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chr14:103,108,478-106,199,579

Best TWAS P=6.7e-20 · Best GWAS P=1.46e-20 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EIF5	0.07	0.04	lasso	7	0.03	9.7e-05	-5.2	5.6	1.9e-08	-0.11	0.94	0.01	TRUE
2	GTEx	Adipose Subcutaneous	BTBD6	0.08	0.05	lasso	6	0.05	7.0e-05	8.5	-7.9	3.2e-15	-0.85	0.08	0.87	FALSE
3	GTEx	Adrenal Gland	CKB	0.18	0.00	enet	16	0.02	6.9e-02	4.2	5.2	1.9e-07	0.02	0.04	0.46	FALSE
4	GTEx	Artery Aorta	TRMT61A	0.14	0.07	lasso	5	0.12	6.4e-07	-3.9	-5.4	7.1e-08	-0.03	0.05	0.94	TRUE
5	GTEx	Artery Aorta	BTBD6	0.13	0.10	lasso	4	0.09	1.3e-05	8.5	-8.3	6.9e-17	-0.94	0.24	0.73	FALSE
6	GTEx	Artery Aorta	BRF1	0.08	0.07	lasso	3	0.07	9.3e-05	8.5	8.3	1.5e-16	0.93	0.06	0.84	FALSE
7	GTEx	Artery Tibial	AKT1	0.11	0.00	enet	15	0.00	1.4e-01	2.7	6.3	3.1e-10	0.31	0.03	0.30	FALSE
8	GTEx	Artery Tibial	BTBD6	0.19	0.12	enet	19	0.15	9.1e-12	8.5	-7.9	2.4e-15	-0.90	0.03	0.97	FALSE
9	GTEx	Brain Cortex	CEP170B	0.24	-0.01	enet	29	0.02	1.2e-01	9.2	5.2	1.8e-07	0.32	0.02	0.56	FALSE
10	GTEx	Brain Cortex	XRCC3	0.12	0.02	lasso	4	0.01	1.7e-01	3.3	5.5	4.1e-08	-0.04	0.05	0.72	FALSE
11	GTEx	Brain Frontal Cortex BA9	APOPT1	0.17	0.07	lasso	3	0.08	4.6e-03	6.8	-6.2	4.5e-10	-0.04	0.03	0.86	TRUE
12	GTEx	Brain Hypothalamus	RPS20P33	0.23	0.11	lasso	4	0.07	8.6e-03	9.2	-9.1	1.2e-19	-0.99	0.01	0.77	FALSE
13	GTEx	Breast Mammary Tissue	BTBD6	0.11	0.14	lasso	3	0.12	7.9e-07	8.5	-8.5	2.6e-17	-0.93	0.21	0.77	FALSE
14	GTEx	Colon Sigmoid	BTBD6	0.19	0.11	lasso	2	0.08	1.1e-03	9.1	-8.6	8.1e-18	-0.99	0.01	0.96	FALSE
15	GTEx	Colon Transverse	KLC1	0.16	0.01	lasso	7	0.00	1.9e-01	4.9	5.2	2.4e-07	0.00	0.09	0.43	FALSE
16	GTEx	Colon Transverse	BAG5	0.14	0.05	lasso	10	0.02	4.8e-02	5.4	5.7	1.3e-08	-0.03	0.22	0.31	FALSE
17	GTEx	Colon Transverse	BRF1	0.18	0.07	enet	12	0.03	1.4e-02	8.5	8.4	2.9e-17	0.88	0.02	0.89	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	BTBD6	0.20	0.23	lasso	2	0.20	8.3e-08	8.6	-8.6	1.1e-17	-0.94	0.30	0.69	FALSE
19	GTEx	Esophagus Mucosa	MARK3	0.11	0.03	lasso	4	0.04	1.5e-03	-3.0	-5.3	1.1e-07	0.00	0.02	0.89	FALSE
20	GTEx	Esophagus Mucosa	BRF1	0.15	0.10	lasso	3	0.11	4.8e-08	9.3	9.1	1.3e-19	0.97	0.00	1.00	FALSE
21	GTEx	Esophagus Muscularis	BTBD6	0.24	0.17	lasso	4	0.16	6.1e-10	8.6	-8.5	1.3e-17	-0.94	0.59	0.41	FALSE
22	GTEx	Esophagus Muscularis	APOPT1	0.16	0.02	enet	11	0.04	2.2e-03	-4.2	-5.8	8.8e-09	0.04	0.07	0.75	FALSE
23	GTEx	Heart Left Ventricle	BTBD6	0.13	0.02	enet	12	0.07	1.7e-04	8.6	-7.2	5.9e-13	-0.87	0.04	0.83	FALSE
24	GTEx	Nerve Tibial	KLC1	0.07	0.00	enet	22	0.01	8.5e-02	5.4	5.2	2.3e-07	-0.03	0.09	0.73	TRUE
25	GTEx	Nerve Tibial	BTBD6	0.08	0.02	lasso	3	0.01	1.1e-01	8.5	-8.3	6.9e-17	-0.91	0.04	0.33	FALSE
26	GTEx	Skin Sun Exposed Lower leg	BRF1	0.12	0.07	lasso	4	0.07	2.8e-06	8.8	8.8	1.7e-18	0.98	0.07	0.93	FALSE
27	GTEx	Spleen	KLC1	0.15	0.05	lasso	3	0.03	6.4e-02	6.8	6.7	2.4e-11	0.02	0.03	0.68	FALSE
28	GTEx	Testis	BTBD6	0.12	0.07	lasso	3	0.06	9.6e-04	9.2	-9.1	1.2e-19	-0.99	0.01	0.98	FALSE
29	GTEx	Testis	BRF1	0.22	-0.01	lasso	5	0.01	8.0e-02	1.2	6.2	6.7e-10	0.65	0.02	0.66	FALSE
30	GTEx	Thyroid	BRF1	0.21	0.09	enet	24	0.14	1.6e-10	-2.3	5.7	1.4e-08	0.64	0.76	0.24	FALSE
31	METSIM	Adipose	TDRD9	0.08	0.04	lasso	10	0.06	1.9e-09	4.9	-6.4	2.0e-10	0.03	0.52	0.48	FALSE
32	YFS	Blood	BTBD6	0.07	0.07	lasso	6	0.07	8.5e-22	8.5	-8.6	1.0e-17	-0.94	0.73	0.27	FALSE
33	YFS	Blood	EIF5	0.11	0.09	enet	29	0.10	1.5e-29	-5.4	-6.4	1.4e-10	0.11	1.00	0.00	TRUE
34	The Cancer Genome Atlas	Glioblastoma Multiforme	MARK3	0.12	0.05	blup	64	0.07	3.3e-03	-3.9	-5.3	1.3e-07	-0.04	0.03	0.10	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUDT14	0.06	0.02	enet	8	0.06	3.2e-07	3.1	-5.7	1.6e-08	-0.13	0.01	0.99	TRUE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	BTBD6	0.02	0.03	lasso	2	0.02	9.2e-04	8.5	8.6	9.0e-18	0.94	0.04	0.94	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf153	0.04	0.01	blup	38	0.03	6.2e-04	4.8	-5.7	1.3e-08	-0.01	0.10	0.09	TRUE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf153	0.06	0.02	blup	38	0.04	2.4e-05	-2.6	-5.6	2.6e-08	-0.01	0.25	0.07	FALSE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	BTBD6	0.10	0.01	blup	37	0.03	1.3e-02	8.6	6.4	1.7e-10	0.76	0.01	0.52	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	CKB	0.07	0.09	blup	32	0.10	1.1e-10	6.8	-6.8	1.0e-11	-0.01	0.85	0.15	TRUE
41	The Cancer Genome Atlas	Rectum Adenocarcinoma	BRF1	0.18	0.20	lasso	2	0.13	6.1e-04	9.1	9.1	7.0e-20	0.99	0.01	0.91	FALSE
42	The Cancer Genome Atlas	Rectum Adenocarcinoma	BTBD6	0.17	0.17	lasso	3	0.11	1.5e-03	9.1	9.1	6.7e-20	0.99	0.01	0.91	TRUE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	BTBD6	0.04	0.00	blup	38	0.03	1.7e-03	8.5	8.2	2.7e-16	0.84	0.01	0.48	FALSE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	C14orf153	0.20	0.05	lasso	2	0.04	8.8e-04	6.8	-6.6	5.1e-11	-0.05	0.05	0.05	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	BRF1	0.06	0.02	blup	47	0.07	2.0e-07	-2.2	5.8	5.9e-09	0.63	0.73	0.24	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	BTBD6	0.15	0.10	lasso	9	0.14	3.3e-13	8.5	6.5	7.0e-11	0.74	0.49	0.51	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	KLC1	0.04	0.01	blup	82	0.03	5.4e-04	4.9	5.4	6.6e-08	-0.01	0.15	0.06	TRUE