TWAS hub - BTBD6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0720	0.0320	1.8e-03	0.017	0.011	0.022	0.012	0.036	3.3e-03	1.6e-02	9.2e-04	1.2e-02	2.6e-05
2	GTEx	Adipose Subcutaneous	0.0830	0.0320	1.3e-04	0.054	NA	0.044	NA	0.049	2.9e-05	NA	1.5e-04	NA	7.0e-05
3	GTEx	Artery Aorta	0.1310	0.0440	1.5e-04	0.095	NA	0.052	NA	0.089	6.3e-06	NA	7.4e-04	NA	1.3e-05
4	GTEx	Artery Tibial	0.1926	0.0504	2.4e-10	0.122	NA	0.149	NA	0.133	8.8e-10	NA	9.1e-12	NA	1.5e-10
5	GTEx	Breast Mammary Tissue	0.1090	0.0410	1.8e-04	0.139	NA	0.093	NA	0.122	1.3e-07	NA	1.6e-05	NA	7.9e-07
6	GTEx	Colon Sigmoid	0.1940	0.0760	1.2e-03	0.112	NA	0.012	NA	0.077	8.9e-05	NA	1.2e-01	NA	1.1e-03
7	GTEx	Esophagus Gastroesophageal Junction	0.2020	0.0660	8.5e-05	0.231	NA	0.148	NA	0.201	7.3e-09	NA	5.3e-06	NA	8.3e-08
8	GTEx	Esophagus Muscularis	0.2420	0.0560	2.4e-09	0.173	NA	0.148	NA	0.160	1.0e-10	NA	2.7e-09	NA	6.1e-10
9	GTEx	Heart Left Ventricle	0.1318	0.0503	7.6e-04	0.019	NA	0.068	NA	0.039	3.3e-02	NA	1.7e-04	NA	3.8e-03
10	GTEx	Nerve Tibial	0.0823	0.0390	3.9e-03	0.022	NA	0.005	NA	0.006	1.0e-02	NA	1.3e-01	NA	1.1e-01
11	GTEx	Testis	0.1220	0.0470	8.1e-04	0.066	NA	0.060	NA	0.063	7.2e-04	NA	1.2e-03	NA	9.6e-04
12	GTEx	Thyroid	0.3390	0.0590	1.4e-12	0.210	NA	0.230	NA	0.212	5.1e-16	NA	1.5e-17	NA	4.0e-16
13	METSIM	Adipose	0.1326	0.0472	4.6e-07	0.032	0.052	0.052	0.057	0.043	1.3e-05	2.5e-08	2.5e-08	6.4e-09	4.1e-07
14	YFS	Blood	0.0675	0.0172	0.0e+00	0.066	0.069	0.067	0.068	0.070	9.1e-21	1.2e-21	5.7e-21	2.2e-21	8.5e-22
15	TCGA	Brain Lower Grade Glioma	0.0237	0.0135	5.1e-04	0.031	0.020	0.023	NA	0.024	1.8e-04	2.1e-03	9.7e-04	NA	9.2e-04
16	TCGA	Pancreatic Adenocarcinoma	0.1000	0.0690	2.9e-03	0.006	0.035	0.025	NA	0.028	1.7e-01	1.3e-02	3.1e-02	NA	2.4e-02
17	TCGA	Rectum Adenocarcinoma	0.1660	0.0840	3.3e-04	0.166	0.095	0.084	NA	0.111	1.0e-04	3.1e-03	5.3e-03	NA	1.5e-03
18	TCGA	Stomach Adenocarcinoma	0.0390	0.0250	4.3e-03	0.001	0.034	0.020	NA	0.010	2.4e-01	1.7e-03	1.3e-02	NA	5.5e-02
19	TCGA	Thyroid Carcinoma	0.1450	0.0590	9.6e-13	0.103	0.120	0.125	NA	0.136	3.5e-10	1.0e-11	3.3e-12	NA	3.3e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Blood Platelet Count	18.5	214.6	295.8	4.6	-17.2	-14.8	-16.1	-15.7	-15.7	-14.7	-15.0	-16.8	-15.1	-15.4	4.9	-11.0	-15.7	15.9	15.4	15.6	16.2	14.6
Happiness	8.1	9.9	14.0	0.4	-3.4	-3.3	-3.1	-3.4	-3.6	-3.4	-3.4	-3.5	-3.3	-3.5	1.0	-2.9	-3.2	3.3	3.1	3.6	3.7	2.6
Townsend deprivation index at recruitment	7.9	11.1	15.4	0.9	3.9	3.6	3.2	3.7	3.5	3.7	3.7	3.2	3.7	3.7	0.3	2.7	3.7	-3.7	-3.2	-3.7	-3.2	-3.2
Blood Red Count	5.9	57.5	83.4	0.7	-7.9	-8.3	-7.9	-8.5	-8.6	-8.6	-8.5	-7.2	-8.3	-9.1	0.0	-4.5	-8.6	8.6	6.4	9.1	8.2	6.5
Family relationship satisfaction	5.3	6.5	10.0	0.6	-2.8	-2.6	-3.0	-2.6	-3.2	-2.7	-2.6	-3.0	-2.4	-2.8	0.5	-2.3	-2.6	2.6	2.6	2.9	2.6	1.9
Number of full brothers	5.2	6.5	9.3	-1.2	3.0	2.7	1.5	2.9	2.5	2.9	2.9	2.7	2.7	2.7	-1.3	2.0	2.6	-2.8	-2.6	-2.4	-2.8	-3.1
Frequency of depressed mood in last 2 weeks	4.7	6.6	10.3	1.4	-3.2	-2.5	-2.3	-2.8	-3.1	-2.5	-2.6	-2.7	-3.0	-2.9	-0.1	-2.5	-3.0	2.9	2.4	3.1	2.5	1.8
Friendships satisfaction	4.7	5.9	9.3	0.0	-2.4	-2.5	-2.7	-2.5	-3.0	-2.4	-2.5	-3.0	-2.7	-2.7	0.8	-1.7	-2.5	2.5	2.6	2.8	2.4	2.0
Fractured/broken bones in last 5 years	4.3	5.5	8.1	0.4	2.6	2.5	2.3	2.6	2.9	2.5	2.6	2.6	2.5	2.7	-0.3	2.4	2.6	-2.6	-1.9	-2.7	-2.4	-1.7
Time employed in main current job	4.1	4.7	9.5	-2.3	2.2	2.1	1.6	2.2	2.0	2.1	2.1	2.7	2.1	2.1	-1.0	1.2	2.2	-2.2	-3.1	-2.1	-2.2	-2.9
Blood White Count	3.6	27.0	45.6	1.2	-6.5	-4.8	-5.7	-5.2	-5.1	-4.9	-5.0	-6.5	-5.1	-5.2	3.0	-2.2	-4.9	5.2	6.1	5.2	6.8	6.3
Mouth/teeth dental problems: Loose teeth	3.5	4.1	6.2	-1.6	1.8	2.2	1.8	1.8	2.1	2.2	2.1	2.5	1.8	2.1	-1.6	1.6	2.0	-1.9	-2.5	-2.0	-2.3	-2.4
Tinnitus: Yes, but not now, but have in the past	3.4	3.6	7.8	0.4	-1.7	-1.7	-1.6	-2.0	-1.8	-1.7	-1.8	-2.3	-1.6	-1.8	1.6	-1.7	-1.9	2.0	2.5	1.8	2.8	2.4
Multivitamins +/- minerals	3.1	4.0	7.3	0.9	-2.0	-2.0	-2.1	-1.9	-2.1	-2.0	-2.0	-2.6	-1.5	-2.1	1.4	-1.4	-1.8	1.8	2.7	2.0	2.2	2.6
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.5	5.8	1.4	-2.3	-2.0	-1.3	-1.9	-2.4	-1.9	-1.9	-1.8	-1.8	-2.3	-0.6	0.1	-2.0	2.0	2.0	2.4	1.7	2.0
Mouth/teeth dental problems: Dentures	3.0	5.0	9.7	-1.4	2.6	2.0	2.2	2.3	1.9	2.0	2.1	3.0	2.5	1.9	-1.2	1.6	2.2	-2.3	-2.9	-1.8	-2.6	-3.1
Had major operations	2.9	3.4	5.1	0.7	-1.6	-2.0	-1.5	-1.9	-1.9	-2.0	-2.0	-2.1	-1.6	-2.0	0.7	-2.3	-2.1	2.0	2.0	2.0	1.9	1.9
Financial situation satisfaction	2.9	3.6	6.7	1.6	-1.8	-2.0	-1.8	-1.9	-2.5	-2.0	-2.0	-2.0	-2.0	-2.4	-0.6	-0.4	-2.0	2.0	2.0	2.6	1.7	1.5
Depression (Nagel 2018)	2.8	4.2	6.5	1.3	-2.5	-2.0	-1.8	-2.1	-2.3	-2.2	-2.2	-2.3	-2.3	-2.3	-0.2	-0.8	-2.2	2.3	2.1	2.4	2.2	1.8
Deep venous thrombosis (DVT) (self-reported)	2.7	3.4	5.6	-0.1	-1.8	-1.9	-1.4	-1.8	-1.8	-2.0	-2.0	-2.2	-2.0	-1.9	1.4	-0.1	-1.9	1.9	2.4	1.9	2.4	2.3
Lupus	2.6	3.9	7.1	-1.5	-1.1	-2.1	-1.9	-2.2	-2.7	-2.1	-2.2	-1.9	-2.1	-2.5	-1.0	-1.9	-2.3	2.3	1.3	2.6	1.6	1.6
Hypothyroidism (self reported)	2.6	6.1	13.3	-3.6	3.2	2.3	2.2	2.5	2.2	2.4	2.4	2.3	2.7	2.3	-1.0	1.2	2.5	-2.5	-2.7	-2.3	-2.6	-2.5
Wheeze or whistling in the chest in last year	2.6	4.7	8.8	2.5	-1.9	-2.0	-2.4	-2.2	-1.8	-2.0	-2.0	-2.3	-1.5	-2.0	2.2	-1.3	-2.1	2.1	2.5	2.0	3.0	2.6
Average weekly champagne plus white wine intake	2.5	3.4	5.2	-1.3	1.6	2.2	1.1	2.1	1.7	2.3	2.2	2.0	1.9	1.9	-0.8	1.0	2.0	-2.0	-2.0	-1.6	-2.1	-2.2
Primary Biliary Cirrhosis	2.4	3.4	10.3	-0.8	3.2	1.9	2.2	2.0	1.5	1.9	1.9	2.3	1.8	1.6	-0.2	0.1	1.9	-1.9	-1.5	-1.4	-2.1	-2.1
Current tobacco smoking	2.4	3.9	6.6	-0.1	-2.6	-2.1	-1.8	-2.2	-2.4	-2.2	-2.2	-1.7	-2.2	-2.4	-0.8	-2.1	-2.1	2.2	1.3	2.4	1.8	1.4
Ever had bowel cancer screening	2.4	2.8	4.4	-0.1	1.7	2.0	1.8	1.6	2.1	2.1	2.0	1.9	1.5	2.0	0.9	-0.9	1.6	-1.6	-1.8	-2.0	-1.2	-1.8
Smoking status: Current	2.4	3.8	5.8	-0.5	-2.4	-2.1	-1.8	-2.2	-2.4	-2.1	-2.1	-1.5	-2.1	-2.4	-1.1	-2.2	-2.2	2.2	1.2	2.4	1.6	1.2
Diabetes (father)	2.3	2.9	4.5	0.7	-1.5	-2.1	-1.4	-1.8	-1.6	-2.1	-2.0	-1.9	-1.7	-1.8	0.3	-2.1	-1.7	1.7	1.7	1.5	1.8	1.9
Hypothyroidism/myxoedema (self-reported)	2.3	4.4	7.7	-2.5	2.8	2.1	2.1	2.2	2.1	2.2	2.2	1.8	2.4	2.2	-0.0	0.2	2.2	-2.2	-2.1	-2.2	-2.2	-2.1
Number of full sisters	2.3	2.8	4.3	0.8	1.6	1.8	1.5	1.9	1.7	1.9	1.9	1.5	1.9	1.8	0.8	1.2	2.1	-2.0	-1.8	-1.8	-1.5	-1.8
Blood clot in the leg (DVT)	2.2	2.9	4.5	-0.5	-1.8	-1.8	-1.1	-1.8	-1.6	-1.9	-1.9	-2.0	-2.0	-1.8	0.8	0.2	-1.8	1.8	2.1	1.7	2.1	2.1
Health satisfaction	2.2	2.8	5.5	-0.4	-2.4	-1.7	-1.8	-2.2	-1.7	-1.7	-1.8	-1.4	-2.0	-1.7	-0.7	-1.5	-2.2	2.2	0.9	1.7	1.4	0.9
Mean time to correctly identify matches	2.2	4.2	8.5	0.0	-2.9	-2.1	-1.7	-2.4	-1.8	-2.2	-2.3	-2.1	-2.5	-2.1	0.7	-1.2	-2.3	2.4	1.7	2.0	2.4	2.1
Neuroticism (2016)	2.1	3.0	7.4	2.7	-1.8	-1.6	-1.1	-1.5	-1.5	-1.6	-1.6	-2.3	-1.9	-1.5	0.6	-0.8	-1.5	1.5	2.2	1.3	1.8	2.6
Sensitivity / hurt feelings	2.1	3.5	8.9	-0.4	-1.0	-2.0	-2.0	-2.0	-2.5	-2.0	-2.0	-1.9	-2.0	-2.3	-0.8	-3.0	-1.8	1.9	1.1	2.3	1.6	0.9
Commuting to job workplace: Public transport	2.1	2.5	4.3	1.0	-1.1	-1.8	-1.8	-1.6	-2.1	-1.7	-1.7	-1.6	-1.7	-2.0	-0.1	0.2	-1.7	1.6	1.6	2.1	1.5	1.1
Reaction Time	2.0	3.9	6.0	1.2	-2.5	-2.1	-1.5	-2.2	-1.8	-2.1	-2.1	-2.3	-2.4	-2.0	1.1	-0.4	-2.0	2.1	1.9	1.9	2.5	2.3
Wears glasses or contact lenses	2.0	2.3	3.8	-1.4	1.5	1.3	1.9	1.5	1.3	1.3	1.3	2.0	1.5	1.3	-1.4	-0.6	1.2	-1.4	-1.9	-1.2	-1.9	-1.9
Diastolic blood pressure, automated reading	2.0	6.2	8.9	-0.9	2.2	2.8	2.9	2.6	3.0	2.7	2.7	2.8	2.6	2.8	-0.5	2.0	2.6	-2.6	-2.5	-2.8	-2.4	-2.4
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	4.8	-0.3	2.0	1.3	2.0	1.5	1.3	1.3	1.4	1.9	1.7	1.3	-0.6	0.5	1.4	-1.5	-2.1	-1.3	-1.6	-2.2
Loneliness, isolation	1.9	2.7	9.3	3.0	-2.2	-1.2	-1.3	-1.2	-1.2	-1.3	-1.2	-2.0	-1.5	-1.2	1.2	-1.6	-1.4	1.3	2.1	1.1	1.6	2.0
Medication: Gliclazide	1.8	2.0	4.2	-0.3	-1.8	-1.3	-2.0	-1.7	-1.5	-1.3	-1.4	-1.6	-2.0	-1.4	-0.0	-0.5	-1.5	1.7	1.0	1.5	1.4	0.8
Gout (self-reported)	1.7	2.3	4.5	0.6	1.1	1.5	1.1	1.6	2.0	1.5	1.6	1.4	1.9	1.9	-1.1	2.1	1.6	-1.6	-1.2	-2.0	-1.5	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	4.8	0.1	0.7	1.5	0.6	1.9	1.5	1.6	1.7	1.4	2.2	1.6	-0.2	1.3	1.8	-1.9	-1.0	-1.6	-1.0	-1.0
Tense / ‘highly strung’	1.6	2.6	4.2	1.1	-1.0	-1.6	-1.3	-1.8	-1.3	-1.6	-1.7	-1.7	-1.8	-1.5	1.4	-2.0	-1.8	1.8	1.8	1.4	2.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	11.6	3.4	-1.7	-1.7	-1.7	-1.5	-1.9	-1.7	-1.6	-2.0	-1.6	-1.8	0.2	1.2	-1.5	1.5	2.2	1.9	1.9	2.3
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	2.8	0.2	-1.2	-1.4	-1.1	-1.7	-1.1	-1.5	-1.6	-1.2	-1.6	-1.4	0.6	-0.2	-1.5	1.6	1.0	1.2	1.4	1.3
Medication: Levothyroxine sodium	1.5	2.6	6.1	-2.5	1.9	1.5	1.3	1.6	1.5	1.6	1.6	1.3	2.0	1.7	0.2	-0.7	1.6	-1.6	-1.7	-1.7	-1.4	-1.8
Number of incorrect matches in round	1.5	2.5	5.0	-1.0	-1.0	-1.8	-1.0	-2.0	-2.0	-1.8	-1.9	-1.2	-2.2	-2.0	-0.5	-1.1	-1.9	1.9	0.5	2.1	1.3	0.7
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	3.6	0.7	-1.5	-1.6	-1.2	-1.7	-1.7	-1.6	-1.7	-1.8	-1.9	-1.6	0.2	-1.2	-1.8	1.8	1.7	1.6	1.3	1.4
Qualifications: None of the above	1.5	3.3	5.8	-1.0	1.2	1.8	2.2	1.8	2.0	1.7	1.7	2.2	2.0	1.9	-1.1	1.4	1.7	-1.7	-2.3	-1.9	-2.4	-1.9
HbA1C	1.4	1.5	3.1	-0.7	1.5	1.6	1.1	1.3	0.7	1.7	1.6	0.8	1.3	1.5	0.3	-0.2	1.5	-1.4	-1.8	-0.8	-0.8	-1.3
High blood pressure (mother)	1.4	2.0	3.0	0.7	1.3	1.6	1.7	1.6	1.3	1.6	1.6	1.4	1.7	1.4	-0.6	1.4	1.4	-1.6	-1.1	-1.3	-1.6	-1.4
Financial difficulties in last 2 years	1.4	1.9	4.0	-0.7	1.5	1.1	2.0	1.4	1.4	1.1	1.1	1.3	1.1	1.3	-1.6	2.0	1.3	-1.4	-1.2	-1.4	-1.6	-1.1
Loud music exposure frequency	1.4	1.5	4.2	-1.7	-0.8	-1.3	-0.9	-1.3	-1.4	-1.2	-1.2	-0.4	-1.2	-1.3	-2.0	-1.5	-1.4	1.4	-0.3	1.4	-0.0	-0.4
Schizophrenia (2018)	1.3	2.8	4.4	1.1	1.8	1.8	1.4	2.0	1.6	1.8	1.9	1.8	2.0	1.8	-0.2	0.4	1.9	-2.0	-1.3	-1.8	-2.1	-1.7
Medication: Co-codamol	1.3	1.5	3.4	-1.5	-1.9	-1.3	-1.6	-1.7	-1.1	-1.2	-1.4	-0.7	-1.3	-1.1	-1.2	-0.7	-1.6	1.6	-0.1	1.1	0.3	-0.0
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	5.7	2.4	-0.6	-0.9	-0.3	-1.1	-1.1	-1.1	-1.1	-1.7	-1.3	-1.1	0.9	-0.8	-1.1	1.1	1.5	1.1	1.6	1.5
Breastfed as a baby	1.3	1.6	3.7	0.7	-1.9	-1.2	-1.6	-1.4	-1.2	-1.1	-1.2	-1.1	-1.4	-1.3	0.7	-0.3	-1.3	1.4	1.0	1.3	1.7	1.0
HDL Cholesterol	1.2	2.1	4.1	0.5	2.0	1.8	1.5	1.8	1.6	1.9	1.9	1.9	1.5	1.8	-1.4	1.5	1.8	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	1.2	8.9	14.1	-1.8	-3.8	-3.0	-3.2	-3.4	-2.7	-3.1	-3.2	-3.5	-3.3	-2.8	-0.0	-2.1	-3.0	3.3	2.8	2.7	3.4	3.5
Worrier / anxious feelings	1.2	2.2	4.5	-0.3	-1.4	-1.7	-1.7	-1.4	-2.1	-1.8	-1.7	-1.3	-1.3	-2.0	-1.0	-1.6	-1.4	1.4	0.8	2.1	1.1	0.5
Average weekly beer plus cider intake	1.2	1.8	3.5	0.6	1.9	1.2	1.2	1.5	1.5	1.4	1.4	1.4	1.6	1.5	-0.2	-0.2	1.4	-1.5	-1.4	-1.6	-1.4	-1.2
Depressed Affect (Nagel 2018)	1.1	2.3	6.8	2.6	-2.0	-1.3	-0.7	-1.3	-1.6	-1.5	-1.4	-1.8	-1.4	-1.5	0.5	-1.0	-1.4	1.3	1.6	1.6	1.6	1.7
Alzheimer’s Disease (in father)	1.1	1.2	4.4	-0.4	0.6	1.3	0.6	1.2	1.2	1.3	1.2	1.0	1.1	1.2	-0.5	2.1	1.2	-1.2	-0.7	-1.2	-1.2	-0.7
Hand grip strength (left)	1.1	3.0	4.7	0.1	2.2	1.9	2.2	1.7	2.0	1.9	1.9	1.9	2.0	2.0	-0.4	0.9	1.9	-1.8	-1.2	-2.0	-1.9	-1.4
Nervous feelings	1.1	2.0	3.7	0.8	-1.9	-1.4	-1.0	-1.5	-1.5	-1.6	-1.6	-1.7	-1.7	-1.6	0.5	-0.1	-1.5	1.5	1.2	1.6	1.6	1.3
Birth weight of first child	1.1	2.1	3.8	-0.9	-1.2	-1.8	-2.0	-1.8	-1.1	-1.6	-1.6	-1.2	-1.5	-1.3	-0.5	-1.9	-1.9	1.8	0.6	1.2	1.0	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.8	1.1	-0.5	-1.1	-1.2	-1.1	-1.1	-1.1	-1.1	-1.1	-0.8	-1.2	0.6	-1.9	-1.3	1.2	0.9	1.2	1.3	1.0
Neuroticism (Nagel 2018)	1.0	2.3	4.9	2.2	-1.9	-1.5	-1.1	-1.2	-1.5	-1.7	-1.5	-1.8	-1.2	-1.5	0.7	-1.1	-1.5	1.2	1.8	1.4	1.7	1.7
Medication: Metformin	1.0	1.4	2.9	-0.6	-1.4	-1.2	-1.7	-1.4	-1.6	-1.1	-1.2	-1.0	-1.4	-1.4	-0.0	-0.5	-1.4	1.4	0.3	1.6	0.7	0.1
Neuroticism score	1.0	2.1	3.7	1.8	-1.6	-1.4	-1.1	-1.4	-1.7	-1.5	-1.4	-1.6	-1.3	-1.6	0.2	-1.9	-1.4	1.4	1.3	1.6	1.5	1.2
Medication: Lansoprazole	1.0	1.1	2.2	-0.1	0.1	1.2	0.8	1.3	1.2	1.2	1.3	0.7	1.4	1.3	0.7	1.3	1.5	-1.4	-0.4	-1.3	-0.5	-0.4
Medication: Omeprazole	1.0	1.1	6.2	0.4	-2.5	-1.1	-1.0	-1.3	-0.8	-1.0	-1.1	-0.8	-0.9	-0.8	-0.3	-0.6	-1.3	1.3	0.3	0.7	1.0	0.9
Knee pain experienced in last month	1.0	1.5	9.4	-3.1	0.0	0.5	-0.0	0.1	0.9	0.5	0.3	1.6	0.0	0.7	-2.0	1.7	0.0	-0.1	-1.6	-0.7	-1.4	-1.8
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.1	-0.8	-1.2	-1.3	-1.8	-1.6	-1.6	-1.4	-1.4	-1.2	-1.5	-1.5	-0.9	-0.7	-1.6	1.6	0.7	1.6	0.7	0.6
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.4	-1.6	-1.0	-0.9	-1.1	-1.4	-0.9	-1.0	-1.1	-0.1	-1.2	-1.1	-1.9	-0.6	-1.4	1.4	0.1	1.1	0.4	-0.1
Maternal smoking around birth	0.9	1.3	2.8	0.3	-0.7	-1.2	-1.7	-1.2	-1.5	-1.2	-1.2	-1.2	-0.9	-1.4	0.1	-0.3	-1.4	1.3	1.2	1.5	1.1	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.6	1.6	-1.5	-0.8	-0.8	-1.1	-0.9	-1.0	-1.0	-1.2	-1.3	-1.0	-0.0	0.6	-1.2	1.1	1.4	1.0	1.3	1.1
Chronic bronchitis/emphysema (father)	0.9	1.0	3.2	0.0	1.8	1.0	0.7	1.0	0.6	1.1	1.1	1.3	1.6	0.8	-0.8	-0.4	1.0	-1.0	-1.3	-0.6	-0.8	-1.1
Medication: Ramipril	0.9	1.1	7.5	1.1	0.5	1.0	0.9	0.9	0.9	1.0	1.0	0.2	1.0	0.9	1.4	2.7	1.1	-1.0	0.3	-0.9	-0.1	0.2
Illnesses of siblings	0.9	1.2	3.3	0.0	1.3	1.0	0.8	1.1	1.7	1.1	1.1	0.7	1.3	1.6	-1.0	0.3	1.0	-1.1	-0.5	-1.8	-1.1	-0.2
Heart disease (mother)	0.9	1.1	6.4	2.5	0.0	-0.2	-0.5	-0.3	-0.3	-0.1	-0.2	-1.2	-0.1	-0.2	2.2	-0.4	-0.7	0.4	1.7	0.2	1.3	1.3
Number of self-reported non-cancer illnesses	0.9	1.6	3.0	-0.6	1.3	1.4	1.1	1.2	1.7	1.5	1.4	1.1	1.5	1.6	1.3	1.0	1.3	-1.3	-1.0	-1.7	-0.6	-1.0
Medication: Lisinopril	0.9	1.1	3.1	-1.5	-0.5	-1.2	-1.8	-0.8	-1.4	-1.2	-1.1	-0.8	-0.8	-1.2	-0.9	-1.4	-1.0	0.9	0.0	1.3	0.6	-0.3
Number of operations (self-reported)	0.9	1.3	6.8	-0.6	-0.4	-1.0	-1.1	-1.1	-0.9	-0.9	-1.0	-1.2	-0.7	-0.9	0.8	-2.6	-1.2	1.1	1.5	0.9	1.3	1.2
Body Mass Index (BMI) (2010)	0.8	1.1	10.6	-2.8	0.7	-0.4	0.2	-0.4	0.0	-0.4	-0.4	0.9	-1.0	-0.2	-3.3	0.1	-0.2	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.8	1.7	3.6	0.7	1.9	1.4	0.9	1.6	1.0	1.4	1.5	1.3	1.5	1.3	-0.6	-0.0	1.3	-1.5	-1.0	-1.1	-1.7	-1.6
Smoking Status	0.8	1.9	5.1	-2.2	-0.7	-1.3	-0.9	-1.6	-1.5	-1.3	-1.4	-0.4	-1.1	-1.6	-1.2	-2.3	-1.7	1.7	-0.1	1.6	0.6	-0.2
Average weekly spirits intake	0.8	1.0	6.0	-1.8	0.0	0.5	1.2	0.4	0.3	0.4	0.4	1.1	0.2	0.3	-2.4	0.0	0.2	-0.3	-1.2	-0.3	-1.7	-1.4
Vitamin and mineral supplements	0.8	1.1	1.9	0.0	1.2	1.1	1.1	0.9	1.0	1.2	1.1	1.4	0.8	1.1	-1.2	0.3	0.9	-0.9	-1.2	-0.9	-1.3	-1.3
Stomach or abdominal pain in last month	0.8	0.9	4.8	2.2	0.2	0.8	1.1	0.8	0.7	0.7	0.7	0.1	0.6	0.7	1.8	1.9	0.6	-0.7	0.4	-0.6	0.0	0.3
Waist circumference	0.8	2.9	5.2	1.3	-2.3	-1.5	-1.7	-1.7	-1.4	-1.6	-1.6	-2.1	-1.5	-1.5	1.4	-0.6	-1.8	1.8	1.9	1.4	2.2	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	10.2	3.2	-1.0	-0.8	-0.9	-0.7	-0.8	-0.8	-0.8	-1.7	-1.1	-0.9	1.7	0.0	-0.8	0.8	1.9	0.9	1.7	2.0
Mouth/teeth dental problems	0.8	1.3	3.4	0.9	-1.3	-1.1	-0.9	-1.2	-0.9	-1.1	-1.1	-1.3	-0.9	-0.9	0.0	-1.8	-1.1	1.1	1.2	0.9	1.1	1.5
Pulse rate	0.8	1.3	2.5	-0.7	-1.1	-1.1	-1.6	-1.2	-1.1	-1.2	-1.2	-1.4	-0.7	-1.1	0.4	-1.4	-1.1	1.2	1.2	1.1	1.2	1.1
Length of working week for main job	0.8	0.9	1.5	-0.8	1.1	0.9	1.2	1.1	0.7	1.0	1.0	1.0	0.9	0.9	-0.8	0.3	0.9	-1.0	-0.9	-0.8	-1.2	-0.8
Glaucoma (self-reported)	0.8	1.0	4.3	2.1	1.3	1.1	0.9	0.9	1.1	1.1	1.1	0.7	0.8	1.1	-0.0	0.1	1.0	-0.9	0.0	-1.0	-0.7	0.1
Emphysema/chronic bronchitis	0.8	0.9	2.1	0.9	0.4	1.3	0.9	1.0	0.9	1.2	1.2	0.8	1.1	1.1	0.1	1.5	0.8	-0.9	-0.5	-0.9	-0.8	-0.7
Back pain experienced in last month	0.8	1.2	2.9	-1.2	0.5	0.8	1.0	0.8	0.9	0.8	0.8	1.7	0.9	0.9	-1.1	0.6	0.6	-0.8	-1.6	-0.9	-1.7	-1.7
Osteoporosis (self-reported)	0.8	1.0	2.7	-0.8	1.0	1.0	1.4	1.2	0.5	0.9	1.0	1.1	1.2	0.7	0.0	1.6	1.2	-1.2	-0.8	-0.5	-1.1	-0.8
Alcohol drinker status: Never	0.8	1.0	2.8	0.6	0.5	1.3	0.5	1.3	0.9	1.4	1.3	0.3	1.1	1.2	1.7	-0.3	1.1	-1.2	0.5	-1.0	-0.7	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	4.6	-0.0	-2.2	-1.1	-1.0	-1.2	-0.9	-1.0	-1.1	-0.8	-1.0	-0.9	-0.4	0.0	-1.3	1.2	0.2	0.8	0.9	0.7
Basal cell carcinoma (self-reported)	0.8	0.9	2.7	-0.8	-1.6	-0.9	-0.4	-1.2	-0.8	-0.9	-1.0	-1.0	-0.9	-1.0	-0.2	-0.2	-1.1	1.2	0.9	0.9	1.0	1.0
Ulcerative Colitis (UC)	0.7	1.3	3.1	0.4	0.7	1.5	0.7	1.3	1.8	1.3	1.3	1.4	0.8	1.3	0.2	0.4	1.4	-1.2	-0.7	-1.7	-0.6	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.8	12.6	3.6	0.7	1.4	0.8	1.1	0.9	1.4	1.4	-0.1	0.9	1.2	2.0	0.9	1.2	-1.1	1.0	-1.0	0.1	0.8
Ovarian Cancer	0.7	0.9	2.8	-0.7	0.9	0.6	0.4	1.0	0.5	0.5	0.7	1.2	1.1	0.5	-1.3	0.8	0.9	-1.0	-1.3	-0.5	-1.6	-1.7
Ulcerative Colitis	0.7	1.0	2.0	-0.6	0.6	1.2	0.2	1.1	1.4	1.2	1.2	1.2	0.5	1.1	-0.1	0.6	1.1	-1.1	-0.7	-1.4	-1.0	-1.1
BMI	0.7	4.1	5.9	0.4	-2.4	-2.2	-1.6	-2.4	-1.8	-2.3	-2.4	-2.2	-2.3	-2.0	0.6	-1.6	-2.4	2.4	1.5	1.9	2.2	2.1
Hearing difficulty/problems: Yes	0.7	1.0	2.5	-0.3	-0.6	-1.0	-1.2	-1.1	-1.6	-0.9	-0.9	-0.8	-1.0	-1.3	0.4	-1.6	-1.1	1.2	0.2	1.6	0.9	0.2
Hand grip strength (right)	0.7	2.0	3.7	0.5	1.7	1.6	1.8	1.4	1.5	1.6	1.5	1.4	1.5	1.4	0.2	1.9	1.5	-1.4	-0.9	-1.3	-1.3	-1.1
Hair/balding pattern: Pattern 2	0.7	0.8	2.2	-0.1	0.6	0.9	0.7	0.9	1.4	0.8	0.8	0.9	0.6	1.2	0.0	1.1	1.1	-1.0	-0.5	-1.5	-1.0	-0.3
Weight	0.7	3.4	11.2	3.3	-2.4	-1.5	-1.2	-1.8	-1.5	-1.5	-1.5	-2.0	-1.7	-1.5	1.2	-0.8	-1.8	1.8	1.8	1.6	2.1	2.4
Arm fat-free mass (right)	0.7	3.4	22.9	4.8	-1.6	-1.3	-0.6	-1.7	-1.6	-1.3	-1.3	-1.8	-1.5	-1.5	0.5	-0.8	-1.8	1.7	1.6	1.7	1.8	2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.9	-0.3	-0.9	-1.0	-1.2	-1.0	-0.9	-1.0	-1.0	-1.0	-1.4	-0.9	-0.2	-1.0	-1.0	1.0	0.8	0.9	0.8	0.4
Medication: Ibuprofen	0.7	0.8	2.4	1.5	1.0	1.0	0.4	0.7	1.2	1.0	0.9	1.0	0.6	1.2	0.0	-0.0	0.8	-0.8	-0.6	-1.2	-0.6	-0.6
Arm predicted mass (right)	0.7	3.5	22.2	4.7	-1.8	-1.4	-0.6	-1.8	-1.7	-1.4	-1.4	-1.8	-1.7	-1.6	0.3	-0.7	-1.9	1.9	1.5	1.8	1.7	2.0
Eye problems/disorders: Cataract	0.7	0.8	2.4	-1.1	1.6	0.9	0.9	0.8	1.3	0.9	0.8	0.7	0.5	1.2	0.5	0.4	0.8	-0.8	-0.7	-1.4	-0.7	-0.7
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	-1.4	0.1	1.1	-0.2	0.9	1.1	1.2	1.1	0.7	0.5	1.2	-0.5	1.5	1.1	-0.9	-0.6	-1.2	-0.9	-0.6
LDL Cholesterol	0.6	1.0	1.9	1.0	-1.4	-1.2	-0.6	-1.3	-1.2	-1.2	-1.2	-1.3	-1.2	-1.2	0.5	-1.1	-1.4	0.0	0.0	0.0	0.0	0.0
Angina	0.6	0.8	1.6	1.0	1.0	1.0	0.6	0.7	1.0	0.9	0.9	1.0	1.3	0.9	-0.5	0.3	0.9	-0.8	-1.2	-0.9	-1.1	-0.9
Supplements: Zinc	0.6	0.7	1.8	-0.4	-0.9	-0.9	-1.4	-0.6	-1.1	-0.9	-0.9	-0.9	-0.5	-1.0	-0.1	-0.5	-0.6	0.6	0.9	1.0	1.0	0.7
Taking other prescription medications	0.6	1.0	1.9	-0.0	0.7	1.2	0.9	1.0	1.2	1.3	1.2	0.8	1.4	1.3	0.7	1.0	1.0	-1.0	-0.7	-1.2	-0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	8.7	3.0	-0.5	-0.5	-0.5	-0.4	-0.2	-0.4	-0.4	-1.3	-0.9	-0.3	2.0	-0.3	-0.5	0.5	1.6	0.3	1.4	1.6
Sitting height	0.6	4.1	36.1	6.0	-1.7	-1.0	-0.6	-1.3	-1.4	-1.2	-1.1	-2.0	-1.5	-1.4	1.6	0.6	-1.3	1.3	2.3	1.5	2.0	2.7
Hip circumference	0.6	2.5	6.9	2.6	-2.2	-1.1	-1.0	-1.2	-1.1	-1.1	-1.1	-1.9	-1.2	-1.0	2.1	-0.4	-1.3	1.2	1.9	1.1	2.0	2.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.2	1.4	-1.5	-0.8	-0.7	-0.9	-0.9	-0.7	-0.8	-1.3	-0.9	-0.7	0.5	-0.4	-1.2	1.0	1.3	0.8	1.1	1.0
Illnesses of mother	0.6	0.7	2.2	-1.5	-0.5	-1.1	-0.2	-1.1	-0.8	-1.1	-1.1	-0.1	-0.8	-1.0	-1.0	-0.2	-0.8	0.9	-0.6	0.9	0.7	-0.1
Medication: Paracetamol	0.6	1.0	2.8	1.0	-1.7	-1.1	-1.0	-1.2	-0.8	-1.2	-1.2	-0.8	-1.1	-1.0	-0.1	0.1	-1.1	1.1	1.0	0.9	0.8	1.1
Suffer from ‘nerves’	0.6	0.9	3.4	0.7	-1.8	-0.8	-0.5	-1.1	-1.1	-0.9	-0.9	-1.1	-0.9	-1.0	-0.1	-0.6	-1.1	1.1	0.8	1.0	0.8	0.8
Smoking status: Previous	0.6	0.8	3.5	-1.5	1.9	0.8	0.8	0.5	0.9	0.9	0.8	1.0	0.8	0.8	0.1	-0.3	0.5	-0.5	-1.0	-0.7	-0.8	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.8	1.7	-0.4	-0.6	-0.6	-0.7	-0.3	-0.6	-0.6	-0.9	-0.5	-0.4	0.5	0.3	-0.9	0.8	1.1	0.3	1.0	1.4
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.9	-0.3	-0.9	-0.9	-1.4	-0.8	-0.8	-0.8	-0.8	-0.8	-0.5	-0.8	0.3	-1.4	-0.7	0.8	0.6	0.7	0.9	0.8
Basal metabolic rate	0.6	3.1	19.0	4.4	-1.8	-1.3	-0.7	-1.6	-1.7	-1.3	-1.3	-1.8	-1.4	-1.5	0.5	-0.4	-1.7	1.6	1.6	1.7	1.7	2.1
Arm fat-free mass (left)	0.6	2.9	20.4	4.5	-1.7	-1.2	-0.7	-1.6	-1.6	-1.2	-1.3	-1.6	-1.5	-1.5	0.1	-0.6	-1.6	1.6	1.3	1.6	1.5	1.9
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.3	-1.5	1.3	0.8	0.0	1.1	0.6	0.9	0.9	0.7	0.7	0.7	-0.1	0.1	1.0	-1.1	-0.2	-0.6	-0.8	-0.7
Vascular/heart problems diagnosed by doctor	0.6	1.7	2.6	0.5	-0.9	-1.5	-1.6	-1.2	-1.4	-1.4	-1.3	-1.1	-1.5	-1.5	-0.4	-1.4	-1.3	1.2	1.5	1.4	1.2	1.4
Arm predicted mass (left)	0.6	3.3	21.2	4.6	-1.7	-1.3	-0.8	-1.6	-1.8	-1.3	-1.3	-1.7	-1.5	-1.6	0.1	-0.8	-1.8	1.7	1.5	1.8	1.6	1.9
Breast Cancer	0.5	1.1	2.2	0.0	1.0	1.4	1.2	1.1	1.2	1.5	1.4	0.4	0.8	1.3	0.8	0.7	1.2	-1.1	-1.0	-1.2	-0.5	-0.7
Respiratory disease	0.5	1.2	3.2	-0.9	1.8	1.0	0.7	1.0	1.0	1.0	1.0	1.2	1.8	0.9	-0.4	1.1	0.9	-1.0	-1.2	-0.8	-1.0	-1.1
Lung FVC	0.5	2.5	11.2	-3.3	1.1	1.3	1.5	1.0	1.4	1.4	1.3	1.4	1.1	1.4	-2.0	1.0	1.0	-1.0	-1.7	-1.3	-2.2	-2.0
Leg fat-free mass (left)	0.5	2.7	13.6	3.7	-1.8	-1.3	-0.4	-1.6	-1.6	-1.3	-1.3	-1.8	-1.4	-1.5	0.6	-0.1	-1.6	1.6	1.5	1.6	1.6	2.0
Medication: Atenolol	0.5	0.6	1.7	0.5	0.8	0.7	1.0	0.6	0.8	0.6	0.6	1.1	1.1	0.7	-0.7	0.5	0.6	-0.6	-1.3	-0.7	-0.7	-0.9
Leg predicted mass (left)	0.5	2.7	13.3	3.6	-1.8	-1.3	-0.4	-1.6	-1.6	-1.3	-1.3	-1.8	-1.4	-1.5	0.5	-0.1	-1.6	1.6	1.5	1.6	1.5	2.0
Trunk fat mass	0.5	2.3	5.2	2.3	-2.2	-1.3	-1.3	-1.4	-1.2	-1.2	-1.2	-1.7	-1.2	-1.2	1.6	-0.4	-1.4	1.4	1.5	1.2	1.9	2.0
Trunk fat-free mass	0.5	2.7	23.5	4.8	-1.3	-0.8	-0.2	-1.3	-1.5	-0.9	-0.9	-1.6	-1.1	-1.3	0.1	-0.2	-1.4	1.3	1.6	1.6	1.4	1.9
Alcohol intake versus 10 years previously	0.5	0.7	1.6	-0.1	-1.2	-1.2	-0.4	-0.7	-1.2	-1.3	-1.2	-0.6	-0.6	-1.3	0.0	-0.5	-0.8	0.8	0.3	1.2	0.7	0.4
Father’s age at death	0.5	0.7	7.0	-2.6	-0.3	-0.2	0.5	-0.5	0.3	-0.2	-0.3	0.5	-0.5	0.1	-1.3	-1.2	-0.3	0.4	-0.7	-0.3	-0.7	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.1	1.1	0.7	1.3	0.6	1.2	1.1	1.4	1.4	0.5	0.7	1.4	0.9	1.2	1.2	-1.2	-0.1	-1.4	-1.0	-0.4
Arm fat mass (right)	0.5	1.9	4.4	1.5	-2.1	-1.3	-1.1	-1.5	-1.2	-1.3	-1.3	-1.5	-1.4	-1.2	0.9	-0.7	-1.5	1.5	1.2	1.2	1.6	1.8
Standing height	0.5	5.1	54.2	7.4	-1.3	-0.8	-0.9	-0.8	-1.5	-0.8	-0.7	-2.2	-0.9	-1.2	2.1	0.9	-0.8	0.8	2.8	1.4	2.1	2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.4	1.6	-0.6	-0.6	-0.5	-1.0	-1.1	-0.7	-0.7	-0.8	-0.9	-0.9	-0.6	-0.3	-1.3	1.1	0.5	1.2	0.6	0.2
Pulse wave reflection index	0.5	0.6	1.8	-0.1	0.7	1.0	0.4	1.0	0.7	1.0	1.0	0.7	0.9	0.7	0.1	1.3	1.0	-1.0	-0.4	-0.6	-0.6	-0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	3.0	1.7	0.2	-0.3	-0.8	-0.6	0.2	-0.4	-0.4	-0.7	-0.6	-0.0	1.2	0.3	-0.4	0.5	1.1	-0.2	0.7	1.2
Comparative body size at age 10	0.5	1.3	4.2	-1.9	0.5	1.0	0.6	0.9	0.9	1.0	0.9	1.1	0.9	1.0	-2.0	0.7	1.0	-0.9	-1.1	-1.0	-1.5	-1.1
Worry too long after embarrassment	0.5	0.8	3.5	1.1	-0.0	-0.6	-0.7	-0.3	-1.1	-0.6	-0.5	-1.0	-0.2	-0.9	1.2	-1.9	-0.4	0.3	1.2	1.1	1.0	0.7
Eye problems/disorders: None of the above	0.5	0.6	1.7	-0.8	-0.2	0.7	0.5	0.8	0.1	0.7	0.7	1.0	0.8	0.3	-0.8	0.9	0.8	-0.7	-0.9	-0.1	-0.8	-1.3
Angina (self-reported)	0.5	0.6	1.2	1.0	0.9	0.8	0.5	0.5	0.8	0.7	0.6	0.9	1.1	0.7	-0.5	0.1	0.7	-0.6	-1.0	-0.7	-1.1	-0.8
Medication: Allopurinol	0.5	0.7	3.3	1.8	0.1	0.8	-0.0	0.8	1.0	0.9	0.9	0.3	1.1	1.1	-0.5	0.6	0.7	-0.8	0.1	-1.1	-0.9	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.1	0.1	-1.1	-0.6	-1.5	-0.7	-0.8	-0.4	-0.5	-0.6	-0.6	-0.7	0.3	-0.8	-1.0	0.8	1.0	0.8	0.7	0.5
Commuting to job workplace: Car/motor vehicle	0.5	0.6	4.1	-2.0	-0.5	0.5	0.4	0.2	-0.0	0.3	0.3	0.7	0.4	0.1	-1.5	-0.9	0.2	-0.2	-0.9	0.1	-0.7	-1.0
Leg fat-free mass (right)	0.5	2.7	16.4	4.0	-1.8	-1.1	-0.3	-1.4	-1.4	-1.1	-1.1	-1.8	-1.3	-1.3	1.0	0.1	-1.4	1.4	1.6	1.5	1.6	2.1
Illnesses of father: None of the above (group 1)	0.5	0.6	2.7	-1.6	-0.5	0.6	-0.0	0.6	1.2	0.7	0.7	0.6	0.3	1.1	-0.1	0.6	0.6	-0.6	-0.6	-1.3	-0.6	-0.5
Whole body water mass	0.5	3.1	19.6	4.4	-1.7	-1.2	-0.5	-1.6	-1.7	-1.3	-1.3	-1.8	-1.4	-1.6	0.2	-0.4	-1.7	1.6	1.6	1.8	1.6	2.1
Leg predicted mass (right)	0.5	2.9	16.6	4.1	-1.9	-1.2	-0.4	-1.5	-1.5	-1.2	-1.2	-1.9	-1.3	-1.4	1.0	0.0	-1.5	1.5	1.7	1.6	1.7	2.2
Arm fat mass (left)	0.5	2.2	4.2	1.6	-2.0	-1.4	-1.2	-1.6	-1.3	-1.4	-1.4	-1.7	-1.4	-1.3	1.0	-0.8	-1.6	1.6	1.3	1.3	1.7	1.8
Irritability	0.5	0.8	2.6	1.6	-1.1	-0.6	-0.1	-0.8	-0.9	-0.8	-0.7	-0.9	-0.6	-0.9	1.1	-0.5	-0.6	0.7	1.0	0.9	1.4	1.0
Leg fat mass (left)	0.5	1.8	4.0	1.7	-2.0	-1.2	-1.1	-1.5	-1.0	-1.2	-1.2	-1.4	-1.3	-1.0	1.2	-0.6	-1.5	1.5	1.1	1.0	1.6	1.6
Bipolar Disorder (2018)	0.4	0.6	2.4	0.0	-1.5	-0.3	-0.5	-0.6	-0.6	-0.3	-0.4	-0.7	-1.1	-0.4	1.6	-0.5	-0.5	0.6	0.7	0.6	1.1	0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	3.5	1.9	0.5	1.2	0.6	1.2	0.9	1.2	1.2	0.9	1.0	1.1	0.7	-0.1	1.1	-1.2	-0.5	-1.0	-0.9	-0.9
Worry (Nagel 2018)	0.4	0.9	2.6	0.3	-1.6	-1.0	-1.1	-1.0	-1.0	-1.1	-1.1	-0.8	-0.8	-1.1	-0.7	-0.7	-1.0	1.0	0.6	1.0	0.6	0.5
Severe depression (siblings)	0.4	0.5	1.6	-1.0	0.3	0.5	0.9	0.2	0.3	0.3	0.3	1.0	0.1	0.3	-1.3	0.9	0.1	-0.2	-1.1	-0.2	-0.8	-1.3
Trunk fat percentage	0.4	1.5	3.5	1.3	-1.8	-1.1	-1.3	-1.1	-0.8	-1.0	-1.0	-1.4	-0.9	-0.9	1.9	-0.5	-1.1	1.1	1.2	0.8	1.7	1.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.7	0.8	0.4	-0.8	-0.0	-0.8	-0.3	-0.9	-0.8	-0.5	-0.6	-0.6	-0.1	-1.3	-0.9	0.8	0.5	0.4	0.3	0.7
Alcohol usually taken with meals	0.4	0.7	1.7	-1.3	-0.5	-0.7	-1.0	-0.9	-1.1	-0.6	-0.7	-0.4	-1.3	-0.9	-0.8	-0.0	-0.9	1.0	0.4	1.1	0.3	-0.1
Falls in the last year	0.4	0.5	2.0	1.1	-0.2	0.5	0.4	0.8	0.8	0.5	0.6	0.2	0.9	0.7	1.1	1.4	0.7	-0.8	-0.1	-0.7	-0.2	-0.0
Medication: Cholesterol lowering	0.4	0.7	2.1	-0.9	1.4	1.0	1.0	0.6	0.9	0.9	0.8	0.8	0.6	0.8	0.1	0.3	0.7	-0.7	-1.0	-0.8	-0.3	-0.7
Trunk predicted mass	0.4	2.5	22.9	4.8	-1.2	-0.8	-0.2	-1.2	-1.5	-0.9	-0.9	-1.5	-1.1	-1.3	0.1	-0.1	-1.3	1.3	1.5	1.5	1.3	1.9
Peak expiratory flow (PEF)	0.4	1.0	2.2	1.5	0.8	1.3	1.3	1.0	1.0	1.2	1.2	0.7	0.8	1.0	0.3	1.0	1.0	-1.0	-0.4	-0.8	-0.6	-0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.2	0.9	-1.5	-0.4	-0.3	-0.6	-0.5	-0.4	-0.5	-0.9	-0.8	-0.5	0.8	1.1	-0.4	0.6	0.9	0.5	1.0	1.2
Medication: Amlodipine	0.4	0.5	3.5	-1.3	-0.1	-0.1	0.2	-0.5	-0.6	-0.1	-0.2	0.3	-0.7	-0.4	-1.9	0.8	-0.2	0.4	-1.0	0.5	-0.4	-0.7
High blood pressure (siblings)	0.4	0.5	2.0	0.7	-1.4	-0.4	-0.3	-0.8	-1.0	-0.5	-0.5	-0.5	-1.1	-0.8	0.8	0.6	-0.5	0.8	0.5	1.0	0.4	0.2
Medication: Seretide 50 evohaler	0.4	0.5	5.1	-0.5	0.3	0.4	0.5	0.4	0.5	0.4	0.4	0.4	0.8	0.4	-0.1	2.3	0.5	-0.4	-0.2	-0.4	-0.6	-0.2
Leg fat mass (right)	0.4	1.4	3.1	1.3	-1.8	-1.2	-1.0	-1.4	-1.0	-1.1	-1.2	-1.2	-1.2	-1.0	0.7	-0.7	-1.4	1.4	0.8	1.0	1.4	1.4
Overall health rating	0.4	0.9	1.8	-0.9	-1.1	-1.1	-0.7	-1.2	-1.1	-1.2	-1.2	-0.7	-0.8	-1.2	-0.6	-0.2	-1.3	1.2	0.3	1.2	0.8	0.4
Leg pain on walking	0.4	0.4	2.4	-0.5	-1.5	-0.7	-0.1	-1.0	-0.2	-0.7	-0.8	-0.3	-0.8	-0.4	-0.0	0.4	-0.9	1.0	0.2	0.3	0.4	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	2.3	-0.3	-0.6	-0.4	-0.9	-0.5	-0.1	-0.4	-0.4	-0.8	-0.6	-0.2	1.5	-0.9	-0.4	0.5	0.6	-0.0	0.9	0.8
Illnesses of father: Heart disease	0.4	0.6	2.2	1.1	-0.1	-0.6	-0.2	-0.6	-1.4	-0.7	-0.7	-0.6	-0.2	-1.2	-0.3	-0.2	-0.7	0.7	0.5	1.5	0.3	0.2
Whole body fat-free mass	0.4	2.6	20.1	4.5	-1.5	-1.0	-0.3	-1.3	-1.5	-1.0	-1.0	-1.6	-1.1	-1.3	0.2	-0.1	-1.4	1.4	1.4	1.6	1.4	1.9
Average weekly red wine intake	0.4	0.6	1.1	-0.9	1.0	0.9	1.0	0.5	0.9	0.9	0.8	1.0	0.5	0.8	0.4	0.5	0.6	-0.5	-0.7	-0.8	-0.7	-1.0
Commuting to job workplace: Walk	0.4	0.5	6.5	0.5	0.1	0.4	0.6	0.3	0.2	0.4	0.4	0.6	0.2	0.2	0.3	2.6	0.4	-0.3	-0.4	-0.0	-0.2	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.4	3.2	-0.7	1.8	0.9	0.3	0.7	0.1	0.8	0.8	0.5	0.1	0.4	0.4	-0.5	0.5	-0.6	-0.3	-0.1	-0.5	-0.7
Eye problems/disorders: Glaucoma	0.4	0.5	4.0	2.0	0.3	0.5	0.3	0.1	0.8	0.5	0.4	-0.1	-0.1	0.6	0.4	-0.3	0.4	-0.2	1.0	-0.7	0.1	1.2
Illnesses of father: High blood pressure	0.4	0.6	2.0	1.4	-0.0	-0.6	0.1	-0.6	-0.7	-0.7	-0.6	-1.0	-0.6	-0.7	0.7	-0.1	-0.7	0.6	1.0	0.8	0.6	1.0
Heart disease (siblings)	0.4	0.5	2.2	-0.8	1.4	0.4	0.1	0.5	-0.1	0.4	0.4	0.9	0.3	-0.0	0.3	-0.8	0.2	-0.4	-1.1	0.2	-0.5	-1.5
Intelligence (Savage-Jansen 2018)	0.3	0.9	7.2	2.7	0.4	0.5	-0.3	0.5	-0.0	0.6	0.5	-1.0	0.4	0.3	1.9	0.1	0.4	-0.3	1.3	-0.1	0.8	1.3
Crohns Disease (2012)	0.3	0.5	2.9	0.0	-0.2	-0.7	-1.0	-0.4	-0.9	-0.7	-0.6	-0.5	-0.4	-0.8	-1.4	-1.7	-0.5	0.5	0.1	0.7	-0.1	-0.3
Mean Putamen Volume	0.3	0.3	1.6	1.3	-0.2	0.5	0.3	0.8	0.4	0.6	0.6	0.4	0.6	0.5	-0.1	0.5	0.6	-0.7	-0.2	-0.5	-0.8	-0.4
Fasting Glucose	0.3	0.3	2.5	0.5	-0.3	-0.6	-1.6	-0.2	0.1	-0.7	-0.5	-0.3	0.1	-0.8	0.4	0.3	-0.6	0.4	0.8	-0.0	0.9	0.1
Triglycerides	0.3	0.4	1.5	-1.0	-1.1	-0.7	-1.0	-0.4	-0.6	-0.6	-0.5	-0.9	0.0	-0.5	0.4	-1.2	-0.5	0.0	0.0	0.0	0.0	0.0
Height	0.3	5.9	75.0	8.7	-1.7	-0.6	-1.2	-0.8	-1.7	-0.5	-0.5	-2.0	-1.0	-1.2	2.1	0.4	-0.8	0.8	2.4	1.6	1.7	2.4
Allergy or Eczema	0.3	0.9	3.1	1.8	-0.2	-0.7	-1.4	-0.5	-1.5	-0.6	-0.6	-1.1	-0.3	-1.1	0.3	-0.7	-0.6	0.6	1.2	1.3	1.0	0.7
Relative age of first facial hair	0.3	0.6	1.0	0.4	0.2	0.9	1.0	0.7	1.0	1.0	0.9	0.7	1.0	0.9	0.8	-0.3	0.9	-0.8	-0.6	-0.9	-0.6	-0.7
Ever had hysterectomy (womb removed)	0.3	0.4	0.8	0.7	0.1	-0.7	-0.3	-0.6	-0.2	-0.9	-0.8	-0.2	-0.6	-0.6	0.7	-0.7	-0.7	0.6	0.7	0.4	0.6	0.7
Medication for hormone replacement therapy	0.3	0.3	1.6	-1.3	0.1	0.1	0.4	0.0	0.3	0.1	0.1	0.8	0.6	0.2	-1.0	-0.4	0.1	-0.1	-0.7	-0.3	-0.9	-0.9
Diabetes (mother)	0.3	0.3	1.6	-0.9	-1.3	-0.4	-0.9	-0.3	-0.5	-0.5	-0.5	-0.5	-0.3	-0.6	0.2	0.2	-0.4	0.4	0.2	0.6	0.6	0.2
High blood pressure	0.3	0.7	1.7	-0.9	0.3	0.9	1.0	0.7	0.8	0.9	0.8	0.5	1.1	0.9	0.6	1.3	0.7	-0.7	-1.0	-0.9	-0.7	-1.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.3	1.4	-0.4	-0.6	-1.5	-0.5	-1.4	-0.5	-0.5	-0.9	-0.5	-1.0	-0.3	-1.1	-0.5	0.5	0.7	1.2	0.9	0.4
Supplements: Glucosamine	0.3	0.4	4.2	-2.1	0.2	0.4	0.2	0.4	0.7	0.4	0.3	0.3	0.2	0.5	0.5	0.2	0.3	-0.4	0.2	-0.5	-0.4	-0.1
Body mass index (BMI)	0.3	1.2	3.3	0.0	-1.8	-1.1	-0.6	-1.5	-0.8	-1.1	-1.2	-1.0	-1.3	-1.0	0.3	-1.1	-1.4	1.4	0.4	0.9	1.1	1.0
Hearing difficulty/problems with background noise	0.3	0.4	1.5	0.1	-0.9	-0.4	-1.0	-0.8	-0.7	-0.3	-0.4	-0.5	-0.5	-0.5	0.4	-1.2	-0.8	0.8	0.6	0.7	0.4	0.2
Allergy	0.3	0.7	1.8	-0.7	0.2	0.8	1.2	0.7	1.3	0.7	0.7	1.0	0.3	1.1	-0.2	0.6	0.5	-0.7	-0.7	-1.3	-1.2	-0.6
Pain all over the body in last month	0.3	0.3	1.1	0.8	-0.1	0.1	0.2	-0.2	0.5	-0.1	-0.1	-0.5	-0.1	0.3	1.0	-0.9	0.0	0.1	0.6	-0.5	0.7	1.1
Impedance of arm (right)	0.3	1.2	3.2	-0.5	1.1	0.9	-0.1	1.6	0.9	1.0	1.1	0.5	1.4	1.1	1.1	1.8	1.6	-1.6	0.1	-1.2	-0.5	-0.4
Lung cancer (father)	0.3	0.4	1.0	0.7	-0.5	-0.4	-0.6	-0.7	-0.5	-0.6	-0.6	-0.2	-0.3	-0.6	-0.5	-0.9	-0.8	0.7	0.3	0.7	1.0	0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	0.3	1.2	0.5	0.6	0.6	0.9	0.5	0.5	0.5	1.0	0.7	1.0	0.3	0.7	-0.7	-0.2	-0.9	-0.0	-0.1
Body fat percentage	0.3	1.1	3.0	0.8	-1.7	-1.0	-1.2	-1.0	-0.6	-0.9	-0.9	-1.2	-0.8	-0.7	1.7	-0.5	-0.9	1.0	0.9	0.5	1.5	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.8	0.5	-0.9	-0.3	-0.4	-0.9	-0.6	-0.4	-0.5	-0.1	-0.7	-0.5	-1.3	-0.3	-1.1	1.0	-0.1	0.7	-0.0	-0.0
Number of children fathered	0.3	0.3	3.0	-0.0	-0.1	-0.3	-0.3	-0.2	-0.5	-0.5	-0.4	0.1	0.0	-0.5	-1.2	-1.7	-0.3	0.3	0.1	0.5	-0.5	0.2
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.5	0.5	0.9	0.2	0.8	0.8	0.8	0.8	0.6	0.7	0.7	0.6	0.3	0.8	-0.8	-0.5	-0.6	-0.0	-0.3
Whole body fat mass	0.3	1.3	4.0	2.0	-1.8	-0.8	-0.9	-1.0	-0.7	-0.7	-0.8	-1.3	-0.9	-0.7	1.5	-0.3	-1.0	1.0	1.1	0.6	1.5	1.6
Chest pain or discomfort	0.3	0.4	3.4	1.8	0.2	-0.1	0.2	-0.4	0.2	-0.2	-0.3	-0.2	-0.3	0.0	1.4	-0.7	-0.2	0.3	0.4	-0.2	0.6	0.3
Age at last live birth	0.3	0.4	3.6	-1.9	-1.0	-0.2	-0.2	-0.2	-0.3	-0.2	-0.2	0.4	-0.4	-0.2	-0.8	0.3	0.0	0.1	-0.7	0.2	-0.3	-0.9
Arm fat percentage (left)	0.3	1.1	3.2	-0.0	-1.8	-1.1	-1.0	-1.1	-0.8	-1.0	-1.0	-1.2	-1.0	-0.8	1.1	-0.5	-1.1	1.1	0.9	0.7	1.3	1.3
Mood swings	0.3	0.5	3.0	1.7	-0.9	-0.5	-0.1	-0.5	-0.8	-0.6	-0.6	-0.5	-0.4	-0.8	0.1	0.5	-0.6	0.6	0.4	0.9	0.7	0.4
Mineral and other dietary supplements	0.3	0.4	2.6	1.6	-0.1	-0.5	-0.5	-0.5	-0.6	-0.5	-0.5	-0.6	-0.5	-0.5	-0.4	-0.5	-0.5	0.5	0.3	0.5	0.7	0.4
Miserableness	0.3	0.5	5.4	2.3	-0.7	-0.2	0.4	-0.2	-0.4	-0.3	-0.2	-0.7	-0.4	-0.4	1.0	-0.1	-0.5	0.3	0.9	0.4	0.7	0.7
Ever taken oral contraceptive pill	0.3	0.3	1.0	-0.2	-0.5	-0.4	-1.0	-0.6	-0.1	-0.4	-0.5	-0.8	-0.2	-0.3	0.4	-0.9	-0.5	0.5	0.9	0.2	0.6	1.0
High cholesterol (Self-reported)	0.3	0.6	1.2	-0.3	1.0	0.5	1.0	0.7	1.1	0.5	0.6	0.7	0.5	0.8	1.0	0.5	0.7	-0.8	-1.0	-1.0	-0.1	-0.6
Medication: Paracetamol	0.3	0.4	1.5	0.5	-1.2	-0.6	-0.7	-0.7	-0.5	-0.7	-0.7	-0.2	-0.7	-0.6	-0.6	-0.0	-0.7	0.7	0.4	0.6	0.3	0.4
Age started oral contraceptive pill	0.3	0.4	2.6	-1.6	0.4	0.5	-0.1	0.4	0.1	0.5	0.5	0.3	0.7	0.4	-0.5	-0.2	0.4	-0.4	-0.6	-0.3	-0.7	-0.9
Unable to work because of sickness or disability	0.3	0.4	2.0	-0.9	0.5	0.5	0.7	0.1	0.5	0.4	0.3	0.9	-0.0	0.5	-1.0	0.2	0.1	-0.1	-1.4	-0.5	-0.9	-1.0
Pain experienced in last month	0.3	0.5	1.7	0.9	0.2	-0.3	-0.5	-0.3	-0.5	-0.2	-0.2	-1.1	-0.4	-0.4	1.0	-0.8	-0.1	0.2	1.3	0.5	0.7	1.2
Alcohol drinker status: Previous	0.3	0.3	0.9	-0.1	1.0	0.4	0.3	0.5	0.5	0.5	0.5	0.7	0.7	0.6	0.4	-0.8	0.5	-0.5	-0.8	-0.6	-0.3	-0.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.8	-0.9	-0.3	0.4	-0.6	0.2	0.3	0.6	0.5	0.0	-0.3	0.6	0.5	-0.2	0.3	-0.2	-0.1	-0.5	-0.2	-0.4
Crohns Disease (2017)	0.2	0.3	1.6	-1.3	0.6	0.3	0.2	0.6	0.1	0.1	0.2	0.4	0.6	0.1	-1.0	-0.3	0.6	-0.6	-0.2	-0.2	-1.0	-0.8
Irritable Bowel Disease (IBD)	0.2	0.5	1.0	-0.6	0.3	0.8	0.1	0.9	0.8	0.7	0.7	0.9	0.6	0.6	-0.7	-0.0	1.0	-0.9	-0.4	-0.8	-0.9	-0.9
Prostate Cancer	0.2	0.3	2.2	-0.2	1.5	0.4	0.8	0.3	0.3	0.3	0.3	0.7	0.3	0.2	-0.2	0.2	0.3	-0.3	-0.5	-0.2	-0.2	-0.5
Age at First Birth	0.2	0.2	2.9	-1.7	-0.0	0.1	-0.4	0.2	-0.4	0.3	0.3	0.5	0.1	0.0	-0.9	-0.3	0.1	0.0	0.0	0.0	0.0	0.0
Systolic Blood Pressure	0.2	1.1	5.0	2.2	0.1	1.0	1.6	0.6	1.1	1.0	0.9	0.5	1.0	0.9	2.0	0.3	0.8	-0.7	-0.3	-0.9	0.2	-0.3
Cardiovascular Disease	0.2	0.8	1.9	-0.9	0.4	0.7	0.8	0.9	0.8	0.7	0.7	0.8	0.8	0.8	-0.5	0.8	0.9	-0.9	-1.3	-0.9	-0.9	-1.4
Neuroticism	0.2	0.5	2.8	1.7	-0.7	-0.5	-0.3	-0.3	-0.7	-0.6	-0.5	-0.7	-0.1	-0.6	-0.1	-1.6	-0.5	0.3	0.6	0.6	0.7	0.5
Hair Pigment	0.2	5.2	8.6	-0.1	2.9	2.5	2.4	2.6	2.0	2.5	2.5	2.7	2.3	2.1	-1.5	1.3	2.2	-2.5	-2.4	-1.9	-2.9	-2.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	1.0	-1.0	0.3	0.2	-0.1	0.3	0.7	0.2	0.2	-0.0	0.5	0.6	0.9	-0.1	0.3	-0.3	-0.1	-0.8	-0.1	0.1
Pack years adult smoking proportion	0.2	0.3	0.8	0.8	-0.2	0.9	0.3	0.5	0.6	0.8	0.8	0.2	0.2	0.7	0.1	0.3	0.5	-0.5	0.1	-0.6	0.1	-0.0
Relative age voice broke	0.2	0.3	0.8	-0.9	0.1	0.5	0.8	0.3	0.8	0.5	0.5	0.4	-0.3	0.7	0.4	0.2	0.4	-0.3	-0.5	-0.8	-0.2	-0.5
Age when periods started (menarche)	0.2	0.5	2.8	1.0	0.8	0.5	-0.1	0.5	0.7	0.6	0.6	0.1	0.9	0.7	1.7	-1.2	0.5	-0.5	-0.1	-0.7	0.8	0.2
Qualifications: CSEs or equivalent	0.2	0.3	2.9	-0.4	-0.2	-0.2	-0.1	-0.3	0.1	-0.3	-0.3	-0.0	-0.1	-0.0	-1.7	1.1	-0.2	0.2	-0.1	-0.1	-0.1	0.2
Serious illness, injury or assault to yourself	0.2	0.2	1.5	0.4	-0.4	-0.3	-0.3	-0.4	-0.4	-0.3	-0.3	-0.3	-0.4	-0.4	0.3	-1.2	-0.4	0.4	0.1	0.4	0.5	0.0
Impedance of leg (left)	0.2	0.9	1.8	0.7	1.3	0.7	-0.5	1.2	0.9	0.9	1.0	0.5	1.0	1.0	1.3	1.0	1.3	-1.2	-0.0	-1.1	-0.1	-0.5
Past tobacco smoking	0.2	0.4	2.7	1.6	-1.2	-0.4	-0.3	0.1	-0.3	-0.3	-0.2	-0.8	-0.4	-0.2	0.4	0.7	0.2	-0.1	0.6	0.1	0.5	0.9
Had menopause	0.2	0.3	1.1	-1.1	-0.6	-0.4	-0.6	-0.4	-0.5	-0.4	-0.5	-0.3	-0.3	-0.5	0.5	-0.4	-0.6	0.5	0.4	0.6	0.6	0.2
Had other major operations	0.2	0.2	0.8	0.9	-0.7	-0.1	-0.7	-0.1	-0.3	-0.1	-0.1	-0.4	-0.2	-0.2	0.5	-0.5	-0.3	0.2	0.5	0.3	0.5	0.5
Diabetes (self-reported)	0.2	0.4	1.5	-0.5	-0.3	-0.5	-1.2	-0.7	-0.8	-0.4	-0.5	-0.4	-0.4	-0.6	-0.5	-0.7	-0.8	0.7	0.3	0.8	-0.0	-0.3
Fluid intelligence score	0.2	0.4	2.1	1.1	-0.5	-0.1	-0.1	-0.1	-0.6	-0.0	-0.0	-1.0	0.2	-0.3	1.4	-0.3	-0.1	0.1	1.2	0.5	0.8	0.9
Arm fat percentage (right)	0.2	0.7	2.4	-0.2	-1.6	-0.8	-0.9	-0.8	-0.6	-0.8	-0.8	-0.9	-0.7	-0.6	0.8	-0.3	-0.8	0.8	0.7	0.5	1.0	1.1
Noisy workplace	0.2	0.2	0.7	-0.6	-0.1	0.3	0.8	0.4	0.1	0.2	0.2	0.4	0.9	0.2	-0.8	0.4	0.2	-0.4	-0.6	-0.1	-0.7	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	3.0	1.7	0.1	0.0	-0.3	-0.2	0.4	0.0	0.0	0.2	-0.4	0.3	-0.2	-0.3	-0.1	0.1	0.1	-0.3	0.1	0.2
Prospective memory result	0.2	0.2	1.3	-0.9	-0.6	0.3	0.0	0.1	0.3	0.3	0.2	0.3	0.3	0.3	-1.1	-0.6	0.2	-0.2	-0.5	-0.3	-0.4	-0.2
Hair/balding pattern: Pattern 4	0.2	0.4	2.0	1.3	0.8	-0.2	-0.2	-0.5	-0.2	0.1	-0.1	-0.4	-0.0	0.1	1.4	-1.3	-0.3	0.4	-0.0	-0.1	0.5	0.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	-0.4	-0.6	-0.2	0.3	-0.5	-0.1	-0.3	-0.4	-0.5	-0.4	-0.2	0.9	-0.4	-0.3	0.4	0.4	0.1	0.8	0.6
Birth weight	0.2	0.3	1.1	-1.1	1.0	0.2	0.5	0.2	0.4	0.2	0.2	0.7	0.2	0.2	-1.0	0.3	0.1	-0.2	-1.0	-0.2	-0.5	-0.8
Leg fat percentage (right)	0.2	0.8	1.8	0.1	-1.3	-0.8	-0.9	-1.0	-0.4	-0.8	-0.9	-0.8	-0.8	-0.6	1.1	-0.8	-0.9	1.0	0.5	0.5	1.3	0.9
Exposure to tobacco smoke outside home	0.2	0.3	1.9	-1.1	0.2	0.4	0.2	0.5	0.1	0.4	0.4	0.5	0.6	0.2	-1.4	0.4	0.3	-0.4	-0.3	-0.1	-0.8	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.4	2.0	-1.4	1.2	0.4	0.3	0.7	0.3	0.4	0.5	0.4	0.6	0.4	-0.0	-0.5	0.5	-0.6	-0.7	-0.4	-0.6	-0.8
Neck or shoulder pain in last month	0.2	0.3	2.3	-0.4	-0.9	-0.5	-0.4	-0.1	-0.4	-0.5	-0.4	0.1	0.1	-0.4	-0.1	1.5	-0.3	0.2	-0.3	0.4	-0.3	-0.3
Medication: Aspirin	0.2	0.3	1.5	0.5	0.1	0.7	1.2	0.2	0.6	0.5	0.4	0.4	0.4	0.4	0.3	1.0	0.5	-0.3	-0.4	-0.4	0.0	0.1
Hypertension (Self-reported)	0.2	0.5	1.3	-0.7	0.1	0.7	0.7	0.5	0.7	0.7	0.6	0.3	1.0	0.7	0.7	1.1	0.6	-0.6	-0.8	-0.7	-0.4	-0.9
Illnesses of siblings: Diabetes	0.2	0.2	1.6	-1.3	0.2	0.2	0.1	0.1	0.2	0.1	0.1	0.1	-0.1	0.1	0.8	1.1	0.1	-0.1	-0.1	-0.1	0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	0.7	0.5	-0.4	-0.6	-0.4	-0.6	-0.4	-0.4	-0.4	-0.9	-0.6	0.2	0.4	-0.5	0.4	0.3	0.7	0.5	0.2
Breast cancer (self-reported)	0.2	0.2	0.8	0.9	0.9	0.4	0.0	0.4	-0.0	0.5	0.5	0.1	0.5	0.3	0.7	-0.1	0.2	-0.3	-0.2	-0.1	-0.4	-0.3
Osteoarthritis (self-reported)	0.2	0.2	1.8	-0.2	-0.6	-0.3	-1.3	-0.5	-0.1	-0.4	-0.4	0.1	-0.8	-0.3	0.1	0.1	-0.7	0.5	0.0	0.4	0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	-0.8	-0.9	-0.7	-0.5	-0.7	-0.6	-0.8	-0.7	-0.6	-0.7	-0.7	-0.6	-0.6	-0.5	0.6	0.3	0.6	0.1	0.3
Hearing aid user	0.2	0.3	0.5	-0.3	-0.1	-0.6	-0.7	-0.4	-0.6	-0.7	-0.6	-0.3	-0.4	-0.7	-0.5	-0.3	-0.4	0.4	0.3	0.7	0.4	0.5
Mother’s age at death	0.2	0.2	3.2	1.8	0.1	0.2	0.3	-0.2	-0.1	0.1	0.1	-0.3	-0.4	-0.1	-0.1	0.2	-0.2	0.3	0.5	0.2	0.1	0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	-0.5	0.1	0.7	0.8	0.3	1.0	0.6	0.5	0.3	0.2	0.7	0.9	0.5	0.3	-0.3	0.1	-0.8	-0.3	0.2
Ever smoked	0.2	0.4	2.0	-1.4	-0.2	-0.4	-0.1	-0.8	-0.7	-0.5	-0.6	-0.2	-0.3	-0.7	-0.2	-0.6	-0.9	0.9	0.1	0.9	0.4	-0.1
Leg fat percentage (left)	0.2	0.8	2.2	0.3	-1.5	-0.8	-0.9	-1.0	-0.3	-0.7	-0.8	-0.8	-0.9	-0.5	1.4	-0.6	-0.9	0.9	0.6	0.4	1.4	1.0
Risk taking	0.2	0.3	1.9	-1.4	0.4	0.3	-0.1	0.1	0.3	0.2	0.2	0.7	0.3	0.3	-0.9	0.2	0.1	-0.2	-0.8	-0.3	-1.0	-1.0
Ever depressed for a whole week	0.2	0.2	1.7	1.0	0.3	-0.1	0.7	-0.3	0.1	-0.2	-0.2	-0.2	-0.5	-0.1	-0.3	-1.3	-0.4	0.3	0.2	0.0	-0.0	0.1
Commuting to job workplace: Cycle	0.2	0.3	1.0	-1.0	0.3	-0.4	-0.5	-0.4	-0.2	-0.3	-0.3	-0.0	-0.6	-0.1	-0.9	-0.4	-0.4	0.4	-0.7	-0.0	-0.7	-0.7
Cholesterol lowering medication	0.2	0.2	1.0	-0.1	0.5	0.2	0.6	0.4	0.4	0.2	0.3	0.5	0.6	0.3	1.0	-0.5	0.4	-0.4	-0.8	-0.3	0.0	-0.7
Supplements: Calcium	0.2	0.2	1.9	-1.4	0.1	0.3	0.3	0.4	0.0	0.3	0.3	0.2	0.2	0.2	-0.9	-0.2	0.5	-0.4	-0.0	-0.2	-0.9	-0.2
Pack years of smoking	0.2	0.3	0.8	0.4	-0.1	0.9	0.6	0.5	0.7	0.9	0.8	0.3	0.3	0.8	0.2	0.3	0.5	-0.5	-0.1	-0.7	-0.0	-0.1
Heel T-Score	0.1	1.2	13.5	3.7	-0.6	-0.3	0.1	-0.7	-0.4	-0.4	-0.4	-0.6	-1.1	-0.5	0.9	0.9	-0.7	0.8	0.5	0.6	1.1	0.9
Waist Hip Ratio (WHR)	0.1	0.6	1.9	-0.0	-1.0	-0.7	-1.3	-0.5	-0.5	-0.8	-0.7	-1.2	-0.3	-0.6	0.7	0.5	-0.7	0.6	1.4	0.4	0.8	1.0
Lung FEV1/FVC ratio	0.1	0.3	1.9	0.2	-0.1	0.6	0.4	0.3	0.5	0.5	0.4	-0.4	-0.3	0.5	1.4	-0.7	0.4	-0.3	0.6	-0.5	0.6	0.2
Chronotype (morning person)	0.1	0.2	2.3	-1.5	0.1	-0.3	0.3	-0.3	0.1	-0.2	-0.3	0.0	-0.6	-0.1	0.3	0.8	-0.3	0.3	-0.7	-0.0	-0.1	-0.2
Tanning	0.1	1.0	4.5	-0.9	0.2	-0.9	0.3	-1.4	0.2	-0.8	-0.9	0.6	-0.9	-0.3	-2.1	-1.7	-1.1	1.2	-1.2	-0.0	-0.3	-0.3
Systolic blood pressure, automated reading	0.1	0.4	4.4	1.1	-0.5	0.4	1.0	-0.1	0.3	0.4	0.3	-0.0	0.1	0.3	2.1	0.1	0.1	0.0	0.3	-0.2	0.5	0.2
Impedance of leg (right)	0.1	0.7	2.3	0.1	1.5	0.7	-0.4	1.1	0.8	0.8	0.9	0.5	1.0	0.9	0.8	0.6	1.2	-1.2	-0.2	-1.0	-0.2	-0.7
Fed-up feelings	0.1	0.2	1.5	1.2	-0.9	-0.1	0.4	-0.3	-0.3	-0.3	-0.3	-0.3	-0.4	-0.3	-0.2	-0.5	-0.3	0.3	0.3	0.3	0.4	0.3
Forced vital capacity (FVC)	0.1	0.5	6.9	2.6	-0.3	0.1	0.2	0.0	-0.3	0.1	0.1	-0.7	-0.1	-0.1	-0.3	0.9	0.1	-0.0	0.8	0.3	-0.0	0.6
Heart attack	0.1	0.2	1.0	0.5	0.0	-0.1	1.0	-0.3	0.5	-0.2	-0.2	0.3	-0.2	0.1	-0.3	1.0	-0.2	0.3	-0.5	-0.3	0.0	0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	1.1	1.0	-0.4	0.3	-0.6	0.3	-0.1	0.3	0.3	-0.2	0.3	0.0	0.2	0.3	0.4	-0.3	0.1	0.1	0.7	0.2
Medication: Simvastatin	0.1	0.1	0.9	-0.6	0.3	-0.2	0.4	-0.3	0.1	-0.3	-0.3	0.1	-0.0	-0.1	-0.2	-0.9	-0.3	0.3	-0.5	-0.0	0.2	-0.0
Hair/balding pattern: Pattern 3	0.1	0.2	1.2	-1.1	0.6	0.1	-0.1	0.6	-0.1	0.3	0.3	0.2	0.7	0.0	-0.5	0.3	0.2	-0.4	-0.2	0.1	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	5.9	2.4	-0.1	0.3	0.5	0.3	-0.1	0.3	0.3	-0.6	-0.0	0.1	-0.1	1.0	0.3	-0.3	0.8	0.0	-0.0	0.4
Asthma	0.1	0.3	2.1	0.4	0.7	-0.2	0.1	-0.1	-0.2	-0.2	-0.2	-0.4	0.7	-0.3	1.4	0.6	0.1	0.0	0.3	0.3	0.8	0.5
Depression (self-reported)	0.1	0.2	0.5	0.2	-0.7	-0.1	-0.0	-0.5	-0.4	-0.1	-0.2	-0.4	-0.7	-0.3	-0.2	0.1	-0.5	0.6	0.5	0.5	0.3	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	1.1	1.1	0.1	0.5	0.5	0.4	0.2	0.4	0.4	-0.3	-0.0	0.3	-0.4	0.9	0.4	-0.4	0.2	-0.2	-0.5	-0.2
Pulse wave Arterial Stiffness index	0.1	0.2	0.6	0.4	-0.2	-0.1	-0.8	-0.4	-0.1	-0.2	-0.2	-0.2	-0.5	-0.3	0.7	-0.0	-0.2	0.3	0.2	0.2	0.8	0.4
Impedance of arm (left)	0.1	0.6	2.2	-0.2	0.8	0.4	-0.4	1.1	0.5	0.5	0.6	0.1	0.8	0.6	1.5	1.3	1.0	-1.1	0.4	-0.7	-0.0	-0.1
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.4	-0.4	-0.1	-0.6	0.2	-0.5	-0.1	-0.0	-0.3	0.2	-0.4	-0.1	-0.2	-0.2	-0.0	0.6	0.6	0.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.5	-0.5	-0.1	-0.4	-0.1	-0.1	0.0	-0.0	-0.5	-0.2	0.0	0.3	-0.1	-0.1	0.1	0.4	-0.1	-0.2	0.1
Headache pain in last month	0.1	0.1	0.6	-0.3	-0.8	-0.5	-0.2	-0.2	-0.5	-0.5	-0.4	-0.3	-0.2	-0.4	-0.3	0.1	-0.3	0.2	0.5	0.3	0.0	0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	0.7	-0.5	-0.6	-0.8	-0.2	-0.2	-0.5	-0.4	-0.1	-0.4	-0.3	-0.4	-0.5	-0.2	0.2	0.2	0.2	-0.2	0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	1.6	1.3	-0.9	-0.4	-0.6	-0.5	-0.7	-0.4	-0.4	-1.0	-0.7	-0.6	-0.6	0.6	-0.5	0.5	1.0	0.7	0.1	0.6
Age at first live birth	0.1	0.2	1.2	-1.1	-0.8	-0.1	-0.4	-0.4	-0.2	-0.1	-0.2	-0.1	-0.6	-0.0	-0.7	-0.1	-0.1	0.3	-0.4	-0.0	-0.4	-0.3
Pulse wave peak to peak time	0.1	0.1	0.4	0.1	0.1	-0.0	0.6	0.4	0.0	0.1	0.2	-0.1	0.4	0.2	-0.5	0.0	0.1	-0.3	0.1	-0.1	-0.5	-0.1
Qualifications: College or University degree	0.1	0.3	1.5	0.4	-0.2	-0.1	-0.4	-0.2	-0.4	-0.1	-0.1	-0.8	-0.8	-0.2	1.0	-0.4	-0.3	0.3	1.2	0.2	0.4	0.6
Migraine (self-reported)	0.1	0.1	0.6	0.3	0.3	0.1	0.1	0.1	-0.3	0.1	0.1	0.2	0.0	-0.1	-0.4	0.2	0.1	-0.1	-0.2	0.3	-0.3	-0.7
Pulse rate, automated reading	0.1	0.4	4.5	-2.1	0.3	0.2	0.2	0.0	0.7	0.0	-0.0	0.5	0.2	0.3	0.1	0.2	0.1	-0.1	-0.6	-0.5	-0.3	-0.6
Alcohol intake frequency.	0.1	0.1	1.0	0.2	-0.7	-0.2	-0.5	-0.2	-0.4	-0.2	-0.2	-0.1	-0.0	-0.2	0.2	-1.0	-0.3	0.2	0.1	0.3	0.2	0.1
Comparative height size at age 10	0.1	0.5	8.6	2.9	-0.1	0.1	0.0	0.0	-0.1	0.0	0.1	0.1	0.2	-0.1	-0.9	0.6	-0.1	0.0	0.0	0.1	-0.5	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.8	0.5	0.0	-0.4	-0.1	-0.3	-0.0	-0.4	-0.3	-0.4	-0.3	-0.1	0.9	-0.4	-0.1	0.2	0.1	-0.0	0.3	0.3
Supplements: Vitamin C	0.1	0.1	0.5	-0.7	0.2	0.4	0.7	0.4	0.3	0.2	0.3	0.2	0.2	0.3	0.4	0.0	0.3	-0.3	-0.2	-0.3	-0.4	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.5	0.3	0.4	0.5	-0.1	0.6	0.1	0.6	0.6	-0.1	0.7	0.4	0.5	-0.3	0.4	-0.5	0.3	-0.2	-0.0	-0.1
Long-standing illness, disability or infirmity	0.1	0.1	0.5	-0.6	-0.1	0.3	0.7	-0.0	0.5	0.2	0.1	0.3	-0.1	0.4	0.7	-0.2	-0.0	0.0	-0.0	-0.5	-0.0	-0.2
Diabetes diagnosed by doctor	0.1	0.2	1.6	-1.2	-0.5	-0.2	-0.8	-0.5	-0.4	-0.2	-0.3	-0.1	-0.5	-0.3	-0.5	0.2	-0.5	0.5	-0.1	0.4	-0.2	-0.4
Qualifications: nursing, teaching	0.1	0.2	0.8	0.9	0.7	0.5	0.5	0.4	0.3	0.5	0.5	0.1	0.4	0.4	0.7	-0.6	0.3	-0.3	0.4	-0.4	0.1	0.4
Medication for cholesterol	0.1	0.2	1.1	1.1	0.2	0.2	-0.4	0.1	0.1	0.3	0.2	-0.4	-0.3	0.2	-0.2	0.3	0.1	-0.1	0.7	-0.2	0.1	0.6
Asthma (self-reported)	0.1	0.2	1.0	-0.0	0.7	-0.2	0.1	-0.0	-0.1	-0.1	-0.1	-0.1	0.9	-0.3	1.0	0.6	0.1	-0.0	-0.0	0.3	0.5	0.2
Medication: Aspirin	0.1	0.2	0.9	0.3	0.1	0.5	0.9	-0.0	0.5	0.3	0.2	0.2	0.2	0.3	0.6	0.7	0.2	-0.1	-0.3	-0.3	0.3	0.2
Guilty feelings	0.1	0.2	2.4	0.5	0.5	0.4	0.1	0.2	0.4	0.4	0.3	0.3	0.0	0.4	-0.1	-1.6	0.3	-0.2	-0.2	-0.4	-0.4	-0.2
Medication: Atorvastatin	0.1	0.2	0.7	-0.5	0.1	-0.4	-0.0	-0.3	-0.4	-0.3	-0.3	0.1	-0.2	-0.4	-0.8	0.2	-0.5	0.3	-0.6	0.6	-0.1	-0.5
Myopia	0.1	0.2	1.3	-0.2	0.3	0.4	-0.5	0.5	-0.2	0.3	0.4	0.1	0.1	0.1	0.0	-1.1	0.5	-0.5	-0.2	0.0	-0.1	-0.6
Heart attack/myocardial infarction (self-reported)	0.1	0.2	1.1	0.7	-0.0	-0.2	0.8	-0.4	0.3	-0.3	-0.3	0.1	-0.2	-0.0	-0.1	1.0	-0.3	0.3	-0.3	-0.1	0.2	0.2
Impedance of whole body	0.1	0.7	2.7	0.1	1.2	0.5	-0.5	1.2	0.7	0.6	0.7	0.3	0.9	0.7	1.6	1.1	1.2	-1.2	0.2	-0.9	-0.0	-0.3
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0
Number of treatments/medications taken	0.0	0.1	0.2	-0.3	-0.2	0.3	0.2	-0.1	0.3	0.3	0.2	0.3	0.4	0.3	0.1	0.2	0.0	0.0	-0.4	-0.3	-0.1	-0.4
Average weekly fortified wine intake	0.0	0.0	0.3	-0.5	-0.1	-0.0	-0.1	0.1	0.0	-0.1	-0.0	0.0	-0.2	0.1	-0.1	0.3	0.0	-0.1	0.0	-0.1	-0.2	-0.2
Number of live births	0.0	0.0	0.2	-0.4	-0.2	-0.2	0.1	-0.1	0.1	-0.3	-0.2	0.1	-0.1	-0.1	-0.2	0.2	-0.2	0.1	0.1	0.0	-0.0	0.1
Medication: Blood pressure	0.0	0.1	0.4	-0.4	-0.0	0.1	0.6	-0.1	-0.2	0.1	0.0	-0.2	0.4	-0.1	0.4	0.5	-0.1	0.1	0.1	0.2	0.2	0.1
Medication: Blood pressure	0.0	0.1	0.4	-0.2	-0.1	-0.3	-0.0	-0.0	-0.2	-0.3	-0.2	0.2	0.2	-0.3	0.1	0.2	-0.0	0.0	-0.6	0.3	-0.0	-0.5
Medication: Bendroflumethiazide	0.0	0.1	0.3	-0.5	0.2	0.2	-0.2	0.2	0.2	0.1	0.1	0.4	0.3	0.1	-0.2	-0.1	0.1	-0.1	-0.4	-0.1	0.1	-0.2

Hub : Genes

BTBD6

Models

Trait associations