TWAS hub - KLRC4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0464	0.0149	1.3e-05	0.040	0.017	0.033	0.036	0.036	7.7e-13	2.3e-06	6.9e-11	7.3e-12	7.3e-12
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0373	0.0252	3.4e-03	0.013	0.013	0.012	NA	0.015	1.2e-02	1.0e-02	1.5e-02	NA	7.0e-03
3	TCGA	Brain Lower Grade Glioma	0.0454	0.0231	1.3e-04	0.043	0.037	0.035	NA	0.039	1.2e-05	4.5e-05	6.4e-05	NA	2.9e-05
4	TCGA	Lung Adenocarcinoma	0.0887	0.0548	1.1e-04	0.046	0.030	0.017	NA	0.037	3.8e-06	1.9e-04	4.0e-03	NA	3.2e-05
5	TCGA	Lung Squamous Cell Carcinoma	0.0638	0.0537	6.7e-03	0.010	0.015	0.013	NA	0.010	2.6e-02	6.1e-03	1.2e-02	NA	2.4e-02
6	TCGA	Stomach Adenocarcinoma	0.0630	0.0400	3.5e-04	0.046	0.059	0.058	NA	0.058	2.9e-04	4.4e-05	5.0e-05	NA	5.3e-05
7	TCGA	Thyroid Carcinoma	0.0710	0.0420	4.1e-05	0.021	0.049	0.041	NA	0.039	3.3e-03	1.6e-05	6.5e-05	NA	1.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Loud music exposure frequency	4.9	5.3	7.7	1.7	1.8	-2.3	2.8	2.7	2.1	2.4
Illnesses of mother	3.6	4.4	6.6	-2.5	-2.6	1.1	-1.9	-2.3	-1.7	-2.2
Bilateral oophorectomy (both ovaries removed)	3.3	3.8	5.4	1.3	2.2	-1.6	1.9	2.2	2.3	2.0
Guilty feelings	3.3	4.9	9.7	-1.8	-2.2	1.4	-2.5	-1.5	-2.5	-3.1
Blood Red Count	3.2	30.9	56.7	1.8	4.5	-7.5	5.7	6.8	5.3	5.5
Medication: Bendroflumethiazide	3.2	4.8	9.5	0.2	-1.6	2.4	-3.1	-1.7	-2.8	-2.3
Multivitamins +/- minerals	3.1	3.9	5.1	-2.2	-2.1	1.6	-2.0	-2.3	-1.5	-1.9
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	5.5	-1.6	-2.1	0.7	-1.1	-1.8	-2.4	-1.6
Birth weight	2.7	5.8	10.6	3.2	3.0	-1.0	2.5	2.3	1.7	2.4
Pulse wave reflection index	2.6	3.2	5.9	-1.0	-1.9	0.5	-2.1	-2.1	-2.4	-1.7
Supplements: Zinc	2.5	2.7	4.4	-0.9	-1.3	2.1	-1.9	-2.0	-1.7	-1.3
Illnesses of father: Heart disease	2.5	3.5	6.5	-1.5	-2.0	2.3	-1.2	-2.6	-1.7	-1.3
Heart attack/myocardial infarction (self-reported)	2.5	3.3	5.2	1.6	2.0	-1.1	2.2	0.9	2.3	2.0
Alzheimer’s Disease (including proxy)	2.4	3.5	5.2	0.9	1.6	-2.0	2.0	2.3	1.9	2.1
Financial situation satisfaction	2.4	3.0	4.4	0.0	-1.2	2.0	-2.0	-1.8	-2.1	-1.9
Unable to work because of sickness or disability	2.4	3.1	6.5	-0.4	0.9	-2.1	2.5	2.0	1.9	1.6
Heart disease (siblings)	2.4	3.0	4.5	1.2	2.0	-1.5	1.8	1.3	2.1	2.0
Supplements: Calcium	2.3	2.5	3.8	-1.9	-1.7	1.3	-1.7	-1.4	-1.4	-1.6
Heart attack	2.2	2.8	4.6	1.4	1.8	-1.1	2.1	0.7	2.1	1.9
Number of children fathered	2.2	2.5	4.7	0.5	1.7	-2.2	0.8	1.9	1.6	1.4
Pulse rate	2.1	3.6	5.4	1.2	1.8	-1.6	1.7	2.1	2.3	2.2
Bipolar Disorder (2011)	1.9	1.9	4.0	-0.1	0.9	-1.6	2.0	1.0	1.6	1.6
Blood Platelet Count	1.9	21.5	45.0	-1.7	-3.8	6.7	-4.0	-6.0	-4.6	-4.0
Had other major operations	1.9	2.3	4.3	0.8	1.4	-1.4	2.1	1.5	1.6	1.5
Hair/balding pattern: Pattern 3	1.9	2.9	3.6	-1.4	-1.7	1.8	-1.7	-1.7	-1.6	-1.9
Depressed Affect (Nagel 2018)	1.7	3.7	6.1	-2.5	-2.1	1.7	-1.6	-1.6	-1.4	-2.3
Falls in the last year	1.7	2.3	7.2	-0.0	1.1	-1.8	2.7	0.9	1.4	1.3
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.3	-1.1	-1.5	1.5	-1.1	-1.0	-1.6	-1.8
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.9	0.4	1.5	-0.9	1.2	1.3	2.2	1.4
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.5	0.0	0.9	-2.1	1.1	2.0	1.1	1.0
Mood swings	1.5	2.7	6.4	-2.5	-1.7	1.9	-0.4	-1.2	-0.6	-1.9
Loneliness, isolation	1.5	2.0	4.1	-1.9	-1.5	0.6	-1.3	-0.7	-1.4	-2.0
Back pain experienced in last month	1.5	2.2	5.1	-2.2	-2.0	0.3	-1.0	-0.3	-1.6	-1.7
Blood Eosinophil Count	1.4	11.0	13.0	-2.7	-3.3	3.2	-3.4	-3.6	-3.5	-3.4
Hearing difficulty/problems: Yes	1.4	2.2	4.2	-0.3	1.1	-2.1	2.0	1.2	1.8	1.2
Number of incorrect matches in round	1.4	2.3	3.0	1.1	1.4	-1.3	1.7	1.6	1.7	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	3.7	-0.7	-1.1	1.9	-1.5	-1.5	-1.4	-1.9
Comparative body size at age 10	1.4	3.9	9.6	-1.0	-1.6	3.1	-1.1	-2.0	-2.2	-1.9
Migraine (self-reported)	1.4	1.7	2.4	1.3	1.1	-1.3	1.5	1.4	1.1	1.3
Illnesses of father: None of the above (group 1)	1.4	1.7	2.8	0.9	1.3	-1.6	0.2	1.7	1.6	1.2
Respiratory disease	1.3	3.0	3.9	-2.0	-1.9	1.7	-1.1	-1.6	-1.7	-1.9
Relative age voice broke	1.3	2.0	3.6	-1.9	-1.8	-1.5	-1.4	-0.8	-0.8	-1.4
Primary Biliary Cirrhosis	1.2	1.8	2.8	-1.3	-1.7	0.8	-1.3	-1.3	-1.2	-1.5
Asthma	1.2	2.4	4.0	-2.0	-1.9	0.7	-1.3	-1.3	-1.6	-1.8
Prospective memory result	1.2	1.5	2.9	-0.1	0.6	-1.7	1.3	1.1	1.5	1.5
Exposure to tobacco smoke at home	1.2	1.3	3.3	1.2	1.1	-0.3	0.7	0.5	1.8	1.5
Asthma (self-reported)	1.2	2.5	4.3	-2.1	-2.0	0.8	-1.1	-1.2	-1.5	-1.8
Osteoporosis (self-reported)	1.2	1.5	2.4	-1.5	-1.4	1.0	-0.9	-1.0	-1.2	-1.3
Townsend deprivation index at recruitment	1.1	1.5	3.7	-0.9	-1.3	1.8	-0.1	-1.9	-0.5	-1.0
Qualifications: CSEs or equivalent	1.1	1.4	3.6	-0.9	-1.1	0.9	-1.3	-1.9	-1.0	-0.9
Neuroticism score	1.1	2.2	4.4	-1.9	-1.6	0.9	-1.4	-0.6	-1.3	-2.1
Hair/balding pattern: Pattern 4	1.1	2.8	4.2	1.4	1.9	-2.0	0.5	1.8	1.9	1.6
Birth weight of first child	1.1	1.9	3.5	1.9	1.5	-1.3	1.4	1.3	0.9	1.4
Qualifications: nursing, teaching	1.1	1.7	2.7	1.6	1.6	-0.3	1.1	1.3	1.5	1.3
Schizophrenia (2018)	1.0	2.1	5.0	-0.6	-1.4	1.1	-2.2	-1.3	-1.6	-1.6
LDL Cholesterol	1.0	1.5	3.2	-1.8	-1.6	0.6	-0.2	-1.6	-1.0	-0.9
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.5	-0.8	-1.0	2.1	-0.1	-1.9	-1.0	-1.5
Medication: Metformin	1.0	1.4	3.5	-0.7	-0.9	1.9	-0.7	-1.3	-1.1	-1.2
Diabetes (self-reported)	1.0	1.6	4.7	-0.3	-0.6	2.2	-0.5	-1.8	-1.0	-1.1
Wears glasses or contact lenses	1.0	1.2	2.0	1.0	1.3	-0.6	0.7	1.1	1.4	1.4
Neuroticism (Nagel 2018)	0.9	2.2	3.7	-1.9	-1.6	1.0	-1.4	-1.2	-1.2	-1.9
Fed-up feelings	0.9	1.7	3.4	-1.8	-1.4	0.8	-1.3	-0.8	-0.8	-1.7
Allergy	0.9	2.0	3.2	0.7	1.1	-1.8	1.4	1.2	1.8	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.9	-1.5	-1.7	0.4	-0.8	-0.9	-1.3	-1.5
Lung cancer (father)	0.9	1.0	2.1	-0.4	0.6	-1.4	1.0	1.2	1.5	0.6
Pulse wave Arterial Stiffness index	0.9	1.0	2.4	1.6	1.1	-0.9	0.3	0.6	0.5	1.4
Medication: Amlodipine	0.9	1.2	2.8	1.7	1.5	0.3	1.1	0.1	0.9	1.3
Pulse rate, automated reading	0.9	3.0	4.6	1.0	1.8	-1.2	1.8	1.8	2.1	2.1
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.3	-1.5	-1.3	0.7	-0.4	-0.9	-0.9	-1.1
Alzheimer’s Disease (in mother)	0.8	1.0	1.7	0.8	0.9	-0.8	1.1	1.3	0.8	1.0
Neuroticism (2016)	0.8	1.1	1.8	-1.1	-0.8	1.2	-0.9	-1.3	-0.8	-1.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.8	0.6	0.8	-1.1	0.8	1.7	0.6	0.4
Angina	0.8	1.0	3.1	0.8	1.0	-0.6	1.7	0.4	0.8	1.1
Vitamin and mineral supplements	0.8	1.1	2.6	1.1	1.0	-0.3	1.6	1.3	0.5	0.9
Medication: Co-codamol	0.8	0.9	4.0	1.0	0.4	2.0	-0.5	-1.0	-0.2	0.1
Severe depression (siblings)	0.8	0.9	2.7	0.0	0.8	-1.2	0.8	1.7	0.8	0.3
Hearing difficulty/problems with background noise	0.8	1.3	2.6	0.5	1.3	-1.6	0.6	1.4	1.3	0.9
Depression (self-reported)	0.8	0.9	2.6	-0.8	-0.6	1.6	-0.5	-1.3	-0.5	-0.8
Gout (self-reported)	0.8	1.1	4.7	0.7	0.3	2.2	0.2	-1.3	0.0	0.6
Leg fat percentage (right)	0.8	3.0	6.4	0.3	1.6	-1.0	2.0	1.7	2.5	1.9
Family relationship satisfaction	0.8	0.9	3.4	1.8	1.1	-0.3	0.5	1.0	0.4	0.7
Ever taken oral contraceptive pill	0.8	0.9	2.9	-0.3	-0.5	1.7	-0.4	-1.1	-0.5	-1.0
Mother’s age at death	0.8	1.0	2.4	1.6	1.2	-0.6	0.5	1.1	0.4	0.8
Medication: Atorvastatin	0.8	1.0	1.7	-1.3	-0.9	1.0	-0.3	-1.2	-0.8	-1.2
Cholesterol lowering medication	0.8	1.1	5.5	-2.3	-0.6	-1.3	0.5	-0.1	0.3	-0.1
Depression (Nagel 2018)	0.7	1.1	3.8	-1.9	-1.4	0.5	-0.2	-0.7	-0.7	-0.8
Alzheimer’s Disease (in father)	0.7	0.8	1.5	0.2	0.6	-0.8	1.2	0.9	0.9	1.1
Allergy or Eczema	0.7	1.8	4.2	0.3	-0.5	2.0	-1.2	-0.9	-2.0	-1.3
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.1	-0.5	-1.0	1.4	-1.2	-1.0	-1.7	-1.6
Stomach or abdominal pain in last month	0.7	0.9	1.9	-1.2	-0.8	-1.4	-0.9	0.9	0.0	-0.8
Sitting height	0.7	5.0	7.9	-1.5	-2.4	1.8	-2.2	-2.2	-2.8	-2.5
Illnesses of siblings	0.7	1.0	3.2	0.4	-0.5	1.8	-1.2	-0.8	-0.9	-0.9
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.8	-0.8	0.2	-2.0	1.5	1.4	0.8	0.7
Wheeze or whistling in the chest in last year	0.7	1.2	4.6	-2.1	-1.4	-0.2	-0.1	-0.3	-0.6	-1.3
Emphysema/chronic bronchitis	0.7	0.8	1.2	-0.3	-0.8	0.9	-1.0	-0.8	-1.0	-1.1
Medication: Blood pressure	0.7	1.2	2.5	1.6	1.3	0.8	0.9	-0.4	1.0	1.2
Chest pain or discomfort	0.7	1.0	1.9	-0.2	-0.8	1.4	-1.2	-0.7	-0.8	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.2	1.5	1.1	-0.6	-0.2	0.8	0.8	1.0
Ever had bowel cancer screening	0.7	0.8	1.7	1.3	1.2	0.2	0.1	0.6	1.0	1.0
Miserableness	0.7	1.2	2.1	-0.7	-1.0	1.4	-1.3	-1.0	-1.0	-1.1
Irritability	0.7	1.2	2.7	-1.2	-1.0	0.7	-1.2	-0.2	-1.0	-1.7
Myopia	0.7	1.0	3.5	1.9	0.9	1.4	-0.4	-0.3	0.3	0.5
Basal cell carcinoma (self-reported)	0.7	0.8	1.7	-1.0	-0.9	1.0	-0.4	-1.3	-0.7	-0.6
Coronary Artery Disease (CAD)	0.6	0.7	2.7	0.4	0.6	-0.2	1.6	0.4	0.6	1.1
Lupus	0.6	0.9	3.1	0.8	0.9	-0.8	0.3	1.8	0.9	0.6
Triglycerides	0.6	0.9	2.0	0.0	-0.9	0.7	-1.4	-0.8	-1.1	-1.1
High blood pressure (mother)	0.6	0.8	2.5	1.6	1.0	1.2	0.4	-0.0	0.3	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.2	0.1	-0.8	1.1	-0.9	-1.0	-1.5	-0.9
Happiness	0.6	0.8	2.3	0.0	-0.9	0.7	-0.3	-0.5	-1.5	-1.2
Breastfed as a baby	0.6	0.7	1.9	0.6	0.7	-1.4	0.5	0.9	0.5	0.8
Tense / ‘highly strung’	0.6	1.0	2.6	-0.5	0.4	-1.3	1.2	1.6	0.9	0.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	3.0	-1.7	-1.4	-0.6	-0.2	0.1	-1.0	-1.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	-0.5	-0.9	0.8	-0.5	-0.4	-1.1	-1.2
Pulse wave peak to peak time	0.6	0.7	1.5	-1.2	-0.8	0.9	-0.2	-0.4	-0.3	-1.2
Angina (self-reported)	0.6	0.8	2.6	0.8	0.9	-0.3	1.6	0.2	0.6	1.0
Medication: Seretide 50 evohaler	0.6	0.7	1.6	-0.6	-0.6	1.3	-0.9	-1.0	-0.3	-1.0
Number of full sisters	0.6	0.8	1.8	0.5	1.1	-0.2	1.3	0.7	0.8	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.6	1.0	0.3	1.3	-1.0	-0.6	-0.6	-0.6
Eye problems/disorders: Cataract	0.6	0.7	1.5	-1.0	-0.5	1.2	-0.0	-1.0	-0.7	-0.6
Number of operations (self-reported)	0.6	0.9	1.4	0.5	1.0	-0.8	0.8	1.2	1.1	0.9
Ulcerative Colitis	0.5	0.8	2.3	-0.1	-0.9	0.4	-1.2	-0.5	-1.5	-0.7
Blood White Count	0.5	3.8	6.5	-0.9	-1.6	2.2	-2.4	-2.5	-1.6	-1.8
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.6	-0.7	-0.8	1.1	-0.0	-0.8	-1.3	-0.8
Forced vital capacity (FVC)	0.5	1.8	2.8	-0.8	-1.3	1.3	-1.1	-1.7	-1.6	-1.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.9	-1.7	-1.4	-0.8	0.1	-1.0	-0.8	-0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.9	0.6	-0.3	0.6	-1.4	-0.4	-0.9	-0.9
Forced vital capacity (FVC), Best measure	0.5	1.9	3.0	-1.4	-1.7	0.8	-0.7	-1.3	-1.7	-1.6
Number of full brothers	0.5	0.6	2.6	-0.3	-0.4	-0.4	-1.6	-0.4	-0.4	-0.9
Medication for pain relief, constipation, heartburn	0.5	0.8	2.6	0.4	-0.5	1.6	-1.1	-0.8	-0.9	-0.5
Had major operations	0.5	0.6	1.0	1.0	0.9	-0.5	0.8	0.7	0.5	0.8
Leg pain on walking	0.5	0.6	1.8	-0.5	-0.1	-1.0	-0.6	1.3	-0.4	-0.8
Supplements: Vitamin C	0.5	0.5	1.5	0.4	0.4	-1.1	-1.2	0.1	0.8	0.3
Smoking status: Current	0.5	0.7	1.7	-0.3	-0.5	1.3	-0.8	-0.9	-1.0	-0.8
Leg fat percentage (left)	0.5	1.8	4.2	-0.1	1.2	-0.5	1.6	1.2	2.1	1.5
Average weekly beer plus cider intake	0.5	0.7	1.8	0.4	-0.4	0.8	-1.3	-0.6	-1.0	-0.9
Diastolic blood pressure, automated reading	0.5	1.5	3.8	0.1	1.0	-1.3	1.9	1.1	1.0	1.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.0	-1.7	-1.6	-0.4	-1.0	-0.3	-0.9	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.7	1.6	1.0	0.5	-0.4	0.2	0.0	0.3
Bipolar Disorder or Schizophrenia	0.4	1.0	1.8	-0.8	-1.1	0.1	-1.2	-0.9	-1.3	-1.1
Ovarian Cancer	0.4	0.5	1.5	0.3	0.8	-0.7	0.3	1.2	0.7	0.1
HbA1C	0.4	0.5	0.8	-0.9	-0.7	0.7	0.0	-0.7	-0.7	-0.8
Neuroticism	0.4	1.0	2.4	-1.3	-1.1	0.0	-1.1	-0.0	-0.8	-1.6
Average weekly spirits intake	0.4	0.5	1.1	-1.0	-0.7	0.5	-0.6	-0.2	-0.8	-1.1
Relative age of first facial hair	0.4	0.8	1.8	-0.8	-1.0	-1.3	-1.2	-0.0	-0.2	-0.9
Ever had hysterectomy (womb removed)	0.4	0.4	1.5	-1.2	-0.4	0.2	-0.8	0.1	0.2	-0.7
Pack years adult smoking proportion	0.4	0.5	1.5	0.6	0.7	0.7	1.2	0.3	0.5	0.8
Average weekly fortified wine intake	0.4	0.5	2.3	1.5	0.9	0.2	-0.1	0.3	-0.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.8	1.3	0.5	1.1	-0.4	0.1	-0.4	0.1
Waist circumference	0.4	1.4	3.4	-0.4	0.9	-0.5	1.8	1.1	1.6	1.2
Had menopause	0.4	0.6	1.9	-1.4	-0.9	0.3	-0.4	-0.7	-0.4	-0.5
Pain all over the body in last month	0.4	0.4	1.0	0.2	0.3	0.5	0.9	-1.0	-0.0	0.7
Medication: Ramipril	0.4	0.5	1.6	0.9	0.4	1.3	-0.6	-0.8	-0.3	0.2
Father’s age at death	0.4	0.5	0.8	0.8	0.9	-0.0	0.8	0.3	0.7	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	1.9	-1.2	-1.4	0.6	0.0	-1.1	-1.4	-1.1
Medication: Allopurinol	0.4	0.6	2.7	0.1	-0.1	1.6	0.3	-1.1	0.3	0.2
Arm predicted mass (right)	0.4	1.9	4.6	-2.1	-1.7	1.1	-0.6	-1.2	-1.2	-1.3
Overall health rating	0.4	0.9	1.5	-1.0	-0.8	1.1	-0.3	-1.0	-0.9	-1.2
Illnesses of siblings: Diabetes	0.4	0.6	1.4	0.2	0.7	-0.8	1.2	0.3	0.5	0.9
Smoking status: Previous	0.4	0.5	1.4	-1.2	-0.2	-1.1	-0.3	0.6	0.7	-0.3
Diabetes diagnosed by doctor	0.4	0.7	3.1	0.3	-0.1	1.8	0.2	-1.2	-0.3	-0.5
Friendships satisfaction	0.4	0.5	1.7	1.3	0.6	-0.1	-0.5	1.1	0.1	-0.3
Medication for cholesterol	0.4	0.6	1.5	1.1	0.8	-0.4	0.2	1.2	0.5	0.5
Average weekly champagne plus white wine intake	0.4	0.5	1.3	-1.0	-0.6	-0.4	-1.1	-0.2	-0.4	-0.9
Hearing aid user	0.4	0.5	1.7	0.2	0.2	-0.8	-0.6	1.3	-0.4	-0.5
High cholesterol (Self-reported)	0.4	0.7	2.9	-1.7	-0.8	0.4	-0.4	-0.9	-0.3	-0.6
Ever smoked	0.4	0.6	1.2	-1.1	-0.7	0.5	-1.1	-0.7	-0.3	-1.0
Ever depressed for a whole week	0.4	0.5	1.1	0.1	-0.5	0.1	-0.9	-0.2	-1.0	-1.0
Commuting to job workplace: Cycle	0.4	0.5	1.7	1.3	0.9	0.0	0.5	0.7	-0.2	0.4
Alcohol drinker status: Previous	0.4	0.5	1.4	0.3	-0.4	1.2	0.1	-0.7	-0.8	-0.7
Schizophrenia vs Biploar Disorder	0.3	0.4	1.3	0.6	0.1	1.1	-0.9	-0.3	-0.0	0.1
Systolic Blood Pressure	0.3	1.6	3.5	0.3	0.9	-1.9	1.1	1.5	1.3	1.3
Hand grip strength (left)	0.3	0.8	1.9	-0.3	-0.7	0.8	-0.9	-1.0	-1.4	-0.9
Systolic blood pressure, automated reading	0.3	0.8	2.2	-0.3	0.4	-1.2	1.5	0.9	0.5	0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.3	-1.1	-0.5	-0.3	0.4	0.4	0.6	-0.3
Hand grip strength (right)	0.3	0.9	1.6	-0.8	-1.1	0.5	-0.7	-0.9	-1.3	-1.0
Current tobacco smoking	0.3	0.4	1.4	-0.2	-0.3	1.2	-0.5	-0.7	-0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	-0.1	-0.7	0.2	-0.6	-0.8	-1.2	-1.0
High blood pressure	0.3	0.8	2.0	1.4	1.3	0.9	0.4	0.1	0.6	0.8
Supplements: Glucosamine	0.3	0.3	2.1	0.1	-0.1	1.4	-0.2	-0.2	-0.5	0.1
Medication: Levothyroxine sodium	0.3	0.5	1.5	-0.3	-0.0	-1.2	0.4	1.2	0.3	-0.0
Past tobacco smoking	0.3	0.6	1.6	1.3	0.7	0.5	1.0	-0.1	-0.1	0.9
Alcohol usually taken with meals	0.3	0.5	1.8	-0.9	-0.0	-1.3	0.4	0.1	0.7	0.7
Nervous feelings	0.3	0.6	1.9	-1.4	-0.7	-0.9	0.2	0.5	-0.3	-0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	-0.5	-0.5	-0.7	-0.4	0.2	-0.5	-0.9
Qualifications: None of the above	0.3	0.5	1.8	-0.3	0.7	-0.4	1.3	0.4	0.6	0.8
Financial difficulties in last 2 years	0.3	0.5	2.1	-0.3	-0.4	1.4	-0.4	-0.7	-0.1	-0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	-0.3	0.5	-0.9	0.6	0.6	0.7	0.6
Arm fat percentage (right)	0.3	1.1	2.7	0.3	1.1	0.3	1.6	0.6	1.5	1.2
Worrier / anxious feelings	0.3	0.5	1.7	0.1	-0.4	0.5	-1.3	-0.0	-0.6	-0.9
Noisy workplace	0.3	0.4	0.9	0.1	0.3	-1.0	0.7	0.8	0.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.6	-0.9	-0.1	-1.3	0.2	0.6	-0.3	-0.4
Standing height	0.3	3.0	4.8	-1.2	-1.8	1.3	-2.0	-1.6	-2.2	-1.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.4	0.5	-0.3	0.2	-1.2	0.0	-0.7	-0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.4	-0.8	-0.2	-1.2	0.9	-0.3	0.6	0.4
Blood clot in the leg (DVT)	0.3	0.4	1.5	1.2	0.6	0.6	-0.5	-0.0	-0.2	-0.1
Medication: Paracetamol	0.3	0.5	1.2	-0.3	-0.8	0.4	-1.1	-0.2	-0.7	-1.1
Headache pain in last month	0.3	0.5	1.3	-1.1	-0.9	-0.4	0.1	-0.0	-0.3	-0.9
Worry too long after embarrassment	0.3	0.5	1.4	-1.2	-0.7	-0.3	-0.8	-0.1	-0.4	-0.8
Age at first live birth	0.3	0.6	1.9	1.4	0.9	-0.3	0.5	0.8	-0.3	0.4
Health satisfaction	0.3	0.4	1.1	1.1	0.2	-0.8	-0.2	0.7	-0.4	-0.2
Qualifications: College or University degree	0.3	0.8	1.7	-1.1	-1.3	0.3	-0.2	-0.9	-1.1	-1.0
Neck or shoulder pain in last month	0.3	0.4	1.3	0.2	0.3	-1.1	-0.1	1.0	0.3	-0.1
Leg fat mass (right)	0.3	1.3	2.9	0.2	1.1	0.0	1.7	0.9	1.7	1.3
Hypertension (Self-reported)	0.3	0.7	1.7	1.1	1.0	1.3	0.7	-0.4	0.5	0.7
Leg fat-free mass (right)	0.3	1.4	2.4	-1.0	-1.3	1.5	-0.5	-1.4	-1.2	-1.1
Average weekly red wine intake	0.3	0.4	1.2	-0.2	0.0	-1.0	0.6	1.1	-0.0	-0.0
Mineral and other dietary supplements	0.3	0.4	1.5	0.4	0.2	-1.2	0.3	0.9	0.1	-0.1
Osteoarthritis (self-reported)	0.3	0.4	2.1	0.6	0.3	1.4	-0.5	-0.5	0.2	0.2
Medication: Gliclazide	0.3	0.3	1.1	0.1	-0.2	1.1	-0.4	-0.6	-0.3	-0.6
Leg predicted mass (right)	0.3	1.5	2.5	-1.0	-1.3	1.6	-0.6	-1.4	-1.2	-1.2
Medication: Blood pressure	0.3	0.6	1.1	-0.3	-0.7	0.6	-1.0	-0.9	-0.8	-0.7
Alcohol drinker status: Never	0.3	0.4	1.8	-0.2	-0.2	-1.3	0.4	0.8	0.0	0.1
Risk taking	0.3	0.4	1.0	-0.3	0.3	-0.2	0.8	0.6	1.0	0.8
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	0.6	0.2	0.9	-0.9	-0.2	-0.2	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	2.1	-0.4	0.2	0.2	1.4	-0.1	0.1	0.5
Age started oral contraceptive pill	0.3	0.4	1.2	-1.1	-0.3	-0.3	0.7	0.7	-0.2	-0.3
Bipolar Disorder (2018)	0.2	0.4	1.4	-0.6	-0.1	-1.2	0.9	0.2	-0.1	0.1
Crohns Disease (2017)	0.2	0.5	2.1	1.5	0.6	-0.1	-0.6	0.1	0.4	0.9
Irritable Bowel Disease (IBD)	0.2	0.4	1.9	1.0	0.0	-0.3	-1.4	0.2	-0.3	0.3
Ulcerative Colitis (UC)	0.2	0.5	2.2	0.3	-0.6	-0.1	-1.5	-0.1	-0.7	-0.3
Major Depression (MDD)	0.2	0.2	0.5	-0.3	-0.2	-0.7	-0.1	0.6	-0.5	-0.6
Reaction Time	0.2	0.3	0.8	-0.7	-0.3	-0.1	-0.9	-0.8	-0.1	-0.7
Crohns Disease (2012)	0.2	0.4	1.4	1.2	0.3	0.1	0.4	-0.5	-0.2	0.7
Mean Putamen Volume	0.2	0.3	0.8	-0.2	0.3	-0.6	0.9	0.0	0.5	0.5
Fasting Glucose	0.2	0.3	0.7	0.9	0.1	-0.4	-0.7	0.6	0.4	0.3
Rheumatoid Arthritis	0.2	0.2	0.7	0.2	-0.0	0.8	-0.3	0.0	-0.8	-0.5
Schizophrenia (2014)	0.2	0.4	1.6	0.0	-0.5	0.2	-1.3	-0.6	-0.5	-0.5
Heel T-Score	0.2	1.7	3.1	1.8	1.2	-1.1	0.7	1.1	1.2	1.8
Waist Hip Ratio (WHR)	0.2	0.8	1.5	-0.2	0.6	-0.8	1.1	1.1	1.2	0.8
Hypothyroidism (self reported)	0.2	0.4	1.0	-1.0	-0.6	-0.8	0.8	0.3	0.0	0.1
Chronotype (morning person)	0.2	0.4	1.6	1.3	0.6	0.7	0.1	-0.4	-0.1	0.4
Tanning	0.2	2.3	4.6	-0.2	-1.2	1.7	-2.1	-1.9	-1.3	-1.3
Number of treatments/medications taken	0.2	0.3	0.9	-0.5	0.4	0.1	0.7	0.1	0.9	0.5
Sensitivity / hurt feelings	0.2	0.3	1.7	-1.3	-0.4	0.1	-0.1	0.0	0.1	-0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	-0.6	-0.6	0.3	0.6	-0.4	-0.7	-0.4
Diabetes (father)	0.2	0.2	0.5	-0.2	-0.5	0.7	0.1	-0.4	-0.7	-0.4
Maternal smoking around birth	0.2	0.3	0.9	-0.7	-0.5	0.6	-0.9	-0.1	-0.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.9	-1.0	-0.6	-0.3	0.4	0.4	0.2	-0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.3	-0.4	-0.6	0.3	0.1	-0.5	-0.7
Medication: Atenolol	0.2	0.3	0.7	0.2	-0.1	0.8	-0.6	-0.8	-0.4	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.3	1.0	0.2	0.1	1.0	0.3	-0.6	-0.7	-0.2
Body mass index (BMI)	0.2	1.0	3.0	-0.3	0.7	-0.2	1.7	0.6	1.3	1.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.9	-0.1	-0.2	0.9	0.0	-0.8	0.2	-0.0
Mouth/teeth dental problems	0.2	0.4	1.7	0.3	-0.3	-1.3	-0.6	-0.1	-0.4	0.1
Trunk fat-free mass	0.2	1.2	3.3	-1.8	-1.3	0.7	-0.2	-0.8	-1.0	-1.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.6	-0.4	-0.7	0.8	0.1	-1.3	-1.0	-0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	1.6	-0.3	0.2	0.7	1.3	0.4	0.3	0.1
Medication: Cholesterol lowering	0.2	0.4	1.1	1.1	0.6	0.6	-0.8	-0.0	-0.2	-0.2
Trunk predicted mass	0.2	1.2	3.2	-1.8	-1.3	0.6	-0.3	-0.8	-1.0	-1.1
Length of working week for main job	0.2	0.2	0.6	-0.2	-0.6	0.4	-0.2	-0.8	-0.1	-0.3
Peak expiratory flow (PEF)	0.2	0.5	0.8	-0.3	-0.7	0.5	-0.8	-0.7	-0.7	-0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	0.2	0.5	0.0	0.7	0.6	0.7	0.3
High blood pressure (siblings)	0.2	0.3	0.8	-0.5	-0.4	0.3	-0.1	-0.9	-0.8	-0.6
Body fat percentage	0.2	0.6	1.7	0.0	0.8	0.4	1.0	0.4	1.3	0.9
Arm fat-free mass (right)	0.2	1.3	3.6	-1.9	-1.4	0.8	-0.3	-0.8	-0.9	-1.0
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.3	-0.2	0.5	-0.0	-0.7	-0.6	-0.1
Medication: Ibuprofen	0.2	0.3	1.2	-0.5	0.3	-1.1	0.4	0.6	0.0	0.0
Medication: Omeprazole	0.2	0.3	0.6	0.2	0.4	0.2	0.8	-0.8	0.0	0.6
Heart disease (mother)	0.2	0.2	0.5	0.4	0.6	0.0	0.7	0.1	0.3	0.4
Suffer from ‘nerves’	0.2	0.3	0.9	0.1	-0.0	0.6	-1.0	0.1	-0.6	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	-0.4	-0.5	0.7	-0.3	-0.6	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	-0.7	-0.8	0.3	0.0	-0.3	-0.6	-0.9
Whole body fat-free mass	0.2	1.0	2.1	-1.4	-1.2	1.0	-0.1	-0.9	-0.9	-0.9
Arm fat percentage (left)	0.2	0.8	1.9	0.3	0.9	0.3	1.4	0.4	1.3	1.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.6	0.7	-0.1	-0.0	0.2	0.6	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	-0.8	-0.4	1.0	0.1	-0.4	-0.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.7	-0.5	-0.1	0.6	-0.3	-0.2	0.2
Breast cancer (self-reported)	0.2	0.3	1.1	0.4	0.0	-1.0	0.1	0.8	-0.2	-0.2
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	-0.8	-0.1	0.8	0.7	-0.3	0.3	0.0
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	0.0	0.4	-0.5	0.5	0.6	0.5	0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.4	-0.1	-0.6	0.3	0.6	0.7	0.3
Medication: Lisinopril	0.2	0.3	0.9	-0.9	-0.4	0.1	0.1	0.2	-0.6	-1.0
Arm fat-free mass (left)	0.2	0.9	3.4	-1.8	-1.1	0.5	-0.1	-0.4	-0.7	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.1	-0.3	0.0	0.7	0.3	-1.0	-0.1	0.1
Pain experienced in last month	0.2	0.4	1.6	0.4	0.2	1.2	-0.3	-0.9	-0.3	-0.1
Pack years of smoking	0.2	0.3	0.8	0.4	0.5	0.7	0.9	0.1	0.2	0.5
Leg fat mass (left)	0.2	0.9	2.3	0.0	0.8	0.4	1.5	0.5	1.4	1.1
Age at First Birth	0.1	0.1	0.4	0.2	-0.4	-0.7	0.0	-0.1	-0.6	-0.2
HDL Cholesterol	0.1	0.2	0.5	-0.0	0.5	0.2	0.7	-0.0	0.0	0.5
Height	0.1	1.0	2.4	-0.8	-0.7	0.6	-1.5	-0.7	-1.1	-1.2
Smoking Status	0.1	0.3	1.4	-1.2	-0.5	-0.1	-0.4	-0.2	0.1	-0.6
Cardiovascular Disease	0.1	0.3	0.9	-0.3	-0.1	1.0	0.1	-0.8	-0.0	-0.0
Lung FEV1/FVC ratio	0.1	0.7	2.0	0.5	0.6	0.2	1.4	-0.8	0.8	1.0
Medication for hormone replacement therapy	0.1	0.1	0.3	0.3	0.4	0.2	-0.0	-0.2	0.5	0.3
Diabetes (mother)	0.1	0.1	0.3	0.1	-0.1	0.6	0.3	-0.2	-0.2	0.0
Impedance of leg (right)	0.1	0.4	0.7	0.6	0.7	-0.6	-0.1	0.8	0.6	0.5
Leg fat-free mass (left)	0.1	0.8	1.4	-0.8	-0.9	1.2	-0.2	-1.1	-0.8	-0.8
Trunk fat percentage	0.1	0.3	0.9	-0.2	0.3	0.9	0.6	-0.4	0.7	0.4
Taking other prescription medications	0.1	0.2	0.6	-0.2	0.2	-0.6	0.5	0.8	0.5	0.2
Age when periods started (menarche)	0.1	0.1	0.4	0.1	0.0	-0.1	-0.7	0.2	-0.3	-0.5
Leg predicted mass (left)	0.1	0.7	1.3	-0.8	-0.9	1.2	-0.2	-1.1	-0.8	-0.7
Trunk fat mass	0.1	0.3	1.0	-0.5	-0.0	1.0	0.6	-0.5	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.4	-0.1	-0.2	0.2	-0.1	-0.7	-0.3	-0.5
Medication: Simvastatin	0.1	0.1	0.7	-0.1	0.3	0.3	-0.8	0.1	-0.2	-0.2
Fluid intelligence score	0.1	0.1	0.3	0.5	0.3	0.5	0.5	-0.1	0.1	0.3
Impedance of arm (right)	0.1	0.5	1.5	1.2	0.3	0.8	-0.9	-0.3	-0.4	-0.2
Hip circumference	0.1	0.4	1.4	-0.1	0.4	-0.0	1.2	0.6	0.8	0.6
Time employed in main current job	0.1	0.1	0.2	0.1	0.4	-0.4	0.3	-0.2	0.3	0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.5	-0.5	-0.4	0.7	-0.1	-0.4	0.1	-0.7
Number of live births	0.1	0.2	0.5	0.3	0.1	0.7	-0.5	-0.3	-0.3	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.4	-0.3	0.1	-0.4	-0.3	0.1	-0.6
Medication: Lansoprazole	0.1	0.1	0.4	0.2	-0.2	0.3	-0.6	-0.1	-0.3	-0.3
Impedance of arm (left)	0.1	0.4	1.0	1.0	0.0	0.7	-0.9	-0.6	-0.5	-0.2
Arm fat mass (right)	0.1	0.4	1.4	-0.4	0.3	0.6	1.2	0.0	0.8	0.5
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.4	0.2	0.1	-0.1	0.1	0.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.0	0.4	0.5	0.4	-0.4	0.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.5	0.7	0.1	-0.0	-0.4	-0.0	-0.3	0.1
Shortness of breath walking on level ground	0.1	0.1	0.4	0.1	-0.0	0.3	-0.4	-0.6	-0.4	-0.5
Mean time to correctly identify matches	0.1	0.2	0.6	-0.0	0.7	-0.2	-0.1	-0.3	0.8	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.6	0.8	0.2	0.3	-0.1	-0.0	0.1	0.3
Whole body fat mass	0.1	0.3	0.6	-0.5	0.2	0.8	0.7	-0.2	0.7	0.4
Alcohol intake frequency.	0.1	0.1	0.4	-0.3	-0.2	-0.2	-0.0	0.5	-0.1	-0.7
Comparative height size at age 10	0.1	0.7	1.9	-0.3	-0.5	1.4	-1.1	-1.1	-0.4	-0.4
Age at last live birth	0.1	0.2	0.4	0.2	-0.0	-0.5	-0.3	0.6	-0.5	-0.4
Medication: Aspirin	0.1	0.1	0.3	0.1	0.5	-0.2	0.2	0.0	0.6	0.3
Knee pain experienced in last month	0.1	0.2	0.7	-0.1	-0.1	-0.8	-0.1	0.8	0.2	-0.0
Long-standing illness, disability or infirmity	0.1	0.2	0.8	-0.9	-0.3	-0.0	0.5	0.0	-0.1	-0.2
Commuting to job workplace: Walk	0.1	0.1	0.2	0.1	0.2	0.5	0.5	-0.1	0.1	0.3
Medication: Aspirin	0.1	0.2	0.4	0.3	0.6	-0.3	0.3	0.2	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	0.5	-0.0	-0.2	-0.2	-0.6	-0.3	0.3
Whole body water mass	0.1	0.8	2.0	-1.4	-1.1	0.8	-0.1	-0.8	-0.8	-0.8
Arm fat mass (left)	0.1	0.4	1.1	-0.5	0.2	0.5	1.0	-0.1	0.8	0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.5	-0.3	-0.2	-0.7	-0.3	0.2	0.0	-0.3
Commuting to job workplace: Public transport	0.1	0.2	0.2	0.4	0.4	-0.4	-0.2	0.4	0.4	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.6	-0.3	0.1	-0.3	-0.3	0.1	0.8	0.4
Medication: Paracetamol	0.1	0.2	0.5	0.2	-0.3	-0.0	-0.7	0.4	-0.3	-0.7
Basal metabolic rate	0.1	0.8	1.8	-1.3	-1.0	0.9	-0.1	-0.8	-0.8	-0.8
Arm predicted mass (left)	0.1	0.5	2.3	-1.5	-0.8	0.2	0.1	-0.1	-0.4	-0.7
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.4	-0.4	-0.3	0.2	0.6	-0.1	-0.1	-0.1
Worry (Nagel 2018)	0.0	0.1	0.2	-0.4	-0.2	-0.1	-0.0	0.2	-0.2	-0.4
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.3	-0.2	-0.2	0.3	0.5	0.1	-0.2	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.1	0.2	0.5	0.3	0.2	0.0	-0.0	0.1	-0.1
BMI	0.0	0.3	0.5	-0.7	-0.1	0.6	0.5	-0.6	0.7	0.1
Lung FVC	0.0	0.2	0.4	0.2	0.3	-0.5	0.5	0.6	0.3	0.3
Hair Pigment	0.0	0.8	2.3	0.5	0.1	1.3	-1.5	-1.2	-0.0	-0.2
Impedance of leg (left)	0.0	0.1	0.3	-0.0	-0.0	0.3	-0.6	0.0	-0.1	-0.2
Weight	0.0	0.2	0.8	-0.9	-0.2	0.5	0.6	-0.1	0.2	0.0
Glaucoma (self-reported)	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.3	0.1	0.2	0.0
Illnesses of father: High blood pressure	0.0	0.0	0.1	0.1	-0.1	-0.3	0.0	-0.1	-0.2	-0.2
Impedance of whole body	0.0	0.2	0.6	0.7	0.1	0.4	-0.8	-0.2	-0.2	-0.1

Hub : Genes

KLRC4

Models

Trait associations