.0 3.5 0.5 -0.2 -0.3 -1.9
Number of treatments/medications taken 0.1 0.2 0.5 0.7 -0.1 0.6 0.2
Average weekly spirits intake 0.3 0.4 1.2 0.5 -0.1 0.1 -1.1
Sensitivity / hurt feelings 2.8 4.7 12.8 -2.0 -0.2 -1.5 3.6
Frequency of depressed mood in last 2 weeks 1.2 1.7 3.5 -1.6 0.6 -0.8 1.9
Hearing difficulty/problems: Yes 0.3 0.5 1.6 1.3 0.4 0.4 -0.4
Relative age of first facial hair 0.1 0.2 0.6 0.5 -0.3 0.8 -0.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.6 0.0 -0.2 -0.5 0.8
Ever used hormone-replacement therapy (HRT) 0.3 0.3 1.0 0.2 -0.4 0.4 1.0
Ever had hysterectomy (womb removed) 0.6 0.6 1.6 -0.2 -1.3 0.5 0.8
Systolic blood pressure, automated reading 2.0 5.9 12.7 2.3 1.6 1.7 -3.6
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.7 1.1 -0.5 0.7 1.3
Angina 0.4 0.6 1.8 -0.6 1.3 -0.1 -0.4
Medication for hormone replacement therapy 1.8 2.0 3.3 1.2 -1.4 1.8 -1.1
Vitamin and mineral supplements 0.5 0.7 1.5 -1.1 -0.2 -1.2 -0.2
Supplements: Zinc 1.9 2.1 3.7 1.9 -0.5 1.9 -0.9
Medication: Co-codamol 1.0 1.2 1.9 1.2 1.4 -0.4 -1.1
Medication: Metformin 0.4 0.6 1.1 -0.8 -1.0 -0.5 0.6
Diabetes (father) 1.3 1.6 3.0 1.5 -0.9 1.7 -0.4
Diabetes (mother) 0.4 0.5 1.3 0.2 -1.2 0.6 -0.5
Severe depression (siblings) 0.2 0.2 0.6 0.2 0.5 0.2 0.8
Pack years adult smoking proportion 0.2 0.3 0.5 0.5 0.7 0.1 -0.5
Impedance of leg (right) 0.7 3.2 4.9 -1.8 1.6 -2.2 1.4
Leg fat-free mass (left) 0.0 0.2 0.2 0.5 -0.0 -0.4 -0.5
Trunk fat percentage 0.2 0.8 2.6 0.7 1.6 0.3 -0.3
Hand grip strength (right) 0.2 0.5 1.1 -0.5 -0.0 -0.8 -1.0
Townsend deprivation index at recruitment 0.3 0.4 0.8 0.6 0.5 -0.6 -0.9
Current tobacco smoking 0.8 1.3 3.0 -1.1 -0.6 -0.7 1.7
Average weekly fortified wine intake 0.0 0.0 0.1 0.2 -0.3 0.1 0.0
Maternal smoking around birth 0.5 0.7 1.7 -0.9 0.1 -1.3 -0.6
Fed-up feelings 1.4 2.6 5.4 -2.3 0.0 -1.5 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.9 1.7 -1.3 0.6 -1.1 0.5
Relative age voice broke 0.3 0.4 1.0 0.3 -0.3 1.0 0.6
Taking other prescription medications 0.4 0.6 1.1 -0.9 0.1 -0.8 1.0
Age when periods started (menarche) 0.2 0.5 1.8 0.3 -1.4 0.5 -0.1
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.2 -0.4 -0.6 0.6 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 3.3 0.4 0.9 -0.4 -1.8
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 6.1 -0.5 2.5 -0.7 0.1
Qualifications: CSEs or equivalent 2.1 2.8 6.1 -0.6 2.5 -2.1 0.1
Serious illness, injury or assault to yourself 2.7 3.2 10.0 -1.0 3.2 -1.4 -0.2
High blood pressure 0.7 2.0 3.9 1.0 1.8 0.0 -2.0
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.4 0.8 -0.7 1.2 -0.6
Multivitamins +/- minerals 0.5 0.6 2.2 0.4 1.5 0.3 -0.1
Stomach or abdominal pain in last month 1.2 1.5 2.8 -1.7 -0.6 -1.4 1.0
Supplements: Glucosamine 2.9 3.8 8.2 2.2 -1.3 2.9 0.1
Diverticular disease/diverticulitis (self-reported) 3.8 4.6 6.1 -2.5 -2.0 -1.8 2.2
Medication: Atenolol 0.3 0.3 0.7 -0.6 -0.4 -0.4 -0.8
Medication: Levothyroxine sodium 0.3 0.5 1.9 -0.2 1.4 -0.1 0.1
Sitting height 0.2 1.4 2.1 -1.0 -1.2 -1.1 1.4
Chronic bronchitis/emphysema (father) 1.5 1.7 4.4 -1.1 -1.1 -2.1 0.4
High blood pressure (mother) 0.2 0.2 0.7 -0.1 -0.4 0.2 -0.8
Body mass index (BMI) 0.3 1.4 4.2 0.8 2.0 0.2 -1.0
Impedance of leg (left) 0.5 2.3 3.5 -1.8 1.1 -1.9 1.2
Leg predicted mass (left) 0.0 0.2 0.3 0.4 -0.0 -0.5 -0.5
Trunk fat mass 0.2 0.9 2.6 0.9 1.6 0.2 -0.2
Waist circumference 0.3 0.9 3.3 0.6 1.8 0.2 -0.3
Number of incorrect matches in round 0.1 0.2 0.6 -0.1 0.1 -0.2 0.8
Past tobacco smoking 1.2 2.2 5.5 1.7 -0.5 2.4 -0.4
Alcohol usually taken with meals 0.9 1.4 3.1 -0.6 1.8 -1.4 -0.1
Nervous feelings 2.2 4.1 6.6 -2.6 0.5 -2.1 2.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.1 -0.6 0.6 -1.1 -0.2
Hearing difficulty/problems with background noise 0.4 0.6 1.1 -0.6 -0.6 -0.9 1.0
Hair/balding pattern: Pattern 2 0.0 0.0 0.0 0.0 -0.1 0.0 -0.0
Had menopause 0.6 0.7 1.3 -0.1 -1.1 0.7 1.0
Had other major operations 1.8 2.2 2.8 1.7 -1.5 1.5 -1.3
Forced vital capacity (FVC) 0.2 0.8 3.1 -0.0 -1.8 -0.2 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.5 0.2 1.2 -0.3 -1.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.3 1.1 -0.0 1.0 0.0
Qualifications: None of the above 0.1 0.1 0.3 0.0 -0.6 0.1 0.5
Financial difficulties in last 2 years 0.4 0.6 0.9 -0.9 1.0 -0.2 -0.8
Mouth/teeth dental problems 0.5 0.7 1.8 -0.3 -1.3 -0.6 -0.7
Heart attack 1.3 1.7 2.7 1.0 1.6 0.8 -1.6
Allergy 0.1 0.2 0.6 -0.1 0.8 -0.5 -0.2
Pain all over the body in last month 2.6 2.8 6.6 -1.7 2.6 -1.2 -0.4
Diabetes (self-reported) 0.2 0.3 1.2 -0.0 -1.1 -0.2 -0.0
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 2.8 -1.7 -0.9 -1.4 1.4
Medication: Ramipril 0.9 1.1 2.3 -1.4 0.4 -1.5 -0.5
Medication: Simvastatin 0.6 0.9 2.8 0.2 0.7 -0.5 -1.7
Fluid intelligence score 0.9 1.8 3.4 1.8 0.1 0.8 -1.8
Illnesses of siblings 0.2 0.3 0.6 -0.2 -0.7 -0.5 0.8
Neuroticism score 3.5 7.4 10.3 -3.2 0.4 -3.0 3.2
Weight 0.1 0.4 1.2 0.4 1.1 -0.3 -0.2
Impedance of arm (right) 0.1 0.6 1.0 -0.5 -0.6 1.0 0.8
Arm fat percentage (right) 0.4 1.7 4.1 1.0 2.0 1.0 -0.9
Trunk fat-free mass 0.1 0.3 1.1 0.2 0.2 -1.1 -0.2
Hip circumference 0.3 1.4 5.4 0.1 2.3 -0.4 -0.3
Time employed in main current job 0.6 0.7 2.1 1.4 -0.2 0.9 0.3
Alcohol intake versus 10 years previously 0.0 0.1 0.2 -0.5 -0.0 0.0 -0.2
Father’s age at death 0.7 0.9 1.7 -0.9 -0.5 -1.3 1.0
Worrier / anxious feelings 0.9 1.6 4.7 -0.9 -0.2 -1.0 2.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 1.8 -1.0 -1.0 -1.0 1.3
Falls in the last year 0.8 1.0 2.6 1.2 -0.2 1.6 0.1
Hair/balding pattern: Pattern 3 0.4 0.6 0.9 0.8 -0.6 1.0 0.8
Number of live births 0.7 1.0 3.3 1.8 0.7 0.1 -0.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.4 -0.3 -1.2 -0.5 0.4
Pulse rate 0.7 1.1 3.5 -0.3 -0.5 -1.9 0.8
Happiness 0.4 0.5 1.4 -0.5 1.2 -0.7 0.0
Noisy workplace 0.1 0.1 0.2 0.3 0.0 -0.5 -0.1
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.7 0.5 -1.3 1.2 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.4 0.5 -0.4 1.2 -0.5
Mouth/teeth dental problems: Dentures 1.3 2.2 3.2 -1.8 1.4 -1.8 0.8
Asthma 0.3 0.5 1.9 -0.2 -0.4 -0.1 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.2 0.1 0.3 0.8 -1.1
Medication: Cholesterol lowering 0.5 0.8 2.9 -0.1 1.7 -0.0 -0.7
Depression (self-reported) 0.9 1.0 2.0 -0.7 1.4 -1.3 0.2
Medication: Lansoprazole 0.2 0.2 0.8 -0.9 -0.3 -0.3 0.0
Prospective memory result 0.1 0.1 0.4 -0.2 0.3 -0.6 0.1
Lung cancer (father) 2.6 3.1 8.5 0.6 -2.9 1.9 0.3
Illnesses of mother 0.4 0.5 1.1 -0.3 0.4 -1.0 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 1.9 -1.1 -0.8 -0.7 1.4
Pulse wave Arterial Stiffness index 2.0 2.3 3.0 1.7 1.2 1.4 -1.7
Impedance of arm (left) 0.2 1.0 1.8 -0.3 -0.8 1.1 1.3
Arm fat mass (right) 0.3 1.1 3.2 0.8 1.8 0.4 -0.6
Trunk predicted mass 0.0 0.3 0.9 0.2 0.2 -1.0 -0.0
Standing height 0.2 2.2 3.2 -0.9 -1.8 -1.3 1.8
Length of working week for main job 3.7 4.1 5.7 -2.2 1.5 -2.4 1.8
Exposure to tobacco smoke at home 0.7 0.8 1.7 0.3 1.0 0.6 -1.3
Breastfed as a baby 1.7 2.1 3.7 1.8 1.1 0.6 -1.9
Tense / ‘highly strung’ 1.9 3.1 5.4 -2.3 0.9 -2.1 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.1 -0.4 0.5 -0.7 1.0
Hair/balding pattern: Pattern 4 0.3 0.7 0.9 -0.7 0.8 -0.9 -1.0
Birth weight of first child 2.1 3.8 6.7 -1.9 -1.1 -1.9 2.6
Peak expiratory flow (PEF) 0.1 0.3 0.5 -0.5 -0.7 -0.2 -0.5
Pulse wave reflection index 2.6 3.2 5.4 0.9 2.3 1.9 -1.7
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.8 0.2 0.9 0.4 -0.3
Loud music exposure frequency 0.5 0.6 1.7 0.0 -0.2 0.7 -1.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.6 0.7 0.1 -0.5 -0.3
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 1.6 1.1 1.0 1.3 -0.3
Blood clot in the leg (DVT) 0.5 0.6 1.1 1.0 -0.2 1.0 -0.5
Medication: Paracetamol 0.1 0.2 0.5 0.7 0.2 0.5 -0.4
Headache pain in last month 0.1 0.2 0.6 0.0 -0.4 0.4 0.8
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 3.2 0.3 -1.8 0.6 0.6
Glaucoma (self-reported) 1.3 1.5 4.5 -0.9 -2.1 0.1 0.9
Gout (self-reported) 1.0 1.3 3.0 -0.9 1.2 -0.0 1.7
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.0 -1.0 -0.4 0.0 0.3
Medication: Amlodipine 0.3 0.5 1.8 0.0 0.1 -1.4 0.1
Medication: Ventolin 100micrograms inhaler 1.2 1.5 3.1 -1.8 0.4 -1.1 1.2
Birth weight 0.3 0.6 1.8 0.2 -1.4 0.5 -0.3
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.6 1.0 -0.5 1.3 -0.6
High blood pressure (siblings) 0.1 0.2 0.5 -0.1 0.1 0.7 0.5
Forced vital capacity (FVC), Best measure 0.4 1.5 1.9 -1.2 -1.0 -1.3 1.4
Body fat percentage 0.3 1.1 4.0 0.6 2.0 0.2 -0.5
Leg fat percentage (right) 0.7 2.5 9.4 0.2 3.1 -0.6 -0.4
Arm fat-free mass (right) 0.1 0.6 2.3 -0.0 0.3 -1.5 0.1
Exposure to tobacco smoke outside home 1.1 1.5 2.5 0.1 1.5 -1.1 -1.6
Comparative body size at age 10 0.2 0.5 1.1 -0.1 0.9 0.2 -1.0
Number of full brothers 1.2 1.5 4.7 -0.6 -0.6 -2.2 -0.7
Worry too long after embarrassment 1.0 1.7 2.8 -1.3 0.3 -1.4 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.6 -0.2 -0.8 -0.5 0.1
Wheeze or whistling in the chest in last year 0.2 0.4 1.5 0.2 1.2 -0.3 -0.3
Number of children fathered 0.3 0.3 0.7 -0.2 -0.9 0.8 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.1 -0.8 0.3 -1.0 -0.9
Age at first live birth 0.1 0.2 0.7 0.0 -0.1 0.6 -0.8
Pulse wave peak to peak time 2.5 2.9 4.2 -1.9 -1.4 -1.4 2.0
Health satisfaction 1.3 1.7 3.3 -1.1 1.4 -1.8 -0.3
Shortness of breath walking on level ground 1.8 2.1 2.9 -1.6 -1.7 -1.3 1.1
Qualifications: College or University degree 0.6 1.8 2.9 0.8 -1.6 1.7 -1.0
Eye problems/disorders: None of the above 0.3 0.3 1.0 -0.3 1.0 -0.5 0.1
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.4 -0.1 0.4 0.4 1.6
Emphysema/chronic bronchitis 0.8 0.9 2.2 -1.5 -0.5 -1.0 0.2
Medication for pain relief, constipation, heartburn 0.2 0.4 1.0 -0.3 -0.7 -0.1 1.0
Neck or shoulder pain in last month 1.0 1.5 3.0 0.1 -1.7 0.3 1.7
Medication: Blood pressure 0.2 0.3 0.6 -0.6 0.5 -0.8 0.2
Angina (self-reported) 0.4 0.5 1.2 -0.9 1.1 -0.2 -0.1
Migraine (self-reported) 0.1 0.1 0.2 -0.0 -0.4 -0.2 -0.4
Medication: Ibuprofen 0.2 0.3 0.6 0.2 0.3 0.8 -0.6
Medication: Allopurinol 0.4 0.5 1.4 -0.2 0.3 0.6 1.2
Medication: Omeprazole 1.3 1.5 1.9 -0.9 -1.3 -1.4 1.2
Medication: Seretide 50 evohaler 0.5 0.5 1.0 -1.0 0.5 -1.0 -0.1
Mean time to correctly identify matches 0.4 0.8 1.5 -1.2 0.8 -0.3 1.0
Heart disease (mother) 0.8 0.9 3.2 1.8 0.4 0.6 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 1.8 0.4 -1.2 1.3 -1.3
Whole body fat mass 0.2 0.9 2.9 0.7 1.7 0.0 -0.6
Leg fat mass (right) 0.3 1.3 4.6 0.2 2.1 -0.7 -0.5
Arm predicted mass (right) 0.1 0.6 2.2 0.1 0.4 -1.5 0.0
Pulse rate, automated reading 0.1 0.3 0.9 0.2 1.0 -0.2 0.4
Alcohol intake frequency. 0.4 1.0 3.0 -0.6 0.4 -0.8 1.7
Comparative height size at age 10 0.2 1.2 2.6 -0.9 -0.2 -1.1 1.6
Number of full sisters 0.6 0.7 2.0 -0.0 -1.4 -0.8 -0.6
Suffer from ‘nerves’ 0.6 0.9 1.6 -1.1 -0.5 -1.3 0.9
Overall health rating 1.2 2.7 5.8 -1.0 2.4 -2.0 0.2
Chest pain or discomfort 1.1 1.6 4.7 0.9 -2.2 0.8 -0.2
Had major operations 0.6 0.7 2.0 -0.5 1.4 -0.3 0.8
Age at last live birth 0.8 1.2 3.4 0.8 0.6 0.6 -1.8
Family relationship satisfaction 0.1 0.1 0.3 -0.2 -0.2 0.6 -0.0
Leg pain on walking 0.3 0.4 0.9 -0.0 0.8 -0.2 0.9
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 2.5 -1.2 1.6 -1.4 0.6
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.5 -0.0 0.4 -1.2 0.2
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.7 -0.2 -0.9 -0.2 1.3
Medication: Aspirin 1.1 1.5 3.2 -0.2 1.8 -0.6 -1.5
Supplements: Vitamin C 0.5 0.6 1.0 0.2 -0.5 1.0 1.0
Knee pain experienced in last month 0.0 0.0 0.1 -0.3 0.1 0.3 0.1
Hypertension (Self-reported) 0.6 1.7 3.0 0.9 1.7 -0.0 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.0 -0.6 -1.0 -0.8 0.9
Illnesses of father: Heart disease 0.6 0.9 2.3 0.2 1.0 0.5 -1.5
Illnesses of siblings: Diabetes 0.3 0.3 0.8 -0.1 0.7 -0.9 0.4
Smoking status: Previous 1.5 2.2 6.0 -1.6 0.5 -2.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.4 0.1 -0.5 -1.2 0.1
Whole body fat-free mass 0.0 0.2 0.7 0.3 0.0 -0.8 -0.3
Leg fat-free mass (right) 0.1 0.3 0.7 0.6 -0.6 -0.1 -0.8
Arm fat percentage (left) 0.4 1.6 3.8 1.0 1.9 0.9 -0.8
Average weekly red wine intake 0.1 0.2 0.3 0.3 -0.6 0.4 -0.6
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.6 -0.8 0.7 -0.6 -0.2
Mood swings 1.4 2.6 3.7 -1.9 0.7 -1.7 1.8
Loneliness, isolation 1.3 1.8 3.6 -1.6 -0.4 -1.9 1.0
Long-standing illness, disability or infirmity 0.6 0.9 2.1 -0.3 0.6 -1.4 -1.0
Ever had bowel cancer screening 0.5 0.6 1.3 0.4 -1.1 0.6 -0.8
Diabetes diagnosed by doctor 0.2 0.3 1.0 0.1 -1.0 0.3 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 1.8 1.0 -1.2 1.3 -0.5
Friendships satisfaction 0.4 0.5 1.4 -0.7 -0.4 -0.0 -1.2
Qualifications: nursing, teaching 0.4 0.6 1.6 0.2 -1.3 0.6 -0.7
Commuting to job workplace: Walk 0.7 0.7 1.7 0.5 -0.2 1.3 0.9
Eye problems/disorders: Cataract 0.4 0.4 1.2 -0.5 0.3 -1.1 0.5
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.8 1.1 -0.2 1.7 0.2
Medication for cholesterol 0.6 1.0 1.2 -0.7 1.0 -1.1 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.6 -0.2 -0.1 -1.6 -0.0
Back pain experienced in last month 1.0 1.4 2.8 1.0 1.7 -0.3 -1.3
Mineral and other dietary supplements 0.8 1.1 2.9 -0.9 0.7 -1.7 -0.5
Breast cancer (self-reported) 0.3 0.4 1.3 0.3 1.2 0.4 -0.1
Asthma (self-reported) 0.2 0.5 1.4 -0.3 -0.6 -0.2 1.2
Osteoporosis (self-reported) 0.7 0.9 3.3 0.3 1.8 -0.3 -0.1
Osteoarthritis (self-reported) 1.2 1.5 1.8 -1.3 1.3 -1.0 1.3
Medication: Aspirin 0.7 0.9 1.8 -0.3 1.1 -0.7 -1.3
Medication: Gliclazide 0.3 0.3 0.8 -0.3 -0.9 -0.2 0.6
Illnesses of father: None of the above (group 1) 0.3 0.3 1.0 0.1 -0.2 0.4 1.0
Smoking status: Current 0.6 1.0 2.4 -1.0 -0.3 -0.6 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.7 2.2 -0.4 -0.7 -0.4 1.5
Whole body water mass 0.0 0.2 0.7 0.3 0.0 -0.8 -0.3
Leg predicted mass (right) 0.1 0.3 0.5 0.6 -0.6 -0.1 -0.7
Arm fat mass (left) 0.3 1.0 3.5 0.6 1.9 0.2 -0.5
Number of self-reported non-cancer illnesses 0.8 1.3 2.7 -0.3 1.5 -1.6 -0.6
Average weekly champagne plus white wine intake 0.6 0.8 3.1 0.2 1.7 -0.1 -0.1
Miserableness 1.0 1.8 2.8 -1.4 0.2 -1.5 1.7
Guilty feelings 0.4 0.7 1.0 -1.0 -0.6 -0.9 0.7
Wears glasses or contact lenses 1.2 1.4 3.2 -0.4 -1.4 0.5 1.8
Ever taken oral contraceptive pill 0.5 0.5 1.6 -0.3 -0.3 -1.3 -0.5
Hearing aid user 0.5 0.6 1.3 -0.7 -0.6 -0.5 1.2
Mother’s age at death 1.0 1.3 3.7 0.8 -0.5 1.9 -0.7
Financial situation satisfaction 0.4 0.4 0.9 -1.0 0.0 -0.7 -0.6
Tinnitus: Yes, now most or all of the time 1.5 1.7 2.4 -1.4 -0.9 -1.2 1.6
Commuting to job workplace: Public transport 1.3 1.6 4.8 1.0 0.5 2.2 -0.4
Eye problems/disorders: Glaucoma 1.3 1.5 3.4 -0.1 -1.8 1.2 1.1
Medication: Blood pressure 0.5 0.9 2.0 0.6 0.2 1.1 -1.4
Pain type(s) experienced in last month: Hip pain 0.9 1.2 4.0 2.0 -0.5 0.7 -0.0
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.7 -0.4 -0.6 0.1 1.3
High cholesterol (Self-reported) 0.7 1.2 3.1 1.1 1.8 0.3 -0.7
Medication: Bendroflumethiazide 0.2 0.3 0.8 0.4 0.1 0.9 -0.5
Medication: Paracetamol 0.6 0.9 2.0 1.4 0.9 0.8 0.1
Medication: Lisinopril 0.5 0.7 1.9 1.4 -0.0 0.9 0.1
Medication: Atorvastatin 0.3 0.4 0.6 0.8 0.6 0.7 -0.2
Illnesses of father: High blood pressure 0.3 0.3 0.8 -0.0 0.3 -0.9 -0.7
Alcohol drinker status: Never 0.4 0.5 0.9 1.0 -0.6 0.9 -0.1
Ever smoked 0.4 0.6 1.4 -0.9 0.3 -1.2 0.5
Basal metabolic rate 0.0 0.2 0.5 0.3 0.3 -0.7 -0.4
Leg fat percentage (left) 0.5 2.0 7.5 0.3 2.7 -0.3 -0.6
Arm fat-free mass (left) 0.1 0.4 1.2 0.1 0.7 -1.1 -0.3
Number of operations (self-reported) 0.1 0.1 0.3 -0.2 -0.5 -0.3 0.3
Average weekly beer plus cider intake 0.4 0.6 2.1 0.4 0.3 -0.1 -1.4
Irritability 2.3 3.9 8.5 -2.9 1.0 -2.1 1.1
Risk taking 1.0 1.4 2.2 -1.5 1.4 -1.1 0.4
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.8 0.3 0.6 0.1 -0.9
Fractured/broken bones in last 5 years 0.8 1.1 3.9 0.1 2.0 0.1 0.5
Age started oral contraceptive pill 2.0 2.5 5.1 1.2 -2.3 1.8 -0.2
Diastolic blood pressure, automated reading 3.3 10.1 17.0 2.7 3.5 2.1 -4.1
Ever depressed for a whole week 0.2 0.2 0.3 0.5 0.6 0.5 0.3
Unable to work because of sickness or disability 1.3 1.7 3.3 -0.0 1.3 -1.3 -1.8
Commuting to job workplace: Cycle 2.8 3.4 5.8 2.2 -0.5 2.4 -1.6
Myopia 0.3 0.4 1.2 0.2 1.1 -0.1 -0.6
Vascular/heart problems diagnosed by doctor 1.4 3.7 7.1 -1.8 -2.1 -0.4 2.7
Cholesterol lowering medication 0.3 0.4 1.2 0.5 -0.1 0.4 -1.1
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 2.6 -0.9 -1.6 -1.2 1.4
Pain experienced in last month 1.0 1.6 3.6 -1.4 -0.8 -1.9 0.5
Supplements: Calcium 0.9 0.9 1.5 1.0 1.2 1.0 -0.5
Basal cell carcinoma (self-reported) 0.8 0.9 3.4 0.1 1.9 -0.1 -0.6
Heart attack/myocardial infarction (self-reported) 1.0 1.4 2.5 1.0 1.2 0.8 -1.6
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.6 0.8 -0.0 0.6 -0.4
Heart disease (siblings) 1.3 1.6 3.3 -1.8 1.6 -0.6 0.1
Alcohol drinker status: Previous 1.9 2.2 6.1 -0.9 1.3 -2.5 0.1
Pack years of smoking 0.1 0.1 0.3 0.4 0.5 0.1 -0.2
Impedance of whole body 0.1 0.6 1.5 -0.9 -0.2 -0.1 1.2
Leg fat mass (left) 0.3 1.2 4.3 0.3 2.1 -0.5 -0.4
Arm predicted mass (left) 0.1 0.4 0.9 0.2 0.7 -1.0 -0.3