Hub : Genes

TYSND1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.3210 0.0770 1.7e-04 0.190 NA 0.130 NA 0.175 7.6e-09 NA 2.2e-06 NA 3.4e-08
2 NTR Blood 0.0436 0.0119 6.4e-06 0.019 0.017 0.013 0.017 0.014 7.8e-07 3.2e-06 3.7e-05 1.9e-06 1.4e-05
3 ROSMAP Brain Pre-frontal Cortex 0.1546 0.0336 8.5e-09 0.081 0.080 0.100 0.115 0.111 1.2e-10 1.8e-10 9.2e-13 1.5e-14 3.7e-14
4 YFS Blood 0.2006 0.0297 0.0e+00 0.061 0.106 0.126 0.130 0.113 3.8e-19 6.6e-33 4.2e-39 3.4e-40 6.1e-35
5 TCGA Brain Lower Grade Glioma 0.0348 0.0151 1.2e-03 0.039 0.027 0.035 NA 0.035 2.9e-05 4.6e-04 6.5e-05 NA 6.8e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.2 1.9 2.9 0.2 1.3 1.5 1.6 1.7
Bipolar Disorder or Schizophrenia 0.3 0.8 1.5 0.8 -0.5 -1.2 -1.0 -0.7
Depressed Affect (Nagel 2018) 1.2 2.5 7.0 -0.9 -2.6 -1.4 -1.5 -0.6
Depression (Nagel 2018) 0.3 0.4 1.3 0.8 -1.1 -0.1 -0.3 0.4
Intelligence (Savage-Jansen 2018) 1.1 3.5 11.7 3.4 -0.9 0.0 -0.5 -2.2
Neuroticism (Nagel 2018) 0.4 0.9 2.2 -0.7 -1.5 -1.0 -0.9 -0.3
Schizophrenia (2018) 2.4 4.9 8.2 0.9 -1.8 -2.9 -2.6 -2.3
Schizophrenia vs Biploar Disorder 1.6 2.1 4.6 -1.1 -0.7 -2.0 -2.1 -0.4
Worry (Nagel 2018) 0.1 0.2 0.3 -0.5 -0.1 -0.5 -0.5 0.2
Alzheimer’s Disease (in mother) 1.5 1.8 3.0 -0.3 -1.7 -1.6 -1.1 -1.5
Alzheimer’s Disease (in father) 3.8 4.2 7.9 2.8 -2.8 0.0 -0.1 -2.2
Alzheimer’s Disease (including proxy) 2.7 4.0 10.1 0.7 -3.2 -1.3 -0.9 -2.6
Crohns Disease (2017) 0.6 1.2 1.9 -1.0 0.5 1.2 1.4 1.3
Irritable Bowel Disease (IBD) 0.5 1.1 2.6 -1.4 0.6 0.2 0.7 1.6
Ulcerative Colitis (UC) 0.3 0.6 1.5 -1.0 0.5 -0.6 0.0 1.2
Major Depression (MDD) 3.5 4.3 11.7 3.4 -1.6 0.5 0.1 -2.6
Reaction Time 1.0 1.8 4.9 0.1 -0.4 -2.2 -1.9 -0.8
Verbal and Numeric Reasoning (VNR) 0.6 1.4 4.5 2.1 -0.2 0.7 0.4 -1.3
Breast Cancer 1.3 3.0 7.0 -0.7 2.6 1.9 1.2 1.6
Ovarian Cancer 1.1 1.5 2.1 1.4 -1.1 -1.0 -1.0 -1.4
Prostate Cancer 0.4 0.6 1.8 -0.2 1.4 -0.5 -0.9 0.5
Age at First Birth 0.3 0.4 1.2 -1.1 0.4 -0.7 -0.1 -0.3
Bipolar Disorder (2011) 0.5 0.5 1.5 -0.5 -0.1 -1.2 -0.3 0.9
Body Mass Index (BMI) (2010) 0.2 0.3 0.8 -0.9 -0.4 -0.7 -0.4 -0.2
Coronary Artery Disease (CAD) 0.3 0.3 0.9 -0.3 -0.7 -0.9 0.0 -0.3
Crohns Disease (2012) 0.1 0.1 0.2 -0.3 0.3 -0.1 -0.2 0.4
Mean Putamen Volume 1.6 1.9 2.8 1.4 -1.2 -1.1 -1.3 -1.7
Fasting Glucose 0.3 0.3 1.4 0.3 1.2 -0.1 -0.4 0.2
HbA1C 1.2 1.4 2.5 1.3 0.5 1.6 1.4 0.6
HDL Cholesterol 1.5 2.5 5.2 1.8 -2.0 0.0 -0.4 -2.3
LDL Cholesterol 2.2 3.5 8.5 -1.3 -0.6 -2.9 -2.2 -1.4
Lupus 3.5 5.3 7.7 0.1 2.7 2.5 2.8 2.2
Neuroticism (2016) 0.4 0.5 0.9 -1.0 -0.6 -0.9 -0.5 -0.4
Primary Biliary Cirrhosis 0.3 0.4 0.6 0.8 -0.2 -0.7 -0.5 -0.6
Rheumatoid Arthritis 1.0 1.4 4.0 2.0 -1.1 0.3 0.4 -1.3
Schizophrenia (2014) 1.9 4.2 7.6 0.7 -1.5 -2.7 -2.8 -1.8
Triglycerides 1.0 1.6 4.1 -0.4 2.0 0.9 0.8 1.5
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.0 0.3 0.5 -1.0 -0.7 0.4
Ulcerative Colitis 0.1 0.2 0.6 -0.3 -0.4 -0.8 -0.4 0.1
Blood Eosinophil Count 0.3 2.3 5.2 -0.1 1.6 -2.3 -1.7 -0.9
Blood Platelet Count 0.0 0.3 0.6 0.7 0.6 -0.4 0.2 -0.5
Blood Red Count 1.5 14.2 27.6 2.1 -4.2 -3.1 -3.4 -5.2
Blood White Count 0.2 1.6 3.0 0.4 1.2 -1.6 -1.7 -0.8
Heel T-Score 0.3 2.7 5.0 -1.4 1.5 1.2 1.8 2.2
BMI 0.1 0.6 1.3 -0.5 0.9 0.4 0.6 1.1
Height 0.1 2.4 5.7 -0.2 1.9 2.4 1.3 1.2
Waist Hip Ratio (WHR) 0.1 0.2 1.0 1.0 0.3 0.1 -0.3 0.1
Systolic Blood Pressure 0.3 1.5 3.0 1.4 -1.3 0.7 0.5 -1.7
Smoking Status 0.1 0.3 0.7 0.1 0.9 -0.6 0.0 0.5
Allergy or Eczema 0.7 1.9 5.1 -2.3 1.4 -0.0 0.6 1.4
Cardiovascular Disease 0.6 2.1 4.3 2.1 0.3 1.5 1.4 -1.3
Hypothyroidism (self reported) 1.6 3.8 10.3 0.6 -1.7 -1.2 -2.0 -3.2
Respiratory disease 0.3 0.6 0.9 -0.8 0.8 1.0 0.3 0.9
Type 2 Diabetes (T2D) (2018) 0.9 1.8 6.6 -0.1 2.6 0.8 0.8 1.0
Lung FEV1/FVC ratio 1.6 8.4 18.9 -2.5 4.3 0.9 2.4 3.2
Lung FVC 0.1 0.7 1.4 -0.7 0.2 -1.2 -1.1 -0.6
Neuroticism 0.7 1.7 2.5 -1.4 -1.6 -1.4 -1.3 -0.1
Chronotype (morning person) 0.4 0.8 1.3 -1.1 -0.0 -0.7 -1.1 -1.1
Hair Pigment 0.1 2.7 5.5 -1.4 -0.9 -2.1 -2.4 -0.9
Tanning 0.1 1.1 1.7 1.2 1.0 1.3 1.2 0.2
Hand grip strength (left) 0.3 0.7 2.4 0.3 0.4 0.9 1.6 -0.5
Number of treatments/medications taken 0.9 1.7 3.7 1.9 0.6 1.3 1.5 -0.6
Average weekly spirits intake 0.1 0.1 0.2 0.4 -0.4 -0.3 -0.1 -0.2
Sensitivity / hurt feelings 0.5 0.9 2.1 -1.4 -1.5 -0.6 -0.4 -0.0
Frequency of depressed mood in last 2 weeks 0.4 0.6 2.6 -0.2 -1.6 -0.1 -0.3 0.6
Hearing difficulty/problems: Yes 2.7 4.1 5.6 2.4 -2.2 -1.3 -1.8 -2.2
Relative age of first facial hair 0.1 0.2 0.6 0.0 -0.5 0.4 -0.0 -0.8
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 2.2 1.5 -0.5 1.3 0.5 -0.6
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.8 0.4 0.7 0.5 0.3 1.7
Ever had hysterectomy (womb removed) 0.5 0.6 0.8 0.4 -0.8 -0.9 -0.7 -0.9
Systolic blood pressure, automated reading 0.1 0.4 0.7 0.4 -0.8 -0.1 -0.7 -0.8
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.4 -0.4 0.8 -1.5 -1.5 -0.5
Angina 1.1 1.4 2.9 0.4 1.1 1.7 1.5 0.7
Medication for hormone replacement therapy 0.5 0.6 1.7 1.3 0.5 0.5 0.1 0.9
Vitamin and mineral supplements 0.4 0.6 1.4 -0.7 0.5 -1.2 -0.5 0.8
Supplements: Zinc 0.6 0.6 2.3 0.7 1.5 -0.3 -0.5 -0.3
Medication: Co-codamol 0.3 0.4 0.6 -0.7 0.6 -0.8 -0.4 -0.5
Medication: Metformin 0.8 1.2 4.1 -0.7 2.0 0.2 0.6 0.9
Diabetes (father) 1.1 1.3 2.5 -1.6 0.7 1.1 1.2 1.0
Diabetes (mother) 2.1 2.7 7.6 -0.3 -0.6 -1.9 -2.8 -1.4
Severe depression (siblings) 1.3 1.4 4.2 -2.0 0.3 -0.5 0.6 1.5
Pack years adult smoking proportion 0.1 0.2 0.6 -0.8 -0.2 -0.4 0.0 0.4
Impedance of leg (right) 0.5 2.3 4.8 0.9 -2.0 2.2 -0.0 -1.3
Leg fat-free mass (left) 0.3 1.7 4.9 -1.2 2.2 -0.2 0.5 1.3
Trunk fat percentage 0.0 0.2 0.7 -0.0 0.3 0.4 -0.8 -0.0
Hand grip strength (right) 0.3 0.8 3.1 0.6 -0.4 -0.3 -0.1 -1.8
Townsend deprivation index at recruitment 0.8 1.1 1.8 1.3 -0.3 -1.3 -0.9 -1.1
Current tobacco smoking 2.1 3.4 5.8 0.7 -1.9 -2.4 -1.8 -1.9
Average weekly fortified wine intake 0.3 0.4 1.2 0.7 -0.2 0.0 0.1 -1.1
Maternal smoking around birth 0.8 1.2 2.8 -1.0 -0.5 -1.7 -1.2 -0.6
Fed-up feelings 0.7 1.3 4.5 -0.7 -2.1 -0.5 -0.8 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.7 -0.0 -0.8 -0.3 -0.6 0.6
Relative age voice broke 0.7 1.1 2.7 -1.6 1.3 -0.6 -0.8 0.5
Taking other prescription medications 0.5 0.7 1.2 -0.6 1.1 1.0 0.7 0.7
Age when periods started (menarche) 0.1 0.1 0.4 0.6 -0.0 -0.4 0.1 -0.4
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 4.2 2.1 -0.7 0.4 0.4 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.7 0.9 -0.4 -0.1 -0.2 0.1
Tinnitus: Yes, but not now, but have in the past 1.2 1.2 3.4 1.9 -0.4 1.3 1.0 0.1
Qualifications: CSEs or equivalent 0.8 1.1 1.9 -1.0 -0.2 1.1 1.2 1.4
Serious illness, injury or assault to yourself 0.3 0.3 0.5 0.6 0.6 0.6 0.7 0.3
High blood pressure 0.5 1.5 2.6 1.6 -0.3 1.6 0.9 -1.2
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.8 -1.3 0.8 0.5 1.0 0.5
Multivitamins +/- minerals 0.5 0.6 1.0 0.9 -0.7 0.7 0.6 -1.0
Stomach or abdominal pain in last month 1.7 2.1 5.0 -2.2 -1.4 -1.2 -1.3 -0.7
Supplements: Glucosamine 1.2 1.6 3.5 1.5 -0.9 -1.2 -0.2 -1.9
Diverticular disease/diverticulitis (self-reported) 2.4 2.8 4.5 -2.0 2.1 0.6 1.0 2.0
Medication: Atenolol 0.3 0.4 1.1 0.4 -0.3 -0.4 -0.5 -1.1
Medication: Levothyroxine sodium 3.5 5.9 12.2 0.0 -0.9 -2.8 -3.5 -2.9
Sitting height 0.4 2.6 5.8 0.1 2.4 1.7 1.8 0.9
Chronic bronchitis/emphysema (father) 0.5 0.6 1.3 -0.1 -0.7 -1.1 -0.1 -1.2
High blood pressure (mother) 0.4 0.5 1.0 -0.4 1.0 0.9 0.7 0.5
Body mass index (BMI) 0.3 1.1 2.0 -1.3 1.4 -0.5 -0.3 1.2
Impedance of leg (left) 0.5 2.6 5.3 1.2 -2.3 1.9 0.0 -1.6
Leg predicted mass (left) 0.3 1.6 4.8 -1.1 2.2 -0.2 0.5 1.3
Trunk fat mass 0.1 0.4 1.0 -0.5 1.0 0.7 -0.1 0.6
Waist circumference 0.2 0.6 1.3 -0.9 0.9 0.2 0.0 1.1
Number of incorrect matches in round 0.7 1.1 2.9 -1.7 0.7 -0.1 0.1 1.4
Past tobacco smoking 0.9 1.6 3.2 -0.4 -1.8 -1.3 -1.4 -1.1
Alcohol usually taken with meals 0.8 1.4 4.7 0.1 2.2 -0.6 -1.2 0.6
Nervous feelings 0.5 0.9 2.4 -1.5 0.4 -1.0 -0.5 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.0 -1.4 -0.5 -0.9 -0.9 0.9
Hearing difficulty/problems with background noise 1.5 2.5 4.6 2.1 -1.9 -0.7 -1.2 -1.6
Hair/balding pattern: Pattern 2 0.7 0.9 3.8 -1.9 -0.1 0.1 0.6 0.4
Had menopause 1.3 1.6 3.5 0.7 -0.7 -1.8 -1.9 -0.9
Had other major operations 0.9 1.1 3.2 1.8 0.2 0.4 0.8 -1.3
Forced vital capacity (FVC) 0.1 0.4 1.2 -1.1 0.8 0.2 0.4 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 1.1 1.1 -0.2 0.1 -0.0 0.4
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.0 0.8 -1.4 -0.8 -0.5 -1.3
Qualifications: None of the above 0.1 0.2 0.4 -0.1 0.2 0.4 0.7 0.5
Financial difficulties in last 2 years 0.1 0.2 0.3 -0.2 -0.6 -0.4 0.2 -0.5
Mouth/teeth dental problems 1.7 2.6 6.2 0.7 1.3 1.9 2.5 0.9
Heart attack 3.8 4.8 5.6 1.7 -2.3 -2.3 -2.2 -2.4
Allergy 0.5 1.2 3.8 2.0 -0.7 -0.5 -0.6 -1.1
Pain all over the body in last month 0.2 0.2 0.4 0.3 -0.6 -0.6 -0.4 -0.3
Diabetes (self-reported) 0.8 1.3 5.7 -0.1 2.4 -0.0 0.0 0.7
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 4.2 -2.0 0.3 -0.1 0.5 1.3
Medication: Ramipril 1.1 1.4 3.2 1.8 -1.0 0.2 -0.5 -1.7
Medication: Simvastatin 0.4 0.5 1.2 1.1 -0.5 -0.0 0.6 -0.9
Fluid intelligence score 0.9 1.9 4.7 2.2 -0.8 0.7 -0.2 -1.9
Illnesses of siblings 0.7 1.0 2.3 0.1 -1.1 -0.7 -1.5 -1.0
Neuroticism score 0.8 1.6 3.5 -1.9 -1.3 -1.4 -0.8 0.1
Weight 0.3 1.3 3.7 -1.0 1.9 0.6 0.6 1.2
Impedance of arm (right) 0.5 2.5 5.1 2.3 -1.4 1.2 -0.9 -1.7
Arm fat percentage (right) 0.1 0.5 1.2 -0.4 1.1 -0.2 -0.9 0.7
Trunk fat-free mass 0.4 2.4 5.1 -1.2 2.3 0.4 1.5 1.8
Hip circumference 0.1 0.2 0.4 -0.5 0.4 0.5 0.2 0.7
Time employed in main current job 0.3 0.3 1.2 -0.2 1.1 -0.1 0.3 0.6
Alcohol intake versus 10 years previously 1.1 1.6 3.2 1.0 -0.8 -1.5 -1.8 -0.9
Father’s age at death 1.0 1.3 2.1 -0.8 1.5 0.3 1.3 1.5
Worrier / anxious feelings 0.2 0.4 1.7 -1.3 0.2 0.1 -0.2 0.6
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 6.3 -0.0 -2.5 -0.8 -1.1 -0.9
Falls in the last year 0.6 0.8 1.6 -0.7 -0.5 -1.3 -0.7 -1.1
Hair/balding pattern: Pattern 3 0.4 0.5 1.1 1.1 -0.4 -0.8 -0.1 -0.9
Number of live births 0.6 0.9 3.1 1.8 -0.5 -0.4 -0.7 -0.8
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 5.4 -2.2 2.3 0.1 0.6 1.2
Pulse rate 1.1 1.9 4.0 -1.2 1.8 0.2 0.9 2.0
Happiness 0.3 0.3 0.9 0.4 -0.6 -0.3 -0.1 -1.0
Noisy workplace 0.4 0.5 1.3 -0.7 -0.3 -1.1 -0.3 0.9
Qualifications: A levels/AS levels or equivalent 0.7 1.5 4.0 -0.5 -0.4 2.0 1.2 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.2 -0.9 0.0 0.8 1.1 0.4
Mouth/teeth dental problems: Dentures 1.0 1.7 4.3 -1.4 -0.2 -1.5 -2.1 -0.1
Asthma 0.5 0.9 1.8 -1.3 0.3 1.3 0.5 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.3 0.3 0.3 -0.5 -0.6 0.1
Medication: Cholesterol lowering 2.9 4.6 9.6 3.1 -2.5 0.3 -0.1 -2.6
Depression (self-reported) 1.4 1.7 4.4 -1.8 0.8 -0.4 -0.0 2.1
Medication: Lansoprazole 0.2 0.3 0.8 0.3 0.4 0.2 0.9 0.5
Prospective memory result 0.3 0.3 0.8 -0.9 -0.3 -0.8 0.1 -0.2
Lung cancer (father) 0.4 0.5 1.0 -0.5 0.9 -0.5 -0.7 1.0
Illnesses of mother 0.1 0.1 0.3 0.0 -0.6 0.0 0.1 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 3.5 -1.8 1.9 0.6 0.9 1.0
Pulse wave Arterial Stiffness index 1.3 1.5 3.7 -0.4 1.9 1.0 0.7 1.4
Impedance of arm (left) 0.5 2.5 4.2 2.0 -1.6 0.6 -1.3 -1.9
Arm fat mass (right) 0.1 0.6 1.8 -0.5 1.3 -0.1 -0.4 0.8
Trunk predicted mass 0.4 2.1 4.3 -1.1 2.1 0.4 1.4 1.6
Standing height 0.2 2.2 5.3 1.0 1.0 2.3 1.9 -0.1
Length of working week for main job 2.5 2.7 8.1 -1.0 0.3 -2.8 -2.0 -0.7
Exposure to tobacco smoke at home 1.1 1.2 2.2 0.6 -1.5 -1.2 -1.1 -0.9
Breastfed as a baby 0.4 0.4 1.1 1.0 -0.7 -0.4 -0.3 -0.6
Tense / ‘highly strung’ 0.2 0.3 0.4 0.5 -0.6 -0.4 -0.7 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.1 -0.3 -0.4 -0.2 0.2 0.3
Hair/balding pattern: Pattern 4 1.2 2.9 6.3 0.2 -1.4 -1.9 -2.5 -1.7
Birth weight of first child 0.4 0.7 1.1 -0.8 1.1 0.9 1.0 0.4
Peak expiratory flow (PEF) 1.4 3.2 9.6 -3.1 1.9 -0.0 0.7 1.5
Pulse wave reflection index 0.1 0.1 0.3 0.0 -0.0 -0.2 -0.5 -0.4
Ever highly irritable/argumentative for 2 days 1.8 2.2 4.4 -0.2 -1.2 -2.1 -2.1 -0.8
Loud music exposure frequency 0.5 0.6 1.4 0.3 -1.2 -1.0 -0.4 -0.5
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.5 -0.6 -0.7 1.2 0.7 1.1
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 3.6 -0.9 -1.4 -1.9 -1.6 -0.1
Blood clot in the leg (DVT) 1.5 2.0 3.9 1.0 -0.4 -2.0 -1.7 -1.5
Medication: Paracetamol 0.3 0.6 1.2 -0.4 1.1 0.4 0.7 1.0
Headache pain in last month 0.1 0.1 0.4 -0.2 -0.6 0.1 0.1 0.5
Medication for cholesterol, blood pressure or diabetes 2.3 3.9 10.2 -3.2 1.5 -1.4 -0.4 2.2
Glaucoma (self-reported) 0.5 0.5 1.2 0.6 -0.6 -0.3 -1.1 -0.8
Gout (self-reported) 0.5 0.7 1.8 1.4 -0.0 1.2 0.4 0.1
Hypothyroidism/myxoedema (self-reported) 3.0 5.8 12.7 0.9 -1.4 -2.1 -3.0 -3.6
Medication: Amlodipine 0.4 0.5 1.1 1.0 0.3 -0.1 1.0 -0.5
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.2 -1.0 -0.5 -0.1 1.1 0.4
Birth weight 0.1 0.2 0.5 0.7 0.7 -0.2 -0.1 0.3
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.1 -1.0 0.6 -0.3 -1.1 1.0
High blood pressure (siblings) 2.2 3.2 5.8 -1.0 2.4 1.0 2.0 2.1
Forced vital capacity (FVC), Best measure 0.1 0.4 0.6 -0.8 0.7 0.7 0.7 0.0
Body fat percentage 0.1 0.3 0.6 -0.3 0.7 0.7 -0.3 0.5
Leg fat percentage (right) 0.2 0.8 1.1 -1.0 1.0 0.9 0.2 1.0
Arm fat-free mass (right) 0.3 1.4 2.7 -1.3 1.7 -0.1 1.0 1.3
Exposure to tobacco smoke outside home 0.1 0.2 0.6 0.8 -0.2 -0.2 -0.4 -0.3
Comparative body size at age 10 0.6 1.5 5.8 2.4 -1.2 0.5 0.4 -0.3
Number of full brothers 0.9 1.1 2.0 1.0 -0.1 -1.3 -0.8 -1.4
Worry too long after embarrassment 0.9 1.6 4.2 -2.0 -0.6 -1.4 -1.1 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.1 -0.5 0.6 -1.5 -1.1 0.8
Wheeze or whistling in the chest in last year 0.1 0.2 0.5 0.7 0.1 -0.2 0.3 -0.5
Number of children fathered 0.5 0.5 1.5 0.7 1.2 -0.4 -0.2 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 1.6 -0.9 -1.3 -1.1 -1.2 -0.4
Age at first live birth 0.2 0.3 0.9 -0.1 1.0 0.0 0.1 -0.8
Pulse wave peak to peak time 1.4 1.6 4.2 0.8 -2.0 -0.6 -0.6 -1.6
Health satisfaction 1.2 1.5 3.9 -0.3 -0.2 -2.0 -1.6 -1.1
Shortness of breath walking on level ground 1.0 1.2 4.3 -2.1 0.2 -0.7 -0.3 1.0
Qualifications: College or University degree 0.4 1.4 3.0 1.1 0.8 1.7 1.3 -0.2
Eye problems/disorders: None of the above 0.5 0.6 1.5 -0.4 -0.2 0.9 1.2 0.6
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.8 0.9 -0.7 0.9 0.4 -0.6
Emphysema/chronic bronchitis 0.4 0.4 1.3 -0.5 0.6 -0.3 -0.2 1.1
Medication for pain relief, constipation, heartburn 0.1 0.1 0.3 0.0 -0.5 -0.3 -0.1 -0.4
Neck or shoulder pain in last month 0.9 1.2 3.1 1.2 0.1 1.8 1.2 0.5
Medication: Blood pressure 1.5 2.6 6.0 2.4 0.7 2.2 1.1 -0.8
Angina (self-reported) 1.2 1.6 3.8 0.4 1.0 1.9 1.7 0.6
Migraine (self-reported) 1.1 1.4 3.5 -1.9 -0.4 0.4 0.9 1.6
Medication: Ibuprofen 0.1 0.1 0.4 0.3 0.6 -0.2 -0.3 -0.1
Medication: Allopurinol 0.6 0.8 1.4 0.6 1.2 1.2 0.6 0.6
Medication: Omeprazole 0.7 0.9 2.5 -1.0 -1.6 -0.3 -0.7 -0.5
Medication: Seretide 50 evohaler 0.2 0.2 0.5 0.5 -0.1 0.3 0.7 0.3
Mean time to correctly identify matches 1.1 2.2 5.9 -0.7 -0.5 -2.4 -2.0 -0.3
Heart disease (mother) 1.6 2.0 3.5 -0.8 1.8 1.3 0.8 1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 4.5 -2.1 0.7 -0.5 -0.3 1.3
Whole body fat mass 0.1 0.6 1.6 -0.5 1.3 0.5 -0.1 0.8
Leg fat mass (right) 0.2 0.7 1.3 -0.9 1.1 0.6 0.2 1.0
Arm predicted mass (right) 0.3 1.5 3.0 -1.4 1.7 -0.1 1.0 1.2
Pulse rate, automated reading 1.2 3.9 7.8 -1.9 2.6 0.3 1.0 2.8
Alcohol intake frequency. 0.4 1.0 2.3 -1.5 0.3 -1.2 -0.9 0.5
Comparative height size at age 10 0.4 2.5 8.2 2.9 -0.5 1.6 0.8 -0.9
Number of full sisters 0.4 0.5 1.2 -1.1 0.8 0.3 0.4 0.6
Suffer from ‘nerves’ 1.2 1.9 4.0 -2.0 1.3 -0.0 0.3 2.0
Overall health rating 0.2 0.4 1.0 0.3 -0.4 -0.8 -1.0 -0.1
Chest pain or discomfort 1.0 1.5 4.5 1.3 -2.1 0.0 0.1 -1.1
Had major operations 0.2 0.3 1.1 0.0 -0.3 0.3 1.1 -0.0
Age at last live birth 0.5 0.7 1.1 1.0 0.4 1.1 0.6 -0.8
Family relationship satisfaction 0.5 0.7 1.2 1.1 -1.0 0.7 0.3 -0.8
Leg pain on walking 0.6 0.8 2.3 -0.0 -0.5 -1.5 -1.2 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.3 -1.5 0.5 -0.8 -0.3 1.2
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.4 0.2 -0.2 -0.3 0.6 -0.3
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 3.7 1.9 0.1 0.9 -0.1 -0.3
Medication: Aspirin 0.8 1.1 2.6 1.0 0.8 1.6 1.1 0.3
Supplements: Vitamin C 0.1 0.1 0.4 0.1 -0.6 -0.0 -0.3 -0.5
Knee pain experienced in last month 0.3 0.4 1.0 -1.0 -0.3 -0.4 -0.8 0.4
Hypertension (Self-reported) 0.6 1.5 2.7 1.6 0.0 1.6 1.0 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.6 0.6 -0.5 -0.7 -0.5 -0.8
Illnesses of father: Heart disease 1.4 1.9 3.0 -0.5 1.5 1.5 1.7 1.4
Illnesses of siblings: Diabetes 0.4 0.5 1.0 0.5 -1.0 -0.5 0.1 -1.0
Smoking status: Previous 2.5 3.7 5.9 -0.3 2.3 2.4 2.1 1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.3 1.1 0.4 1.1 0.8 -0.7
Whole body fat-free mass 0.4 2.3 5.4 -1.3 2.3 0.1 1.2 1.7
Leg fat-free mass (right) 0.3 1.5 4.3 -1.0 2.1 -0.5 0.6 1.2
Arm fat percentage (left) 0.1 0.5 1.0 -0.4 1.0 -0.5 -0.9 0.5
Average weekly red wine intake 1.5 2.3 3.1 0.5 1.7 1.8 1.7 1.5
Handedness (chirality/laterality): Left-handed 0.8 1.0 3.5 0.6 -0.1 1.9 1.1 -0.2
Mood swings 1.3 2.3 7.3 -2.7 -1.9 -0.4 -0.5 0.3
Loneliness, isolation 0.8 1.1 2.8 -0.3 -0.5 -1.7 -1.2 -1.0
Long-standing illness, disability or infirmity 0.0 0.1 0.2 -0.2 0.1 0.5 0.2 -0.1
Ever had bowel cancer screening 2.3 2.7 5.5 -0.8 2.3 1.1 1.1 2.2
Diabetes diagnosed by doctor 0.7 1.1 4.8 -0.1 2.2 0.4 0.1 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 0.3 -0.5 -0.2 -0.2 0.1
Friendships satisfaction 0.8 1.0 2.0 1.4 -1.4 0.4 0.2 -0.9
Qualifications: nursing, teaching 0.6 0.9 2.0 1.1 -1.1 -0.2 -0.4 -1.4
Commuting to job workplace: Walk 0.0 0.0 0.1 -0.2 -0.2 -0.1 -0.3 -0.1
Eye problems/disorders: Cataract 1.0 1.2 3.7 1.4 -0.6 0.0 -0.3 -1.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 -0.6 0.4 -0.4 -0.4 0.1
Medication for cholesterol 0.2 0.3 0.7 -0.6 -0.6 0.8 0.2 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.6 -0.2 -1.2 0.8 -0.2 -0.9
Back pain experienced in last month 0.9 1.3 3.3 1.8 -0.8 0.6 1.0 -1.1
Mineral and other dietary supplements 1.4 1.8 4.3 -2.1 0.9 -0.3 -0.6 1.9
Breast cancer (self-reported) 0.1 0.1 0.2 0.5 0.3 0.2 0.1 -0.1
Asthma (self-reported) 0.5 1.0 2.0 -1.4 0.3 1.3 0.4 1.1
Osteoporosis (self-reported) 0.4 0.5 1.0 -1.0 0.9 0.7 0.5 -0.1
Osteoarthritis (self-reported) 0.2 0.2 0.6 0.4 -0.4 0.6 0.7 -0.0
Medication: Aspirin 0.6 0.8 1.9 0.8 0.7 1.4 1.0 0.2
Medication: Gliclazide 0.3 0.4 0.8 -0.9 0.8 0.2 0.6 0.3
Illnesses of father: None of the above (group 1) 0.1 0.1 0.4 0.3 -0.2 -0.0 -0.7 -0.1
Smoking status: Current 1.7 2.7 5.2 0.7 -1.5 -2.3 -1.6 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 3.5 -1.9 0.8 -0.0 -0.5 0.7
Whole body water mass 0.4 2.1 5.1 -1.2 2.3 0.1 1.2 1.6
Leg predicted mass (right) 0.3 1.6 4.8 -1.1 2.2 -0.4 0.5 1.3
Arm fat mass (left) 0.1 0.6 2.0 -0.5 1.4 -0.2 -0.4 0.8
Number of self-reported non-cancer illnesses 0.6 1.1 2.4 1.0 -0.2 1.5 1.3 -0.4
Average weekly champagne plus white wine intake 0.1 0.2 0.3 -0.2 -0.5 -0.3 -0.5 -0.3
Miserableness 0.4 0.7 2.8 -0.7 -1.7 0.0 0.3 0.5
Guilty feelings 0.1 0.2 0.6 0.0 -0.8 -0.5 0.0 -0.2
Wears glasses or contact lenses 0.6 0.7 1.5 0.8 -1.2 -0.6 -0.1 -0.9
Ever taken oral contraceptive pill 0.3 0.3 1.1 -1.1 0.1 0.3 0.3 0.5
Hearing aid user 1.4 1.6 3.4 0.5 -1.8 -0.8 -1.1 -1.6
Mother’s age at death 0.2 0.3 0.5 0.4 -0.7 0.1 -0.5 -0.7
Financial situation satisfaction 0.5 0.7 1.1 -0.1 -1.1 -0.9 -0.7 -0.9
Tinnitus: Yes, now most or all of the time 1.5 1.8 4.9 1.0 0.5 2.2 1.3 1.0
Commuting to job workplace: Public transport 0.3 0.4 1.3 -0.1 1.1 0.1 0.6 0.3
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 -0.2 -0.7 -0.2 -0.5 0.1
Medication: Blood pressure 0.2 0.5 1.0 0.1 0.3 -1.0 -0.5 -1.0
Pain type(s) experienced in last month: Hip pain 1.2 1.5 3.1 0.5 -1.8 -1.0 -1.3 -1.1
Supplements: Fish oil (including cod liver oil) 1.8 2.3 4.8 2.0 -1.4 0.4 0.6 -2.2
High cholesterol (Self-reported) 0.5 0.9 2.1 1.3 -0.6 -0.3 -0.6 -1.4
Medication: Bendroflumethiazide 0.9 1.3 4.2 -0.9 2.0 0.5 0.6 1.1
Medication: Paracetamol 0.3 0.5 1.4 -0.2 1.2 0.3 0.6 0.8
Medication: Lisinopril 0.3 0.4 1.2 0.8 1.1 0.2 -0.1 -0.1
Medication: Atorvastatin 0.2 0.3 0.5 -0.2 0.2 0.7 0.5 0.7
Illnesses of father: High blood pressure 1.2 1.5 2.2 -0.9 1.1 1.1 1.4 1.5
Alcohol drinker status: Never 0.6 0.7 1.3 -0.7 -0.5 -1.1 -1.1 -0.4
Ever smoked 0.6 1.1 2.2 1.5 0.8 0.8 1.3 0.5
Basal metabolic rate 0.4 2.0 5.1 -1.3 2.3 0.1 1.0 1.6
Leg fat percentage (left) 0.2 0.6 0.9 -0.9 0.8 0.7 0.3 0.9
Arm fat-free mass (left) 0.3 1.4 3.5 -1.1 1.9 0.1 1.0 1.2
Number of operations (self-reported) 0.5 0.7 1.6 1.3 -0.4 0.3 0.9 -0.9
Average weekly beer plus cider intake 0.3 0.5 1.1 -0.1 -0.9 0.3 1.1 0.5
Irritability 0.4 0.7 1.5 0.8 -1.2 -0.3 0.2 -1.2
Risk taking 0.8 1.2 2.7 -0.0 1.1 1.0 1.7 1.1
Ever had prostate specific antigen (PSA) test 1.6 1.9 3.1 0.6 1.4 1.7 1.8 1.1
Fractured/broken bones in last 5 years 3.7 4.8 10.3 3.2 -0.8 2.5 2.0 -1.8
Age started oral contraceptive pill 1.2 1.4 4.7 -0.5 2.2 -0.7 -1.1 0.7
Diastolic blood pressure, automated reading 0.0 0.0 0.1 0.2 -0.2 0.1 0.2 -0.3
Ever depressed for a whole week 0.3 0.4 1.2 -0.4 -0.5 -1.1 -0.1 -0.5
Unable to work because of sickness or disability 0.2 0.2 0.6 0.6 -0.4 0.8 0.4 -0.2
Commuting to job workplace: Cycle 2.3 2.8 7.5 -0.5 2.7 1.1 1.0 2.0
Myopia 1.2 1.8 2.9 -0.5 1.4 1.5 1.7 1.2
Vascular/heart problems diagnosed by doctor 0.8 2.2 4.9 -2.2 0.7 -1.5 -1.0 1.5
Cholesterol lowering medication 1.5 2.2 5.2 -1.3 2.3 0.1 1.3 1.6
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.6 -1.3 -1.2 -0.6 -0.8 -0.6
Pain experienced in last month 0.2 0.4 1.6 0.1 1.3 0.2 0.3 -0.1
Supplements: Calcium 1.1 1.2 3.9 -0.6 2.0 0.9 0.3 1.0
Basal cell carcinoma (self-reported) 1.3 1.6 4.9 2.2 0.9 0.9 0.7 -1.0
Heart attack/myocardial infarction (self-reported) 4.7 6.0 7.9 2.1 -2.5 -2.4 -2.3 -2.8
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 4.0 0.8 -0.3 -2.0 -1.8 -1.5
Heart disease (siblings) 0.0 0.0 0.1 0.1 0.2 -0.0 0.1 -0.0
Alcohol drinker status: Previous 0.8 0.9 2.1 -1.5 -0.4 -1.2 -0.8 0.4
Pack years of smoking 0.1 0.1 0.3 -0.5 -0.1 -0.2 0.2 0.5
Impedance of whole body 0.7 3.7 6.3 2.2 -2.5 1.4 -0.8 -2.2
Leg fat mass (left) 0.2 0.7 1.4 -0.9 1.2 0.6 0.2 0.9
Arm predicted mass (left) 0.3 1.3 3.2 -1.0 1.8 0.2 1.1 1.2