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chr11:60,367,659-62,605,067

Best TWAS P=8.55e-63 · Best GWAS P=4.74e-62 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	16.5	16.7	8.6e-63	0.98	0.01	0.98	TRUE
56	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	16.2	15.4	7.8e-54	0.91	0.02	0.85	TRUE
11	GTEx	Breast Mammary Tissue (Female)	TMEM258	0.20	0.02	lasso	7	0.00	2.3e-01	10.3	12.0	2.1e-33	0.79	0.04	0.55	TRUE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf10	0.02	0.01	enet	11	0.01	1.6e-02	15.8	12.0	3.3e-33	0.78	0.01	0.78	TRUE
20	GTEx	Heart Left Ventricle	FADS2	0.17	0.12	enet	3	0.13	1.5e-07	10.9	11.8	2.8e-32	0.73	0.19	0.80	TRUE
36	METSIM	Adipose	MYRF	0.08	0.06	lasso	1	0.06	2.4e-09	-8.1	8.1	7.3e-16	0.30	1.00	0.00	TRUE
28	GTEx	Testis	DAGLA	0.26	0.16	enet	11	0.09	1.1e-04	-8.2	7.5	7.5e-14	0.27	0.54	0.05	TRUE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPLP0P2	0.03	0.04	enet	4	0.04	2.2e-08	-5.7	-6.3	2.7e-10	-0.10	0.90	0.10	TRUE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PGA3	0.21	0.13	enet	2	0.13	3.1e-14	-5.1	5.5	3.1e-08	0.07	0.00	1.00	TRUE
41	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	16.6	-16.5	3.7e-61	-0.95	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	15.3	16.4	1.1e-60	0.95	0.02	0.75	FALSE
9	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	15.8	-16.3	7.5e-60	-0.92	0.02	0.92	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	16.2	16.3	1.0e-59	0.96	0.05	0.95	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	16.2	-16.3	1.4e-59	-0.97	0.04	0.96	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	15.8	16.3	2.0e-59	0.92	0.15	0.85	FALSE
24	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	15.8	-16.1	3.7e-58	-0.91	0.16	0.83	FALSE
8	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	15.8	-15.9	4.0e-57	-0.91	0.08	0.92	FALSE
38	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	15.8	15.5	2.6e-54	0.91	0.09	0.91	FALSE
21	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	16.2	15.3	1.0e-52	0.93	0.04	0.95	FALSE
46	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	15.8	-14.4	4.5e-47	-0.81	0.02	0.64	FALSE
5	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	15.8	14.4	5.8e-47	0.79	0.04	0.91	FALSE
13	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	15.8	14.3	2.0e-46	0.77	0.35	0.62	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	15.3	-13.9	4.4e-44	-0.87	0.03	0.96	FALSE
54	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FADS1	0.20	0.01	blup	51	0.07	3.2e-04	16.6	-13.6	3.9e-42	-0.85	0.01	0.97	FALSE
17	GTEx	Esophagus Mucosa	FADS1	0.11	0.00	lasso	4	0.02	1.9e-02	15.8	-13.6	7.6e-42	-0.85	0.06	0.79	FALSE
42	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	9.4	13.3	1.3e-40	0.77	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	9.4	13.0	9.9e-39	0.78	0.65	0.35	FALSE
15	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	9.4	12.8	1.5e-37	0.75	0.08	0.92	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	9.4	12.6	3.0e-36	0.75	0.64	0.36	FALSE
10	GTEx	Brain Putamen basal ganglia	FADS1	0.29	0.21	enet	30	0.16	1.4e-04	16.2	-12.6	3.1e-36	-0.76	0.04	0.85	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS1	0.06	0.04	blup	53	0.03	2.0e-04	15.8	-12.5	6.2e-36	-0.68	0.08	0.42	FALSE
67	The Cancer Genome Atlas	Stomach Adenocarcinoma	FADS2	0.15	0.05	blup	71	0.11	2.5e-08	9.4	12.1	1.3e-33	0.72	0.02	0.98	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	9.4	11.9	1.1e-32	0.73	1.00	0.00	FALSE
26	GTEx	Spleen	FADS2	0.30	0.27	lasso	3	0.27	1.6e-07	9.4	11.8	4.3e-32	0.72	0.18	0.80	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	FADS2	0.30	0.33	lasso	8	0.33	5.6e-33	9.4	11.7	1.4e-31	0.71	1.00	0.00	FALSE
18	GTEx	Esophagus Muscularis	FADS2	0.32	0.30	lasso	6	0.31	3.7e-19	9.4	11.6	6.4e-31	0.71	1.00	0.00	FALSE
4	GTEx	Artery Aorta	FADS2	0.18	0.17	lasso	3	0.14	3.2e-08	9.4	11.2	3.6e-29	0.69	0.54	0.45	FALSE
64	The Cancer Genome Atlas	Rectum Adenocarcinoma	FADS2	0.47	0.34	lasso	5	0.30	7.9e-08	9.4	11.2	3.8e-29	0.69	0.03	0.95	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FADS2	0.05	0.04	lasso	3	0.05	1.9e-06	9.4	11.1	1.0e-28	0.71	0.33	0.59	FALSE
30	GTEx	Uterus	PPP1R32	0.66	-0.01	lasso	13	0.14	8.8e-04	-1.3	10.4	2.3e-25	0.59	0.02	0.51	FALSE
39	NTR	Blood	FADS2	0.30	0.33	lasso	7	0.33	9.0e-109	9.4	10.3	8.2e-25	0.64	1.00	0.00	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS2	0.07	0.07	lasso	4	0.06	1.9e-06	9.4	10.2	1.6e-24	0.70	0.12	0.87	FALSE
37	METSIM	Adipose	TMEM258	0.04	0.00	bslmm	407	0.01	4.1e-02	15.8	10.0	9.9e-24	0.66	0.02	0.89	FALSE
32	GTEx	Whole Blood	FADS2	0.49	0.48	lasso	5	0.48	3.0e-49	9.4	9.8	1.5e-22	0.61	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	FADS2	0.20	0.23	lasso	3	0.23	4.6e-17	9.4	9.7	2.4e-22	0.60	1.00	0.00	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	FADS2	0.04	0.04	lasso	4	0.02	1.7e-03	9.4	9.6	5.8e-22	0.62	0.07	0.74	FALSE
23	GTEx	Nerve Tibial	FADS2	0.20	0.14	lasso	3	0.13	1.5e-09	9.4	9.6	8.4e-22	0.60	0.86	0.14	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	FADS2	0.22	0.22	lasso	2	0.20	7.8e-08	9.4	9.5	2.1e-21	0.58	0.38	0.50	FALSE
29	GTEx	Thyroid	FADS2	0.16	0.18	lasso	4	0.17	7.0e-13	9.4	9.4	3.4e-21	0.59	1.00	0.00	FALSE
19	GTEx	Heart Atrial Appendage	FADS2	0.16	0.11	lasso	1	0.04	5.1e-03	9.4	9.4	4.0e-21	0.59	0.13	0.73	FALSE
58	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FADS2	0.15	0.16	lasso	2	0.12	8.8e-06	9.4	9.1	6.3e-20	0.60	0.46	0.33	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS2	0.05	0.04	lasso	2	0.04	2.2e-09	9.4	9.0	2.8e-19	0.57	0.98	0.02	FALSE
14	GTEx	Colon Sigmoid	FADS2	0.24	0.12	lasso	5	0.13	2.2e-05	6.2	8.9	3.6e-19	0.56	0.05	0.87	FALSE
35	METSIM	Adipose	FADS2	0.07	0.05	lasso	3	0.04	3.2e-07	9.4	8.7	4.1e-18	0.56	0.97	0.01	FALSE
25	GTEx	Spleen	MYRF	0.23	0.00	lasso	4	-0.01	4.6e-01	8.1	8.5	1.6e-17	0.52	0.04	0.30	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS1	0.04	0.00	blup	53	0.01	1.4e-03	3.1	-8.5	2.5e-17	-0.62	0.02	0.41	FALSE
22	GTEx	Nerve Tibial	DAGLA	0.13	0.07	lasso	4	0.06	7.6e-05	-8.2	8.1	7.2e-16	0.27	0.18	0.03	FALSE
66	The Cancer Genome Atlas	Soft Tissue Sarcoma	C11orf9	0.08	0.01	enet	11	0.03	1.0e-02	5.7	7.0	2.7e-12	0.22	0.04	0.04	FALSE
3	GTEx	Adrenal Gland	INCENP	0.23	0.05	lasso	3	0.03	3.8e-02	-6.3	-6.7	1.9e-11	-0.42	0.08	0.06	FALSE
27	GTEx	Spleen	LRRC10B	0.34	0.05	lasso	5	0.06	1.3e-02	5.7	-6.2	7.3e-10	-0.13	0.05	0.05	FALSE
33	GTEx	Whole Blood	SDHAF2	0.11	0.05	enet	43	0.05	2.7e-05	3.4	6.1	1.1e-09	0.18	0.85	0.01	FALSE
59	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RAB3IL1	0.11	0.01	blup	68	0.04	1.4e-02	8.4	-6.0	1.6e-09	-0.36	0.02	0.38	FALSE
7	GTEx	Artery Tibial	FADS1	0.09	0.00	enet	29	0.01	7.0e-02	-2.2	-6.0	2.7e-09	-0.44	0.07	0.35	FALSE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RPLP0P2	0.03	0.04	lasso	2	0.03	3.2e-04	-5.7	-5.7	9.7e-09	-0.08	0.06	0.84	FALSE
31	GTEx	Whole Blood	MYRF	0.17	0.03	lasso	5	0.04	2.4e-04	-8.2	5.5	3.7e-08	0.17	0.53	0.02	FALSE
65	The Cancer Genome Atlas	Rectum Adenocarcinoma	PGA3	0.35	0.02	enet	9	0.11	1.6e-03	-5.1	5.4	5.5e-08	0.05	0.00	0.26	FALSE
34	METSIM	Adipose	DDB1	0.05	0.04	lasso	2	0.02	1.3e-04	-5.1	5.2	1.9e-07	0.06	0.79	0.01	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	PGA3	0.09	0.03	blup	13	0.03	7.0e-04	-5.1	5.2	2.0e-07	0.07	0.00	0.64	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	PGA3	0.03	0.04	lasso	2	0.03	1.3e-04	-5.1	5.2	2.4e-07	0.06	0.00	0.94	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	PGA3	0.16	0.10	lasso	4	0.10	1.0e-09	-5.1	5.1	2.9e-07	0.06	0.00	1.00	FALSE