TWAS hub - FCGR2B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0890	0.0380	7.8e-03	0.018	NA	0.003	NA	0.004	1.1e-02	NA	1.6e-01	NA	1.4e-01
2	GTEx	Whole Blood	0.2600	0.0540	6.7e-08	0.100	NA	0.139	NA	0.115	1.7e-09	NA	9.4e-13	NA	1.0e-10
3	METSIM	Adipose	0.0651	0.0277	2.0e-03	0.029	0.019	0.018	0.022	0.023	2.8e-05	5.4e-04	8.6e-04	2.6e-04	1.7e-04
4	NTR	Blood	0.2536	0.0338	0.0e+00	0.065	0.156	0.183	0.174	0.169	5.5e-20	6.1e-48	7.9e-57	1.1e-53	4.2e-52
5	YFS	Blood	0.5417	0.0429	0.0e+00	0.208	0.334	0.379	0.310	0.355	3.8e-66	1.7e-113	9.1e-133	5.2e-104	2.7e-122
6	TCGA	Breast Invasive Carcinoma	0.0658	0.0289	6.5e-04	0.009	0.017	0.022	NA	0.016	4.1e-03	1.6e-04	2.3e-05	NA	2.2e-04
7	TCGA	Colon Adenocarcinoma	0.1090	0.0520	3.9e-03	0.005	0.017	-0.004	NA	0.000	1.6e-01	3.4e-02	7.5e-01	NA	3.1e-01
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.1358	0.0511	6.4e-05	0.000	0.018	0.034	NA	0.005	3.1e-01	3.3e-03	9.2e-05	NA	7.3e-02
9	TCGA	Lung Adenocarcinoma	0.1124	0.0428	1.5e-03	0.044	0.026	0.039	NA	0.040	7.1e-06	4.5e-04	2.3e-05	NA	1.7e-05
10	TCGA	Lung Squamous Cell Carcinoma	0.1232	0.0512	9.5e-04	0.019	0.019	0.020	NA	0.018	2.8e-03	2.5e-03	2.1e-03	NA	3.4e-03
11	TCGA	Prostate Adenocarcinoma	0.0358	0.0205	6.1e-03	0.011	0.013	0.016	NA	0.015	2.1e-02	1.4e-02	6.9e-03	NA	8.5e-03
12	TCGA	Thyroid Carcinoma	0.1290	0.0510	9.5e-05	0.008	0.050	0.033	NA	0.015	4.7e-02	1.2e-05	3.4e-04	NA	1.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Birth weight	7.7	16.6	28.4	-2.9	-4.0	-3.5	-4.0	-5.3	-4.2	-0.6	-5.3	-3.8	-4.9	-5.0	-3.2
Rheumatoid Arthritis	7.5	10.3	16.6	2.9	4.0	4.0	3.2	4.1	3.4	0.7	3.7	2.8	3.5	2.9	1.5
Lupus	5.1	7.7	24.6	-2.4	1.8	-5.0	1.1	0.7	-3.7	-2.0	-2.6	-2.8	-3.5	-3.1	-1.6
Mouth/teeth dental problems: Mouth ulcers	4.4	7.0	16.8	-0.9	-1.3	-1.7	-0.6	-1.2	-3.3	-3.2	-2.6	-3.5	-3.8	-4.1	-2.4
Mineral and other dietary supplements	4.4	5.9	10.3	2.0	3.0	1.9	1.8	3.0	2.9	-0.9	3.2	2.2	2.3	1.7	3.0
Supplements: Vitamin C	4.1	4.9	11.1	-1.3	-1.8	-2.1	-2.2	-2.1	-2.6	-0.1	-3.3	-1.7	-2.6	-2.5	-2.5
Hypothyroidism/myxoedema (self-reported)	4.0	7.8	15.1	-2.0	-2.3	-3.6	-2.8	-2.6	-2.5	0.7	-3.5	-1.7	-3.5	-3.9	-2.6
Hypothyroidism (self reported)	3.8	8.7	17.8	-2.1	-2.3	-4.1	-3.2	-2.6	-2.6	0.5	-3.5	-1.6	-3.8	-4.2	-2.5
Supplements: Fish oil (including cod liver oil)	3.8	5.0	11.2	-1.2	-2.9	-2.4	-2.3	-3.3	-2.5	-0.1	-2.3	-2.3	-2.2	-1.8	-1.8
Birth weight of first child	3.5	6.4	23.6	-1.1	-4.9	-3.2	-3.3	-3.6	-0.5	1.7	-2.5	0.1	-0.9	-1.4	-2.2
Multivitamins +/- minerals	3.1	3.9	9.2	-3.0	-2.1	-1.6	-2.7	-2.2	-2.0	-0.8	-1.6	-2.9	-1.9	-0.3	0.4
LDL Cholesterol	3.0	4.7	9.1	2.3	2.8	2.9	2.5	3.0	1.6	1.4	2.3	1.4	2.0	1.8	0.6
Vitamin and mineral supplements	3.0	4.1	9.5	1.9	2.0	2.2	2.2	2.1	2.1	0.5	3.1	1.7	2.1	1.8	1.5
Commuting to job workplace: Walk	3.0	3.3	10.3	-1.7	-2.3	-1.4	-3.2	-2.4	-1.6	0.0	-1.2	-2.1	-1.9	-1.2	0.3
Supplements: Glucosamine	2.7	3.5	9.1	-2.1	-1.4	-1.1	-0.8	-1.2	-2.7	-0.5	-3.0	-1.8	-2.0	-1.6	-2.3
Neck or shoulder pain in last month	2.7	3.9	8.3	-1.5	-2.3	-2.9	-2.6	-1.9	-1.8	-0.4	-2.4	-1.6	-1.9	-1.8	-1.4
Ulcerative Colitis (UC)	2.6	4.9	28.7	2.3	-1.0	5.4	0.6	-0.8	1.3	3.0	-2.0	1.3	0.6	-1.6	-1.9
Falls in the last year	2.6	3.5	10.5	-1.4	-0.1	-1.9	-0.6	-0.2	-2.0	-2.0	-3.2	-0.2	-2.4	-3.0	-1.9
Health satisfaction	2.6	3.4	15.2	1.0	2.6	1.8	3.9	3.0	0.3	-0.1	0.0	1.1	1.2	0.7	-1.4
Unable to work because of sickness or disability	2.6	3.3	13.8	0.9	3.7	0.7	2.1	2.8	1.1	-1.7	0.9	1.8	1.4	0.9	1.3
HbA1C	2.4	2.7	5.8	-2.4	-2.1	-0.6	-2.4	-2.4	-1.6	-0.4	-1.2	-1.5	-1.8	-0.7	-0.4
Blood Red Count	2.4	23.4	46.5	4.5	3.6	4.9	4.8	6.8	5.0	1.7	6.0	3.1	5.1	5.6	4.9
Lung FEV1/FVC ratio	2.4	12.2	33.2	-4.1	-5.1	-0.3	-5.3	-5.8	-2.6	-0.8	-3.5	-2.5	-2.8	-2.5	-1.4
Medication: Levothyroxine sodium	2.4	4.1	8.1	-0.8	-2.0	-2.8	-2.3	-2.8	-1.2	0.9	-2.5	-0.8	-2.1	-2.8	-1.5
Leg fat percentage (right)	2.4	8.6	12.4	-2.6	-3.4	-3.5	-2.0	-3.2	-3.3	-1.5	-3.1	-2.8	-3.5	-3.3	-2.2
Medication for pain relief, constipation, heartburn	2.3	3.9	9.1	1.9	-0.4	1.9	-0.7	-0.6	2.8	2.1	2.7	1.1	2.1	2.2	3.0
Mean Putamen Volume	2.2	2.5	5.9	1.7	-0.5	1.7	1.3	0.2	2.2	0.6	2.0	2.4	2.4	1.3	0.1
Time employed in main current job	2.2	2.5	8.0	0.5	2.8	1.5	2.2	1.5	1.5	1.1	1.7	1.1	1.2	1.3	1.3
Heart disease (mother)	2.2	2.7	7.0	1.7	0.1	1.3	0.6	1.5	2.6	-0.1	1.5	2.6	2.6	1.1	1.1
Blood White Count	2.1	15.3	58.5	-1.4	-6.3	-0.4	-7.7	-7.2	2.7	1.5	-2.5	1.6	-0.3	-2.2	2.9
Leg fat percentage (left)	2.1	7.4	10.6	-2.4	-3.3	-3.1	-1.7	-3.1	-2.9	-1.6	-3.0	-2.4	-3.2	-3.2	-2.0
Illness, injury, bereavement, stress in last 2 years	2.0	2.4	8.3	2.1	-1.2	-0.9	-1.2	-1.0	2.4	1.3	0.3	2.9	1.9	0.3	0.4
Serious illness, injury or assault to yourself	1.9	2.3	6.5	-0.7	2.6	2.0	1.3	2.0	-0.6	-1.7	1.1	-1.0	0.7	2.0	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.2	8.4	0.2	0.1	-1.3	1.4	0.7	-2.6	-0.6	-2.1	-1.0	-2.5	-2.9	-2.5
Noisy workplace	1.9	2.3	10.8	1.3	3.3	0.2	2.6	1.8	-0.2	1.2	0.3	0.5	1.1	1.0	-1.0
Leg fat mass (right)	1.9	7.5	12.9	-2.7	-2.8	-3.6	-1.7	-2.8	-3.3	-1.1	-2.8	-2.6	-3.4	-2.9	-2.2
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.2	0.2	-1.9	-2.1	-1.3	-2.3	-1.0	0.1	-1.8	-1.2	-1.6	-2.1	-1.0
HDL Cholesterol	1.8	3.0	7.1	2.1	1.2	1.1	1.1	2.2	2.0	0.5	2.0	1.4	1.8	1.7	2.7
Primary Biliary Cirrhosis	1.8	2.5	7.5	1.2	2.2	0.3	2.3	2.7	1.2	-0.6	1.9	1.3	1.4	1.2	0.5
Medication: Paracetamol	1.8	3.1	6.9	-1.2	0.3	-1.9	0.2	0.5	-2.6	-2.5	-1.8	-1.1	-2.5	-2.2	-1.6
Body fat percentage	1.8	7.1	11.8	-2.6	-2.6	-3.1	-1.1	-2.6	-3.3	-1.5	-2.9	-2.5	-3.4	-3.1	-2.2
Hearing aid user	1.8	2.0	5.3	-0.7	-0.1	-2.3	-0.9	-0.8	-1.3	-1.8	-1.4	-1.2	-1.9	-2.2	-0.7
Bipolar Disorder or Schizophrenia	1.7	4.1	8.6	-2.9	-0.6	-2.0	-1.6	-1.8	-2.5	-0.9	-2.8	-2.4	-2.1	-1.6	-1.8
Irritable Bowel Disease (IBD)	1.7	4.1	16.6	1.6	-2.5	4.1	-0.4	-2.0	0.9	1.4	-2.8	0.8	-0.0	-2.3	-1.7
Reaction Time	1.7	3.3	9.5	-0.8	0.5	-2.2	2.0	1.1	-2.7	-0.9	-0.9	-1.4	-2.2	-1.7	-3.1
Ulcerative Colitis	1.7	2.5	10.1	-0.1	-1.0	3.2	0.7	-0.9	-0.3	2.5	-2.4	0.1	-0.5	-1.1	-1.9
Blood Platelet Count	1.7	19.4	47.2	-1.2	-4.5	-4.2	-4.3	-6.1	-2.8	-0.8	-6.6	-2.4	-4.4	-6.9	-3.8
Medication: Cholesterol lowering	1.7	2.6	8.5	-0.2	2.5	1.8	2.9	2.2	0.3	-0.9	0.8	1.4	1.4	1.6	-0.5
Loud music exposure frequency	1.7	1.8	6.5	-0.2	-0.2	-0.5	-0.1	-0.8	-1.4	-2.1	-2.5	0.3	-1.4	-2.4	-0.7
Leg fat mass (left)	1.7	6.7	11.2	-2.6	-2.7	-3.4	-1.5	-2.7	-3.0	-1.2	-2.7	-2.4	-3.2	-2.8	-2.1
Bipolar Disorder (2018)	1.6	2.6	5.7	-2.4	-0.2	-0.6	-1.7	-1.5	-1.6	-0.4	-2.3	-2.1	-2.0	-1.8	0.0
Ovarian Cancer	1.6	2.1	5.7	-2.3	-1.9	-1.2	-2.4	-1.8	-1.0	-0.1	-1.2	-1.6	-0.4	0.6	-0.4
Hand grip strength (left)	1.6	4.3	8.0	-1.1	-2.7	-2.8	-2.7	-2.8	-1.6	-0.9	-1.4	-2.0	-2.4	-2.2	0.2
Chronic bronchitis/emphysema (father)	1.6	1.8	5.9	1.8	0.9	0.1	2.4	1.6	1.6	-0.2	0.8	2.1	1.2	0.1	-0.5
Heart attack	1.6	2.0	5.1	0.1	2.1	0.8	2.1	1.5	0.7	-0.3	1.7	0.6	1.5	2.3	1.1
Medication: Simvastatin	1.6	2.4	6.7	-1.1	1.7	2.6	2.5	1.5	0.0	0.7	1.5	0.2	1.3	2.2	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	7.1	-2.1	-0.5	-1.7	-1.0	-0.6	-1.4	-0.0	-2.7	-0.4	-1.0	-1.0	-1.9
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	8.2	0.2	-2.5	-1.5	-2.9	-2.7	0.5	1.1	-0.8	-0.9	-0.8	-1.6	1.0
Medication: Allopurinol	1.6	2.1	6.6	1.9	-0.1	-1.1	-0.0	0.5	1.8	-0.4	1.4	2.0	2.6	2.0	0.8
Mean time to correctly identify matches	1.6	3.1	11.4	-0.8	-0.9	-1.9	1.1	-0.3	-2.4	-0.3	-1.4	-1.2	-2.1	-2.2	-3.4
Chest pain or discomfort	1.6	2.2	11.6	-1.3	0.8	-1.6	0.4	0.2	-1.8	-3.4	-1.9	-0.9	-1.0	-1.1	-0.7
Back pain experienced in last month	1.6	2.3	6.2	0.4	1.1	-1.3	0.3	1.3	-1.8	-0.9	-2.0	-0.8	-1.7	-2.2	-2.5
Severe depression (siblings)	1.5	1.7	5.7	-2.4	-0.6	-0.8	-1.3	-1.2	-1.3	-1.6	-1.6	-1.6	-1.0	-0.3	-0.4
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	9.5	-1.3	-1.7	-1.1	-3.1	-1.5	0.8	0.1	-1.1	1.0	0.6	0.6	1.4
Illnesses of siblings	1.5	2.2	11.0	-0.1	-3.3	0.1	-2.7	-2.3	0.1	-0.0	0.1	-0.9	-0.4	-0.2	0.9
Medication: Lansoprazole	1.5	1.7	5.4	1.1	2.2	0.9	2.2	2.3	0.5	-0.4	1.2	0.6	0.1	-0.0	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	6.0	2.5	0.9	0.8	0.6	1.2	1.5	1.5	1.4	1.5	1.4	0.6	-0.1
Whole body fat mass	1.5	6.4	11.4	-2.6	-2.2	-3.4	-1.1	-2.3	-3.2	-1.3	-2.8	-2.2	-3.3	-2.8	-1.9
Number of full sisters	1.5	1.9	7.8	0.3	-0.3	1.2	0.1	-1.1	-0.9	-2.8	-0.9	-1.7	-1.5	-2.2	0.1
Risk taking	1.5	2.3	5.0	-1.0	-1.6	-2.1	-0.8	-0.9	-2.0	-0.5	-2.2	-1.4	-1.5	-1.3	-1.6
Pain experienced in last month	1.5	2.5	6.3	0.3	1.4	2.0	1.0	0.8	1.4	-0.3	2.4	0.2	1.6	2.5	2.3
Schizophrenia (2014)	1.4	3.0	10.8	-2.2	-1.3	-3.3	-1.6	-1.8	-1.7	-1.5	-1.5	-1.6	-1.2	-0.7	-1.2
Respiratory disease	1.4	3.1	10.8	3.3	1.4	-0.1	2.2	2.6	2.2	0.5	1.0	1.9	1.6	0.4	0.3
Relative age of first facial hair	1.4	2.8	10.3	0.2	-3.2	-1.3	-3.0	-3.1	-0.4	0.6	-0.8	-0.5	-0.5	-0.8	-0.8
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.5	0.0	1.9	-0.1	0.3	1.9	1.1	1.0	1.6	1.4	1.1	1.7	1.4
Medication: Atenolol	1.4	1.7	8.1	-1.1	-0.6	-0.7	-0.5	-1.1	-1.6	1.1	-1.6	-1.6	-0.5	-0.2	-2.8
Trunk fat mass	1.4	5.9	11.3	-2.8	-2.2	-3.4	-1.0	-2.4	-3.0	-1.0	-2.8	-1.9	-3.1	-2.6	-1.9
Length of working week for main job	1.4	1.6	8.1	-0.7	2.4	0.6	2.9	1.4	-0.9	-0.3	0.7	-0.5	-1.0	0.0	-0.1
Knee pain experienced in last month	1.4	2.3	7.7	-1.1	-0.5	-1.4	-0.6	-0.6	-1.7	-0.1	-2.7	0.1	-1.4	-1.8	-2.8
Arm fat percentage (left)	1.4	5.5	10.1	-2.3	-2.2	-2.5	-1.0	-2.1	-3.0	-1.0	-2.6	-2.2	-3.2	-2.8	-2.1
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.9	-0.1	1.9	0.6	2.2	1.4	0.6	-0.2	1.5	0.5	1.4	2.2	0.9
Alzheimer’s Disease (including proxy)	1.3	1.9	6.5	-0.5	2.2	-0.6	2.5	2.0	-0.8	-0.2	-0.5	0.3	-0.5	-0.5	-2.2
Lung FVC	1.3	6.7	14.7	1.7	3.8	2.7	2.0	3.1	1.8	-0.8	3.4	1.2	2.3	3.1	3.2
Trunk fat percentage	1.3	5.4	8.7	-2.5	-2.1	-2.8	-0.7	-2.3	-2.9	-1.3	-2.7	-1.9	-3.0	-2.6	-1.9
Financial difficulties in last 2 years	1.3	1.8	7.1	-0.2	0.7	-0.2	0.6	1.1	-1.4	-2.7	-0.5	-1.9	-1.8	-1.8	0.5
Arm fat percentage (right)	1.3	5.2	9.9	-2.4	-1.8	-2.2	-0.6	-1.8	-3.2	-1.2	-2.5	-2.3	-3.1	-2.6	-2.4
Asthma	1.3	2.6	6.6	2.6	1.3	0.2	1.4	1.8	2.4	0.2	1.6	1.7	2.1	1.2	1.0
Illnesses of mother	1.3	1.6	4.0	-0.7	-2.0	-0.7	-1.8	-1.8	-0.7	0.2	-1.1	-0.9	-1.6	-1.6	0.1
Headache pain in last month	1.3	2.2	6.7	-1.0	-0.4	-1.9	-0.3	-0.1	-1.6	-0.9	-2.2	-0.2	-2.3	-2.6	-1.4
Medication: Blood pressure	1.3	2.4	7.9	-0.1	2.0	1.6	2.1	2.0	0.0	0.6	1.4	0.5	1.6	2.8	-0.6
Leg pain on walking	1.3	1.6	4.9	1.4	0.8	-1.7	2.0	1.1	-0.3	-1.0	-0.9	0.2	-0.3	-1.2	-2.2
Loneliness, isolation	1.3	1.8	8.0	2.8	-0.4	-0.5	-0.1	-0.1	1.8	0.1	1.6	1.5	1.0	-0.4	1.9
Long-standing illness, disability or infirmity	1.3	2.0	7.2	0.9	2.7	1.7	2.5	1.3	0.1	-2.0	-0.2	0.4	0.8	0.1	-0.2
Asthma (self-reported)	1.3	2.5	7.1	2.7	1.4	0.3	1.4	1.8	2.4	-0.0	1.6	1.5	1.9	1.0	1.0
Major Depression (MDD)	1.2	1.4	5.2	0.3	2.3	1.7	0.7	2.0	0.2	1.8	0.5	0.1	0.4	0.8	-0.3
Supplements: Zinc	1.2	1.3	3.3	0.4	0.3	-1.8	1.8	0.9	-0.9	1.4	-0.9	-0.2	-0.8	-1.0	-1.7
Diabetes (father)	1.2	1.4	4.7	1.3	1.8	0.2	2.2	1.9	-0.1	-0.3	-0.7	1.3	-0.0	-0.9	-0.9
Arm fat mass (right)	1.2	5.1	9.0	-2.5	-1.9	-2.9	-0.8	-1.8	-3.0	-0.7	-2.5	-2.0	-3.0	-2.4	-2.0
Ever highly irritable/argumentative for 2 days	1.2	1.5	6.2	0.3	-0.3	-0.5	0.1	-0.1	-0.7	-0.6	-2.5	0.5	-1.2	-2.4	-1.6
Comparative body size at age 10	1.2	3.2	6.9	-1.2	-2.6	-1.9	-2.6	-2.1	-1.7	0.5	-1.0	-2.6	-1.8	-1.0	-0.4
Illnesses of siblings: Diabetes	1.2	1.5	6.1	0.3	1.9	-0.3	1.9	2.5	0.3	1.1	0.5	1.5	0.5	0.2	-0.5
Average weekly red wine intake	1.2	1.7	4.8	0.5	-0.3	-0.1	0.0	0.9	2.2	1.4	1.3	1.9	1.6	1.4	1.8
Osteoarthritis (self-reported)	1.2	1.6	4.1	-1.9	0.4	-0.9	-0.8	-0.7	-0.7	-2.0	-1.0	-1.4	-1.1	-0.9	1.9
Arm fat mass (left)	1.2	4.8	8.6	-2.4	-2.0	-2.7	-1.0	-2.0	-2.9	-0.8	-2.3	-2.0	-2.9	-2.3	-1.7
Number of self-reported non-cancer illnesses	1.2	2.1	7.2	-0.7	2.7	1.3	2.3	2.0	0.1	-0.5	0.4	1.2	1.3	1.6	-0.6
High cholesterol (Self-reported)	1.2	2.1	7.3	-2.7	1.7	1.9	1.5	1.1	-1.7	-0.5	0.7	-1.2	-0.3	1.5	-0.5
Heart disease (siblings)	1.2	1.5	5.0	-0.3	1.6	0.4	0.8	1.6	1.0	0.7	1.4	0.5	1.6	2.2	1.1
Medication: Ventolin 100micrograms inhaler	1.1	1.3	5.3	0.4	-1.3	-1.6	-0.4	-1.1	-0.1	0.2	-1.2	-1.3	-1.0	-2.3	-0.9
High blood pressure (siblings)	1.1	1.5	8.2	-1.0	2.9	-0.7	1.8	1.5	-0.6	-0.4	-0.4	0.8	-0.3	-0.5	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	12.0	0.2	0.5	1.2	-0.2	-0.1	-0.3	-3.5	-0.7	-0.0	-0.7	-1.3	0.6
Emphysema/chronic bronchitis	1.1	1.2	4.8	2.2	0.3	1.0	1.4	0.1	1.5	-0.5	1.4	1.1	0.9	-0.3	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	7.4	-0.8	-1.5	0.3	-1.5	-1.4	-0.1	2.7	-0.9	-0.4	0.0	0.7	-0.5
Smoking status: Previous	1.1	1.6	3.4	-1.3	-0.9	-0.2	-0.4	-1.2	-1.6	-0.2	-1.9	-0.6	-1.8	-1.4	-1.8
Ever had bowel cancer screening	1.1	1.3	3.1	0.6	1.7	1.1	1.8	0.8	0.1	0.9	-0.7	1.4	0.6	-0.7	-1.8
Medication: Paracetamol	1.1	1.7	4.0	-1.3	0.9	-1.2	0.3	0.6	-2.0	-2.0	-1.2	-0.7	-1.8	-1.4	-0.8
Medication: Atorvastatin	1.1	1.3	4.1	-1.0	1.8	1.1	1.4	2.0	-0.3	-0.8	0.8	0.5	0.6	1.7	0.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	7.3	0.8	-0.5	-1.7	0.2	0.2	-1.1	-0.0	-1.2	-0.9	-0.3	-1.3	-2.7
Schizophrenia (2018)	1.0	2.2	4.9	-1.9	-0.6	-2.0	-0.7	-1.2	-1.9	-0.9	-1.9	-1.4	-1.1	-0.6	-2.2
Schizophrenia vs Biploar Disorder	1.0	1.4	7.2	-0.0	1.2	0.0	2.0	0.9	-0.6	0.7	-0.1	0.0	0.8	1.1	-2.7
Alzheimer’s Disease (in father)	1.0	1.1	3.0	-0.7	1.5	-0.7	1.1	1.4	-0.8	-0.5	-0.9	0.1	-0.7	-1.1	-1.7
Ever used hormone-replacement therapy (HRT)	1.0	1.3	4.9	0.7	-0.2	-0.3	0.7	0.2	1.3	1.9	-0.4	2.2	1.7	0.5	-0.9
Hand grip strength (right)	1.0	2.6	9.4	-0.7	-2.4	-3.1	-1.7	-2.1	-1.2	-1.0	-1.2	-0.7	-1.4	-1.2	0.4
Relative age voice broke	1.0	1.6	5.3	-0.1	-1.9	-0.9	-1.7	-2.3	-1.1	0.6	-0.9	-1.4	-0.9	-0.8	-0.7
Mouth/teeth dental problems	1.0	1.6	4.7	0.6	-0.5	-0.4	0.0	0.7	1.5	1.2	1.9	1.3	1.5	2.2	1.4
Exposure to tobacco smoke at home	1.0	1.1	4.5	0.2	1.1	-0.6	1.6	1.1	-1.0	-0.2	-1.3	-0.1	-0.4	-0.6	-2.1
Tense / ‘highly strung’	1.0	1.6	5.4	-0.4	-0.9	-1.0	-0.5	-0.6	-1.0	-1.8	-1.9	-0.5	-1.2	-2.3	-1.4
Medication: Ibuprofen	1.0	1.2	4.1	-2.0	1.4	-0.8	0.5	0.8	-1.2	0.4	-1.5	-0.4	-0.5	0.1	-1.6
Medication: Aspirin	1.0	1.3	3.4	-0.4	1.8	-1.1	1.9	0.9	-0.4	-1.8	0.2	0.4	0.9	1.2	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	3.9	1.5	0.5	0.8	-0.1	1.1	1.1	-0.4	1.6	0.4	0.5	0.2	2.0
Medication: Gliclazide	1.0	1.1	6.8	0.3	1.4	0.3	2.6	0.9	-0.2	-0.6	1.7	0.2	0.3	0.5	-0.5
Average weekly champagne plus white wine intake	1.0	1.4	5.2	-1.4	-1.2	-0.1	-1.0	-0.9	-0.5	2.2	-1.0	0.0	-0.6	-0.2	-2.3
Wears glasses or contact lenses	1.0	1.1	2.3	1.4	-1.2	0.4	-0.3	-1.5	1.4	1.2	-0.7	1.1	1.5	0.4	-0.5
Ever depressed for a whole week	1.0	1.3	3.7	-0.5	-0.2	-0.5	0.3	-1.0	-1.0	-0.6	-1.8	-0.5	-1.4	-1.9	-1.8
Cholesterol lowering medication	1.0	1.5	6.4	-1.5	0.7	2.5	1.7	1.4	-1.1	0.2	0.9	-0.7	-0.1	0.9	-0.5
Crohns Disease (2017)	0.9	2.0	6.8	0.1	-2.6	0.6	-1.2	-2.1	0.1	-0.4	-2.4	0.1	-0.6	-1.9	-1.0
Crohns Disease (2012)	0.9	1.4	8.8	0.3	-3.0	0.3	-1.5	-1.6	1.0	0.1	-0.9	0.9	0.4	-0.6	0.5
Number of treatments/medications taken	0.9	1.6	5.0	-1.4	2.2	0.3	1.7	2.0	-1.3	-1.3	-0.3	-0.3	-0.1	0.5	-1.0
Stomach or abdominal pain in last month	0.9	1.1	3.6	1.9	-1.5	-1.3	-0.8	-0.3	0.5	-0.4	-0.9	1.7	0.4	-0.9	-0.2
Allergy	0.9	2.1	4.4	-1.9	-1.0	0.9	-0.5	-1.3	-2.0	-0.5	-1.3	-2.1	-2.0	-1.7	-0.7
Happiness	0.9	1.0	4.7	2.2	0.1	0.3	1.0	0.3	1.4	0.3	1.4	0.8	0.9	0.0	1.0
Pulse wave reflection index	0.9	1.1	2.5	-0.4	0.6	-0.3	1.4	0.6	-1.4	-0.7	-1.2	-0.4	-1.5	-1.6	-1.2
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.4	1.1	0.6	-0.5	-0.2	0.9	1.3	-0.3	0.9	1.2	1.4	1.0	1.5
Shortness of breath walking on level ground	0.9	1.1	5.0	1.5	0.4	-0.7	2.2	1.2	-0.4	-1.1	-0.1	-0.0	-0.5	-0.9	-1.1
Overall health rating	0.9	2.0	7.2	0.3	1.4	-0.9	1.8	1.1	-1.9	-0.7	-1.5	-0.7	-1.0	-1.3	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.3	0.4	-1.1	-1.5	-0.4	-0.9	-0.1	-0.1	-1.0	0.5	-0.5	-1.8	-1.8
Illnesses of father: None of the above (group 1)	0.9	1.1	2.7	-1.5	-1.0	-0.9	-1.7	-1.2	-0.3	1.2	0.8	-1.2	-0.2	0.9	1.1
Illnesses of father: High blood pressure	0.9	1.1	3.7	-0.3	1.9	-0.7	1.5	1.3	-1.3	0.0	-1.0	0.4	-0.8	-0.1	-1.1
Supplements: Calcium	0.9	1.0	2.6	1.4	-0.4	-0.7	-0.2	-0.7	0.7	1.6	-1.1	1.2	1.0	-0.3	-1.1
Basal cell carcinoma (self-reported)	0.9	1.1	2.9	0.8	0.1	0.8	-0.0	-0.3	1.7	0.8	1.1	1.5	1.6	1.4	0.7
Alcohol drinker status: Previous	0.9	1.0	3.3	1.7	-0.1	0.3	-0.7	0.3	1.4	0.0	1.8	0.1	0.5	0.3	1.8
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.4	1.4	0.9	-0.2	1.4	1.5	-0.1	1.0	-0.1	0.6	0.0	-0.0	-1.6
Blood Eosinophil Count	0.8	6.4	18.0	2.5	-0.3	0.8	-0.6	0.5	4.2	0.9	2.6	3.9	3.6	2.3	3.1
Pack years adult smoking proportion	0.8	1.2	4.4	-0.0	1.8	-2.1	1.3	0.4	-0.6	-1.9	0.1	-0.6	-0.1	-0.2	0.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	4.3	-0.0	-0.4	-1.3	0.1	-0.7	-0.4	1.0	-1.2	-0.4	-0.3	-1.0	-2.1
Body mass index (BMI)	0.8	3.4	6.0	-1.9	-1.9	-2.3	-1.0	-1.5	-2.3	-0.5	-1.7	-1.8	-2.4	-2.1	-1.5
Waist circumference	0.8	2.9	6.6	-1.6	-1.7	-2.6	-0.3	-1.4	-2.2	-1.1	-1.2	-1.8	-2.3	-1.9	-1.1
Hair/balding pattern: Pattern 2	0.8	1.1	3.5	0.4	1.9	0.8	1.2	1.0	-0.1	1.6	-0.7	0.0	0.6	0.4	-1.5
Forced vital capacity (FVC)	0.8	3.1	7.4	0.7	2.6	1.2	2.2	2.7	0.9	0.1	2.2	0.7	0.7	1.9	2.5
Pain all over the body in last month	0.8	0.9	3.5	-0.8	1.8	-0.3	1.0	0.5	-0.8	-1.9	-0.0	-0.4	-0.7	-0.3	0.2
Diabetes (self-reported)	0.8	1.2	4.7	0.9	1.6	0.9	2.2	1.8	0.5	1.0	1.1	0.3	0.5	0.4	-0.3
Prospective memory result	0.8	1.0	3.7	0.3	0.5	1.9	0.8	0.5	0.6	1.1	1.8	-0.4	0.5	1.0	0.8
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.7	-0.9	1.9	1.7	1.3	1.0	-0.6	-1.2	-0.4	0.1	-0.2	0.0	0.0
Angina (self-reported)	0.8	1.1	2.3	-0.3	1.4	-0.9	1.3	0.6	0.4	-1.5	-0.2	1.1	1.4	1.3	0.3
Medication: Omeprazole	0.8	0.9	6.9	0.1	-0.5	-1.2	-0.1	0.0	-0.8	1.0	-0.8	-0.6	0.3	-0.1	-2.6
Breast cancer (self-reported)	0.8	0.9	3.0	1.2	-1.7	0.5	-0.3	-1.7	-0.1	-0.3	0.2	-0.5	-1.0	-1.4	0.3
Medication: Aspirin	0.8	1.1	2.5	-1.2	1.6	-0.6	1.2	0.5	-0.5	-1.5	-0.1	0.1	0.9	1.5	-1.2
Financial situation satisfaction	0.8	1.0	5.5	0.5	0.8	0.2	2.3	2.0	-0.1	1.0	0.2	0.4	-0.1	-0.4	-0.2
Medication: Blood pressure	0.8	1.4	4.8	-1.7	-0.6	-0.8	-0.6	-0.7	-2.0	-0.3	-0.8	-2.2	-1.1	-0.4	-1.3
Bipolar Disorder (2011)	0.7	0.7	3.5	-1.9	1.5	-0.5	0.4	-0.6	0.0	-1.2	0.0	0.0	0.0	0.0	-0.5
Frequency of depressed mood in last 2 weeks	0.7	1.0	6.0	1.0	-0.9	-0.2	-0.7	-0.5	-0.6	-0.6	-0.4	-0.3	-1.5	-2.4	-0.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	3.4	1.9	0.5	-0.1	1.2	0.6	1.2	0.2	0.4	1.1	0.9	-0.2	0.1
Angina	0.7	0.9	2.6	-0.1	1.2	-0.9	1.1	0.5	0.5	-1.6	-0.2	1.1	1.4	1.1	0.2
Medication for hormone replacement therapy	0.7	0.8	3.3	0.1	-0.2	-1.8	-0.5	-0.4	0.4	1.6	-0.2	0.2	1.1	1.1	-0.1
Medication: Metformin	0.7	1.0	2.6	-0.8	0.6	-0.4	1.5	0.9	-1.2	-0.6	-0.3	-0.9	-1.6	-1.3	-0.5
Qualifications: CSEs or equivalent	0.7	0.9	5.0	-0.0	0.6	-0.5	0.4	-0.1	-1.2	-0.3	-0.8	-2.2	-1.2	-0.9	-0.4
Alcohol usually taken with meals	0.7	1.2	4.7	0.2	-0.9	-1.1	-1.8	-1.0	0.9	2.2	-0.6	0.5	0.9	0.6	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	5.8	0.7	-0.1	1.0	-0.7	-0.4	1.4	0.6	1.2	-0.6	2.0	2.4	1.5
Hair/balding pattern: Pattern 3	0.7	1.0	3.0	0.5	-0.5	1.4	-0.6	0.7	1.2	0.0	1.7	1.2	1.1	1.2	0.7
Depression (self-reported)	0.7	0.8	2.5	0.8	0.9	0.7	0.2	0.3	0.6	-1.6	1.3	0.5	0.7	0.7	1.5
Number of full brothers	0.7	0.9	2.3	-0.4	1.5	-0.3	1.2	1.1	-0.4	-1.3	-0.3	0.5	-1.0	-1.0	1.2
Worry too long after embarrassment	0.7	1.2	4.7	-0.7	-0.7	-2.2	0.1	-0.5	-1.1	-0.2	-1.1	-1.1	-1.0	-1.2	-1.6
Migraine (self-reported)	0.7	0.9	3.1	-0.2	-0.1	-0.6	-0.4	-0.3	-0.8	-0.5	-1.6	-0.3	-1.0	-1.8	-1.5
Qualifications: nursing, teaching	0.7	1.1	3.3	-1.8	-0.5	-1.5	-1.0	-0.9	-1.3	-0.9	-1.0	-0.9	-1.0	-0.1	-0.2
Miserableness	0.7	1.2	3.8	0.4	-1.1	-0.4	-0.5	-0.9	-1.3	-0.7	-0.9	-0.9	-1.5	-1.9	-1.4
Eye problems/disorders: Glaucoma	0.7	0.8	5.1	0.8	0.7	-1.0	0.6	1.0	0.6	-0.3	-0.2	2.2	0.4	-0.7	0.0
Irritability	0.7	1.1	4.2	-1.5	-0.4	-0.9	-0.5	-0.4	-1.1	-0.4	-2.1	0.0	-1.4	-1.6	-0.5
Fractured/broken bones in last 5 years	0.7	0.9	2.9	1.0	0.7	-0.2	1.1	1.4	0.7	-0.2	0.7	1.7	0.9	1.0	0.9
Pack years of smoking	0.7	1.0	5.4	0.2	1.5	-2.3	1.3	0.3	-0.4	-1.5	0.2	-0.3	0.2	-0.1	0.0
Breast Cancer	0.6	1.4	4.2	-0.1	0.5	2.1	0.3	0.6	0.9	1.8	1.9	0.5	0.6	1.3	1.3
Hearing difficulty/problems: Yes	0.6	0.9	3.8	2.0	-1.0	-0.7	-0.0	0.5	1.4	-0.2	0.7	0.9	1.4	0.1	0.3
Townsend deprivation index at recruitment	0.6	0.9	3.2	1.8	0.7	0.6	0.6	-0.1	0.2	-0.9	1.5	-0.8	-0.5	-1.1	1.0
Average weekly fortified wine intake	0.6	0.7	1.9	0.6	-0.8	-0.6	-1.4	-1.0	0.8	-1.1	-0.6	0.9	0.4	-0.6	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	5.0	2.2	-0.5	0.1	0.4	0.1	0.6	-0.3	0.4	1.2	0.1	-1.2	-0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.8	0.1	1.7	-0.9	0.3	0.7	-0.4	0.8	-0.8	1.1	-0.5	-0.7	-0.4
High blood pressure (mother)	0.6	0.8	3.0	-1.7	1.4	0.5	0.2	0.6	-1.0	-1.2	0.2	-0.8	-0.6	0.5	0.6
Hearing difficulty/problems with background noise	0.6	1.0	4.0	1.7	1.0	-0.2	2.0	1.3	0.4	-0.8	0.4	0.0	0.6	-0.5	-0.5
Had menopause	0.6	0.7	2.6	0.9	-0.2	1.2	0.3	0.3	0.9	1.0	0.5	0.2	1.6	1.2	-0.5
Weight	0.6	3.1	8.3	-2.0	-1.4	-2.9	-0.4	-1.3	-2.4	-0.4	-1.6	-1.3	-2.4	-1.7	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.6	-1.0	0.8	0.5	1.2	0.3	-1.3	-0.6	-0.8	-1.0	-0.5	0.3	-1.2
Forced vital capacity (FVC), Best measure	0.6	2.2	5.3	0.8	2.2	0.7	2.1	2.3	0.5	-0.4	1.7	0.9	0.3	1.3	2.1
Medication: Bendroflumethiazide	0.6	0.9	5.4	-0.2	1.1	0.1	2.3	1.2	-0.5	0.5	0.4	0.8	-0.0	0.5	-1.3
Average weekly beer plus cider intake	0.6	0.8	6.5	-0.5	0.2	-0.2	0.7	0.4	-1.1	-2.5	-0.2	-0.8	-0.6	-0.4	-0.3
Neuroticism (Nagel 2018)	0.5	1.1	3.1	-1.2	-0.5	-0.5	-0.2	-0.6	-1.4	-0.5	-0.5	-1.7	-1.8	-1.3	-0.9
Alzheimer’s Disease (in mother)	0.5	0.6	3.4	-0.0	1.2	-0.0	1.9	1.1	0.1	0.3	0.5	0.4	0.3	0.8	-0.6
Prostate Cancer	0.5	0.7	1.7	0.5	-0.6	0.2	-0.5	0.2	1.1	-0.3	1.0	0.9	1.1	1.0	1.3
Coronary Artery Disease (CAD)	0.5	0.6	2.9	-0.6	-0.8	-0.0	-1.7	-0.8	-0.1	0.1	0.5	0.0	0.0	0.6	1.4
Fasting Glucose	0.5	0.6	1.4	-0.3	1.1	-0.3	1.1	0.9	-0.8	-0.5	0.3	-0.5	0.0	1.2	-0.9
Allergy or Eczema	0.5	1.4	5.1	0.8	0.3	-2.2	0.0	1.2	0.8	0.5	1.0	1.9	1.1	1.5	0.4
Cardiovascular Disease	0.5	1.8	5.0	-0.1	2.1	0.7	2.2	1.4	0.2	-0.9	1.3	-0.2	1.4	2.2	-0.2
Chronotype (morning person)	0.5	1.1	4.0	0.6	-1.0	-0.0	-2.0	-0.7	-1.1	-0.1	-0.8	-1.8	-1.1	-1.1	-0.4
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-0.5	-0.8	-0.3	-0.6	-1.2	-0.9	-0.7	-0.9	-0.2	-1.1	-1.1	0.0
Systolic blood pressure, automated reading	0.5	1.4	3.5	-0.5	-1.0	-0.7	-0.6	-1.1	-1.2	-1.2	-1.1	-1.8	-1.6	-1.9	-0.5
Medication: Co-codamol	0.5	0.5	2.0	-0.6	1.4	-0.1	0.8	0.2	-0.9	0.2	-0.2	-0.1	-1.1	-0.8	-0.9
Current tobacco smoking	0.5	0.8	4.1	2.0	0.9	1.1	0.8	0.4	1.0	-0.3	0.6	0.7	0.6	-0.3	0.8
Fed-up feelings	0.5	1.0	2.4	1.4	0.7	1.3	1.6	1.2	0.4	-0.5	1.3	0.2	-0.1	-0.5	1.1
Taking other prescription medications	0.5	0.7	2.9	0.4	1.5	0.6	0.8	1.2	0.4	-1.7	0.4	0.5	0.5	0.1	0.7
Hayfever, allergic rhinitis or eczema	0.5	1.0	5.5	0.9	-0.3	-2.3	-1.0	0.2	0.9	0.7	0.2	1.6	0.7	0.7	0.3
Number of incorrect matches in round	0.5	0.8	3.3	0.4	1.1	1.8	-0.2	-0.5	0.4	-1.2	1.0	-0.1	0.9	0.8	0.6
Past tobacco smoking	0.5	0.9	2.6	0.2	0.1	-0.2	-0.7	0.7	1.1	0.7	1.2	0.1	1.3	1.5	1.6
Fluid intelligence score	0.5	1.1	3.3	-0.8	-0.8	1.4	-1.8	-0.4	1.0	1.4	-0.1	0.8	0.9	1.1	0.9
Father’s age at death	0.5	0.6	2.1	-0.0	-1.0	-0.6	-1.4	-0.5	1.2	-0.1	0.0	1.2	0.2	-0.3	0.8
Qualifications: A levels/AS levels or equivalent	0.5	1.2	4.2	-2.0	-0.2	-0.8	-1.0	0.2	-1.0	-0.9	0.3	-1.5	-1.4	0.3	1.4
Blood clot in the leg (DVT)	0.5	0.7	2.2	-0.4	1.4	1.4	0.4	0.6	-0.8	0.1	-0.1	-1.5	-0.7	-0.3	-0.6
Exposure to tobacco smoke outside home	0.5	0.7	1.8	0.2	-0.0	-1.0	0.8	0.3	-1.0	1.0	-0.0	-0.9	-1.3	-1.1	-0.9
Wheeze or whistling in the chest in last year	0.5	0.9	2.7	1.6	0.5	-1.3	1.3	0.8	1.1	0.0	0.4	0.7	0.3	-1.3	-0.4
Number of children fathered	0.5	0.6	2.3	0.5	-1.5	-0.4	-1.2	-1.0	0.2	1.2	0.2	-0.2	-0.3	-0.1	0.5
Medication: Seretide 50 evohaler	0.5	0.6	2.9	-0.6	0.7	-0.1	0.6	0.6	-0.6	-1.7	0.3	-0.9	-0.5	0.3	1.0
Had major operations	0.5	0.5	2.9	-0.7	-0.4	-0.1	-0.6	-1.7	0.8	0.1	-0.7	0.2	0.1	-0.8	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.4	1.5	1.3	0.5	0.8	0.3	0.0	-1.2	0.8	-0.5	-0.0	-0.1	-0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.3	-1.0	0.5	0.9	1.1	1.1	-0.4	0.9	-0.2	0.1	0.1	0.9	-1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.4	1.6	-0.6	0.2	-0.3	0.3	0.7	1.5	0.2	0.4	1.0	0.1	-0.8
Smoking status: Current	0.5	0.7	3.6	1.9	0.4	0.9	0.2	0.0	1.1	-0.6	0.5	0.6	0.6	-0.5	1.1
Mother’s age at death	0.5	0.6	4.7	0.9	-0.8	-2.2	0.2	-0.3	0.3	-0.0	0.0	0.7	0.2	-0.3	0.1
Alcohol drinker status: Never	0.5	0.6	1.4	-0.8	0.7	-0.4	0.7	0.6	-1.2	-0.2	-1.0	-0.7	-1.0	-0.3	-1.2
Ever smoked	0.5	0.9	3.2	0.6	0.2	-0.4	1.0	-0.5	-0.8	-0.4	-1.2	0.0	-0.9	-1.6	-1.8
Number of operations (self-reported)	0.5	0.7	2.2	-0.3	-0.3	-1.4	-0.7	-1.4	0.5	0.4	-1.5	0.9	0.2	-0.7	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.1	1.4	-0.3	0.5	-0.3	-0.2	0.8	1.0	0.4	0.1	1.2	0.3	-0.9
Age started oral contraceptive pill	0.5	0.6	1.7	-0.1	0.2	0.7	1.3	1.1	0.2	0.6	0.6	0.5	0.9	1.0	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.4	7.2	-0.2	-1.3	0.5	-2.7	-1.7	0.4	0.8	-1.1	-0.5	-0.8	-1.2	1.0
Depression (Nagel 2018)	0.4	0.6	1.7	1.0	0.6	0.5	0.7	1.0	-0.7	-0.1	0.2	-0.2	-0.8	-1.3	-0.9
Intelligence (Savage-Jansen 2018)	0.4	1.2	7.1	-0.8	-1.4	0.3	-2.7	-1.0	0.6	1.2	-1.0	-0.3	0.1	0.0	0.9
Neuroticism (2016)	0.4	0.5	3.2	0.1	0.5	1.8	1.0	-0.1	0.3	-0.4	-0.0	1.1	-0.0	-0.7	-0.3
Triglycerides	0.4	0.6	1.7	1.2	0.1	1.2	0.0	0.4	1.2	0.1	0.6	1.3	1.0	0.1	-0.2
BMI	0.4	2.4	4.8	-1.3	-2.1	-1.9	-1.1	-1.6	-1.6	-0.2	-1.4	-1.6	-2.2	-1.9	-0.5
Sensitivity / hurt feelings	0.4	0.7	1.8	0.8	-0.8	-0.0	-1.1	-0.8	1.0	1.2	0.4	1.4	0.6	-0.0	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.9	-0.6	-0.7	0.5	-1.3	-1.0	0.4	0.3	0.5	-1.6	0.8	1.7	1.2
High blood pressure	0.4	1.0	4.9	0.3	0.5	-1.5	2.2	1.2	-0.7	-0.8	0.9	0.0	0.2	0.5	-1.1
Had other major operations	0.4	0.5	1.1	-0.9	0.7	-1.0	0.3	-0.4	-0.7	-1.0	-0.6	-0.3	-0.7	-0.6	-0.4
Hip circumference	0.4	1.9	6.3	-0.7	-1.6	-2.5	-0.5	-1.4	-1.5	0.1	-1.3	-1.0	-1.6	-1.5	-1.0
Worrier / anxious feelings	0.4	0.7	2.6	-0.8	0.5	-1.6	0.3	0.2	-1.3	-0.4	-0.2	-0.5	-1.0	-0.3	-1.1
Pulse rate	0.4	0.7	2.0	0.6	0.3	1.3	0.3	0.2	1.0	1.4	1.4	0.1	0.8	0.6	0.7
Mouth/teeth dental problems: Dentures	0.4	0.7	2.5	0.2	0.8	0.6	-0.1	-0.8	-0.7	-0.3	-1.3	-0.4	-0.6	-1.6	-1.1
Gout (self-reported)	0.4	0.6	3.1	0.4	-0.0	-1.8	-0.2	-0.4	0.5	0.2	-0.3	0.8	1.3	0.8	-0.4
Arm fat-free mass (right)	0.4	1.8	6.9	-1.6	-1.3	-2.6	-1.2	-1.1	-1.6	-0.3	-0.8	-1.0	-1.8	-0.9	-0.0
Age at first live birth	0.4	0.6	2.1	0.3	-0.8	-0.4	-0.1	-0.3	-0.2	-1.0	1.4	-0.7	-0.6	0.7	1.5
Qualifications: College or University degree	0.4	1.4	3.5	-0.7	-1.6	-0.0	-1.7	-0.9	1.3	-0.4	-0.2	1.4	1.6	1.9	0.6
Eye problems/disorders: None of the above	0.4	0.4	1.3	-0.0	-1.1	0.9	-0.0	-0.9	-0.2	0.7	0.2	-1.1	-0.1	0.2	-0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	0.9	-0.4	0.3	-0.6	-1.1	0.9	0.3	-0.9	0.5	0.4	-0.6	0.9
Arm predicted mass (right)	0.4	1.9	6.3	-1.7	-1.4	-2.5	-1.3	-1.0	-1.7	-0.1	-0.9	-1.1	-1.8	-0.9	-0.1
Suffer from ‘nerves’	0.4	0.6	2.4	0.1	-0.4	-1.6	-0.3	-0.9	-0.0	-1.4	-0.4	0.1	-0.2	-1.1	-0.6
Age at last live birth	0.4	0.5	2.7	1.2	-0.1	0.5	0.5	-0.2	0.2	0.4	1.6	-0.3	-0.6	0.2	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.7	1.2	0.3	0.4	0.1	0.7	-0.5	0.4	-0.6	-0.4	-0.6	-1.3	-0.9
Mood swings	0.4	0.7	2.9	1.5	0.9	1.7	1.0	0.5	0.4	0.5	-0.4	0.3	0.3	-0.5	-0.7
Diabetes diagnosed by doctor	0.4	0.7	3.1	0.6	0.7	0.6	1.8	1.0	0.4	1.5	0.7	0.2	0.3	0.1	-0.5
Friendships satisfaction	0.4	0.5	2.0	0.5	-0.5	-0.2	-0.1	0.4	0.0	-1.0	1.1	-0.9	-0.1	0.2	1.4
Osteoporosis (self-reported)	0.4	0.5	1.9	-0.3	-0.8	-1.4	-0.0	-0.3	-0.2	0.7	-0.6	-0.4	-0.4	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	3.9	-0.8	0.1	0.4	-1.2	0.1	0.2	-1.4	0.5	-0.4	0.1	0.9	2.0
Guilty feelings	0.4	0.7	3.0	-0.1	-0.9	-1.1	-0.5	-0.6	0.0	0.5	-0.8	0.4	-0.9	-1.7	-0.7
Arm fat-free mass (left)	0.4	2.1	7.5	-1.6	-1.1	-2.7	-0.6	-0.8	-2.1	-0.5	-1.0	-1.1	-2.1	-1.2	-0.5
Myopia	0.4	0.6	2.2	-0.6	1.5	1.4	0.7	0.5	-0.0	0.8	0.4	0.7	0.5	1.0	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	2.4	-0.3	1.1	1.2	0.5	0.4	-0.7	0.4	0.1	-1.6	-0.6	-0.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.5	-0.3	-0.5	1.6	-1.3	0.0	0.6	1.4	0.1	1.1	0.5	0.6	0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.0	-0.7	0.0	-0.3	1.1	0.7	-0.8	1.4	0.1	-0.5	-1.0	-0.4	-0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.3	0.2	-0.2	0.1	0.4	-0.2	0.2	-0.7	-1.5	1.0	0.2	-0.5	-0.6
Age when periods started (menarche)	0.3	0.8	2.8	1.5	-0.3	-0.3	0.6	-0.3	1.5	-0.2	0.2	1.7	1.1	-0.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.7	1.1	-0.6	-0.7	0.4	-0.3	-0.2	-0.4	-0.8	0.3	-0.5	-1.6	-0.4
Medication: Ramipril	0.3	0.4	1.0	-0.3	-0.5	-0.8	-0.1	-0.9	-0.1	-0.9	0.4	-1.0	0.5	0.4	0.1
Impedance of arm (right)	0.3	1.5	6.2	0.6	1.8	1.6	2.5	1.4	0.8	-0.3	0.5	1.0	1.1	1.1	-0.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.3	-1.2	1.2	1.5	0.5	1.1	-0.8	0.6	0.8	-0.8	-0.7	1.0	1.3
Lung cancer (father)	0.3	0.4	1.0	0.8	-0.2	-0.4	-0.2	-1.0	-0.4	0.7	-0.5	-0.0	-0.4	-0.7	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.7	-0.4	0.9	0.9	-0.1	-0.0	-0.4	-1.6	-0.3	0.1	-0.3	0.0	0.3
Glaucoma (self-reported)	0.3	0.4	2.8	-0.0	0.6	-0.2	-0.2	0.6	0.1	-0.7	-0.1	1.7	-0.1	-0.4	0.6
Alcohol intake frequency.	0.3	0.6	1.8	0.1	1.1	-0.2	0.6	0.8	-0.9	-0.6	0.8	-1.3	-1.0	-0.4	-0.0
Comparative height size at age 10	0.3	1.7	4.3	0.2	1.8	0.1	2.1	1.5	1.0	0.3	1.4	1.3	1.3	1.5	1.5
Hypertension (Self-reported)	0.3	1.0	4.7	-0.1	0.8	-0.8	2.2	1.1	-1.0	-0.6	0.7	-0.4	0.2	0.8	-1.3
Illnesses of father: Heart disease	0.3	0.4	1.2	-0.1	0.8	1.0	0.3	0.2	0.4	-1.1	0.5	-0.5	0.4	0.6	0.9
Medication for cholesterol	0.3	0.4	1.3	0.7	-0.2	0.1	-0.2	-0.2	0.7	-0.6	-0.7	1.1	-0.4	-1.1	0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	-0.5	0.4	-1.1	-0.5	1.0	-0.5	-0.0	-0.8	-0.1	-0.3	-0.5	-0.6
Commuting to job workplace: Public transport	0.3	0.3	1.0	-0.2	0.1	0.6	-0.6	-0.7	0.4	-0.9	0.1	0.3	0.6	0.4	1.0
Medication: Lisinopril	0.3	0.3	1.0	-0.1	0.7	0.4	0.8	1.0	-0.7	-0.1	0.3	-0.5	-0.6	-0.3	-0.6
Arm predicted mass (left)	0.3	1.7	6.1	-1.4	-1.3	-2.5	-0.5	-0.8	-1.7	-0.2	-1.0	-0.8	-1.8	-1.1	-0.7
Worry (Nagel 2018)	0.2	0.4	1.4	-0.6	-0.3	-0.7	0.1	-0.1	-0.7	-1.2	0.6	-1.2	-0.8	-0.4	-0.2
Smoking Status	0.2	0.5	2.6	0.2	-0.3	0.8	0.1	-0.3	-0.2	-0.7	-0.6	-0.3	-1.1	-1.6	0.1
Neuroticism	0.2	0.6	1.5	-0.9	0.3	-0.9	0.5	0.1	-0.9	-1.0	0.3	-1.2	-1.0	-0.4	-0.1
Average weekly spirits intake	0.2	0.3	1.7	-0.5	0.2	1.3	0.6	0.3	-0.1	1.0	-0.3	-0.2	-0.1	-0.0	0.0
Impedance of leg (right)	0.2	0.8	3.1	-0.5	-1.8	-0.5	-0.7	-1.4	-0.6	-0.8	-1.2	-0.8	-0.5	-0.5	-0.5
Leg fat-free mass (left)	0.2	0.8	4.2	-1.2	-0.1	-2.0	0.3	0.1	-1.3	-0.0	-0.1	-0.5	-1.4	-0.5	-0.1
Maternal smoking around birth	0.2	0.3	1.2	0.5	-0.3	-1.1	-0.8	-0.3	0.5	0.2	-0.2	0.3	0.0	-0.6	0.2
Leg predicted mass (left)	0.2	0.9	4.3	-1.3	-0.1	-2.1	0.2	0.1	-1.3	-0.1	-0.1	-0.6	-1.5	-0.5	-0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.9	0.3	-0.1	0.2	0.3	0.3	-0.1	0.1	-0.2	-0.7	-0.8	-1.0	-0.5
Qualifications: None of the above	0.2	0.3	1.1	-0.4	-0.4	-0.6	0.3	0.0	-0.5	1.0	0.2	-0.9	-0.5	-0.5	-0.6
Neuroticism score	0.2	0.4	1.6	0.5	-0.8	-0.9	0.1	-0.6	-0.1	-0.3	-0.2	-0.0	-0.5	-1.3	-0.5
Alcohol intake versus 10 years previously	0.2	0.4	2.1	-0.1	0.5	0.6	0.4	1.0	-0.5	-1.4	0.4	-0.4	-0.0	0.0	0.4
Number of live births	0.2	0.3	1.0	0.1	-0.3	0.6	0.1	0.1	-0.3	1.0	-0.4	-0.7	-0.2	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.4	-0.6	0.7	0.8	0.6	0.9	-0.7	0.2	0.6	-0.3	-0.8	0.5	1.2
Pulse wave Arterial Stiffness index	0.2	0.3	0.8	0.9	-0.2	0.8	0.8	0.1	0.1	0.1	-0.0	-0.1	0.1	-0.5	-0.8
Impedance of arm (left)	0.2	1.0	3.5	0.7	1.2	1.1	1.9	0.9	0.9	-0.1	0.3	1.2	1.1	0.9	0.0
Breastfed as a baby	0.2	0.2	0.6	-0.6	0.1	0.7	0.4	0.1	-0.3	0.3	0.3	-0.8	-0.2	-0.1	0.5
Peak expiratory flow (PEF)	0.2	0.4	1.9	-0.8	-0.1	1.1	-0.7	0.1	-0.5	1.4	0.1	-0.6	-0.4	0.5	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.0	0.1	-1.0	-0.8	-0.6	-0.6	-0.0	0.5	-0.3	-0.0	-0.7	-0.7	1.0
Medication: Amlodipine	0.2	0.3	0.9	-0.9	0.5	-0.1	0.1	0.6	-0.9	-0.5	0.1	-0.6	-0.1	0.5	-0.4
Pulse wave peak to peak time	0.2	0.3	1.0	-1.0	0.2	-0.9	-0.7	-0.2	-0.2	-0.3	-0.0	0.1	-0.2	0.4	0.7
Pulse rate, automated reading	0.2	0.7	1.4	1.2	-0.1	-0.8	0.9	1.1	1.0	-0.2	1.2	1.2	0.2	-0.4	0.7
Family relationship satisfaction	0.2	0.2	0.8	0.7	0.1	-0.4	-0.9	0.3	0.4	-0.6	-0.4	-0.2	0.2	-0.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.6	-1.3	0.1	0.1	0.7	0.4	-1.2	0.2	-0.1	-0.3	-0.8	0.8	-0.2
Eye problems/disorders: Cataract	0.2	0.2	0.9	-0.1	0.4	-0.5	1.0	0.6	0.3	-0.2	-0.3	0.5	0.4	0.2	0.3
Whole body water mass	0.2	0.9	5.2	-1.1	-0.6	-2.3	-0.3	-0.1	-1.2	0.0	-0.2	-0.4	-1.3	-0.4	-0.1
Ever taken oral contraceptive pill	0.2	0.3	1.6	-0.5	-0.3	-0.4	-0.1	0.0	-0.0	-0.1	0.5	0.0	0.5	1.2	0.8
Basal metabolic rate	0.2	1.3	6.4	-1.5	-0.7	-2.5	-0.3	-0.3	-1.6	-0.0	-0.6	-0.6	-1.6	-0.7	-0.4
Diastolic blood pressure, automated reading	0.2	0.6	3.0	1.0	0.8	-0.2	1.7	0.5	0.1	-0.6	0.7	-0.2	-0.7	-0.9	0.0
Commuting to job workplace: Cycle	0.2	0.2	1.0	-0.1	-0.3	-0.2	0.2	-0.1	0.7	-0.8	0.1	1.0	0.2	0.2	0.7
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	-0.1	-0.1	0.6	0.3	-0.1	-0.6	0.3	-0.1	-0.5	-0.7	-0.6	-0.9
Age at First Birth	0.1	0.2	1.0	0.0	0.0	0.4	0.0	0.1	0.6	-0.5	0.0	1.0	0.2	0.3	0.5
Body Mass Index (BMI) (2010)	0.1	0.2	1.1	0.3	-0.5	1.1	0.1	-0.2	-0.1	-0.0	-0.3	-0.1	-0.4	-0.6	-0.3
Heel T-Score	0.1	0.6	1.9	0.6	-1.2	-1.4	-0.6	-0.5	0.3	0.1	0.5	-0.1	1.0	1.1	0.6
Waist Hip Ratio (WHR)	0.1	0.6	1.6	-1.1	-0.6	-0.7	0.9	-0.0	-0.5	-1.3	0.3	-0.8	-1.1	-0.7	-0.2
Hair Pigment	0.1	2.3	8.3	2.0	1.6	2.9	2.5	1.5	1.1	-0.5	0.3	1.5	0.6	-0.4	-0.5
Tanning	0.1	0.6	3.2	-0.3	-0.0	0.7	0.3	0.3	0.1	1.3	0.5	-1.1	0.9	1.8	0.2
Diabetes (mother)	0.1	0.1	0.7	0.2	-0.3	0.1	-0.0	0.6	-0.0	0.1	0.9	0.4	-0.0	0.0	-0.4
Sitting height	0.1	0.4	1.7	-0.7	1.3	-0.4	1.1	0.5	-0.1	0.0	0.2	0.5	0.1	0.9	0.5
Impedance of leg (left)	0.1	0.3	1.1	-0.3	-1.0	0.2	-0.1	-1.0	-0.2	-0.8	-0.9	-0.2	-0.0	-0.2	-0.4
Nervous feelings	0.1	0.3	0.9	0.2	0.8	0.4	0.8	0.3	0.1	-0.1	0.9	-0.6	-0.4	-0.5	0.3
Trunk fat-free mass	0.1	0.8	5.5	-1.2	-0.7	-2.4	-0.6	-0.1	-1.0	0.3	-0.2	-0.2	-1.0	-0.0	-0.1
Trunk predicted mass	0.1	0.8	5.1	-1.1	-0.6	-2.3	-0.5	-0.1	-1.1	0.2	-0.2	-0.2	-1.0	0.0	-0.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.9	0.2	0.1	-0.9	-0.0	-0.3	0.6	-0.3	0.6	0.2	0.2	0.1	0.9
Whole body fat-free mass	0.1	0.7	4.9	-1.1	-0.5	-2.2	-0.2	-0.0	-1.0	0.2	-0.1	-0.2	-1.1	-0.2	-0.0
Leg fat-free mass (right)	0.1	0.5	3.0	-0.9	0.5	-1.7	0.6	0.5	-0.9	0.1	0.2	-0.1	-1.0	-0.2	0.1
Leg predicted mass (right)	0.1	0.5	2.8	-0.9	0.4	-1.7	0.5	0.4	-0.9	0.1	0.2	-0.2	-1.0	-0.2	0.1
Height	0.0	0.5	2.7	0.1	-0.8	-1.6	0.0	-0.9	-0.2	-0.3	-0.8	0.7	-0.4	-0.3	0.2
Systolic Blood Pressure	0.0	0.2	0.5	-0.4	-0.3	0.3	-0.5	-0.4	0.0	-0.7	-0.1	0.0	-0.1	0.0	0.7
Standing height	0.0	0.4	2.6	-0.7	0.5	-1.6	0.8	0.0	-0.4	0.0	-0.1	0.8	-0.2	0.5	0.5
Impedance of whole body	0.0	0.2	0.7	0.2	-0.0	0.8	0.9	-0.3	0.3	-0.5	-0.3	0.4	0.3	0.1	0.0

Hub : Genes

FCGR2B

Models

Trait associations