Hub : Genes

HSPA6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.300	0.0980	0.00440	-0.010	NA	-0.009	NA	-0.010	9.0e-01	NA	8.2e-01	NA	9.9e-01
2	GTEx	Colon Sigmoid	0.445	0.1050	0.00011	-0.008	NA	-0.008	NA	-0.006	8.7e-01	NA	7.8e-01	NA	6.1e-01
3	YFS	Blood	0.258	0.0417	0.00000	0.084	0.138	0.163	0.179	0.161	4.6e-26	7.6e-43	4.9e-51	4.6e-56	3.0e-50

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.2	2.8	0.1	1.7	-0.8
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	-0.2	0.6	-0.4
Depressed Affect (Nagel 2018)	0.4	0.8	1.8	0.8	0.3	-1.3
Depression (Nagel 2018)	0.1	0.2	0.4	0.7	0.2	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.3	-0.9	1.5	0.3
Neuroticism (Nagel 2018)	0.4	0.9	1.6	1.0	0.2	-1.3
Schizophrenia (2018)	0.1	0.2	0.3	-0.3	-0.6	0.1
Schizophrenia vs Biploar Disorder	3.9	5.2	14.6	-0.8	-3.8	-0.5
Worry (Nagel 2018)	0.7	1.5	2.6	1.6	1.1	-0.9
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	-0.5	0.7	-0.5
Alzheimer’s Disease (in father)	1.7	1.8	4.2	1.1	0.1	-2.0
Alzheimer’s Disease (including proxy)	0.7	1.1	2.6	-0.2	0.8	-1.6
Crohns Disease (2017)	0.6	1.3	3.5	0.6	-1.9	-0.1
Irritable Bowel Disease (IBD)	1.5	3.6	5.9	0.7	-2.1	-2.4
Ulcerative Colitis (UC)	2.5	4.8	11.6	0.6	-1.5	-3.4
Major Depression (MDD)	1.5	1.9	3.5	-0.3	-1.4	-1.9
Reaction Time	0.4	0.8	1.5	1.2	0.8	-0.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.3	-0.8	1.5	-0.1
Breast Cancer	0.2	0.6	1.7	-1.3	-0.0	-0.2
Ovarian Cancer	1.4	1.8	4.3	-0.8	-2.1	0.7
Prostate Cancer	1.1	1.6	2.6	-1.1	1.0	1.6
Age at First Birth	0.5	0.8	1.8	1.3	0.1	0.7
Bipolar Disorder (2011)	2.1	2.0	5.5	-0.3	0.7	-2.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.4	-0.7	-0.0	0.1
Coronary Artery Disease (CAD)	0.5	0.7	1.6	1.3	-0.1	-0.6
Crohns Disease (2012)	0.1	0.2	0.4	0.5	-0.1	0.6
Mean Putamen Volume	0.2	0.2	0.3	0.5	-0.6	-0.4
Fasting Glucose	0.4	0.4	1.2	-1.1	0.3	-0.1
HbA1C	0.7	0.7	1.0	0.9	-1.0	0.6
HDL Cholesterol	0.4	0.6	1.6	0.2	1.3	-0.5
LDL Cholesterol	4.1	6.5	17.1	1.6	0.4	-4.1
Lupus	3.5	5.2	12.7	-3.6	-0.6	1.6
Neuroticism (2016)	0.7	1.0	1.5	1.2	-1.2	-0.3
Primary Biliary Cirrhosis	0.6	0.9	1.5	0.1	1.2	-1.1
Rheumatoid Arthritis	4.1	5.6	15.7	0.6	-0.9	-4.0
Schizophrenia (2014)	0.2	0.5	1.5	-0.2	0.1	1.2
Triglycerides	0.1	0.2	0.6	-0.2	0.2	-0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.9	-0.5	0.9	-0.4
Ulcerative Colitis	2.7	3.9	11.3	0.6	-0.1	-3.4
Blood Eosinophil Count	0.4	3.3	5.2	-2.3	0.7	2.0
Blood Platelet Count	0.2	2.3	6.5	0.3	-2.5	-0.4
Blood Red Count	2.3	21.9	64.3	-0.7	1.0	-8.0
Blood White Count	0.5	3.7	7.7	-0.3	-2.8	1.8
Heel T-Score	0.1	1.2	2.4	0.9	0.7	1.6
BMI	0.2	1.2	2.5	-1.6	0.8	-0.7
Height	0.4	7.3	11.2	-2.9	1.5	3.4
Waist Hip Ratio (WHR)	0.1	0.2	0.5	0.2	0.7	0.5
Systolic Blood Pressure	0.0	0.2	0.3	-0.2	0.4	0.6
Smoking Status	0.1	0.4	0.7	-0.5	-0.3	0.8
Allergy or Eczema	0.4	1.1	1.7	-1.3	-1.1	0.6
Cardiovascular Disease	0.3	0.9	1.8	-0.3	1.4	-1.0
Hypothyroidism (self reported)	0.9	2.0	3.1	-1.8	-1.7	-0.3
Respiratory disease	2.2	5.0	8.2	-1.5	-2.1	-2.9
Type 2 Diabetes (T2D) (2018)	1.3	2.5	4.7	2.2	-1.4	-0.9
Lung FEV1/FVC ratio	1.0	4.9	13.8	0.4	0.9	3.7
Lung FVC	0.2	1.3	2.2	0.2	1.5	-1.2
Neuroticism	0.4	1.0	1.5	1.2	0.6	-1.1
Chronotype (morning person)	0.7	1.5	2.5	1.6	0.9	-1.2
Hair Pigment	0.1	2.0	4.9	-0.3	-1.0	-2.2
Tanning	0.0	0.4	1.1	-1.1	-0.5	0.0
Hand grip strength (left)	0.7	1.9	3.8	-1.3	0.3	1.9
Number of treatments/medications taken	1.3	2.4	4.3	-0.8	-1.5	-2.1
Average weekly spirits intake	0.2	0.3	0.7	0.1	0.2	-0.9
Sensitivity / hurt feelings	0.5	0.8	1.6	-0.7	0.7	1.3
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.2	1.1	0.3	0.3
Hearing difficulty/problems: Yes	0.0	0.0	0.0	-0.1	-0.0	-0.1
Relative age of first facial hair	1.5	3.1	4.4	2.0	0.9	2.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	-0.8	0.0	0.4
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.4	-1.0	-1.2	1.0
Ever had hysterectomy (womb removed)	1.9	2.2	2.9	-1.3	1.7	1.3
Systolic blood pressure, automated reading	0.1	0.3	0.7	-0.8	-0.5	0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	-0.0	0.2	0.6
Angina	0.1	0.2	0.3	-0.6	-0.4	0.3
Medication for hormone replacement therapy	1.9	2.2	3.4	-0.7	-1.6	1.9
Vitamin and mineral supplements	0.2	0.3	0.6	-0.3	0.8	-0.5
Supplements: Zinc	2.9	3.1	5.7	-1.8	-2.4	0.7
Medication: Co-codamol	2.7	3.1	6.1	-1.4	-1.2	-2.5
Medication: Metformin	0.6	0.8	1.6	0.8	-0.4	-1.3
Diabetes (father)	0.7	0.8	1.6	0.5	-1.3	0.7
Diabetes (mother)	0.9	1.1	2.0	1.4	1.0	-0.5
Severe depression (siblings)	0.1	0.1	0.3	-0.5	0.3	-0.1
Pack years adult smoking proportion	0.2	0.4	1.0	-0.3	-0.2	-1.0
Impedance of leg (right)	0.6	3.1	6.4	2.5	-0.6	1.6
Leg fat-free mass (left)	0.4	2.2	5.9	-2.4	0.7	0.4
Trunk fat percentage	0.1	0.2	0.6	-0.8	-0.2	0.0
Hand grip strength (right)	1.6	4.3	7.5	-2.2	0.9	2.7
Townsend deprivation index at recruitment	0.1	0.1	0.3	-0.2	-0.1	-0.5
Current tobacco smoking	0.8	1.3	3.1	-1.8	-0.5	0.7
Average weekly fortified wine intake	0.2	0.3	0.6	-0.3	0.3	0.7
Maternal smoking around birth	0.2	0.4	0.7	0.1	-0.8	-0.6
Fed-up feelings	0.8	1.4	2.0	0.9	1.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	0.6	-0.2	0.6
Relative age voice broke	1.2	1.8	2.7	1.6	1.4	0.9
Taking other prescription medications	1.3	2.0	4.5	-1.1	0.3	-2.1
Age when periods started (menarche)	0.9	2.1	3.0	1.3	-1.2	1.7
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	-1.3	0.0	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.1	0.2	-0.2	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.3	0.2	0.5	0.4
Qualifications: CSEs or equivalent	1.4	1.9	3.7	0.7	-1.2	-1.9
Serious illness, injury or assault to yourself	2.3	2.8	4.3	0.7	2.1	-1.9
High blood pressure	0.1	0.3	0.5	-0.5	-0.7	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.2	-1.1	-0.3	0.8
Multivitamins +/- minerals	0.1	0.1	0.3	-0.1	-0.4	0.5
Stomach or abdominal pain in last month	0.4	0.4	0.8	0.7	0.1	0.9
Supplements: Glucosamine	0.4	0.5	0.8	0.8	-0.9	0.4
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.8	-0.7	-1.7	-0.5
Medication: Atenolol	3.0	3.8	7.9	1.6	-2.8	-0.9
Medication: Levothyroxine sodium	0.9	1.6	3.2	-1.2	-1.8	0.2
Sitting height	0.3	2.2	3.8	-1.9	1.0	1.4
Chronic bronchitis/emphysema (father)	0.4	0.4	0.6	-0.7	-0.6	-0.6
High blood pressure (mother)	0.5	0.7	1.2	-1.1	0.4	-0.9
Body mass index (BMI)	0.3	1.3	3.0	-1.7	-0.1	-0.9
Impedance of leg (left)	0.6	2.9	6.4	2.5	-0.3	1.5
Leg predicted mass (left)	0.4	2.2	6.0	-2.4	0.7	0.4
Trunk fat mass	0.2	0.8	2.4	-1.6	-0.1	0.3
Waist circumference	0.4	1.5	4.5	-2.1	0.0	-0.1
Number of incorrect matches in round	1.9	3.1	7.8	2.8	-1.1	-0.6
Past tobacco smoking	0.3	0.6	0.9	0.4	1.0	-0.8
Alcohol usually taken with meals	0.2	0.3	0.7	-0.8	-0.4	0.4
Nervous feelings	0.3	0.5	0.7	-0.2	-0.8	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.2	0.3	0.6
Hearing difficulty/problems with background noise	0.8	1.3	2.2	1.2	-0.2	-1.5
Hair/balding pattern: Pattern 2	0.7	0.9	2.0	-0.8	-1.4	-0.2
Had menopause	0.2	0.2	0.3	-0.1	-0.6	0.6
Had other major operations	3.3	4.1	5.9	-2.4	-2.3	1.0
Forced vital capacity (FVC)	0.1	0.4	0.5	-0.7	0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.3	-0.5	0.1	-0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	0.8	-0.1	-1.0
Qualifications: None of the above	0.4	0.8	1.4	-0.2	-1.2	-1.1
Financial difficulties in last 2 years	0.7	0.9	2.3	0.4	0.5	-1.5
Mouth/teeth dental problems	1.2	1.9	4.8	0.5	2.2	0.8
Heart attack	0.7	0.9	1.3	-1.2	-1.1	-0.0
Allergy	0.3	0.8	1.8	0.7	0.2	1.3
Pain all over the body in last month	0.5	0.5	1.3	-0.4	1.1	-0.0
Diabetes (self-reported)	1.3	2.0	2.8	1.7	-1.1	-1.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.5	-0.5	-1.1	1.6
Medication: Ramipril	0.1	0.2	0.4	-0.2	-0.3	-0.6
Medication: Simvastatin	0.8	1.1	1.6	-1.1	-0.9	-1.2
Fluid intelligence score	0.4	0.9	2.2	-0.4	1.5	0.6
Illnesses of siblings	2.8	3.9	4.9	2.2	2.2	1.4
Neuroticism score	0.1	0.3	0.5	0.6	0.7	-0.1
Weight	0.4	2.1	6.1	-2.5	0.2	0.2
Impedance of arm (right)	0.2	1.1	1.8	1.4	-1.1	0.6
Arm fat percentage (right)	0.2	0.7	1.2	-1.1	-0.8	-0.6
Trunk fat-free mass	0.6	3.6	9.5	-3.1	0.8	0.9
Hip circumference	0.2	1.0	2.4	-1.6	-0.8	-0.2
Time employed in main current job	1.7	2.0	4.7	-0.6	-1.0	-2.2
Alcohol intake versus 10 years previously	1.5	2.3	3.3	0.7	1.8	-1.8
Father’s age at death	0.9	1.1	2.9	-0.7	0.1	1.7
Worrier / anxious feelings	0.3	0.6	1.7	1.3	0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.3	0.6	-0.4	-1.8
Falls in the last year	0.3	0.4	0.9	-1.0	0.4	0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.5	0.3	-0.6
Number of live births	0.9	1.2	1.4	1.1	-1.0	-1.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	-0.1	0.6	0.3
Pulse rate	0.1	0.2	0.5	0.7	-0.3	0.1
Happiness	0.2	0.2	0.2	0.5	0.4	0.5
Noisy workplace	1.7	2.1	3.8	-0.7	-2.0	-1.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	-0.6	0.9	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.0	0.4	-0.8
Mouth/teeth dental problems: Dentures	1.0	1.6	2.5	-0.7	-1.6	-1.4
Asthma	1.3	2.6	4.5	-0.9	-1.6	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.0	-0.2	-0.8	1.0
Medication: Cholesterol lowering	0.7	1.1	2.1	-0.2	-1.0	-1.5
Depression (self-reported)	0.8	0.9	1.0	1.0	0.9	-1.0
Medication: Lansoprazole	2.7	3.1	6.3	1.7	-0.0	-2.5
Prospective memory result	1.3	1.6	3.3	1.8	-0.5	-1.1
Lung cancer (father)	0.2	0.2	0.3	0.5	-0.6	0.0
Illnesses of mother	0.9	1.1	2.8	0.6	0.2	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.9	0.0	0.7	0.9
Pulse wave Arterial Stiffness index	0.9	1.0	2.4	0.7	-0.4	-1.5
Impedance of arm (left)	0.2	0.9	1.4	0.9	-0.8	1.2
Arm fat mass (right)	0.4	1.5	4.3	-2.1	-0.4	-0.2
Trunk predicted mass	0.6	3.4	9.1	-3.0	0.8	0.8
Standing height	0.4	3.8	6.4	-2.2	0.6	2.5
Length of working week for main job	0.9	0.9	2.1	-0.8	-0.3	-1.4
Exposure to tobacco smoke at home	0.4	0.5	0.6	-0.6	-0.7	-0.7
Breastfed as a baby	2.4	2.9	3.4	-1.8	1.7	-1.6
Tense / ‘highly strung’	0.2	0.3	0.4	0.6	0.5	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.8	0.5	0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	-0.8	0.2	-0.7
Birth weight of first child	2.7	4.9	14.5	-0.2	0.3	3.8
Peak expiratory flow (PEF)	0.2	0.4	0.8	-0.6	-0.2	0.9
Pulse wave reflection index	0.7	0.8	1.7	-0.7	0.5	-1.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.5	-0.0	-0.2
Loud music exposure frequency	2.3	2.5	4.4	-1.7	2.1	-0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	-0.6	-0.0	-0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.6	-0.2	-0.9
Blood clot in the leg (DVT)	4.2	5.5	7.8	2.1	2.1	-2.8
Medication: Paracetamol	0.4	0.6	1.3	0.2	1.1	-0.7
Headache pain in last month	0.7	1.2	2.3	0.4	-1.5	-1.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.1	0.2	0.9	1.1
Glaucoma (self-reported)	1.2	1.4	1.7	-1.2	1.1	1.3
Gout (self-reported)	0.5	0.7	1.4	-0.7	-0.4	1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.2	-1.5	-1.3	-0.4
Medication: Amlodipine	0.2	0.3	0.5	0.7	-0.7	-0.0
Medication: Ventolin 100micrograms inhaler	3.3	4.2	7.7	0.9	-2.8	-2.0
Birth weight	2.2	4.8	9.7	-1.1	-1.9	3.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.2	0.6	0.9	-1.1
High blood pressure (siblings)	1.8	2.5	4.1	-2.0	-1.7	-0.8
Forced vital capacity (FVC), Best measure	0.1	0.4	0.7	-0.8	0.8	0.2
Body fat percentage	0.0	0.1	0.3	-0.6	-0.1	-0.1
Leg fat percentage (right)	0.1	0.2	0.4	-0.5	-0.6	-0.1
Arm fat-free mass (right)	0.5	2.8	5.8	-2.4	1.4	0.7
Exposure to tobacco smoke outside home	1.2	1.5	3.6	1.9	1.0	0.1
Comparative body size at age 10	0.6	1.7	4.0	-0.5	2.0	0.9
Number of full brothers	0.5	0.7	1.0	-0.5	-0.9	-1.0
Worry too long after embarrassment	0.2	0.4	0.6	0.8	-0.2	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.5	1.6	1.1	0.0
Wheeze or whistling in the chest in last year	2.0	3.6	5.0	-1.2	-2.2	-2.1
Number of children fathered	0.1	0.1	0.3	-0.5	-0.3	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.8	1.7	-0.6	-0.5
Age at first live birth	2.0	3.6	7.7	1.2	2.8	1.2
Pulse wave peak to peak time	0.9	1.1	2.1	-0.9	0.5	1.5
Health satisfaction	0.6	0.7	1.0	-0.6	-1.0	-0.9
Shortness of breath walking on level ground	1.2	1.5	3.0	0.9	-0.8	-1.7
Qualifications: College or University degree	1.3	4.0	8.7	0.2	1.8	3.0
Eye problems/disorders: None of the above	0.8	0.9	1.4	1.2	0.4	-1.0
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.9	-2.2	-0.4	-0.6
Emphysema/chronic bronchitis	2.3	2.6	4.0	-1.9	-0.1	-2.0
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	0.3	0.6	0.9
Neck or shoulder pain in last month	0.3	0.4	0.9	1.0	-0.4	-0.4
Medication: Blood pressure	1.8	3.2	7.4	0.3	-2.7	-1.4
Angina (self-reported)	0.3	0.3	0.5	-0.7	-0.6	0.3
Migraine (self-reported)	0.3	0.4	1.1	-1.0	0.0	0.2
Medication: Ibuprofen	0.7	0.8	2.3	-0.3	-1.5	-0.3
Medication: Allopurinol	0.1	0.2	0.5	0.1	0.2	0.7
Medication: Omeprazole	2.2	2.6	5.8	2.4	-1.2	0.7
Medication: Seretide 50 evohaler	2.0	2.3	3.9	-2.0	1.1	-1.4
Mean time to correctly identify matches	0.2	0.3	0.8	0.9	0.1	-0.3
Heart disease (mother)	0.5	0.7	0.9	-1.0	1.0	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	-0.2	-1.1	0.6
Whole body fat mass	0.1	0.6	1.8	-1.3	0.1	0.1
Leg fat mass (right)	0.1	0.4	0.9	-0.9	-0.4	0.3
Arm predicted mass (right)	0.5	2.4	4.6	-2.1	1.5	0.4
Pulse rate, automated reading	0.2	0.8	2.0	-0.6	1.4	0.1
Alcohol intake frequency.	0.7	1.6	3.1	-0.8	1.0	-1.8
Comparative height size at age 10	0.3	1.6	3.3	-1.8	1.1	0.4
Number of full sisters	0.2	0.2	0.4	0.1	0.6	-0.5
Suffer from ‘nerves’	0.2	0.3	0.9	-0.0	0.9	0.0
Overall health rating	0.9	1.9	3.4	-0.2	-1.5	-1.9
Chest pain or discomfort	1.1	1.6	2.8	0.2	1.4	-1.7
Had major operations	0.9	1.0	1.8	-0.9	-1.3	0.7
Age at last live birth	0.6	0.8	1.4	0.5	1.2	0.9
Family relationship satisfaction	0.8	1.0	1.8	0.2	1.3	1.1
Leg pain on walking	0.1	0.1	0.3	0.5	-0.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	0.1	0.3	-1.1
Commuting to job workplace: Car/motor vehicle	0.9	1.1	1.9	1.4	-0.0	-1.2
Illness, injury, bereavement, stress in last 2 years	3.2	3.9	10.3	-1.1	-0.3	3.2
Medication: Aspirin	1.3	1.7	2.7	-1.6	-1.6	-0.4
Supplements: Vitamin C	0.5	0.6	1.5	-0.5	-1.2	-0.3
Knee pain experienced in last month	0.2	0.3	0.5	0.4	-0.7	-0.5
Hypertension (Self-reported)	0.1	0.3	0.6	-0.2	-0.8	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.3	0.4	-1.4	-1.5
Illnesses of father: Heart disease	0.3	0.4	1.0	-1.0	-0.6	0.1
Illnesses of siblings: Diabetes	0.5	0.6	1.2	-0.6	-0.5	-1.1
Smoking status: Previous	0.4	0.6	1.6	0.5	-1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	-0.0	0.5	0.7
Whole body fat-free mass	0.5	2.9	7.2	-2.7	0.9	0.7
Leg fat-free mass (right)	0.4	2.2	5.9	-2.4	0.8	0.3
Arm fat percentage (left)	0.1	0.5	1.1	-1.0	-0.5	-0.4
Average weekly red wine intake	0.9	1.3	2.3	-1.5	-0.3	1.2
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.1	1.4	-1.5	-0.0
Mood swings	1.1	2.0	4.4	0.6	-1.0	-2.1
Loneliness, isolation	0.7	1.0	2.0	1.4	0.9	-0.3
Long-standing illness, disability or infirmity	1.2	1.8	3.7	-1.0	-0.8	-1.9
Ever had bowel cancer screening	1.7	2.0	3.6	-1.4	-1.9	-0.6
Diabetes diagnosed by doctor	1.1	1.8	2.4	1.5	-1.2	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.1	0.9	1.8	-0.9
Friendships satisfaction	1.7	2.1	4.1	1.4	2.0	0.4
Qualifications: nursing, teaching	0.6	0.9	2.2	-0.3	1.5	0.5
Commuting to job workplace: Walk	0.2	0.2	0.7	-0.0	0.0	0.8
Eye problems/disorders: Cataract	1.1	1.2	2.9	-1.7	-0.6	0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.7	1.7	0.7	-0.2
Medication for cholesterol	0.1	0.2	0.3	0.4	-0.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	3.5	-1.9	-0.4	-0.1
Back pain experienced in last month	0.2	0.4	1.1	0.1	0.1	-1.0
Mineral and other dietary supplements	1.9	2.5	3.4	-1.5	1.9	-1.4
Breast cancer (self-reported)	0.3	0.4	0.8	-0.5	0.2	0.9
Asthma (self-reported)	1.6	3.1	5.9	-0.8	-1.7	-2.4
Osteoporosis (self-reported)	0.8	1.0	1.7	-0.6	-1.3	1.0
Osteoarthritis (self-reported)	0.4	0.5	0.8	0.3	-0.8	-0.9
Medication: Aspirin	0.7	1.0	2.1	-0.9	-1.5	-0.1
Medication: Gliclazide	0.7	0.8	1.7	1.3	0.7	-0.3
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	1.1	0.8	-0.5
Smoking status: Current	0.6	1.0	2.0	-1.4	-0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.5	0.7	0.7	0.5
Whole body water mass	0.5	3.0	7.7	-2.8	1.0	0.6
Leg predicted mass (right)	0.4	2.4	6.3	-2.5	0.9	0.3
Arm fat mass (left)	0.3	1.1	3.1	-1.8	-0.1	-0.3
Number of self-reported non-cancer illnesses	0.6	1.0	1.3	-1.2	-1.0	-0.7
Average weekly champagne plus white wine intake	0.3	0.5	1.4	1.2	-0.2	-0.1
Miserableness	0.9	1.6	2.6	1.6	1.3	-0.8
Guilty feelings	0.2	0.3	0.5	0.7	-0.6	0.4
Wears glasses or contact lenses	2.9	3.4	5.8	-2.4	-1.8	1.1
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.5	-0.0	0.1
Hearing aid user	0.1	0.1	0.3	0.6	-0.3	0.0
Mother’s age at death	0.6	0.7	1.2	1.1	-0.4	0.9
Financial situation satisfaction	2.0	2.4	3.3	-1.7	-1.8	-1.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.7	-0.7	-1.3	0.5
Commuting to job workplace: Public transport	0.0	0.0	0.1	0.3	0.0	0.1
Eye problems/disorders: Glaucoma	0.5	0.5	0.8	-0.9	0.6	0.7
Medication: Blood pressure	0.2	0.4	0.9	0.1	1.0	-0.6
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.2	1.4	-0.0	1.5
Supplements: Fish oil (including cod liver oil)	2.0	2.6	3.6	1.7	-1.1	1.9
High cholesterol (Self-reported)	1.0	1.7	2.6	-1.6	0.5	-1.5
Medication: Bendroflumethiazide	1.0	1.5	3.7	-1.9	-0.7	0.4
Medication: Paracetamol	0.1	0.2	0.4	-0.4	0.3	-0.6
Medication: Lisinopril	0.6	0.8	1.1	-0.7	-1.0	-0.9
Medication: Atorvastatin	0.5	0.6	1.6	0.5	-0.2	-1.3
Illnesses of father: High blood pressure	0.7	0.9	1.8	-0.8	-0.5	1.3
Alcohol drinker status: Never	0.8	1.0	2.8	-1.7	0.0	-0.4
Ever smoked	0.6	1.1	1.6	-1.1	-0.7	1.3
Basal metabolic rate	0.5	2.7	7.2	-2.7	0.8	0.6
Leg fat percentage (left)	0.0	0.1	0.4	-0.6	-0.2	0.0
Arm fat-free mass (left)	0.4	2.1	4.9	-2.2	1.1	0.2
Number of operations (self-reported)	3.5	5.3	7.9	-1.6	-2.3	2.8
Average weekly beer plus cider intake	2.8	4.0	7.2	2.7	2.0	-0.8
Irritability	0.0	0.0	0.0	-0.2	-0.1	0.2
Risk taking	0.7	1.0	1.8	1.4	0.8	0.8
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.3	0.8	-1.1	0.2
Fractured/broken bones in last 5 years	0.5	0.6	1.5	-0.4	-1.2	-0.2
Age started oral contraceptive pill	0.1	0.1	0.3	0.3	-0.1	0.6
Diastolic blood pressure, automated reading	0.3	1.0	2.0	-1.1	-0.1	-1.4
Ever depressed for a whole week	0.2	0.2	0.3	-0.6	-0.0	0.5
Unable to work because of sickness or disability	2.8	3.7	6.3	-2.5	2.0	-0.9
Commuting to job workplace: Cycle	3.5	4.3	12.1	-3.5	0.5	0.6
Myopia	0.4	0.6	1.6	-1.2	-0.4	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	0.4	0.6	0.0
Cholesterol lowering medication	1.0	1.5	2.4	-1.6	0.5	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	3.1	1.8	-0.7	0.7
Pain experienced in last month	0.0	0.0	0.1	-0.1	-0.0	-0.3
Supplements: Calcium	1.1	1.2	1.8	-1.3	-0.8	1.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	-0.4	-0.4	1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.2	-1.1	-1.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	3.7	4.7	5.7	2.4	1.9	-2.2
Heart disease (siblings)	0.1	0.1	0.1	-0.4	0.2	-0.4
Alcohol drinker status: Previous	1.8	2.1	3.7	1.2	1.9	-1.1
Pack years of smoking	0.2	0.3	0.9	-0.3	-0.2	-0.9
Impedance of whole body	0.4	1.8	4.0	2.0	-0.2	1.2
Leg fat mass (left)	0.1	0.4	1.1	-1.0	-0.1	0.4
Arm predicted mass (left)	0.5	2.5	6.1	-2.5	1.1	0.3