Hub : Genes

SNX30

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0464	0.0214	7.2e-03	-0.002	NA	-0.001	NA	-0.002	7.3e-01	NA	4.4e-01	NA	6.9e-01
2	YFS	Blood	0.0914	0.0200	3.6e-15	0.025	0.055	0.059	0.063	0.060	1.0e-08	1.4e-17	1.6e-18	6e-20	5.2e-19
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0260	0.0132	1.7e-03	0.019	0.008	0.001	NA	0.006	2.6e-03	3.8e-02	2.1e-01	NA	6.6e-02
4	TCGA	Prostate Adenocarcinoma	0.0543	0.0325	5.2e-03	0.045	0.025	0.029	NA	0.035	1.7e-05	1.1e-03	4.3e-04	NA	1.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	1.2	0.5	-1.1	0.6	0.3
Bipolar Disorder or Schizophrenia	0.2	0.4	1.4	-0.2	-0.4	-0.4	1.2
Depressed Affect (Nagel 2018)	3.0	6.3	12.9	-2.7	0.0	-2.3	3.6
Depression (Nagel 2018)	0.8	1.1	2.3	-1.0	1.1	-0.4	1.5
Intelligence (Savage-Jansen 2018)	2.4	7.3	16.7	2.2	-2.4	4.1	-1.3
Neuroticism (Nagel 2018)	4.1	9.6	19.2	-3.4	-0.5	-2.7	4.4
Schizophrenia (2018)	0.4	0.8	1.7	-0.6	0.4	-1.0	1.3
Schizophrenia vs Biploar Disorder	0.5	0.6	1.6	-0.7	-0.6	-1.3	0.2
Worry (Nagel 2018)	2.6	5.4	9.9	-2.5	-0.3	-2.3	3.1
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	0.2	0.5	-0.3	-0.8
Alzheimer’s Disease (in father)	0.7	0.7	1.2	-0.5	0.9	-1.1	0.8
Alzheimer’s Disease (including proxy)	0.3	0.5	1.0	-0.2	0.9	-1.0	-0.3
Crohns Disease (2017)	2.9	6.3	13.5	-1.4	-3.7	-0.8	3.0
Irritable Bowel Disease (IBD)	3.0	7.1	16.6	-1.8	-2.8	-0.7	4.1
Ulcerative Colitis (UC)	1.8	3.4	11.9	-1.1	-0.6	-0.5	3.4
Major Depression (MDD)	0.5	0.6	1.3	-0.2	-1.2	0.4	1.0
Reaction Time	0.4	0.7	1.8	-1.0	1.3	-0.2	0.1
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.1	1.4	-0.3	1.6	-1.8
Breast Cancer	1.6	4.0	7.8	0.9	2.8	0.4	-2.6
Ovarian Cancer	0.4	0.6	1.2	0.0	1.1	0.9	0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.5	0.8	1.2	-1.1	-1.0	0.2	1.0
Bipolar Disorder (2011)	0.9	0.9	2.5	-0.5	-0.9	0.0	1.6
Body Mass Index (BMI) (2010)	1.3	1.8	4.5	-0.0	0.8	-1.4	-2.1
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.5	-0.3	-0.4	-0.1
Crohns Disease (2012)	2.2	3.6	9.8	-0.9	-3.1	0.2	1.9
Mean Putamen Volume	0.8	0.9	1.3	0.9	-1.1	1.0	-0.8
Fasting Glucose	1.2	1.4	2.8	1.0	0.9	1.1	-1.7
HbA1C	1.0	1.1	2.4	-1.3	-0.0	-1.6	-0.6
HDL Cholesterol	0.2	0.3	0.8	0.0	-0.9	-0.6	0.2
LDL Cholesterol	0.2	0.3	0.7	0.5	0.4	0.8	-0.4
Lupus	0.2	0.3	0.4	0.6	0.5	0.6	-0.5
Neuroticism (2016)	1.1	1.6	2.5	-1.6	-0.7	-1.4	1.3
Primary Biliary Cirrhosis	0.9	1.2	3.3	-1.0	-0.7	-0.2	1.8
Rheumatoid Arthritis	0.9	1.3	3.1	0.6	0.4	1.2	1.8
Schizophrenia (2014)	0.6	1.3	3.5	-1.1	0.3	-0.8	1.9
Triglycerides	0.4	0.6	1.5	-1.2	0.9	0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.2	-1.0	0.8	-1.1	1.1
Ulcerative Colitis	1.2	1.7	5.5	-0.4	-0.9	0.6	2.3
Blood Eosinophil Count	0.5	4.0	10.9	-1.3	-1.9	-0.4	3.3
Blood Platelet Count	0.0	0.2	0.5	-0.0	-0.4	0.7	0.3
Blood Red Count	2.2	21.7	47.1	4.6	3.4	2.6	-6.9
Blood White Count	0.1	1.0	3.0	0.7	-0.7	-0.4	1.7
Heel T-Score	0.2	1.8	3.6	1.7	0.7	0.2	-1.9
BMI	0.4	2.4	7.7	-0.1	2.8	-1.3	-0.7
Height	0.4	7.3	14.3	-2.2	-2.8	-1.5	3.8
Waist Hip Ratio (WHR)	0.1	0.4	1.1	0.0	0.5	-0.6	1.1
Systolic Blood Pressure	1.1	5.7	13.3	2.3	1.5	1.4	-3.6
Smoking Status	1.0	2.3	3.9	-2.0	0.1	-2.0	1.1
Allergy or Eczema	0.1	0.3	0.7	0.2	-0.8	0.5	-0.2
Cardiovascular Disease	1.2	3.9	7.4	1.3	2.7	0.0	-2.5
Hypothyroidism (self reported)	0.2	0.4	0.6	-0.1	-0.8	0.8	-0.6
Respiratory disease	0.3	0.6	1.4	-0.6	-0.0	-0.8	1.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	0.5	-0.8	0.0	0.2
Lung FEV1/FVC ratio	0.4	2.1	4.8	-1.7	0.6	-0.7	2.2
Lung FVC	0.7	3.6	9.9	-0.7	-3.1	0.9	1.8
Neuroticism	2.4	5.7	13.0	-2.3	-0.2	-2.0	3.6
Chronotype (morning person)	1.5	3.5	5.2	-2.3	0.9	-2.3	1.7
Hair Pigment	0.1	1.6	3.5	1.0	1.9	-0.1	1.4
Tanning	0.2	2.1	5.6	-2.4	0.3	-1.6	0.7
Hand grip strength (left)	0.4	1.0	3.5	0.5	-0.2	-0.3	-1.9
Number of treatments/medications taken	0.1	0.2	0.5	0.7	-0.1	0.6	0.2
Average weekly spirits intake	0.3	0.4	1.2	0.5	-0.1	0.1	-1.1
Sensitivity / hurt feelings	2.8	4.7	12.8	-2.0	-0.2	-1.5	3.6
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.5	-1.6	0.6	-0.8	1.9
Hearing difficulty/problems: Yes	0.3	0.5	1.6	1.3	0.4	0.4	-0.4
Relative age of first facial hair	0.1	0.2	0.6	0.5	-0.3	0.8	-0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	0.0	-0.2	-0.5	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.0	0.2	-0.4	0.4	1.0
Ever had hysterectomy (womb removed)	0.6	0.6	1.6	-0.2	-1.3	0.5	0.8
Systolic blood pressure, automated reading	2.0	5.9	12.7	2.3	1.6	1.7	-3.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.7	1.1	-0.5	0.7	1.3
Angina	0.4	0.6	1.8	-0.6	1.3	-0.1	-0.4
Medication for hormone replacement therapy	1.8	2.0	3.3	1.2	-1.4	1.8	-1.1
Vitamin and mineral supplements	0.5	0.7	1.5	-1.1	-0.2	-1.2	-0.2
Supplements: Zinc	1.9	2.1	3.7	1.9	-0.5	1.9	-0.9
Medication: Co-codamol	1.0	1.2	1.9	1.2	1.4	-0.4	-1.1
Medication: Metformin	0.4	0.6	1.1	-0.8	-1.0	-0.5	0.6
Diabetes (father)	1.3	1.6	3.0	1.5	-0.9	1.7	-0.4
Diabetes (mother)	0.4	0.5	1.3	0.2	-1.2	0.6	-0.5
Severe depression (siblings)	0.2	0.2	0.6	0.2	0.5	0.2	0.8
Pack years adult smoking proportion	0.2	0.3	0.5	0.5	0.7	0.1	-0.5
Impedance of leg (right)	0.7	3.2	4.9	-1.8	1.6	-2.2	1.4
Leg fat-free mass (left)	0.0	0.2	0.2	0.5	-0.0	-0.4	-0.5
Trunk fat percentage	0.2	0.8	2.6	0.7	1.6	0.3	-0.3
Hand grip strength (right)	0.2	0.5	1.1	-0.5	-0.0	-0.8	-1.0
Townsend deprivation index at recruitment	0.3	0.4	0.8	0.6	0.5	-0.6	-0.9
Current tobacco smoking	0.8	1.3	3.0	-1.1	-0.6	-0.7	1.7
Average weekly fortified wine intake	0.0	0.0	0.1	0.2	-0.3	0.1	0.0
Maternal smoking around birth	0.5	0.7	1.7	-0.9	0.1	-1.3	-0.6
Fed-up feelings	1.4	2.6	5.4	-2.3	0.0	-1.5	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.9	1.7	-1.3	0.6	-1.1	0.5
Relative age voice broke	0.3	0.4	1.0	0.3	-0.3	1.0	0.6
Taking other prescription medications	0.4	0.6	1.1	-0.9	0.1	-0.8	1.0
Age when periods started (menarche)	0.2	0.5	1.8	0.3	-1.4	0.5	-0.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	-0.4	-0.6	0.6	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.3	0.4	0.9	-0.4	-1.8
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	6.1	-0.5	2.5	-0.7	0.1
Qualifications: CSEs or equivalent	2.1	2.8	6.1	-0.6	2.5	-2.1	0.1
Serious illness, injury or assault to yourself	2.7	3.2	10.0	-1.0	3.2	-1.4	-0.2
High blood pressure	0.7	2.0	3.9	1.0	1.8	0.0	-2.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.4	0.8	-0.7	1.2	-0.6
Multivitamins +/- minerals	0.5	0.6	2.2	0.4	1.5	0.3	-0.1
Stomach or abdominal pain in last month	1.2	1.5	2.8	-1.7	-0.6	-1.4	1.0
Supplements: Glucosamine	2.9	3.8	8.2	2.2	-1.3	2.9	0.1
Diverticular disease/diverticulitis (self-reported)	3.8	4.6	6.1	-2.5	-2.0	-1.8	2.2
Medication: Atenolol	0.3	0.3	0.7	-0.6	-0.4	-0.4	-0.8
Medication: Levothyroxine sodium	0.3	0.5	1.9	-0.2	1.4	-0.1	0.1
Sitting height	0.2	1.4	2.1	-1.0	-1.2	-1.1	1.4
Chronic bronchitis/emphysema (father)	1.5	1.7	4.4	-1.1	-1.1	-2.1	0.4
High blood pressure (mother)	0.2	0.2	0.7	-0.1	-0.4	0.2	-0.8
Body mass index (BMI)	0.3	1.4	4.2	0.8	2.0	0.2	-1.0
Impedance of leg (left)	0.5	2.3	3.5	-1.8	1.1	-1.9	1.2
Leg predicted mass (left)	0.0	0.2	0.3	0.4	-0.0	-0.5	-0.5
Trunk fat mass	0.2	0.9	2.6	0.9	1.6	0.2	-0.2
Waist circumference	0.3	0.9	3.3	0.6	1.8	0.2	-0.3
Number of incorrect matches in round	0.1	0.2	0.6	-0.1	0.1	-0.2	0.8
Past tobacco smoking	1.2	2.2	5.5	1.7	-0.5	2.4	-0.4
Alcohol usually taken with meals	0.9	1.4	3.1	-0.6	1.8	-1.4	-0.1
Nervous feelings	2.2	4.1	6.6	-2.6	0.5	-2.1	2.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	-0.6	0.6	-1.1	-0.2
Hearing difficulty/problems with background noise	0.4	0.6	1.1	-0.6	-0.6	-0.9	1.0
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.0	-0.1	0.0	-0.0
Had menopause	0.6	0.7	1.3	-0.1	-1.1	0.7	1.0
Had other major operations	1.8	2.2	2.8	1.7	-1.5	1.5	-1.3
Forced vital capacity (FVC)	0.2	0.8	3.1	-0.0	-1.8	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.5	0.2	1.2	-0.3	-1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	1.1	-0.0	1.0	0.0
Qualifications: None of the above	0.1	0.1	0.3	0.0	-0.6	0.1	0.5
Financial difficulties in last 2 years	0.4	0.6	0.9	-0.9	1.0	-0.2	-0.8
Mouth/teeth dental problems	0.5	0.7	1.8	-0.3	-1.3	-0.6	-0.7
Heart attack	1.3	1.7	2.7	1.0	1.6	0.8	-1.6
Allergy	0.1	0.2	0.6	-0.1	0.8	-0.5	-0.2
Pain all over the body in last month	2.6	2.8	6.6	-1.7	2.6	-1.2	-0.4
Diabetes (self-reported)	0.2	0.3	1.2	-0.0	-1.1	-0.2	-0.0
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	2.8	-1.7	-0.9	-1.4	1.4
Medication: Ramipril	0.9	1.1	2.3	-1.4	0.4	-1.5	-0.5
Medication: Simvastatin	0.6	0.9	2.8	0.2	0.7	-0.5	-1.7
Fluid intelligence score	0.9	1.8	3.4	1.8	0.1	0.8	-1.8
Illnesses of siblings	0.2	0.3	0.6	-0.2	-0.7	-0.5	0.8
Neuroticism score	3.5	7.4	10.3	-3.2	0.4	-3.0	3.2
Weight	0.1	0.4	1.2	0.4	1.1	-0.3	-0.2
Impedance of arm (right)	0.1	0.6	1.0	-0.5	-0.6	1.0	0.8
Arm fat percentage (right)	0.4	1.7	4.1	1.0	2.0	1.0	-0.9
Trunk fat-free mass	0.1	0.3	1.1	0.2	0.2	-1.1	-0.2
Hip circumference	0.3	1.4	5.4	0.1	2.3	-0.4	-0.3
Time employed in main current job	0.6	0.7	2.1	1.4	-0.2	0.9	0.3
Alcohol intake versus 10 years previously	0.0	0.1	0.2	-0.5	-0.0	0.0	-0.2
Father’s age at death	0.7	0.9	1.7	-0.9	-0.5	-1.3	1.0
Worrier / anxious feelings	0.9	1.6	4.7	-0.9	-0.2	-1.0	2.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	1.8	-1.0	-1.0	-1.0	1.3
Falls in the last year	0.8	1.0	2.6	1.2	-0.2	1.6	0.1
Hair/balding pattern: Pattern 3	0.4	0.6	0.9	0.8	-0.6	1.0	0.8
Number of live births	0.7	1.0	3.3	1.8	0.7	0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.4	-0.3	-1.2	-0.5	0.4
Pulse rate	0.7	1.1	3.5	-0.3	-0.5	-1.9	0.8
Happiness	0.4	0.5	1.4	-0.5	1.2	-0.7	0.0
Noisy workplace	0.1	0.1	0.2	0.3	0.0	-0.5	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.7	0.5	-1.3	1.2	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.4	0.5	-0.4	1.2	-0.5
Mouth/teeth dental problems: Dentures	1.3	2.2	3.2	-1.8	1.4	-1.8	0.8
Asthma	0.3	0.5	1.9	-0.2	-0.4	-0.1	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.2	0.1	0.3	0.8	-1.1
Medication: Cholesterol lowering	0.5	0.8	2.9	-0.1	1.7	-0.0	-0.7
Depression (self-reported)	0.9	1.0	2.0	-0.7	1.4	-1.3	0.2
Medication: Lansoprazole	0.2	0.2	0.8	-0.9	-0.3	-0.3	0.0
Prospective memory result	0.1	0.1	0.4	-0.2	0.3	-0.6	0.1
Lung cancer (father)	2.6	3.1	8.5	0.6	-2.9	1.9	0.3
Illnesses of mother	0.4	0.5	1.1	-0.3	0.4	-1.0	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.9	-1.1	-0.8	-0.7	1.4
Pulse wave Arterial Stiffness index	2.0	2.3	3.0	1.7	1.2	1.4	-1.7
Impedance of arm (left)	0.2	1.0	1.8	-0.3	-0.8	1.1	1.3
Arm fat mass (right)	0.3	1.1	3.2	0.8	1.8	0.4	-0.6
Trunk predicted mass	0.0	0.3	0.9	0.2	0.2	-1.0	-0.0
Standing height	0.2	2.2	3.2	-0.9	-1.8	-1.3	1.8
Length of working week for main job	3.7	4.1	5.7	-2.2	1.5	-2.4	1.8
Exposure to tobacco smoke at home	0.7	0.8	1.7	0.3	1.0	0.6	-1.3
Breastfed as a baby	1.7	2.1	3.7	1.8	1.1	0.6	-1.9
Tense / ‘highly strung’	1.9	3.1	5.4	-2.3	0.9	-2.1	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	-0.4	0.5	-0.7	1.0
Hair/balding pattern: Pattern 4	0.3	0.7	0.9	-0.7	0.8	-0.9	-1.0
Birth weight of first child	2.1	3.8	6.7	-1.9	-1.1	-1.9	2.6
Peak expiratory flow (PEF)	0.1	0.3	0.5	-0.5	-0.7	-0.2	-0.5
Pulse wave reflection index	2.6	3.2	5.4	0.9	2.3	1.9	-1.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.8	0.2	0.9	0.4	-0.3
Loud music exposure frequency	0.5	0.6	1.7	0.0	-0.2	0.7	-1.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	0.7	0.1	-0.5	-0.3
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	1.6	1.1	1.0	1.3	-0.3
Blood clot in the leg (DVT)	0.5	0.6	1.1	1.0	-0.2	1.0	-0.5
Medication: Paracetamol	0.1	0.2	0.5	0.7	0.2	0.5	-0.4
Headache pain in last month	0.1	0.2	0.6	0.0	-0.4	0.4	0.8
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.2	0.3	-1.8	0.6	0.6
Glaucoma (self-reported)	1.3	1.5	4.5	-0.9	-2.1	0.1	0.9
Gout (self-reported)	1.0	1.3	3.0	-0.9	1.2	-0.0	1.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.0	-1.0	-0.4	0.0	0.3
Medication: Amlodipine	0.3	0.5	1.8	0.0	0.1	-1.4	0.1
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.1	-1.8	0.4	-1.1	1.2
Birth weight	0.3	0.6	1.8	0.2	-1.4	0.5	-0.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.6	1.0	-0.5	1.3	-0.6
High blood pressure (siblings)	0.1	0.2	0.5	-0.1	0.1	0.7	0.5
Forced vital capacity (FVC), Best measure	0.4	1.5	1.9	-1.2	-1.0	-1.3	1.4
Body fat percentage	0.3	1.1	4.0	0.6	2.0	0.2	-0.5
Leg fat percentage (right)	0.7	2.5	9.4	0.2	3.1	-0.6	-0.4
Arm fat-free mass (right)	0.1	0.6	2.3	-0.0	0.3	-1.5	0.1
Exposure to tobacco smoke outside home	1.1	1.5	2.5	0.1	1.5	-1.1	-1.6
Comparative body size at age 10	0.2	0.5	1.1	-0.1	0.9	0.2	-1.0
Number of full brothers	1.2	1.5	4.7	-0.6	-0.6	-2.2	-0.7
Worry too long after embarrassment	1.0	1.7	2.8	-1.3	0.3	-1.4	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.2	-0.8	-0.5	0.1
Wheeze or whistling in the chest in last year	0.2	0.4	1.5	0.2	1.2	-0.3	-0.3
Number of children fathered	0.3	0.3	0.7	-0.2	-0.9	0.8	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.1	-0.8	0.3	-1.0	-0.9
Age at first live birth	0.1	0.2	0.7	0.0	-0.1	0.6	-0.8
Pulse wave peak to peak time	2.5	2.9	4.2	-1.9	-1.4	-1.4	2.0
Health satisfaction	1.3	1.7	3.3	-1.1	1.4	-1.8	-0.3
Shortness of breath walking on level ground	1.8	2.1	2.9	-1.6	-1.7	-1.3	1.1
Qualifications: College or University degree	0.6	1.8	2.9	0.8	-1.6	1.7	-1.0
Eye problems/disorders: None of the above	0.3	0.3	1.0	-0.3	1.0	-0.5	0.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.4	-0.1	0.4	0.4	1.6
Emphysema/chronic bronchitis	0.8	0.9	2.2	-1.5	-0.5	-1.0	0.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	-0.3	-0.7	-0.1	1.0
Neck or shoulder pain in last month	1.0	1.5	3.0	0.1	-1.7	0.3	1.7
Medication: Blood pressure	0.2	0.3	0.6	-0.6	0.5	-0.8	0.2
Angina (self-reported)	0.4	0.5	1.2	-0.9	1.1	-0.2	-0.1
Migraine (self-reported)	0.1	0.1	0.2	-0.0	-0.4	-0.2	-0.4
Medication: Ibuprofen	0.2	0.3	0.6	0.2	0.3	0.8	-0.6
Medication: Allopurinol	0.4	0.5	1.4	-0.2	0.3	0.6	1.2
Medication: Omeprazole	1.3	1.5	1.9	-0.9	-1.3	-1.4	1.2
Medication: Seretide 50 evohaler	0.5	0.5	1.0	-1.0	0.5	-1.0	-0.1
Mean time to correctly identify matches	0.4	0.8	1.5	-1.2	0.8	-0.3	1.0
Heart disease (mother)	0.8	0.9	3.2	1.8	0.4	0.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.8	0.4	-1.2	1.3	-1.3
Whole body fat mass	0.2	0.9	2.9	0.7	1.7	0.0	-0.6
Leg fat mass (right)	0.3	1.3	4.6	0.2	2.1	-0.7	-0.5
Arm predicted mass (right)	0.1	0.6	2.2	0.1	0.4	-1.5	0.0
Pulse rate, automated reading	0.1	0.3	0.9	0.2	1.0	-0.2	0.4
Alcohol intake frequency.	0.4	1.0	3.0	-0.6	0.4	-0.8	1.7
Comparative height size at age 10	0.2	1.2	2.6	-0.9	-0.2	-1.1	1.6
Number of full sisters	0.6	0.7	2.0	-0.0	-1.4	-0.8	-0.6
Suffer from ‘nerves’	0.6	0.9	1.6	-1.1	-0.5	-1.3	0.9
Overall health rating	1.2	2.7	5.8	-1.0	2.4	-2.0	0.2
Chest pain or discomfort	1.1	1.6	4.7	0.9	-2.2	0.8	-0.2
Had major operations	0.6	0.7	2.0	-0.5	1.4	-0.3	0.8
Age at last live birth	0.8	1.2	3.4	0.8	0.6	0.6	-1.8
Family relationship satisfaction	0.1	0.1	0.3	-0.2	-0.2	0.6	-0.0
Leg pain on walking	0.3	0.4	0.9	-0.0	0.8	-0.2	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	2.5	-1.2	1.6	-1.4	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.5	-0.0	0.4	-1.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.7	-0.2	-0.9	-0.2	1.3
Medication: Aspirin	1.1	1.5	3.2	-0.2	1.8	-0.6	-1.5
Supplements: Vitamin C	0.5	0.6	1.0	0.2	-0.5	1.0	1.0
Knee pain experienced in last month	0.0	0.0	0.1	-0.3	0.1	0.3	0.1
Hypertension (Self-reported)	0.6	1.7	3.0	0.9	1.7	-0.0	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.0	-0.6	-1.0	-0.8	0.9
Illnesses of father: Heart disease	0.6	0.9	2.3	0.2	1.0	0.5	-1.5
Illnesses of siblings: Diabetes	0.3	0.3	0.8	-0.1	0.7	-0.9	0.4
Smoking status: Previous	1.5	2.2	6.0	-1.6	0.5	-2.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.4	0.1	-0.5	-1.2	0.1
Whole body fat-free mass	0.0	0.2	0.7	0.3	0.0	-0.8	-0.3
Leg fat-free mass (right)	0.1	0.3	0.7	0.6	-0.6	-0.1	-0.8
Arm fat percentage (left)	0.4	1.6	3.8	1.0	1.9	0.9	-0.8
Average weekly red wine intake	0.1	0.2	0.3	0.3	-0.6	0.4	-0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	-0.8	0.7	-0.6	-0.2
Mood swings	1.4	2.6	3.7	-1.9	0.7	-1.7	1.8
Loneliness, isolation	1.3	1.8	3.6	-1.6	-0.4	-1.9	1.0
Long-standing illness, disability or infirmity	0.6	0.9	2.1	-0.3	0.6	-1.4	-1.0
Ever had bowel cancer screening	0.5	0.6	1.3	0.4	-1.1	0.6	-0.8
Diabetes diagnosed by doctor	0.2	0.3	1.0	0.1	-1.0	0.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.8	1.0	-1.2	1.3	-0.5
Friendships satisfaction	0.4	0.5	1.4	-0.7	-0.4	-0.0	-1.2
Qualifications: nursing, teaching	0.4	0.6	1.6	0.2	-1.3	0.6	-0.7
Commuting to job workplace: Walk	0.7	0.7	1.7	0.5	-0.2	1.3	0.9
Eye problems/disorders: Cataract	0.4	0.4	1.2	-0.5	0.3	-1.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.8	1.1	-0.2	1.7	0.2
Medication for cholesterol	0.6	1.0	1.2	-0.7	1.0	-1.1	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.6	-0.2	-0.1	-1.6	-0.0
Back pain experienced in last month	1.0	1.4	2.8	1.0	1.7	-0.3	-1.3
Mineral and other dietary supplements	0.8	1.1	2.9	-0.9	0.7	-1.7	-0.5
Breast cancer (self-reported)	0.3	0.4	1.3	0.3	1.2	0.4	-0.1
Asthma (self-reported)	0.2	0.5	1.4	-0.3	-0.6	-0.2	1.2
Osteoporosis (self-reported)	0.7	0.9	3.3	0.3	1.8	-0.3	-0.1
Osteoarthritis (self-reported)	1.2	1.5	1.8	-1.3	1.3	-1.0	1.3
Medication: Aspirin	0.7	0.9	1.8	-0.3	1.1	-0.7	-1.3
Medication: Gliclazide	0.3	0.3	0.8	-0.3	-0.9	-0.2	0.6
Illnesses of father: None of the above (group 1)	0.3	0.3	1.0	0.1	-0.2	0.4	1.0
Smoking status: Current	0.6	1.0	2.4	-1.0	-0.3	-0.6	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.7	2.2	-0.4	-0.7	-0.4	1.5
Whole body water mass	0.0	0.2	0.7	0.3	0.0	-0.8	-0.3
Leg predicted mass (right)	0.1	0.3	0.5	0.6	-0.6	-0.1	-0.7
Arm fat mass (left)	0.3	1.0	3.5	0.6	1.9	0.2	-0.5
Number of self-reported non-cancer illnesses	0.8	1.3	2.7	-0.3	1.5	-1.6	-0.6
Average weekly champagne plus white wine intake	0.6	0.8	3.1	0.2	1.7	-0.1	-0.1
Miserableness	1.0	1.8	2.8	-1.4	0.2	-1.5	1.7
Guilty feelings	0.4	0.7	1.0	-1.0	-0.6	-0.9	0.7
Wears glasses or contact lenses	1.2	1.4	3.2	-0.4	-1.4	0.5	1.8
Ever taken oral contraceptive pill	0.5	0.5	1.6	-0.3	-0.3	-1.3	-0.5
Hearing aid user	0.5	0.6	1.3	-0.7	-0.6	-0.5	1.2
Mother’s age at death	1.0	1.3	3.7	0.8	-0.5	1.9	-0.7
Financial situation satisfaction	0.4	0.4	0.9	-1.0	0.0	-0.7	-0.6
Tinnitus: Yes, now most or all of the time	1.5	1.7	2.4	-1.4	-0.9	-1.2	1.6
Commuting to job workplace: Public transport	1.3	1.6	4.8	1.0	0.5	2.2	-0.4
Eye problems/disorders: Glaucoma	1.3	1.5	3.4	-0.1	-1.8	1.2	1.1
Medication: Blood pressure	0.5	0.9	2.0	0.6	0.2	1.1	-1.4
Pain type(s) experienced in last month: Hip pain	0.9	1.2	4.0	2.0	-0.5	0.7	-0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.7	-0.4	-0.6	0.1	1.3
High cholesterol (Self-reported)	0.7	1.2	3.1	1.1	1.8	0.3	-0.7
Medication: Bendroflumethiazide	0.2	0.3	0.8	0.4	0.1	0.9	-0.5
Medication: Paracetamol	0.6	0.9	2.0	1.4	0.9	0.8	0.1
Medication: Lisinopril	0.5	0.7	1.9	1.4	-0.0	0.9	0.1
Medication: Atorvastatin	0.3	0.4	0.6	0.8	0.6	0.7	-0.2
Illnesses of father: High blood pressure	0.3	0.3	0.8	-0.0	0.3	-0.9	-0.7
Alcohol drinker status: Never	0.4	0.5	0.9	1.0	-0.6	0.9	-0.1
Ever smoked	0.4	0.6	1.4	-0.9	0.3	-1.2	0.5
Basal metabolic rate	0.0	0.2	0.5	0.3	0.3	-0.7	-0.4
Leg fat percentage (left)	0.5	2.0	7.5	0.3	2.7	-0.3	-0.6
Arm fat-free mass (left)	0.1	0.4	1.2	0.1	0.7	-1.1	-0.3
Number of operations (self-reported)	0.1	0.1	0.3	-0.2	-0.5	-0.3	0.3
Average weekly beer plus cider intake	0.4	0.6	2.1	0.4	0.3	-0.1	-1.4
Irritability	2.3	3.9	8.5	-2.9	1.0	-2.1	1.1
Risk taking	1.0	1.4	2.2	-1.5	1.4	-1.1	0.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	0.3	0.6	0.1	-0.9
Fractured/broken bones in last 5 years	0.8	1.1	3.9	0.1	2.0	0.1	0.5
Age started oral contraceptive pill	2.0	2.5	5.1	1.2	-2.3	1.8	-0.2
Diastolic blood pressure, automated reading	3.3	10.1	17.0	2.7	3.5	2.1	-4.1
Ever depressed for a whole week	0.2	0.2	0.3	0.5	0.6	0.5	0.3
Unable to work because of sickness or disability	1.3	1.7	3.3	-0.0	1.3	-1.3	-1.8
Commuting to job workplace: Cycle	2.8	3.4	5.8	2.2	-0.5	2.4	-1.6
Myopia	0.3	0.4	1.2	0.2	1.1	-0.1	-0.6
Vascular/heart problems diagnosed by doctor	1.4	3.7	7.1	-1.8	-2.1	-0.4	2.7
Cholesterol lowering medication	0.3	0.4	1.2	0.5	-0.1	0.4	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.6	-0.9	-1.6	-1.2	1.4
Pain experienced in last month	1.0	1.6	3.6	-1.4	-0.8	-1.9	0.5
Supplements: Calcium	0.9	0.9	1.5	1.0	1.2	1.0	-0.5
Basal cell carcinoma (self-reported)	0.8	0.9	3.4	0.1	1.9	-0.1	-0.6
Heart attack/myocardial infarction (self-reported)	1.0	1.4	2.5	1.0	1.2	0.8	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.8	-0.0	0.6	-0.4
Heart disease (siblings)	1.3	1.6	3.3	-1.8	1.6	-0.6	0.1
Alcohol drinker status: Previous	1.9	2.2	6.1	-0.9	1.3	-2.5	0.1
Pack years of smoking	0.1	0.1	0.3	0.4	0.5	0.1	-0.2
Impedance of whole body	0.1	0.6	1.5	-0.9	-0.2	-0.1	1.2
Leg fat mass (left)	0.3	1.2	4.3	0.3	2.1	-0.5	-0.4
Arm predicted mass (left)	0.1	0.4	0.9	0.2	0.7	-1.0	-0.3