Hub : Genes

AIFM2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2610 0.0370 0.0e+00 0.255 0.213 0.268 0.253 0.257 6.6e-31 1.7e-25 1.6e-32 1.5e-30 3.7e-31
2 GTEx Brain Cerebellum 0.5340 0.1070 6.8e-05 0.277 NA 0.299 NA 0.341 8.3e-09 NA 1.6e-09 NA 7.4e-11
3 GTEx Brain Cortex 0.4810 0.0900 1.8e-06 0.434 NA 0.469 NA 0.431 2.4e-13 NA 1.2e-14 NA 3.1e-13
4 GTEx Cells EBV-transformed lymphocytes 0.4020 0.1130 4.3e-03 -0.009 NA -0.005 NA -0.007 9.7e-01 NA 4.9e-01 NA 6.5e-01
5 GTEx Esophagus Mucosa 0.4040 0.0710 3.5e-07 0.413 NA 0.419 NA 0.413 1.3e-29 NA 4.0e-30 NA 1.6e-29
6 ROSMAP Brain Pre-frontal Cortex 0.4339 0.0413 0.0e+00 0.411 0.345 0.442 0.425 0.459 4.5e-57 5.1e-46 1.5e-62 1.9e-59 7.4e-66
7 YFS Blood 0.0666 0.0143 6.2e-12 0.009 0.037 0.058 0.042 0.054 4.9e-04 4.6e-12 1.8e-18 1.4e-13 4.6e-17

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 2.2 3.5 6.3 -1.9 -2.5 -1.6 1.3 -1.1 -2.5 -1.8
Bipolar Disorder or Schizophrenia 0.1 0.3 0.8 0.6 -0.2 0.7 -0.1 0.9 -0.3 0.2
Depressed Affect (Nagel 2018) 0.6 1.3 4.7 0.4 1.0 0.5 0.5 2.2 0.6 1.6
Depression (Nagel 2018) 0.3 0.4 1.3 -0.6 -1.1 -0.6 0.1 0.3 -0.9 0.0
Intelligence (Savage-Jansen 2018) 0.7 2.2 5.3 2.0 0.8 2.3 -1.3 -0.7 1.6 0.5
Neuroticism (Nagel 2018) 0.6 1.3 4.8 0.2 0.6 -0.0 1.1 1.6 0.2 2.2
Schizophrenia (2018) 1.7 3.5 5.3 2.3 1.8 2.2 -1.1 2.1 1.6 1.7
Schizophrenia vs Biploar Disorder 0.8 1.0 3.5 0.7 1.1 1.1 0.7 1.9 0.7 0.3
Worry (Nagel 2018) 0.4 0.8 2.5 -0.2 -0.1 -0.4 1.6 0.9 -0.2 1.5
Alzheimer’s Disease (in mother) 3.5 4.1 5.6 2.1 2.4 1.9 -1.1 1.9 2.1 2.3
Alzheimer’s Disease (in father) 3.4 3.7 6.9 2.5 2.1 2.6 -1.7 -0.4 2.3 0.2
Alzheimer’s Disease (including proxy) 4.5 6.6 9.7 3.1 3.1 2.9 -1.6 1.6 2.7 2.4
Crohns Disease (2017) 0.4 0.9 2.1 -1.2 -1.0 -1.4 1.1 -0.4 -0.5 -0.3
Irritable Bowel Disease (IBD) 0.7 1.7 3.8 -1.5 -1.4 -2.0 1.5 0.2 -1.1 -0.6
Ulcerative Colitis (UC) 0.6 1.2 2.4 -1.2 -1.2 -1.5 0.9 0.4 -1.3 -0.8
Major Depression (MDD) 3.7 4.6 7.7 2.8 1.3 2.5 -1.7 -1.3 2.1 2.6
Reaction Time 0.3 0.5 2.7 0.5 -0.2 0.5 -0.1 1.6 -0.2 0.5
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.5 1.5 0.6 1.6 -1.0 -1.1 1.3 0.3
Breast Cancer 1.0 2.5 5.3 -1.4 -1.9 -2.3 -0.4 -1.4 -2.0 -0.7
Ovarian Cancer 1.1 1.4 4.7 1.4 0.4 1.0 -2.2 0.3 1.0 -1.1
Prostate Cancer 0.2 0.2 0.4 -0.6 -0.4 -0.6 -0.2 0.4 -0.6 0.4
Age at First Birth 0.1 0.1 0.4 0.2 0.2 0.1 0.7 0.3 0.2 -0.6
Bipolar Disorder (2011) 0.6 0.6 1.2 -0.9 -0.8 -0.4 0.3 0.8 -1.1 -0.5
Body Mass Index (BMI) (2010) 0.1 0.1 0.6 -0.0 0.2 -0.0 -0.4 0.8 0.4 0.1
Coronary Artery Disease (CAD) 0.3 0.4 0.9 0.1 0.9 0.1 0.2 0.9 0.4 0.9
Crohns Disease (2012) 0.2 0.3 0.6 -0.6 -0.8 -0.3 0.7 0.3 -0.4 -0.3
Mean Putamen Volume 1.9 2.2 3.6 1.6 1.1 1.9 -1.3 0.6 1.7 1.8
Fasting Glucose 0.4 0.5 1.0 -0.7 -1.0 -0.7 -0.1 -0.5 -0.7 -0.8
HbA1C 1.6 1.8 6.9 -0.7 -1.2 -0.5 0.7 -1.5 -0.8 -2.6
HDL Cholesterol 2.0 3.3 5.2 2.3 1.7 2.0 -1.5 -0.9 1.9 2.1
LDL Cholesterol 2.4 3.8 11.8 1.2 1.9 1.4 1.5 3.4 1.6 1.8
Lupus 3.3 4.9 9.1 -1.9 -2.6 -2.0 0.9 -2.4 -2.0 -3.0
Neuroticism (2016) 0.3 0.5 1.5 0.5 0.8 0.0 0.2 0.8 0.4 1.2
Primary Biliary Cirrhosis 0.1 0.1 0.4 0.4 0.0 0.5 0.6 0.1 0.3 -0.3
Rheumatoid Arthritis 0.6 0.8 2.3 1.5 0.3 0.8 -0.5 -1.0 0.6 1.1
Schizophrenia (2014) 1.2 2.6 4.8 1.8 1.5 2.2 -0.7 2.1 1.5 1.0
Triglycerides 1.1 1.7 3.5 -1.5 -1.4 -1.4 0.7 -0.6 -1.3 -1.9
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.5 -0.6 0.3 0.1 0.6 1.6 -0.1 1.4
Ulcerative Colitis 0.9 1.3 6.9 -0.0 -0.6 -0.6 2.6 0.5 -1.0 0.3
Blood Eosinophil Count 0.1 0.7 2.1 1.2 0.2 0.6 -0.7 1.5 0.4 0.5
Blood Platelet Count 0.0 0.2 0.4 0.6 0.6 0.2 -0.3 0.2 0.5 0.7
Blood Red Count 1.5 14.3 26.9 5.2 3.8 4.4 -1.1 2.5 4.2 3.7
Blood White Count 0.1 0.9 2.9 0.8 0.3 0.6 -0.3 1.4 0.7 1.7
Heel T-Score 0.5 4.1 6.2 -2.2 -2.1 -2.5 2.1 -1.1 -2.3 -1.6
BMI 0.2 1.0 2.3 -0.9 -1.5 -1.2 0.5 0.1 -1.3 -0.3
Height 0.2 4.3 7.8 -2.0 -2.6 -2.3 -0.5 -1.7 -1.8 -2.8
Waist Hip Ratio (WHR) 0.1 0.5 1.7 -0.1 -1.3 -0.7 0.6 -0.2 -1.0 0.1
Systolic Blood Pressure 0.4 2.1 4.3 1.5 1.9 1.4 -0.1 -0.5 2.1 1.4
Smoking Status 0.3 0.8 1.8 -0.4 -1.2 -0.8 -1.4 -0.0 -1.1 -0.3
Allergy or Eczema 0.8 2.2 4.5 -1.4 -1.6 -1.0 2.1 0.8 -1.1 -1.9
Cardiovascular Disease 0.3 0.9 3.0 0.7 -0.1 0.5 1.4 -1.7 0.4 -0.2
Hypothyroidism (self reported) 2.5 5.7 11.6 2.7 3.1 2.6 0.8 0.6 3.4 1.8
Respiratory disease 0.5 1.0 3.9 -0.9 -1.0 -0.5 2.0 -0.2 -0.7 0.7
Type 2 Diabetes (T2D) (2018) 0.6 1.2 1.8 -1.1 -1.3 -1.4 0.9 -0.4 -1.4 -0.7
Lung FEV1/FVC ratio 1.3 6.5 11.2 -3.4 -2.3 -2.9 2.7 -1.0 -2.6 -2.4
Lung FVC 0.1 0.7 2.9 0.6 0.9 0.5 -0.1 1.7 0.5 0.8
Neuroticism 0.5 1.1 4.4 -0.2 0.6 0.0 0.7 2.1 0.4 1.6
Chronotype (morning person) 1.1 2.4 6.7 1.4 2.6 1.3 -0.1 0.9 1.7 1.7
Hair Pigment 0.0 1.4 5.6 0.6 1.4 0.6 1.0 2.4 0.6 0.2
Tanning 0.0 0.5 2.4 -0.1 0.4 0.3 1.0 -1.5 0.3 -0.1
Hand grip strength (left) 0.2 0.5 1.1 0.2 0.5 0.5 -0.6 -1.0 1.1 -0.8
Number of treatments/medications taken 0.7 1.3 4.2 0.3 -1.1 -0.1 2.1 -1.7 -0.0 -0.8
Average weekly spirits intake 0.2 0.2 0.6 -0.0 -0.7 -0.5 -0.5 0.3 -0.7 0.4
Sensitivity / hurt feelings 0.4 0.7 2.0 0.2 0.9 0.2 1.1 0.5 0.8 1.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.2 -0.6 -0.2 -0.1 0.4 0.5 -0.4 1.1
Hearing difficulty/problems: Yes 1.3 2.0 4.9 1.8 1.3 2.2 -0.6 0.8 1.6 1.0
Relative age of first facial hair 0.1 0.2 0.7 0.4 -0.3 -0.6 -0.8 -0.0 -0.4 0.5
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.1 0.2 -0.6 0.3 0.7 -1.0 -0.3 -0.0
Ever used hormone-replacement therapy (HRT) 2.4 3.0 6.7 -1.9 -2.6 -2.1 -0.1 -0.5 -2.2 -0.8
Ever had hysterectomy (womb removed) 1.0 1.2 3.0 0.7 1.7 1.3 -0.1 0.3 1.7 -0.2
Systolic blood pressure, automated reading 0.2 0.6 1.2 0.8 0.9 0.6 -0.6 0.4 1.1 0.7
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 3.7 0.4 0.5 -0.4 1.5 1.9 0.2 1.1
Angina 0.8 1.1 2.8 -0.7 -0.8 -0.7 1.7 -1.3 -0.3 -1.1
Medication for hormone replacement therapy 1.2 1.4 3.4 -1.0 -1.8 -1.1 -0.8 -0.8 -1.4 -0.9
Vitamin and mineral supplements 0.7 1.0 1.6 -1.2 -0.7 -1.1 0.8 1.3 -1.2 0.5
Supplements: Zinc 0.2 0.2 0.4 0.4 -0.5 0.3 -0.7 0.5 -0.3 -0.6
Medication: Co-codamol 0.5 0.5 2.0 0.4 0.1 0.5 1.4 0.8 0.4 0.7
Medication: Metformin 1.2 1.8 2.4 -1.2 -1.5 -1.4 1.3 0.1 -1.6 -1.5
Diabetes (father) 1.3 1.7 5.0 -1.0 -0.9 -1.4 2.2 -0.7 -1.6 -0.2
Diabetes (mother) 2.2 2.8 7.6 1.6 1.5 1.6 1.2 2.8 1.2 1.5
Severe depression (siblings) 0.6 0.7 2.3 -1.5 0.1 -0.8 1.4 0.1 -0.3 -0.3
Pack years adult smoking proportion 0.3 0.4 1.7 -0.6 0.0 -0.3 1.3 0.3 -0.2 -0.7
Impedance of leg (right) 0.2 1.0 2.3 1.2 1.5 1.0 -0.1 -0.8 1.1 0.3
Leg fat-free mass (left) 0.3 1.7 3.3 -1.5 -1.8 -1.5 0.1 0.2 -1.4 -1.4
Trunk fat percentage 0.2 0.8 1.3 0.2 -0.8 -1.0 0.9 0.8 -1.0 1.1
Hand grip strength (right) 0.7 2.0 4.3 1.4 1.6 1.7 -1.2 0.2 2.1 0.7
Townsend deprivation index at recruitment 0.4 0.6 1.4 0.9 0.4 1.2 -0.9 0.2 1.1 0.1
Current tobacco smoking 1.3 2.1 3.7 1.9 1.6 1.9 -0.9 1.1 1.3 1.1
Average weekly fortified wine intake 0.6 0.6 1.6 1.3 0.9 0.8 0.3 -0.4 0.7 -0.9
Maternal smoking around birth 0.8 1.2 3.2 0.9 0.6 0.1 0.9 1.7 0.4 1.8
Fed-up feelings 0.6 1.2 3.0 0.8 1.3 1.1 0.3 0.7 1.1 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.3 -0.5 -0.4 -0.3 0.3 0.2 -0.4 0.4
Relative age voice broke 0.4 0.6 0.9 -0.7 -0.8 -0.9 0.8 0.9 -0.9 0.4
Taking other prescription medications 1.4 2.2 5.5 -0.7 -1.9 -1.1 2.3 -1.2 -1.1 -1.4
Age when periods started (menarche) 0.2 0.5 1.4 0.8 -0.3 -0.4 -1.1 0.2 0.4 -1.2
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 8.0 0.4 0.9 0.8 -2.8 -1.0 0.9 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.6 1.5 -0.2 -1.2 -0.6 1.2 -0.3 -0.6 -0.2
Tinnitus: Yes, but not now, but have in the past 1.1 1.1 2.9 0.1 -0.9 -0.1 1.0 -1.7 -0.6 1.7
Qualifications: CSEs or equivalent 0.5 0.7 1.8 -1.1 -0.1 -0.3 0.6 -1.2 0.1 -1.4
Serious illness, injury or assault to yourself 0.6 0.8 3.0 -0.7 -0.4 -0.9 1.7 -0.1 -0.8 -0.6
High blood pressure 0.3 0.9 1.9 1.0 0.2 0.9 1.4 -1.3 0.6 0.1
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.7 -0.3 -0.5 -0.2 0.9 -0.0 -0.3 -1.3
Multivitamins +/- minerals 1.1 1.4 2.5 1.6 0.9 1.5 -0.7 -1.2 1.6 0.2
Stomach or abdominal pain in last month 2.7 3.3 11.9 0.4 1.4 0.5 1.4 2.3 1.3 3.5
Supplements: Glucosamine 0.8 1.0 3.3 1.8 0.8 1.0 1.0 0.4 1.0 0.0
Diverticular disease/diverticulitis (self-reported) 3.4 4.0 9.4 -2.2 -1.8 -2.2 3.1 0.5 -2.3 -0.1
Medication: Atenolol 0.1 0.1 0.6 0.7 -0.1 0.5 -0.1 0.1 0.2 -0.1
Medication: Levothyroxine sodium 3.0 5.1 6.8 2.5 2.4 2.3 1.1 2.2 2.6 2.3
Sitting height 0.5 3.2 8.6 -1.3 -2.1 -1.7 -0.8 -1.7 -1.2 -2.9
Chronic bronchitis/emphysema (father) 0.9 1.1 3.6 1.0 1.0 0.6 -0.3 1.2 0.4 1.9
High blood pressure (mother) 0.1 0.2 0.7 -0.5 0.2 0.3 -0.2 -0.8 0.2 -0.2
Body mass index (BMI) 0.4 1.7 2.6 -1.0 -1.4 -1.6 1.6 1.0 -1.6 0.6
Impedance of leg (left) 0.3 1.4 2.9 1.6 1.7 1.1 -0.4 -0.7 1.3 0.8
Leg predicted mass (left) 0.3 1.7 3.4 -1.5 -1.8 -1.4 0.0 0.2 -1.4 -1.4
Trunk fat mass 0.3 1.2 2.7 -0.5 -1.5 -1.6 0.9 0.4 -1.5 0.3
Waist circumference 0.4 1.6 3.1 -0.9 -1.8 -1.6 1.2 0.6 -1.7 0.5
Number of incorrect matches in round 0.8 1.3 2.6 -1.6 -1.1 -1.5 0.2 0.7 -1.6 -0.6
Past tobacco smoking 1.0 1.8 4.4 1.2 2.1 1.5 0.5 0.8 1.7 0.6
Alcohol usually taken with meals 0.1 0.2 0.4 -0.5 -0.5 -0.1 0.2 0.6 -0.4 -0.2
Nervous feelings 0.6 1.1 5.3 -0.4 0.3 0.3 1.3 0.8 0.1 2.3
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.7 -0.6 0.5 0.0 1.1 1.4 0.1 1.6
Hearing difficulty/problems with background noise 0.5 0.9 1.9 1.2 0.6 1.4 1.0 0.5 0.6 0.9
Hair/balding pattern: Pattern 2 0.4 0.5 2.5 -0.3 0.7 0.3 1.6 -0.2 0.2 0.7
Had menopause 0.2 0.3 1.1 0.9 -0.0 -0.1 0.1 1.1 0.2 -0.4
Had other major operations 0.6 0.7 2.7 1.6 -0.1 0.3 -0.9 -0.9 0.8 0.1
Forced vital capacity (FVC) 0.1 0.3 1.0 -0.7 -0.1 -0.8 -1.0 0.5 -0.4 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.5 -0.4 -1.2 -0.9 1.0 -0.4 -0.6 -0.2
Ever unenthusiastic/disinterested for a whole week 1.3 1.5 5.5 1.3 0.5 1.1 1.1 0.3 0.8 2.3
Qualifications: None of the above 0.2 0.4 1.0 -0.6 -0.7 -0.6 0.6 -0.5 -1.0 -0.1
Financial difficulties in last 2 years 0.4 0.5 2.2 0.0 0.4 0.6 -1.5 0.3 0.5 0.8
Mouth/teeth dental problems 1.9 2.9 7.0 -1.1 -1.7 -1.5 -1.3 -2.6 -1.0 -2.1
Heart attack 1.9 2.4 4.6 2.1 1.3 1.9 -1.0 2.0 1.4 0.6
Allergy 0.3 0.8 2.4 1.1 0.9 0.5 -1.5 -0.2 0.6 0.5
Pain all over the body in last month 0.1 0.1 0.1 0.3 0.2 0.2 -0.2 0.3 0.3 -0.1
Diabetes (self-reported) 0.6 0.9 1.7 -0.8 -1.0 -1.3 0.9 0.6 -1.2 -0.8
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.5 -1.1 -0.7 -0.8 0.6 0.7 -0.4 -1.6
Medication: Ramipril 0.2 0.3 1.6 1.3 -0.3 0.6 -0.1 -0.1 0.3 0.2
Medication: Simvastatin 0.4 0.6 2.7 0.4 0.1 0.9 1.6 -0.6 0.5 0.2
Fluid intelligence score 0.7 1.6 3.4 1.8 1.0 1.4 -0.9 -0.9 1.7 0.1
Illnesses of siblings 1.3 1.8 3.1 1.4 1.5 1.3 -0.9 0.5 1.5 1.8
Neuroticism score 0.6 1.2 4.0 0.0 0.8 0.3 0.8 1.7 0.7 2.0
Weight 0.4 1.7 3.6 -1.2 -1.9 -1.9 0.6 0.1 -1.6 -0.7
Impedance of arm (right) 0.4 2.1 5.6 1.7 1.2 1.4 -2.4 -0.7 1.4 0.2
Arm fat percentage (right) 0.3 1.1 2.0 -0.5 -1.3 -1.3 0.8 1.0 -1.4 0.8
Trunk fat-free mass 0.7 3.9 8.9 -2.2 -2.4 -2.1 0.0 -0.5 -1.9 -3.0
Hip circumference 0.1 0.6 1.4 -0.5 -1.1 -1.2 0.1 0.2 -1.0 0.5
Time employed in main current job 0.5 0.6 1.3 -0.8 -0.8 -0.8 1.1 0.4 -0.8 -0.5
Alcohol intake versus 10 years previously 0.3 0.5 0.9 0.9 0.5 0.6 0.5 0.7 0.4 1.0
Father’s age at death 1.3 1.7 3.8 -1.8 -1.6 -1.5 0.3 -0.0 -1.9 -0.1
Worrier / anxious feelings 0.2 0.4 0.7 -0.8 -0.7 -0.7 0.3 0.1 -0.8 -0.1
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 3.0 1.1 1.3 1.4 -1.2 0.6 1.3 1.7
Falls in the last year 1.0 1.3 3.3 0.9 1.1 0.9 1.0 1.2 0.9 1.8
Hair/balding pattern: Pattern 3 0.2 0.3 0.7 0.7 0.3 0.1 -0.7 0.2 0.5 0.8
Number of live births 0.3 0.4 2.2 0.7 -0.2 0.4 -1.5 -0.1 0.2 0.3
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 2.7 -1.6 -0.7 -1.6 0.6 0.6 -1.2 -0.5
Pulse rate 0.8 1.3 2.2 -1.4 -1.5 -1.1 -0.4 0.1 -1.3 -1.4
Happiness 0.3 0.3 0.7 0.7 0.6 0.8 -0.1 0.1 0.6 0.7
Noisy workplace 1.2 1.5 2.9 -1.4 -1.7 -1.0 1.3 0.7 -1.5 0.4
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.7 -0.9 -0.4 -0.6 -0.1 -1.6 -0.1 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.6 -0.4 -0.4 -0.8 -0.8 -0.6 -0.6 0.8
Mouth/teeth dental problems: Dentures 1.1 1.9 7.4 0.3 0.5 0.1 1.7 2.7 -0.3 1.5
Asthma 0.4 0.7 1.8 -0.9 -0.9 -0.4 1.3 -0.4 -0.8 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.9 0.1 -0.4 -0.2 -1.0 -0.1 -0.1 -0.1
Medication: Cholesterol lowering 1.3 2.1 4.4 2.0 1.3 2.1 0.7 -0.7 1.8 0.1
Depression (self-reported) 2.6 3.1 6.3 -2.0 -1.9 -1.6 2.5 0.6 -2.2 -0.3
Medication: Lansoprazole 0.5 0.5 1.2 -0.4 -1.0 -0.6 0.4 -0.5 -1.1 0.8
Prospective memory result 0.3 0.3 1.3 0.3 0.4 0.0 -0.4 0.7 0.2 1.1
Lung cancer (father) 1.3 1.5 4.5 -0.6 -1.2 -1.7 2.1 0.9 -0.9 -0.2
Illnesses of mother 0.1 0.1 0.4 -0.1 0.0 -0.6 0.1 -0.2 -0.2 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.1 -1.1 -0.2 -0.8 0.6 0.0 -0.6 -0.2
Pulse wave Arterial Stiffness index 0.9 1.0 1.8 -1.4 -1.1 -1.0 0.6 -0.7 -1.1 -0.9
Impedance of arm (left) 0.5 2.4 4.9 1.9 1.5 1.5 -2.2 -0.1 1.6 0.9
Arm fat mass (right) 0.3 1.4 2.7 -0.7 -1.7 -1.6 0.9 0.7 -1.6 0.5
Trunk predicted mass 0.6 3.6 8.0 -2.1 -2.3 -2.0 0.0 -0.5 -1.8 -2.8
Standing height 0.3 2.9 7.6 -0.7 -1.4 -0.8 -2.3 -2.1 -0.4 -2.8
Length of working week for main job 1.0 1.2 6.2 0.6 1.0 0.6 0.2 2.5 0.1 0.4
Exposure to tobacco smoke at home 0.5 0.5 1.0 0.7 0.6 1.0 -0.1 0.8 1.0 0.6
Breastfed as a baby 0.1 0.2 0.5 0.1 -0.1 0.2 -0.7 0.2 0.4 -0.6
Tense / ‘highly strung’ 0.4 0.7 1.8 0.9 0.8 0.6 -0.1 0.2 1.0 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.1 -0.2 -0.8 0.0 1.0 0.4 -0.6 1.0
Hair/balding pattern: Pattern 4 1.0 2.4 5.8 1.7 1.2 1.7 -0.3 2.4 1.2 1.5
Birth weight of first child 0.1 0.2 0.4 -0.1 -0.6 -0.5 0.5 -0.2 -0.5 0.0
Peak expiratory flow (PEF) 0.5 1.1 2.8 -1.7 -0.2 -1.5 0.7 1.0 -0.7 -0.9
Pulse wave reflection index 0.4 0.5 2.0 0.3 0.8 0.6 -0.1 -0.0 0.4 1.4
Ever highly irritable/argumentative for 2 days 1.7 2.0 7.8 0.9 0.6 1.0 0.8 1.8 0.5 2.8
Loud music exposure frequency 0.0 0.1 0.1 0.3 0.2 0.3 0.3 0.3 0.1 0.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.1 -0.7 -0.3 -0.6 -0.6 -1.1 0.0 -0.9
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 4.7 0.1 0.6 1.0 1.2 2.2 0.5 0.4
Blood clot in the leg (DVT) 1.5 1.9 2.9 1.4 1.3 1.6 0.4 1.3 1.7 1.6
Medication: Paracetamol 0.3 0.6 1.3 -0.9 -0.9 -0.9 0.1 -0.4 -1.1 -0.3
Headache pain in last month 0.1 0.2 1.1 -0.5 0.2 -0.1 1.0 -0.2 -0.2 0.1
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 3.2 -1.8 -0.7 -1.5 -0.2 1.5 -1.5 0.2
Glaucoma (self-reported) 0.7 0.8 2.4 0.9 0.9 1.6 -0.5 0.5 1.1 -0.3
Gout (self-reported) 0.5 0.6 1.8 -0.1 -1.2 -0.5 0.1 -1.4 -0.5 0.8
Hypothyroidism/myxoedema (self-reported) 3.2 6.3 9.8 2.9 3.0 2.9 0.7 1.5 3.1 2.5
Medication: Amlodipine 0.5 0.7 2.2 0.3 0.2 0.8 1.5 -0.1 0.3 1.5
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.4 -0.0 0.1 0.3 -0.5 0.2 0.1 0.7
Birth weight 0.2 0.4 1.4 -0.5 -1.2 -0.3 -0.4 0.1 -0.7 0.4
Chronic bronchitis/emphysema (mother) 1.2 1.4 4.1 -0.6 -1.5 -0.6 2.0 1.1 -1.3 -0.0
High blood pressure (siblings) 3.5 5.0 7.2 -2.4 -2.5 -2.7 1.3 -0.8 -2.7 -2.5
Forced vital capacity (FVC), Best measure 0.0 0.1 0.6 -0.2 0.2 -0.0 -0.8 -0.2 0.1 0.3
Body fat percentage 0.3 1.1 2.0 -0.3 -1.1 -1.4 1.1 0.5 -1.4 1.0
Leg fat percentage (right) 0.5 1.8 4.2 -0.8 -1.3 -1.6 2.0 0.5 -1.7 0.7
Arm fat-free mass (right) 0.4 1.9 3.1 -1.6 -1.7 -1.8 0.4 0.1 -1.6 -1.4
Exposure to tobacco smoke outside home 0.2 0.2 0.7 -0.1 -0.6 -0.4 -0.8 -0.0 -0.4 0.4
Comparative body size at age 10 0.5 1.4 2.5 1.1 0.4 1.6 -1.5 -1.3 0.8 1.1
Number of full brothers 0.4 0.5 1.2 0.9 0.7 1.1 -0.2 0.3 0.8 0.0
Worry too long after embarrassment 0.9 1.5 4.4 -0.2 0.7 -0.4 1.5 1.8 0.2 2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 2.1 -0.5 -1.0 0.3 0.5 1.5 -0.8 0.2
Wheeze or whistling in the chest in last year 0.4 0.7 2.3 0.6 0.4 0.5 1.5 0.3 0.5 1.1
Number of children fathered 1.2 1.3 3.6 -0.9 -1.6 -1.4 -0.1 0.3 -1.9 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 2.6 0.6 1.6 0.8 -0.9 1.3 1.1 0.1
Age at first live birth 0.2 0.3 0.8 0.9 0.3 0.4 0.5 -0.4 0.6 0.4
Pulse wave peak to peak time 1.1 1.3 2.4 1.6 1.2 1.2 -1.0 0.4 1.4 0.8
Health satisfaction 0.9 1.1 4.5 0.6 0.0 0.4 1.2 2.1 -0.3 1.2
Shortness of breath walking on level ground 1.2 1.5 3.4 -0.9 0.1 -0.7 1.6 1.6 -0.8 1.9
Qualifications: College or University degree 0.2 0.7 2.5 0.4 0.6 0.7 0.6 -1.6 1.1 0.3
Eye problems/disorders: None of the above 0.4 0.4 0.8 -0.9 -0.2 -0.1 -0.8 -0.7 -0.3 -0.9
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.8 0.2 0.1 0.9 -0.4 -0.9 0.5 -0.2
Emphysema/chronic bronchitis 0.5 0.6 1.3 -1.2 -1.1 -0.7 0.2 0.4 -0.7 -0.4
Medication for pain relief, constipation, heartburn 0.2 0.4 1.5 0.3 0.6 0.4 -1.2 0.1 0.6 0.5
Neck or shoulder pain in last month 0.5 0.7 2.7 -0.1 -0.4 -0.5 -1.2 -1.7 0.1 -0.5
Medication: Blood pressure 0.6 1.0 3.6 0.6 -0.9 -0.1 -0.4 -1.9 -0.0 -1.5
Angina (self-reported) 0.8 1.1 3.5 -0.6 -0.6 -0.6 1.9 -1.5 -0.1 -1.0
Migraine (self-reported) 0.9 1.1 2.4 -1.2 -0.5 -1.5 1.6 -0.1 -1.2 -0.5
Medication: Ibuprofen 0.1 0.1 0.4 0.2 -0.1 -0.2 -0.6 -0.3 0.1 -0.2
Medication: Allopurinol 0.3 0.4 1.1 -0.6 -0.9 -0.7 0.2 -1.1 -0.4 0.1
Medication: Omeprazole 0.6 0.7 2.7 0.6 0.1 0.3 1.6 0.7 0.1 1.1
Medication: Seretide 50 evohaler 0.3 0.3 0.9 -0.5 -0.9 -0.3 0.7 -0.2 -0.8 0.3
Mean time to correctly identify matches 0.5 0.9 4.3 -0.2 -0.6 -0.3 0.6 2.1 -0.8 0.7
Heart disease (mother) 2.0 2.5 5.3 -2.1 -1.6 -1.5 0.7 -0.7 -1.3 -2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 2.3 -1.5 -1.1 -1.3 1.4 1.1 -1.1 -0.8
Whole body fat mass 0.3 1.3 2.7 -0.6 -1.6 -1.6 1.0 0.4 -1.5 0.3
Leg fat mass (right) 0.4 1.4 2.5 -0.9 -1.5 -1.6 1.4 0.3 -1.5 0.4
Arm predicted mass (right) 0.4 2.1 3.3 -1.6 -1.8 -1.8 0.5 0.2 -1.7 -1.5
Pulse rate, automated reading 0.7 2.4 5.1 -2.3 -1.5 -2.0 0.3 0.5 -1.9 -1.2
Alcohol intake frequency. 0.3 0.8 2.4 -0.3 0.3 -0.4 1.5 1.3 -0.3 0.8
Comparative height size at age 10 0.4 2.4 6.0 0.2 -1.4 0.1 -2.3 -1.7 -0.4 -2.5
Number of full sisters 0.4 0.5 0.9 -0.9 -0.4 -0.9 0.8 -0.2 -1.0 -0.1
Suffer from ‘nerves’ 1.5 2.4 4.4 -2.1 -1.1 -1.4 1.9 0.5 -1.7 1.6
Overall health rating 0.1 0.2 0.9 -0.2 -0.5 -0.1 -0.3 0.9 -0.4 0.4
Chest pain or discomfort 1.0 1.5 2.4 0.9 1.5 1.4 1.0 -0.4 1.6 1.2
Had major operations 0.8 0.9 6.0 0.0 -0.0 -0.1 2.4 -0.4 0.0 -0.1
Age at last live birth 0.5 0.7 1.7 0.8 0.2 1.1 1.1 -1.3 0.6 -0.2
Family relationship satisfaction 0.2 0.3 0.8 0.2 0.1 0.7 -0.9 -0.7 0.4 0.1
Leg pain on walking 0.7 0.9 2.9 -0.0 -0.7 -0.3 0.5 1.7 -0.6 1.5
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 2.2 -1.1 -0.5 -0.8 1.5 1.2 -1.1 0.0
Commuting to job workplace: Car/motor vehicle 0.8 0.9 3.4 0.2 0.4 0.6 1.8 0.1 0.5 1.6
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.9 0.7 -0.2 0.7 -0.9 -1.0 0.2 -0.1
Medication: Aspirin 1.0 1.3 5.1 -0.4 -0.5 -0.4 2.2 -1.2 -0.4 -1.4
Supplements: Vitamin C 0.3 0.4 1.1 1.0 1.0 0.4 -0.4 0.1 0.7 0.1
Knee pain experienced in last month 0.1 0.2 0.9 -0.3 0.2 -0.3 -0.2 0.9 -0.0 0.2
Hypertension (Self-reported) 0.3 0.7 2.0 1.0 -0.0 0.6 1.3 -1.4 0.4 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.0 0.9 0.6 0.6 0.6 0.1 0.6 1.0
Illnesses of father: Heart disease 1.2 1.6 4.4 -1.3 -1.3 -1.0 -0.0 -1.2 -0.9 -2.1
Illnesses of siblings: Diabetes 0.8 0.9 1.8 0.9 1.3 1.3 -0.9 0.8 0.9 -0.2
Smoking status: Previous 2.0 3.0 5.8 -1.8 -2.4 -2.0 -0.8 -1.7 -1.9 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.9 0.7 0.7 0.3 -1.4 -1.1 1.0 0.4
Whole body fat-free mass 0.6 3.2 5.5 -2.0 -2.3 -2.0 0.1 -0.2 -1.8 -2.4
Leg fat-free mass (right) 0.2 1.2 2.8 -1.3 -1.7 -1.3 -0.2 0.2 -1.1 -1.1
Arm fat percentage (left) 0.3 1.2 1.8 -0.3 -1.2 -1.2 0.9 1.2 -1.4 1.2
Average weekly red wine intake 1.5 2.2 4.7 -1.3 -1.3 -0.7 -1.9 -1.6 -1.0 -2.2
Handedness (chirality/laterality): Left-handed 1.0 1.2 4.4 0.4 1.0 -0.0 -0.9 -2.1 1.3 -0.2
Mood swings 0.6 1.1 4.2 -0.3 0.8 0.0 0.7 1.4 0.5 2.0
Loneliness, isolation 1.6 2.2 4.6 1.3 1.5 1.4 0.4 1.8 1.2 2.1
Long-standing illness, disability or infirmity 0.2 0.3 1.0 -0.2 -1.0 -0.6 0.7 0.0 -0.7 -0.1
Ever had bowel cancer screening 3.2 3.7 5.3 -2.3 -2.3 -2.0 1.2 -0.9 -2.3 -2.1
Diabetes diagnosed by doctor 0.5 0.8 1.5 -0.8 -1.1 -1.2 0.6 0.2 -1.2 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 4.7 0.1 0.5 0.4 -2.2 -0.1 0.5 -1.5
Friendships satisfaction 0.7 0.9 4.5 0.4 0.1 1.0 -2.1 -0.7 0.4 0.3
Qualifications: nursing, teaching 1.2 1.9 4.5 1.5 1.9 1.7 -0.2 0.1 2.1 -0.0
Commuting to job workplace: Walk 0.1 0.1 0.5 0.4 0.2 -0.1 -0.7 0.2 0.1 0.2
Eye problems/disorders: Cataract 1.3 1.5 3.1 1.8 1.4 0.7 -1.3 -0.4 1.3 1.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.7 -0.1 0.6 -0.1 1.3 0.1 0.2 0.3
Medication for cholesterol 0.5 0.8 4.4 0.0 0.5 0.2 -2.1 -0.4 0.3 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 1.7 1.0 1.3 0.5 0.8 0.1 1.2 1.1
Back pain experienced in last month 0.2 0.3 1.2 0.6 -0.3 0.5 0.3 -1.1 0.2 -0.5
Mineral and other dietary supplements 1.1 1.5 2.9 -1.7 -0.6 -1.5 0.6 1.1 -1.3 1.3
Breast cancer (self-reported) 0.2 0.2 0.4 0.1 -0.5 -0.3 0.5 -0.5 -0.2 0.6
Asthma (self-reported) 0.4 0.8 2.6 -0.9 -0.8 -0.5 1.6 -0.3 -0.7 0.7
Osteoporosis (self-reported) 0.1 0.1 0.3 -0.4 0.2 -0.3 0.6 -0.2 -0.2 -0.6
Osteoarthritis (self-reported) 0.1 0.1 0.5 -0.1 -0.2 -0.1 -0.2 -0.6 -0.2 0.7
Medication: Aspirin 0.9 1.2 4.8 -0.4 -0.6 -0.6 2.2 -0.9 -0.7 -1.1
Medication: Gliclazide 0.2 0.2 0.5 -0.5 -0.3 -0.6 0.4 0.1 -0.6 -0.7
Illnesses of father: None of the above (group 1) 0.1 0.1 0.4 -0.1 -0.3 -0.1 -0.6 -0.3 0.0 -0.5
Smoking status: Current 0.9 1.4 2.4 1.5 1.2 1.4 -0.9 1.2 1.0 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.4 -0.6 0.0 -0.5 1.2 0.9 -0.4 0.3
Whole body water mass 0.5 2.8 4.8 -1.9 -2.2 -1.9 0.0 -0.2 -1.7 -2.1
Leg predicted mass (right) 0.3 1.4 3.0 -1.4 -1.7 -1.3 -0.1 0.2 -1.2 -1.2
Arm fat mass (left) 0.4 1.6 3.1 -0.7 -1.8 -1.7 0.8 0.8 -1.7 0.5
Number of self-reported non-cancer illnesses 0.6 1.1 4.6 0.0 -0.6 -0.0 2.1 -1.6 0.2 -0.1
Average weekly champagne plus white wine intake 0.9 1.2 4.5 0.4 1.2 0.9 -2.1 0.5 1.2 -0.3
Miserableness 0.1 0.1 0.8 -0.3 0.2 -0.0 -0.0 0.2 0.1 0.9
Guilty feelings 0.5 0.7 2.9 0.4 1.0 0.4 0.5 0.2 0.8 1.7
Wears glasses or contact lenses 0.2 0.2 1.0 1.0 -0.3 0.0 0.4 0.4 -0.1 0.2
Ever taken oral contraceptive pill 0.5 0.6 1.9 -1.0 -0.8 -1.4 0.0 0.2 -0.5 0.4
Hearing aid user 0.9 1.0 1.9 1.4 1.2 0.8 0.7 0.9 1.1 1.0
Mother’s age at death 0.3 0.3 1.2 0.5 0.2 0.4 -1.1 -0.3 0.3 0.7
Financial situation satisfaction 0.5 0.6 1.8 0.9 0.5 0.8 -0.2 0.7 0.4 1.4
Tinnitus: Yes, now most or all of the time 1.9 2.3 4.0 -1.1 -1.9 -1.7 -0.2 -2.0 -1.4 -1.5
Commuting to job workplace: Public transport 0.3 0.4 1.7 0.0 -0.1 0.6 0.6 -0.4 0.2 -1.3
Eye problems/disorders: Glaucoma 0.4 0.4 0.8 0.7 0.8 0.8 -0.4 0.2 0.9 -0.7
Medication: Blood pressure 0.9 1.7 9.7 0.5 0.0 0.1 3.1 0.7 -0.1 1.1
Pain type(s) experienced in last month: Hip pain 1.1 1.3 5.7 0.9 0.4 0.5 -1.0 1.0 0.6 2.4
Supplements: Fish oil (including cod liver oil) 2.1 2.7 5.6 2.4 1.6 2.2 -0.8 -1.1 2.1 -0.2
High cholesterol (Self-reported) 0.5 0.8 3.4 0.7 0.3 1.0 1.8 -0.3 0.8 -0.0
Medication: Bendroflumethiazide 1.7 2.6 5.6 -1.6 -1.8 -1.2 2.4 -0.4 -1.8 -1.6
Medication: Paracetamol 0.2 0.3 1.0 -0.6 -0.6 -0.7 0.3 -0.3 -1.0 -0.1
Medication: Lisinopril 0.4 0.5 2.9 0.5 -0.6 0.2 1.7 0.0 -0.2 0.2
Medication: Atorvastatin 0.6 0.8 1.7 -0.8 -0.6 -0.6 1.2 0.3 -0.8 -1.3
Illnesses of father: High blood pressure 0.7 0.8 1.3 -0.9 -0.8 -1.2 1.2 -0.7 -1.1 -0.0
Alcohol drinker status: Never 0.4 0.5 2.2 0.2 0.7 0.2 0.6 1.5 0.0 0.1
Ever smoked 0.8 1.4 3.0 -0.7 -1.7 -0.6 -0.9 -1.3 -1.5 -1.2
Basal metabolic rate 0.5 2.7 4.9 -1.8 -2.2 -2.0 0.3 -0.0 -1.8 -1.8
Leg fat percentage (left) 0.4 1.6 3.2 -0.5 -1.2 -1.6 1.8 0.5 -1.5 1.0
Arm fat-free mass (left) 0.4 2.1 4.0 -1.6 -2.0 -1.7 0.3 -0.0 -1.7 -1.5
Number of operations (self-reported) 0.3 0.4 1.2 1.1 0.5 0.0 0.3 -0.7 1.0 -0.1
Average weekly beer plus cider intake 0.2 0.2 0.9 -0.3 -0.0 -0.1 0.9 -0.1 -0.3 0.6
Irritability 1.6 2.8 6.6 1.6 1.2 1.1 -2.6 0.6 1.2 2.4
Risk taking 0.6 0.9 2.3 -1.0 -0.4 -1.0 0.8 -1.5 -0.9 -0.8
Ever had prostate specific antigen (PSA) test 2.5 2.9 5.0 -1.6 -2.0 -1.6 0.0 -2.2 -1.6 -1.9
Fractured/broken bones in last 5 years 2.9 3.7 7.7 1.9 1.7 2.1 1.4 -2.8 2.1 0.8
Age started oral contraceptive pill 0.3 0.4 1.2 -0.7 -0.1 -0.7 0.5 0.3 -0.1 -1.1
Diastolic blood pressure, automated reading 0.0 0.1 0.2 0.3 0.1 -0.0 -0.5 0.0 0.4 0.3
Ever depressed for a whole week 0.8 0.9 4.0 0.7 0.1 -0.1 1.3 0.5 0.4 2.0
Unable to work because of sickness or disability 0.2 0.3 1.0 0.3 -0.2 0.0 1.0 -0.6 0.1 -0.5
Commuting to job workplace: Cycle 2.9 3.5 6.3 -2.1 -1.7 -2.1 1.4 -1.0 -1.8 -2.5
Myopia 1.5 2.1 5.9 -1.3 -1.4 -0.8 1.4 -1.3 -1.0 -2.4
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.4 -1.4 -0.5 -1.2 -1.5 1.5 -1.0 0.3
Cholesterol lowering medication 1.7 2.5 4.1 -1.9 -1.8 -1.8 2.0 -0.1 -1.9 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.6 0.7 0.2 0.1 1.6 1.3 0.0 1.0
Pain experienced in last month 0.1 0.1 0.3 0.2 -0.5 -0.0 0.2 -0.5 -0.4 0.1
Supplements: Calcium 0.8 0.9 1.9 -1.2 -1.1 -0.7 0.1 -0.4 -0.8 -1.4
Basal cell carcinoma (self-reported) 0.8 1.0 3.0 1.0 0.2 1.2 -0.7 -1.7 0.5 0.6
Heart attack/myocardial infarction (self-reported) 2.7 3.4 6.9 2.6 1.6 2.3 -1.4 1.9 1.7 0.8
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 3.6 1.5 1.5 1.7 0.5 1.3 1.8 1.9
Heart disease (siblings) 0.2 0.2 1.2 -0.3 0.2 0.2 1.1 0.2 0.2 0.4
Alcohol drinker status: Previous 0.5 0.5 2.0 -0.2 0.9 0.5 0.6 1.4 0.4 0.2
Pack years of smoking 0.2 0.3 1.4 -0.6 -0.1 -0.4 1.2 0.2 -0.2 -0.7
Impedance of whole body 0.5 2.6 4.8 2.2 1.9 1.7 -1.7 -0.5 1.7 1.2
Leg fat mass (left) 0.4 1.5 2.7 -0.8 -1.5 -1.7 1.4 0.3 -1.5 0.5
Arm predicted mass (left) 0.4 1.9 3.3 -1.5 -1.8 -1.7 0.4 -0.1 -1.5 -1.5