Hub : Genes

AIFM2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2610	0.0370	0.0e+00	0.255	0.213	0.268	0.253	0.257	6.6e-31	1.7e-25	1.6e-32	1.5e-30	3.7e-31
2	GTEx	Brain Cerebellum	0.5340	0.1070	6.8e-05	0.277	NA	0.299	NA	0.341	8.3e-09	NA	1.6e-09	NA	7.4e-11
3	GTEx	Brain Cortex	0.4810	0.0900	1.8e-06	0.434	NA	0.469	NA	0.431	2.4e-13	NA	1.2e-14	NA	3.1e-13
4	GTEx	Cells EBV-transformed lymphocytes	0.4020	0.1130	4.3e-03	-0.009	NA	-0.005	NA	-0.007	9.7e-01	NA	4.9e-01	NA	6.5e-01
5	GTEx	Esophagus Mucosa	0.4040	0.0710	3.5e-07	0.413	NA	0.419	NA	0.413	1.3e-29	NA	4.0e-30	NA	1.6e-29
6	ROSMAP	Brain Pre-frontal Cortex	0.4339	0.0413	0.0e+00	0.411	0.345	0.442	0.425	0.459	4.5e-57	5.1e-46	1.5e-62	1.9e-59	7.4e-66
7	YFS	Blood	0.0666	0.0143	6.2e-12	0.009	0.037	0.058	0.042	0.054	4.9e-04	4.6e-12	1.8e-18	1.4e-13	4.6e-17

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.2	3.5	6.3	-1.9	-2.5	-1.6	1.3	-1.1	-2.5	-1.8
Bipolar Disorder or Schizophrenia	0.1	0.3	0.8	0.6	-0.2	0.7	-0.1	0.9	-0.3	0.2
Depressed Affect (Nagel 2018)	0.6	1.3	4.7	0.4	1.0	0.5	0.5	2.2	0.6	1.6
Depression (Nagel 2018)	0.3	0.4	1.3	-0.6	-1.1	-0.6	0.1	0.3	-0.9	0.0
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.3	2.0	0.8	2.3	-1.3	-0.7	1.6	0.5
Neuroticism (Nagel 2018)	0.6	1.3	4.8	0.2	0.6	-0.0	1.1	1.6	0.2	2.2
Schizophrenia (2018)	1.7	3.5	5.3	2.3	1.8	2.2	-1.1	2.1	1.6	1.7
Schizophrenia vs Biploar Disorder	0.8	1.0	3.5	0.7	1.1	1.1	0.7	1.9	0.7	0.3
Worry (Nagel 2018)	0.4	0.8	2.5	-0.2	-0.1	-0.4	1.6	0.9	-0.2	1.5
Alzheimer’s Disease (in mother)	3.5	4.1	5.6	2.1	2.4	1.9	-1.1	1.9	2.1	2.3
Alzheimer’s Disease (in father)	3.4	3.7	6.9	2.5	2.1	2.6	-1.7	-0.4	2.3	0.2
Alzheimer’s Disease (including proxy)	4.5	6.6	9.7	3.1	3.1	2.9	-1.6	1.6	2.7	2.4
Crohns Disease (2017)	0.4	0.9	2.1	-1.2	-1.0	-1.4	1.1	-0.4	-0.5	-0.3
Irritable Bowel Disease (IBD)	0.7	1.7	3.8	-1.5	-1.4	-2.0	1.5	0.2	-1.1	-0.6
Ulcerative Colitis (UC)	0.6	1.2	2.4	-1.2	-1.2	-1.5	0.9	0.4	-1.3	-0.8
Major Depression (MDD)	3.7	4.6	7.7	2.8	1.3	2.5	-1.7	-1.3	2.1	2.6
Reaction Time	0.3	0.5	2.7	0.5	-0.2	0.5	-0.1	1.6	-0.2	0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.5	1.5	0.6	1.6	-1.0	-1.1	1.3	0.3
Breast Cancer	1.0	2.5	5.3	-1.4	-1.9	-2.3	-0.4	-1.4	-2.0	-0.7
Ovarian Cancer	1.1	1.4	4.7	1.4	0.4	1.0	-2.2	0.3	1.0	-1.1
Prostate Cancer	0.2	0.2	0.4	-0.6	-0.4	-0.6	-0.2	0.4	-0.6	0.4
Age at First Birth	0.1	0.1	0.4	0.2	0.2	0.1	0.7	0.3	0.2	-0.6
Bipolar Disorder (2011)	0.6	0.6	1.2	-0.9	-0.8	-0.4	0.3	0.8	-1.1	-0.5
Body Mass Index (BMI) (2010)	0.1	0.1	0.6	-0.0	0.2	-0.0	-0.4	0.8	0.4	0.1
Coronary Artery Disease (CAD)	0.3	0.4	0.9	0.1	0.9	0.1	0.2	0.9	0.4	0.9
Crohns Disease (2012)	0.2	0.3	0.6	-0.6	-0.8	-0.3	0.7	0.3	-0.4	-0.3
Mean Putamen Volume	1.9	2.2	3.6	1.6	1.1	1.9	-1.3	0.6	1.7	1.8
Fasting Glucose	0.4	0.5	1.0	-0.7	-1.0	-0.7	-0.1	-0.5	-0.7	-0.8
HbA1C	1.6	1.8	6.9	-0.7	-1.2	-0.5	0.7	-1.5	-0.8	-2.6
HDL Cholesterol	2.0	3.3	5.2	2.3	1.7	2.0	-1.5	-0.9	1.9	2.1
LDL Cholesterol	2.4	3.8	11.8	1.2	1.9	1.4	1.5	3.4	1.6	1.8
Lupus	3.3	4.9	9.1	-1.9	-2.6	-2.0	0.9	-2.4	-2.0	-3.0
Neuroticism (2016)	0.3	0.5	1.5	0.5	0.8	0.0	0.2	0.8	0.4	1.2
Primary Biliary Cirrhosis	0.1	0.1	0.4	0.4	0.0	0.5	0.6	0.1	0.3	-0.3
Rheumatoid Arthritis	0.6	0.8	2.3	1.5	0.3	0.8	-0.5	-1.0	0.6	1.1
Schizophrenia (2014)	1.2	2.6	4.8	1.8	1.5	2.2	-0.7	2.1	1.5	1.0
Triglycerides	1.1	1.7	3.5	-1.5	-1.4	-1.4	0.7	-0.6	-1.3	-1.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.5	-0.6	0.3	0.1	0.6	1.6	-0.1	1.4
Ulcerative Colitis	0.9	1.3	6.9	-0.0	-0.6	-0.6	2.6	0.5	-1.0	0.3
Blood Eosinophil Count	0.1	0.7	2.1	1.2	0.2	0.6	-0.7	1.5	0.4	0.5
Blood Platelet Count	0.0	0.2	0.4	0.6	0.6	0.2	-0.3	0.2	0.5	0.7
Blood Red Count	1.5	14.3	26.9	5.2	3.8	4.4	-1.1	2.5	4.2	3.7
Blood White Count	0.1	0.9	2.9	0.8	0.3	0.6	-0.3	1.4	0.7	1.7
Heel T-Score	0.5	4.1	6.2	-2.2	-2.1	-2.5	2.1	-1.1	-2.3	-1.6
BMI	0.2	1.0	2.3	-0.9	-1.5	-1.2	0.5	0.1	-1.3	-0.3
Height	0.2	4.3	7.8	-2.0	-2.6	-2.3	-0.5	-1.7	-1.8	-2.8
Waist Hip Ratio (WHR)	0.1	0.5	1.7	-0.1	-1.3	-0.7	0.6	-0.2	-1.0	0.1
Systolic Blood Pressure	0.4	2.1	4.3	1.5	1.9	1.4	-0.1	-0.5	2.1	1.4
Smoking Status	0.3	0.8	1.8	-0.4	-1.2	-0.8	-1.4	-0.0	-1.1	-0.3
Allergy or Eczema	0.8	2.2	4.5	-1.4	-1.6	-1.0	2.1	0.8	-1.1	-1.9
Cardiovascular Disease	0.3	0.9	3.0	0.7	-0.1	0.5	1.4	-1.7	0.4	-0.2
Hypothyroidism (self reported)	2.5	5.7	11.6	2.7	3.1	2.6	0.8	0.6	3.4	1.8
Respiratory disease	0.5	1.0	3.9	-0.9	-1.0	-0.5	2.0	-0.2	-0.7	0.7
Type 2 Diabetes (T2D) (2018)	0.6	1.2	1.8	-1.1	-1.3	-1.4	0.9	-0.4	-1.4	-0.7
Lung FEV1/FVC ratio	1.3	6.5	11.2	-3.4	-2.3	-2.9	2.7	-1.0	-2.6	-2.4
Lung FVC	0.1	0.7	2.9	0.6	0.9	0.5	-0.1	1.7	0.5	0.8
Neuroticism	0.5	1.1	4.4	-0.2	0.6	0.0	0.7	2.1	0.4	1.6
Chronotype (morning person)	1.1	2.4	6.7	1.4	2.6	1.3	-0.1	0.9	1.7	1.7
Hair Pigment	0.0	1.4	5.6	0.6	1.4	0.6	1.0	2.4	0.6	0.2
Tanning	0.0	0.5	2.4	-0.1	0.4	0.3	1.0	-1.5	0.3	-0.1
Hand grip strength (left)	0.2	0.5	1.1	0.2	0.5	0.5	-0.6	-1.0	1.1	-0.8
Number of treatments/medications taken	0.7	1.3	4.2	0.3	-1.1	-0.1	2.1	-1.7	-0.0	-0.8
Average weekly spirits intake	0.2	0.2	0.6	-0.0	-0.7	-0.5	-0.5	0.3	-0.7	0.4
Sensitivity / hurt feelings	0.4	0.7	2.0	0.2	0.9	0.2	1.1	0.5	0.8	1.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.2	-0.6	-0.2	-0.1	0.4	0.5	-0.4	1.1
Hearing difficulty/problems: Yes	1.3	2.0	4.9	1.8	1.3	2.2	-0.6	0.8	1.6	1.0
Relative age of first facial hair	0.1	0.2	0.7	0.4	-0.3	-0.6	-0.8	-0.0	-0.4	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.1	0.2	-0.6	0.3	0.7	-1.0	-0.3	-0.0
Ever used hormone-replacement therapy (HRT)	2.4	3.0	6.7	-1.9	-2.6	-2.1	-0.1	-0.5	-2.2	-0.8
Ever had hysterectomy (womb removed)	1.0	1.2	3.0	0.7	1.7	1.3	-0.1	0.3	1.7	-0.2
Systolic blood pressure, automated reading	0.2	0.6	1.2	0.8	0.9	0.6	-0.6	0.4	1.1	0.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.7	0.4	0.5	-0.4	1.5	1.9	0.2	1.1
Angina	0.8	1.1	2.8	-0.7	-0.8	-0.7	1.7	-1.3	-0.3	-1.1
Medication for hormone replacement therapy	1.2	1.4	3.4	-1.0	-1.8	-1.1	-0.8	-0.8	-1.4	-0.9
Vitamin and mineral supplements	0.7	1.0	1.6	-1.2	-0.7	-1.1	0.8	1.3	-1.2	0.5
Supplements: Zinc	0.2	0.2	0.4	0.4	-0.5	0.3	-0.7	0.5	-0.3	-0.6
Medication: Co-codamol	0.5	0.5	2.0	0.4	0.1	0.5	1.4	0.8	0.4	0.7
Medication: Metformin	1.2	1.8	2.4	-1.2	-1.5	-1.4	1.3	0.1	-1.6	-1.5
Diabetes (father)	1.3	1.7	5.0	-1.0	-0.9	-1.4	2.2	-0.7	-1.6	-0.2
Diabetes (mother)	2.2	2.8	7.6	1.6	1.5	1.6	1.2	2.8	1.2	1.5
Severe depression (siblings)	0.6	0.7	2.3	-1.5	0.1	-0.8	1.4	0.1	-0.3	-0.3
Pack years adult smoking proportion	0.3	0.4	1.7	-0.6	0.0	-0.3	1.3	0.3	-0.2	-0.7
Impedance of leg (right)	0.2	1.0	2.3	1.2	1.5	1.0	-0.1	-0.8	1.1	0.3
Leg fat-free mass (left)	0.3	1.7	3.3	-1.5	-1.8	-1.5	0.1	0.2	-1.4	-1.4
Trunk fat percentage	0.2	0.8	1.3	0.2	-0.8	-1.0	0.9	0.8	-1.0	1.1
Hand grip strength (right)	0.7	2.0	4.3	1.4	1.6	1.7	-1.2	0.2	2.1	0.7
Townsend deprivation index at recruitment	0.4	0.6	1.4	0.9	0.4	1.2	-0.9	0.2	1.1	0.1
Current tobacco smoking	1.3	2.1	3.7	1.9	1.6	1.9	-0.9	1.1	1.3	1.1
Average weekly fortified wine intake	0.6	0.6	1.6	1.3	0.9	0.8	0.3	-0.4	0.7	-0.9
Maternal smoking around birth	0.8	1.2	3.2	0.9	0.6	0.1	0.9	1.7	0.4	1.8
Fed-up feelings	0.6	1.2	3.0	0.8	1.3	1.1	0.3	0.7	1.1	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	-0.5	-0.4	-0.3	0.3	0.2	-0.4	0.4
Relative age voice broke	0.4	0.6	0.9	-0.7	-0.8	-0.9	0.8	0.9	-0.9	0.4
Taking other prescription medications	1.4	2.2	5.5	-0.7	-1.9	-1.1	2.3	-1.2	-1.1	-1.4
Age when periods started (menarche)	0.2	0.5	1.4	0.8	-0.3	-0.4	-1.1	0.2	0.4	-1.2
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	8.0	0.4	0.9	0.8	-2.8	-1.0	0.9	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.5	-0.2	-1.2	-0.6	1.2	-0.3	-0.6	-0.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.9	0.1	-0.9	-0.1	1.0	-1.7	-0.6	1.7
Qualifications: CSEs or equivalent	0.5	0.7	1.8	-1.1	-0.1	-0.3	0.6	-1.2	0.1	-1.4
Serious illness, injury or assault to yourself	0.6	0.8	3.0	-0.7	-0.4	-0.9	1.7	-0.1	-0.8	-0.6
High blood pressure	0.3	0.9	1.9	1.0	0.2	0.9	1.4	-1.3	0.6	0.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.7	-0.3	-0.5	-0.2	0.9	-0.0	-0.3	-1.3
Multivitamins +/- minerals	1.1	1.4	2.5	1.6	0.9	1.5	-0.7	-1.2	1.6	0.2
Stomach or abdominal pain in last month	2.7	3.3	11.9	0.4	1.4	0.5	1.4	2.3	1.3	3.5
Supplements: Glucosamine	0.8	1.0	3.3	1.8	0.8	1.0	1.0	0.4	1.0	0.0
Diverticular disease/diverticulitis (self-reported)	3.4	4.0	9.4	-2.2	-1.8	-2.2	3.1	0.5	-2.3	-0.1
Medication: Atenolol	0.1	0.1	0.6	0.7	-0.1	0.5	-0.1	0.1	0.2	-0.1
Medication: Levothyroxine sodium	3.0	5.1	6.8	2.5	2.4	2.3	1.1	2.2	2.6	2.3
Sitting height	0.5	3.2	8.6	-1.3	-2.1	-1.7	-0.8	-1.7	-1.2	-2.9
Chronic bronchitis/emphysema (father)	0.9	1.1	3.6	1.0	1.0	0.6	-0.3	1.2	0.4	1.9
High blood pressure (mother)	0.1	0.2	0.7	-0.5	0.2	0.3	-0.2	-0.8	0.2	-0.2
Body mass index (BMI)	0.4	1.7	2.6	-1.0	-1.4	-1.6	1.6	1.0	-1.6	0.6
Impedance of leg (left)	0.3	1.4	2.9	1.6	1.7	1.1	-0.4	-0.7	1.3	0.8
Leg predicted mass (left)	0.3	1.7	3.4	-1.5	-1.8	-1.4	0.0	0.2	-1.4	-1.4
Trunk fat mass	0.3	1.2	2.7	-0.5	-1.5	-1.6	0.9	0.4	-1.5	0.3
Waist circumference	0.4	1.6	3.1	-0.9	-1.8	-1.6	1.2	0.6	-1.7	0.5
Number of incorrect matches in round	0.8	1.3	2.6	-1.6	-1.1	-1.5	0.2	0.7	-1.6	-0.6
Past tobacco smoking	1.0	1.8	4.4	1.2	2.1	1.5	0.5	0.8	1.7	0.6
Alcohol usually taken with meals	0.1	0.2	0.4	-0.5	-0.5	-0.1	0.2	0.6	-0.4	-0.2
Nervous feelings	0.6	1.1	5.3	-0.4	0.3	0.3	1.3	0.8	0.1	2.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.7	-0.6	0.5	0.0	1.1	1.4	0.1	1.6
Hearing difficulty/problems with background noise	0.5	0.9	1.9	1.2	0.6	1.4	1.0	0.5	0.6	0.9
Hair/balding pattern: Pattern 2	0.4	0.5	2.5	-0.3	0.7	0.3	1.6	-0.2	0.2	0.7
Had menopause	0.2	0.3	1.1	0.9	-0.0	-0.1	0.1	1.1	0.2	-0.4
Had other major operations	0.6	0.7	2.7	1.6	-0.1	0.3	-0.9	-0.9	0.8	0.1
Forced vital capacity (FVC)	0.1	0.3	1.0	-0.7	-0.1	-0.8	-1.0	0.5	-0.4	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.5	-0.4	-1.2	-0.9	1.0	-0.4	-0.6	-0.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	5.5	1.3	0.5	1.1	1.1	0.3	0.8	2.3
Qualifications: None of the above	0.2	0.4	1.0	-0.6	-0.7	-0.6	0.6	-0.5	-1.0	-0.1
Financial difficulties in last 2 years	0.4	0.5	2.2	0.0	0.4	0.6	-1.5	0.3	0.5	0.8
Mouth/teeth dental problems	1.9	2.9	7.0	-1.1	-1.7	-1.5	-1.3	-2.6	-1.0	-2.1
Heart attack	1.9	2.4	4.6	2.1	1.3	1.9	-1.0	2.0	1.4	0.6
Allergy	0.3	0.8	2.4	1.1	0.9	0.5	-1.5	-0.2	0.6	0.5
Pain all over the body in last month	0.1	0.1	0.1	0.3	0.2	0.2	-0.2	0.3	0.3	-0.1
Diabetes (self-reported)	0.6	0.9	1.7	-0.8	-1.0	-1.3	0.9	0.6	-1.2	-0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.5	-1.1	-0.7	-0.8	0.6	0.7	-0.4	-1.6
Medication: Ramipril	0.2	0.3	1.6	1.3	-0.3	0.6	-0.1	-0.1	0.3	0.2
Medication: Simvastatin	0.4	0.6	2.7	0.4	0.1	0.9	1.6	-0.6	0.5	0.2
Fluid intelligence score	0.7	1.6	3.4	1.8	1.0	1.4	-0.9	-0.9	1.7	0.1
Illnesses of siblings	1.3	1.8	3.1	1.4	1.5	1.3	-0.9	0.5	1.5	1.8
Neuroticism score	0.6	1.2	4.0	0.0	0.8	0.3	0.8	1.7	0.7	2.0
Weight	0.4	1.7	3.6	-1.2	-1.9	-1.9	0.6	0.1	-1.6	-0.7
Impedance of arm (right)	0.4	2.1	5.6	1.7	1.2	1.4	-2.4	-0.7	1.4	0.2
Arm fat percentage (right)	0.3	1.1	2.0	-0.5	-1.3	-1.3	0.8	1.0	-1.4	0.8
Trunk fat-free mass	0.7	3.9	8.9	-2.2	-2.4	-2.1	0.0	-0.5	-1.9	-3.0
Hip circumference	0.1	0.6	1.4	-0.5	-1.1	-1.2	0.1	0.2	-1.0	0.5
Time employed in main current job	0.5	0.6	1.3	-0.8	-0.8	-0.8	1.1	0.4	-0.8	-0.5
Alcohol intake versus 10 years previously	0.3	0.5	0.9	0.9	0.5	0.6	0.5	0.7	0.4	1.0
Father’s age at death	1.3	1.7	3.8	-1.8	-1.6	-1.5	0.3	-0.0	-1.9	-0.1
Worrier / anxious feelings	0.2	0.4	0.7	-0.8	-0.7	-0.7	0.3	0.1	-0.8	-0.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.0	1.1	1.3	1.4	-1.2	0.6	1.3	1.7
Falls in the last year	1.0	1.3	3.3	0.9	1.1	0.9	1.0	1.2	0.9	1.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.7	0.3	0.1	-0.7	0.2	0.5	0.8
Number of live births	0.3	0.4	2.2	0.7	-0.2	0.4	-1.5	-0.1	0.2	0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.7	-1.6	-0.7	-1.6	0.6	0.6	-1.2	-0.5
Pulse rate	0.8	1.3	2.2	-1.4	-1.5	-1.1	-0.4	0.1	-1.3	-1.4
Happiness	0.3	0.3	0.7	0.7	0.6	0.8	-0.1	0.1	0.6	0.7
Noisy workplace	1.2	1.5	2.9	-1.4	-1.7	-1.0	1.3	0.7	-1.5	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.7	-0.9	-0.4	-0.6	-0.1	-1.6	-0.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.6	-0.4	-0.4	-0.8	-0.8	-0.6	-0.6	0.8
Mouth/teeth dental problems: Dentures	1.1	1.9	7.4	0.3	0.5	0.1	1.7	2.7	-0.3	1.5
Asthma	0.4	0.7	1.8	-0.9	-0.9	-0.4	1.3	-0.4	-0.8	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.9	0.1	-0.4	-0.2	-1.0	-0.1	-0.1	-0.1
Medication: Cholesterol lowering	1.3	2.1	4.4	2.0	1.3	2.1	0.7	-0.7	1.8	0.1
Depression (self-reported)	2.6	3.1	6.3	-2.0	-1.9	-1.6	2.5	0.6	-2.2	-0.3
Medication: Lansoprazole	0.5	0.5	1.2	-0.4	-1.0	-0.6	0.4	-0.5	-1.1	0.8
Prospective memory result	0.3	0.3	1.3	0.3	0.4	0.0	-0.4	0.7	0.2	1.1
Lung cancer (father)	1.3	1.5	4.5	-0.6	-1.2	-1.7	2.1	0.9	-0.9	-0.2
Illnesses of mother	0.1	0.1	0.4	-0.1	0.0	-0.6	0.1	-0.2	-0.2	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.1	-1.1	-0.2	-0.8	0.6	0.0	-0.6	-0.2
Pulse wave Arterial Stiffness index	0.9	1.0	1.8	-1.4	-1.1	-1.0	0.6	-0.7	-1.1	-0.9
Impedance of arm (left)	0.5	2.4	4.9	1.9	1.5	1.5	-2.2	-0.1	1.6	0.9
Arm fat mass (right)	0.3	1.4	2.7	-0.7	-1.7	-1.6	0.9	0.7	-1.6	0.5
Trunk predicted mass	0.6	3.6	8.0	-2.1	-2.3	-2.0	0.0	-0.5	-1.8	-2.8
Standing height	0.3	2.9	7.6	-0.7	-1.4	-0.8	-2.3	-2.1	-0.4	-2.8
Length of working week for main job	1.0	1.2	6.2	0.6	1.0	0.6	0.2	2.5	0.1	0.4
Exposure to tobacco smoke at home	0.5	0.5	1.0	0.7	0.6	1.0	-0.1	0.8	1.0	0.6
Breastfed as a baby	0.1	0.2	0.5	0.1	-0.1	0.2	-0.7	0.2	0.4	-0.6
Tense / ‘highly strung’	0.4	0.7	1.8	0.9	0.8	0.6	-0.1	0.2	1.0	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	-0.2	-0.8	0.0	1.0	0.4	-0.6	1.0
Hair/balding pattern: Pattern 4	1.0	2.4	5.8	1.7	1.2	1.7	-0.3	2.4	1.2	1.5
Birth weight of first child	0.1	0.2	0.4	-0.1	-0.6	-0.5	0.5	-0.2	-0.5	0.0
Peak expiratory flow (PEF)	0.5	1.1	2.8	-1.7	-0.2	-1.5	0.7	1.0	-0.7	-0.9
Pulse wave reflection index	0.4	0.5	2.0	0.3	0.8	0.6	-0.1	-0.0	0.4	1.4
Ever highly irritable/argumentative for 2 days	1.7	2.0	7.8	0.9	0.6	1.0	0.8	1.8	0.5	2.8
Loud music exposure frequency	0.0	0.1	0.1	0.3	0.2	0.3	0.3	0.3	0.1	0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.1	-0.7	-0.3	-0.6	-0.6	-1.1	0.0	-0.9
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	4.7	0.1	0.6	1.0	1.2	2.2	0.5	0.4
Blood clot in the leg (DVT)	1.5	1.9	2.9	1.4	1.3	1.6	0.4	1.3	1.7	1.6
Medication: Paracetamol	0.3	0.6	1.3	-0.9	-0.9	-0.9	0.1	-0.4	-1.1	-0.3
Headache pain in last month	0.1	0.2	1.1	-0.5	0.2	-0.1	1.0	-0.2	-0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.2	-1.8	-0.7	-1.5	-0.2	1.5	-1.5	0.2
Glaucoma (self-reported)	0.7	0.8	2.4	0.9	0.9	1.6	-0.5	0.5	1.1	-0.3
Gout (self-reported)	0.5	0.6	1.8	-0.1	-1.2	-0.5	0.1	-1.4	-0.5	0.8
Hypothyroidism/myxoedema (self-reported)	3.2	6.3	9.8	2.9	3.0	2.9	0.7	1.5	3.1	2.5
Medication: Amlodipine	0.5	0.7	2.2	0.3	0.2	0.8	1.5	-0.1	0.3	1.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.0	0.1	0.3	-0.5	0.2	0.1	0.7
Birth weight	0.2	0.4	1.4	-0.5	-1.2	-0.3	-0.4	0.1	-0.7	0.4
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.1	-0.6	-1.5	-0.6	2.0	1.1	-1.3	-0.0
High blood pressure (siblings)	3.5	5.0	7.2	-2.4	-2.5	-2.7	1.3	-0.8	-2.7	-2.5
Forced vital capacity (FVC), Best measure	0.0	0.1	0.6	-0.2	0.2	-0.0	-0.8	-0.2	0.1	0.3
Body fat percentage	0.3	1.1	2.0	-0.3	-1.1	-1.4	1.1	0.5	-1.4	1.0
Leg fat percentage (right)	0.5	1.8	4.2	-0.8	-1.3	-1.6	2.0	0.5	-1.7	0.7
Arm fat-free mass (right)	0.4	1.9	3.1	-1.6	-1.7	-1.8	0.4	0.1	-1.6	-1.4
Exposure to tobacco smoke outside home	0.2	0.2	0.7	-0.1	-0.6	-0.4	-0.8	-0.0	-0.4	0.4
Comparative body size at age 10	0.5	1.4	2.5	1.1	0.4	1.6	-1.5	-1.3	0.8	1.1
Number of full brothers	0.4	0.5	1.2	0.9	0.7	1.1	-0.2	0.3	0.8	0.0
Worry too long after embarrassment	0.9	1.5	4.4	-0.2	0.7	-0.4	1.5	1.8	0.2	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.1	-0.5	-1.0	0.3	0.5	1.5	-0.8	0.2
Wheeze or whistling in the chest in last year	0.4	0.7	2.3	0.6	0.4	0.5	1.5	0.3	0.5	1.1
Number of children fathered	1.2	1.3	3.6	-0.9	-1.6	-1.4	-0.1	0.3	-1.9	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.6	0.6	1.6	0.8	-0.9	1.3	1.1	0.1
Age at first live birth	0.2	0.3	0.8	0.9	0.3	0.4	0.5	-0.4	0.6	0.4
Pulse wave peak to peak time	1.1	1.3	2.4	1.6	1.2	1.2	-1.0	0.4	1.4	0.8
Health satisfaction	0.9	1.1	4.5	0.6	0.0	0.4	1.2	2.1	-0.3	1.2
Shortness of breath walking on level ground	1.2	1.5	3.4	-0.9	0.1	-0.7	1.6	1.6	-0.8	1.9
Qualifications: College or University degree	0.2	0.7	2.5	0.4	0.6	0.7	0.6	-1.6	1.1	0.3
Eye problems/disorders: None of the above	0.4	0.4	0.8	-0.9	-0.2	-0.1	-0.8	-0.7	-0.3	-0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	0.2	0.1	0.9	-0.4	-0.9	0.5	-0.2
Emphysema/chronic bronchitis	0.5	0.6	1.3	-1.2	-1.1	-0.7	0.2	0.4	-0.7	-0.4
Medication for pain relief, constipation, heartburn	0.2	0.4	1.5	0.3	0.6	0.4	-1.2	0.1	0.6	0.5
Neck or shoulder pain in last month	0.5	0.7	2.7	-0.1	-0.4	-0.5	-1.2	-1.7	0.1	-0.5
Medication: Blood pressure	0.6	1.0	3.6	0.6	-0.9	-0.1	-0.4	-1.9	-0.0	-1.5
Angina (self-reported)	0.8	1.1	3.5	-0.6	-0.6	-0.6	1.9	-1.5	-0.1	-1.0
Migraine (self-reported)	0.9	1.1	2.4	-1.2	-0.5	-1.5	1.6	-0.1	-1.2	-0.5
Medication: Ibuprofen	0.1	0.1	0.4	0.2	-0.1	-0.2	-0.6	-0.3	0.1	-0.2
Medication: Allopurinol	0.3	0.4	1.1	-0.6	-0.9	-0.7	0.2	-1.1	-0.4	0.1
Medication: Omeprazole	0.6	0.7	2.7	0.6	0.1	0.3	1.6	0.7	0.1	1.1
Medication: Seretide 50 evohaler	0.3	0.3	0.9	-0.5	-0.9	-0.3	0.7	-0.2	-0.8	0.3
Mean time to correctly identify matches	0.5	0.9	4.3	-0.2	-0.6	-0.3	0.6	2.1	-0.8	0.7
Heart disease (mother)	2.0	2.5	5.3	-2.1	-1.6	-1.5	0.7	-0.7	-1.3	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.3	-1.5	-1.1	-1.3	1.4	1.1	-1.1	-0.8
Whole body fat mass	0.3	1.3	2.7	-0.6	-1.6	-1.6	1.0	0.4	-1.5	0.3
Leg fat mass (right)	0.4	1.4	2.5	-0.9	-1.5	-1.6	1.4	0.3	-1.5	0.4
Arm predicted mass (right)	0.4	2.1	3.3	-1.6	-1.8	-1.8	0.5	0.2	-1.7	-1.5
Pulse rate, automated reading	0.7	2.4	5.1	-2.3	-1.5	-2.0	0.3	0.5	-1.9	-1.2
Alcohol intake frequency.	0.3	0.8	2.4	-0.3	0.3	-0.4	1.5	1.3	-0.3	0.8
Comparative height size at age 10	0.4	2.4	6.0	0.2	-1.4	0.1	-2.3	-1.7	-0.4	-2.5
Number of full sisters	0.4	0.5	0.9	-0.9	-0.4	-0.9	0.8	-0.2	-1.0	-0.1
Suffer from ‘nerves’	1.5	2.4	4.4	-2.1	-1.1	-1.4	1.9	0.5	-1.7	1.6
Overall health rating	0.1	0.2	0.9	-0.2	-0.5	-0.1	-0.3	0.9	-0.4	0.4
Chest pain or discomfort	1.0	1.5	2.4	0.9	1.5	1.4	1.0	-0.4	1.6	1.2
Had major operations	0.8	0.9	6.0	0.0	-0.0	-0.1	2.4	-0.4	0.0	-0.1
Age at last live birth	0.5	0.7	1.7	0.8	0.2	1.1	1.1	-1.3	0.6	-0.2
Family relationship satisfaction	0.2	0.3	0.8	0.2	0.1	0.7	-0.9	-0.7	0.4	0.1
Leg pain on walking	0.7	0.9	2.9	-0.0	-0.7	-0.3	0.5	1.7	-0.6	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.2	-1.1	-0.5	-0.8	1.5	1.2	-1.1	0.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.4	0.2	0.4	0.6	1.8	0.1	0.5	1.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.9	0.7	-0.2	0.7	-0.9	-1.0	0.2	-0.1
Medication: Aspirin	1.0	1.3	5.1	-0.4	-0.5	-0.4	2.2	-1.2	-0.4	-1.4
Supplements: Vitamin C	0.3	0.4	1.1	1.0	1.0	0.4	-0.4	0.1	0.7	0.1
Knee pain experienced in last month	0.1	0.2	0.9	-0.3	0.2	-0.3	-0.2	0.9	-0.0	0.2
Hypertension (Self-reported)	0.3	0.7	2.0	1.0	-0.0	0.6	1.3	-1.4	0.4	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	0.9	0.6	0.6	0.6	0.1	0.6	1.0
Illnesses of father: Heart disease	1.2	1.6	4.4	-1.3	-1.3	-1.0	-0.0	-1.2	-0.9	-2.1
Illnesses of siblings: Diabetes	0.8	0.9	1.8	0.9	1.3	1.3	-0.9	0.8	0.9	-0.2
Smoking status: Previous	2.0	3.0	5.8	-1.8	-2.4	-2.0	-0.8	-1.7	-1.9	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.9	0.7	0.7	0.3	-1.4	-1.1	1.0	0.4
Whole body fat-free mass	0.6	3.2	5.5	-2.0	-2.3	-2.0	0.1	-0.2	-1.8	-2.4
Leg fat-free mass (right)	0.2	1.2	2.8	-1.3	-1.7	-1.3	-0.2	0.2	-1.1	-1.1
Arm fat percentage (left)	0.3	1.2	1.8	-0.3	-1.2	-1.2	0.9	1.2	-1.4	1.2
Average weekly red wine intake	1.5	2.2	4.7	-1.3	-1.3	-0.7	-1.9	-1.6	-1.0	-2.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.4	0.4	1.0	-0.0	-0.9	-2.1	1.3	-0.2
Mood swings	0.6	1.1	4.2	-0.3	0.8	0.0	0.7	1.4	0.5	2.0
Loneliness, isolation	1.6	2.2	4.6	1.3	1.5	1.4	0.4	1.8	1.2	2.1
Long-standing illness, disability or infirmity	0.2	0.3	1.0	-0.2	-1.0	-0.6	0.7	0.0	-0.7	-0.1
Ever had bowel cancer screening	3.2	3.7	5.3	-2.3	-2.3	-2.0	1.2	-0.9	-2.3	-2.1
Diabetes diagnosed by doctor	0.5	0.8	1.5	-0.8	-1.1	-1.2	0.6	0.2	-1.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	4.7	0.1	0.5	0.4	-2.2	-0.1	0.5	-1.5
Friendships satisfaction	0.7	0.9	4.5	0.4	0.1	1.0	-2.1	-0.7	0.4	0.3
Qualifications: nursing, teaching	1.2	1.9	4.5	1.5	1.9	1.7	-0.2	0.1	2.1	-0.0
Commuting to job workplace: Walk	0.1	0.1	0.5	0.4	0.2	-0.1	-0.7	0.2	0.1	0.2
Eye problems/disorders: Cataract	1.3	1.5	3.1	1.8	1.4	0.7	-1.3	-0.4	1.3	1.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.7	-0.1	0.6	-0.1	1.3	0.1	0.2	0.3
Medication for cholesterol	0.5	0.8	4.4	0.0	0.5	0.2	-2.1	-0.4	0.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.7	1.0	1.3	0.5	0.8	0.1	1.2	1.1
Back pain experienced in last month	0.2	0.3	1.2	0.6	-0.3	0.5	0.3	-1.1	0.2	-0.5
Mineral and other dietary supplements	1.1	1.5	2.9	-1.7	-0.6	-1.5	0.6	1.1	-1.3	1.3
Breast cancer (self-reported)	0.2	0.2	0.4	0.1	-0.5	-0.3	0.5	-0.5	-0.2	0.6
Asthma (self-reported)	0.4	0.8	2.6	-0.9	-0.8	-0.5	1.6	-0.3	-0.7	0.7
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.4	0.2	-0.3	0.6	-0.2	-0.2	-0.6
Osteoarthritis (self-reported)	0.1	0.1	0.5	-0.1	-0.2	-0.1	-0.2	-0.6	-0.2	0.7
Medication: Aspirin	0.9	1.2	4.8	-0.4	-0.6	-0.6	2.2	-0.9	-0.7	-1.1
Medication: Gliclazide	0.2	0.2	0.5	-0.5	-0.3	-0.6	0.4	0.1	-0.6	-0.7
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	-0.1	-0.3	-0.1	-0.6	-0.3	0.0	-0.5
Smoking status: Current	0.9	1.4	2.4	1.5	1.2	1.4	-0.9	1.2	1.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.4	-0.6	0.0	-0.5	1.2	0.9	-0.4	0.3
Whole body water mass	0.5	2.8	4.8	-1.9	-2.2	-1.9	0.0	-0.2	-1.7	-2.1
Leg predicted mass (right)	0.3	1.4	3.0	-1.4	-1.7	-1.3	-0.1	0.2	-1.2	-1.2
Arm fat mass (left)	0.4	1.6	3.1	-0.7	-1.8	-1.7	0.8	0.8	-1.7	0.5
Number of self-reported non-cancer illnesses	0.6	1.1	4.6	0.0	-0.6	-0.0	2.1	-1.6	0.2	-0.1
Average weekly champagne plus white wine intake	0.9	1.2	4.5	0.4	1.2	0.9	-2.1	0.5	1.2	-0.3
Miserableness	0.1	0.1	0.8	-0.3	0.2	-0.0	-0.0	0.2	0.1	0.9
Guilty feelings	0.5	0.7	2.9	0.4	1.0	0.4	0.5	0.2	0.8	1.7
Wears glasses or contact lenses	0.2	0.2	1.0	1.0	-0.3	0.0	0.4	0.4	-0.1	0.2
Ever taken oral contraceptive pill	0.5	0.6	1.9	-1.0	-0.8	-1.4	0.0	0.2	-0.5	0.4
Hearing aid user	0.9	1.0	1.9	1.4	1.2	0.8	0.7	0.9	1.1	1.0
Mother’s age at death	0.3	0.3	1.2	0.5	0.2	0.4	-1.1	-0.3	0.3	0.7
Financial situation satisfaction	0.5	0.6	1.8	0.9	0.5	0.8	-0.2	0.7	0.4	1.4
Tinnitus: Yes, now most or all of the time	1.9	2.3	4.0	-1.1	-1.9	-1.7	-0.2	-2.0	-1.4	-1.5
Commuting to job workplace: Public transport	0.3	0.4	1.7	0.0	-0.1	0.6	0.6	-0.4	0.2	-1.3
Eye problems/disorders: Glaucoma	0.4	0.4	0.8	0.7	0.8	0.8	-0.4	0.2	0.9	-0.7
Medication: Blood pressure	0.9	1.7	9.7	0.5	0.0	0.1	3.1	0.7	-0.1	1.1
Pain type(s) experienced in last month: Hip pain	1.1	1.3	5.7	0.9	0.4	0.5	-1.0	1.0	0.6	2.4
Supplements: Fish oil (including cod liver oil)	2.1	2.7	5.6	2.4	1.6	2.2	-0.8	-1.1	2.1	-0.2
High cholesterol (Self-reported)	0.5	0.8	3.4	0.7	0.3	1.0	1.8	-0.3	0.8	-0.0
Medication: Bendroflumethiazide	1.7	2.6	5.6	-1.6	-1.8	-1.2	2.4	-0.4	-1.8	-1.6
Medication: Paracetamol	0.2	0.3	1.0	-0.6	-0.6	-0.7	0.3	-0.3	-1.0	-0.1
Medication: Lisinopril	0.4	0.5	2.9	0.5	-0.6	0.2	1.7	0.0	-0.2	0.2
Medication: Atorvastatin	0.6	0.8	1.7	-0.8	-0.6	-0.6	1.2	0.3	-0.8	-1.3
Illnesses of father: High blood pressure	0.7	0.8	1.3	-0.9	-0.8	-1.2	1.2	-0.7	-1.1	-0.0
Alcohol drinker status: Never	0.4	0.5	2.2	0.2	0.7	0.2	0.6	1.5	0.0	0.1
Ever smoked	0.8	1.4	3.0	-0.7	-1.7	-0.6	-0.9	-1.3	-1.5	-1.2
Basal metabolic rate	0.5	2.7	4.9	-1.8	-2.2	-2.0	0.3	-0.0	-1.8	-1.8
Leg fat percentage (left)	0.4	1.6	3.2	-0.5	-1.2	-1.6	1.8	0.5	-1.5	1.0
Arm fat-free mass (left)	0.4	2.1	4.0	-1.6	-2.0	-1.7	0.3	-0.0	-1.7	-1.5
Number of operations (self-reported)	0.3	0.4	1.2	1.1	0.5	0.0	0.3	-0.7	1.0	-0.1
Average weekly beer plus cider intake	0.2	0.2	0.9	-0.3	-0.0	-0.1	0.9	-0.1	-0.3	0.6
Irritability	1.6	2.8	6.6	1.6	1.2	1.1	-2.6	0.6	1.2	2.4
Risk taking	0.6	0.9	2.3	-1.0	-0.4	-1.0	0.8	-1.5	-0.9	-0.8
Ever had prostate specific antigen (PSA) test	2.5	2.9	5.0	-1.6	-2.0	-1.6	0.0	-2.2	-1.6	-1.9
Fractured/broken bones in last 5 years	2.9	3.7	7.7	1.9	1.7	2.1	1.4	-2.8	2.1	0.8
Age started oral contraceptive pill	0.3	0.4	1.2	-0.7	-0.1	-0.7	0.5	0.3	-0.1	-1.1
Diastolic blood pressure, automated reading	0.0	0.1	0.2	0.3	0.1	-0.0	-0.5	0.0	0.4	0.3
Ever depressed for a whole week	0.8	0.9	4.0	0.7	0.1	-0.1	1.3	0.5	0.4	2.0
Unable to work because of sickness or disability	0.2	0.3	1.0	0.3	-0.2	0.0	1.0	-0.6	0.1	-0.5
Commuting to job workplace: Cycle	2.9	3.5	6.3	-2.1	-1.7	-2.1	1.4	-1.0	-1.8	-2.5
Myopia	1.5	2.1	5.9	-1.3	-1.4	-0.8	1.4	-1.3	-1.0	-2.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.4	-1.4	-0.5	-1.2	-1.5	1.5	-1.0	0.3
Cholesterol lowering medication	1.7	2.5	4.1	-1.9	-1.8	-1.8	2.0	-0.1	-1.9	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.6	0.7	0.2	0.1	1.6	1.3	0.0	1.0
Pain experienced in last month	0.1	0.1	0.3	0.2	-0.5	-0.0	0.2	-0.5	-0.4	0.1
Supplements: Calcium	0.8	0.9	1.9	-1.2	-1.1	-0.7	0.1	-0.4	-0.8	-1.4
Basal cell carcinoma (self-reported)	0.8	1.0	3.0	1.0	0.2	1.2	-0.7	-1.7	0.5	0.6
Heart attack/myocardial infarction (self-reported)	2.7	3.4	6.9	2.6	1.6	2.3	-1.4	1.9	1.7	0.8
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	3.6	1.5	1.5	1.7	0.5	1.3	1.8	1.9
Heart disease (siblings)	0.2	0.2	1.2	-0.3	0.2	0.2	1.1	0.2	0.2	0.4
Alcohol drinker status: Previous	0.5	0.5	2.0	-0.2	0.9	0.5	0.6	1.4	0.4	0.2
Pack years of smoking	0.2	0.3	1.4	-0.6	-0.1	-0.4	1.2	0.2	-0.2	-0.7
Impedance of whole body	0.5	2.6	4.8	2.2	1.9	1.7	-1.7	-0.5	1.7	1.2
Leg fat mass (left)	0.4	1.5	2.7	-0.8	-1.5	-1.7	1.4	0.3	-1.5	0.5
Arm predicted mass (left)	0.4	1.9	3.3	-1.5	-1.8	-1.7	0.4	-0.1	-1.5	-1.5