Best TWAS P=1.95e-13 · Best GWAS P=7.38e-21 conditioned to 1.73e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DARS2 | 0.24 | 0.19 | lasso | 7 | 0.18 | 1.6e-21 | -6.0 | 6.1 | 1.0e-09 | 0.04 | 0.55 | 0.45 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RABGAP1L | 0.10 | 0.09 | blup | 647 | 0.11 | 4.0e-13 | -4.8 | -5.9 | 3.0e-09 | -0.02 | 0.71 | 0.28 | FALSE |
| 3 | GTEx | Adrenal Gland | RABGAP1L | 0.18 | 0.02 | lasso | 11 | 0.08 | 6.5e-04 | -5.1 | -5.1 | 2.8e-07 | 0.03 | 0.09 | 0.59 | FALSE |
| 4 | GTEx | Artery Tibial | DARS2 | 0.06 | 0.02 | enet | 14 | 0.01 | 3.3e-02 | -6.9 | 5.2 | 2.5e-07 | -0.01 | 0.02 | 0.91 | FALSE |
| 5 | GTEx | Artery Tibial | PIGC | 0.11 | 0.00 | enet | 21 | 0.01 | 8.4e-02 | 2.7 | -5.3 | 1.1e-07 | 0.40 | 0.06 | 0.10 | TRUE |
| 6 | GTEx | Brain Caudate basal ganglia | DARS2 | 0.19 | 0.02 | lasso | 5 | 0.13 | 1.2e-04 | -6.1 | 6.7 | 2.0e-11 | 0.02 | 0.04 | 0.81 | FALSE |
| 7 | GTEx | Brain Putamen basal ganglia | DARS2 | 0.13 | 0.01 | enet | 14 | 0.00 | 3.7e-01 | -5.6 | 6.6 | 4.5e-11 | 0.03 | 0.06 | 0.67 | FALSE |
| 8 | GTEx | Esophagus Muscularis | DARS2 | 0.11 | 0.12 | lasso | 5 | 0.12 | 1.8e-07 | -6.2 | 5.9 | 2.9e-09 | 0.03 | 0.10 | 0.90 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | DARS2 | 0.10 | 0.09 | lasso | 4 | 0.09 | 5.7e-05 | -6.2 | 6.2 | 7.8e-10 | 0.04 | 0.04 | 0.93 | FALSE |
| 10 | GTEx | Heart Left Ventricle | DARS2 | 0.19 | 0.14 | lasso | 7 | 0.15 | 1.8e-08 | -6.1 | 5.6 | 1.8e-08 | 0.03 | 0.29 | 0.71 | FALSE |
| 11 | GTEx | Muscle Skeletal | DARS2 | 0.11 | 0.11 | lasso | 5 | 0.12 | 7.1e-12 | -6.2 | 6.2 | 4.0e-10 | 0.03 | 0.26 | 0.74 | FALSE |
| 12 | METSIM | Adipose | RABGAP1L | 0.06 | 0.05 | blup | 664 | 0.05 | 1.2e-07 | -4.8 | -5.6 | 2.4e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 13 | NTR | Blood | ZBTB37 | 0.01 | 0.00 | blup | 268 | 0.01 | 4.6e-03 | -4.8 | -5.2 | 2.0e-07 | -0.01 | 0.20 | 0.29 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | SERPINC1 | 0.10 | 0.06 | blup | 47 | 0.06 | 1.8e-04 | -4.0 | -5.9 | 3.9e-09 | -0.01 | 0.02 | 0.85 | FALSE |
| 15 | The Cancer Genome Atlas | Esophageal Carcinoma | MRPS14 | 0.12 | -0.01 | blup | 38 | 0.00 | 3.6e-01 | 5.1 | -5.2 | 2.4e-07 | -0.02 | 0.00 | 0.44 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MRPS14 | 0.06 | 0.01 | blup | 38 | 0.02 | 9.1e-04 | -2.7 | -5.7 | 1.5e-08 | -0.04 | 0.00 | 0.83 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DARS2 | 0.24 | 0.11 | lasso | 2 | 0.12 | 2.1e-13 | -6.0 | 6.0 | 1.4e-09 | 0.04 | 0.51 | 0.49 | FALSE |
| 18 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RABGAP1L | 0.12 | 0.03 | blup | 305 | 0.03 | 1.2e-02 | -5.7 | -5.5 | 3.4e-08 | -0.02 | 0.02 | 0.91 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RABGAP1L | 0.12 | 0.01 | lasso | 6 | 0.03 | 5.0e-04 | -5.6 | -5.9 | 3.5e-09 | -0.02 | 0.03 | 0.97 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZBTB37 | 0.03 | 0.01 | enet | 5 | 0.01 | 1.4e-02 | -6.9 | -6.2 | 4.3e-10 | 0.00 | 0.01 | 0.77 | FALSE |
| 21 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C1orf105 | 0.13 | -0.01 | blup | 100 | 0.03 | 1.5e-02 | 5.2 | 5.2 | 1.8e-07 | -0.23 | 0.02 | 0.58 | TRUE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZBTB37 | 0.04 | 0.02 | blup | 46 | 0.02 | 7.8e-03 | -6.9 | -7.3 | 2.0e-13 | -0.03 | 0.00 | 0.84 | TRUE |