Hub : Genes

KLRC4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0464	0.0149	1.3e-05	0.040	0.017	0.033	0.036	0.036	7.7e-13	2.3e-06	6.9e-11	7.3e-12	7.3e-12
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0373	0.0252	3.4e-03	0.013	0.013	0.012	NA	0.015	1.2e-02	1.0e-02	1.5e-02	NA	7.0e-03
3	TCGA	Brain Lower Grade Glioma	0.0454	0.0231	1.3e-04	0.043	0.037	0.035	NA	0.039	1.2e-05	4.5e-05	6.4e-05	NA	2.9e-05
4	TCGA	Lung Adenocarcinoma	0.0887	0.0548	1.1e-04	0.046	0.030	0.017	NA	0.037	3.8e-06	1.9e-04	4.0e-03	NA	3.2e-05
5	TCGA	Lung Squamous Cell Carcinoma	0.0638	0.0537	6.7e-03	0.010	0.015	0.013	NA	0.010	2.6e-02	6.1e-03	1.2e-02	NA	2.4e-02
6	TCGA	Stomach Adenocarcinoma	0.0630	0.0400	3.5e-04	0.046	0.059	0.058	NA	0.058	2.9e-04	4.4e-05	5.0e-05	NA	5.3e-05
7	TCGA	Thyroid Carcinoma	0.0710	0.0420	4.1e-05	0.021	0.049	0.041	NA	0.039	3.3e-03	1.6e-05	6.5e-05	NA	1.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.4	1.4	-0.6	-0.1	-1.2	0.9	0.2	-0.1	0.1
Bipolar Disorder or Schizophrenia	0.4	1.0	1.8	-0.8	-1.1	0.1	-1.2	-0.9	-1.3	-1.1
Depressed Affect (Nagel 2018)	1.7	3.7	6.1	-2.5	-2.1	1.7	-1.6	-1.6	-1.4	-2.3
Depression (Nagel 2018)	0.7	1.1	3.8	-1.9	-1.4	0.5	-0.2	-0.7	-0.7	-0.8
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.4	-0.4	-0.3	0.2	0.6	-0.1	-0.1	-0.1
Neuroticism (Nagel 2018)	0.9	2.2	3.7	-1.9	-1.6	1.0	-1.4	-1.2	-1.2	-1.9
Schizophrenia (2018)	1.0	2.1	5.0	-0.6	-1.4	1.1	-2.2	-1.3	-1.6	-1.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.3	0.6	0.1	1.1	-0.9	-0.3	-0.0	0.1
Worry (Nagel 2018)	0.0	0.1	0.2	-0.4	-0.2	-0.1	-0.0	0.2	-0.2	-0.4
Alzheimer’s Disease (in mother)	0.8	1.0	1.7	0.8	0.9	-0.8	1.1	1.3	0.8	1.0
Alzheimer’s Disease (in father)	0.7	0.8	1.5	0.2	0.6	-0.8	1.2	0.9	0.9	1.1
Alzheimer’s Disease (including proxy)	2.4	3.5	5.2	0.9	1.6	-2.0	2.0	2.3	1.9	2.1
Crohns Disease (2017)	0.2	0.5	2.1	1.5	0.6	-0.1	-0.6	0.1	0.4	0.9
Irritable Bowel Disease (IBD)	0.2	0.4	1.9	1.0	0.0	-0.3	-1.4	0.2	-0.3	0.3
Ulcerative Colitis (UC)	0.2	0.5	2.2	0.3	-0.6	-0.1	-1.5	-0.1	-0.7	-0.3
Major Depression (MDD)	0.2	0.2	0.5	-0.3	-0.2	-0.7	-0.1	0.6	-0.5	-0.6
Reaction Time	0.2	0.3	0.8	-0.7	-0.3	-0.1	-0.9	-0.8	-0.1	-0.7
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.3	-0.2	-0.2	0.3	0.5	0.1	-0.2	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.4	0.5	1.5	0.3	0.8	-0.7	0.3	1.2	0.7	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.1	0.1	0.4	0.2	-0.4	-0.7	0.0	-0.1	-0.6	-0.2
Bipolar Disorder (2011)	1.9	1.9	4.0	-0.1	0.9	-1.6	2.0	1.0	1.6	1.6
Body Mass Index (BMI) (2010)	0.0	0.1	0.2	0.5	0.3	0.2	0.0	-0.0	0.1	-0.1
Coronary Artery Disease (CAD)	0.6	0.7	2.7	0.4	0.6	-0.2	1.6	0.4	0.6	1.1
Crohns Disease (2012)	0.2	0.4	1.4	1.2	0.3	0.1	0.4	-0.5	-0.2	0.7
Mean Putamen Volume	0.2	0.3	0.8	-0.2	0.3	-0.6	0.9	0.0	0.5	0.5
Fasting Glucose	0.2	0.3	0.7	0.9	0.1	-0.4	-0.7	0.6	0.4	0.3
HbA1C	0.4	0.5	0.8	-0.9	-0.7	0.7	0.0	-0.7	-0.7	-0.8
HDL Cholesterol	0.1	0.2	0.5	-0.0	0.5	0.2	0.7	-0.0	0.0	0.5
LDL Cholesterol	1.0	1.5	3.2	-1.8	-1.6	0.6	-0.2	-1.6	-1.0	-0.9
Lupus	0.6	0.9	3.1	0.8	0.9	-0.8	0.3	1.8	0.9	0.6
Neuroticism (2016)	0.8	1.1	1.8	-1.1	-0.8	1.2	-0.9	-1.3	-0.8	-1.0
Primary Biliary Cirrhosis	1.2	1.8	2.8	-1.3	-1.7	0.8	-1.3	-1.3	-1.2	-1.5
Rheumatoid Arthritis	0.2	0.2	0.7	0.2	-0.0	0.8	-0.3	0.0	-0.8	-0.5
Schizophrenia (2014)	0.2	0.4	1.6	0.0	-0.5	0.2	-1.3	-0.6	-0.5	-0.5
Triglycerides	0.6	0.9	2.0	0.0	-0.9	0.7	-1.4	-0.8	-1.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.8	0.6	0.8	-1.1	0.8	1.7	0.6	0.4
Ulcerative Colitis	0.5	0.8	2.3	-0.1	-0.9	0.4	-1.2	-0.5	-1.5	-0.7
Blood Eosinophil Count	1.4	11.0	13.0	-2.7	-3.3	3.2	-3.4	-3.6	-3.5	-3.4
Blood Platelet Count	1.9	21.5	45.0	-1.7	-3.8	6.7	-4.0	-6.0	-4.6	-4.0
Blood Red Count	3.2	30.9	56.7	1.8	4.5	-7.5	5.7	6.8	5.3	5.5
Blood White Count	0.5	3.8	6.5	-0.9	-1.6	2.2	-2.4	-2.5	-1.6	-1.8
Heel T-Score	0.2	1.7	3.1	1.8	1.2	-1.1	0.7	1.1	1.2	1.8
BMI	0.0	0.3	0.5	-0.7	-0.1	0.6	0.5	-0.6	0.7	0.1
Height	0.1	1.0	2.4	-0.8	-0.7	0.6	-1.5	-0.7	-1.1	-1.2
Waist Hip Ratio (WHR)	0.2	0.8	1.5	-0.2	0.6	-0.8	1.1	1.1	1.2	0.8
Systolic Blood Pressure	0.3	1.6	3.5	0.3	0.9	-1.9	1.1	1.5	1.3	1.3
Smoking Status	0.1	0.3	1.4	-1.2	-0.5	-0.1	-0.4	-0.2	0.1	-0.6
Allergy or Eczema	0.7	1.8	4.2	0.3	-0.5	2.0	-1.2	-0.9	-2.0	-1.3
Cardiovascular Disease	0.1	0.3	0.9	-0.3	-0.1	1.0	0.1	-0.8	-0.0	-0.0
Hypothyroidism (self reported)	0.2	0.4	1.0	-1.0	-0.6	-0.8	0.8	0.3	0.0	0.1
Respiratory disease	1.3	3.0	3.9	-2.0	-1.9	1.7	-1.1	-1.6	-1.7	-1.9
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.5	-0.8	-1.0	2.1	-0.1	-1.9	-1.0	-1.5
Lung FEV1/FVC ratio	0.1	0.7	2.0	0.5	0.6	0.2	1.4	-0.8	0.8	1.0
Lung FVC	0.0	0.2	0.4	0.2	0.3	-0.5	0.5	0.6	0.3	0.3
Neuroticism	0.4	1.0	2.4	-1.3	-1.1	0.0	-1.1	-0.0	-0.8	-1.6
Chronotype (morning person)	0.2	0.4	1.6	1.3	0.6	0.7	0.1	-0.4	-0.1	0.4
Hair Pigment	0.0	0.8	2.3	0.5	0.1	1.3	-1.5	-1.2	-0.0	-0.2
Tanning	0.2	2.3	4.6	-0.2	-1.2	1.7	-2.1	-1.9	-1.3	-1.3
Hand grip strength (left)	0.3	0.8	1.9	-0.3	-0.7	0.8	-0.9	-1.0	-1.4	-0.9
Number of treatments/medications taken	0.2	0.3	0.9	-0.5	0.4	0.1	0.7	0.1	0.9	0.5
Average weekly spirits intake	0.4	0.5	1.1	-1.0	-0.7	0.5	-0.6	-0.2	-0.8	-1.1
Sensitivity / hurt feelings	0.2	0.3	1.7	-1.3	-0.4	0.1	-0.1	0.0	0.1	-0.4
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.6	-0.7	-0.8	1.1	-0.0	-0.8	-1.3	-0.8
Hearing difficulty/problems: Yes	1.4	2.2	4.2	-0.3	1.1	-2.1	2.0	1.2	1.8	1.2
Relative age of first facial hair	0.4	0.8	1.8	-0.8	-1.0	-1.3	-1.2	-0.0	-0.2	-0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	-0.6	-0.6	0.3	0.6	-0.4	-0.7	-0.4
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.9	0.4	1.5	-0.9	1.2	1.3	2.2	1.4
Ever had hysterectomy (womb removed)	0.4	0.4	1.5	-1.2	-0.4	0.2	-0.8	0.1	0.2	-0.7
Systolic blood pressure, automated reading	0.3	0.8	2.2	-0.3	0.4	-1.2	1.5	0.9	0.5	0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.3	-1.1	-0.5	-0.3	0.4	0.4	0.6	-0.3
Angina	0.8	1.0	3.1	0.8	1.0	-0.6	1.7	0.4	0.8	1.1
Medication for hormone replacement therapy	0.1	0.1	0.3	0.3	0.4	0.2	-0.0	-0.2	0.5	0.3
Vitamin and mineral supplements	0.8	1.1	2.6	1.1	1.0	-0.3	1.6	1.3	0.5	0.9
Supplements: Zinc	2.5	2.7	4.4	-0.9	-1.3	2.1	-1.9	-2.0	-1.7	-1.3
Medication: Co-codamol	0.8	0.9	4.0	1.0	0.4	2.0	-0.5	-1.0	-0.2	0.1
Medication: Metformin	1.0	1.4	3.5	-0.7	-0.9	1.9	-0.7	-1.3	-1.1	-1.2
Diabetes (father)	0.2	0.2	0.5	-0.2	-0.5	0.7	0.1	-0.4	-0.7	-0.4
Diabetes (mother)	0.1	0.1	0.3	0.1	-0.1	0.6	0.3	-0.2	-0.2	0.0
Severe depression (siblings)	0.8	0.9	2.7	0.0	0.8	-1.2	0.8	1.7	0.8	0.3
Pack years adult smoking proportion	0.4	0.5	1.5	0.6	0.7	0.7	1.2	0.3	0.5	0.8
Impedance of leg (right)	0.1	0.4	0.7	0.6	0.7	-0.6	-0.1	0.8	0.6	0.5
Leg fat-free mass (left)	0.1	0.8	1.4	-0.8	-0.9	1.2	-0.2	-1.1	-0.8	-0.8
Trunk fat percentage	0.1	0.3	0.9	-0.2	0.3	0.9	0.6	-0.4	0.7	0.4
Hand grip strength (right)	0.3	0.9	1.6	-0.8	-1.1	0.5	-0.7	-0.9	-1.3	-1.0
Townsend deprivation index at recruitment	1.1	1.5	3.7	-0.9	-1.3	1.8	-0.1	-1.9	-0.5	-1.0
Current tobacco smoking	0.3	0.4	1.4	-0.2	-0.3	1.2	-0.5	-0.7	-0.7	-0.6
Average weekly fortified wine intake	0.4	0.5	2.3	1.5	0.9	0.2	-0.1	0.3	-0.1	0.3
Maternal smoking around birth	0.2	0.3	0.9	-0.7	-0.5	0.6	-0.9	-0.1	-0.2	-0.7
Fed-up feelings	0.9	1.7	3.4	-1.8	-1.4	0.8	-1.3	-0.8	-0.8	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.9	-1.0	-0.6	-0.3	0.4	0.4	0.2	-0.3
Relative age voice broke	1.3	2.0	3.6	-1.9	-1.8	-1.5	-1.4	-0.8	-0.8	-1.4
Taking other prescription medications	0.1	0.2	0.6	-0.2	0.2	-0.6	0.5	0.8	0.5	0.2
Age when periods started (menarche)	0.1	0.1	0.4	0.1	0.0	-0.1	-0.7	0.2	-0.3	-0.5
Bilateral oophorectomy (both ovaries removed)	3.3	3.8	5.4	1.3	2.2	-1.6	1.9	2.2	2.3	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	-0.1	-0.7	0.2	-0.6	-0.8	-1.2	-1.0
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	5.5	-1.6	-2.1	0.7	-1.1	-1.8	-2.4	-1.6
Qualifications: CSEs or equivalent	1.1	1.4	3.6	-0.9	-1.1	0.9	-1.3	-1.9	-1.0	-0.9
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.3	-0.4	-0.6	0.3	0.1	-0.5	-0.7
High blood pressure	0.3	0.8	2.0	1.4	1.3	0.9	0.4	0.1	0.6	0.8
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.1	-0.5	-1.0	1.4	-1.2	-1.0	-1.7	-1.6
Multivitamins +/- minerals	3.1	3.9	5.1	-2.2	-2.1	1.6	-2.0	-2.3	-1.5	-1.9
Stomach or abdominal pain in last month	0.7	0.9	1.9	-1.2	-0.8	-1.4	-0.9	0.9	0.0	-0.8
Supplements: Glucosamine	0.3	0.3	2.1	0.1	-0.1	1.4	-0.2	-0.2	-0.5	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.8	1.3	0.5	1.1	-0.4	0.1	-0.4	0.1
Medication: Atenolol	0.2	0.3	0.7	0.2	-0.1	0.8	-0.6	-0.8	-0.4	-0.5
Medication: Levothyroxine sodium	0.3	0.5	1.5	-0.3	-0.0	-1.2	0.4	1.2	0.3	-0.0
Sitting height	0.7	5.0	7.9	-1.5	-2.4	1.8	-2.2	-2.2	-2.8	-2.5
Chronic bronchitis/emphysema (father)	0.2	0.3	1.0	0.2	0.1	1.0	0.3	-0.6	-0.7	-0.2
High blood pressure (mother)	0.6	0.8	2.5	1.6	1.0	1.2	0.4	-0.0	0.3	0.6
Body mass index (BMI)	0.2	1.0	3.0	-0.3	0.7	-0.2	1.7	0.6	1.3	1.0
Impedance of leg (left)	0.0	0.1	0.3	-0.0	-0.0	0.3	-0.6	0.0	-0.1	-0.2
Leg predicted mass (left)	0.1	0.7	1.3	-0.8	-0.9	1.2	-0.2	-1.1	-0.8	-0.7
Trunk fat mass	0.1	0.3	1.0	-0.5	-0.0	1.0	0.6	-0.5	0.5	0.2
Waist circumference	0.4	1.4	3.4	-0.4	0.9	-0.5	1.8	1.1	1.6	1.2
Number of incorrect matches in round	1.4	2.3	3.0	1.1	1.4	-1.3	1.7	1.6	1.7	1.6
Past tobacco smoking	0.3	0.6	1.6	1.3	0.7	0.5	1.0	-0.1	-0.1	0.9
Alcohol usually taken with meals	0.3	0.5	1.8	-0.9	-0.0	-1.3	0.4	0.1	0.7	0.7
Nervous feelings	0.3	0.6	1.9	-1.4	-0.7	-0.9	0.2	0.5	-0.3	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.2	0.1	-0.8	1.1	-0.9	-1.0	-1.5	-0.9
Hearing difficulty/problems with background noise	0.8	1.3	2.6	0.5	1.3	-1.6	0.6	1.4	1.3	0.9
Hair/balding pattern: Pattern 2	0.2	0.2	0.9	-0.1	-0.2	0.9	0.0	-0.8	0.2	-0.0
Had menopause	0.4	0.6	1.9	-1.4	-0.9	0.3	-0.4	-0.7	-0.4	-0.5
Had other major operations	1.9	2.3	4.3	0.8	1.4	-1.4	2.1	1.5	1.6	1.5
Forced vital capacity (FVC)	0.5	1.8	2.8	-0.8	-1.3	1.3	-1.1	-1.7	-1.6	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.4	-0.1	-0.2	0.2	-0.1	-0.7	-0.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	-0.5	-0.5	-0.7	-0.4	0.2	-0.5	-0.9
Qualifications: None of the above	0.3	0.5	1.8	-0.3	0.7	-0.4	1.3	0.4	0.6	0.8
Financial difficulties in last 2 years	0.3	0.5	2.1	-0.3	-0.4	1.4	-0.4	-0.7	-0.1	-0.5
Mouth/teeth dental problems	0.2	0.4	1.7	0.3	-0.3	-1.3	-0.6	-0.1	-0.4	0.1
Heart attack	2.2	2.8	4.6	1.4	1.8	-1.1	2.1	0.7	2.1	1.9
Allergy	0.9	2.0	3.2	0.7	1.1	-1.8	1.4	1.2	1.8	1.6
Pain all over the body in last month	0.4	0.4	1.0	0.2	0.3	0.5	0.9	-1.0	-0.0	0.7
Diabetes (self-reported)	1.0	1.6	4.7	-0.3	-0.6	2.2	-0.5	-1.8	-1.0	-1.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	-0.3	0.5	-0.9	0.6	0.6	0.7	0.6
Medication: Ramipril	0.4	0.5	1.6	0.9	0.4	1.3	-0.6	-0.8	-0.3	0.2
Medication: Simvastatin	0.1	0.1	0.7	-0.1	0.3	0.3	-0.8	0.1	-0.2	-0.2
Fluid intelligence score	0.1	0.1	0.3	0.5	0.3	0.5	0.5	-0.1	0.1	0.3
Illnesses of siblings	0.7	1.0	3.2	0.4	-0.5	1.8	-1.2	-0.8	-0.9	-0.9
Neuroticism score	1.1	2.2	4.4	-1.9	-1.6	0.9	-1.4	-0.6	-1.3	-2.1
Weight	0.0	0.2	0.8	-0.9	-0.2	0.5	0.6	-0.1	0.2	0.0
Impedance of arm (right)	0.1	0.5	1.5	1.2	0.3	0.8	-0.9	-0.3	-0.4	-0.2
Arm fat percentage (right)	0.3	1.1	2.7	0.3	1.1	0.3	1.6	0.6	1.5	1.2
Trunk fat-free mass	0.2	1.2	3.3	-1.8	-1.3	0.7	-0.2	-0.8	-1.0	-1.1
Hip circumference	0.1	0.4	1.4	-0.1	0.4	-0.0	1.2	0.6	0.8	0.6
Time employed in main current job	0.1	0.1	0.2	0.1	0.4	-0.4	0.3	-0.2	0.3	0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.5	-0.5	-0.4	0.7	-0.1	-0.4	0.1	-0.7
Father’s age at death	0.4	0.5	0.8	0.8	0.9	-0.0	0.8	0.3	0.7	0.9
Worrier / anxious feelings	0.3	0.5	1.7	0.1	-0.4	0.5	-1.3	-0.0	-0.6	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.9	-1.5	-1.7	0.4	-0.8	-0.9	-1.3	-1.5
Falls in the last year	1.7	2.3	7.2	-0.0	1.1	-1.8	2.7	0.9	1.4	1.3
Hair/balding pattern: Pattern 3	1.9	2.9	3.6	-1.4	-1.7	1.8	-1.7	-1.7	-1.6	-1.9
Number of live births	0.1	0.2	0.5	0.3	0.1	0.7	-0.5	-0.3	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.6	-0.4	-0.7	0.8	0.1	-1.3	-1.0	-0.6
Pulse rate	2.1	3.6	5.4	1.2	1.8	-1.6	1.7	2.1	2.3	2.2
Happiness	0.6	0.8	2.3	0.0	-0.9	0.7	-0.3	-0.5	-1.5	-1.2
Noisy workplace	0.3	0.4	0.9	0.1	0.3	-1.0	0.7	0.8	0.5	0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.9	-1.7	-1.4	-0.8	0.1	-1.0	-0.8	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.4	-0.3	0.1	-0.4	-0.3	0.1	-0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	1.6	-0.3	0.2	0.7	1.3	0.4	0.3	0.1
Asthma	1.2	2.4	4.0	-2.0	-1.9	0.7	-1.3	-1.3	-1.6	-1.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.6	-0.9	-0.1	-1.3	0.2	0.6	-0.3	-0.4
Medication: Cholesterol lowering	0.2	0.4	1.1	1.1	0.6	0.6	-0.8	-0.0	-0.2	-0.2
Depression (self-reported)	0.8	0.9	2.6	-0.8	-0.6	1.6	-0.5	-1.3	-0.5	-0.8
Medication: Lansoprazole	0.1	0.1	0.4	0.2	-0.2	0.3	-0.6	-0.1	-0.3	-0.3
Prospective memory result	1.2	1.5	2.9	-0.1	0.6	-1.7	1.3	1.1	1.5	1.5
Lung cancer (father)	0.9	1.0	2.1	-0.4	0.6	-1.4	1.0	1.2	1.5	0.6
Illnesses of mother	3.6	4.4	6.6	-2.5	-2.6	1.1	-1.9	-2.3	-1.7	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	1.9	-1.2	-1.4	0.6	0.0	-1.1	-1.4	-1.1
Pulse wave Arterial Stiffness index	0.9	1.0	2.4	1.6	1.1	-0.9	0.3	0.6	0.5	1.4
Impedance of arm (left)	0.1	0.4	1.0	1.0	0.0	0.7	-0.9	-0.6	-0.5	-0.2
Arm fat mass (right)	0.1	0.4	1.4	-0.4	0.3	0.6	1.2	0.0	0.8	0.5
Trunk predicted mass	0.2	1.2	3.2	-1.8	-1.3	0.6	-0.3	-0.8	-1.0	-1.1
Standing height	0.3	3.0	4.8	-1.2	-1.8	1.3	-2.0	-1.6	-2.2	-1.9
Length of working week for main job	0.2	0.2	0.6	-0.2	-0.6	0.4	-0.2	-0.8	-0.1	-0.3
Exposure to tobacco smoke at home	1.2	1.3	3.3	1.2	1.1	-0.3	0.7	0.5	1.8	1.5
Breastfed as a baby	0.6	0.7	1.9	0.6	0.7	-1.4	0.5	0.9	0.5	0.8
Tense / ‘highly strung’	0.6	1.0	2.6	-0.5	0.4	-1.3	1.2	1.6	0.9	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	3.7	-0.7	-1.1	1.9	-1.5	-1.5	-1.4	-1.9
Hair/balding pattern: Pattern 4	1.1	2.8	4.2	1.4	1.9	-2.0	0.5	1.8	1.9	1.6
Birth weight of first child	1.1	1.9	3.5	1.9	1.5	-1.3	1.4	1.3	0.9	1.4
Peak expiratory flow (PEF)	0.2	0.5	0.8	-0.3	-0.7	0.5	-0.8	-0.7	-0.7	-0.9
Pulse wave reflection index	2.6	3.2	5.9	-1.0	-1.9	0.5	-2.1	-2.1	-2.4	-1.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.4	0.5	-0.3	0.2	-1.2	0.0	-0.7	-0.7
Loud music exposure frequency	4.9	5.3	7.7	1.7	1.8	-2.3	2.8	2.7	2.1	2.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.4	-0.8	-0.2	-1.2	0.9	-0.3	0.6	0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	0.2	0.5	0.0	0.7	0.6	0.7	0.3
Blood clot in the leg (DVT)	0.3	0.4	1.5	1.2	0.6	0.6	-0.5	-0.0	-0.2	-0.1
Medication: Paracetamol	0.3	0.5	1.2	-0.3	-0.8	0.4	-1.1	-0.2	-0.7	-1.1
Headache pain in last month	0.3	0.5	1.3	-1.1	-0.9	-0.4	0.1	-0.0	-0.3	-0.9
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	3.0	-1.7	-1.4	-0.6	-0.2	0.1	-1.0	-1.1
Glaucoma (self-reported)	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.3	0.1	0.2	0.0
Gout (self-reported)	0.8	1.1	4.7	0.7	0.3	2.2	0.2	-1.3	0.0	0.6
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.8	-0.8	0.2	-2.0	1.5	1.4	0.8	0.7
Medication: Amlodipine	0.9	1.2	2.8	1.7	1.5	0.3	1.1	0.1	0.9	1.3
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.9	0.6	-0.3	0.6	-1.4	-0.4	-0.9	-0.9
Birth weight	2.7	5.8	10.6	3.2	3.0	-1.0	2.5	2.3	1.7	2.4
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	-0.5	-0.9	0.8	-0.5	-0.4	-1.1	-1.2
High blood pressure (siblings)	0.2	0.3	0.8	-0.5	-0.4	0.3	-0.1	-0.9	-0.8	-0.6
Forced vital capacity (FVC), Best measure	0.5	1.9	3.0	-1.4	-1.7	0.8	-0.7	-1.3	-1.7	-1.6
Body fat percentage	0.2	0.6	1.7	0.0	0.8	0.4	1.0	0.4	1.3	0.9
Leg fat percentage (right)	0.8	3.0	6.4	0.3	1.6	-1.0	2.0	1.7	2.5	1.9
Arm fat-free mass (right)	0.2	1.3	3.6	-1.9	-1.4	0.8	-0.3	-0.8	-0.9	-1.0
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.4	0.2	0.1	-0.1	0.1	0.5	0.2
Comparative body size at age 10	1.4	3.9	9.6	-1.0	-1.6	3.1	-1.1	-2.0	-2.2	-1.9
Number of full brothers	0.5	0.6	2.6	-0.3	-0.4	-0.4	-1.6	-0.4	-0.4	-0.9
Worry too long after embarrassment	0.3	0.5	1.4	-1.2	-0.7	-0.3	-0.8	-0.1	-0.4	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.0	0.4	0.5	0.4	-0.4	0.5	0.2
Wheeze or whistling in the chest in last year	0.7	1.2	4.6	-2.1	-1.4	-0.2	-0.1	-0.3	-0.6	-1.3
Number of children fathered	2.2	2.5	4.7	0.5	1.7	-2.2	0.8	1.9	1.6	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.5	0.7	0.1	-0.0	-0.4	-0.0	-0.3	0.1
Age at first live birth	0.3	0.6	1.9	1.4	0.9	-0.3	0.5	0.8	-0.3	0.4
Pulse wave peak to peak time	0.6	0.7	1.5	-1.2	-0.8	0.9	-0.2	-0.4	-0.3	-1.2
Health satisfaction	0.3	0.4	1.1	1.1	0.2	-0.8	-0.2	0.7	-0.4	-0.2
Shortness of breath walking on level ground	0.1	0.1	0.4	0.1	-0.0	0.3	-0.4	-0.6	-0.4	-0.5
Qualifications: College or University degree	0.3	0.8	1.7	-1.1	-1.3	0.3	-0.2	-0.9	-1.1	-1.0
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.3	-0.2	0.5	-0.0	-0.7	-0.6	-0.1
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.3	-1.1	-1.5	1.5	-1.1	-1.0	-1.6	-1.8
Emphysema/chronic bronchitis	0.7	0.8	1.2	-0.3	-0.8	0.9	-1.0	-0.8	-1.0	-1.1
Medication for pain relief, constipation, heartburn	0.5	0.8	2.6	0.4	-0.5	1.6	-1.1	-0.8	-0.9	-0.5
Neck or shoulder pain in last month	0.3	0.4	1.3	0.2	0.3	-1.1	-0.1	1.0	0.3	-0.1
Medication: Blood pressure	0.7	1.2	2.5	1.6	1.3	0.8	0.9	-0.4	1.0	1.2
Angina (self-reported)	0.6	0.8	2.6	0.8	0.9	-0.3	1.6	0.2	0.6	1.0
Migraine (self-reported)	1.4	1.7	2.4	1.3	1.1	-1.3	1.5	1.4	1.1	1.3
Medication: Ibuprofen	0.2	0.3	1.2	-0.5	0.3	-1.1	0.4	0.6	0.0	0.0
Medication: Allopurinol	0.4	0.6	2.7	0.1	-0.1	1.6	0.3	-1.1	0.3	0.2
Medication: Omeprazole	0.2	0.3	0.6	0.2	0.4	0.2	0.8	-0.8	0.0	0.6
Medication: Seretide 50 evohaler	0.6	0.7	1.6	-0.6	-0.6	1.3	-0.9	-1.0	-0.3	-1.0
Mean time to correctly identify matches	0.1	0.2	0.6	-0.0	0.7	-0.2	-0.1	-0.3	0.8	0.3
Heart disease (mother)	0.2	0.2	0.5	0.4	0.6	0.0	0.7	0.1	0.3	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.6	0.8	0.2	0.3	-0.1	-0.0	0.1	0.3
Whole body fat mass	0.1	0.3	0.6	-0.5	0.2	0.8	0.7	-0.2	0.7	0.4
Leg fat mass (right)	0.3	1.3	2.9	0.2	1.1	0.0	1.7	0.9	1.7	1.3
Arm predicted mass (right)	0.4	1.9	4.6	-2.1	-1.7	1.1	-0.6	-1.2	-1.2	-1.3
Pulse rate, automated reading	0.9	3.0	4.6	1.0	1.8	-1.2	1.8	1.8	2.1	2.1
Alcohol intake frequency.	0.1	0.1	0.4	-0.3	-0.2	-0.2	-0.0	0.5	-0.1	-0.7
Comparative height size at age 10	0.1	0.7	1.9	-0.3	-0.5	1.4	-1.1	-1.1	-0.4	-0.4
Number of full sisters	0.6	0.8	1.8	0.5	1.1	-0.2	1.3	0.7	0.8	0.9
Suffer from ‘nerves’	0.2	0.3	0.9	0.1	-0.0	0.6	-1.0	0.1	-0.6	-0.8
Overall health rating	0.4	0.9	1.5	-1.0	-0.8	1.1	-0.3	-1.0	-0.9	-1.2
Chest pain or discomfort	0.7	1.0	1.9	-0.2	-0.8	1.4	-1.2	-0.7	-0.8	-1.2
Had major operations	0.5	0.6	1.0	1.0	0.9	-0.5	0.8	0.7	0.5	0.8
Age at last live birth	0.1	0.2	0.4	0.2	-0.0	-0.5	-0.3	0.6	-0.5	-0.4
Family relationship satisfaction	0.8	0.9	3.4	1.8	1.1	-0.3	0.5	1.0	0.4	0.7
Leg pain on walking	0.5	0.6	1.8	-0.5	-0.1	-1.0	-0.6	1.3	-0.4	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.2	1.5	1.1	-0.6	-0.2	0.8	0.8	1.0
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.3	-1.5	-1.3	0.7	-0.4	-0.9	-0.9	-1.1
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.5	0.0	0.9	-2.1	1.1	2.0	1.1	1.0
Medication: Aspirin	0.1	0.1	0.3	0.1	0.5	-0.2	0.2	0.0	0.6	0.3
Supplements: Vitamin C	0.5	0.5	1.5	0.4	0.4	-1.1	-1.2	0.1	0.8	0.3
Knee pain experienced in last month	0.1	0.2	0.7	-0.1	-0.1	-0.8	-0.1	0.8	0.2	-0.0
Hypertension (Self-reported)	0.3	0.7	1.7	1.1	1.0	1.3	0.7	-0.4	0.5	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	-0.4	-0.5	0.7	-0.3	-0.6	-0.4	-0.7
Illnesses of father: Heart disease	2.5	3.5	6.5	-1.5	-2.0	2.3	-1.2	-2.6	-1.7	-1.3
Illnesses of siblings: Diabetes	0.4	0.6	1.4	0.2	0.7	-0.8	1.2	0.3	0.5	0.9
Smoking status: Previous	0.4	0.5	1.4	-1.2	-0.2	-1.1	-0.3	0.6	0.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	-0.7	-0.8	0.3	0.0	-0.3	-0.6	-0.9
Whole body fat-free mass	0.2	1.0	2.1	-1.4	-1.2	1.0	-0.1	-0.9	-0.9	-0.9
Leg fat-free mass (right)	0.3	1.4	2.4	-1.0	-1.3	1.5	-0.5	-1.4	-1.2	-1.1
Arm fat percentage (left)	0.2	0.8	1.9	0.3	0.9	0.3	1.4	0.4	1.3	1.0
Average weekly red wine intake	0.3	0.4	1.2	-0.2	0.0	-1.0	0.6	1.1	-0.0	-0.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.6	0.7	-0.1	-0.0	0.2	0.6	0.6
Mood swings	1.5	2.7	6.4	-2.5	-1.7	1.9	-0.4	-1.2	-0.6	-1.9
Loneliness, isolation	1.5	2.0	4.1	-1.9	-1.5	0.6	-1.3	-0.7	-1.4	-2.0
Long-standing illness, disability or infirmity	0.1	0.2	0.8	-0.9	-0.3	-0.0	0.5	0.0	-0.1	-0.2
Ever had bowel cancer screening	0.7	0.8	1.7	1.3	1.2	0.2	0.1	0.6	1.0	1.0
Diabetes diagnosed by doctor	0.4	0.7	3.1	0.3	-0.1	1.8	0.2	-1.2	-0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.6	1.0	0.3	1.3	-1.0	-0.6	-0.6	-0.6
Friendships satisfaction	0.4	0.5	1.7	1.3	0.6	-0.1	-0.5	1.1	0.1	-0.3
Qualifications: nursing, teaching	1.1	1.7	2.7	1.6	1.6	-0.3	1.1	1.3	1.5	1.3
Commuting to job workplace: Walk	0.1	0.1	0.2	0.1	0.2	0.5	0.5	-0.1	0.1	0.3
Eye problems/disorders: Cataract	0.6	0.7	1.5	-1.0	-0.5	1.2	-0.0	-1.0	-0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	-0.8	-0.4	1.0	0.1	-0.4	-0.4	-0.5
Medication for cholesterol	0.4	0.6	1.5	1.1	0.8	-0.4	0.2	1.2	0.5	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.7	-0.5	-0.1	0.6	-0.3	-0.2	0.2
Back pain experienced in last month	1.5	2.2	5.1	-2.2	-2.0	0.3	-1.0	-0.3	-1.6	-1.7
Mineral and other dietary supplements	0.3	0.4	1.5	0.4	0.2	-1.2	0.3	0.9	0.1	-0.1
Breast cancer (self-reported)	0.2	0.3	1.1	0.4	0.0	-1.0	0.1	0.8	-0.2	-0.2
Asthma (self-reported)	1.2	2.5	4.3	-2.1	-2.0	0.8	-1.1	-1.2	-1.5	-1.8
Osteoporosis (self-reported)	1.2	1.5	2.4	-1.5	-1.4	1.0	-0.9	-1.0	-1.2	-1.3
Osteoarthritis (self-reported)	0.3	0.4	2.1	0.6	0.3	1.4	-0.5	-0.5	0.2	0.2
Medication: Aspirin	0.1	0.2	0.4	0.3	0.6	-0.3	0.3	0.2	0.6	0.4
Medication: Gliclazide	0.3	0.3	1.1	0.1	-0.2	1.1	-0.4	-0.6	-0.3	-0.6
Illnesses of father: None of the above (group 1)	1.4	1.7	2.8	0.9	1.3	-1.6	0.2	1.7	1.6	1.2
Smoking status: Current	0.5	0.7	1.7	-0.3	-0.5	1.3	-0.8	-0.9	-1.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	0.5	-0.0	-0.2	-0.2	-0.6	-0.3	0.3
Whole body water mass	0.1	0.8	2.0	-1.4	-1.1	0.8	-0.1	-0.8	-0.8	-0.8
Leg predicted mass (right)	0.3	1.5	2.5	-1.0	-1.3	1.6	-0.6	-1.4	-1.2	-1.2
Arm fat mass (left)	0.1	0.4	1.1	-0.5	0.2	0.5	1.0	-0.1	0.8	0.5
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	-0.8	-0.1	0.8	0.7	-0.3	0.3	0.0
Average weekly champagne plus white wine intake	0.4	0.5	1.3	-1.0	-0.6	-0.4	-1.1	-0.2	-0.4	-0.9
Miserableness	0.7	1.2	2.1	-0.7	-1.0	1.4	-1.3	-1.0	-1.0	-1.1
Guilty feelings	3.3	4.9	9.7	-1.8	-2.2	1.4	-2.5	-1.5	-2.5	-3.1
Wears glasses or contact lenses	1.0	1.2	2.0	1.0	1.3	-0.6	0.7	1.1	1.4	1.4
Ever taken oral contraceptive pill	0.8	0.9	2.9	-0.3	-0.5	1.7	-0.4	-1.1	-0.5	-1.0
Hearing aid user	0.4	0.5	1.7	0.2	0.2	-0.8	-0.6	1.3	-0.4	-0.5
Mother’s age at death	0.8	1.0	2.4	1.6	1.2	-0.6	0.5	1.1	0.4	0.8
Financial situation satisfaction	2.4	3.0	4.4	0.0	-1.2	2.0	-2.0	-1.8	-2.1	-1.9
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.5	-0.3	-0.2	-0.7	-0.3	0.2	0.0	-0.3
Commuting to job workplace: Public transport	0.1	0.2	0.2	0.4	0.4	-0.4	-0.2	0.4	0.4	0.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	0.0	0.4	-0.5	0.5	0.6	0.5	0.5
Medication: Blood pressure	0.3	0.6	1.1	-0.3	-0.7	0.6	-1.0	-0.9	-0.8	-0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.4	-0.1	-0.6	0.3	0.6	0.7	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.6	-0.3	0.1	-0.3	-0.3	0.1	0.8	0.4
High cholesterol (Self-reported)	0.4	0.7	2.9	-1.7	-0.8	0.4	-0.4	-0.9	-0.3	-0.6
Medication: Bendroflumethiazide	3.2	4.8	9.5	0.2	-1.6	2.4	-3.1	-1.7	-2.8	-2.3
Medication: Paracetamol	0.1	0.2	0.5	0.2	-0.3	-0.0	-0.7	0.4	-0.3	-0.7
Medication: Lisinopril	0.2	0.3	0.9	-0.9	-0.4	0.1	0.1	0.2	-0.6	-1.0
Medication: Atorvastatin	0.8	1.0	1.7	-1.3	-0.9	1.0	-0.3	-1.2	-0.8	-1.2
Illnesses of father: High blood pressure	0.0	0.0	0.1	0.1	-0.1	-0.3	0.0	-0.1	-0.2	-0.2
Alcohol drinker status: Never	0.3	0.4	1.8	-0.2	-0.2	-1.3	0.4	0.8	0.0	0.1
Ever smoked	0.4	0.6	1.2	-1.1	-0.7	0.5	-1.1	-0.7	-0.3	-1.0
Basal metabolic rate	0.1	0.8	1.8	-1.3	-1.0	0.9	-0.1	-0.8	-0.8	-0.8
Leg fat percentage (left)	0.5	1.8	4.2	-0.1	1.2	-0.5	1.6	1.2	2.1	1.5
Arm fat-free mass (left)	0.2	0.9	3.4	-1.8	-1.1	0.5	-0.1	-0.4	-0.7	-0.9
Number of operations (self-reported)	0.6	0.9	1.4	0.5	1.0	-0.8	0.8	1.2	1.1	0.9
Average weekly beer plus cider intake	0.5	0.7	1.8	0.4	-0.4	0.8	-1.3	-0.6	-1.0	-0.9
Irritability	0.7	1.2	2.7	-1.2	-1.0	0.7	-1.2	-0.2	-1.0	-1.7
Risk taking	0.3	0.4	1.0	-0.3	0.3	-0.2	0.8	0.6	1.0	0.8
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	0.6	0.2	0.9	-0.9	-0.2	-0.2	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	2.1	-0.4	0.2	0.2	1.4	-0.1	0.1	0.5
Age started oral contraceptive pill	0.3	0.4	1.2	-1.1	-0.3	-0.3	0.7	0.7	-0.2	-0.3
Diastolic blood pressure, automated reading	0.5	1.5	3.8	0.1	1.0	-1.3	1.9	1.1	1.0	1.4
Ever depressed for a whole week	0.4	0.5	1.1	0.1	-0.5	0.1	-0.9	-0.2	-1.0	-1.0
Unable to work because of sickness or disability	2.4	3.1	6.5	-0.4	0.9	-2.1	2.5	2.0	1.9	1.6
Commuting to job workplace: Cycle	0.4	0.5	1.7	1.3	0.9	0.0	0.5	0.7	-0.2	0.4
Myopia	0.7	1.0	3.5	1.9	0.9	1.4	-0.4	-0.3	0.3	0.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.0	-1.7	-1.6	-0.4	-1.0	-0.3	-0.9	-1.2
Cholesterol lowering medication	0.8	1.1	5.5	-2.3	-0.6	-1.3	0.5	-0.1	0.3	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.1	-0.3	0.0	0.7	0.3	-1.0	-0.1	0.1
Pain experienced in last month	0.2	0.4	1.6	0.4	0.2	1.2	-0.3	-0.9	-0.3	-0.1
Supplements: Calcium	2.3	2.5	3.8	-1.9	-1.7	1.3	-1.7	-1.4	-1.4	-1.6
Basal cell carcinoma (self-reported)	0.7	0.8	1.7	-1.0	-0.9	1.0	-0.4	-1.3	-0.7	-0.6
Heart attack/myocardial infarction (self-reported)	2.5	3.3	5.2	1.6	2.0	-1.1	2.2	0.9	2.3	2.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.7	1.6	1.0	0.5	-0.4	0.2	0.0	0.3
Heart disease (siblings)	2.4	3.0	4.5	1.2	2.0	-1.5	1.8	1.3	2.1	2.0
Alcohol drinker status: Previous	0.4	0.5	1.4	0.3	-0.4	1.2	0.1	-0.7	-0.8	-0.7
Pack years of smoking	0.2	0.3	0.8	0.4	0.5	0.7	0.9	0.1	0.2	0.5
Impedance of whole body	0.0	0.2	0.6	0.7	0.1	0.4	-0.8	-0.2	-0.2	-0.1
Leg fat mass (left)	0.2	0.9	2.3	0.0	0.8	0.4	1.5	0.5	1.4	1.1
Arm predicted mass (left)	0.1	0.5	2.3	-1.5	-0.8	0.2	0.1	-0.1	-0.4	-0.7