TWAS hub - HK1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0706	0.0254	0.00190	0.016	0.010	0.012	0.015	0.015	1.5e-03	8.9e-03	6.2e-03	0.0023	0.00180
2	YFS	Blood	0.0256	0.0123	0.01500	0.010	0.003	0.019	0.007	0.014	1.9e-04	2.0e-02	6.5e-07	0.0012	0.00002
3	TCGA	Breast Invasive Carcinoma	0.0393	0.0137	0.00015	0.022	0.018	0.011	NA	0.016	2.1e-05	8.7e-05	1.7e-03	NA	0.00028
4	TCGA	Brain Lower Grade Glioma	0.0404	0.0194	0.00860	0.004	0.006	0.013	NA	0.008	1.1e-01	6.8e-02	9.8e-03	NA	0.03900

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
HbA1C	19.3	21.4	50.4	7.1	4.8	-3.4	0.5
Blood Red Count	5.7	55.2	163.8	-12.8	-5.0	5.7	0.0
Basal cell carcinoma (self-reported)	4.5	5.3	16.5	-0.6	4.1	-1.8	-1.1
Financial difficulties in last 2 years	4.1	5.5	12.1	-2.9	0.7	-3.5	-1.1
Birth weight of first child	4.1	7.4	17.1	4.1	2.7	-2.2	0.2
Heart attack/myocardial infarction (self-reported)	4.0	5.1	11.9	-3.5	-1.1	-0.6	-2.7
Heart attack	3.4	4.3	9.7	-3.1	-1.2	-0.2	-2.4
Body Mass Index (BMI) (2010)	2.6	3.5	4.7	1.9	2.1	1.2	2.2
Father’s age at death	2.6	3.4	7.3	-0.5	-2.5	2.7	-0.4
Average weekly champagne plus white wine intake	2.4	3.4	6.3	1.6	2.1	-0.4	2.5
Average weekly spirits intake	2.2	2.7	8.0	-1.3	-2.8	-0.4	-1.0
Had menopause	2.2	2.7	6.8	0.0	-2.6	1.6	-1.3
Pain all over the body in last month	2.2	2.3	6.3	-0.9	-2.5	1.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	7.4	-2.7	-2.2	-0.6	-1.4
Ever highly irritable/argumentative for 2 days	2.2	2.7	4.2	0.6	-1.8	2.0	1.7
Migraine (self-reported)	2.1	2.6	5.8	-0.1	1.2	-2.4	-1.8
Eye problems/disorders: Diabetes related eye disease	2.0	2.3	6.2	0.7	-2.5	1.4	-0.6
Ever taken oral contraceptive pill	2.0	2.2	2.9	-1.5	1.7	-1.5	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	4.2	-2.0	-0.5	-2.1	-1.8
Qualifications: CSEs or equivalent	1.8	2.4	6.9	-2.6	0.4	-1.5	0.6
Allergy	1.8	4.2	12.8	3.6	1.1	1.6	0.2
Falls in the last year	1.8	2.4	4.4	-2.1	-1.1	1.9	0.8
Medication: Allopurinol	1.8	2.4	4.0	-2.0	-1.9	0.2	-1.4
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	3.8	1.9	-0.5	2.0	0.9
Illnesses of siblings: Diabetes	1.8	2.2	7.2	-0.6	-2.7	0.5	-1.0
Osteoporosis (self-reported)	1.8	2.3	5.0	-0.5	-0.9	1.7	2.2
Type 2 Diabetes (T2D) (2012)	1.7	2.0	5.7	2.4	1.1	-0.5	0.9
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	5.8	0.2	-1.1	2.4	0.9
Ever had bowel cancer screening	1.7	1.9	4.1	-0.3	-2.0	0.0	-1.9
Alcohol drinker status: Never	1.7	2.0	4.6	1.6	0.4	2.1	0.8
Supplements: Calcium	1.7	1.9	3.0	-1.3	-1.1	1.3	1.7
Hayfever, allergic rhinitis or eczema	1.6	3.6	8.4	-2.9	-0.8	-2.3	0.1
Pulse wave Arterial Stiffness index	1.6	1.9	5.2	-0.4	-2.3	1.3	-0.6
Allergy or Eczema	1.5	3.9	9.5	-3.1	-0.9	-2.3	0.0
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.0	0.1	-2.0	1.8	-0.6
Supplements: Glucosamine	1.5	1.9	4.4	-1.5	-1.0	-0.3	-2.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	2.9	-1.7	-0.5	-1.4	-1.5
Guilty feelings	1.5	2.3	6.7	0.2	1.2	-2.6	-0.9
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	2.9	1.7	-1.1	1.6	-0.1
Mouth/teeth dental problems	1.4	2.2	4.3	2.0	2.1	0.0	-0.6
Headache pain in last month	1.4	2.4	5.4	-0.8	1.5	-1.1	-2.3
Pulse wave peak to peak time	1.4	1.7	4.8	0.5	2.2	-1.1	0.8
High cholesterol (Self-reported)	1.4	2.4	6.2	2.5	0.2	-1.7	-0.8
Time employed in main current job	1.3	1.5	3.4	1.9	0.7	1.2	-0.8
Happiness	1.3	1.5	6.2	0.0	0.1	0.0	-2.5
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	5.8	-2.4	-0.3	-0.8	-0.1
Knee pain experienced in last month	1.3	2.1	6.1	-2.5	-1.3	0.6	-0.6
Hypertension (Self-reported)	1.3	3.7	9.2	3.0	2.0	-0.4	-1.1
Commuting to job workplace: Public transport	1.3	1.6	2.6	-1.2	-0.1	-1.5	-1.6
Pain experienced in last month	1.3	2.2	4.2	2.1	1.8	0.7	0.8
Crohns Disease (2012)	1.2	2.0	3.3	1.8	-1.3	1.7	-0.2
Respiratory disease	1.2	2.6	8.1	-2.9	-1.4	-0.3	-0.3
Sensitivity / hurt feelings	1.2	2.0	4.3	-1.1	-1.1	-2.1	-1.1
High blood pressure	1.2	3.2	7.2	2.7	1.9	-0.7	-1.1
Hair/balding pattern: Pattern 4	1.2	2.8	4.7	-1.4	-1.3	-1.7	-2.2
Long-standing illness, disability or infirmity	1.2	1.8	5.4	-2.3	-1.3	0.3	0.4
Ovarian Cancer	1.1	1.4	5.2	-0.2	-2.3	0.6	-0.0
Cardiovascular Disease	1.1	3.7	10.9	3.3	1.5	-1.0	-0.8
Medication: Metformin	1.1	1.6	6.1	2.5	-0.2	-0.1	0.4
Relative age voice broke	1.1	1.8	6.1	-0.8	2.5	-0.5	-0.2
Qualifications: None of the above	1.1	2.3	4.5	2.1	-1.1	1.8	-0.6
Blood clot in the leg (DVT)	1.1	1.5	3.6	-0.6	-1.3	0.4	-1.9
Exposure to tobacco smoke outside home	1.1	1.5	4.2	-0.1	1.4	-0.2	-2.0
Chest pain or discomfort	1.1	1.6	2.8	-1.5	1.7	-1.1	-0.2
Handedness (chirality/laterality): Left-handed	1.1	1.4	3.5	1.9	-1.0	0.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.8	-2.0	0.9	0.4	0.0
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.0	-0.7	-1.4	0.5	-1.7
Alzheimer’s Disease (including proxy)	1.0	1.4	2.9	-1.7	-0.9	-0.8	1.2
Mean Putamen Volume	1.0	1.2	3.3	-0.4	-1.8	1.1	-0.1
LDL Cholesterol	1.0	1.6	4.8	2.2	1.2	0.5	0.1
Average weekly fortified wine intake	1.0	1.1	2.8	1.7	-0.6	1.1	0.1
Chronic bronchitis/emphysema (father)	1.0	1.1	1.5	-1.2	-1.2	-0.5	-1.2
Pulse wave reflection index	1.0	1.2	4.1	-0.8	-2.0	0.3	-0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.5	0.0	0.6	-1.6	-1.9
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.9	-1.0	-1.1	1.7	1.3
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.5	-1.1	0.7	-1.6	-0.8
Heart disease (mother)	1.0	1.2	2.9	-1.0	0.2	-1.7	-1.0
Pulse rate, automated reading	1.0	3.1	5.9	-2.1	-1.3	2.4	0.8
Osteoarthritis (self-reported)	1.0	1.3	1.9	-1.3	-1.4	1.2	0.3
Eye problems/disorders: Glaucoma	1.0	1.1	3.0	1.7	-0.2	1.0	0.7
Age started oral contraceptive pill	1.0	1.3	2.6	-1.6	-1.0	0.5	-1.1
Crohns Disease (2017)	0.9	2.0	5.0	0.7	-2.2	1.3	0.9
Mouth/teeth dental problems: Dentures	0.9	1.5	3.6	0.2	-1.1	1.9	1.2
Medication: Cholesterol lowering	0.9	1.4	2.9	0.7	1.3	-1.7	-0.7
Illnesses of mother	0.9	1.1	2.5	0.0	1.6	-0.1	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	4.6	2.1	2.1	0.7	1.5
Gout (self-reported)	0.9	1.2	2.7	-0.5	-1.6	1.3	-0.2
Eye problems/disorders: None of the above	0.9	1.0	1.3	-1.2	0.9	-0.9	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.9	-1.0	1.7	-0.7	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.9	1.0	-1.0	0.3	1.4
Mineral and other dietary supplements	0.9	1.2	2.0	1.2	1.4	0.1	1.1
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.3	-0.9	-1.8	-0.1	0.6
Commuting to job workplace: Cycle	0.9	1.0	3.1	-0.6	-0.7	0.5	1.7
Alzheimer’s Disease (in father)	0.8	0.8	1.1	-1.0	-1.0	-0.4	1.0
Major Depression (MDD)	0.8	0.9	2.6	0.6	1.6	-0.2	0.9
Chronotype (morning person)	0.8	1.9	3.1	-1.7	0.3	-1.2	-1.8
Vitamin and mineral supplements	0.8	1.1	1.6	0.8	-1.0	1.2	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.6	-1.0	-0.9	0.9	1.6
Illnesses of siblings	0.8	1.2	2.0	-0.8	1.4	-0.7	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.2	-0.3	-0.3	-0.5	-1.8
Peak expiratory flow (PEF)	0.8	1.9	4.7	1.4	2.2	0.6	0.8
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.0	-1.1	-1.7	-0.3	-1.3
Birth weight	0.8	1.8	3.7	1.9	-1.7	-0.0	-0.8
Worry too long after embarrassment	0.8	1.3	2.0	-0.9	-1.3	-1.4	-0.9
Medication: Seretide 50 evohaler	0.8	0.9	3.2	-0.3	1.8	-0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.6	-1.3	0.1	-0.9	-1.3
Eye problems/disorders: Cataract	0.8	0.9	2.2	0.3	-1.5	0.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.2	2.3	0.5	0.0	1.1
Financial situation satisfaction	0.8	1.0	3.3	-1.8	0.1	-0.8	-0.2
Medication: Bendroflumethiazide	0.8	1.2	3.2	-0.8	0.8	-1.8	-0.7
Medication: Atorvastatin	0.8	1.0	2.7	0.0	-0.2	-1.6	-1.1
Risk taking	0.8	1.2	3.9	-0.8	-2.0	-0.5	0.1
Heart disease (siblings)	0.8	0.9	2.1	-1.2	-1.4	-0.3	0.1
HDL Cholesterol	0.7	1.1	2.1	0.8	1.0	-1.5	-0.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.5	0.9	0.8	0.3	1.6
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	1.8	0.8	-0.6	1.0	1.3
Medication: Co-codamol	0.7	0.8	2.0	-1.4	-0.1	-0.2	-1.1
Severe depression (siblings)	0.7	0.8	1.9	-1.0	-1.4	0.3	-0.6
Current tobacco smoking	0.7	1.2	4.6	-0.0	-0.2	0.4	2.1
Maternal smoking around birth	0.7	1.0	1.9	-1.4	-1.4	0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.1	1.5	1.8	-0.7	0.9
Hearing difficulty/problems with background noise	0.7	1.1	3.4	-0.2	-0.8	-0.7	-1.9
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.7	0.4	1.6	-1.6	-1.1
Lung cancer (father)	0.7	0.8	1.8	-0.8	0.1	-1.0	-1.3
Loud music exposure frequency	0.7	0.8	1.7	-0.7	-0.3	-1.3	-0.9
High blood pressure (siblings)	0.7	1.0	2.2	1.2	-0.3	0.4	-1.5
Forced vital capacity (FVC), Best measure	0.7	2.6	5.2	2.3	1.8	0.4	1.4
Number of full brothers	0.7	0.9	2.8	-0.6	0.8	0.2	1.7
Overall health rating	0.7	1.5	4.3	-0.7	-2.1	1.0	0.0
Illnesses of father: None of the above (group 1)	0.7	0.8	1.2	1.1	0.9	0.9	0.6
Wears glasses or contact lenses	0.7	0.9	2.4	0.4	-0.9	0.3	-1.5
Medication: Blood pressure	0.7	1.4	3.4	1.8	1.5	-0.1	-0.0
Number of operations (self-reported)	0.7	1.0	2.8	-0.4	-1.0	1.7	-0.0
Fractured/broken bones in last 5 years	0.7	0.9	2.3	1.5	-0.1	1.1	0.1
Diastolic blood pressure, automated reading	0.7	2.1	2.9	1.1	1.5	-1.4	-1.7
Alcohol drinker status: Previous	0.7	0.8	1.3	1.2	0.9	0.9	-0.2
Relative age of first facial hair	0.6	1.2	2.7	-1.6	-1.2	0.4	-0.7
Trunk fat percentage	0.6	2.3	5.2	-2.3	-1.0	0.4	-1.7
Age when periods started (menarche)	0.6	1.5	3.2	-1.8	1.3	-0.3	0.9
Serious illness, injury or assault to yourself	0.6	0.8	2.2	-0.7	1.5	-0.2	-0.5
Multivitamins +/- minerals	0.6	0.8	1.5	0.3	0.6	-1.2	1.2
High blood pressure (mother)	0.6	0.8	2.7	1.7	-0.3	0.4	-0.7
Alcohol usually taken with meals	0.6	0.9	1.3	0.6	1.1	-0.9	-1.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.4	-0.5	0.1	-1.6	0.6
Medication: Ramipril	0.6	0.7	1.3	1.1	0.9	0.1	0.8
Fluid intelligence score	0.6	1.3	3.8	0.7	2.0	0.9	0.2
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	2.6	1.6	1.6	0.3	1.5
Asthma	0.6	1.2	3.0	-1.7	-1.1	0.8	0.2
Length of working week for main job	0.6	0.6	1.4	-0.0	1.0	-1.2	0.2
Breastfed as a baby	0.6	0.7	2.1	-0.7	-1.4	-0.0	-0.3
Medication: Paracetamol	0.6	0.9	1.8	-1.4	-1.3	-0.1	-0.6
Glaucoma (self-reported)	0.6	0.7	0.9	0.8	-0.5	0.9	1.0
Number of children fathered	0.6	0.7	1.7	-0.6	1.3	-0.7	0.1
Emphysema/chronic bronchitis	0.6	0.7	1.7	-1.3	-0.4	0.2	-0.9
Mean time to correctly identify matches	0.6	1.1	4.1	0.3	-0.3	2.0	0.5
Alcohol intake frequency.	0.6	1.3	2.2	1.3	-0.7	0.9	-1.5
Had major operations	0.6	0.7	1.7	0.2	-1.3	0.8	-0.5
Supplements: Vitamin C	0.6	0.8	1.5	-1.2	0.2	-1.2	-0.3
Back pain experienced in last month	0.6	0.9	1.2	-1.1	1.0	-1.0	0.4
Asthma (self-reported)	0.6	1.3	4.0	-2.0	-1.0	0.4	0.2
Miserableness	0.6	1.0	1.5	-1.2	-1.0	-0.8	-0.9
Medication: Lisinopril	0.6	0.8	1.9	1.0	-0.0	0.3	1.4
Ever depressed for a whole week	0.6	0.8	2.7	0.5	0.3	-0.3	-1.6
Schizophrenia vs Biploar Disorder	0.5	0.6	1.6	1.3	0.6	0.1	0.6
Reaction Time	0.5	1.0	3.4	-0.0	0.1	1.8	0.8
Prostate Cancer	0.5	0.7	1.6	-1.0	-1.3	0.3	-0.3
Age at First Birth	0.5	0.8	1.5	0.8	1.2	-0.9	0.2
Hypothyroidism (self reported)	0.5	1.3	2.8	-0.4	-1.4	-0.1	-1.7
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-0.1	-1.2	0.7	0.6
Townsend deprivation index at recruitment	0.5	0.8	1.0	0.9	-0.6	1.0	-1.0
Medication: Atenolol	0.5	0.6	2.4	0.1	1.6	0.1	-0.3
Had other major operations	0.5	0.7	2.3	-0.2	1.5	0.6	-0.1
Diabetes (self-reported)	0.5	0.8	1.5	1.2	-1.2	0.4	-0.4
Impedance of arm (right)	0.5	2.3	6.7	-2.6	-1.4	0.4	0.7
Alcohol intake versus 10 years previously	0.5	0.8	1.6	-0.8	-0.9	0.1	-1.3
Body fat percentage	0.5	2.0	4.1	-2.0	-0.8	0.3	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	1.2	0.1	0.1	1.0
Neck or shoulder pain in last month	0.5	0.8	2.3	-0.3	-1.5	-0.2	-0.8
Suffer from ‘nerves’	0.5	0.7	2.5	1.6	-0.5	0.4	-0.0
Medication for cholesterol	0.5	0.8	2.1	-1.1	-0.2	-0.0	1.4
Breast cancer (self-reported)	0.5	0.6	1.1	-1.0	-0.1	0.9	0.8
Smoking status: Current	0.5	0.8	2.8	-0.6	-0.4	0.1	1.7
Hearing aid user	0.5	0.6	1.7	0.6	0.3	1.3	-0.2
Mother’s age at death	0.5	0.6	1.6	1.3	0.4	0.2	0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.4	0.0	-1.1	0.1	-1.2
Medication: Paracetamol	0.5	0.7	1.4	-1.1	-1.2	0.4	0.1
Average weekly beer plus cider intake	0.5	0.7	1.4	-1.2	-0.0	0.3	1.1
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.7	-1.6	-1.3	0.7	1.1
Cholesterol lowering medication	0.5	0.7	1.5	0.7	-1.2	-0.1	-0.9
Verbal and Numeric Reasoning (VNR)	0.4	1.1	1.7	1.3	1.2	0.9	-0.7
Bipolar Disorder (2011)	0.4	0.3	1.4	1.2	0.0	0.0	0.0
Fasting Glucose	0.4	0.5	1.3	0.7	-0.5	1.2	-0.4
Triglycerides	0.4	0.6	1.4	0.0	0.3	1.2	1.0
Blood Platelet Count	0.4	4.5	13.3	3.6	2.2	0.2	-0.1
Lung FEV1/FVC ratio	0.4	2.0	4.0	2.0	1.2	0.8	1.4
Angina	0.4	0.5	1.1	-1.1	-0.9	0.4	0.0
Medication for hormone replacement therapy	0.4	0.5	0.8	0.3	0.6	0.9	-0.8
Past tobacco smoking	0.4	0.7	2.4	1.5	0.1	0.6	0.0
Medication: Simvastatin	0.4	0.6	1.5	1.2	-0.5	-0.6	-0.4
Neuroticism score	0.4	0.8	1.7	-0.3	-1.0	-1.3	-0.6
Arm fat percentage (right)	0.4	1.7	3.2	-1.8	-1.0	0.0	-1.6
Trunk fat-free mass	0.4	2.1	5.3	2.3	0.8	0.7	1.4
Pulse rate	0.4	0.7	1.1	0.4	1.0	0.7	1.1
Medication: Lansoprazole	0.4	0.4	0.6	-0.6	-0.7	0.3	0.8
Prospective memory result	0.4	0.4	1.7	-0.2	-1.3	0.2	0.2
Impedance of arm (left)	0.4	2.0	6.2	-2.5	-0.9	0.9	0.5
Trunk predicted mass	0.4	2.1	5.4	2.3	0.8	0.7	1.3
Medication: Amlodipine	0.4	0.6	1.1	0.5	0.7	-0.8	-1.1
Wheeze or whistling in the chest in last year	0.4	0.8	2.7	-1.6	-0.7	0.2	-0.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.4	-1.2	0.4	-0.6	-0.2
Medication: Blood pressure	0.4	0.7	1.9	0.2	0.3	-0.9	-1.4
Medication: Ibuprofen	0.4	0.4	1.1	-1.0	0.5	-0.6	0.3
Medication: Omeprazole	0.4	0.5	1.1	0.0	-0.0	0.8	1.1
Leg pain on walking	0.4	0.5	1.4	-0.4	-0.6	-0.2	1.2
Medication: Aspirin	0.4	0.5	0.9	-0.7	1.0	-0.7	0.6
Smoking status: Previous	0.4	0.6	1.6	-1.3	-0.1	-0.6	-0.7
Arm fat percentage (left)	0.4	1.5	2.8	-1.7	-0.6	0.3	-1.7
Mood swings	0.4	0.6	1.7	0.5	-1.3	0.6	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.3	0.4	-0.9	0.0	1.1
Medication: Aspirin	0.4	0.5	0.8	-0.9	0.9	-0.8	-0.1
Medication: Gliclazide	0.4	0.5	1.6	0.2	-1.3	0.3	0.3
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-1.0	-0.0	0.5	0.8
Bipolar Disorder (2018)	0.3	0.5	1.5	-0.5	-0.5	0.3	1.2
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.1	-0.1	0.9	-0.3	-1.7
Alzheimer’s Disease (in mother)	0.3	0.4	1.1	-1.0	-0.4	-0.3	0.5
Coronary Artery Disease (CAD)	0.3	0.4	1.2	-0.2	0.3	-1.1	-0.3
Lupus	0.3	0.5	1.9	-0.3	-1.4	0.2	-0.2
Primary Biliary Cirrhosis	0.3	0.4	1.3	0.3	0.3	0.3	1.2
Heel T-Score	0.3	2.2	4.4	-2.1	-1.1	-1.2	-1.3
Systolic Blood Pressure	0.3	1.5	5.2	2.3	0.8	-0.6	0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.7	0.5	-0.4	-1.3	-0.6
Lung FVC	0.3	1.3	2.2	1.2	1.5	0.3	1.2
Hearing difficulty/problems: Yes	0.3	0.5	1.0	-0.2	-0.7	-0.6	-1.0
Supplements: Zinc	0.3	0.4	1.1	0.0	0.3	0.4	1.1
Diabetes (mother)	0.3	0.3	0.7	0.8	-0.8	-0.3	-0.0
Pack years adult smoking proportion	0.3	0.5	1.5	0.0	0.4	1.2	0.4
Impedance of leg (right)	0.3	1.4	3.4	-1.9	-0.3	0.9	1.2
Hand grip strength (right)	0.3	0.7	1.1	-0.8	1.1	-1.0	-0.4
Taking other prescription medications	0.3	0.5	1.1	0.4	-1.0	0.4	-0.8
Stomach or abdominal pain in last month	0.3	0.3	0.7	-0.1	-0.3	-0.7	0.9
Nervous feelings	0.3	0.6	2.1	0.5	-0.2	-0.4	1.4
Forced vital capacity (FVC)	0.3	1.1	1.6	1.2	1.1	0.1	1.3
Number of live births	0.3	0.4	0.9	-0.4	-0.2	0.9	0.7
Noisy workplace	0.3	0.4	1.2	0.4	0.2	1.1	-0.2
Depression (self-reported)	0.3	0.4	0.9	0.5	0.5	-0.2	-1.0
Tense / ‘highly strung’	0.3	0.4	1.3	1.1	0.1	-0.3	0.6
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.1	0.2	0.3	0.6	-1.0
Leg fat percentage (right)	0.3	1.1	1.9	-1.4	-0.8	0.5	-1.2
Comparative body size at age 10	0.3	0.9	1.2	0.3	1.1	-1.0	1.1
Age at first live birth	0.3	0.5	0.7	0.7	0.7	-0.8	-0.5
Shortness of breath walking on level ground	0.3	0.4	1.0	0.5	-0.4	-0.2	-1.0
Angina (self-reported)	0.3	0.3	0.6	-0.8	-0.7	0.4	0.3
Illnesses of father: Heart disease	0.3	0.4	1.1	-0.4	-1.0	-0.5	0.3
Loneliness, isolation	0.3	0.4	0.9	1.0	-0.6	0.3	-0.2
Diabetes diagnosed by doctor	0.3	0.4	1.0	1.0	-0.7	-0.2	-0.5
Commuting to job workplace: Walk	0.3	0.3	0.6	0.6	0.8	0.2	-0.3
Ever smoked	0.3	0.6	1.6	-1.3	-0.3	0.0	0.7
Leg fat percentage (left)	0.3	1.1	2.1	-1.2	-0.8	0.1	-1.4
Unable to work because of sickness or disability	0.3	0.3	0.7	-0.0	-0.6	0.8	0.5
Myopia	0.3	0.4	1.4	-0.4	-1.2	0.3	0.2
Pack years of smoking	0.3	0.5	1.8	-0.4	-0.0	1.4	-0.1
Impedance of whole body	0.3	1.4	4.4	-2.1	-0.4	0.6	0.6
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	-0.2	-0.8	-0.6	-0.9
Depression (Nagel 2018)	0.2	0.3	0.8	0.7	0.1	-0.3	0.9
Neuroticism (Nagel 2018)	0.2	0.4	0.9	0.4	-1.0	-0.6	-0.1
Worry (Nagel 2018)	0.2	0.3	0.7	0.8	0.0	-0.7	0.4
Irritable Bowel Disease (IBD)	0.2	0.6	0.8	0.7	-0.9	0.4	0.9
Height	0.2	4.0	11.9	-0.2	-1.5	1.2	3.5
Waist Hip Ratio (WHR)	0.2	0.8	2.2	0.8	1.5	0.3	0.0
Systolic blood pressure, automated reading	0.2	0.7	1.3	1.1	0.1	-0.2	-1.1
Diabetes (father)	0.2	0.3	0.4	0.7	0.4	0.3	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.9	0.9	-0.3	-0.1	0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.1	0.5	0.4	-0.5
Sitting height	0.2	1.2	4.0	2.0	0.6	0.1	0.7
Impedance of leg (left)	0.2	1.1	3.1	-1.8	-0.1	0.3	1.0
Trunk fat mass	0.2	1.0	1.8	-1.4	-0.7	0.5	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.8	0.9	0.6	-0.9	0.5
Hip circumference	0.2	0.8	1.4	0.1	-0.7	1.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.7	0.5	-0.3	0.1
Standing height	0.2	1.9	4.9	1.1	0.1	1.2	2.2
Arm fat-free mass (right)	0.2	1.1	2.2	1.5	1.1	0.4	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.6	0.2	-0.3	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.8	-0.2	-0.5	-0.5
Whole body fat mass	0.2	0.7	1.3	-1.2	-0.5	0.4	-1.0
Arm predicted mass (right)	0.2	1.0	2.8	1.7	0.8	0.5	0.6
Age at last live birth	0.2	0.3	0.7	0.0	0.2	-0.5	-0.9
Family relationship satisfaction	0.2	0.3	0.7	-0.8	-0.4	0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.8	-0.4	0.9	-0.3	0.9
Whole body fat-free mass	0.2	1.2	3.2	1.8	0.8	0.5	0.9
Average weekly red wine intake	0.2	0.2	0.6	-0.3	0.8	-0.4	0.3
Friendships satisfaction	0.2	0.2	0.7	0.2	-0.2	0.2	-0.8
Whole body water mass	0.2	1.0	2.7	1.6	0.8	0.3	0.8
Arm fat mass (left)	0.2	0.7	1.4	-1.0	-0.5	0.3	-1.2
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.2	-0.7	-0.1	0.4
Irritability	0.2	0.3	0.6	0.6	-0.4	0.8	0.3
Arm predicted mass (left)	0.2	0.8	2.8	1.7	0.5	0.3	0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.7	-0.3	-0.4	0.8
Schizophrenia (2018)	0.1	0.2	0.6	-0.5	0.0	-0.8	-0.0
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.0	0.6	-0.4	0.7
Breast Cancer	0.1	0.2	0.6	0.2	0.4	-0.8	-0.4
Neuroticism (2016)	0.1	0.2	0.3	0.4	0.3	-0.4	0.5
Schizophrenia (2014)	0.1	0.2	0.3	-0.0	-0.3	-0.4	-0.6
Ulcerative Colitis	0.1	0.2	0.3	0.2	0.1	0.6	0.5
Blood Eosinophil Count	0.1	0.9	2.7	-0.6	-0.4	-1.6	-0.6
Blood White Count	0.1	0.6	1.9	-0.2	1.4	-0.7	-0.2
Smoking Status	0.1	0.3	0.7	-0.8	-0.3	0.1	0.6
Hair Pigment	0.1	3.1	6.9	-2.6	-1.8	0.5	-1.5
Tanning	0.1	0.7	2.5	0.4	0.2	0.2	1.6
Hand grip strength (left)	0.1	0.3	0.6	0.1	0.4	-0.8	-0.5
Number of treatments/medications taken	0.1	0.2	0.4	-0.4	-0.4	-0.0	-0.6
Leg fat-free mass (left)	0.1	0.4	1.0	1.0	0.2	0.5	0.3
Fed-up feelings	0.1	0.1	0.2	0.4	-0.2	0.5	-0.1
Medication: Levothyroxine sodium	0.1	0.2	0.4	-0.3	-0.5	0.7	0.2
Body mass index (BMI)	0.1	0.4	1.7	-0.2	0.1	0.1	-1.3
Leg predicted mass (left)	0.1	0.3	1.0	1.0	0.2	0.5	0.2
Waist circumference	0.1	0.2	0.7	0.2	-0.0	0.5	-0.8
Number of incorrect matches in round	0.1	0.2	0.6	-0.5	-0.2	-0.8	-0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.4	0.2	0.1	-0.4
Arm fat mass (right)	0.1	0.6	1.1	-1.0	-0.6	0.3	-1.0
Exposure to tobacco smoke at home	0.1	0.2	0.3	-0.1	0.3	-0.5	0.5
Health satisfaction	0.1	0.2	0.5	-0.1	0.1	-0.4	0.7
Qualifications: College or University degree	0.1	0.4	1.0	0.5	-0.1	-1.0	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.4	-0.1	0.4	0.0
Leg fat mass (right)	0.1	0.4	0.6	-0.7	-0.7	0.5	-0.8
Comparative height size at age 10	0.1	0.6	0.8	0.6	-0.9	-0.6	-0.8
Number of full sisters	0.1	0.1	0.2	-0.2	0.1	-0.1	0.5
Leg fat-free mass (right)	0.1	0.4	1.2	1.1	0.5	0.0	0.1
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.2	0.0	-0.6	-0.5
Leg predicted mass (right)	0.1	0.4	1.4	1.2	0.4	-0.0	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.5	-0.2	-0.7	0.3	-0.1
Basal metabolic rate	0.1	0.7	1.9	1.4	0.6	0.4	0.6
Arm fat-free mass (left)	0.1	0.6	2.1	1.4	0.5	0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.3	0.0	0.4	0.4
Leg fat mass (left)	0.1	0.4	0.5	-0.6	-0.7	0.4	-0.7
Rheumatoid Arthritis	0.0	0.1	0.1	-0.4	0.0	-0.1	0.2
BMI	0.0	0.2	0.3	0.5	0.6	0.5	0.4
Neuroticism	0.0	0.1	0.3	-0.1	-0.3	-0.5	-0.0
Weight	0.0	0.2	0.5	0.4	0.1	0.7	-0.3
Worrier / anxious feelings	0.0	0.0	0.1	0.0	-0.2	-0.2	-0.3
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	0.2	0.2	0.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.0	0.2	0.0	0.2
Number of self-reported non-cancer illnesses	0.0	0.1	0.3	0.0	0.1	-0.1	-0.6

Hub : Genes

HK1

Models

Trait associations