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chr1:160,452,218-163,053,289

Best TWAS P=1.09e-15 · Best GWAS P=4.69e-13 conditioned to 2.77e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	YFS	Blood	HSPA6	0.26	0.08	bslmm	423	0.18	4.6e-56	7.23	-8.0	1.1e-15	-0.72	0.00	1.00	TRUE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FCGR2B	0.14	0.00	enet	12	0.03	9.2e-05	-3.84	6.0	1.7e-09	-0.18	0.01	0.86	TRUE
12	GTEx	Nerve Tibial	PPOX	0.25	0.07	enet	43	0.15	6.7e-11	-3.93	5.9	3.6e-09	-0.01	0.93	0.01	TRUE
15	METSIM	Adipose	C1orf226	0.12	0.11	lasso	6	0.13	2.2e-19	-4.42	-5.3	1.4e-07	0.04	0.12	0.84	TRUE
9	GTEx	Cells Transformed fibroblasts	HSPA7	0.13	0.02	enet	22	0.07	3.3e-06	2.94	7.7	2.0e-14	0.21	0.27	0.19	FALSE
19	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FCGR2A	0.17	0.08	enet	5	0.16	2.3e-07	7.07	-7.2	5.0e-13	-0.45	0.01	0.97	FALSE
16	YFS	Blood	FCGR2B	0.54	0.21	enet	101	0.38	9.1e-133	6.00	6.8	9.0e-12	0.10	0.84	0.16	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FCGR3A	0.08	0.02	blup	18	0.03	3.0e-02	4.61	-6.5	5.9e-11	-0.25	0.01	0.27	FALSE
7	GTEx	Breast Mammary Tissue (Female)	HSPA7	0.14	0.11	lasso	6	0.14	7.3e-05	6.00	-6.3	2.1e-10	-0.37	0.23	0.24	FALSE
4	GTEx	Adipose Subcutaneous	FCGR2C	0.25	0.16	lasso	5	0.14	4.1e-11	5.95	-6.0	1.7e-09	-0.44	0.61	0.39	FALSE
5	GTEx	Breast Mammary Tissue	HSPA7	0.17	0.08	lasso	4	0.12	7.7e-07	5.95	-5.9	2.8e-09	-0.41	0.59	0.36	FALSE
6	GTEx	Breast Mammary Tissue	FCGR2C	0.15	0.13	lasso	2	0.09	2.1e-05	5.95	-5.9	3.3e-09	-0.43	0.52	0.31	FALSE
14	GTEx	Skin Sun Exposed Lower leg	FCGR2C	0.15	0.11	lasso	5	0.07	3.0e-06	5.37	-5.8	7.3e-09	-0.40	0.76	0.23	FALSE
2	GTEx	Adipose Subcutaneous	B4GALT3	0.21	0.05	enet	23	0.11	1.6e-09	2.40	5.7	9.6e-09	-0.08	0.88	0.02	FALSE
10	GTEx	Esophagus Muscularis	HSPA7	0.19	0.14	lasso	2	0.14	1.0e-08	5.37	-5.7	9.6e-09	-0.43	0.71	0.28	FALSE
8	GTEx	Breast Mammary Tissue (Female)	FCGR2C	0.13	0.02	lasso	3	0.04	2.9e-02	6.00	-5.6	2.0e-08	-0.40	0.08	0.20	FALSE
11	GTEx	Muscle Skeletal	FCGR2C	0.12	0.05	lasso	4	0.04	5.2e-05	5.95	-5.6	2.6e-08	-0.44	0.33	0.20	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	FCGR2B	0.04	0.01	enet	11	0.02	6.9e-03	-3.84	5.6	2.6e-08	-0.12	0.01	0.79	FALSE
13	GTEx	Skin Sun Exposed Lower leg	HSPA7	0.25	0.10	enet	22	0.08	2.7e-07	5.95	-5.5	3.1e-08	-0.53	0.64	0.36	FALSE
3	GTEx	Adipose Subcutaneous	HSPA7	0.32	0.13	lasso	10	0.12	5.0e-10	5.95	-5.3	8.8e-08	-0.41	0.61	0.39	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DUSP12	0.06	0.03	bslmm	494	0.04	2.2e-05	0.38	5.2	1.5e-07	0.07	0.42	0.02	FALSE