TWAS hub - KLRC3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.194	0.0390	5.2e-11	0.158	0.119	0.129	0.139	0.143	8.3e-19	2.7e-14	1.7e-15	1.3e-16	4.8e-17
2	NTR	Blood	0.127	0.0197	0.0e+00	0.153	0.131	0.159	0.153	0.163	7.2e-47	4.1e-40	8.8e-49	5.9e-47	3.7e-50
3	TCGA	Colon Adenocarcinoma	0.237	0.0860	1.7e-04	0.081	0.083	0.083	NA	0.072	2.0e-05	1.7e-05	1.6e-05	NA	5.6e-05
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.036	0.0251	5.5e-03	0.002	0.015	0.012	NA	0.009	1.7e-01	6.4e-03	1.3e-02	NA	2.8e-02
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.119	0.0522	2.9e-08	0.049	0.073	0.069	NA	0.075	3.0e-06	1.2e-08	3.6e-08	NA	8.6e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Medication: Bendroflumethiazide	5.1	7.7	12.6	1.8	3.3	1.9	2.8	3.6
Unable to work because of sickness or disability	4.4	5.7	8.6	-2.1	-2.9	-1.5	-2.3	-2.8
Number of children fathered	3.7	4.1	8.5	-0.7	-2.2	-2.9	-2.0	-1.7
Pulse wave reflection index	3.6	4.4	10.7	-0.7	2.0	1.3	3.3	2.2
Tinnitus: Yes, but not now, but have in the past	3.3	3.6	8.2	-1.0	1.5	1.7	2.9	1.9
Hearing difficulty/problems with background noise	3.3	5.2	13.5	0.5	-2.0	-3.7	-2.5	-1.5
Blood Red Count	3.2	31.3	56.9	-7.5	-6.8	-3.9	-2.9	-5.4
Bilateral oophorectomy (both ovaries removed)	3.2	3.6	5.6	-0.4	-2.2	-1.6	-2.4	-2.2
Falls in the last year	3.2	4.3	7.5	-1.9	-2.5	-0.6	-1.9	-2.7
Ever used hormone-replacement therapy (HRT)	3.1	4.0	8.4	0.3	-1.8	-1.7	-2.9	-2.3
Lung cancer (father)	3.1	3.6	6.0	-0.5	-2.0	-2.5	-2.1	-1.9
Loud music exposure frequency	3.1	3.4	7.9	-2.8	-2.2	-0.0	-1.1	-1.7
Bipolar Disorder (2011)	2.8	2.7	4.6	-2.0	-2.1	-0.6	-1.0	-1.9
Hearing difficulty/problems: Yes	2.5	3.7	6.1	-1.4	-2.3	-1.3	-1.9	-2.5
Ulcerative Colitis	2.4	3.4	7.4	-0.6	1.6	1.7	2.7	2.1
Alzheimer’s Disease (including proxy)	2.2	3.2	5.5	-2.3	-2.2	-0.6	-1.3	-1.9
Financial situation satisfaction	2.2	2.8	4.3	1.7	2.0	0.6	1.5	2.1
Had other major operations	2.1	2.6	4.3	-0.9	-1.9	-0.8	-1.9	-2.1
Illnesses of father: Heart disease	2.1	2.9	4.9	0.9	1.8	2.2	1.9	1.5
Leg fat percentage (right)	2.0	7.2	14.3	0.1	-2.7	-2.2	-3.8	-3.1
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	5.1	-2.3	-1.9	-1.7	0.0	-1.0
Blood Platelet Count	1.9	21.7	37.7	6.1	5.6	4.0	2.7	4.0
Illnesses of father: None of the above (group 1)	1.9	2.3	6.2	-0.3	-1.4	-2.5	-1.5	-1.0
Heart attack	1.8	2.2	4.8	-0.9	-1.9	0.2	-1.4	-2.2
Heart attack/myocardial infarction (self-reported)	1.8	2.4	5.0	-0.8	-1.9	0.1	-1.5	-2.2
Comparative body size at age 10	1.7	4.8	10.5	1.4	2.3	3.2	1.4	2.0
Medication for pain relief, constipation, heartburn	1.7	2.9	4.1	0.7	1.9	2.0	1.8	1.8
Number of full sisters	1.7	2.0	4.6	0.2	-1.3	-0.5	-2.1	-1.9
Leg fat percentage (left)	1.7	6.0	12.7	0.5	-2.4	-2.0	-3.6	-2.8
Mouth/teeth dental problems	1.6	2.4	5.7	-2.1	0.6	0.3	2.4	1.2
Mood swings	1.6	2.8	6.8	2.6	0.1	-0.4	-2.5	-1.0
Number of operations (self-reported)	1.6	2.4	4.1	-0.1	-1.6	-1.9	-2.0	-1.4
Heart disease (siblings)	1.6	2.0	3.7	-0.8	-1.8	-0.8	-1.3	-1.9
Allergy or Eczema	1.5	3.8	6.8	0.3	1.8	2.6	2.1	2.1
Supplements: Zinc	1.5	1.7	5.2	2.3	1.1	-0.5	0.1	1.2
Severe depression (siblings)	1.5	1.7	2.6	-0.7	-1.5	-1.2	-1.6	-1.1
Waist circumference	1.5	5.6	12.0	0.1	-2.3	-1.8	-3.5	-2.7
Medication: Co-codamol	1.4	1.7	2.9	1.5	1.4	1.7	0.6	1.0
Pulse rate	1.4	2.3	3.2	-0.9	-1.8	-1.4	-1.7	-1.6
Ever taken oral contraceptive pill	1.4	1.6	4.8	2.2	1.0	0.9	-1.1	0.1
Average weekly beer plus cider intake	1.4	2.0	3.8	0.3	1.4	0.9	2.0	1.9
Allergy	1.3	3.0	4.1	-0.6	-1.9	-2.0	-1.7	-1.9
Happiness	1.3	1.5	3.1	-0.6	0.9	1.5	1.8	1.2
Prospective memory result	1.3	1.5	3.9	-2.0	-1.5	-0.3	-0.3	-1.2
Medication: Ventolin 100micrograms inhaler	1.3	1.6	2.9	1.1	1.4	-0.2	1.4	1.7
Supplements: Calcium	1.3	1.5	2.2	1.3	1.3	-0.2	1.5	1.3
Ever had hysterectomy (womb removed)	1.2	1.4	2.6	1.6	-0.1	-1.6	-1.4	-0.3
Stomach or abdominal pain in last month	1.2	1.5	6.6	-0.2	-0.5	-2.6	-0.8	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	5.9	2.4	1.5	0.4	-0.2	1.1
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	4.0	-2.0	-1.7	-1.1	-0.9	-1.7
Smoking status: Previous	1.2	1.8	4.1	0.1	-1.0	-2.0	-1.6	-1.1
Guilty feelings	1.2	1.8	3.1	1.6	1.8	-0.3	0.6	1.6
Alcohol drinker status: Never	1.2	1.4	4.5	-2.1	-0.3	0.6	1.5	0.3
Cholesterol lowering medication	1.2	1.8	3.0	-1.1	-1.5	-1.0	-1.2	-1.7
Number of treatments/medications taken	1.1	1.9	3.6	1.2	-1.1	-1.2	-1.9	-1.3
Hayfever, allergic rhinitis or eczema	1.1	2.5	4.0	-0.0	1.5	2.0	1.9	1.6
Illnesses of siblings	1.1	1.5	2.2	1.2	1.5	1.0	0.8	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.3	-0.9	-1.1	-1.8	-1.0	-0.8
Depression (self-reported)	1.1	1.4	4.7	2.2	0.4	-0.3	-1.3	-0.3
Illnesses of mother	1.1	1.3	3.1	0.7	1.8	0.9	1.2	0.9
Eye problems/disorders: None of the above	1.1	1.3	3.4	-0.3	0.9	1.9	1.2	0.7
Leg pain on walking	1.1	1.4	5.2	-0.8	-1.1	-2.3	-0.3	-0.0
Schizophrenia (2018)	1.0	2.0	3.4	1.5	1.6	-0.6	1.1	1.8
Ulcerative Colitis (UC)	1.0	1.9	4.4	-0.0	1.2	-0.3	2.1	2.0
Multivitamins +/- minerals	1.0	1.3	3.0	1.7	1.4	0.0	0.6	1.0
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.0	0.6	1.1	1.4	0.8	1.2
Number of incorrect matches in round	1.0	1.7	2.6	-1.4	-1.6	-0.3	-1.4	-1.4
Hair/balding pattern: Pattern 3	1.0	1.5	3.2	1.8	1.7	0.5	0.2	1.1
Gout (self-reported)	1.0	1.4	5.5	0.9	0.8	2.3	-0.2	0.2
Migraine (self-reported)	1.0	1.2	3.6	-1.9	-0.6	1.3	0.3	-0.4
Leg fat mass (right)	1.0	4.0	10.1	0.5	-1.8	-1.0	-3.2	-2.4
Blood Eosinophil Count	0.9	6.7	10.2	3.2	3.2	0.6	2.2	2.9
Type 2 Diabetes (T2D) (2018)	0.9	1.6	5.7	2.4	0.9	0.8	-0.9	-0.1
Angina	0.9	1.2	1.8	-1.3	-1.1	1.4	-0.1	-1.2
Medication: Metformin	0.9	1.3	4.8	2.2	0.9	0.1	-0.8	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	2.3	0.6	1.2	0.9	1.5	1.5
Diabetes (self-reported)	0.9	1.4	5.0	2.2	1.1	0.7	-0.5	0.4
Arm fat percentage (right)	0.9	3.5	8.9	0.8	-1.7	-0.7	-3.0	-2.2
Body fat percentage	0.9	3.5	8.3	1.1	-1.5	-1.4	-2.9	-1.9
Emphysema/chronic bronchitis	0.9	1.0	1.7	1.3	1.3	0.3	0.5	1.1
Medication: Allopurinol	0.9	1.3	5.2	0.7	0.7	2.3	-0.1	-0.1
Pulse rate, automated reading	0.9	3.0	4.6	-0.2	-1.9	-1.8	-2.1	-1.9
Miserableness	0.9	1.5	3.0	1.7	1.5	0.7	0.2	1.2
Leg fat mass (left)	0.9	3.4	9.0	0.7	-1.6	-0.7	-3.0	-2.2
Depressed Affect (Nagel 2018)	0.8	1.8	6.3	2.5	1.3	-0.3	-0.7	0.6
Irritable Bowel Disease (IBD)	0.8	1.9	4.5	-0.1	1.2	0.0	2.1	1.9
Crohns Disease (2012)	0.8	1.3	2.8	-0.6	0.6	1.6	1.7	0.8
Triglycerides	0.8	1.3	2.3	1.1	1.5	0.4	1.0	1.5
Past tobacco smoking	0.8	1.5	4.1	-0.9	0.2	2.0	1.5	0.4
Alcohol usually taken with meals	0.8	1.3	1.9	-1.1	-1.2	-1.4	-0.4	-1.3
Hair/balding pattern: Pattern 4	0.8	1.9	5.2	-0.6	-1.5	-2.3	-1.0	-0.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.2	0.1	0.9	1.5	0.7	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.3	-0.8	0.3	0.6	1.5	1.0
Health satisfaction	0.8	1.0	2.2	-1.3	0.3	0.5	1.5	0.9
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.7	1.1	1.3	0.8	0.2	1.2
Angina (self-reported)	0.8	1.1	2.4	-1.2	-0.8	1.5	0.2	-0.9
Medication: Ibuprofen	0.8	1.0	1.6	-0.8	-1.0	-1.3	-0.9	-0.8
Medication: Seretide 50 evohaler	0.8	0.9	3.7	1.9	0.7	-0.1	-0.7	-0.1
Mean time to correctly identify matches	0.8	1.6	2.9	1.3	-0.5	-1.7	-1.4	-1.1
Medication: Aspirin	0.8	1.0	1.8	0.7	-0.8	-1.1	-1.3	-1.0
Supplements: Vitamin C	0.8	0.9	4.4	0.1	-0.2	-2.1	-0.3	-0.0
Smoking status: Current	0.8	1.3	2.0	1.3	1.4	1.2	0.6	1.0
Fractured/broken bones in last 5 years	0.8	1.0	2.7	0.3	-0.6	0.4	-1.6	-1.3
Myopia	0.8	1.1	2.1	1.5	1.0	1.2	0.3	0.9
Schizophrenia vs Biploar Disorder	0.7	1.0	3.7	1.9	0.7	-0.4	-0.6	0.5
Age at First Birth	0.7	1.0	2.1	-1.4	0.3	0.8	1.3	0.4
Primary Biliary Cirrhosis	0.7	1.0	2.2	0.7	1.5	0.3	0.9	1.2
Sensitivity / hurt feelings	0.7	1.1	3.0	0.5	-0.6	-1.1	-1.7	-0.9
Pack years adult smoking proportion	0.7	1.0	3.4	0.7	-0.7	0.3	-1.8	-0.9
Townsend deprivation index at recruitment	0.7	1.0	2.2	1.4	0.9	1.5	-0.4	-0.3
Current tobacco smoking	0.7	1.1	1.6	1.2	1.2	1.3	0.6	0.8
Relative age voice broke	0.7	1.0	2.3	-0.7	0.4	-1.5	1.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.6	-0.8	0.9	1.4	1.9	1.1
High blood pressure	0.7	2.1	4.5	2.1	-0.6	-1.1	-1.9	-0.8
Sitting height	0.7	4.9	8.0	0.6	2.5	1.7	2.8	2.7
Body mass index (BMI)	0.7	3.1	7.1	0.0	-1.7	-0.7	-2.7	-2.2
Qualifications: None of the above	0.7	1.5	2.9	-0.2	-1.3	-0.4	-1.7	-1.7
Mouth/teeth dental problems: Dentures	0.7	1.1	2.7	1.0	-0.9	0.1	-1.7	-1.1
Medication: Lansoprazole	0.7	0.8	2.1	-0.2	0.8	0.5	1.5	1.1
Breastfed as a baby	0.7	0.9	3.3	-1.8	-0.4	0.4	0.8	-0.2
Tense / ‘highly strung’	0.7	1.2	1.7	-1.0	-1.3	-0.9	-1.2	-1.0
Birth weight	0.7	1.6	2.9	-1.7	-1.6	0.8	-0.5	-1.2
Chest pain or discomfort	0.7	1.0	2.6	1.6	0.9	-0.1	0.2	1.2
Hypertension (Self-reported)	0.7	2.0	4.6	2.1	-0.5	-0.4	-2.0	-1.0
Arm fat percentage (left)	0.7	2.7	6.9	0.8	-1.4	-0.6	-2.6	-1.9
Osteoporosis (self-reported)	0.7	0.9	1.8	0.9	1.3	0.9	0.5	0.9
Medication: Aspirin	0.7	0.9	1.5	0.4	-0.9	-1.2	-1.1	-0.8
Number of self-reported non-cancer illnesses	0.7	1.1	2.3	1.3	-0.7	-0.7	-1.5	-0.8
Average weekly champagne plus white wine intake	0.7	0.9	3.9	0.6	-0.0	-2.0	-0.5	-0.0
Wears glasses or contact lenses	0.7	0.8	1.3	0.3	-0.9	-1.0	-1.1	-0.8
Alzheimer’s Disease (in father)	0.6	0.6	1.0	-1.0	-0.9	0.1	-0.6	-0.9
Reaction Time	0.6	1.1	3.2	1.2	0.1	-1.8	-0.6	-0.4
Ovarian Cancer	0.6	0.9	1.5	-0.1	-0.9	-1.1	-1.2	-0.9
Mean Putamen Volume	0.6	0.7	1.6	-0.6	-1.0	-0.0	-0.7	-1.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.8	-0.2	-0.6	-0.6	-1.4	-0.9
Diabetes (father)	0.6	0.7	1.7	-0.3	0.5	1.3	1.0	0.7
Maternal smoking around birth	0.6	0.9	2.3	1.4	0.3	-1.5	-0.5	0.3
Chronic bronchitis/emphysema (father)	0.6	0.7	2.3	0.5	0.7	1.5	0.2	0.6
Financial difficulties in last 2 years	0.6	0.8	2.5	1.6	0.5	0.5	-1.0	-0.1
Pain all over the body in last month	0.6	0.6	2.1	-0.3	0.0	1.5	1.0	0.0
Arm fat mass (right)	0.6	2.3	6.1	0.8	-1.2	-0.4	-2.5	-1.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	0.1	1.0	0.1	0.9	1.4
Forced vital capacity (FVC), Best measure	0.6	2.0	3.4	-0.3	1.4	1.8	1.8	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.5	1.0	-0.4	-0.4	-1.2	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.1	0.1	0.9	0.8	1.0	1.0
Whole body fat mass	0.6	2.4	6.5	1.2	-1.0	-0.9	-2.5	-1.6
Overall health rating	0.6	1.3	4.2	2.1	0.4	-0.5	-1.3	-0.2
Diabetes diagnosed by doctor	0.6	1.0	2.7	1.6	0.7	1.0	-0.7	0.1
Eye problems/disorders: Cataract	0.6	0.7	2.3	1.5	-0.3	-0.6	-0.9	-0.4
Medication: Gliclazide	0.6	0.7	2.3	1.5	0.6	0.3	-0.9	-0.2
Ever smoked	0.6	1.0	2.7	1.6	0.6	-0.9	-1.1	0.1
Diastolic blood pressure, automated reading	0.6	1.8	2.8	-1.4	-1.6	-0.2	-1.3	-1.7
Alzheimer’s Disease (in mother)	0.5	0.6	0.9	-0.9	-0.9	0.0	-0.8	-0.7
Coronary Artery Disease (CAD)	0.5	0.6	1.0	-1.0	-0.7	1.0	-0.0	-0.6
Fasting Glucose	0.5	0.6	1.3	-1.2	0.2	-0.0	0.9	0.9
Lupus	0.5	0.7	1.9	-0.2	-0.7	-1.4	-1.0	-0.2
Neuroticism (2016)	0.5	0.7	1.8	1.3	0.6	-0.4	-1.1	-0.1
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.1	-0.8	-1.0	-0.4	-0.4	-0.8
Waist Hip Ratio (WHR)	0.5	2.5	4.2	0.1	-1.7	-1.5	-2.0	-1.8
Respiratory disease	0.5	1.1	2.1	1.4	1.4	0.9	0.3	0.8
Trunk fat percentage	0.5	2.0	5.1	1.3	-0.9	-0.8	-2.2	-1.3
Fed-up feelings	0.5	0.9	2.6	1.6	0.6	-0.8	-0.9	0.1
Qualifications: CSEs or equivalent	0.5	0.6	1.4	0.6	1.2	0.3	0.8	0.9
Forced vital capacity (FVC)	0.5	1.8	2.5	0.6	1.5	1.3	1.6	1.4
Medication: Ramipril	0.5	0.7	2.3	1.5	0.6	0.4	0.4	0.7
Medication: Simvastatin	0.5	0.7	1.5	1.1	-0.1	-1.2	-0.9	-0.1
Noisy workplace	0.5	0.6	1.2	-1.1	-1.1	-0.3	-0.3	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.1	-0.7	0.9	2.0	1.5	0.7
Exposure to tobacco smoke at home	0.5	0.5	1.2	0.2	-0.5	0.0	-1.1	-1.1
Birth weight of first child	0.5	0.9	2.8	-1.7	-1.2	-0.1	0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	3.0	-1.7	-0.8	-0.1	0.3	-0.8
Neck or shoulder pain in last month	0.5	0.6	2.2	-0.6	-0.8	-1.5	0.1	-0.1
Heart disease (mother)	0.5	0.6	1.1	0.3	-0.8	-1.1	-0.9	-0.5
Illnesses of siblings: Diabetes	0.5	0.6	1.1	-0.8	-0.7	0.6	-0.3	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.0	1.4	0.7	0.0	-0.1	0.7
Qualifications: nursing, teaching	0.5	0.7	1.9	0.3	-0.9	-0.5	-1.4	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	-1.2	-0.3	0.8	0.9	-0.0
Breast cancer (self-reported)	0.5	0.6	1.4	-1.2	-0.2	-0.6	1.1	0.5
Arm fat mass (left)	0.5	2.0	5.2	0.8	-1.1	-0.5	-2.3	-1.7
Age started oral contraceptive pill	0.5	0.6	0.9	-0.3	-0.9	-0.9	-0.8	-0.7
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.9	-1.4	0.9	0.7	1.7	1.0
Pack years of smoking	0.5	0.8	2.4	0.9	-0.5	-0.0	-1.6	-0.6
Bipolar Disorder (2018)	0.4	0.6	1.8	-1.3	-0.8	-0.6	0.3	-0.4
Crohns Disease (2017)	0.4	0.9	1.9	0.0	0.9	0.6	1.4	1.1
Blood White Count	0.4	3.2	6.7	2.6	2.3	0.6	0.9	1.7
Systolic Blood Pressure	0.4	2.2	2.8	-1.3	-1.7	-1.5	-1.3	-1.6
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.3	0.5	0.7	1.1	0.2	0.8
Relative age of first facial hair	0.4	0.7	2.7	-0.5	0.1	-1.6	0.7	0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.8	-0.7	-0.2	1.3	0.1	-0.5
Systolic blood pressure, automated reading	0.4	1.3	2.2	-1.2	-1.5	-0.7	-0.7	-1.3
Vitamin and mineral supplements	0.4	0.5	0.7	-0.8	-0.8	0.7	-0.5	-0.7
Supplements: Glucosamine	0.4	0.5	1.2	0.3	0.4	1.1	0.5	0.9
Medication: Atenolol	0.4	0.5	2.0	1.4	0.5	-0.4	-0.2	0.3
Medication: Levothyroxine sodium	0.4	0.6	2.1	-1.4	-0.8	-0.6	-0.1	-0.5
High blood pressure (mother)	0.4	0.5	1.9	1.4	0.1	0.7	-0.6	-0.1
Trunk fat mass	0.4	1.9	5.1	1.2	-0.8	-0.6	-2.3	-1.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	-1.1	-0.9	-0.3	-0.2	-0.7
Neuroticism score	0.4	0.8	2.0	1.4	0.6	-1.0	-0.9	0.5
Hip circumference	0.4	1.9	4.7	0.1	-1.3	-0.7	-2.2	-1.6
Worrier / anxious feelings	0.4	0.7	1.2	1.0	0.6	-1.1	0.3	1.1
Asthma	0.4	0.8	1.4	0.3	1.1	0.3	1.2	1.1
Medication: Cholesterol lowering	0.4	0.7	2.0	1.4	0.3	-0.9	-0.4	0.5
Pulse wave Arterial Stiffness index	0.4	0.4	1.3	-1.2	0.1	0.4	0.7	0.2
Blood clot in the leg (DVT)	0.4	0.5	0.8	0.6	0.9	0.8	0.4	0.9
Number of full brothers	0.4	0.5	1.3	0.5	0.5	-1.1	0.5	0.6
Worry too long after embarrassment	0.4	0.6	2.5	0.5	-0.0	-1.6	-0.5	-0.0
Age at first live birth	0.4	0.7	1.2	-1.1	0.2	1.0	0.9	0.7
Pulse wave peak to peak time	0.4	0.5	1.3	1.1	-0.2	-0.6	-0.9	-0.2
Medication: Blood pressure	0.4	0.7	1.7	1.3	-0.0	0.6	-1.0	-0.7
Suffer from ‘nerves’	0.4	0.6	1.3	1.1	0.7	-0.4	-0.1	0.9
Had major operations	0.4	0.5	1.4	-1.2	-0.9	0.1	-0.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.5	1.2	0.0	-0.7	-0.2	0.2
Loneliness, isolation	0.4	0.6	1.1	1.0	0.6	-1.0	-0.4	0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.8	-0.1	-0.7	-1.3	-0.2	-0.1
Medication: Atorvastatin	0.4	0.5	1.8	1.4	0.3	0.1	-0.8	-0.3
Irritability	0.4	0.7	1.5	1.2	0.8	-0.6	-0.6	0.7
Risk taking	0.4	0.5	1.0	-0.4	-0.7	0.5	-1.0	-0.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	0.9	0.6	-0.3	0.5	1.0
Ever depressed for a whole week	0.4	0.5	1.1	-0.0	0.6	-0.5	1.0	1.0
Basal cell carcinoma (self-reported)	0.4	0.4	1.1	0.6	0.8	1.0	0.3	0.2
Bipolar Disorder or Schizophrenia	0.3	0.8	1.4	0.4	0.8	-0.9	1.0	1.2
Neuroticism (Nagel 2018)	0.3	0.8	1.9	1.4	0.9	-0.6	-0.3	0.7
Major Depression (MDD)	0.3	0.3	1.3	-1.1	0.1	0.1	0.5	0.3
Schizophrenia (2014)	0.3	0.6	1.1	0.7	0.7	-1.1	0.6	0.8
Smoking Status	0.3	0.7	1.8	0.9	-0.1	-0.6	-1.3	-0.7
Hand grip strength (left)	0.3	0.7	1.3	0.7	1.0	0.4	0.9	1.1
Hand grip strength (right)	0.3	0.7	1.2	0.2	1.0	0.6	1.1	1.0
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.8	0.5	0.9	-0.2	-0.2
Weight	0.3	1.3	3.4	0.4	-0.8	-0.6	-1.9	-1.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.4	-0.1	0.8	1.9	1.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.1	-0.6	0.2	-1.0	-0.7
Medication: Paracetamol	0.3	0.6	1.3	0.6	0.9	-0.1	0.6	1.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.8	-1.4	0.1	0.1	0.7	0.3
Glaucoma (self-reported)	0.3	0.4	0.8	0.5	-0.2	-0.9	-0.9	-0.3
Ever had bowel cancer screening	0.3	0.3	0.9	0.9	-0.1	-0.6	-0.6	0.1
Commuting to job workplace: Walk	0.3	0.3	0.5	0.5	-0.4	0.3	-0.7	-0.6
Asthma (self-reported)	0.3	0.6	1.1	0.4	1.1	0.3	0.9	1.0
Osteoarthritis (self-reported)	0.3	0.3	1.2	1.1	0.3	0.3	-0.2	0.5
Hearing aid user	0.3	0.4	1.2	-0.3	-0.0	-1.1	0.1	0.8
Eye problems/disorders: Glaucoma	0.3	0.4	0.6	-0.1	-0.8	-0.7	-0.7	-0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	-0.4	-0.5	-0.9	-0.7	-0.6
Medication: Lisinopril	0.3	0.4	0.9	0.4	-0.2	-0.8	-1.0	-0.3
Pain experienced in last month	0.3	0.5	1.4	1.2	0.6	0.8	-0.1	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	0.6	0.7	0.6	0.2	0.9
Alcohol drinker status: Previous	0.3	0.3	0.6	0.8	0.3	0.8	0.3	0.2
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	0.8	0.1	0.3	-0.6	-0.3
HbA1C	0.2	0.3	0.8	0.1	0.1	0.4	-0.9	-0.5
Rheumatoid Arthritis	0.2	0.2	0.8	0.4	0.3	-0.1	0.3	0.9
BMI	0.2	1.3	3.2	1.1	-0.6	-0.4	-1.8	-1.2
Cardiovascular Disease	0.2	0.8	2.2	1.5	-0.3	-0.5	-1.0	-0.5
Hypothyroidism (self reported)	0.2	0.5	1.6	-1.3	-0.6	0.0	0.0	-0.6
Lung FEV1/FVC ratio	0.2	0.9	1.7	-0.2	-0.8	1.3	-0.2	-1.3
Tanning	0.2	3.0	4.5	1.5	2.0	0.9	1.8	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.1	-0.5	-0.3	-0.9	-0.7
Taking other prescription medications	0.2	0.3	0.6	-0.0	-0.6	-0.8	-0.7	-0.4
Nervous feelings	0.2	0.4	1.3	-0.3	-0.6	-1.1	-0.5	-0.4
Had menopause	0.2	0.3	0.6	0.7	0.2	-0.8	0.1	0.3
Impedance of arm (right)	0.2	0.8	1.2	0.9	1.0	0.7	0.8	1.1
Number of live births	0.2	0.2	0.9	0.9	0.4	0.2	-0.1	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.6	-1.3	-0.4	-0.4	0.8	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.6	0.2	-0.2	-0.6	-0.2
Impedance of arm (left)	0.2	1.1	1.7	0.7	1.1	0.8	1.3	1.3
Standing height	0.2	1.8	3.1	0.6	1.7	0.5	1.6	1.8
Length of working week for main job	0.2	0.2	0.5	0.7	-0.0	-0.5	-0.6	-0.2
Medication: Amlodipine	0.2	0.3	0.6	0.4	-0.3	0.8	-0.5	-0.6
Shortness of breath walking on level ground	0.2	0.2	0.7	0.7	-0.0	-0.8	-0.2	0.0
Age at last live birth	0.2	0.3	0.6	-0.8	0.2	-0.2	0.5	0.7
Knee pain experienced in last month	0.2	0.3	1.4	-1.2	-0.3	-0.4	0.2	0.0
Average weekly red wine intake	0.2	0.4	1.1	-0.1	-0.6	-1.1	-0.5	-0.3
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.3	-0.5	-0.4	-0.8	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.1	1.0	-0.1	-0.1	-0.8	-0.3
Back pain experienced in last month	0.2	0.3	0.6	-0.3	0.6	0.0	0.7	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.4	-0.4	0.4	0.3	1.2	0.8
Mother’s age at death	0.2	0.3	0.7	-0.9	-0.5	-0.5	0.2	0.3
Medication: Blood pressure	0.2	0.4	0.6	0.7	0.7	0.1	0.6	0.8
High cholesterol (Self-reported)	0.2	0.4	0.7	0.7	-0.3	-0.6	-0.9	-0.6
Medication: Paracetamol	0.2	0.3	0.8	0.3	0.6	-0.3	0.3	0.9
Illnesses of father: High blood pressure	0.2	0.3	0.9	-0.6	0.2	0.4	1.0	0.1
Commuting to job workplace: Cycle	0.2	0.2	0.6	-0.4	0.2	0.8	0.5	0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.0	1.0	-0.1	-0.3	-0.3	-0.4
Depression (Nagel 2018)	0.1	0.2	0.5	0.7	0.5	0.0	-0.3	0.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.0	-0.5	-0.5	1.0	-0.4	-0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.9	-0.4	-0.0	1.0	0.5	0.1
HDL Cholesterol	0.1	0.1	0.3	-0.3	-0.3	0.5	-0.3	-0.3
Heel T-Score	0.1	0.8	2.9	-1.7	-0.6	0.1	0.8	0.1
Neuroticism	0.1	0.2	0.3	0.4	0.6	-0.5	-0.3	0.4
Chronotype (morning person)	0.1	0.3	0.6	0.8	0.5	0.7	0.4	0.3
Hair Pigment	0.1	1.5	5.6	2.4	0.8	-0.9	-0.4	0.4
Average weekly spirits intake	0.1	0.1	0.2	0.3	0.2	-0.4	0.1	0.4
Medication for hormone replacement therapy	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.2	-0.4
Impedance of leg (right)	0.1	0.3	1.2	0.1	-0.4	-1.1	-0.3	-0.1
Leg fat-free mass (left)	0.1	0.3	0.6	0.6	0.6	0.8	-0.2	0.1
Average weekly fortified wine intake	0.1	0.1	0.3	0.1	0.1	-0.1	0.5	0.6
Age when periods started (menarche)	0.1	0.3	1.0	0.7	0.2	-1.0	-0.1	0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.4	0.1	0.1	-0.1	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.4	-0.1	-0.6	0.2	0.0
Fluid intelligence score	0.1	0.2	0.9	-0.0	-0.1	1.0	0.0	-0.2
Time employed in main current job	0.1	0.1	0.2	-0.2	0.0	0.4	0.0	-0.3
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.4	0.0	0.4	-0.6	-0.3
Father’s age at death	0.1	0.2	0.3	-0.1	-0.5	0.1	-0.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.3	0.3	-0.1	0.2	0.5
Peak expiratory flow (PEF)	0.1	0.3	0.6	0.7	0.7	-0.0	0.4	0.5
Headache pain in last month	0.1	0.1	0.2	-0.4	-0.3	-0.4	-0.4	-0.3
High blood pressure (siblings)	0.1	0.2	0.7	0.8	0.1	-0.2	-0.4	-0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	-0.0	-0.1	-0.8	-0.4	-0.2
Qualifications: College or University degree	0.1	0.2	0.8	0.1	0.2	-0.2	0.9	0.4
Medication: Omeprazole	0.1	0.1	0.4	0.1	-0.3	0.5	0.0	-0.6
Comparative height size at age 10	0.1	0.4	1.2	1.1	0.7	-0.0	-0.1	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.4	-0.2	-0.3	-0.3	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.5	-0.0	-0.1	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	-0.7	0.0	0.7	0.3	-0.2
Leg fat-free mass (right)	0.1	0.5	1.0	0.8	0.9	1.0	-0.1	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.5	0.3	-0.1	-0.6	-0.1
Friendships satisfaction	0.1	0.1	0.5	0.2	-0.0	-0.7	-0.0	0.5
Medication for cholesterol	0.1	0.1	0.3	-0.2	-0.1	-0.5	-0.3	0.2
Mineral and other dietary supplements	0.1	0.1	0.6	-0.8	-0.1	-0.0	-0.2	-0.3
Leg predicted mass (right)	0.1	0.5	0.8	0.9	0.9	0.9	-0.1	0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.4	-0.3	-0.6	0.3	-0.2
Arm fat-free mass (left)	0.1	0.3	0.9	0.3	-0.2	-0.6	-0.9	-0.5
Impedance of whole body	0.1	0.4	0.8	0.7	0.6	-0.1	0.6	0.9
Arm predicted mass (left)	0.1	0.6	1.5	0.2	-0.5	-0.9	-1.2	-0.7
Worry (Nagel 2018)	0.0	0.0	0.2	0.0	0.1	-0.1	0.0	0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.1	0.2	-0.1	0.2	0.5	0.3	-0.0
Height	0.0	0.6	1.2	0.9	0.6	-1.1	0.2	0.7
Lung FVC	0.0	0.1	0.4	-0.6	-0.1	0.4	0.1	-0.2
Diabetes (mother)	0.0	0.0	0.1	-0.2	-0.2	0.3	-0.1	0.0
Impedance of leg (left)	0.0	0.2	0.6	0.8	0.1	-0.7	-0.2	0.2
Leg predicted mass (left)	0.0	0.3	0.6	0.6	0.5	0.8	-0.3	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	0.2	0.2	0.3	0.1	0.2
Trunk fat-free mass	0.0	0.0	0.1	0.2	0.1	0.1	-0.3	-0.2
Trunk predicted mass	0.0	0.0	0.1	0.1	0.1	0.0	-0.3	-0.2
Arm fat-free mass (right)	0.0	0.2	0.5	0.6	0.1	-0.3	-0.7	-0.2
Exposure to tobacco smoke outside home	0.0	0.0	0.1	-0.0	0.1	0.1	-0.1	0.3
Arm predicted mass (right)	0.0	0.2	0.6	0.8	0.5	-0.1	-0.3	0.1
Alcohol intake frequency.	0.0	0.1	0.2	-0.0	-0.3	-0.4	-0.5	-0.3
Family relationship satisfaction	0.0	0.1	0.2	-0.4	-0.0	0.2	0.1	0.1
Whole body fat-free mass	0.0	0.1	0.2	0.5	0.3	0.4	-0.5	-0.2
Whole body water mass	0.0	0.1	0.4	0.5	0.2	0.1	-0.6	-0.3
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.2	0.2	-0.1	0.1	0.0
Basal metabolic rate	0.0	0.2	0.4	0.5	0.1	0.2	-0.6	-0.3

Hub : Genes

KLRC3

Models

Trait associations