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chr12:10,000,986-11,287,271

Best TWAS P=6.9e-15 · Best GWAS P=3.53e-16 conditioned to 0.00833

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KLRC2	0.60	0.51	enet	19	0.66	5.4e-107	-8.2	-6.5	1.1e-10	0.87	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KLRC3	0.19	0.16	lasso	7	0.14	4.8e-17	-7.5	-7.5	4.5e-14	0.88	0.14	0.86	FALSE
3	METSIM	Adipose	KLRK1	0.09	0.06	bslmm	512	0.06	1.6e-09	-6.8	-6.9	5.5e-12	0.82	0.33	0.67	FALSE
4	NTR	Blood	KLRC1	0.03	0.01	lasso	5	0.02	4.8e-08	-8.1	-6.3	2.2e-10	0.77	0.00	1.00	FALSE
5	NTR	Blood	KLRC3	0.13	0.15	lasso	6	0.16	3.7e-50	-5.8	-6.8	7.6e-12	0.74	1.00	0.00	FALSE
6	ROSMAP	Brain Pre-frontal Cortex	KLRC2	0.62	0.47	bslmm	439	0.63	1.8e-104	-8.2	-6.3	2.5e-10	0.86	0.00	1.00	FALSE
7	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KLRC1	0.15	0.08	enet	12	0.12	1.9e-10	-7.5	-6.6	3.4e-11	0.81	0.01	0.99	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	KLRC1	0.05	0.03	blup	31	0.05	2.2e-11	-7.4	-7.8	8.9e-15	0.90	0.02	0.98	FALSE
9	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KLRC1	0.02	0.00	enet	5	0.00	9.6e-02	-5.7	-6.2	7.7e-10	0.65	0.02	0.57	FALSE
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KLRC1	0.05	0.08	blup	31	0.08	6.2e-09	-7.4	-7.8	6.9e-15	0.90	0.04	0.96	TRUE
11	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KLRC3	0.12	0.05	lasso	4	0.07	8.6e-09	-5.2	-5.4	5.9e-08	0.52	0.99	0.01	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	KLRC1	0.06	0.00	blup	31	0.04	1.0e-05	-8.2	-5.7	1.2e-08	0.71	0.00	0.97	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	KLRC4	0.05	0.04	lasso	2	0.04	2.9e-05	-7.4	-7.5	5.0e-14	0.89	0.00	0.99	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	KLRK1	0.04	0.02	lasso	4	0.03	8.2e-05	-5.9	-7.3	2.2e-13	0.79	0.05	0.87	FALSE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	KLRC1	0.03	0.01	blup	31	0.04	2.8e-05	-7.4	-7.8	8.1e-15	0.87	0.01	0.98	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	KLRC4	0.09	0.05	lasso	2	0.04	3.2e-05	-5.7	5.7	9.2e-09	-0.58	0.48	0.14	FALSE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KLRC1	0.03	0.02	blup	31	0.03	3.1e-04	-5.2	-6.4	1.8e-10	0.67	0.11	0.32	FALSE
18	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KLRC4	0.06	0.01	blup	41	0.02	6.1e-03	-5.8	6.8	1.5e-11	-0.73	0.02	0.35	FALSE
19	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	KLRC1	0.04	0.05	lasso	2	0.03	2.6e-03	-5.8	-5.8	7.3e-09	0.57	0.05	0.26	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	KLRC2	0.09	0.10	lasso	1	0.09	1.1e-04	-5.2	5.2	2.4e-07	-0.54	0.12	0.07	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	KLRC1	0.08	0.09	enet	8	0.10	2.9e-10	-5.2	-6.7	1.6e-11	0.72	0.73	0.27	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	KLRC4	0.06	0.05	blup	41	0.06	4.4e-05	-5.2	5.3	1.5e-07	-0.58	0.20	0.27	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	KLRC4	0.07	0.02	blup	41	0.05	1.6e-05	-5.8	5.5	4.6e-08	-0.56	0.32	0.31	FALSE