Hub : Genes

EIF5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.071	0.0270	0.00045	0.037	0.025	0.020	0.023	0.031	2.5e-05	4.4e-04	1.5e-03	6.6e-04	9.7e-05
2	GTEx	Ovary	0.425	0.1810	0.00076	0.012	NA	0.051	NA	0.098	1.6e-01	NA	2.2e-02	NA	2.2e-03
3	GTEx	Skin Sun Exposed Lower leg	0.060	0.0290	0.00610	0.030	NA	0.065	NA	0.068	1.5e-03	NA	4.8e-06	NA	2.9e-06
4	YFS	Blood	0.111	0.0234	0.00000	0.092	0.088	0.095	0.093	0.091	1.2e-28	2.3e-27	1.5e-29	8.0e-29	2.7e-28

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.8	2.9	6.2	1.6	-1.7	0.1	-2.5
Bipolar Disorder or Schizophrenia	5.3	13.0	24.4	4.3	-2.6	-1.6	-4.9
Depressed Affect (Nagel 2018)	1.1	2.2	3.7	1.9	-0.8	0.9	-1.9
Depression (Nagel 2018)	0.9	1.4	4.5	0.1	-2.1	-0.9	-0.3
Intelligence (Savage-Jansen 2018)	1.6	5.1	10.8	1.8	-1.2	3.3	-2.1
Neuroticism (Nagel 2018)	0.7	1.7	3.2	1.8	-0.5	1.0	-1.5
Schizophrenia (2018)	5.4	11.3	19.0	4.2	-2.0	-2.1	-4.4
Schizophrenia vs Biploar Disorder	0.3	0.4	1.5	-0.1	-1.2	-0.2	0.5
Worry (Nagel 2018)	1.1	2.4	5.1	2.3	-0.4	0.7	-1.9
Alzheimer’s Disease (in mother)	0.3	0.3	0.8	-0.6	-0.0	-0.9	0.2
Alzheimer’s Disease (in father)	1.0	1.1	3.1	-0.5	1.0	-1.8	-0.2
Alzheimer’s Disease (including proxy)	1.0	1.4	5.2	-0.7	0.3	-2.3	-0.1
Crohns Disease (2017)	1.3	2.9	7.6	0.1	-2.0	-2.8	0.1
Irritable Bowel Disease (IBD)	0.9	2.1	5.6	0.9	-1.2	-2.4	-0.8
Ulcerative Colitis (UC)	0.7	1.3	1.9	1.3	0.2	-1.4	-1.2
Major Depression (MDD)	1.7	2.1	4.1	2.0	-0.4	0.5	-2.0
Reaction Time	0.3	0.6	0.9	1.0	-0.5	-0.8	-0.7
Verbal and Numeric Reasoning (VNR)	1.4	3.2	4.5	2.1	-0.5	2.1	-2.0
Breast Cancer	1.6	3.8	10.6	1.2	-1.5	-3.2	-0.9
Ovarian Cancer	0.5	0.6	1.7	-0.9	-0.1	0.1	1.3
Prostate Cancer	0.5	0.7	1.7	0.3	-0.9	-1.3	-0.5
Age at First Birth	1.6	2.3	5.1	-1.9	0.1	0.6	2.3
Bipolar Disorder (2011)	3.2	3.1	5.4	2.2	-1.2	-0.6	-2.3
Body Mass Index (BMI) (2010)	1.8	2.5	4.9	0.8	-2.2	-2.0	-0.6
Coronary Artery Disease (CAD)	1.3	1.6	3.4	-1.8	1.0	-0.4	1.4
Crohns Disease (2012)	0.8	1.4	2.4	-0.8	-1.5	-1.2	1.0
Mean Putamen Volume	0.7	0.8	2.2	-0.8	0.6	1.5	0.4
Fasting Glucose	0.8	0.9	1.6	0.9	1.3	-0.4	-1.0
HbA1C	0.3	0.3	0.7	0.1	-0.3	0.8	-0.8
HDL Cholesterol	0.1	0.2	0.5	-0.2	0.7	-0.2	-0.6
LDL Cholesterol	0.6	0.9	3.4	0.4	-1.8	0.4	0.0
Lupus	0.4	0.6	1.4	0.5	-0.6	-1.2	-0.6
Neuroticism (2016)	3.0	4.3	8.2	2.9	1.2	1.3	-2.5
Primary Biliary Cirrhosis	0.5	0.8	1.5	1.2	0.5	-0.1	-1.2
Rheumatoid Arthritis	0.1	0.2	0.7	-0.0	0.8	0.2	0.1
Schizophrenia (2014)	5.9	13.0	22.0	4.5	-2.2	-2.2	-4.7
Triglycerides	0.6	1.0	2.3	0.2	-1.2	1.5	0.4
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.3	1.5	0.1	-0.7	-1.2
Ulcerative Colitis	0.6	0.8	1.5	1.0	-0.2	-1.2	-0.9
Blood Eosinophil Count	2.7	20.7	39.5	6.3	-2.2	-0.1	-6.2
Blood Platelet Count	0.7	7.6	15.4	-3.9	-0.2	-3.0	2.4
Blood Red Count	2.2	21.4	41.1	5.6	-3.4	-1.1	-6.4
Blood White Count	3.1	23.0	47.6	6.5	-1.3	0.2	-6.9
Heel T-Score	7.3	57.7	139.2	-0.6	-9.4	-11.8	-1.7
BMI	2.5	14.4	35.8	-1.3	-6.0	-4.3	1.2
Height	0.8	14.5	20.1	-3.4	3.6	4.5	3.7
Waist Hip Ratio (WHR)	0.1	0.4	0.8	-0.7	0.0	-0.9	-0.8
Systolic Blood Pressure	0.7	3.7	5.2	1.3	2.1	-1.9	-2.3
Smoking Status	1.4	3.4	5.9	1.6	-1.3	-1.8	-2.4
Allergy or Eczema	0.1	0.4	1.0	-0.7	-0.1	-0.2	1.0
Cardiovascular Disease	2.2	7.4	11.6	1.8	-2.8	-3.4	-2.6
Hypothyroidism (self reported)	0.6	1.3	2.6	1.6	-0.1	0.8	-1.5
Respiratory disease	1.3	3.0	7.1	0.7	-2.7	-1.5	-1.4
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.8	0.1	-2.0	-1.9	-0.8
Lung FEV1/FVC ratio	0.7	3.8	4.7	-1.3	2.1	2.2	2.1
Lung FVC	0.5	2.5	3.4	-1.8	-1.6	1.2	1.7
Neuroticism	0.7	1.8	2.6	1.6	-0.7	1.2	-1.6
Chronotype (morning person)	0.3	0.7	2.3	-0.3	-0.6	1.5	0.4
Hair Pigment	0.6	17.1	36.7	1.7	-5.1	-6.1	-1.6
Tanning	0.1	1.8	6.1	-0.9	2.5	0.2	0.4
Hand grip strength (left)	0.4	1.0	2.2	-1.5	0.3	0.2	1.3
Number of treatments/medications taken	0.9	1.6	5.2	0.0	-1.0	-2.3	-0.3
Average weekly spirits intake	3.3	4.1	8.0	-0.9	-2.8	-2.4	1.3
Sensitivity / hurt feelings	0.8	1.4	3.9	2.0	0.3	-0.1	-1.3
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.1	-0.5	-2.0	-1.5	0.6
Hearing difficulty/problems: Yes	1.9	2.9	10.4	0.4	-3.2	-0.6	-0.8
Relative age of first facial hair	0.9	1.9	3.0	1.1	-1.1	-1.7	-1.5
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	2.7	1.6	-0.9	-1.1	-1.6
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.8	-1.7	-0.9	-1.4	1.0
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	-0.6	-0.2	-0.9	0.7
Systolic blood pressure, automated reading	0.4	1.3	2.5	-0.5	1.6	-1.5	-0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	-0.0	-0.5	-0.7	-0.3
Angina	3.5	4.6	5.2	2.1	-2.2	-2.3	-2.1
Medication for hormone replacement therapy	1.1	1.2	2.0	-1.4	0.6	0.8	1.4
Vitamin and mineral supplements	0.9	1.2	1.6	-1.2	-1.3	-1.2	0.5
Supplements: Zinc	3.2	3.5	5.1	2.3	0.9	1.9	-2.1
Medication: Co-codamol	1.2	1.4	3.7	1.0	-1.9	-0.3	-0.9
Medication: Metformin	1.0	1.4	2.8	-0.6	-1.7	-1.5	0.5
Diabetes (father)	0.2	0.2	0.8	-0.3	0.0	0.9	0.1
Diabetes (mother)	0.4	0.5	0.8	0.7	-0.9	-0.8	-0.4
Severe depression (siblings)	2.0	2.2	4.4	2.0	-0.5	-0.5	-2.1
Pack years adult smoking proportion	1.3	2.0	4.6	-0.4	-2.1	-1.8	-0.1
Impedance of leg (right)	1.8	8.9	14.7	2.5	3.8	3.1	-2.2
Leg fat-free mass (left)	1.2	6.1	9.4	-2.4	-3.1	-1.8	2.4
Trunk fat percentage	1.3	5.3	14.0	-0.3	-3.7	-2.6	0.5
Hand grip strength (right)	1.1	3.0	6.0	-2.5	0.2	0.1	2.4
Townsend deprivation index at recruitment	0.5	0.6	0.8	0.7	-0.7	-0.9	-0.9
Current tobacco smoking	0.7	1.2	2.8	-0.5	-1.1	-1.7	-0.7
Average weekly fortified wine intake	0.3	0.4	0.8	0.4	0.7	0.9	-0.4
Maternal smoking around birth	3.9	5.7	16.0	1.0	-2.1	-4.0	-1.2
Fed-up feelings	0.8	1.4	2.8	1.7	-0.4	0.3	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.4	1.2	-1.2	-0.9	-0.6
Relative age voice broke	1.1	1.7	2.7	1.6	-1.0	-0.8	-1.6
Taking other prescription medications	1.7	2.6	4.5	1.3	-1.6	-2.1	-1.4
Age when periods started (menarche)	2.3	5.5	9.8	3.1	-1.0	-1.3	-3.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	-0.4	0.6	-0.8	0.5
Heel bone mineral density (BMD) T-score, automated (left)	4.1	9.2	23.1	-0.2	-3.6	-4.8	-0.8
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.5	-0.1	0.2	-0.7	0.3
Qualifications: CSEs or equivalent	0.3	0.3	0.7	-0.4	-0.8	0.0	0.7
Serious illness, injury or assault to yourself	2.4	3.0	7.0	1.6	-2.6	-0.6	-1.4
High blood pressure	2.1	5.7	9.2	2.0	-1.1	-3.0	-2.9
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	-0.6	-0.1	0.2	0.9
Multivitamins +/- minerals	1.3	1.6	2.2	1.5	1.5	0.9	-1.2
Stomach or abdominal pain in last month	0.4	0.5	0.8	-0.6	-0.9	-0.6	0.8
Supplements: Glucosamine	3.5	4.6	8.8	-3.0	-0.6	1.6	2.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.4	-0.2	-0.1	-0.2
Medication: Atenolol	0.3	0.4	0.8	0.3	-0.7	-0.9	-0.3
Medication: Levothyroxine sodium	0.3	0.4	1.2	1.1	0.3	0.2	-0.7
Sitting height	0.0	0.2	0.8	-0.1	0.2	0.9	0.2
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	0.2	0.4	-1.0	-0.3
High blood pressure (mother)	0.5	0.7	2.1	0.4	0.2	-1.4	-0.7
Body mass index (BMI)	2.3	10.0	24.2	-0.2	-4.9	-4.0	0.1
Impedance of leg (left)	1.8	8.7	18.0	2.2	4.2	2.8	-2.0
Leg predicted mass (left)	1.1	5.8	9.1	-2.3	-3.0	-1.8	2.3
Trunk fat mass	1.4	5.8	13.8	-0.9	-3.7	-2.8	1.0
Waist circumference	2.0	7.3	18.4	-1.1	-4.3	-3.0	0.7
Number of incorrect matches in round	0.6	1.1	1.6	-0.6	1.1	-1.3	1.0
Past tobacco smoking	1.0	1.8	2.5	-1.1	1.4	1.6	1.3
Alcohol usually taken with meals	0.9	1.5	4.0	0.9	-0.9	2.0	-0.6
Nervous feelings	0.1	0.3	0.4	0.6	-0.2	0.5	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.6	-0.8	-0.0	-0.4
Hearing difficulty/problems with background noise	4.4	7.0	24.1	0.8	-4.9	-1.3	-1.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	-0.5	-0.7	-0.0	0.2
Had menopause	1.9	2.4	4.9	-2.2	-0.7	-1.1	1.8
Had other major operations	1.0	1.2	2.3	1.5	-0.8	-0.4	-1.3
Forced vital capacity (FVC)	0.6	2.2	6.4	-0.6	-1.0	2.5	1.0
Heel bone mineral density (BMD) T-score, automated (right)	3.4	7.7	19.2	0.1	-3.2	-4.4	-1.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	1.2	-0.4	0.0	-0.6
Qualifications: None of the above	0.8	1.8	2.8	-1.1	1.4	-1.7	1.1
Financial difficulties in last 2 years	2.0	2.7	3.5	1.7	-1.6	-1.4	-1.9
Mouth/teeth dental problems	4.5	6.9	18.3	-0.7	4.3	2.9	0.8
Heart attack	0.6	0.7	2.5	0.5	-0.2	-1.6	-0.2
Allergy	0.2	0.5	1.5	-0.3	0.5	1.2	0.3
Pain all over the body in last month	1.8	2.0	6.2	0.9	0.1	-2.5	-0.9
Diabetes (self-reported)	1.8	2.8	4.9	0.7	-2.2	-2.0	-1.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.4	-1.1	-0.1	-0.5	1.2
Medication: Ramipril	1.4	1.8	3.3	1.0	-0.2	-1.8	-1.7
Medication: Simvastatin	0.8	1.1	2.1	-1.0	-0.8	-1.4	0.9
Fluid intelligence score	1.5	3.1	4.1	2.0	-1.5	1.5	-2.0
Illnesses of siblings	1.7	2.4	7.6	0.1	1.5	2.8	-0.1
Neuroticism score	1.2	2.5	5.3	2.3	0.0	0.6	-2.1
Weight	1.3	6.6	14.8	-1.7	-3.8	-2.4	1.7
Impedance of arm (right)	0.8	3.6	11.0	0.3	1.8	3.3	0.1
Arm fat percentage (right)	2.0	8.0	22.4	0.0	-4.7	-3.1	0.1
Trunk fat-free mass	0.6	3.7	5.8	-2.4	-1.4	-1.1	2.4
Hip circumference	1.4	6.0	19.2	-0.5	-4.4	-2.0	0.8
Time employed in main current job	0.5	0.5	1.0	-0.7	-0.5	-1.0	0.7
Alcohol intake versus 10 years previously	1.1	1.7	3.9	1.2	0.2	-2.0	-1.2
Father’s age at death	0.5	0.6	2.2	-0.1	-0.5	1.5	-0.1
Worrier / anxious feelings	0.6	1.1	1.6	1.1	1.3	0.2	-1.3
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	7.8	1.0	-2.8	-2.2	-1.2
Falls in the last year	0.8	1.0	1.8	1.2	-1.3	0.1	-0.9
Hair/balding pattern: Pattern 3	0.8	1.2	2.0	1.1	1.4	-0.6	-1.0
Number of live births	1.0	1.4	2.9	1.6	0.1	0.1	-1.7
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	7.0	-0.8	-0.5	2.6	1.5
Pulse rate	1.0	1.6	2.3	-1.5	-1.3	-1.0	1.3
Happiness	0.2	0.2	0.7	0.1	0.1	0.9	0.1
Noisy workplace	1.4	1.7	4.1	0.4	-2.0	-1.6	-0.3
Qualifications: A levels/AS levels or equivalent	1.7	3.8	6.3	2.1	-0.3	2.5	-2.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.8	0.1	0.4	2.0	0.3
Mouth/teeth dental problems: Dentures	2.3	3.9	11.8	-0.8	-1.7	-3.4	0.2
Asthma	1.1	2.1	4.1	0.5	-1.5	-2.0	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	1.8	0.7	-0.9	-1.3	-1.1
Medication: Cholesterol lowering	1.6	2.4	4.2	1.1	-1.7	-2.0	-1.2
Depression (self-reported)	0.6	0.8	1.5	0.9	-0.5	0.6	-1.2
Medication: Lansoprazole	1.0	1.2	3.7	-0.8	-1.9	-0.6	0.3
Prospective memory result	0.1	0.1	0.3	-0.5	0.2	-0.6	0.2
Lung cancer (father)	4.1	4.8	8.3	2.9	-1.8	-0.8	-2.6
Illnesses of mother	0.7	0.9	3.0	0.6	0.4	1.7	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	7.7	-1.3	-0.8	2.8	1.6
Pulse wave Arterial Stiffness index	1.3	1.6	4.5	0.9	-2.1	-0.6	-0.8
Impedance of arm (left)	0.6	2.9	8.2	0.1	1.9	2.9	0.2
Arm fat mass (right)	1.9	7.8	19.4	-0.7	-4.4	-3.2	0.8
Trunk predicted mass	0.7	3.7	5.9	-2.4	-1.4	-1.1	2.4
Standing height	0.8	7.6	10.8	-2.9	1.6	2.9	3.3
Length of working week for main job	0.3	0.4	0.5	0.7	-0.6	-0.1	-0.7
Exposure to tobacco smoke at home	3.7	4.2	5.9	2.0	-1.5	-2.4	-2.1
Breastfed as a baby	1.1	1.3	4.6	0.4	-0.0	2.2	-0.7
Tense / ‘highly strung’	3.9	6.5	13.7	3.7	0.0	1.3	-3.2
Seen doctor (GP) for nerves, anxiety, tension or depression	4.3	6.6	13.0	3.4	-1.3	0.7	-3.6
Hair/balding pattern: Pattern 4	1.1	2.8	3.7	1.6	-1.9	-1.2	-1.9
Birth weight of first child	0.5	1.0	2.8	-0.3	-1.7	0.9	0.5
Peak expiratory flow (PEF)	0.4	0.9	1.9	-0.7	-1.4	-0.3	1.1
Pulse wave reflection index	1.4	1.7	3.8	1.9	-0.3	-0.5	-1.6
Ever highly irritable/argumentative for 2 days	1.1	1.4	3.9	0.6	-0.9	-2.0	-0.6
Loud music exposure frequency	0.6	0.7	1.2	0.7	-1.1	-0.8	-0.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.6	1.3	-0.5	1.2	-1.0
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	6.0	1.2	-2.4	0.1	-0.8
Blood clot in the leg (DVT)	0.6	0.8	1.4	-1.2	-0.1	-0.6	1.1
Medication: Paracetamol	1.1	1.8	4.0	0.2	-2.0	-1.7	-0.2
Headache pain in last month	0.3	0.5	1.2	0.6	-1.1	-0.6	-0.1
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	5.0	-1.2	1.1	2.2	1.5
Glaucoma (self-reported)	1.6	1.9	4.4	-0.8	2.1	1.3	0.8
Gout (self-reported)	1.3	1.8	6.5	0.2	-0.9	-2.5	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.4	1.2	-0.5	-0.0	-0.9
Medication: Amlodipine	0.8	1.1	2.2	0.8	0.8	-1.5	-1.0
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.5	-0.1	-0.4	-0.7
Birth weight	2.7	5.8	11.3	-1.9	-0.0	3.4	2.9
Chronic bronchitis/emphysema (mother)	1.6	1.8	6.2	0.8	-0.1	-2.5	-0.7
High blood pressure (siblings)	2.3	3.4	10.6	0.7	-1.2	-3.3	-0.9
Forced vital capacity (FVC), Best measure	0.9	3.1	8.7	-0.8	-1.5	2.9	1.0
Body fat percentage	1.5	6.0	13.9	-0.0	-3.7	-3.2	0.1
Leg fat percentage (right)	1.3	4.8	9.9	0.9	-3.2	-2.8	-0.9
Arm fat-free mass (right)	0.7	3.5	4.2	-2.0	-1.7	-1.7	2.0
Exposure to tobacco smoke outside home	1.0	1.3	1.9	1.3	-1.4	-0.5	-1.1
Comparative body size at age 10	0.4	1.0	1.8	-1.3	0.4	0.7	1.2
Number of full brothers	1.0	1.3	2.7	0.7	0.1	-1.6	-1.4
Worry too long after embarrassment	0.3	0.5	1.2	0.2	-1.1	-0.7	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	4.3	2.1	-1.3	0.1	-2.0
Wheeze or whistling in the chest in last year	3.3	5.8	17.1	-0.8	-2.3	-4.1	0.3
Number of children fathered	0.5	0.5	1.9	-0.2	0.3	-1.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.5	-0.9	1.2	-0.7	0.9
Age at first live birth	1.3	2.4	3.6	-1.4	1.2	1.5	1.9
Pulse wave peak to peak time	1.7	2.1	5.5	-1.1	2.4	0.8	0.9
Health satisfaction	4.5	5.8	12.4	1.4	-3.5	-2.4	-1.7
Shortness of breath walking on level ground	0.9	1.1	3.4	-0.4	-1.9	-0.7	0.5
Qualifications: College or University degree	1.4	4.3	13.0	1.2	-1.1	3.6	-1.2
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.6	0.6	0.2	0.0
Mouth/teeth dental problems: Loose teeth	1.2	1.5	2.2	1.3	-1.5	-0.4	-1.4
Emphysema/chronic bronchitis	1.6	1.8	3.3	0.8	-1.1	-1.8	-1.5
Medication for pain relief, constipation, heartburn	1.2	2.1	7.5	0.5	0.8	2.7	-0.3
Neck or shoulder pain in last month	0.6	0.8	1.0	0.9	-1.0	-0.6	-1.0
Medication: Blood pressure	1.7	3.0	6.6	1.6	-0.4	-2.6	-1.7
Angina (self-reported)	3.2	4.2	4.5	2.0	-2.1	-2.1	-2.0
Migraine (self-reported)	2.1	2.6	4.7	-2.1	1.1	-0.3	2.2
Medication: Ibuprofen	0.6	0.7	1.4	0.5	-0.4	-0.9	-1.2
Medication: Allopurinol	1.0	1.3	2.6	0.9	-1.3	-1.6	-0.4
Medication: Omeprazole	1.2	1.4	4.5	-0.0	2.1	-1.0	0.4
Medication: Seretide 50 evohaler	0.5	0.5	0.8	-0.9	-0.3	-0.9	0.7
Mean time to correctly identify matches	0.4	0.8	2.5	0.2	-0.9	-1.6	0.0
Heart disease (mother)	0.7	0.8	1.2	0.7	-1.0	-0.7	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	3.1	-1.7	1.0	-1.3	1.8
Whole body fat mass	1.5	6.2	14.3	-0.6	-3.8	-3.1	0.7
Leg fat mass (right)	1.4	5.4	11.8	-0.0	-3.4	-3.1	0.0
Arm predicted mass (right)	0.7	3.6	4.3	-2.1	-1.6	-1.9	2.0
Pulse rate, automated reading	1.0	3.2	8.0	-1.1	-2.8	-1.6	1.1
Alcohol intake frequency.	0.1	0.2	0.3	0.2	-0.6	0.5	-0.1
Comparative height size at age 10	1.5	8.4	15.1	-3.3	1.8	2.2	3.9
Number of full sisters	1.5	1.8	5.5	0.6	0.3	-2.4	-1.1
Suffer from ‘nerves’	0.2	0.3	0.6	0.8	0.7	0.2	-0.4
Overall health rating	2.4	5.2	13.8	-0.3	-2.6	-3.7	-0.0
Chest pain or discomfort	3.5	5.1	13.5	1.4	-1.3	-3.7	-1.7
Had major operations	0.4	0.4	0.9	0.2	-1.0	-0.9	-0.1
Age at last live birth	0.9	1.3	2.1	1.0	1.3	1.4	-0.7
Family relationship satisfaction	0.2	0.2	0.5	0.5	-0.2	0.7	-0.3
Leg pain on walking	1.3	1.6	4.2	0.0	-2.0	-1.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	4.2	1.8	-1.5	-1.5	-2.1
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	0.0	-0.8	0.6	0.0
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.3	-0.9	1.4	1.8	1.1
Medication: Aspirin	0.4	0.5	1.0	-0.2	-0.8	-1.0	0.3
Supplements: Vitamin C	0.8	1.0	2.4	1.2	0.0	1.6	-0.2
Knee pain experienced in last month	1.3	2.1	4.1	-2.0	0.1	-1.0	1.8
Hypertension (Self-reported)	1.6	4.3	7.9	1.6	-1.1	-2.8	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	3.0	-0.4	-0.1	-1.7	0.3
Illnesses of father: Heart disease	0.9	1.2	2.5	-1.1	-0.6	0.9	1.6
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.1	-0.6	-0.7	-0.1
Smoking status: Previous	0.8	1.2	2.0	1.4	-0.3	-1.0	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.5	-0.4	0.8	1.9	0.8
Whole body fat-free mass	0.9	4.9	6.9	-2.6	-2.1	-1.4	2.6
Leg fat-free mass (right)	1.2	6.3	8.2	-2.6	-2.9	-1.8	2.6
Arm fat percentage (left)	1.9	7.7	20.9	-0.2	-4.6	-3.1	0.4
Average weekly red wine intake	0.5	0.7	1.6	-0.5	-1.0	1.3	0.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.9	-0.9	1.7	-0.4	0.7
Mood swings	1.6	2.9	5.8	2.4	0.6	0.8	-2.2
Loneliness, isolation	0.9	1.3	2.8	0.3	-1.2	-1.7	-1.0
Long-standing illness, disability or infirmity	2.0	3.1	7.6	1.1	-2.8	-1.3	-1.3
Ever had bowel cancer screening	0.6	0.8	1.5	-0.3	-0.9	1.2	0.7
Diabetes diagnosed by doctor	1.7	2.8	6.2	0.3	-2.5	-2.0	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	3.6	-0.1	-0.9	-1.9	-0.0
Friendships satisfaction	1.1	1.4	2.1	1.5	-1.0	0.8	-1.3
Qualifications: nursing, teaching	1.7	2.7	7.5	0.7	-1.1	2.7	-1.3
Commuting to job workplace: Walk	1.3	1.4	2.6	1.5	0.8	0.3	-1.6
Eye problems/disorders: Cataract	0.2	0.2	0.6	0.2	-0.8	-0.5	0.1
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.3	1.1	-1.5	0.5	-0.2
Medication for cholesterol	0.9	1.3	2.5	1.0	1.2	1.6	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.0	-1.4	0.8	-0.0	1.4
Back pain experienced in last month	0.9	1.3	3.7	0.6	-1.9	0.0	-1.0
Mineral and other dietary supplements	1.4	1.9	4.5	-0.1	-1.8	-2.1	0.2
Breast cancer (self-reported)	1.0	1.2	3.9	-0.5	0.9	2.0	0.4
Asthma (self-reported)	1.2	2.3	3.7	0.7	-1.8	-1.9	-1.4
Osteoporosis (self-reported)	1.6	1.9	6.5	0.4	1.0	2.5	0.1
Osteoarthritis (self-reported)	0.9	1.2	2.5	1.3	-0.1	-0.7	-1.6
Medication: Aspirin	0.2	0.3	0.8	-0.0	-0.4	-0.9	0.2
Medication: Gliclazide	0.8	0.9	1.7	1.3	-0.4	-0.4	-1.2
Illnesses of father: None of the above (group 1)	3.3	4.1	6.8	2.6	1.4	1.6	-2.3
Smoking status: Current	0.8	1.2	3.0	-0.4	-1.2	-1.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.1	-0.9	-1.8	1.0	0.9
Whole body water mass	0.9	4.9	6.8	-2.5	-2.2	-1.3	2.6
Leg predicted mass (right)	1.2	6.2	8.4	-2.6	-2.9	-1.8	2.5
Arm fat mass (left)	1.9	7.8	19.9	-0.8	-4.5	-3.1	1.0
Number of self-reported non-cancer illnesses	6.9	11.9	13.8	3.0	-3.7	-3.5	-3.5
Average weekly champagne plus white wine intake	0.4	0.5	1.4	0.0	-0.8	1.2	-0.2
Miserableness	1.3	2.2	4.1	2.0	0.2	1.2	-1.8
Guilty feelings	0.0	0.0	0.1	-0.2	-0.2	0.2	0.1
Wears glasses or contact lenses	1.4	1.6	5.6	-0.8	-2.4	-0.1	0.6
Ever taken oral contraceptive pill	0.7	0.8	2.2	0.2	-1.5	-0.7	-0.7
Hearing aid user	0.4	0.5	1.0	0.6	-0.4	1.0	-0.6
Mother’s age at death	2.1	2.6	7.4	-0.6	2.7	1.4	0.9
Financial situation satisfaction	1.9	2.4	6.5	1.2	-2.5	-1.2	-0.4
Tinnitus: Yes, now most or all of the time	1.4	1.6	2.6	1.4	-1.6	1.2	-0.7
Commuting to job workplace: Public transport	0.4	0.5	0.8	-0.8	-0.5	-0.3	0.9
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.9	0.8	0.0	1.0
Medication: Blood pressure	0.8	1.5	4.5	0.4	-0.5	-2.1	-1.1
Pain type(s) experienced in last month: Hip pain	1.5	1.9	5.0	0.4	-2.2	-1.3	-0.9
Supplements: Fish oil (including cod liver oil)	2.2	2.9	6.7	0.3	2.6	2.2	-0.4
High cholesterol (Self-reported)	0.7	1.3	2.7	0.3	-1.6	-1.5	-0.5
Medication: Bendroflumethiazide	1.0	1.6	2.5	1.3	0.0	-1.5	-1.6
Medication: Paracetamol	0.5	0.8	1.8	-0.4	-1.4	-1.1	0.1
Medication: Lisinopril	4.7	6.1	11.4	3.2	-1.3	-0.8	-3.4
Medication: Atorvastatin	1.3	1.5	2.3	1.4	-0.7	-1.2	-1.5
Illnesses of father: High blood pressure	2.6	3.3	9.7	-1.0	-1.4	-3.1	0.6
Alcohol drinker status: Never	2.0	2.4	5.2	-1.6	-1.3	0.6	2.3
Ever smoked	0.3	0.5	0.9	-0.4	-1.0	-1.0	0.1
Basal metabolic rate	0.9	5.0	6.5	-2.3	-2.5	-1.7	2.3
Leg fat percentage (left)	1.5	5.3	10.3	0.7	-3.2	-3.2	-0.6
Arm fat-free mass (left)	0.7	3.3	5.4	-1.7	-2.3	-1.5	1.7
Number of operations (self-reported)	0.9	1.3	2.0	0.9	-1.4	-1.2	-1.0
Average weekly beer plus cider intake	1.3	1.9	7.2	-0.3	-0.4	-2.7	-0.4
Irritability	1.4	2.3	5.2	1.8	-0.0	2.3	-0.9
Risk taking	3.2	4.7	8.9	1.8	-3.0	-2.0	-1.8
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.7	-0.8	-2.2	0.4	0.9
Fractured/broken bones in last 5 years	3.0	3.8	8.3	-2.6	0.5	0.5	2.9
Age started oral contraceptive pill	0.2	0.3	0.6	-0.6	0.8	0.5	0.1
Diastolic blood pressure, automated reading	0.5	1.5	2.9	-0.7	-1.6	-1.7	-0.1
Ever depressed for a whole week	0.6	0.8	2.6	0.4	-1.6	-0.6	-0.1
Unable to work because of sickness or disability	0.4	0.5	1.1	-0.1	-1.1	-1.0	0.1
Commuting to job workplace: Cycle	1.4	1.7	3.2	-1.8	0.7	-0.2	1.8
Myopia	1.2	1.8	4.1	1.6	-0.2	2.0	-0.7
Vascular/heart problems diagnosed by doctor	2.6	7.1	10.8	-2.3	1.4	3.3	3.2
Cholesterol lowering medication	0.5	0.7	1.2	-1.0	0.4	-1.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.4	-0.0	1.2	-1.2	0.5
Pain experienced in last month	0.7	1.1	3.8	0.1	0.8	1.9	-0.2
Supplements: Calcium	0.5	0.5	1.0	0.8	0.1	1.0	-0.7
Basal cell carcinoma (self-reported)	0.3	0.3	1.1	0.5	-1.0	0.1	-0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.8	0.7	-0.4	-1.4	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	-1.0	-0.0	-0.3	1.0
Heart disease (siblings)	0.4	0.5	1.3	-0.0	-1.1	-0.8	0.4
Alcohol drinker status: Previous	1.8	2.1	3.7	1.5	-0.9	-1.2	-1.9
Pack years of smoking	1.5	2.2	4.3	-0.5	-2.1	-2.1	-0.0
Impedance of whole body	1.1	5.6	10.4	1.3	3.0	3.2	-1.1
Leg fat mass (left)	1.5	5.9	12.4	-0.1	-3.5	-3.3	0.1
Arm predicted mass (left)	0.8	3.8	4.5	-2.0	-2.1	-1.7	2.0