TWAS hub - CYP2C8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0630	0.0270	7.5e-04	0.036	0.022	0.027	0.025	0.037	3.1e-05	9.5e-04	2.8e-04	4.4e-04	2.1e-05
2	GTEx	Artery Aorta	0.2070	0.0730	1.5e-03	-0.002	NA	-0.004	NA	0.003	4.6e-01	NA	5.8e-01	NA	2.2e-01
3	GTEx	Muscle Skeletal	0.1165	0.0453	2.9e-03	0.062	NA	0.045	NA	0.062	1.1e-06	NA	2.8e-05	NA	1.1e-06
4	GTEx	Pituitary	0.1980	0.0770	3.1e-03	0.045	NA	-0.011	NA	0.038	2.7e-02	NA	7.8e-01	NA	4.1e-02
5	GTEx	Small Intestine Terminal Ileum	0.3970	0.0910	3.9e-06	0.359	NA	0.359	NA	0.401	6.3e-09	NA	6.7e-09	NA	5.1e-10
6	GTEx	Testis	0.2200	0.0760	1.1e-03	0.094	NA	0.075	NA	0.080	5.9e-05	NA	3.1e-04	NA	2.0e-04
7	GTEx	Thyroid	0.1100	0.0370	1.8e-04	0.027	NA	0.051	NA	0.058	3.6e-03	NA	8.7e-05	NA	2.8e-05
8	ROSMAP	Brain Pre-frontal Cortex	0.0874	0.0285	7.5e-07	0.023	0.058	0.051	0.060	0.038	5.3e-04	5.8e-08	3.3e-07	3.4e-08	9.6e-06
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.1916	0.0632	5.2e-05	-0.002	0.030	0.058	NA	0.014	7.6e-01	2.3e-04	4.0e-07	NA	1.0e-02
10	TCGA	Brain Lower Grade Glioma	0.0377	0.0236	8.0e-03	-0.002	0.005	0.002	NA	-0.002	9.9e-01	7.5e-02	1.6e-01	NA	8.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Had major operations	4.0	4.7	10.7	2.0	1.5	1.6	2.4	1.8	1.9	1.6	3.3	2.4	2.6
Chest pain or discomfort	3.8	5.5	8.1	1.9	0.5	2.3	2.2	2.6	2.8	1.8	2.8	2.6	2.8
High blood pressure (siblings)	3.6	5.2	16.7	-1.8	-0.8	-2.3	0.1	-0.1	-3.2	-4.1	-3.4	-0.4	-1.9
Heart attack/myocardial infarction (self-reported)	3.6	4.6	10.1	2.4	0.5	1.9	1.7	3.1	2.4	0.0	1.9	3.2	2.1
Heart attack	3.5	4.5	10.7	2.4	0.7	2.0	1.7	2.9	2.4	-0.0	1.9	3.3	1.9
Number of operations (self-reported)	3.5	5.1	11.9	1.5	1.5	1.9	2.3	2.2	1.8	1.4	3.4	3.2	2.4
Diastolic blood pressure, automated reading	3.5	10.9	23.0	-1.2	-4.8	-4.5	-2.1	-2.2	-3.9	-1.6	-3.4	-4.8	-1.6
Medication: Aspirin	3.4	4.5	7.2	2.3	0.5	2.1	2.1	2.0	2.4	1.6	2.7	2.0	2.6
Mouth/teeth dental problems: Dentures	3.3	5.6	15.7	2.6	-1.8	1.0	4.0	3.6	1.3	-0.3	2.3	1.2	2.9
Systolic Blood Pressure	2.9	14.5	40.3	-2.1	-6.3	-4.7	-2.5	-1.8	-3.7	-1.4	-5.8	-4.4	-0.9
Systolic blood pressure, automated reading	2.9	8.5	27.2	-0.5	-5.2	-3.8	-0.7	-0.4	-3.2	-2.2	-3.9	-3.4	-0.3
Illnesses of siblings	2.9	4.1	19.8	1.0	0.0	1.8	-1.2	-1.2	2.7	4.5	2.2	-0.3	1.4
Wheeze or whistling in the chest in last year	2.9	5.2	11.9	3.4	1.3	2.5	2.1	2.4	2.5	1.2	2.2	2.4	2.2
Medication: Ventolin 100micrograms inhaler	2.8	3.6	9.2	3.0	0.4	1.2	0.9	2.1	1.7	2.2	1.2	2.6	1.9
Birth weight of first child	2.7	5.0	15.0	-1.9	1.0	-1.6	-3.9	-3.6	-1.9	2.2	0.4	-0.8	-2.3
Medication: Aspirin	2.7	3.6	6.2	2.1	0.6	1.8	1.9	1.9	2.0	1.3	2.3	2.1	2.5
Medication: Cholesterol lowering	2.6	4.1	18.1	4.3	1.3	2.1	0.2	1.5	2.6	1.5	1.2	1.3	1.5
Hearing difficulty/problems: Yes	2.4	3.6	9.8	2.2	-0.7	1.0	2.1	2.6	1.4	0.5	1.6	2.1	3.1
Angina (self-reported)	2.4	3.1	9.3	2.0	0.3	1.0	1.1	1.3	1.4	1.8	1.9	3.0	2.2
Angina	2.3	3.0	8.1	1.8	0.5	1.0	1.3	1.2	1.3	1.9	2.1	2.9	2.2
Pulse wave peak to peak time	2.3	2.7	6.9	-2.6	2.2	0.2	-2.0	-2.3	-0.3	0.4	-1.2	1.5	-1.2
Wears glasses or contact lenses	2.3	2.6	5.6	1.7	0.6	1.3	1.5	1.3	1.8	1.7	2.1	1.2	2.4
Myopia	2.3	3.3	8.6	2.9	-0.8	1.2	1.1	1.7	2.2	1.6	2.4	1.6	1.8
Impedance of whole body	2.3	11.5	37.9	1.1	-2.3	-2.1	-6.2	-3.9	-1.1	1.9	-4.7	-4.2	-2.4
Impedance of arm (right)	2.2	10.4	33.4	0.1	-1.3	-1.4	-5.8	-3.9	-1.0	0.7	-4.4	-4.7	-2.9
Number of children fathered	2.2	2.4	7.2	-1.2	-1.3	-2.4	-0.0	-0.2	-2.7	-1.9	-1.4	-0.9	-1.3
Impedance of leg (right)	2.1	10.0	34.3	1.8	-2.1	-1.6	-5.9	-3.6	-0.4	3.2	-4.1	-3.6	-1.5
High blood pressure (mother)	2.1	3.0	6.2	-1.5	-2.5	-2.2	-0.6	-0.8	-2.1	-1.7	-2.1	-1.2	-1.6
Pulse wave Arterial Stiffness index	2.1	2.4	5.7	2.4	-2.4	-0.6	1.7	2.0	-0.0	-0.5	1.1	-1.7	0.9
Bipolar Disorder (2011)	1.9	1.8	6.4	2.5	0.7	2.1	-0.2	1.7	2.0	-0.1	0.4	0.0	0.3
Coronary Artery Disease (CAD)	1.9	2.2	4.9	1.1	1.1	2.2	1.6	1.0	2.2	1.1	1.9	0.0	1.2
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	4.7	2.2	0.5	2.0	0.8	0.9	2.0	1.3	2.0	0.2	1.5
Impedance of leg (left)	1.9	9.4	29.2	1.9	-2.6	-2.1	-5.4	-3.3	-0.9	2.7	-4.3	-3.2	-1.3
Respiratory disease	1.8	4.0	7.3	1.4	1.1	1.8	2.2	1.7	2.0	1.7	2.7	2.6	2.3
High blood pressure	1.8	5.0	14.7	1.0	-3.8	-2.6	-2.0	-0.4	-1.5	-0.7	-3.2	-3.0	-1.0
Chronic bronchitis/emphysema (father)	1.8	2.1	6.4	1.4	-0.5	-0.1	2.5	1.9	-0.0	-0.1	1.8	1.6	1.7
Impedance of arm (left)	1.8	8.4	28.8	0.3	-1.1	-0.9	-5.4	-3.5	-0.6	0.9	-4.1	-4.0	-2.6
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	12.0	-0.3	0.6	-0.6	-3.5	-2.2	-1.0	0.3	-1.7	-1.0	-2.3
Chronic bronchitis/emphysema (mother)	1.8	2.1	6.5	1.2	1.5	1.0	0.6	-0.4	1.2	2.5	2.3	0.9	1.4
Family relationship satisfaction	1.8	2.2	5.5	-1.7	-1.5	-2.3	-0.1	-0.1	-2.3	-1.8	-1.1	-0.7	-1.0
Illnesses of siblings: Diabetes	1.8	2.2	6.6	-0.0	-1.7	-1.7	2.6	1.8	-1.4	-2.1	-0.2	0.3	0.0
Maternal smoking around birth	1.7	2.4	7.2	1.4	0.2	1.3	1.1	0.9	1.7	2.3	1.5	1.1	2.7
Qualifications: None of the above	1.7	3.7	14.6	1.8	0.8	1.5	3.8	2.1	1.0	-0.6	1.6	1.1	2.6
Medication: Simvastatin	1.7	2.5	8.2	2.0	-0.4	0.9	-0.2	0.3	2.2	2.9	1.2	1.0	2.1
Headache pain in last month	1.7	2.8	6.6	-1.8	-1.4	-1.1	-2.2	-2.4	-0.6	0.5	-1.8	-2.6	-1.0
Smoking status: Previous	1.7	2.6	7.0	1.9	0.0	1.9	0.8	1.2	2.2	1.6	1.5	-0.1	2.6
Medication: Blood pressure	1.7	3.3	7.8	-1.9	-2.8	-2.1	-1.7	-1.3	-1.5	-0.2	-2.4	-2.1	-0.7
Medication for hormone replacement therapy	1.6	1.8	3.5	1.3	1.2	1.3	1.0	0.1	1.3	1.8	1.9	0.8	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	5.3	1.2	0.5	0.3	0.6	0.7	0.5	1.9	1.9	2.3	1.5
Blood clot in the leg (DVT)	1.6	2.0	7.9	0.7	2.8	2.6	0.0	0.8	1.8	0.0	-0.2	1.1	0.1
Comparative body size at age 10	1.6	4.4	10.0	1.1	2.8	2.8	3.2	2.1	2.2	0.3	2.1	1.1	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	5.5	0.8	-0.7	1.2	1.9	1.4	1.4	1.2	1.6	0.6	2.3
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.6	-1.8	-0.9	-1.2	-0.4	-1.1	-1.4	-1.9	-1.1	-1.8	-1.6
Migraine (self-reported)	1.6	2.0	6.6	0.6	-2.0	-0.4	-2.6	-0.7	1.0	2.5	-0.4	-0.2	0.9
Hypertension (Self-reported)	1.6	4.5	12.8	1.1	-3.6	-2.4	-2.0	-0.1	-1.2	-0.7	-3.2	-2.8	-0.9
Ever had bowel cancer screening	1.6	1.8	5.4	1.4	-1.2	1.0	0.2	2.3	1.7	0.7	0.3	1.0	1.9
Ever taken oral contraceptive pill	1.6	1.8	4.7	-1.1	0.7	-0.9	-2.1	-1.7	-1.0	0.2	-1.0	-1.1	-2.2
Heart disease (siblings)	1.6	1.9	3.9	1.9	2.0	1.7	1.0	1.5	0.9	-0.6	0.9	1.7	1.0
Blood White Count	1.5	10.8	55.2	3.6	-7.4	-2.2	-1.1	2.0	1.3	3.6	-0.6	-0.6	3.8
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	4.5	0.2	1.7	1.5	2.0	0.3	1.0	0.4	2.1	1.5	0.5
Number of incorrect matches in round	1.5	2.5	5.5	2.4	0.9	1.6	1.5	0.9	1.9	1.2	1.6	0.8	2.1
Noisy workplace	1.5	1.9	4.2	1.1	1.9	1.0	1.2	0.0	0.9	1.7	1.9	0.6	2.0
Depression (self-reported)	1.5	1.7	5.5	1.3	-0.5	1.2	1.2	2.3	1.7	-0.1	1.0	0.5	1.7
Asthma (self-reported)	1.5	3.0	6.4	1.5	0.4	1.6	1.6	1.8	2.0	1.3	2.0	2.5	1.9
High cholesterol (Self-reported)	1.5	2.6	7.5	2.7	0.3	1.6	-0.2	1.5	2.5	1.9	0.6	1.4	1.3
Worry too long after embarrassment	1.4	2.3	10.9	-1.1	-3.3	-1.6	-1.6	-0.5	-0.5	0.6	-1.7	-1.4	0.3
Back pain experienced in last month	1.4	2.0	8.2	1.2	-0.6	-1.0	2.9	1.4	-1.3	-2.1	0.2	0.6	0.4
Medication: Bendroflumethiazide	1.4	2.1	3.5	-1.9	-1.8	-1.6	-0.4	-0.6	-1.3	-1.4	-1.4	-1.9	-1.3
Alcohol drinker status: Previous	1.4	1.6	4.8	-2.2	-0.5	-1.4	-0.7	-1.4	-1.3	-0.9	-1.3	-0.5	-1.5
Cardiovascular Disease	1.3	4.2	12.9	1.0	-2.9	-1.4	-3.1	-0.7	-0.2	0.1	-3.6	-2.3	-1.6
Past tobacco smoking	1.3	2.5	6.0	-2.0	-1.4	-2.5	-0.1	-0.4	-2.4	-1.7	-0.8	-0.0	-1.8
Illnesses of father: High blood pressure	1.3	1.7	3.3	-1.0	-0.1	-1.2	-1.6	-1.4	-1.4	-0.5	-1.8	-1.3	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	6.6	0.6	2.6	2.2	0.2	0.7	1.5	-0.4	-0.6	1.2	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	5.4	1.5	-0.6	0.4	0.6	0.7	1.2	2.3	1.2	1.0	1.8
Stomach or abdominal pain in last month	1.2	1.5	5.7	-0.0	-2.4	-2.0	1.3	-0.1	-1.5	-0.4	0.2	-0.6	1.0
Father’s age at death	1.2	1.6	4.1	0.7	1.1	0.9	2.0	1.7	0.7	-0.1	0.9	2.0	1.3
Pulse rate	1.2	2.1	4.9	-1.7	0.0	-1.2	1.5	-0.5	-2.1	-2.2	0.3	-1.9	-1.0
Asthma	1.2	2.4	5.2	1.4	0.4	1.6	1.4	1.7	2.0	1.0	1.4	2.3	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	8.4	-1.8	-0.3	-2.4	-2.3	-2.6	-2.9	0.2	-0.9	-2.6	-1.3
Pulse wave reflection index	1.2	1.5	6.3	0.6	-2.5	-0.9	1.0	1.3	-0.4	-0.8	-0.7	-1.7	0.4
Birth weight	1.2	2.7	7.7	-2.4	2.0	-0.0	-1.5	-2.8	-1.1	-0.4	-0.6	-1.3	-1.9
Exposure to tobacco smoke outside home	1.2	1.6	4.0	2.0	-0.8	0.9	1.1	1.1	1.4	0.4	0.9	-1.6	1.5
Number of full sisters	1.2	1.4	6.3	0.0	1.6	2.5	0.7	0.4	1.8	-0.5	-0.7	0.8	-0.3
Suffer from ‘nerves’	1.2	1.8	4.0	1.5	-0.8	1.6	1.3	2.0	1.9	0.6	1.1	0.6	1.4
Cholesterol lowering medication	1.2	1.8	7.5	-0.7	-0.2	0.5	-0.5	-0.0	1.4	2.7	0.8	1.9	1.7
Schizophrenia vs Biploar Disorder	1.1	1.4	3.6	-0.0	0.0	0.5	1.6	0.8	0.6	1.7	1.9	-0.3	1.9
Neuroticism	1.1	2.5	7.1	1.5	-2.2	0.3	1.8	1.6	0.8	1.2	2.0	0.1	2.7
Townsend deprivation index at recruitment	1.1	1.6	4.0	1.7	-0.2	0.6	0.1	1.4	1.5	1.6	0.6	2.0	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	5.8	-1.0	1.0	0.7	-2.4	-1.6	0.6	0.5	-0.5	-0.9	-1.2
Prospective memory result	1.1	1.3	5.6	1.0	2.4	2.0	-0.1	0.1	1.4	-0.0	0.4	0.2	-0.5
Length of working week for main job	1.1	1.2	4.9	-1.0	2.2	1.4	-0.5	-0.8	0.8	-0.7	-0.5	0.2	-1.4
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	13.5	-3.7	0.7	-0.2	0.2	-1.0	-1.1	-0.6	-0.3	-0.2	-1.2
Forced vital capacity (FVC), Best measure	1.1	4.0	9.3	-2.5	-1.0	-2.6	-1.6	-2.5	-3.0	0.1	-1.1	-2.2	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.4	-1.4	-1.0	-1.7	-0.1	-0.7	-1.9	-0.7	-0.7	-1.1	-1.2
Medication: Atorvastatin	1.1	1.4	4.0	2.0	0.5	1.8	-0.8	1.2	1.7	0.7	0.0	1.0	-0.4
Vascular/heart problems diagnosed by doctor	1.1	3.1	10.1	-1.8	3.2	1.6	1.6	-0.3	0.5	0.3	2.6	2.1	0.2
Hand grip strength (left)	1.0	2.7	6.0	-2.4	0.3	-1.1	-0.8	-2.5	-1.7	-0.5	-1.2	-2.3	-1.9
Number of treatments/medications taken	1.0	1.7	4.0	1.9	0.7	1.1	1.0	1.2	1.4	0.4	1.1	2.0	1.4
Hand grip strength (right)	1.0	2.7	5.4	-2.3	0.2	-1.0	-1.0	-2.1	-1.7	-0.8	-1.6	-2.1	-2.3
Nervous feelings	1.0	1.9	7.8	0.6	-0.2	1.1	-0.3	-0.2	1.5	2.8	1.5	-1.6	1.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	4.5	1.7	-1.2	-0.0	0.5	1.4	0.4	0.7	0.7	-0.2	2.1
Mouth/teeth dental problems	1.0	1.5	5.2	-0.7	0.4	-1.0	-2.0	-2.3	-0.7	1.3	-0.8	-0.8	-0.8
Time employed in main current job	1.0	1.1	4.6	-2.0	0.9	-0.2	-0.4	-2.1	-0.6	0.7	-0.6	-0.5	-0.5
Lung cancer (father)	1.0	1.2	3.7	1.0	-1.0	-1.0	1.7	0.5	-0.7	0.7	1.2	-0.2	1.9
Medication: Ibuprofen	1.0	1.1	3.3	0.0	1.8	1.7	-1.2	-0.7	1.5	0.8	0.6	-0.2	-0.4
Medication: Seretide 50 evohaler	1.0	1.2	3.3	0.4	1.0	0.9	1.0	0.4	1.4	1.0	1.8	0.8	1.4
Friendships satisfaction	1.0	1.2	3.8	-0.7	-2.0	-1.7	0.1	-0.1	-1.7	-1.1	-0.3	-1.0	-0.1
Osteoarthritis (self-reported)	1.0	1.3	3.4	1.8	-1.0	-0.4	1.2	0.8	0.2	1.2	1.8	-0.1	1.4
Mother’s age at death	1.0	1.3	3.1	1.3	1.0	1.0	1.8	1.4	0.6	0.1	1.5	0.0	1.2
Ever smoked	1.0	1.8	4.2	1.5	1.7	2.0	-0.6	-0.0	2.0	1.7	0.6	-0.2	1.0
Ever depressed for a whole week	1.0	1.3	3.8	2.0	-1.3	-0.2	1.0	1.4	0.2	0.4	0.6	-0.4	1.8
Depression (Nagel 2018)	0.9	1.4	2.8	1.6	-0.5	0.1	1.5	1.0	0.5	1.5	1.7	0.2	1.6
Lupus	0.9	1.4	4.4	-0.1	1.7	0.9	-0.8	-0.9	1.1	1.7	0.7	2.1	0.4
Supplements: Zinc	0.9	1.0	4.5	0.3	-0.7	0.1	2.1	1.1	0.5	-0.2	1.5	-0.5	0.9
Medication: Atenolol	0.9	1.1	5.5	0.6	-2.3	-1.4	-0.1	0.8	-0.2	0.8	-1.1	-0.1	0.9
Had menopause	0.9	1.1	3.8	0.4	-0.0	1.2	0.7	0.6	1.4	1.4	0.8	0.8	1.9
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	8.6	-1.3	-1.5	-2.5	-1.7	-1.5	-2.9	-0.5	-0.8	-2.0	-1.5
Medication: Omeprazole	0.9	1.0	2.2	1.5	-1.4	-0.7	1.0	0.8	-0.3	0.4	1.5	-0.7	1.1
Mean time to correctly identify matches	0.9	1.8	4.5	2.1	0.0	1.2	1.2	1.9	1.6	-0.1	-0.3	-1.0	1.9
Leg pain on walking	0.9	1.1	5.2	2.3	-0.5	0.9	0.3	1.5	1.1	0.0	-0.0	-0.0	0.9
Medication for cholesterol	0.9	1.3	3.7	1.9	1.0	1.3	1.0	1.7	0.8	-1.2	0.9	0.1	0.2
Mineral and other dietary supplements	0.9	1.3	4.6	1.1	1.1	1.5	-0.5	0.5	2.1	1.1	1.2	-0.3	0.4
Guilty feelings	0.9	1.3	6.0	0.4	-1.1	0.2	-0.2	-0.2	0.7	2.4	0.8	-0.4	2.1
Primary Biliary Cirrhosis	0.8	1.1	3.1	-1.7	0.1	-0.8	-1.1	-1.8	-1.0	0.2	-1.2	-0.5	-0.5
Blood Eosinophil Count	0.8	5.8	15.8	3.5	0.1	1.9	-0.3	1.0	3.5	4.0	1.4	2.3	2.5
Blood Red Count	0.8	7.3	42.5	-2.0	-6.5	-3.2	0.6	-0.9	-2.4	1.0	-1.5	-1.4	2.1
Forced vital capacity (FVC)	0.8	2.9	8.4	-2.0	-2.0	-2.7	-0.8	-1.1	-2.9	-0.6	-0.4	-1.7	-0.8
Financial difficulties in last 2 years	0.8	1.1	2.7	1.6	0.4	1.1	0.6	0.5	1.3	1.2	0.9	-1.3	1.0
Medication: Ramipril	0.8	1.1	3.4	1.0	1.0	0.3	-1.8	-1.3	0.5	1.5	-0.7	0.5	-0.5
Number of live births	0.8	1.1	3.9	1.1	-2.0	-0.6	0.0	1.8	0.1	-0.2	-0.6	0.8	1.2
Hair/balding pattern: Pattern 4	0.8	2.0	3.6	1.8	1.6	1.9	1.7	1.4	1.4	-0.6	1.4	1.1	0.7
Glaucoma (self-reported)	0.8	0.9	2.6	-0.0	-1.4	-0.6	1.0	1.2	-0.2	0.1	0.6	1.6	1.1
Eye problems/disorders: None of the above	0.8	1.0	2.5	-0.6	1.6	0.9	-0.7	-1.5	0.7	0.5	0.6	-1.2	-1.0
Emphysema/chronic bronchitis	0.8	0.9	2.8	0.2	-0.2	0.6	1.7	0.8	0.7	0.4	1.6	0.7	1.2
Heart disease (mother)	0.8	0.9	3.4	0.9	-1.1	-0.8	1.8	0.8	-1.1	-0.8	0.1	-0.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.7	-1.2	-0.7	-1.1	-1.4	-1.2	-1.4	-0.7	-1.5	-2.2	-0.9
Eye problems/disorders: Cataract	0.8	0.9	4.9	0.9	-2.2	-0.9	0.1	0.7	-0.4	0.2	-0.8	0.1	1.1
Hearing aid user	0.8	0.9	4.4	-0.1	1.1	-0.1	0.5	0.5	-1.2	-2.1	-1.0	0.4	-0.9
Major Depression (MDD)	0.7	0.9	3.3	-0.2	0.5	0.9	1.0	1.4	0.9	-0.5	0.4	1.8	0.1
Lung FEV1/FVC ratio	0.7	3.6	7.7	-0.7	1.9	-1.5	-2.4	-1.6	-2.6	-1.8	-1.7	-0.8	-2.8
Severe depression (siblings)	0.7	0.8	2.3	0.7	0.3	0.8	-1.5	-0.5	1.0	0.3	-1.3	1.0	-0.8
Current tobacco smoking	0.7	1.2	2.4	-1.5	1.0	-0.5	-1.2	-1.1	-0.7	-0.4	-1.4	0.8	-1.6
Taking other prescription medications	0.7	1.1	3.1	1.8	0.8	0.9	1.1	1.4	1.1	-0.0	0.8	0.6	1.2
Qualifications: CSEs or equivalent	0.7	0.9	2.7	0.2	1.5	0.9	-0.4	-1.0	1.0	1.6	0.8	-0.3	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.0	-0.5	-1.2	-0.3	1.7	0.7	-0.1	0.2	0.8	1.7	1.4
Happiness	0.7	0.9	3.3	-0.7	-1.6	-1.0	0.4	-0.2	-0.9	-0.7	-0.0	-1.8	0.1
Illnesses of mother	0.7	0.9	3.9	-0.5	2.0	1.4	-0.4	-0.5	1.0	0.8	0.4	0.5	-0.1
Leg fat percentage (right)	0.7	2.5	8.1	2.1	-2.8	-1.0	-0.2	0.5	0.6	1.3	-1.1	-2.1	1.9
Shortness of breath walking on level ground	0.7	0.8	3.3	0.1	1.2	0.8	0.0	0.3	0.1	-1.8	-1.2	-0.5	-0.9
Medication: Blood pressure	0.7	1.2	6.1	2.5	-1.5	-1.1	-1.2	0.0	-0.0	0.8	-0.2	-0.5	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.7	1.6	-0.3	0.5	-0.6	0.7	0.7	0.7	-0.4	1.6	0.6
Age at last live birth	0.7	1.0	2.9	0.8	0.3	0.6	0.9	0.1	0.9	1.7	1.4	0.3	1.6
Diabetes diagnosed by doctor	0.7	1.1	3.1	0.6	-1.8	-0.5	-0.4	0.6	0.7	1.5	0.3	1.6	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.0	1.0	-0.3	0.1	1.0	0.2	0.3	1.1	1.4	0.7	1.2
Smoking status: Current	0.7	1.1	2.9	-1.1	1.1	-0.4	-1.2	-1.0	-0.7	-0.4	-1.4	0.7	-1.7
Leg fat percentage (left)	0.7	2.4	8.1	2.2	-2.8	-1.1	0.2	0.6	0.4	1.1	-1.1	-1.6	2.1
Breast Cancer	0.6	1.4	5.0	1.2	-1.1	-0.6	1.7	0.6	0.1	0.9	2.2	0.2	1.3
Crohns Disease (2012)	0.6	1.0	2.8	-1.0	-0.2	0.1	-1.7	-1.4	0.1	0.1	-0.9	-1.1	-1.3
Fasting Glucose	0.6	0.7	4.2	2.0	0.9	1.0	-0.1	1.0	0.3	-0.2	-0.2	0.2	0.2
HbA1C	0.6	0.7	2.4	1.5	-0.9	0.1	0.7	1.6	0.4	-0.3	-0.5	-0.2	0.6
LDL Cholesterol	0.6	0.9	3.3	-0.3	1.6	1.8	-0.7	0.6	1.5	0.3	0.1	-0.5	-0.2
Heel T-Score	0.6	4.5	8.4	1.3	2.8	2.7	2.9	2.2	2.0	0.1	2.5	1.7	1.1
Chronotype (morning person)	0.6	1.3	3.4	0.2	-1.3	-0.8	1.8	1.3	-0.9	-1.4	0.1	-1.7	0.1
Trunk fat percentage	0.6	2.3	6.8	1.6	-2.6	-1.2	-0.8	-0.1	0.0	0.6	-1.9	-2.4	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	6.1	1.1	2.5	1.9	0.4	0.1	1.1	0.1	0.6	0.4	0.2
Multivitamins +/- minerals	0.6	0.7	4.3	-0.4	-0.2	-0.5	-0.0	-0.8	-1.1	-0.6	-0.2	-2.1	-0.3
Had other major operations	0.6	0.7	2.9	0.9	0.6	0.6	0.4	1.3	0.5	0.4	0.3	1.7	0.5
Pain all over the body in last month	0.6	0.6	1.6	-0.9	0.9	-0.2	-1.0	-1.0	-0.2	0.3	-1.3	-0.8	-0.4
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.7	-0.8	-0.4	-0.6	-2.1	-1.3	-1.1	-0.6	-0.7	-0.4	-2.2
Standing height	0.6	6.4	13.8	-2.2	-1.1	-3.4	-2.9	-2.5	-3.7	-1.0	-1.5	-2.5	-2.7
Medication: Amlodipine	0.6	0.8	2.4	0.6	-1.4	-0.4	-1.1	-0.9	0.3	0.6	-0.6	-1.6	0.1
Body fat percentage	0.6	2.3	7.1	1.7	-2.7	-1.1	-0.5	0.2	0.3	0.7	-1.7	-2.2	1.6
Age at first live birth	0.6	1.1	4.8	0.5	0.5	0.4	0.4	-0.9	0.8	2.2	1.5	-0.8	1.2
Health satisfaction	0.6	0.8	2.1	0.2	0.2	-0.4	-1.2	-1.3	-0.4	-0.2	-1.4	0.3	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.0	1.4	-1.0	-0.4	0.4	0.9	-0.2	-0.2	-0.4	-0.6	1.4
Qualifications: nursing, teaching	0.6	0.9	3.0	-0.6	0.8	-0.7	-1.3	-1.3	-0.8	0.2	0.1	0.5	-1.7
Osteoporosis (self-reported)	0.6	0.8	3.2	-1.8	-0.7	0.1	-0.5	-0.5	0.9	1.1	-1.0	-0.6	0.6
Eye problems/disorders: Glaucoma	0.6	0.7	3.5	0.5	-0.3	0.3	0.9	1.0	0.2	-0.0	0.0	1.9	1.0
Commuting to job workplace: Cycle	0.6	0.7	1.7	-0.3	1.3	0.4	-0.9	-1.2	-0.0	0.2	-0.7	1.1	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.1	1.4	-0.8	-0.6	0.5	-0.2	-0.3	1.2	1.1	-0.2	0.9
Depressed Affect (Nagel 2018)	0.5	1.0	3.0	0.6	-0.9	-0.1	1.5	0.7	0.4	0.9	1.4	0.3	1.7
Neuroticism (Nagel 2018)	0.5	1.2	3.6	0.3	-1.9	-0.2	0.6	0.5	0.4	1.4	1.3	-0.4	1.8
Ovarian Cancer	0.5	0.7	2.2	1.5	-1.4	-0.0	-0.5	1.1	0.2	-0.2	-0.7	-0.9	0.2
Prostate Cancer	0.5	0.7	1.9	1.4	1.0	1.3	0.5	0.5	0.8	-0.1	0.8	0.7	0.4
Mean Putamen Volume	0.5	0.6	1.7	1.0	1.3	0.3	-0.5	-0.8	-0.0	0.9	1.1	0.5	0.1
Waist Hip Ratio (WHR)	0.5	2.1	8.8	1.8	-1.6	-0.4	1.5	3.0	0.2	0.2	0.4	1.1	1.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.9	-0.2	-1.7	-0.8	-0.6	0.0	-0.4	0.2	-0.8	-1.1	0.5
Ever had hysterectomy (womb removed)	0.5	0.6	2.2	0.9	-0.7	0.8	-0.2	0.6	1.5	0.9	-0.4	-0.0	0.8
Medication: Metformin	0.5	0.8	2.7	0.4	-1.6	-0.6	0.9	1.1	0.3	-0.0	1.0	0.8	1.0
Diabetes (mother)	0.5	0.6	3.0	-0.4	1.7	1.0	0.2	-0.4	0.5	0.5	0.1	1.2	0.3
Fed-up feelings	0.5	0.8	2.4	0.9	0.6	0.7	0.6	0.7	0.8	0.6	1.4	1.5	0.6
Relative age voice broke	0.5	0.8	2.0	-0.7	1.0	-0.5	-0.8	-1.4	-0.9	0.6	0.6	0.5	-1.1
Age when periods started (menarche)	0.5	1.2	5.3	2.3	1.1	0.9	-0.6	1.3	0.5	-0.1	-0.0	1.5	-0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.5	-1.6	0.8	1.2	0.4	-0.2	0.8	0.1	-0.1	-0.1	0.4
Medication: Levothyroxine sodium	0.5	0.8	2.1	1.2	0.3	-0.6	1.5	1.0	-0.7	-1.2	0.6	0.5	0.2
Body mass index (BMI)	0.5	2.1	7.1	0.6	-1.1	0.1	2.7	2.1	0.8	-0.4	1.1	0.3	2.3
Waist circumference	0.5	1.9	5.2	0.9	-2.2	-0.5	1.7	2.3	0.6	-0.4	0.2	-0.5	2.0
Hearing difficulty/problems with background noise	0.5	0.8	3.9	0.9	-0.8	-0.1	0.9	0.3	-0.0	0.1	-1.0	0.6	2.0
Hair/balding pattern: Pattern 2	0.5	0.7	2.4	0.1	-1.5	0.0	0.8	0.5	0.1	0.8	0.9	0.8	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.0	-0.6	-1.7	-0.9	-0.8	-0.8	-0.3	1.3	-0.1	-0.1	0.5
Falls in the last year	0.5	0.7	4.6	-0.8	0.2	-0.0	-0.6	-0.5	0.2	-0.7	-2.1	0.1	-0.7
Hair/balding pattern: Pattern 3	0.5	0.7	2.1	-1.4	0.6	-0.1	-1.0	-0.8	0.2	-0.5	-0.5	-1.3	-0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.3	-1.5	0.9	0.1	-0.7	-0.6	-0.3	-1.0	-0.1	0.2	-1.2
Medication: Allopurinol	0.5	0.7	3.1	1.0	1.8	0.3	-0.4	-0.6	0.4	1.1	0.3	0.8	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	-1.2	-0.1	-0.5	-0.8	-0.9	-0.8	-0.2	-0.5	-1.1	-0.7
Supplements: Vitamin C	0.5	0.6	1.7	-0.5	1.0	0.2	0.9	0.5	-0.7	-1.3	-0.4	0.9	-0.8
Loneliness, isolation	0.5	0.7	2.0	0.1	-0.7	0.3	0.4	0.6	1.1	1.2	1.0	0.6	1.4
Miserableness	0.5	0.8	3.2	0.2	-0.5	0.3	1.2	0.7	0.8	0.8	0.6	0.7	1.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.0	0.5	0.8	0.8	0.4	1.4	0.7	-0.1	-0.1	1.2	0.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.6	-0.8	-0.0	-0.3	-0.8	-1.0	-0.9	0.0	-1.6	0.4	-0.7
Medication: Lisinopril	0.5	0.6	2.0	-0.5	-0.7	-0.8	-1.4	-0.7	-0.5	-0.2	-0.8	-0.7	-0.9
Alcohol drinker status: Never	0.5	0.6	1.9	-0.6	-0.9	-0.5	0.9	0.8	0.1	0.8	-0.8	0.2	1.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.7	0.2	0.5	0.8	1.0	0.9	0.8	-0.3	0.7	-0.6	1.3
Supplements: Calcium	0.5	0.5	1.1	-0.5	-0.9	-0.6	0.7	-0.2	-0.6	0.7	-0.5	-1.0	1.0
Bipolar Disorder (2018)	0.4	0.7	2.0	0.8	-1.4	-0.8	-0.4	-0.4	-0.4	-0.8	-1.4	-0.2	-0.3
Worry (Nagel 2018)	0.4	0.9	3.2	0.2	-1.8	-0.1	0.5	0.7	0.2	0.9	1.0	-0.8	1.4
Alzheimer’s Disease (in mother)	0.4	0.5	2.3	0.8	-1.5	0.1	-0.5	0.7	0.7	0.5	0.5	-0.4	0.4
Alzheimer’s Disease (in father)	0.4	0.4	1.4	0.5	0.9	-0.6	1.2	0.3	-0.9	-0.8	0.1	-0.2	0.1
Age at First Birth	0.4	0.5	2.4	-0.2	0.2	0.3	1.2	-0.4	0.3	0.6	0.8	-0.3	1.6
Triglycerides	0.4	0.7	2.8	1.2	-0.8	-0.0	1.0	1.7	0.2	-0.4	-0.2	-0.3	0.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.9	0.5	-0.1	0.1	1.0	0.3	0.4	1.3	0.9	-0.3	1.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	3.9	-0.4	0.2	-0.4	-0.1	0.1	-0.3	-0.4	-0.6	2.0	-0.4
Vitamin and mineral supplements	0.4	0.5	3.0	0.4	0.3	1.1	-0.5	0.6	1.7	0.3	0.1	0.5	-0.1
Average weekly fortified wine intake	0.4	0.5	1.1	0.5	-1.0	-1.0	0.3	0.6	-1.0	-0.7	-0.7	0.1	0.4
Trunk fat mass	0.4	1.6	5.9	1.0	-2.4	-1.4	-0.1	0.2	-0.4	0.1	-1.2	-1.9	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	5.2	0.6	2.3	1.4	-0.2	-0.6	0.5	0.3	0.2	0.4	-0.4
Diabetes (self-reported)	0.4	0.6	1.7	0.8	-1.3	-0.6	-0.6	0.9	0.2	0.7	-0.2	1.0	0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.2	-0.4	1.0	1.5	0.3	0.2	0.8	-0.7	-0.4	0.7	-0.5
Exposure to tobacco smoke at home	0.4	0.5	1.2	1.0	-1.1	-0.0	-0.1	1.0	0.3	0.3	0.8	-0.6	0.4
Tense / ‘highly strung’	0.4	0.7	4.3	-0.3	-2.1	-0.3	0.3	1.0	-0.0	0.0	-0.5	-1.0	0.8
Medication: Paracetamol	0.4	0.7	2.7	0.2	-1.6	-1.1	-0.2	0.0	-0.7	-0.6	-1.0	1.0	-0.4
Gout (self-reported)	0.4	0.5	1.3	-0.7	1.1	-0.5	0.3	-0.6	-1.1	-0.6	-0.3	1.0	-0.4
Arm fat-free mass (right)	0.4	2.0	6.1	-1.2	-0.8	-1.1	2.5	1.6	-1.0	-0.8	2.0	1.3	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.1	1.5	-1.1	0.0	-0.1	0.7	0.9	-0.0	0.0	-0.2	0.0
Arm predicted mass (right)	0.4	2.1	6.2	-1.1	-1.0	-1.3	2.5	1.5	-1.1	-0.8	2.1	1.2	1.1
Alcohol intake frequency.	0.4	1.0	3.1	0.8	-1.8	-1.0	1.1	1.1	-0.3	0.3	-0.0	0.4	1.6
Overall health rating	0.4	0.9	3.1	0.5	-1.8	-0.4	0.5	-0.1	0.4	1.4	0.2	0.6	1.7
Knee pain experienced in last month	0.4	0.6	2.1	1.1	-0.8	-0.1	0.1	1.1	-0.5	-1.4	0.0	-0.5	-0.8
Illnesses of father: Heart disease	0.4	0.6	1.9	-0.2	1.0	0.4	-0.7	-0.9	-0.1	-0.3	0.8	0.6	-1.4
Leg fat-free mass (right)	0.4	2.0	4.5	-2.1	0.0	-0.9	2.1	1.1	-1.3	-2.1	1.5	0.6	-0.1
Average weekly red wine intake	0.4	0.5	1.9	-1.0	-1.4	-0.6	-0.3	0.4	-0.4	-0.1	-0.5	-1.1	-0.4
Long-standing illness, disability or infirmity	0.4	0.6	2.0	1.4	-0.3	0.4	0.6	0.9	1.2	-0.0	0.2	0.9	0.8
Commuting to job workplace: Walk	0.4	0.5	1.6	0.5	0.3	0.5	0.2	1.3	0.6	-1.0	-1.1	0.1	0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.2	-0.9	-0.6	-0.9	0.2	0.8	-1.4	-1.5	-0.3	-0.1	-0.6
Breast cancer (self-reported)	0.4	0.5	2.3	-0.7	0.6	-0.2	-0.9	-0.6	-0.3	-0.5	-1.5	-0.4	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.7	2.9	0.2	-1.3	-1.4	-0.4	-0.0	-1.7	0.1	-0.1	-0.6	0.4
Leg predicted mass (right)	0.4	1.9	4.4	-2.0	-0.1	-0.9	2.1	1.1	-1.3	-2.1	1.5	0.6	-0.1
Number of self-reported non-cancer illnesses	0.4	0.7	2.6	0.9	-1.6	-0.7	0.0	0.5	-0.1	-0.5	-1.4	0.3	0.5
Financial situation satisfaction	0.4	0.5	1.4	0.7	0.1	-0.1	-0.2	-1.2	0.1	1.1	-0.3	-1.2	0.3
Commuting to job workplace: Public transport	0.4	0.4	1.2	-0.8	-1.0	0.1	0.7	0.3	0.3	0.1	1.1	0.6	0.6
Arm fat-free mass (left)	0.4	2.0	5.5	-1.2	-1.2	-1.5	2.4	1.5	-1.3	-1.0	1.7	0.4	1.0
Unable to work because of sickness or disability	0.4	0.5	1.4	1.2	0.4	0.7	-0.0	0.6	0.7	-0.9	-0.1	0.8	-0.8
Pain experienced in last month	0.4	0.7	2.0	-1.0	1.3	0.2	-1.4	-1.1	0.1	0.5	-0.6	0.1	-0.6
Crohns Disease (2017)	0.3	0.6	1.7	0.2	-0.6	1.0	-1.0	0.6	1.3	0.5	-0.1	-0.9	-0.7
Ulcerative Colitis (UC)	0.3	0.5	2.1	0.6	-0.7	-0.1	0.4	-0.1	0.3	1.2	1.5	0.5	0.4
Reaction Time	0.3	0.6	1.2	0.7	-0.2	0.6	0.4	0.9	0.8	-0.4	-1.0	-1.1	0.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	-0.9	-0.1	-0.2	-0.9	-0.8	-0.3	-0.1	-0.9	-0.4	-1.0
Neuroticism (2016)	0.3	0.4	1.8	-0.2	-1.3	-0.5	0.1	1.0	-0.5	-1.0	-0.2	0.2	-0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	3.0	0.0	-0.6	-0.3	-0.0	1.3	0.6	0.0	0.5	1.7	0.5
Lung FVC	0.3	1.8	5.6	-1.6	-2.4	-1.5	1.4	0.5	-1.7	-0.6	-0.3	-0.1	1.2
Relative age of first facial hair	0.3	0.7	1.7	-0.7	0.2	0.1	1.2	1.3	-0.4	-1.1	0.8	1.0	0.2
Diabetes (father)	0.3	0.3	1.1	0.0	0.8	0.5	-0.8	-0.3	0.5	1.1	-0.2	0.0	0.7
Leg fat-free mass (left)	0.3	1.4	3.9	-2.0	0.1	-0.7	1.7	0.8	-1.0	-1.8	1.4	0.2	-0.1
Serious illness, injury or assault to yourself	0.3	0.4	1.3	0.6	0.2	0.4	0.4	0.4	0.4	0.5	0.3	1.1	1.0
Leg predicted mass (left)	0.3	1.4	3.8	-1.9	0.1	-0.7	1.8	0.8	-1.0	-1.7	1.5	0.1	-0.0
Alcohol usually taken with meals	0.3	0.4	1.5	-0.1	-0.7	-0.2	0.9	0.6	-0.4	-0.8	-0.0	-1.2	0.1
Allergy	0.3	0.6	1.9	0.0	-1.2	-1.4	0.1	0.4	-1.0	-0.6	-0.7	-0.8	0.0
Neuroticism score	0.3	0.6	2.6	0.1	-1.2	0.3	0.5	0.7	0.6	0.7	0.6	-0.3	1.6
Trunk fat-free mass	0.3	1.9	4.8	-1.8	0.1	-0.8	2.1	1.2	-1.1	-1.3	2.2	0.7	0.4
Worrier / anxious feelings	0.3	0.6	1.9	-0.7	-1.4	-0.9	-0.4	-0.2	-0.6	1.0	0.4	-0.2	0.8
Medication: Lansoprazole	0.3	0.3	1.2	0.5	0.1	0.4	-0.1	0.4	0.3	-0.1	-0.2	1.1	1.1
Trunk predicted mass	0.3	1.9	5.3	-1.8	0.1	-0.8	2.2	1.3	-1.1	-1.2	2.3	0.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.8	1.4	-0.3	0.5	-0.3	0.7	0.5	0.7	-0.5	0.3	0.5
Loud music exposure frequency	0.3	0.3	0.8	-0.3	0.7	0.2	0.4	-0.0	0.0	0.5	0.5	0.9	0.9
Number of full brothers	0.3	0.3	0.8	0.9	-0.6	-0.4	0.3	0.8	-0.6	0.1	-0.2	0.7	0.6
Qualifications: College or University degree	0.3	0.9	2.1	-1.5	-0.9	-0.2	-1.1	-1.3	-0.2	0.8	0.5	-1.0	-1.2
Neck or shoulder pain in last month	0.3	0.4	1.6	0.3	-0.9	0.9	0.3	1.3	0.5	-0.4	-0.2	-0.1	0.5
Whole body fat mass	0.3	1.3	5.4	0.8	-2.3	-1.3	0.3	0.4	-0.2	0.2	-0.8	-1.5	1.5
Leg fat mass (right)	0.3	1.2	4.5	1.1	-2.1	-1.1	0.5	0.6	-0.0	0.5	-0.3	-1.4	1.6
Pulse rate, automated reading	0.3	0.9	2.3	0.0	-0.3	-0.9	1.2	0.7	-1.4	-0.9	1.1	-1.5	0.1
Whole body fat-free mass	0.3	1.8	4.3	-1.9	-0.1	-0.9	2.1	1.1	-1.2	-1.6	1.9	0.5	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	2.0	0.2	0.5	-0.0	-0.5	-0.7	-0.2	0.3	-0.0	-1.4	-0.2
Whole body water mass	0.3	1.9	5.2	-2.0	-0.0	-0.8	2.3	1.2	-1.2	-1.6	2.0	0.5	0.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.2	-0.2	-1.1	-0.9	-0.6	-0.2	-0.8	0.3	-0.2	0.2	-0.1
Medication: Paracetamol	0.3	0.4	1.8	0.3	-0.7	-1.0	0.4	-0.1	-0.6	-0.5	-0.5	1.3	0.0
Basal metabolic rate	0.3	1.4	3.2	-1.7	-0.4	-1.1	1.8	1.0	-1.2	-1.4	1.4	0.1	0.3
Risk taking	0.3	0.4	1.5	-0.6	-0.3	0.0	0.2	0.1	-0.3	-1.0	-1.2	1.2	0.1
Fractured/broken bones in last 5 years	0.3	0.4	1.5	-0.6	-0.2	-0.5	0.6	0.8	-0.3	-0.4	0.3	1.2	0.9
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	-0.7	-0.5	0.7	0.3	0.5	1.1	0.0	-0.2	-0.8	0.7
Leg fat mass (left)	0.3	1.2	3.9	1.1	-2.0	-1.0	0.8	0.8	-0.0	0.4	-0.2	-1.1	1.7
Arm predicted mass (left)	0.3	1.7	5.6	-1.3	-0.5	-1.0	2.4	1.3	-1.0	-0.8	1.9	0.6	1.1
Bipolar Disorder or Schizophrenia	0.2	0.4	1.1	0.2	-0.9	0.2	-0.6	-0.9	0.5	0.7	-1.1	-0.5	0.1
Schizophrenia (2018)	0.2	0.5	2.1	-0.3	-0.1	0.9	-0.5	-0.8	0.9	1.5	-0.3	-0.2	0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.5	-0.5	-0.9	0.1	0.6	-0.8	-0.6	0.0	-0.9	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.7	0.8	0.5	0.2	-0.8	-0.3	-0.1	0.0	0.3	0.9	-1.3
HDL Cholesterol	0.2	0.3	0.8	-0.3	0.1	-0.5	-0.3	-0.6	-0.7	-0.5	0.9	0.1	-0.9
Rheumatoid Arthritis	0.2	0.2	0.7	0.7	-0.0	0.2	0.1	0.6	0.2	0.5	0.2	0.6	0.8
Schizophrenia (2014)	0.2	0.5	1.2	-0.6	-0.2	0.5	-0.4	-0.9	0.5	0.6	-1.0	-1.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.9	0.4	-0.9	-0.8	0.1	0.4	-0.3	0.3	0.1	0.8	0.0
Ulcerative Colitis	0.2	0.3	0.8	-0.0	-0.3	0.4	0.2	0.0	0.4	0.9	0.4	-0.9	0.7
Blood Platelet Count	0.2	2.3	8.6	1.1	-2.9	-1.5	1.6	0.1	-0.3	1.2	2.5	-0.7	0.5
Height	0.2	4.5	16.6	-1.1	0.0	-2.0	-4.1	-3.0	-2.3	1.1	-0.7	-1.1	-2.5
Allergy or Eczema	0.2	0.5	1.2	-0.9	0.9	0.9	-0.5	-0.7	0.1	-0.6	-0.6	-0.4	-1.1
Average weekly spirits intake	0.2	0.2	0.8	-0.3	0.4	0.1	0.5	0.1	0.1	-0.6	-0.0	-0.9	-0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.9	0.2	-0.5	-0.1	-1.0	-0.0	-0.1	0.3	-0.0	0.5	-0.4
Medication: Co-codamol	0.2	0.2	0.7	0.3	0.4	0.5	-0.3	-0.2	0.8	0.5	-0.6	-0.6	0.1
Pack years adult smoking proportion	0.2	0.3	1.4	-1.2	-0.1	-0.2	-0.3	0.1	0.5	0.5	-0.1	0.4	0.6
Supplements: Glucosamine	0.2	0.3	0.8	-0.5	0.3	-0.6	0.7	-0.5	-0.9	-0.6	-0.2	-0.4	0.3
Sitting height	0.2	1.5	4.2	-0.9	0.2	-1.4	-1.2	-0.8	-2.0	-1.4	0.1	-0.2	-2.0
Fluid intelligence score	0.2	0.5	1.8	-0.0	-0.2	-0.6	-1.3	-0.5	-0.8	-0.4	-0.1	0.1	-1.3
Weight	0.2	1.1	2.6	-0.4	-1.6	-1.4	1.3	0.9	-0.8	-0.8	0.4	-0.9	1.0
Arm fat percentage (right)	0.2	0.9	3.0	0.9	-1.2	-0.1	0.6	0.8	0.6	-0.3	-0.8	-1.7	1.3
Hip circumference	0.2	1.0	4.2	-0.3	-2.0	-1.4	0.5	0.3	-0.6	-0.6	-0.5	-1.2	0.6
Alcohol intake versus 10 years previously	0.2	0.3	1.0	-0.3	1.0	0.4	-0.0	0.3	0.0	-0.5	-0.5	0.7	-0.6
Arm fat mass (right)	0.2	0.7	1.7	0.2	-1.3	-0.6	1.1	0.7	0.1	-0.5	-0.2	-1.3	1.3
Breastfed as a baby	0.2	0.3	0.8	0.1	0.9	-0.5	0.5	-0.7	-0.7	0.2	-0.5	0.4	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.3	0.4	0.6	0.6	1.1	0.3	0.4	0.0	0.5	-0.3	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.6	1.3	0.1	-0.3	0.9	0.3	-0.4	-1.1	0.4	-0.2	-0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	1.3	-1.1	1.0	0.0	0.2	-0.2	-0.3	-0.3	0.1	-0.7	-0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	-0.2	0.9	-0.2	-0.0	-0.9	-0.2	0.4	0.3	-0.5	-0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.9	-0.4	-0.7	-0.3	-0.1	-0.2	-0.1	-0.2	-0.5	-1.0	-0.4
Arm fat percentage (left)	0.2	0.9	2.3	0.9	-1.4	-0.1	0.5	0.6	0.8	0.0	-0.8	-1.5	1.4
Mood swings	0.2	0.3	1.7	0.4	-1.3	-0.6	-0.3	0.2	-0.2	0.3	-0.1	-0.3	0.7
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	-0.5	-0.2	0.2	0.7	0.6	0.7	0.3	0.3	0.0	0.9
Arm fat mass (left)	0.2	0.7	2.3	0.3	-1.4	-0.5	1.1	0.8	0.3	-0.0	0.0	-0.9	1.5
Average weekly champagne plus white wine intake	0.2	0.3	1.3	-0.4	-0.4	-0.5	-0.4	0.3	-0.5	-1.1	0.1	-0.7	-0.5
Age started oral contraceptive pill	0.2	0.3	0.8	0.1	-0.9	-0.0	0.3	0.5	0.2	-0.3	-0.2	-0.6	0.9
Pack years of smoking	0.2	0.2	0.6	-0.8	-0.5	-0.4	-0.2	0.3	0.4	0.5	0.1	0.1	0.8
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	0.9	0.8	0.7	0.1	-0.2	0.5	-0.1	0.9	0.5	-0.6
Irritable Bowel Disease (IBD)	0.1	0.3	1.0	0.3	-0.7	0.5	-0.2	0.2	0.8	1.0	0.7	-0.4	-0.3
BMI	0.1	0.4	1.3	-0.4	-1.1	-0.2	0.6	0.5	0.5	-0.1	-0.1	-0.3	1.1
Smoking Status	0.1	0.3	1.8	0.3	-0.0	0.3	-0.6	0.1	0.3	0.7	-0.5	1.4	0.3
Hypothyroidism (self reported)	0.1	0.3	1.3	1.1	0.6	-0.1	-0.1	-0.5	-0.4	-0.5	0.1	0.2	-0.7
Tanning	0.1	1.2	5.6	2.4	1.1	1.0	1.1	1.2	0.7	0.1	0.1	-0.2	1.1
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.4	-0.7	-0.4	0.7	0.0	-0.4	-0.6	0.3	-0.0	0.7
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.1	-0.4	0.8	0.5	-0.6	-1.1	-0.0	0.2	0.0	0.4	-0.7
Peak expiratory flow (PEF)	0.1	0.3	1.2	-0.5	-0.4	-0.8	-0.5	-0.1	-1.1	-0.4	-0.3	-0.2	-0.6
Comparative height size at age 10	0.1	0.7	2.4	-0.8	-0.6	-1.5	-0.3	-0.4	-1.3	-0.1	-0.3	-1.4	-0.4
Medication: Gliclazide	0.1	0.2	1.1	0.0	-0.0	-0.1	0.3	0.2	0.4	0.1	-0.1	1.0	0.4
Average weekly beer plus cider intake	0.1	0.2	0.5	-0.1	0.4	0.4	-0.0	0.3	0.6	0.3	-0.7	0.6	0.1
Irritability	0.1	0.2	0.9	-0.7	-0.4	-0.2	0.5	0.0	-0.4	-0.2	-0.5	-0.9	0.1
Hair Pigment	0.0	0.4	1.7	-0.1	-0.3	0.7	-0.0	0.0	0.7	-1.2	-0.3	-1.3	-0.1

Hub : Genes

CYP2C8

Models

Trait associations