TWAS hub - C1orf226

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.115	0.0276	9.2e-12	0.107	0.073	0.119	0.117	0.133	9.4e-16	4.8e-11	2.1e-17	4.7e-17	2.2e-19
2	TCGA	Colon Adenocarcinoma	0.105	0.0460	4.5e-03	0.060	0.032	0.030	NA	0.034	2.4e-04	5.7e-03	7.0e-03	NA	4.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Number of full brothers	4.2	5.3	10.2	-0.5	3.2
Falls in the last year	3.9	5.2	8.5	1.4	2.9
Hayfever, allergic rhinitis or eczema	3.7	8.0	12.2	-1.9	-3.5
Myopia	3.6	5.2	8.4	-2.9	-1.4
Medication: Ibuprofen (e.g. Nurofen)	3.4	4.3	7.0	2.6	-1.2
Depression (self-reported)	3.4	4.1	8.1	-2.8	0.4
Body Mass Index (BMI) (2010)	3.3	4.5	8.9	3.0	-0.2
Hayfever/allergic rhinitis (self-reported)	3.2	4.3	4.9	-1.9	-2.2
Breastfed as a baby	3.2	4.0	8.0	-0.1	2.8
Supplements: Zinc	2.9	3.2	4.2	-1.5	-2.0
Length of working week for main job	2.9	3.2	6.4	2.5	0.3
Deep venous thrombosis (DVT) (self-reported)	2.8	3.5	7.0	-0.3	2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.2	7.8	-2.8	-0.7
Chronic bronchitis/emphysema (mother)	2.5	2.9	5.6	-0.6	2.4
Mouth/teeth dental problems: Loose teeth	2.5	3.0	5.9	-0.2	-2.4
Financial situation satisfaction	2.4	3.0	5.8	2.4	-0.4
Medication for cholesterol	2.3	3.5	5.1	1.4	-2.2
Had menopause	2.2	2.7	3.0	-1.7	1.6
Illnesses of mother	2.2	2.8	5.4	-0.4	-2.3
Eye problems/disorders: None of the above	2.2	2.5	4.2	1.0	2.0
Tinnitus: Yes, now most or all of the time	2.2	2.6	5.2	-2.3	-0.0
Alzheimer’s Disease (in mother)	2.1	2.5	3.3	1.3	-1.8
Type 2 Diabetes (T2D) (2012)	2.1	2.5	4.7	2.2	-0.4
Medication: Atenolol	2.1	2.6	3.8	1.2	2.0
Blood clot in the leg (DVT)	2.1	2.7	5.2	-0.4	2.3
Ever taken oral contraceptive pill	2.1	2.4	2.7	1.6	-1.4
Ever smoked	2.1	3.7	6.8	2.6	-0.7
Wheeze or whistling in the chest in last year	2.0	3.6	5.7	2.4	-1.3
Wears glasses or contact lenses	2.0	2.3	2.4	-1.4	-1.6
High cholesterol (Self-reported)	2.0	3.6	6.3	0.9	2.5
Alzheimer’s Disease (including proxy)	1.9	2.8	4.2	1.1	-2.1
Prospective memory result	1.9	2.3	3.9	-0.8	2.0
Shortness of breath walking on level ground	1.9	2.3	2.3	1.5	1.5
Medication: Ibuprofen	1.9	2.3	3.5	1.9	-1.0
Knee pain experienced in last month	1.9	3.0	6.0	2.5	-0.1
LDL Cholesterol	1.8	2.9	5.0	-0.9	-2.2
Pack years adult smoking proportion	1.8	2.8	5.5	2.3	-0.3
Current tobacco smoking	1.8	2.9	5.6	2.4	0.4
Suffer from ‘nerves’	1.8	2.8	5.6	-2.4	0.1
Friendships satisfaction	1.8	2.3	4.5	0.0	2.1
Medication for hormone replacement therapy	1.7	1.9	2.3	-1.2	1.5
Intelligence (Savage-Jansen 2018)	1.6	4.8	4.9	-2.2	-2.2
Verbal and Numeric Reasoning (VNR)	1.6	3.8	4.6	-1.7	-2.1
Qualifications: None of the above	1.6	3.4	6.8	0.1	2.6
Fluid intelligence score	1.6	3.3	4.1	-1.6	-2.0
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	4.9	-0.5	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	4.2	-2.0	-0.3
Number of children fathered	1.6	1.9	2.1	1.5	1.3
Medication: Seretide 50 evohaler	1.6	1.8	2.7	1.0	-1.6
Alcohol intake frequency.	1.6	3.6	4.1	-1.8	2.0
Prostate Cancer	1.5	2.1	2.2	-1.4	1.5
Allergy or Eczema	1.5	3.8	4.8	-1.7	-2.2
Medication: Co-codamol	1.5	1.8	3.0	-0.7	1.7
Supplements: Glucosamine	1.5	1.9	2.3	1.5	-1.2
Breast cancer (self-reported)	1.5	1.8	3.3	1.8	0.5
Blood Red Count	1.4	13.9	27.7	-5.3	0.3
Diabetes (father)	1.4	1.8	1.8	-1.3	1.4
High blood pressure (mother)	1.4	1.9	3.6	-0.6	1.9
Past tobacco smoking	1.4	2.6	5.2	-2.3	0.3
Worry too long after embarrassment	1.4	2.3	4.6	2.2	0.2
Migraine (self-reported)	1.4	1.7	3.4	0.3	-1.8
Medication: Paracetamol	1.4	2.1	3.9	2.0	-0.5
Maternal smoking around birth	1.3	1.8	3.6	1.9	0.1
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	2.6	-0.7	-1.6
Supplements: Vitamin C	1.3	1.5	3.1	-0.2	-1.8
Smoking status: Current	1.3	2.1	4.2	2.0	0.4
Miserableness	1.3	2.2	3.5	1.9	-1.0
Age started oral contraceptive pill	1.3	1.6	3.0	-0.5	1.7
Alcohol drinker status: Previous	1.3	1.5	2.0	-1.4	1.0
Taking other prescription medications	1.2	1.8	2.0	-1.3	-1.4
Allergy	1.2	2.8	4.4	1.1	2.1
Lung cancer (father)	1.2	1.4	2.6	1.6	0.4
Medication: Blood pressure	1.2	2.3	3.9	-0.9	2.0
Pack years of smoking	1.2	1.8	3.6	1.9	0.0
Lupus	1.1	1.7	2.3	1.1	-1.5
Smoking Status	1.1	2.6	5.0	2.2	-0.3
Townsend deprivation index at recruitment	1.1	1.5	2.2	-1.5	0.9
Qualifications: CSEs or equivalent	1.1	1.5	1.6	1.3	-1.2
Financial difficulties in last 2 years	1.1	1.5	2.5	1.6	0.7
Medication: Simvastatin	1.1	1.6	2.5	0.8	1.6
Eye problems/disorders: Cataract	1.1	1.3	2.6	-0.3	-1.6
Alcohol drinker status: Never	1.1	1.3	2.6	-0.3	1.6
Basal cell carcinoma (self-reported)	1.1	1.3	2.1	-1.5	-0.6
Reaction Time	1.0	1.9	3.8	2.0	0.1
Neuroticism (2016)	1.0	1.4	2.4	-0.7	1.5
Rheumatoid Arthritis	1.0	1.4	2.8	-0.2	-1.7
Sensitivity / hurt feelings	1.0	1.8	2.6	-1.0	1.6
Pulse wave Arterial Stiffness index	1.0	1.1	2.2	-1.5	0.2
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.6	-1.9	0.3
Pulse wave peak to peak time	1.0	1.2	2.3	1.5	-0.3
Alzheimer’s Disease (in father)	0.9	1.0	1.8	1.3	-0.4
Major Depression (MDD)	0.9	1.0	1.7	-1.3	0.6
Relative age of first facial hair	0.9	1.9	3.5	-1.9	-0.5
Medication: Cholesterol lowering	0.9	1.5	2.9	0.1	1.7
Medication: Amlodipine	0.9	1.3	1.9	-1.4	0.8
Health satisfaction	0.9	1.2	1.3	1.1	-1.1
Medication for pain relief, constipation, heartburn	0.9	1.5	2.2	-1.5	0.8
Smoking status: Previous	0.9	1.3	1.6	1.3	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.2	0.3	-1.5
Breast Cancer	0.8	1.9	3.6	-1.9	0.5
Hypothyroidism (self reported)	0.8	1.9	3.6	-1.9	-0.4
Chronotype (morning person)	0.8	1.9	3.7	-1.9	-0.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.7	-1.3	0.1
Average weekly fortified wine intake	0.8	1.0	1.9	0.1	-1.4
Nervous feelings	0.8	1.5	2.7	-1.6	-0.6
Hearing difficulty/problems with background noise	0.8	1.3	2.1	0.7	-1.5
Alcohol intake versus 10 years previously	0.8	1.2	2.3	-0.2	1.5
Loud music exposure frequency	0.8	0.8	1.1	0.8	-1.0
Medication: Paracetamol	0.8	1.3	2.4	1.6	-0.4
Birth weight	0.8	1.8	3.6	0.2	1.9
Emphysema/chronic bronchitis	0.8	0.9	1.4	0.6	1.2
Medication: Omeprazole	0.8	0.9	1.8	-0.0	-1.4
Had major operations	0.8	0.9	1.4	1.2	-0.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.2	1.1	0.7
Ever had bowel cancer screening	0.8	1.0	1.0	1.0	-1.0
Mineral and other dietary supplements	0.8	1.0	2.1	-0.1	1.4
Medication: Aspirin	0.8	1.0	1.9	-0.3	1.4
Mean Putamen Volume	0.7	0.8	1.4	1.2	0.4
Triglycerides	0.7	1.1	2.2	0.1	-1.5
Tense / ‘highly strung’	0.7	1.2	2.0	-1.4	0.6
Pulse wave reflection index	0.7	0.9	1.3	-0.7	1.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.9	0.6	-1.4
Neck or shoulder pain in last month	0.7	0.9	1.8	-0.3	1.3
Age at last live birth	0.7	1.0	1.2	1.1	0.9
Long-standing illness, disability or infirmity	0.7	1.1	2.1	-0.4	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.1	-0.2	-1.5
Number of self-reported non-cancer illnesses	0.7	1.3	1.4	-1.0	-1.2
Mother’s age at death	0.7	0.9	1.7	-1.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.8	0.2	-1.3
HbA1C	0.6	0.7	0.9	-0.9	0.7
BMI	0.6	3.7	4.1	1.8	-2.0
Lung FEV1/FVC ratio	0.6	3.0	6.0	2.5	0.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.5	-1.2	-0.1
Multivitamins +/- minerals	0.6	0.7	1.4	-1.2	-0.2
Arm fat mass (right)	0.6	2.4	4.4	0.7	-2.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.3	0.5	1.2
Medication: Aspirin	0.6	0.8	1.5	-0.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.4	1.6	-0.2
Arm fat percentage (left)	0.6	2.4	4.8	0.2	-2.2
Hearing aid user	0.6	0.7	1.1	0.6	-1.0
Average weekly beer plus cider intake	0.6	0.8	1.5	1.2	0.4
Fasting Glucose	0.5	0.6	1.0	1.0	-0.5
Primary Biliary Cirrhosis	0.5	0.6	1.3	-1.1	-0.1
Heel T-Score	0.5	3.6	6.6	-2.6	-0.8
Vitamin and mineral supplements	0.5	0.7	1.5	1.2	0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.3	0.1	-1.1
High blood pressure	0.5	1.5	2.9	0.1	1.7
Arm fat percentage (right)	0.5	2.1	4.0	0.5	-2.0
Father’s age at death	0.5	0.6	0.9	-0.6	-0.9
Medication: Lansoprazole	0.5	0.6	0.7	-0.7	0.8
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.3	0.2	1.1
Comparative body size at age 10	0.5	1.3	1.6	1.0	-1.3
Age at first live birth	0.5	0.9	1.1	0.9	1.1
Medication: Blood pressure	0.5	0.9	1.5	-0.6	1.2
Hypertension (Self-reported)	0.5	1.4	2.8	0.1	1.7
Mood swings	0.5	0.9	1.1	1.1	-0.8
Qualifications: nursing, teaching	0.5	0.8	1.6	0.2	-1.3
Arm fat mass (left)	0.5	2.2	4.0	0.5	-2.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.7	-0.1	-1.6
Bipolar Disorder (2018)	0.4	0.6	1.2	0.1	-1.1
Age at First Birth	0.4	0.5	0.9	1.0	-0.3
Bipolar Disorder (2011)	0.4	0.4	0.6	-0.4	0.7
Number of treatments/medications taken	0.4	0.7	1.1	-0.4	-1.1
Average weekly spirits intake	0.4	0.4	0.9	0.1	-0.9
Severe depression (siblings)	0.4	0.5	0.6	-0.5	-0.8
Trunk fat percentage	0.4	1.6	3.2	0.1	-1.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.8	-0.3	-0.9
Medication: Levothyroxine sodium	0.4	0.7	0.9	-1.0	0.7
Number of incorrect matches in round	0.4	0.7	1.3	-0.2	-1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.8	-0.3	0.9
Medication: Ramipril	0.4	0.5	1.0	0.3	1.0
Illnesses of siblings	0.4	0.5	0.8	-0.5	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	-1.0	0.5
Noisy workplace	0.4	0.6	1.1	-0.0	1.1
Gout (self-reported)	0.4	0.5	0.9	1.0	-0.4
Forced vital capacity (FVC), Best measure	0.4	1.3	2.7	0.2	-1.6
Body fat percentage	0.4	1.4	2.6	0.4	-1.6
Mean time to correctly identify matches	0.4	0.9	1.1	1.1	0.8
Heart disease (mother)	0.4	0.5	0.9	-0.9	-0.2
Chest pain or discomfort	0.4	0.6	0.9	-0.5	-0.9
Diabetes diagnosed by doctor	0.4	0.6	0.6	-0.8	0.8
Commuting to job workplace: Public transport	0.4	0.5	0.9	-1.0	-0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	0.9	-0.6
Unable to work because of sickness or disability	0.4	0.6	1.1	1.1	-0.0
Commuting to job workplace: Cycle	0.4	0.5	0.8	-0.3	0.9
Cholesterol lowering medication	0.4	0.6	0.7	0.7	0.8
Depressed Affect (Nagel 2018)	0.3	0.5	0.6	0.8	-0.7
Schizophrenia (2018)	0.3	0.7	1.1	-1.1	0.4
Schizophrenia (2014)	0.3	0.6	1.2	-1.1	0.3
Hearing difficulty/problems: Yes	0.3	0.5	0.9	-1.0	-0.4
Fed-up feelings	0.3	0.6	1.2	1.1	-0.1
Stomach or abdominal pain in last month	0.3	0.4	0.5	-0.5	-0.7
Body mass index (BMI)	0.3	1.1	1.2	1.0	-1.1
Trunk fat mass	0.3	1.5	2.9	0.4	-1.7
Alcohol usually taken with meals	0.3	0.4	0.8	-0.3	-0.9
Had other major operations	0.3	0.4	0.6	0.4	0.8
Heart attack	0.3	0.4	0.5	0.5	0.7
Pain all over the body in last month	0.3	0.3	0.5	-0.7	-0.3
Diabetes (self-reported)	0.3	0.5	0.6	-0.8	0.7
Number of live births	0.3	0.4	0.7	0.9	0.1
Happiness	0.3	0.3	0.4	0.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.6	0.3	-1.3
Impedance of arm (left)	0.3	1.5	1.5	-1.2	-1.2
Hair/balding pattern: Pattern 4	0.3	0.7	0.7	-0.8	-0.8
Headache pain in last month	0.3	0.5	0.7	-0.5	-0.9
Glaucoma (self-reported)	0.3	0.4	0.5	0.6	0.7
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.3	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.4	0.6	-0.5
Whole body fat mass	0.3	1.3	2.2	0.6	-1.5
Illnesses of father: Heart disease	0.3	0.4	0.7	0.9	-0.0
Loneliness, isolation	0.3	0.4	0.4	-0.7	-0.7
Average weekly champagne plus white wine intake	0.3	0.4	0.9	-0.9	-0.1
Medication: Atorvastatin	0.3	0.3	0.7	-0.8	-0.2
Pain experienced in last month	0.3	0.5	1.1	-0.0	1.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	0.4	0.7
Leg fat mass (left)	0.3	1.0	1.4	0.7	-1.2
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	0.5	0.4
Worry (Nagel 2018)	0.2	0.3	0.4	-0.6	0.5
Coronary Artery Disease (CAD)	0.2	0.2	0.4	0.6	-0.1
HDL Cholesterol	0.2	0.3	0.4	0.6	0.4
Systolic Blood Pressure	0.2	0.8	1.5	0.2	1.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.8	-0.2
Hand grip strength (left)	0.2	0.4	0.7	0.4	-0.8
Systolic blood pressure, automated reading	0.2	0.7	1.3	-0.2	1.1
Impedance of leg (right)	0.2	0.8	1.2	-1.1	0.7
Hand grip strength (right)	0.2	0.4	0.8	0.9	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.2	0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.5	-0.2	-0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.6	-0.1
Waist circumference	0.2	0.8	1.2	1.1	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	-0.7	-0.3
Forced vital capacity (FVC)	0.2	0.7	1.4	0.0	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	0.6	-0.7	-0.8
Weight	0.2	0.9	0.9	0.9	-1.0
Hip circumference	0.2	0.7	1.3	0.2	-1.1
Time employed in main current job	0.2	0.2	0.4	-0.6	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.8	0.9	-0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.2	0.3	-1.1
Pulse rate	0.2	0.4	0.7	-0.9	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.6	0.3
Asthma	0.2	0.3	0.6	-0.1	-0.8
Exposure to tobacco smoke at home	0.2	0.2	0.3	-0.2	0.6
High blood pressure (siblings)	0.2	0.3	0.5	0.7	0.3
Qualifications: College or University degree	0.2	0.7	1.4	0.2	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.7	-0.1
Leg fat mass (right)	0.2	0.7	0.9	0.7	-0.9
Comparative height size at age 10	0.2	0.9	1.6	1.3	-0.4
Overall health rating	0.2	0.5	0.8	0.4	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.6	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.2	-0.7
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.6	-0.2
Medication: Lisinopril	0.2	0.2	0.4	-0.6	0.3
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.0	0.6
Leg fat percentage (left)	0.2	0.8	1.4	0.4	-1.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.4	-0.7	-0.3
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.6	-0.2
Supplements: Calcium	0.2	0.2	0.2	-0.4	-0.4
Impedance of whole body	0.2	1.0	1.4	-1.2	-0.8
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	-0.7	-0.4
Depression (Nagel 2018)	0.1	0.1	0.1	0.4	-0.4
Neuroticism (Nagel 2018)	0.1	0.2	0.3	0.2	0.5
Crohns Disease (2017)	0.1	0.2	0.2	0.4	0.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.2	0.4	-0.5
Ulcerative Colitis (UC)	0.1	0.3	0.5	-0.1	-0.7
Crohns Disease (2012)	0.1	0.2	0.4	0.6	0.2
Ulcerative Colitis	0.1	0.2	0.3	0.5	-0.2
Blood White Count	0.1	0.8	1.3	-1.1	0.4
Waist Hip Ratio (WHR)	0.1	0.5	0.6	0.8	0.7
Cardiovascular Disease	0.1	0.3	0.5	-0.3	0.7
Lung FVC	0.1	0.3	0.5	-0.4	-0.7
Neuroticism	0.1	0.2	0.3	0.5	-0.1
Tanning	0.1	1.6	2.9	-1.7	0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.3	0.5
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.4	-0.2
Angina	0.1	0.1	0.2	0.1	0.5
Diabetes (mother)	0.1	0.2	0.3	0.1	0.5
Relative age voice broke	0.1	0.1	0.2	0.1	-0.5
Age when periods started (menarche)	0.1	0.4	0.4	-0.7	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	-0.6	-0.4
Sitting height	0.1	0.4	0.4	0.7	-0.7
Impedance of leg (left)	0.1	0.6	1.1	-1.0	0.4
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	0.6	-0.1
Mouth/teeth dental problems	0.1	0.1	0.2	0.4	0.2
Neuroticism score	0.1	0.2	0.2	0.4	-0.4
Impedance of arm (right)	0.1	0.5	0.7	-0.5	-0.8
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	-0.5	-0.5
Birth weight of first child	0.1	0.2	0.3	0.3	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	0.3	0.3
Leg fat percentage (right)	0.1	0.3	0.6	0.3	-0.8
Angina (self-reported)	0.1	0.1	0.2	0.2	0.4
Medication: Allopurinol	0.1	0.1	0.1	-0.4	0.2
Pulse rate, automated reading	0.1	0.3	0.4	-0.4	-0.6
Family relationship satisfaction	0.1	0.1	0.2	-0.2	-0.5
Leg pain on walking	0.1	0.1	0.1	0.1	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.2	-0.4
Leg fat-free mass (right)	0.1	0.3	0.4	0.4	-0.6
Average weekly red wine intake	0.1	0.1	0.1	0.3	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	-0.6	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.3	-0.1
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.3	-0.2
Back pain experienced in last month	0.1	0.1	0.1	0.4	0.2
Asthma (self-reported)	0.1	0.3	0.5	-0.4	-0.7
Osteoporosis (self-reported)	0.1	0.1	0.1	0.4	-0.3
Medication: Gliclazide	0.1	0.1	0.1	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	0.2	-0.7
Leg predicted mass (right)	0.1	0.3	0.4	0.4	-0.6
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.4	-0.3
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.6	0.1
Number of operations (self-reported)	0.1	0.1	0.1	-0.3	0.3
Irritability	0.1	0.2	0.3	0.6	-0.0
Risk taking	0.1	0.1	0.2	-0.5	-0.1
Diastolic blood pressure, automated reading	0.1	0.5	0.8	0.3	0.9
Heart disease (siblings)	0.1	0.2	0.3	0.2	0.5
Arm predicted mass (left)	0.1	0.3	0.6	0.7	0.1
Ovarian Cancer	0.0	0.0	0.0	-0.0	0.2
Blood Eosinophil Count	0.0	0.0	0.1	0.3	0.0
Blood Platelet Count	0.0	0.3	0.6	0.8	0.2
Height	0.0	0.4	0.7	-0.8	-0.4
Respiratory disease	0.0	0.0	0.0	-0.2	-0.2
Hair Pigment	0.0	1.3	2.2	0.6	1.5
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.2	-0.1
Medication: Metformin	0.0	0.1	0.1	-0.1	-0.4
Leg fat-free mass (left)	0.0	0.2	0.3	0.3	-0.6
Leg predicted mass (left)	0.0	0.2	0.3	0.4	-0.5
Trunk fat-free mass	0.0	0.1	0.2	0.4	0.1
Worrier / anxious feelings	0.0	0.1	0.1	0.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	0.3	-0.2
Trunk predicted mass	0.0	0.1	0.2	0.4	-0.0
Standing height	0.0	0.0	0.0	0.1	-0.2
Peak expiratory flow (PEF)	0.0	0.0	0.1	0.2	-0.2
Arm fat-free mass (right)	0.0	0.1	0.1	0.4	-0.2
Arm predicted mass (right)	0.0	0.0	0.0	0.1	0.1
Number of full sisters	0.0	0.0	0.0	0.1	0.0
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.1	0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.0	-0.0	0.2
Whole body fat-free mass	0.0	0.1	0.2	0.4	-0.2
Osteoarthritis (self-reported)	0.0	0.0	0.1	-0.2	0.0
Whole body water mass	0.0	0.1	0.2	0.5	-0.2
Guilty feelings	0.0	0.1	0.1	-0.1	-0.4
Basal metabolic rate	0.0	0.3	0.3	0.5	-0.5
Arm fat-free mass (left)	0.0	0.1	0.3	0.5	-0.1
Ever depressed for a whole week	0.0	0.0	0.1	-0.1	-0.3

Hub : Genes

C1orf226

Models

Trait associations