Hub : Genes

TYSND1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.3210	0.0770	1.7e-04	0.190	NA	0.130	NA	0.175	7.6e-09	NA	2.2e-06	NA	3.4e-08
2	NTR	Blood	0.0436	0.0119	6.4e-06	0.019	0.017	0.013	0.017	0.014	7.8e-07	3.2e-06	3.7e-05	1.9e-06	1.4e-05
3	ROSMAP	Brain Pre-frontal Cortex	0.1546	0.0336	8.5e-09	0.081	0.080	0.100	0.115	0.111	1.2e-10	1.8e-10	9.2e-13	1.5e-14	3.7e-14
4	YFS	Blood	0.2006	0.0297	0.0e+00	0.061	0.106	0.126	0.130	0.113	3.8e-19	6.6e-33	4.2e-39	3.4e-40	6.1e-35
5	TCGA	Brain Lower Grade Glioma	0.0348	0.0151	1.2e-03	0.039	0.027	0.035	NA	0.035	2.9e-05	4.6e-04	6.5e-05	NA	6.8e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.2	1.9	2.9	0.2	1.3	1.5	1.6	1.7
Bipolar Disorder or Schizophrenia	0.3	0.8	1.5	0.8	-0.5	-1.2	-1.0	-0.7
Depressed Affect (Nagel 2018)	1.2	2.5	7.0	-0.9	-2.6	-1.4	-1.5	-0.6
Depression (Nagel 2018)	0.3	0.4	1.3	0.8	-1.1	-0.1	-0.3	0.4
Intelligence (Savage-Jansen 2018)	1.1	3.5	11.7	3.4	-0.9	0.0	-0.5	-2.2
Neuroticism (Nagel 2018)	0.4	0.9	2.2	-0.7	-1.5	-1.0	-0.9	-0.3
Schizophrenia (2018)	2.4	4.9	8.2	0.9	-1.8	-2.9	-2.6	-2.3
Schizophrenia vs Biploar Disorder	1.6	2.1	4.6	-1.1	-0.7	-2.0	-2.1	-0.4
Worry (Nagel 2018)	0.1	0.2	0.3	-0.5	-0.1	-0.5	-0.5	0.2
Alzheimer’s Disease (in mother)	1.5	1.8	3.0	-0.3	-1.7	-1.6	-1.1	-1.5
Alzheimer’s Disease (in father)	3.8	4.2	7.9	2.8	-2.8	0.0	-0.1	-2.2
Alzheimer’s Disease (including proxy)	2.7	4.0	10.1	0.7	-3.2	-1.3	-0.9	-2.6
Crohns Disease (2017)	0.6	1.2	1.9	-1.0	0.5	1.2	1.4	1.3
Irritable Bowel Disease (IBD)	0.5	1.1	2.6	-1.4	0.6	0.2	0.7	1.6
Ulcerative Colitis (UC)	0.3	0.6	1.5	-1.0	0.5	-0.6	0.0	1.2
Major Depression (MDD)	3.5	4.3	11.7	3.4	-1.6	0.5	0.1	-2.6
Reaction Time	1.0	1.8	4.9	0.1	-0.4	-2.2	-1.9	-0.8
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.5	2.1	-0.2	0.7	0.4	-1.3
Breast Cancer	1.3	3.0	7.0	-0.7	2.6	1.9	1.2	1.6
Ovarian Cancer	1.1	1.5	2.1	1.4	-1.1	-1.0	-1.0	-1.4
Prostate Cancer	0.4	0.6	1.8	-0.2	1.4	-0.5	-0.9	0.5
Age at First Birth	0.3	0.4	1.2	-1.1	0.4	-0.7	-0.1	-0.3
Bipolar Disorder (2011)	0.5	0.5	1.5	-0.5	-0.1	-1.2	-0.3	0.9
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	-0.9	-0.4	-0.7	-0.4	-0.2
Coronary Artery Disease (CAD)	0.3	0.3	0.9	-0.3	-0.7	-0.9	0.0	-0.3
Crohns Disease (2012)	0.1	0.1	0.2	-0.3	0.3	-0.1	-0.2	0.4
Mean Putamen Volume	1.6	1.9	2.8	1.4	-1.2	-1.1	-1.3	-1.7
Fasting Glucose	0.3	0.3	1.4	0.3	1.2	-0.1	-0.4	0.2
HbA1C	1.2	1.4	2.5	1.3	0.5	1.6	1.4	0.6
HDL Cholesterol	1.5	2.5	5.2	1.8	-2.0	0.0	-0.4	-2.3
LDL Cholesterol	2.2	3.5	8.5	-1.3	-0.6	-2.9	-2.2	-1.4
Lupus	3.5	5.3	7.7	0.1	2.7	2.5	2.8	2.2
Neuroticism (2016)	0.4	0.5	0.9	-1.0	-0.6	-0.9	-0.5	-0.4
Primary Biliary Cirrhosis	0.3	0.4	0.6	0.8	-0.2	-0.7	-0.5	-0.6
Rheumatoid Arthritis	1.0	1.4	4.0	2.0	-1.1	0.3	0.4	-1.3
Schizophrenia (2014)	1.9	4.2	7.6	0.7	-1.5	-2.7	-2.8	-1.8
Triglycerides	1.0	1.6	4.1	-0.4	2.0	0.9	0.8	1.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.0	0.3	0.5	-1.0	-0.7	0.4
Ulcerative Colitis	0.1	0.2	0.6	-0.3	-0.4	-0.8	-0.4	0.1
Blood Eosinophil Count	0.3	2.3	5.2	-0.1	1.6	-2.3	-1.7	-0.9
Blood Platelet Count	0.0	0.3	0.6	0.7	0.6	-0.4	0.2	-0.5
Blood Red Count	1.5	14.2	27.6	2.1	-4.2	-3.1	-3.4	-5.2
Blood White Count	0.2	1.6	3.0	0.4	1.2	-1.6	-1.7	-0.8
Heel T-Score	0.3	2.7	5.0	-1.4	1.5	1.2	1.8	2.2
BMI	0.1	0.6	1.3	-0.5	0.9	0.4	0.6	1.1
Height	0.1	2.4	5.7	-0.2	1.9	2.4	1.3	1.2
Waist Hip Ratio (WHR)	0.1	0.2	1.0	1.0	0.3	0.1	-0.3	0.1
Systolic Blood Pressure	0.3	1.5	3.0	1.4	-1.3	0.7	0.5	-1.7
Smoking Status	0.1	0.3	0.7	0.1	0.9	-0.6	0.0	0.5
Allergy or Eczema	0.7	1.9	5.1	-2.3	1.4	-0.0	0.6	1.4
Cardiovascular Disease	0.6	2.1	4.3	2.1	0.3	1.5	1.4	-1.3
Hypothyroidism (self reported)	1.6	3.8	10.3	0.6	-1.7	-1.2	-2.0	-3.2
Respiratory disease	0.3	0.6	0.9	-0.8	0.8	1.0	0.3	0.9
Type 2 Diabetes (T2D) (2018)	0.9	1.8	6.6	-0.1	2.6	0.8	0.8	1.0
Lung FEV1/FVC ratio	1.6	8.4	18.9	-2.5	4.3	0.9	2.4	3.2
Lung FVC	0.1	0.7	1.4	-0.7	0.2	-1.2	-1.1	-0.6
Neuroticism	0.7	1.7	2.5	-1.4	-1.6	-1.4	-1.3	-0.1
Chronotype (morning person)	0.4	0.8	1.3	-1.1	-0.0	-0.7	-1.1	-1.1
Hair Pigment	0.1	2.7	5.5	-1.4	-0.9	-2.1	-2.4	-0.9
Tanning	0.1	1.1	1.7	1.2	1.0	1.3	1.2	0.2
Hand grip strength (left)	0.3	0.7	2.4	0.3	0.4	0.9	1.6	-0.5
Number of treatments/medications taken	0.9	1.7	3.7	1.9	0.6	1.3	1.5	-0.6
Average weekly spirits intake	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.1	-0.2
Sensitivity / hurt feelings	0.5	0.9	2.1	-1.4	-1.5	-0.6	-0.4	-0.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.6	-0.2	-1.6	-0.1	-0.3	0.6
Hearing difficulty/problems: Yes	2.7	4.1	5.6	2.4	-2.2	-1.3	-1.8	-2.2
Relative age of first facial hair	0.1	0.2	0.6	0.0	-0.5	0.4	-0.0	-0.8
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.2	1.5	-0.5	1.3	0.5	-0.6
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.8	0.4	0.7	0.5	0.3	1.7
Ever had hysterectomy (womb removed)	0.5	0.6	0.8	0.4	-0.8	-0.9	-0.7	-0.9
Systolic blood pressure, automated reading	0.1	0.4	0.7	0.4	-0.8	-0.1	-0.7	-0.8
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.4	-0.4	0.8	-1.5	-1.5	-0.5
Angina	1.1	1.4	2.9	0.4	1.1	1.7	1.5	0.7
Medication for hormone replacement therapy	0.5	0.6	1.7	1.3	0.5	0.5	0.1	0.9
Vitamin and mineral supplements	0.4	0.6	1.4	-0.7	0.5	-1.2	-0.5	0.8
Supplements: Zinc	0.6	0.6	2.3	0.7	1.5	-0.3	-0.5	-0.3
Medication: Co-codamol	0.3	0.4	0.6	-0.7	0.6	-0.8	-0.4	-0.5
Medication: Metformin	0.8	1.2	4.1	-0.7	2.0	0.2	0.6	0.9
Diabetes (father)	1.1	1.3	2.5	-1.6	0.7	1.1	1.2	1.0
Diabetes (mother)	2.1	2.7	7.6	-0.3	-0.6	-1.9	-2.8	-1.4
Severe depression (siblings)	1.3	1.4	4.2	-2.0	0.3	-0.5	0.6	1.5
Pack years adult smoking proportion	0.1	0.2	0.6	-0.8	-0.2	-0.4	0.0	0.4
Impedance of leg (right)	0.5	2.3	4.8	0.9	-2.0	2.2	-0.0	-1.3
Leg fat-free mass (left)	0.3	1.7	4.9	-1.2	2.2	-0.2	0.5	1.3
Trunk fat percentage	0.0	0.2	0.7	-0.0	0.3	0.4	-0.8	-0.0
Hand grip strength (right)	0.3	0.8	3.1	0.6	-0.4	-0.3	-0.1	-1.8
Townsend deprivation index at recruitment	0.8	1.1	1.8	1.3	-0.3	-1.3	-0.9	-1.1
Current tobacco smoking	2.1	3.4	5.8	0.7	-1.9	-2.4	-1.8	-1.9
Average weekly fortified wine intake	0.3	0.4	1.2	0.7	-0.2	0.0	0.1	-1.1
Maternal smoking around birth	0.8	1.2	2.8	-1.0	-0.5	-1.7	-1.2	-0.6
Fed-up feelings	0.7	1.3	4.5	-0.7	-2.1	-0.5	-0.8	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	-0.0	-0.8	-0.3	-0.6	0.6
Relative age voice broke	0.7	1.1	2.7	-1.6	1.3	-0.6	-0.8	0.5
Taking other prescription medications	0.5	0.7	1.2	-0.6	1.1	1.0	0.7	0.7
Age when periods started (menarche)	0.1	0.1	0.4	0.6	-0.0	-0.4	0.1	-0.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	4.2	2.1	-0.7	0.4	0.4	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.9	-0.4	-0.1	-0.2	0.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	3.4	1.9	-0.4	1.3	1.0	0.1
Qualifications: CSEs or equivalent	0.8	1.1	1.9	-1.0	-0.2	1.1	1.2	1.4
Serious illness, injury or assault to yourself	0.3	0.3	0.5	0.6	0.6	0.6	0.7	0.3
High blood pressure	0.5	1.5	2.6	1.6	-0.3	1.6	0.9	-1.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	-1.3	0.8	0.5	1.0	0.5
Multivitamins +/- minerals	0.5	0.6	1.0	0.9	-0.7	0.7	0.6	-1.0
Stomach or abdominal pain in last month	1.7	2.1	5.0	-2.2	-1.4	-1.2	-1.3	-0.7
Supplements: Glucosamine	1.2	1.6	3.5	1.5	-0.9	-1.2	-0.2	-1.9
Diverticular disease/diverticulitis (self-reported)	2.4	2.8	4.5	-2.0	2.1	0.6	1.0	2.0
Medication: Atenolol	0.3	0.4	1.1	0.4	-0.3	-0.4	-0.5	-1.1
Medication: Levothyroxine sodium	3.5	5.9	12.2	0.0	-0.9	-2.8	-3.5	-2.9
Sitting height	0.4	2.6	5.8	0.1	2.4	1.7	1.8	0.9
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-0.1	-0.7	-1.1	-0.1	-1.2
High blood pressure (mother)	0.4	0.5	1.0	-0.4	1.0	0.9	0.7	0.5
Body mass index (BMI)	0.3	1.1	2.0	-1.3	1.4	-0.5	-0.3	1.2
Impedance of leg (left)	0.5	2.6	5.3	1.2	-2.3	1.9	0.0	-1.6
Leg predicted mass (left)	0.3	1.6	4.8	-1.1	2.2	-0.2	0.5	1.3
Trunk fat mass	0.1	0.4	1.0	-0.5	1.0	0.7	-0.1	0.6
Waist circumference	0.2	0.6	1.3	-0.9	0.9	0.2	0.0	1.1
Number of incorrect matches in round	0.7	1.1	2.9	-1.7	0.7	-0.1	0.1	1.4
Past tobacco smoking	0.9	1.6	3.2	-0.4	-1.8	-1.3	-1.4	-1.1
Alcohol usually taken with meals	0.8	1.4	4.7	0.1	2.2	-0.6	-1.2	0.6
Nervous feelings	0.5	0.9	2.4	-1.5	0.4	-1.0	-0.5	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.0	-1.4	-0.5	-0.9	-0.9	0.9
Hearing difficulty/problems with background noise	1.5	2.5	4.6	2.1	-1.9	-0.7	-1.2	-1.6
Hair/balding pattern: Pattern 2	0.7	0.9	3.8	-1.9	-0.1	0.1	0.6	0.4
Had menopause	1.3	1.6	3.5	0.7	-0.7	-1.8	-1.9	-0.9
Had other major operations	0.9	1.1	3.2	1.8	0.2	0.4	0.8	-1.3
Forced vital capacity (FVC)	0.1	0.4	1.2	-1.1	0.8	0.2	0.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.1	1.1	-0.2	0.1	-0.0	0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.0	0.8	-1.4	-0.8	-0.5	-1.3
Qualifications: None of the above	0.1	0.2	0.4	-0.1	0.2	0.4	0.7	0.5
Financial difficulties in last 2 years	0.1	0.2	0.3	-0.2	-0.6	-0.4	0.2	-0.5
Mouth/teeth dental problems	1.7	2.6	6.2	0.7	1.3	1.9	2.5	0.9
Heart attack	3.8	4.8	5.6	1.7	-2.3	-2.3	-2.2	-2.4
Allergy	0.5	1.2	3.8	2.0	-0.7	-0.5	-0.6	-1.1
Pain all over the body in last month	0.2	0.2	0.4	0.3	-0.6	-0.6	-0.4	-0.3
Diabetes (self-reported)	0.8	1.3	5.7	-0.1	2.4	-0.0	0.0	0.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	4.2	-2.0	0.3	-0.1	0.5	1.3
Medication: Ramipril	1.1	1.4	3.2	1.8	-1.0	0.2	-0.5	-1.7
Medication: Simvastatin	0.4	0.5	1.2	1.1	-0.5	-0.0	0.6	-0.9
Fluid intelligence score	0.9	1.9	4.7	2.2	-0.8	0.7	-0.2	-1.9
Illnesses of siblings	0.7	1.0	2.3	0.1	-1.1	-0.7	-1.5	-1.0
Neuroticism score	0.8	1.6	3.5	-1.9	-1.3	-1.4	-0.8	0.1
Weight	0.3	1.3	3.7	-1.0	1.9	0.6	0.6	1.2
Impedance of arm (right)	0.5	2.5	5.1	2.3	-1.4	1.2	-0.9	-1.7
Arm fat percentage (right)	0.1	0.5	1.2	-0.4	1.1	-0.2	-0.9	0.7
Trunk fat-free mass	0.4	2.4	5.1	-1.2	2.3	0.4	1.5	1.8
Hip circumference	0.1	0.2	0.4	-0.5	0.4	0.5	0.2	0.7
Time employed in main current job	0.3	0.3	1.2	-0.2	1.1	-0.1	0.3	0.6
Alcohol intake versus 10 years previously	1.1	1.6	3.2	1.0	-0.8	-1.5	-1.8	-0.9
Father’s age at death	1.0	1.3	2.1	-0.8	1.5	0.3	1.3	1.5
Worrier / anxious feelings	0.2	0.4	1.7	-1.3	0.2	0.1	-0.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	6.3	-0.0	-2.5	-0.8	-1.1	-0.9
Falls in the last year	0.6	0.8	1.6	-0.7	-0.5	-1.3	-0.7	-1.1
Hair/balding pattern: Pattern 3	0.4	0.5	1.1	1.1	-0.4	-0.8	-0.1	-0.9
Number of live births	0.6	0.9	3.1	1.8	-0.5	-0.4	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.4	-2.2	2.3	0.1	0.6	1.2
Pulse rate	1.1	1.9	4.0	-1.2	1.8	0.2	0.9	2.0
Happiness	0.3	0.3	0.9	0.4	-0.6	-0.3	-0.1	-1.0
Noisy workplace	0.4	0.5	1.3	-0.7	-0.3	-1.1	-0.3	0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.0	-0.5	-0.4	2.0	1.2	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.2	-0.9	0.0	0.8	1.1	0.4
Mouth/teeth dental problems: Dentures	1.0	1.7	4.3	-1.4	-0.2	-1.5	-2.1	-0.1
Asthma	0.5	0.9	1.8	-1.3	0.3	1.3	0.5	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	0.3	0.3	-0.5	-0.6	0.1
Medication: Cholesterol lowering	2.9	4.6	9.6	3.1	-2.5	0.3	-0.1	-2.6
Depression (self-reported)	1.4	1.7	4.4	-1.8	0.8	-0.4	-0.0	2.1
Medication: Lansoprazole	0.2	0.3	0.8	0.3	0.4	0.2	0.9	0.5
Prospective memory result	0.3	0.3	0.8	-0.9	-0.3	-0.8	0.1	-0.2
Lung cancer (father)	0.4	0.5	1.0	-0.5	0.9	-0.5	-0.7	1.0
Illnesses of mother	0.1	0.1	0.3	0.0	-0.6	0.0	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.5	-1.8	1.9	0.6	0.9	1.0
Pulse wave Arterial Stiffness index	1.3	1.5	3.7	-0.4	1.9	1.0	0.7	1.4
Impedance of arm (left)	0.5	2.5	4.2	2.0	-1.6	0.6	-1.3	-1.9
Arm fat mass (right)	0.1	0.6	1.8	-0.5	1.3	-0.1	-0.4	0.8
Trunk predicted mass	0.4	2.1	4.3	-1.1	2.1	0.4	1.4	1.6
Standing height	0.2	2.2	5.3	1.0	1.0	2.3	1.9	-0.1
Length of working week for main job	2.5	2.7	8.1	-1.0	0.3	-2.8	-2.0	-0.7
Exposure to tobacco smoke at home	1.1	1.2	2.2	0.6	-1.5	-1.2	-1.1	-0.9
Breastfed as a baby	0.4	0.4	1.1	1.0	-0.7	-0.4	-0.3	-0.6
Tense / ‘highly strung’	0.2	0.3	0.4	0.5	-0.6	-0.4	-0.7	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.3	-0.4	-0.2	0.2	0.3
Hair/balding pattern: Pattern 4	1.2	2.9	6.3	0.2	-1.4	-1.9	-2.5	-1.7
Birth weight of first child	0.4	0.7	1.1	-0.8	1.1	0.9	1.0	0.4
Peak expiratory flow (PEF)	1.4	3.2	9.6	-3.1	1.9	-0.0	0.7	1.5
Pulse wave reflection index	0.1	0.1	0.3	0.0	-0.0	-0.2	-0.5	-0.4
Ever highly irritable/argumentative for 2 days	1.8	2.2	4.4	-0.2	-1.2	-2.1	-2.1	-0.8
Loud music exposure frequency	0.5	0.6	1.4	0.3	-1.2	-1.0	-0.4	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.5	-0.6	-0.7	1.2	0.7	1.1
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.6	-0.9	-1.4	-1.9	-1.6	-0.1
Blood clot in the leg (DVT)	1.5	2.0	3.9	1.0	-0.4	-2.0	-1.7	-1.5
Medication: Paracetamol	0.3	0.6	1.2	-0.4	1.1	0.4	0.7	1.0
Headache pain in last month	0.1	0.1	0.4	-0.2	-0.6	0.1	0.1	0.5
Medication for cholesterol, blood pressure or diabetes	2.3	3.9	10.2	-3.2	1.5	-1.4	-0.4	2.2
Glaucoma (self-reported)	0.5	0.5	1.2	0.6	-0.6	-0.3	-1.1	-0.8
Gout (self-reported)	0.5	0.7	1.8	1.4	-0.0	1.2	0.4	0.1
Hypothyroidism/myxoedema (self-reported)	3.0	5.8	12.7	0.9	-1.4	-2.1	-3.0	-3.6
Medication: Amlodipine	0.4	0.5	1.1	1.0	0.3	-0.1	1.0	-0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	-1.0	-0.5	-0.1	1.1	0.4
Birth weight	0.1	0.2	0.5	0.7	0.7	-0.2	-0.1	0.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.1	-1.0	0.6	-0.3	-1.1	1.0
High blood pressure (siblings)	2.2	3.2	5.8	-1.0	2.4	1.0	2.0	2.1
Forced vital capacity (FVC), Best measure	0.1	0.4	0.6	-0.8	0.7	0.7	0.7	0.0
Body fat percentage	0.1	0.3	0.6	-0.3	0.7	0.7	-0.3	0.5
Leg fat percentage (right)	0.2	0.8	1.1	-1.0	1.0	0.9	0.2	1.0
Arm fat-free mass (right)	0.3	1.4	2.7	-1.3	1.7	-0.1	1.0	1.3
Exposure to tobacco smoke outside home	0.1	0.2	0.6	0.8	-0.2	-0.2	-0.4	-0.3
Comparative body size at age 10	0.6	1.5	5.8	2.4	-1.2	0.5	0.4	-0.3
Number of full brothers	0.9	1.1	2.0	1.0	-0.1	-1.3	-0.8	-1.4
Worry too long after embarrassment	0.9	1.6	4.2	-2.0	-0.6	-1.4	-1.1	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.1	-0.5	0.6	-1.5	-1.1	0.8
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.7	0.1	-0.2	0.3	-0.5
Number of children fathered	0.5	0.5	1.5	0.7	1.2	-0.4	-0.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	1.6	-0.9	-1.3	-1.1	-1.2	-0.4
Age at first live birth	0.2	0.3	0.9	-0.1	1.0	0.0	0.1	-0.8
Pulse wave peak to peak time	1.4	1.6	4.2	0.8	-2.0	-0.6	-0.6	-1.6
Health satisfaction	1.2	1.5	3.9	-0.3	-0.2	-2.0	-1.6	-1.1
Shortness of breath walking on level ground	1.0	1.2	4.3	-2.1	0.2	-0.7	-0.3	1.0
Qualifications: College or University degree	0.4	1.4	3.0	1.1	0.8	1.7	1.3	-0.2
Eye problems/disorders: None of the above	0.5	0.6	1.5	-0.4	-0.2	0.9	1.2	0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.8	0.9	-0.7	0.9	0.4	-0.6
Emphysema/chronic bronchitis	0.4	0.4	1.3	-0.5	0.6	-0.3	-0.2	1.1
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	0.0	-0.5	-0.3	-0.1	-0.4
Neck or shoulder pain in last month	0.9	1.2	3.1	1.2	0.1	1.8	1.2	0.5
Medication: Blood pressure	1.5	2.6	6.0	2.4	0.7	2.2	1.1	-0.8
Angina (self-reported)	1.2	1.6	3.8	0.4	1.0	1.9	1.7	0.6
Migraine (self-reported)	1.1	1.4	3.5	-1.9	-0.4	0.4	0.9	1.6
Medication: Ibuprofen	0.1	0.1	0.4	0.3	0.6	-0.2	-0.3	-0.1
Medication: Allopurinol	0.6	0.8	1.4	0.6	1.2	1.2	0.6	0.6
Medication: Omeprazole	0.7	0.9	2.5	-1.0	-1.6	-0.3	-0.7	-0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.5	0.5	-0.1	0.3	0.7	0.3
Mean time to correctly identify matches	1.1	2.2	5.9	-0.7	-0.5	-2.4	-2.0	-0.3
Heart disease (mother)	1.6	2.0	3.5	-0.8	1.8	1.3	0.8	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.5	-2.1	0.7	-0.5	-0.3	1.3
Whole body fat mass	0.1	0.6	1.6	-0.5	1.3	0.5	-0.1	0.8
Leg fat mass (right)	0.2	0.7	1.3	-0.9	1.1	0.6	0.2	1.0
Arm predicted mass (right)	0.3	1.5	3.0	-1.4	1.7	-0.1	1.0	1.2
Pulse rate, automated reading	1.2	3.9	7.8	-1.9	2.6	0.3	1.0	2.8
Alcohol intake frequency.	0.4	1.0	2.3	-1.5	0.3	-1.2	-0.9	0.5
Comparative height size at age 10	0.4	2.5	8.2	2.9	-0.5	1.6	0.8	-0.9
Number of full sisters	0.4	0.5	1.2	-1.1	0.8	0.3	0.4	0.6
Suffer from ‘nerves’	1.2	1.9	4.0	-2.0	1.3	-0.0	0.3	2.0
Overall health rating	0.2	0.4	1.0	0.3	-0.4	-0.8	-1.0	-0.1
Chest pain or discomfort	1.0	1.5	4.5	1.3	-2.1	0.0	0.1	-1.1
Had major operations	0.2	0.3	1.1	0.0	-0.3	0.3	1.1	-0.0
Age at last live birth	0.5	0.7	1.1	1.0	0.4	1.1	0.6	-0.8
Family relationship satisfaction	0.5	0.7	1.2	1.1	-1.0	0.7	0.3	-0.8
Leg pain on walking	0.6	0.8	2.3	-0.0	-0.5	-1.5	-1.2	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.3	-1.5	0.5	-0.8	-0.3	1.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.2	-0.2	-0.3	0.6	-0.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.7	1.9	0.1	0.9	-0.1	-0.3
Medication: Aspirin	0.8	1.1	2.6	1.0	0.8	1.6	1.1	0.3
Supplements: Vitamin C	0.1	0.1	0.4	0.1	-0.6	-0.0	-0.3	-0.5
Knee pain experienced in last month	0.3	0.4	1.0	-1.0	-0.3	-0.4	-0.8	0.4
Hypertension (Self-reported)	0.6	1.5	2.7	1.6	0.0	1.6	1.0	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.6	0.6	-0.5	-0.7	-0.5	-0.8
Illnesses of father: Heart disease	1.4	1.9	3.0	-0.5	1.5	1.5	1.7	1.4
Illnesses of siblings: Diabetes	0.4	0.5	1.0	0.5	-1.0	-0.5	0.1	-1.0
Smoking status: Previous	2.5	3.7	5.9	-0.3	2.3	2.4	2.1	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.3	1.1	0.4	1.1	0.8	-0.7
Whole body fat-free mass	0.4	2.3	5.4	-1.3	2.3	0.1	1.2	1.7
Leg fat-free mass (right)	0.3	1.5	4.3	-1.0	2.1	-0.5	0.6	1.2
Arm fat percentage (left)	0.1	0.5	1.0	-0.4	1.0	-0.5	-0.9	0.5
Average weekly red wine intake	1.5	2.3	3.1	0.5	1.7	1.8	1.7	1.5
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.5	0.6	-0.1	1.9	1.1	-0.2
Mood swings	1.3	2.3	7.3	-2.7	-1.9	-0.4	-0.5	0.3
Loneliness, isolation	0.8	1.1	2.8	-0.3	-0.5	-1.7	-1.2	-1.0
Long-standing illness, disability or infirmity	0.0	0.1	0.2	-0.2	0.1	0.5	0.2	-0.1
Ever had bowel cancer screening	2.3	2.7	5.5	-0.8	2.3	1.1	1.1	2.2
Diabetes diagnosed by doctor	0.7	1.1	4.8	-0.1	2.2	0.4	0.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.3	-0.5	-0.2	-0.2	0.1
Friendships satisfaction	0.8	1.0	2.0	1.4	-1.4	0.4	0.2	-0.9
Qualifications: nursing, teaching	0.6	0.9	2.0	1.1	-1.1	-0.2	-0.4	-1.4
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.3	-0.1
Eye problems/disorders: Cataract	1.0	1.2	3.7	1.4	-0.6	0.0	-0.3	-1.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	-0.6	0.4	-0.4	-0.4	0.1
Medication for cholesterol	0.2	0.3	0.7	-0.6	-0.6	0.8	0.2	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.6	-0.2	-1.2	0.8	-0.2	-0.9
Back pain experienced in last month	0.9	1.3	3.3	1.8	-0.8	0.6	1.0	-1.1
Mineral and other dietary supplements	1.4	1.8	4.3	-2.1	0.9	-0.3	-0.6	1.9
Breast cancer (self-reported)	0.1	0.1	0.2	0.5	0.3	0.2	0.1	-0.1
Asthma (self-reported)	0.5	1.0	2.0	-1.4	0.3	1.3	0.4	1.1
Osteoporosis (self-reported)	0.4	0.5	1.0	-1.0	0.9	0.7	0.5	-0.1
Osteoarthritis (self-reported)	0.2	0.2	0.6	0.4	-0.4	0.6	0.7	-0.0
Medication: Aspirin	0.6	0.8	1.9	0.8	0.7	1.4	1.0	0.2
Medication: Gliclazide	0.3	0.4	0.8	-0.9	0.8	0.2	0.6	0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	0.3	-0.2	-0.0	-0.7	-0.1
Smoking status: Current	1.7	2.7	5.2	0.7	-1.5	-2.3	-1.6	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.5	-1.9	0.8	-0.0	-0.5	0.7
Whole body water mass	0.4	2.1	5.1	-1.2	2.3	0.1	1.2	1.6
Leg predicted mass (right)	0.3	1.6	4.8	-1.1	2.2	-0.4	0.5	1.3
Arm fat mass (left)	0.1	0.6	2.0	-0.5	1.4	-0.2	-0.4	0.8
Number of self-reported non-cancer illnesses	0.6	1.1	2.4	1.0	-0.2	1.5	1.3	-0.4
Average weekly champagne plus white wine intake	0.1	0.2	0.3	-0.2	-0.5	-0.3	-0.5	-0.3
Miserableness	0.4	0.7	2.8	-0.7	-1.7	0.0	0.3	0.5
Guilty feelings	0.1	0.2	0.6	0.0	-0.8	-0.5	0.0	-0.2
Wears glasses or contact lenses	0.6	0.7	1.5	0.8	-1.2	-0.6	-0.1	-0.9
Ever taken oral contraceptive pill	0.3	0.3	1.1	-1.1	0.1	0.3	0.3	0.5
Hearing aid user	1.4	1.6	3.4	0.5	-1.8	-0.8	-1.1	-1.6
Mother’s age at death	0.2	0.3	0.5	0.4	-0.7	0.1	-0.5	-0.7
Financial situation satisfaction	0.5	0.7	1.1	-0.1	-1.1	-0.9	-0.7	-0.9
Tinnitus: Yes, now most or all of the time	1.5	1.8	4.9	1.0	0.5	2.2	1.3	1.0
Commuting to job workplace: Public transport	0.3	0.4	1.3	-0.1	1.1	0.1	0.6	0.3
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	-0.2	-0.7	-0.2	-0.5	0.1
Medication: Blood pressure	0.2	0.5	1.0	0.1	0.3	-1.0	-0.5	-1.0
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.1	0.5	-1.8	-1.0	-1.3	-1.1
Supplements: Fish oil (including cod liver oil)	1.8	2.3	4.8	2.0	-1.4	0.4	0.6	-2.2
High cholesterol (Self-reported)	0.5	0.9	2.1	1.3	-0.6	-0.3	-0.6	-1.4
Medication: Bendroflumethiazide	0.9	1.3	4.2	-0.9	2.0	0.5	0.6	1.1
Medication: Paracetamol	0.3	0.5	1.4	-0.2	1.2	0.3	0.6	0.8
Medication: Lisinopril	0.3	0.4	1.2	0.8	1.1	0.2	-0.1	-0.1
Medication: Atorvastatin	0.2	0.3	0.5	-0.2	0.2	0.7	0.5	0.7
Illnesses of father: High blood pressure	1.2	1.5	2.2	-0.9	1.1	1.1	1.4	1.5
Alcohol drinker status: Never	0.6	0.7	1.3	-0.7	-0.5	-1.1	-1.1	-0.4
Ever smoked	0.6	1.1	2.2	1.5	0.8	0.8	1.3	0.5
Basal metabolic rate	0.4	2.0	5.1	-1.3	2.3	0.1	1.0	1.6
Leg fat percentage (left)	0.2	0.6	0.9	-0.9	0.8	0.7	0.3	0.9
Arm fat-free mass (left)	0.3	1.4	3.5	-1.1	1.9	0.1	1.0	1.2
Number of operations (self-reported)	0.5	0.7	1.6	1.3	-0.4	0.3	0.9	-0.9
Average weekly beer plus cider intake	0.3	0.5	1.1	-0.1	-0.9	0.3	1.1	0.5
Irritability	0.4	0.7	1.5	0.8	-1.2	-0.3	0.2	-1.2
Risk taking	0.8	1.2	2.7	-0.0	1.1	1.0	1.7	1.1
Ever had prostate specific antigen (PSA) test	1.6	1.9	3.1	0.6	1.4	1.7	1.8	1.1
Fractured/broken bones in last 5 years	3.7	4.8	10.3	3.2	-0.8	2.5	2.0	-1.8
Age started oral contraceptive pill	1.2	1.4	4.7	-0.5	2.2	-0.7	-1.1	0.7
Diastolic blood pressure, automated reading	0.0	0.0	0.1	0.2	-0.2	0.1	0.2	-0.3
Ever depressed for a whole week	0.3	0.4	1.2	-0.4	-0.5	-1.1	-0.1	-0.5
Unable to work because of sickness or disability	0.2	0.2	0.6	0.6	-0.4	0.8	0.4	-0.2
Commuting to job workplace: Cycle	2.3	2.8	7.5	-0.5	2.7	1.1	1.0	2.0
Myopia	1.2	1.8	2.9	-0.5	1.4	1.5	1.7	1.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	4.9	-2.2	0.7	-1.5	-1.0	1.5
Cholesterol lowering medication	1.5	2.2	5.2	-1.3	2.3	0.1	1.3	1.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.6	-1.3	-1.2	-0.6	-0.8	-0.6
Pain experienced in last month	0.2	0.4	1.6	0.1	1.3	0.2	0.3	-0.1
Supplements: Calcium	1.1	1.2	3.9	-0.6	2.0	0.9	0.3	1.0
Basal cell carcinoma (self-reported)	1.3	1.6	4.9	2.2	0.9	0.9	0.7	-1.0
Heart attack/myocardial infarction (self-reported)	4.7	6.0	7.9	2.1	-2.5	-2.4	-2.3	-2.8
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	4.0	0.8	-0.3	-2.0	-1.8	-1.5
Heart disease (siblings)	0.0	0.0	0.1	0.1	0.2	-0.0	0.1	-0.0
Alcohol drinker status: Previous	0.8	0.9	2.1	-1.5	-0.4	-1.2	-0.8	0.4
Pack years of smoking	0.1	0.1	0.3	-0.5	-0.1	-0.2	0.2	0.5
Impedance of whole body	0.7	3.7	6.3	2.2	-2.5	1.4	-0.8	-2.2
Leg fat mass (left)	0.2	0.7	1.4	-0.9	1.2	0.6	0.2	0.9
Arm predicted mass (left)	0.3	1.3	3.2	-1.0	1.8	0.2	1.1	1.2