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chr1:171,640,888-175,663,031

Best TWAS P=1.95e-13 · Best GWAS P=7.38e-21 conditioned to 1.73e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZBTB37	0.04	0.02	blup	46	0.02	7.8e-03	-6.9	-7.3	2.0e-13	-0.03	0.00	0.84	TRUE
5	GTEx	Artery Tibial	PIGC	0.11	0.00	enet	21	0.01	8.4e-02	2.7	-5.3	1.1e-07	0.40	0.06	0.10	TRUE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C1orf105	0.13	-0.01	blup	100	0.03	1.5e-02	5.2	5.2	1.8e-07	-0.23	0.02	0.58	TRUE
6	GTEx	Brain Caudate basal ganglia	DARS2	0.19	0.02	lasso	5	0.13	1.2e-04	-6.1	6.7	2.0e-11	0.02	0.04	0.81	FALSE
7	GTEx	Brain Putamen basal ganglia	DARS2	0.13	0.01	enet	14	0.00	3.7e-01	-5.6	6.6	4.5e-11	0.03	0.06	0.67	FALSE
11	GTEx	Muscle Skeletal	DARS2	0.11	0.11	lasso	5	0.12	7.1e-12	-6.2	6.2	4.0e-10	0.03	0.26	0.74	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZBTB37	0.03	0.01	enet	5	0.01	1.4e-02	-6.9	-6.2	4.3e-10	0.00	0.01	0.77	FALSE
9	GTEx	Heart Atrial Appendage	DARS2	0.10	0.09	lasso	4	0.09	5.7e-05	-6.2	6.2	7.8e-10	0.04	0.04	0.93	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DARS2	0.24	0.19	lasso	7	0.18	1.6e-21	-6.0	6.1	1.0e-09	0.04	0.55	0.45	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	DARS2	0.24	0.11	lasso	2	0.12	2.1e-13	-6.0	6.0	1.4e-09	0.04	0.51	0.49	FALSE
8	GTEx	Esophagus Muscularis	DARS2	0.11	0.12	lasso	5	0.12	1.8e-07	-6.2	5.9	2.9e-09	0.03	0.10	0.90	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RABGAP1L	0.10	0.09	blup	647	0.11	4.0e-13	-4.8	-5.9	3.0e-09	-0.02	0.71	0.28	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RABGAP1L	0.12	0.01	lasso	6	0.03	5.0e-04	-5.6	-5.9	3.5e-09	-0.02	0.03	0.97	FALSE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	SERPINC1	0.10	0.06	blup	47	0.06	1.8e-04	-4.0	-5.9	3.9e-09	-0.01	0.02	0.85	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MRPS14	0.06	0.01	blup	38	0.02	9.1e-04	-2.7	-5.7	1.5e-08	-0.04	0.00	0.83	FALSE
10	GTEx	Heart Left Ventricle	DARS2	0.19	0.14	lasso	7	0.15	1.8e-08	-6.1	5.6	1.8e-08	0.03	0.29	0.71	FALSE
12	METSIM	Adipose	RABGAP1L	0.06	0.05	blup	664	0.05	1.2e-07	-4.8	-5.6	2.4e-08	-0.03	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RABGAP1L	0.12	0.03	blup	305	0.03	1.2e-02	-5.7	-5.5	3.4e-08	-0.02	0.02	0.91	FALSE
13	NTR	Blood	ZBTB37	0.01	0.00	blup	268	0.01	4.6e-03	-4.8	-5.2	2.0e-07	-0.01	0.20	0.29	FALSE
15	The Cancer Genome Atlas	Esophageal Carcinoma	MRPS14	0.12	-0.01	blup	38	0.00	3.6e-01	5.1	-5.2	2.4e-07	-0.02	0.00	0.44	FALSE
4	GTEx	Artery Tibial	DARS2	0.06	0.02	enet	14	0.01	3.3e-02	-6.9	5.2	2.5e-07	-0.01	0.02	0.91	FALSE
3	GTEx	Adrenal Gland	RABGAP1L	0.18	0.02	lasso	11	0.08	6.5e-04	-5.1	-5.1	2.8e-07	0.03	0.09	0.59	FALSE